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Biobased Ultralow-Density Polyurethane Foams with Enhanced Recyclability
PublicationPolyurethane (PUR) foams are widely used in many engineering applications, but their efficient recycling has remained a major challenge for many years. This study presents a novel strategy of incorporating hydrolyzable ester units into the PUR structure to enhance PUR foam recyclability. The present ecodesign concept of PUR materials enables fully the replacement of petrochemical polyols with biobased alternatives and production...
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A magnetic imprinted polymer nano-adsorbent with embedded quantum dots and mesoporous carbon for the microextraction of triazine herbicides
PublicationA magnetic molecularly imprinted polymer (MMIP) adsorbent incorporating amino-functionalized magnetite nanoparticles, nitrogen-doped graphene quantum dots and mesoporous carbon (MIP@MPC@NGQDs@ Fe3O4–NH2) was fabricated to extract triazine herbicides from fruit juice. The embedded magnetite nanoparticles simplified the isolation of the adsorbent from the sample solution. The N-GQDs and MPC enhanced adsorption by affinity binding...
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Low-volume label-free SARS-CoV-2 detection with the microcavity-based optical fiber sensor
PublicationAccurate and fast detection of viruses is crucial for controlling outbreaks of many diseases; therefore, to date, numerous sensing systems for their detection have been studied. On top of the performance of these sensing systems, the availability of biorecognition elements specific to especially the new etiological agents is an additional fundamental challenge. Therefore, besides high sensitivity and selectivity, such advantages...
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Application of 3D- printed hydrogels in wound healing and regenerative medicine
PublicationHydrogels are three-dimensional polymer networks with hydrophilic properties. The modifiable properties of hydrogels and the structure resembling living tissue allow their versatile application. Therefore, increasing attention is focused on the use of hydrogels as bioinks for three-dimensional (3D) printing in tissue engineering. Bioprinting involves the fabrication of complex structures from several types of materials, cells,...
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Engineering Candida albicans glucosamine-6-phosphate synthase for efficient enzyme purification
PublicationRationally designed muteins of Candida albicans glucosamine-6-phosphate synthase, an enzyme known as a promising target for antifungal chemotherapy, were constructed, overexpressed in Escherichia coli and purified to near homogeneity. To facilitate and to optimize the purification of the enzyme, three recombinant versionscontaining internal oligoHis fragments were constructed: (i) by substituting residues 343 - 348...
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Modelling and Analysis of the Positioning Accuracy in the Loading Systems of Mobile Cranes
PublicationIn this work, the authors analyse the influence of the order and range of sequential movements of a crane's working members on the accuracy of the final cargo positioning. The analysis was conducted on the basis of a specially developed method in which the authors proposed the introduction of a geometrical indicator of positioning the load in the intermediate positions (after completing each movement sequence) and in the target...
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Graphical interface adaption for children to explain astronomy proportions and distances
PublicationMobile Science Center is a Polish project that seeks to bring astronomy knowledge to wider social groups through various applications. In its development it is necessary to design a graphical interface that explains a concept that is difficult to assimilate such as spatial proportions and distances. This paper develops a framework to create graphical representations that explain this learning to the target audience of children....
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Towards automation of IT systems repairs
PublicationMonitoring and repair are two sides of the on-the-fly maintenance of IT systems.Monitoring is well supported by automatic tools. In contrast, repairs involve much higherhuman intervention which negatively affects reliability and efficiency. The paper intro-duces a method of automating repairs of IT systems which can be integrated with any ofthe existing monitoring mechanisms. The method is described as a collection of modelsand...
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MOOCs in SP4CE - case studies (Strategic Partnership for Creativity and Entrepreneurship)
PublicationSP4CE stands for Strategic Partnership for Creativity and Entrepreneurship project which has been funded with support from the European Commission under the ERASMUS+ Programme in the period 1st September 2014 - 31st August 2017. The main purpose of SP4CE project is to design innovative e-learning tools for collaboration between students, enterprises and teachers. It concentrates on identifying users’ needs and supports the development...
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Ultrasound assisted extraction
PublicationThe use of green and sustainable extraction techniques is very popular topic in the multidisciplinary area of chemistry, biology and technology. There is no doubt that extraction constitutes a very important step of analytical procedures of separation, detection, identification and determination of wide spectrum analytes from samples characterized by complex and very often nonhomogeneous composition of matrix. Traditional techniques...
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MobileNet family tailored for Raspberry Pi
PublicationWith the advances in systems-on-a-chip technologies, there is a growing demand to deploy intelligent vision systems on low-cost microcomputers. To address this challenge, much of the recent research has focused on reducing the model size and computational complexity of contemporary convolutional neural networks (CNNs). The state-of-the-art lightweight CNN is MobileNetV3. However, it was designed to achieve a good trade-off between...
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Validation Process for Computational Model of Full-Scale Segment for Design of Composite Footbridge
PublicationExperimental tests and numerical simulations of a full-scale segment of a foot and cycle bridge made of polymer composites are presented in the paper. The analysed structure is made of sandwich panels, which consist of glass fibre reinforced polymer (GFRP) multi-layered laminate faces and a PET foam (obtained from recycling) core. The dimensions of the segment cross-section are the same as for the target footbridge; however, span...
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MP3vec: A Reusable Machine-Constructed Feature Representation for Protein Sequences
Publication—Machine Learning (ML) methods have been used with varying degrees of success on protein prediction tasks, with two inherent limitations. First, prediction performance often depends upon the features extracted from the proteins. Second, experimental data may be insufficient to construct reliable ML models. Here we introduce MP3vec, a transferable representation for protein sequences that is designed to be used specifically for sequence-to-sequence...
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Quantum and carbon dots conjugated molecularly imprinted polymers as advanced nanomaterials for selective recognition of analytes in environmental, food and biomedical applications
PublicationSamples with complex matrix analyzed during explanation of pathogenesis of various diseases and food or environmental monitoring request advanced analytical and instrumental devices. Among the materials used for described purposes, quantum (QDs) or carbon dots (CDs) layered by molecularly imprinted polymer (MIP) shells have gained widespread attention. Unique optical and physicochemical properties of QDs/CDs together with high...
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Phytochemical screening and biological evaluation of Greek sage (Salvia fruticosa Mill.) extracts
PublicationThis study explores the influence of extraction solvents on the composition and bioactivity of Salvia fruticosa extracts. Ultrasound-assisted extraction with water, ethanol and their mixtures in variable proportions was used to produce four different extracts. An untargeted UPLC/MS‑based metabolomics was performed to discover metabolites profile variation between the extracts. In the analyzed samples, 2704 features had been detected,...
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Propagation of Ship-Generated Noise in Shallow Sea
PublicationContamination of sea environment by noise and any energy radiated to water constitutes today a problem to which more and more attention is paid, in view, a.o., of consequences of an impact of these factors onto marine fauna. European Union has introduced a directive by which EU countries are made responsible to undertake efforts aimed at reaching a good envirenmental status of European seas by 2020. A main source of underwater...
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An attempt to create a digital reconstruction of the Copper Ship = Próba cyfrowej rekonstrukcji kadłuba wraku Miedziowca
PublicationThis study presents an attempt to create a digital reconstruction of the W-5 shipwreck (the Copper Ship) based on data acquired by 3D scanning of structural components held at the National Maritime Museum in Gdańsk and on a physical reconstruction model of the ship’s hull. A digital reconstruction would facilitate analysis of various possible options for the structural design of the hull, and would enable the preparation of a model for...
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Fire-Retardant Flexible Foamed Polyurethane (PU)-Based Composites: Armed and Charmed Ground Tire Rubber (GTR) Particles
PublicationInadequate fire resistance of polymers raises questions about their advanced applications. Flexible polyurethane (PU) foams have myriad applications but inherently suffer from very high flammability. Because of the dependency of the ultimate properties (mechanical and damping performance) of PU foams on their cellular structure, reinforcement of PU with additives brings about further concerns. Though they are highly flammable and...
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Nonlinear Free and Forced Vibrations of a Hyperelastic Micro/Nanobeam Considering Strain Stiffening Effect
PublicationIn recent years, the static and dynamic response of micro/nanobeams made of hyperelasticity materials received great attention. In the majority of studies in this area, the strain-stiffing effect that plays a major role in many hyperelastic materials has not been investigated deeply. Moreover, the influence of the size effect and large rotation for such a beam that is important for the large deformation was not addressed. This...
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Determination of Peak Impact Force for Buildings Exposed to Structural Pounding during Earthquakes
PublicationStructural pounding between adjacent, insufficiently separated buildings, or bridge segments, has been repeatedly observed during seismic excitations. Such earthquake-induced collisions may cause severe structural damage or even lead to the collapse of colliding structures. The aim of the present paper was to show the results of the study focused on determination of peak impact forces during collisions between buildings exposed...
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Cross sections for electron collision with pyridine [C5H5N] molecule
PublicationThe absolute grand -total cross section (TCS) for electron scattering from pyridine, C5H5N, molecules has been measured at impact energies from 0.6 to 300 eV in the linear electron-transmission experiment. The obtained TCS energy dependence appears to be typical for targets of high electric-dipole moment; the cross section generally decreases with rising energy, except for the 3–20 eV range, where a broad enhancement peaked near...
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The Knowledge Transfer From Headquarter to Local Subsidiaries Through Expatriates - Local Employees’ Perspective
PublicationBackground. Knowledge transfer between the HQ and subsidiary has recently been targets of increasing research interest. However, the role of expatriate managers and local staff perspective on this process has not been examined enough. Research aims. This paper has two main objectives: first to develop a conceptual framework (model) of knowledge transfer between the headquarters and local subsidiary, and second to empirically evaluate...
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Glutathione-mediated conjugation of anticancer drugs: an overview of reaction mechanisms and biological significance for drug detoxification and bioactivation.
PublicationThe effectiveness of many anticancer drugs depends on the creation of specific metabolites that may alter their therapeutic or toxic properties. One significant route of biotransformation is a conjugation of electrophilic compounds with reduced glutathione, which can be non-enzymatic and/or catalyzed by glutathione-dependent enzymes. Glutathione usually combines with anticancer drugs and/or their metabolites to form more polar...
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Photosensitive and pH-dependent activity of pyrazine-functionalized carbazole derivative as promising antifungal and imaging agent
PublicationCarbazole skeleton plays a significant role as a structural scaffold of many pharmacologically active compounds. Pyrazine-functionalized carbazole derivative was constructed by coupling 2-amino-5-bromo-3-methylaminepyrazine (ABMAP) into 3 and 6 positions of the carbazole ring. Multi-experimental methods were used, e.g., potentiometric, spectroscopic (ATR, UV, XRD powder,1H and13C NMR), electrochemical (cyclic voltammetry), and...
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A Ship Domain-Based Method of Determining Action Distances for Evasive Manoeuvres in Stand-On Situations
PublicationA ship encounter can be considered safe if neither of ships’ domains (defined areas around ships) is intruded by other ships. Published research on this includes optimising collision avoidancemanoeuvres fulfilling domain-based safety conditions.However, until recently there was no method, using ship’s domain to determine exact moment when a particular collision avoidance manoeuvre can still be successfully performed. The authors...
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Analysis of multi-class pharmaceuticals in fish tissues by ultra-high-performance liquid chromatography tandem mass spectrometry
PublicationA new sensitive method based on pressurized liquid extraction (PLE) and purification by gel permeation chromatography (GPC) prior to ultra-high-performance liquid chromatography coupled to tandem mass spectrometry (UHPLC–MS/MS) was developed for the determination in fish homogenate, liver and muscle of twenty pharmaceuticals compounds and metabolites from seven commonly used therapeutic families. An extensive matrix effect evaluation...
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Glaciers as an Important Element of the World Glacier Monitoring Implemented in Svalbard
PublicationGlaciers are not only contributors to the sea level rise but also important players in the circulation of pollutants. Over a billion people apply glacial waters for domestic purposes; hence, both the quality and quantity of this water should be monitored. In this chapter, we concentrate on the archipelago Svalbard in the Arctic, a typical target area for xenobiotics from long range atmospheric transport (LRAT), holding an important share...
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Canonical switched capacitor converters. Comments, complements, and refinements
PublicationSwitched Capacitor Converters (SCC) form useful blocks in low/medium power applications as they are suitable for integration, both as off-chip and on-chip IC realizations. However, the problem with SCC is that their voltage conversion ratio is topology-dependent. By changing the SC circuit configuration, we can gain control over voltage conversion but the available ratio remains of a discrete nature, i.e. it maps into a countable...
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Objective selection of minimum acceptable mesh refinement for EMC simulations
PublicationOptimization of computational electromagnetics (CEM) simulation models can be costly in both time and computing resources. Mesh refinement is a key parameter in determining the number of unknowns to be processed. In turn, this controls the time and memory required for a simulation. Hence, it is important to use only a mesh that is good enough for the objectives of the simulation, whether for direct handling of high-fidelity EM...
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Chitosan-based electrospun nanofibers for encapsulating food bioactive ingredients: A review
PublicationToday, society has been more aware of healthy food products and related items containing bioactive compounds, which potentially contribute to human health. Unfortunately, the long-term stability and bioactivity of biologically active compounds against environmental factors compromise their target and effective action. In this way, lab-designed vehicles, such as nanoparticles and nanofibers, provide enough properties for their preservation...
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Kompleksowa analiza symulacyjna układu napędowego zespołu trakcyjnego
PublicationThe paper describes an approach to comprehensive analysis of traction electric drive. The drivetrain of ED-74 electric unit equipped with four inverter-fed induction motors was modeled in Matlab/Simulink. The model consists of functional blocks as: motors, inverters, drive controllers, filters. Structure and operation of the model was described. Chosen simulation results were presented and discussed. Two methods of modeling the...
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3D Machine Vision System for Inspection of Contact Strips in Railway Vehicle Current Collectors
PublicationConstruction and technical condition of current collectors is crucial to reliability and safety of railway transportation. According to the Technical Specifications for Interoperability railway vehicles in the European Union should be equipped with carbon contact strips. Excessive wear or defects of contact strips degrade the capability of undisturbed power transmission, cause faster wear of contact wire, and can even result in...
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Magneto-thermal convection of low concentration nanofluids
PublicationThe main aim of this paper was to analyze possible utilization of the low concentration nanofluids and the magnetic field to enhance heat transfer. The studied fluids were based on water with an addition of copper particles (40-60 nm diameter). They belonged to the diamagnetic group of materials. As a first attempt to stated target the analysis of enclosure placed in the maximal value of square magnetic induction gradient was carried...
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An NO2 sensor based on WO3 thin films for automotive applications in the microwave frequency range
PublicationA microwave system dedicated to the detection of nitrogen dioxide in the harsh environment of the Norway highways is proposed. An optimized transmission line type of sensor coated with a tungsten trioxide thin film that changes its electrical properties under NO2 gas exposure is developed. The sensors' response (S) is given in °/GHz and it is calculated based on wideband measurements. The advantage of wideband measurements in comparison...
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Technology-Driven Internationalization: Central-Eastern European Perspective
PublicationSince the 1990s of the twentieth century onward, Central-Eastern European countries have been extensively involved in these two processes—regarding increasing share of ICT and high-tech exports in country’s total export value—and additionally, across these economies, changes in the level of access to and use of ICT have been observed. The main target of this research is to contribute to the present state of the art, by proving...
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A simple modification of PCR thermal profile applied to evade persisting contamination
PublicationThe polymerase chain reaction (PCR), one of the most commonly applied methods of diagnostics and molecular biology has a frustrating downside known as the false positive signal or contamination. Several solutions to avoid and to eliminate PCR contaminations have been worked out to date but the implementation of these solutions to laboratory practice may be laborious and time consuming. A simple approach to circumvent the problem...
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The accuracy of alternative stock valuation methods – the case of the Warsaw Stock Exchange
PublicationThe main aim of this article is to examine the accuracy of different methods of share valuation used by Polish analysts in reports prepared in order to issue recommendations for companies listed on the Warsaw Stock Exchange. In the literature on the subject, the view which prevails is that the more sophisticated methods, i.e. those taking into account the discounting process, are characterised by higher valuation accuracy. However,...
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Imunofan—RDKVYR Peptide—Stimulates Skin Cell Proliferation and Promotes Tissue Repair
PublicationRegeneration and wound healing are vital to tissue homeostasis and organism survival. One of the biggest challenges of today’s science and medicine is finding methods and factors to stimulate these processes in the human body. Effective solutions to promote regenerative responses will accelerate advances in tissue engineering, regenerative medicine, transplantology, and a number of other clinical specialties. In this study, we...
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Composition and antimicrobial activity of fatty acids detected in the hygroscopic secretion collected from the secretory setae of larvae of the biting midge Forcipomyia nigra (Diptera: Ceratopogonidae)
PublicationThe hygroscopic secretion produced by the secretory setae of terrestrial larvae of the biting midge Forcipomyia nigra (Winnertz) was analysed using gas chromatography coupled with mass spectrometry (GC-MS). The viscous secretion is stored at the top of each seta and absorbs water from moist air. GC-MS analyses (four independent tests) showed that the secretion contained 12 free fatty acids, the most abundant of which were oleic...
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Implementing Sustainable Development Goals with Digital Government – Aspiration-capacity gap
PublicationSustainable Development Goals (SDGs) represent a commitment by all United Nations Member States to pursue development efforts, including ending poverty and hunger, promoting well-being and education, reducing inequalities, fostering peace, and protecting the planet. Member States and their governments are supposed to take ownership of the SDGs, strengthen the implementation means, and improve public governance as both the means...
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Efficient Simulation-Based Global Antenna Optimization Using Characteristic Point Method and Nature-Inspired Metaheuristics
PublicationAntenna structures are designed nowadays to fulfil rigorous demands, including multi-band operation, where the center frequencies need to be precisely allocated at the assumed targets while improving other features, such as impedance matching. Achieving this requires simultaneous optimization of antenna geometry parameters. When considering multimodal problems or if a reasonable initial design is not at hand, one needs to rely...
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c-Myc Protein Level Affected by Unsymmetrical Bisacridines Influences Apoptosis and Senescence Induced in HCT116 Colorectal and H460 Lung Cancer Cells
PublicationUnsymmetrical bisacridines (UAs) are highly active antitumor compounds. They contain in their structure the drugs previously synthesized in our Department: C-1311 and C-1748. UAs exhibit different properties than their monomer components. They do not intercalate to dsDNA but stabilize the G-quadruplex structures, particularly those of the MYC and KRAS genes. Since MYC and KRAS are often mutated and constitutively expressed in cancer...
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Acid–Base Equilibrium and Self-Association in Relation to High Antitumor Activity of Selected Unsymmetrical Bisacridines Established by Extensive Chemometric Analysis
PublicationUnsymmetrical bisacridines (UAs) represent a novel class of anticancer agents previously synthesized by our group. Our recent studies have demonstrated their high antitumor potential against multiple cancer cell lines and human tumor xenografts in nude mice. At the cellular level, these compounds affected 3D cancer spheroid growth and their cellular uptake was selectively modulated by quantum dots. UAs were shown to undergo metabolic...
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Testing a Variety of Features for Music Mood Recognition. Testowanie zestawu parametrów w celu rozpoznawania nastroju w muzyce
PublicationMusic collections are organized in a very different way depending on a target, number of songs or a distribution method, etc. One of the high-level feature, which can be useful and intuitive for listeners, is “mood”. Even if it seems to be the easiest way to describe music for people who are non-experts, it is very difficult to find the exact correlation between physical features and perceived impressions. The paper presents experiments...
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Alternative treatment approaches of urinary tract infections caused by uropathogenic Escherichia coli strains
PublicationUrinary tract infections (UTIs) are the most widespread and annoying infections affecting millions of people every year annually. The biggest problem of urinary diseases are recurrences, the increasing resistance of uropathogens to commonly used antibiotics, as well as the high health care costs of afflicted persons. Uropathogenic Escherichia coli strains (UPECs) are the most dominant etiologic agent of community-acquired infections...
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Do You Know What You Drink? Comparative Research on the Contents of Radioisotopes and Heavy Metals in Different Types of Tea from Various Parts of the World
PublicationThe aim of this study was to assess the potential health risks of radioactive elements and heavy metals ingested through the consumption of various types of tea imported to the Polish market (black, green, red, oolong and white). The concentrations [Bq/kg] of radionuclides (40K, 137Cs, 226Ra, 210Pb and 228Th) in tea leaves before and after brewing were measured using γ-ray spectrometry with high-purity germanium (HPGe). The concentrations...
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Effect of nitrogen doping on TiOxNy thin film formation at reactive high-power pulsed magnetron sputtering
PublicationThe paper is focused on a study of formation of TiOxNy thin films prepared by pulsed magnetron sputtering of metallic Ti target. Oxygen and nitrogen were delivered into the discharge in the form of reactive gases O2 and N2. The films were deposited by high-power impulse magnetron sputtering working with discharge repetition frequency f = 250 Hz at low (p = 0.75 Pa) and high (p = 10 Pa) pressure. The substrates were on floating...
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Inhibition of T-type calcium channel disrupts Akt signaling and promotes apoptosis in glioblastoma cells.
PublicationGlioblastoma multiforme (GBM) are brain tumors that are exceptionally resitant to both radio- and chemotherapy regimens and novel approaches to treatment are needed. T-type calcium channels are one type of low voltage-gated channel (LVCC) involved in embryonic cell proliferation and differentiation; however they are often over-expressed in tumors, including GBM. In this study, we found that inhibition of T-type Ca channels in GBM...
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Forced Degradation Studies of Ivabradine and In Silico Toxicology Predictions for Its New Designated Impurities
PublicationAll activities should aim to eliminate genotoxic impurities and/or protect the API against degradation. There is a necessity to monitor impurities from all classification groups, hence ivabradine forced degradation studies were performed. Ivabradine was proved to be quite durable active substance, but still new and with insufficient stability data. Increased temperature, acid, base, oxidation reagents and light were found to cause...
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Small regulatory bacterial RNAs regulating the envelope stress response
PublicationMost bacteria encode a large repertoire of RNA-based regulatory mechanisms. Recent discoveries have revealed that the expression of many genes is controlled by a plethora of base-pairing noncoding small regulatory RNAs (sRNAs), regulatory RNA-binding proteins and RNA-degrading enzymes. Some of these RNA-based regulated processes respond to stress conditions and are involved in the maintenance of cellular homeostasis. They achieve...