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An insight into the mixed quantum mechanical-molecular dynamics simulation of a ZnII-Curcumin complex with a chosen DNA sequence that supports experimental DNA binding investigations
PublikacjaAn important aspect of research pertaining to Curcumin (HCur) is the need to arrest its degradation in aqueous solution and in biological milieu. This may be achieved through complex formation with metal ions. For this reason, a complex of HCur was prepared with ZnII, that is not likely to be active in redox pathways, minimizing further complications. The complex is monomeric, tetrahedral, with one HCur, an acetate and a molecule...
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Measuring the density of DNA films using ultraviolet-visible interferometry
PublikacjaIn order to determine a proper value for the density of dry DNA films we have used a method based upon the measurement of interference effects in transmission spectra of thin DNA layers. Our results show that the methodology is effective and the density of DNA in this state, 1.407 g/cm3, is much lower than the commonly used 1.7 g/cm3. Obtaining accurate values for the DNA film density will allow the optical constants for DNA to...
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A vector-enzymatic DNA fragment amplification-expression technology for construction of artificial, concatemeric DNA, RNA and proteins for novel biomaterials, biomedical and industrial applications
PublikacjaA DNA fragment amplification/expression technology for the production of new generation biomaterials for scientific, industrial and biomedical applications is described. The technology enables the formation of artificial Open Reading Frames (ORFs) encoding concatemeric RNAs and proteins. It recruits the Type IIS SapI restriction endonuclease (REase) for an assembling of DNA fragments in an ordered head-to-tail-orientation. The...
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Developments in manufacturing engineering and machining process planning
PublikacjaCurrent research conducted in the Department of Manufacturing Engineering and Automation is presented in the paper. This includes: abrasive cutting off, grinding with lapping kinematics, rapid prototyping and machining procrss planning. Experimental results and computer simulation are presented and analysed.
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Swarm Algorithms in Modern Engineering Optimization Problems
PublikacjaComplexity of today engineering problems is constantly increasing. Scientists no longer are facing issues, for which simple, mathematical programming methods are sufficient. Issues like autonomic vehicle navigation or classification are considered to be challenging, and although there exist valid means to solve them, in some cases there still is some place for improvement. With emergence of a new type of optimization techniques...
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Accelerated design optimization of miniaturized microwave passives by design reusing and Kriging interpolation surrogates
PublikacjaElectromagnetic (EM) analysis has become ubiquitous in the design of microwave components and systems. One of the reasons is the increasing topological complexity of the circuits. Their reliable evaluation—at least at the design closure stage—can no longer be carried out using analytical or equivalent network representations. This is especially pertinent to miniaturized structures, where considerable EM cross-coupling effects occurring...
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Evaluation of Open Source SIEM for Situation Awareness Platform in the Smart Grid Environment
PublikacjaThe smart grid as a large-scale system of systems has an exceptionally large surface exposed to cyber-attacks, including highly evolved and sophisticated threats such as Advanced Persistent Threats (APT) or Botnets. When addressing this situation the usual cyber security technologies are prerequisite, but not sufficient. The smart grid requires developing and deploying an extensive ICT infrastructure that supports significantly...
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Nietechnologiczne nie znaczy gorsze. Rzecz o innowacjach
PublikacjaInnowacje nietechnologiczne nie zajmują istotnego miejsca w dyskursie naukowym jak i praktycznym. Zauważona luka badawcza oraz brak praktycznych rozwiązań wspierających innowacje nietechnologicznie, były motywem podjęcia tego tematu przez międzynarodowy zespół, składający się z badaczy z czterech krajów (Danii, Finlandii, Litwy i Polski) oraz szeregu instytucji wspierających biznes, w tych krajach, pełniących funkcje pośredników...
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Can the Pandemic Be a Catalyst of Spatial Changes Leading Towards the Smart City?
PublikacjaThe worldwide spread of Covid‐19 infections has had a pervasive influence on cities and the lives of their residents. The current crisis has highlighted many urban problems, including those related to the functionality of urban structures, which directly affect the quality of life. Concurrently, the notion of “smart cities” is becoming a dominant trend in the discourse on urban development. At the intersection of these two phenomena,...
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Human Resource Management Digitalisation in Multidisciplinary Ship Design Companies
PublikacjaThe digitalisation in the ship design sector is currently applied to the design process itself and is well defined, partially standardised and practically implemented by both independent design companies and the design departments of shipyards. The situation is similar in other sectors of engineering. However, the requirements for the digitalisation of other processes in design and engineering companies have not previously been...
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Distributed Architectures for Intensive Urban Computing: A Case Study on Smart Lighting for Sustainable Cities
PublikacjaNew information and communication technologies have contributed to the development of the smart city concept. On a physical level, this paradigm is characterised by deploying a substantial number of different devices that can sense their surroundings and generate a large amount of data. The most typical case is image and video acquisition sensors. Recently, these types of sensors are found in abundance in urban spaces and are responsible...
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Recent advances in rapid multiobjective optimization of expensive simulation models in microwave and antenna engineering by Pareto front exploration
PublikacjaPractical engineering design problems are inherently multiobjective, that is, require simultaneous control of several (and often conflicting) criteria. In many situations, genuine multiobjective optimization is required to acquire comprehensive information about the system of interest. The most popular solution techniques are populationbased metaheuristics, however, they are not practical for handling expensive electromagnetic...
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Problem of aggregation in dye-DNA interaction, calorimetry studies
PublikacjaNucleic acids are the biological target for many antimicrobial, antitumor and antiviral drugs. Ligand-DNA interactions can be classified into two major categories: 1. covalent binding, which can provide to intermolecular adducts, 2. physico-chemical interactions, which can be divided into intercalation (e.g. adriamycin) or groove binding (e.g. dystamycin). There are several methods to investigate interactions between drug and DNA....
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Smart heating system for home extending utilization of renewable energy sources
PublikacjaIn the paper a modern approach to smart home heating is presented. Proposed solution utilizes at least two low-polluting energy source technologies. The main idea is to connect well known ecological energy sources in a way that they can support each other and minimize risks of failure when using single system or even both of them but managed in separate way. Considered energy technologies, used separatelly, have disadvan-tages,...
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Polish experience with cold in-place recycling
PublikacjaDeep cold in-place recycling using cement and asphalt emulsion has been used for reconstruction of existing roads since the beginning of the 1990s. This paper describes the first Polish requirements for mineral-cement-emulsion mixtures. As requirements stated for the strength of the mineral-cement-emulsion mixtures were quite high, most of the mixtures were designed using high amount of cement and aggregate added for the improvement...
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Termodynamika niekowalencyjnego oddziaływania małocząsteczkowych ligandów z dna
PublikacjaKwasy nukleinowe są jednym z głównych celów biologicznych dla wielu antybiotyków oraz leków przeciwnowotworowych i przeciwwirusowych. Podczas tworzenia nowych farmaceutyków ważna jest dokładna wiedza na temat sposobu wiązania się leku do DNA. Oddziaływanie ligand-DNA można podzielić na dwie grupy: 1. wiązanie kowalencyjne, które często prowadzi do utworzenie trwałych wiązań pomiędzy nićmi DNA, 2. fizykochemiczne wiązanie, które...
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A Generative Approach to Hull Design for a Small Watercraft
PublikacjaIn the field of ocean engineering, the task of spatial hull modelling is one of the most complicated problems in ship design. This study presents a procedure applied as a generative approach to the design problems for the hull geometry of small vessels using elements of concurrent design with multi-criteria optimisation processes. Based upon widely available commercial software, an algorithm for the mathematical formulation of...
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Application of Doubly Connected Dominating Sets to Safe Rectangular Smart Grids
PublikacjaSmart grids, together with the Internet of Things, are considered to be the future of the electric energy world. This is possible through a two-way communication between nodes of the grids and computer processing. It is necessary that the communication is easy and safe, and the distance between a point of demand and supply is short, to reduce the electricity loss. All these requirements should be met at the lowest possible cost....
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Safety-based approach in multifunctional building design
PublikacjaABSTRACT: The modern trend in design of the public buildings is to create multifunctional environments in one building, hosting a variety of functions. Multifunctional buildings entertain large number of visitors. The complexity and vulnerability of this type of public space are the main reasons to use within their design process the performance based approach including the recognition of hazards. Safety and reliability approach...
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DWDM Network Laboratory Solution for Telecommunication Education Engineering
PublikacjaDevelopment of network architectures in the field of optical telecommunications technologies is an indicator of changes in telecommunication education engineering. Conducting didactic classes requires hardware infrastructure and research in terms of teaching needs. In the paper we present DWDM network laboratory solution for telecommunication education engineering on the basis of the ADVA Optical Networking equipment. We have to...
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Methods for evaluating rated power of diesel-powered generator set
PublikacjaBasic concepts for evaluating rated power of generator sets powered by combustion engines are presented in this article. A relation between parameters of the engine and the generator are shown. Recommendations contained in the standards and technical literature are systematized. The scheme and methodology for evaluating rated power of the generator set, based on laboratory research, are suggested. Also, the main problems which...
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Model szyny integracyjnej danych i ontologii procesów Smart Cities
PublikacjaW artykule przedstawiono propozycję modelu szyny integracyjnej wykorzystywanego w projektowaniu architektur systemów Smart Cities. Model takiej szyny staje się niezbędny przy projektowaniu architektur wysokopoziomowych (ang. high level architecture), w ramach których procesy silosowe organizacji powinny być widziane z pespektywy jej ontologii. Aby taka szyna mogła być wykorzystywana przez dowolne miasta zaproponowano rozwiązanie...
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Low-Molecular Pyrazine-Based DNA Binders: Physicochemical and Antimicrobial Properties
PublikacjaPyrazine and its derivatives are a large group of compounds that exhibit broad biological activity, the changes of which can be easily detected by a substituent effect or a change in the functional group. The present studies combined theoretical research with the density functional theory (DFT) approach (B3LYP/6-311+G**) and experimental (potentiometric and spectrophotometric) analysis for a thorough understanding of the structure...
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Basic sensitivity analysis of a telecommunication tower complementing standard reinforcement design process
PublikacjaThis paper presents straightforward sensitivity assessment of a telecommunication tower. The analysis is set toidentify the elements of the tower which may be reinforced with the greatest structural advantage. As current expertopin ions on structural redesign of similar structures due to a planned addition of extra loads are mainly based ondeterministic computations or engineering intuition,...
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The Rule-Based Model of Negentropy for Increasing the Energy Efficiency of the City’s Digital Transformation Processes into a Smart City
PublikacjaThe aim of the article is to build a rule-based model (RMFDN) for increasing the energy efficiency of Smart Cities’ digital transformation processes. The problem that arises during the implementation of digital transformation processes concerns the measures that should be assigned to estimate the duration of the digital transformation. Previous studies of digital transformation have been based on the analysis of design processes...
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Paradoxes in the engineering change management process
PublikacjaPurpose: The main purpose of this paper is to conceptualize and operationalize paradoxes that are significant in the engineering change management (ECM) process. The following research question was stated: What are the paradoxes that influence the ECM process, and how can they be measured? Design/methodology/approach: The study is divided into two parts: conceptualization and operationalization. Conceptualization involved a literature...
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Metylacja DNA w rozwoju, diagnostyce i terapii nowotworów
PublikacjaDotychczas kowalencyjna modyfikacja DNA, jaką jest zarówno naturalna metylacja DNA, jak i addukty DNA egzogennych niskocząsteczkowych związków chemicznych, były ropatrywane z punktu widzenia genomu. W świetle obecnej wiedzy dotyczącej epigenomu można sądzić, że stosunkowo niewielkie modyfikacje czy to w postaci metylacji cytozyny, czy adduktu DNA mogą mieć znaczący wpływ na działanie komórki, a co za tym idzie także jej transformację...
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Metoda projektowania systemów Smart Cities bazowana na Case Based Reasoning
PublikacjaCelem artykułu jest prezentacja wyników badań nad opracowaniem metody projektowania systemów Smart Cities. Metoda ta bazuje na analizie przypadków projektowania systemów Smart Cities w miastach, wybór odpowiedniego do wymagań zdecydowanego na wdrożenie ośrodka i jego zastosowanie. Do budowy proponowanej metody projektowania wykorzystano metodę Case Based Reasoning oraz mechanizmy konwersji procesów i ról projektowych do procesów...
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Do online reviews reveal mobile application usability and user experience? The case of WhatsApp
PublikacjaThe variety of hardware devices and the diversity of their users imposes new requirements and expectations on designers and developers of mobile applications (apps). While the Internet has enabled new forms of communication platform, online stores provide the ability to review apps. These informal online app reviews have become a viral form of electronic wordof-mouth (eWOM), covering a plethora of issues. In our study, we set ourselves...
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Design aspects of a low-cost prosthetic arm for people with severe movement disabilities
PublikacjaIn this paper the main aspects of mechanical design behind the low-cost prosthetic arm are presented. The fundamentals of a proper design has been defined to obtain functional 3D printed 5 degree of freedom (DOF) prosthesis. The designed prosthetic arm is a part of the hybrid interface with eye tracking movement control. The main focus was to create affordable but usable prosthesis which corresponds in size and weights to the human...
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Smart grid technologies in electric traction: Mini inverter station
PublikacjaThe growing number of trams and trolleybuses equipped with recuperation systems contribute to the increase in the amount of energy recovered during braking. It raises questions about the possibility of its usage. One of such possibilities is the use of smart grid technology. The paper presents a case study of the use of braking energy in the trolleybus system for external loads by implementing mini inverter stations. Analysis is...
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Design and investigations of the ethanol microturbine
PublikacjaThe paper presents the results of the design analysis and experimental investigations of the microturbine set consisting of the microturbine with partial admission and permanent magnet generator. The microturbine was designed for operation with the vapour of ethanol as a working fluid. Microturbine unit was tested for different parameters of the working fluid and varying the electrical load. The examples and the comparison between...
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Mathematical models of process quality on the example of the bakery industry
PublikacjaThis article presents a new approach to quantitative dimensionless assessment of the efficiency and competitiveness of production processes. New concepts of process quality and relative product quality have been introduced. Process quality was expressed in vector and scalar. The process quality vector ono was expressed by the product of reliability by the vector from the sum of three components taking into account the composition...
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Rough Set-Based Classification of EEG Signals Related to Real and Imagery Motion
PublikacjaA rough set-based approach to classification of EEG signals registered while subjects were performing real and imagery motions is presented in the paper. The appropriate subset of EEG channels is selected, the recordings are segmented, and features are extracted, based on time-frequency decomposition of the signal. Rough set classifier is trained in several scenarios, comparing accuracy of classification for real and imagery motion....
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COLLABORATIVE LEARNING ENVIRONMENT FOR ENGINEERING EDUCATION (COLED)
PublikacjaCollaborative Learning Environment for Engineering Education is a European project implemented under the Erasmus + program, The main goal of 5 partners from 4 different European countries – Bulgaria, Poland, Portugal and Romania is to develop an innovative collaborative training approach, encompassing curricula related to the introduction of enterprise automation. Project activities are carried out in the period from Dctober 2018...
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Hip endhoprothesis development using rapid prototyping methods
PublikacjaIntegrated product development based on Rapid Prototyping methods, connected with computer aided 3D design and computer aided engineering enables fast and full new product verification and validation. A case study derived from clinical and technological practice using hip implant construction is also included.
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Therapeutic intervention by the simultaneous inhibition of DNA repair and type I or type II DNA topoisomerases: one strategy, many outcomes
PublikacjaMany anticancer drugs reduce the integrity of DNA, forming strand breaks. This can cause mutations and cancer or cell death if the lesions are not repaired. Interestingly, DNA repair-deficient cancer cells (e.g., those with BRCA1/2 mutations) have been shown to exhibit increased sensitivity to chemotherapy. Based on this observation, a new therapeutic approach termed 'synthetic lethality' has been developed, in which radiation...
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Informacyjna warstwa przestrzeni komercyjnej - smart city a wizerunek miasta
PublikacjaW artykule przedstawiono wielopoziomowy wpływ technologii informacyjnych na przestrzeń miasta. Na wstępie zaprezentowano krótką charakterystykę smart city, która została rozpatrzona w kontekście przestrzeni komercyjnych. W dalszej części rozważono kwestię "ukrytej" inteligencji wspomagającej w mieście różnorodne procesy. Omówiono także zasięg emisji informacji w przestrzeni komercyjnej. Najważniejsze miejsce w artykule zajmuje...
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Importance of model tests in design and operation of watercraft for example CTO
PublikacjaShip Hydromechanics Division is a specialized research and development department of Ship Design and Research Centre conducting tests and research in the field of hydromechanics, connected with design and operation of ships and other floating structures, in scope of: predictions, numerical analyses, designs of - hull shape optimized with respect to the ship’s functions with the application of modern design tools, screw propellers...
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Numerical solutions for large deformation problems in geotechnical engineering
PublikacjaThe problem of large deformations often occurs in geotechnical engineering. Numerical modeling of such issues is usually complex and tricky. The chosen solution has to implicate soil-soil and soil-structure interactions. In this paper, a review of the most popular numerical methods for large deformation problems is presented. The Coupled Eulerian-Lagrangian (CEL) method, the Arbitrary Lagrangian-Eulerian (ALE) method, the Smoothed...
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Review of intelligent software architectures for the development of an intelligent decision support system for design process planning in concurrent engineering
PublikacjaW artykule poddano dogłębnej analizie szereg inteligentnych technik miękkie-go modelowania pod katem ich przydatności w obszarze wspomagania procesówplanowania dla inżynierii współzadaniowej. Skoncentrowano się na wspomaganiujednego z najważniejszych obszarów inżynierii współzadaniowej, a mianowicieprocesu projektowania. W wyniku analizy zaproponowano architekturę wspomaga-nia opartą na tablicowej bazie wiedzy modelującej wnioskowanie...
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Increased concentration of Taq DNA polymerase as a solution for GC-rich templates from clinical and environmental samples
PublikacjaDNA polymerase is an enzyme which plays crucial role in replication and DNA repair. It found application in PCR (polymerase chain reaction) where catalyses process of in vitro DNA synthesis. To meet the demands posed by mod- ern diagnostic, molecular biology or genetic engineering it is necessary to improve DNA polymerases to obtain new or better features useful in these fields. So far implemented modifications in majority are...
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IMPROVING THE QUALITY OF EDUCATION THROUGH THE IMPLEMENTATION OF THE DIPLOMAS AND GROUP PROJECTS DURING ENGINEERING STUDIES IN COOPERATION WITH EMPLOYERS
PublikacjaThe quality of education is one of the most important factors determining the job opportunity for graduates. The authors present the possibility of carrying out the diplomas in cooperation with employers and institutions interested in employment of students who graduated Gdansk University of Technology, Faculty of Civil and Environmental Engineering and University of Warmia and Mazury, Faculty of Geodesy and Land Management (major:...
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IMPROVING THE QUALITY OF EDUCATION THROUGH THE IMPLEMENTATION OF THE DIPLOMAS AND GROUP PROJECTS DURING ENGINEERING STUDIES IN COOPERATION WITH EMPLOYERS
PublikacjaThe quality of education is one of most important factors determining the job opportunity for graduates. The authors present the possibility of carrying out the diplomas in cooperation with employers and institutions interested in employment of students who graduated Gdansk University of Technology, Faculty of Civil and Environmental Engineering and University of Warmia and Mazury, Faculty of Geodesy and Land Management (major:...
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Problems and Solutions of Software Design in Scrum Projects
PublikacjaThe aim of the paper is to identify the problems and solutions of the software design in Scrum project as well as to analyze the effectiveness of the solutions. Through a series of workshops with 4 experts from IT industry and academia we have identified 52 problems and 99 unique solutions. In this paper we present a list of 10 common problems and 5 solutions for each problem selected by the number of sources. The effectiveness...
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On the Importance of Resilience Engineering for Networked Systems in a Changing World
PublikacjaResilience is featured increasingly often in the media, usually applied to society when faced, for example, with disasters such as flooding and the enormous challenges that the Covid-19 pandemic posed. There are now many resilience-related discussion groups worldwide, and some standards initiatives devoted in particular to city resilience. However, there is relatively little explicit interest in resilience engineering for communication...
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Environmental Degradation of Engineering Materials & Materials Engineering and Technologies
Publikacja -
Termodynamiczne aspekty oddziaływania niskocząsteczkowych ligandów z DNA
PublikacjaKwasy nukleinowe są celem biologicznym dla wielu antybiotyków oraz leków przeciwnowotworowych i przeciwwirusowych. Dlatego podczas tworzenia nowych farmaceutyków ważna jest dokładna wiedza na temat sposobu wiązania się leku do DNA.Oddziaływanie ligand-DNA można podzielić na dwie grupy: 1. wiązanie kowalencyjne, które często prowadzi do utworzenie trwałych wiązań pomiędzy nićmi DNA, 2. fizykochemiczne wiązanie, które może być podzielone...
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Smart Weighing Scale with Feet-Sampled ECG
PublikacjaIn a smart home, health and well-being monitoring systems could be embedded in everyday devices providing a pervasive care. A home bathroom scale is an example of such a device, typically used to measure body weight and very often its composition (e.g. body water/fat percentage). In this paper, we analyzed a potential use of the bathroom scale to measure electrocardiogram (ECG) from electrodes located on the scale's tile. In particular...
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Single-phase power electronics transformer with active functions for smart grid
PublikacjaThis paper presents the control of one cell of a modular single-phase power electronics transformer with active functions for meeting the smart grid concept. In this way, the converter could be used not only as a conventional transformer but also for grid such as reactive power, harmonic elimination and energy storage. The topology of the cell is composed by a bidirectional converter with three stages: a half bridge in the input...