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Wyniki wyszukiwania dla: RAPID PROTOTYPING PROPELLER
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A review on computer‐aided chemogenomics and drug repositioning for rational COVID ‐19 drug discovery
PublikacjaApplication of materials capable of energy harvesting to increase the efficiency and environmental adaptability is sometimes reflected in the ability of discovery of some traces in an environment―either experimentally or computationally―to enlarge practical application window. The emergence of computational methods, particularly computer-aided drug discovery (CADD), provides ample opportunities for the rapid discovery and development...
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One More Step Towards a Circular Economy for Thermal Insulation Materials—Development of Composites Highly Filled with Waste Polyurethane (PU) Foam for Potential Use in the Building Industry
PublikacjaThe rapid development of the building sector has created increased demand for novel materials and technologies, while on the other hand resulting in the generation of a severe amount of waste materials. Among these are polyurethane (PU) foams, which are commonly applied as thermal insulation materials. Their management is a serious industrial problem, due to, for example, their complex chemical composition. Although some chemical...
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Sklepy typu pop-up – od Guerilla Stores marki Comme de Garcons przez unikalne doświadczenie zakupowe Bikini Berlin do ... ?
PublikacjaObiekty, sklepy typu pop- up pojawiały się w miastach ponad dziesięć lat temu. Otwierane są na krótki okres czasu w celu promocji marki i nawiązania bezp o- średniego kontaktu z odbiorcą. Pop -up’y różnią się od tradycyjnych, stacjona r- nych sklepów rodzajem prowadzonej w nich działalności, mającym na celu przede wszystkim promocję marki. Pierwsze tymczasowe obiekty, tzw. Guerilla stores , stworzone zostały w 2004 roku...
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Low-cost multi-objective optimization and experimental validation of UWB MIMO antenna
PublikacjaPurpose–The purpose of this paper is to validate methodologies for expedited multi-objective designoptimization of complex antenna structures both numerically and experimentally.Design/methodology/approach–The task of identifying the best possible trade-offs between theantenna size and its electrical performance is formulated as multi-objective optimization problem.Algorithmic frameworks are described for finding Pareto-optimal...
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Studies of the Modelling Accuracy of Steam Turbine Control Systems for Diagnostic Tests of Automatic Synchronizers
PublikacjaOne of the important factors that affect the reliable operation of the power system and the rapid restitution after disaster is a quick and effective combining synchronous electric power facilities to operate in parallel. Hence, diagnostics of automatic synchronizers at every stage of their life, from building a prototype, through the whole life, until removing such devices from the operation, is an extremely important and responsible...
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Stormwater runoff in the urbanized coastal basin of Gdańsk Urbanized basin of Gdańsk
PublikacjaAnthropopressure strongly affects the primal water cycle. Alternation of the natural basins imposes changes of drainage patterns, reduction of bioretention, infiltration and base flow. As a result the overland flow predominates and greater runoff rates flow into storm water collection systems and reservoirs. Moreover changing climatic conditions increase the frequency of rapid extreme weather events. Infrastructures of urban areas...
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Comparison of hydrophilic interaction and reversed phase liquid chromatography coupled with tandem mass spectrometry for the determination of eight artificial sweeteners and common steviol glycosides in popular beverages
PublikacjaHydrophilic interaction liquid chromatography (HILIC) coupled with tandem mass spectrometry (MS/MS) was used to separate artificial and natural sweeteners approved for use in European Union (EU). Among three tested HILIC columns (BlueOrchid PAL-HILIC, Ascentis Express Si and Acclaim™ Trinity™ P2) the last one was selected for the development of HILIC method due to the best results obtained with it. Early eluting and coeluting compounds...
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The New LM-PCR/Shifter Method for the Genotyping of Microorganism
PublikacjaTechniques relies on the ligation of appropriates adapters (LM-PCR) as AFLP, PCR MP and ADSRRS are successfully used for epidemiological studies for prokaryotic and eukaryotic microorganisms. In this study we propose a new method, called the LM-PCR/Shifter, based on the use of a Class IIS restriction enzyme giving restriction fragments with different 4 base 5' overhangs (Shifter) and the ligation of appropriate oligonucleotide...
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The dispersive micro-solid phase extraction method for MS-based lipidomics of human breast milk*
PublikacjaA simple and rapid microextraction method ensuring high lipidome coverage was developed for liquid chromatography mass spectrometry (LC-MS)-based lipidomics of human breast milk. The dispersive microsolid phase extraction (D-µ-SPE) technique, coupled with the design of experiment (DoE) method, enabled the study of the influence of several conditions (desorption solvent, stationary phase ratio, and sorption and desorption time)...
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Commercial function as a treat to the monument - 25 years of experience in the commercialization of monuments in Gdansk, Poland
PublikacjaThe principles of the market economy adopted in Poland in the nineties have significantly touched the resources of immovable monuments. As a result, monuments have become a product of culture subject to the rules of the free market; and state ownership, patronage and decision-making practice has now been replaced by private interest. Practical monument use has also changed with the shift in ownership of objects after privatization...
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Introducing concurrent engineering to space and satellite technology undergraduate course
PublikacjaIn recent decade concurrent engineering has become a de facto leading methodology of work in space, aeronautics and sometimes even automotive industry. It has been used in designing ESA space missions for 20 years now, with rst Concurrent Design Facility (CDF) built in ESTEC in 1998. Still, it has not become a universal standard in engineering, and universities are specically reluctant to adopt it into their curricula. As a result,...
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Detection of Bioactive Compounds in Organically and Conventionally Grown Asparagus Spears
PublikacjaIn the recent reports, there are contradictory conclusions about the nutritional and health properties of organic and conventionally growing vegetables. We hypothesized that organic cultivation system results in higher quality of asparagus (Asparagus officinalis L.) because of organic manure and effective organisms. Therefore, new analytical methods were applied in order to find the differences in bioactive compounds between the...
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Fast, sensitive and reliable multi-residue method for routine determination of 34 pesticides from various chemical groups in water samples by using dispersive liquid – liquid microextraction coupled with gas chromatography – mass spectrometry
PublikacjaA simple and efficient dispersive liquid-liquid microextraction technique (DLLME) was developed by using a mixture of two solvents: 40 μL of tetrachlorethylene (extraction solvent) and 1.0 mL of methanol (disperser solvent), which was rapidly injected with a syringe into 10mL ofwater sample. Some important parameters affecting the extraction efficiency, such as type and volume of solvents, water sample volume, extraction time,...
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5G/6G optical fronthaul modeling: cost and energy consumption assessment
PublikacjaIn fifth generation (5G) and the future beyond 5G (6G) radio access networks (RANs), the cost of fronthaul deployment is a main challenge for mobile network operators. Depending on different constraints, there are various solutions to deploy an efficient fronthaul. Fiber-optic-based fronthaul offers long-term support with regard to a rapid increase in capacity demands. When fiber connections, either point-to-point (P2P) or point-to-multipoint...
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Enhancing the bioconversion rate and end products of black soldier fly (BSF) treatment – A comprehensive review
PublikacjaFood security remains a pressing concern in the face of an increasing world population and environmental challenges. As climate change, biodiversity loss, and water scarcity continue to impact agricultural productivity, traditional livestock farming faces limitations in meeting the growing global demand for meat and dairy products. In this context, black soldier fly larvae (BSFL) have emerged as a promising alternative for sustainable...
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Conditions for increasing the recognition of degradation in thermal-flow diagnostics, taking into account environmental legal aspects
PublikacjaThe ever-increasing demand for electricity and the need for conventional sources to cooperate with renewable ones generates the need to increase the efficiency and safety of the generation sources. Therefore, it is necessary to find a way to operate existing facilities more efficiently with full detection of emerging faults. These are the requirements of Polish, European and International law, which demands that energy facilities...
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Development and Validation of SPE-HPLC-MS/MS Method for Determining Cyclophosphamide in Surface Waters
PublikacjaA rapid and selective method for trace amounts determination of cyclophosphamide in surface water samples has been developed. A solid phase extraction SPE method for extraction and clean-up procedure has been optimized for determination by reversed-phase high-performance liquid chromatography with tandem mass spectrometry. The analyses proceed in the positive ion mode by means of the electrospray ionization method (ESI). Clean...
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An evaluation of sucrose as a possible contaminant in e-liquids for electronic cigarettes by hydrophilic interaction liquid chromatography–tandem mass spectrometry
PublikacjaThe influence of sucrose combustion products on smoking and nicotine addiction is still controversial because the presence of the sucrose may be treated as a source of aldehydes and organic acids. In e-liquids used as refills for electronic cigarettes, which are made primarily of poly(propylene glycol), glycerine and ethanol, sucrose may be present at trace levels, and its impact on mainstream smoke formation, and hence on human...
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Visible light photoactivity of TiO2loaded with monometallic(Au or Pt) and bimetallic (Au/Pt) nanoparticles
PublikacjaTiO2modified with monometallic (Au or Pt) and bimetallic (Au/Pt) nanoparticles have been preparedusing a water-in-oil microemulsion system (water/AOT/cyclohexane) followed by calcination step. Theeffect of metal ratio, reducing agent type (NaBH4or N2H4), TiO2matrix type (P-25, ST-01, TiO-5, TiO2nano-tubes or TiO2obtained by TIP hydrolysis) as well as calcination temperature (from 350 to 650◦C) weresystematically investigated. Obtained...
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Fast GC as a useful tool for authenticity assessment of kiwifruit
PublikacjaKiwifruit is one of the healthiest fruits due to its high content of biologically active substances and nutrients. The most popular species of Actinidia (kiwifruit) are the Actinidia deliciosa fruits called kiwi and Actinidia chinensis commonly called golden kiwi, while the lesser known species is Actinidia arguta known as mini kiwi. Bioactivities and nutrients of Actinidia are influenced by species and cultivars. It is very important...
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Synthesis, Chemical Characterization and Multiscale Biological Evaluation of a dimericcRGD Peptide for Targeted Imaging of αVβ3 Integrin Activity
PublikacjaCyclic peptides containing the Arg-Gly-Asp (RGD) sequence have been shown to specifically bind the angiogenesis biomarker α V β3 integrin. We report the synthesis, chemical characterization, and biological evaluation of two novel dimeric cyclic RGD-based molecular probes for the targeted imaging of α V β3 activity (a radiolabeled version, 64Cu-NOTA-PEG4-cRGD2, for PET imaging, and a fluorescent version, FITC-PEG4-cRGD2, for in...
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Real-time monitoring of volatiles and particles emitted from thermoplastic filaments during 3D printing
PublikacjaThe proliferation of consumer-grade three-dimensional (3D) printers using fused deposition, also known as fused filament fabrication, has given rise to concerns over the exposure of users to potentially harmful substances. Thermoplastic filaments made of different polymers are extruded through a heated printer nozzle and deposited layer by layer on a build platform to form the printed object. This process leads to the emission...
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Non-Satellite Broadband Maritime Communications for e-Navigation Services
PublikacjaThe development of broadband network access technologies available to users on land has triggered a rapid expansion of a diverse range of services provided by terrestrial networks. However, due to limitations of digital communication technologies in the off-shore area, the maritime ICT systems evolution so far has not followed that trend. Despite the e-navigation initiative defining the set of Maritime Services, the progress in...
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Constrained multi-objective optimization of compact microwave circuits by design triangulation and pareto front interpolation
PublikacjaDevelopment of microwave components is an inherently multi-objective task. This is especially pertinent to the design closure stage, i.e., final adjustment of geometry and/or material parameters carried out to improve the electrical performance of the system. The design goals are often conflicting so that the improvement of one normally leads to a degradation of others. Compact microwave passives constitute a representative case:...
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Sources and composition of chemical pollution in Maritime Antarctica (King George Island), part 1: Sediment and water analysis for PAH sources evaluation in the vicinity of Arctowski station
PublikacjaThe paper presents a study regarding the identification of polycyclic aromatic hydrocarbons (PAHs) in fresh waters and surface sediments on the western shore of Admiralty Bay over four sampling seasons from 2017 to 2018. The results were compared to literature data from 2016 to provide a more comprehensive image of the environmental fate of PAHs over the years. The highest value of Σ PAHs was 82.9 ng/L and 445 ng/g dw in water...
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Modelling AOB-NOB competition in shortcut nitrification compared with conventional nitrification-denitrification process
PublikacjaIn particular, mainstream deammonification and/or shortened nitrificationdenitrification via nitrite (so-called “nitrite shunt”) is a promising new treatment concept that has the potential to revolutionise how nitrogen removal is achieved at WWTPs. Understanding the role of the AOB/NOB competition in the nitrogen cycle in wastewater treatment systems will change operational strategies of the novel nitrogen removal processes. The...
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CaO-based high temperature CO2 sorbents – Literature review
PublikacjaThe use of CaO-based adsorbents has a high potential to capture CO2 from various systems due to its high reactivity with CO2, high capacity, and low cost of naturally derived CaO. The application of CaO-based sorbents to remove carbon dioxide is based on a reversible reaction between CaO and CO2. However, multiple carbonation/calcination cycles lead to a rapid reduction in the sorption capacity of natural CaO, and therefore efforts...
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Emerging oxidized and defective phases in low-dimensional CrCl3
PublikacjaTwo-dimensional (2D) magnets such as chromium trihalides CrX3 (X ¼ I, Br, Cl) represent a frontier for spintronics applications and, in particular, CrCl3 has attracted research interest due its relative stability under ambient conditions without rapid degradation, as opposed to CrI3. Herein, mechanically exfoliated CrCl3 flakes are characterized at the atomic scale and the electronic structures of pristine, oxidized, and defective...
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Informal Settlements and International Migrants: The city of Rome (Italy) as Case Study
PublikacjaToday, urbanization is happening at an unprecedentedly rapid rate, owing heavily to the influx of migrants. Empirical evidence shows the development of informal settlements in cities as a result of migration, including Rome. Furthermore, information on informal settlements is either insufficient or inadequate, which makes it challenging for architects, urban planners, and policymakers to form viable solutions to deal with the situations...
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COVID-19 and digital deprivation in Poland
PublikacjaResearch background: The problem of digital deprivation is already known, but the COVID-19 pandemic has highlighted its negative consequences. A global change in the way of life, work and socialisation resulting from the epidemic has indicated that a basic level of digital integration is becoming necessary. During the lockdown, people were forced to use ICTs to adapt to a rapidly changing reality. Current experience with coronavirus...
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Conjugates of Ciprofloxacin and Levofloxacin with Cell-Penetrating Peptide Exhibit Antifungal Activity and Mammalian Cytotoxicity
PublikacjaSeven conjugates composed of well-known fluoroquinolone antibacterial agents, ciprofloxacin (CIP) or levofloxacin (LVX), and a cell-penetrating peptide transportan 10 (TP10-NH2) were synthesised. The drugs were covalently bound to the peptide via an amide bond, methylenecarbonyl moiety, or a disulfide bridge. Conjugation of fluoroquinolones to TP10-NH2 resulted in congeners demonstrating antifungal in vitro activity against human...
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Effect of Arc Strikes on High Strength Low Alloy Steels Welded by SMAW
PublikacjaWet welding with covered electrodes (Shielded Metal Arc Welding – SMAW) is the most commonly used method of carrying out welding repair works in a water environment. Limited visibility and the inability to move freely under water result in an increased risk of formation of welding imperfections such as lack of fusion, lack of penetration and arc strikes. The work focused on changes in the properties and structure of steel subjected...
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Computationally-Efficient Statistical Design and Yield Optimization of Resonator-Based Notch Filters Using Feature-Based Surrogates
PublikacjaModern microwave devices are designed to fulfill stringent requirements pertaining to electrical performance, which requires, among others, a meticulous tuning of their geometry parameters. When moving up in frequency, physical dimensions of passive microwave circuits become smaller, making the system performance increasingly susceptible to manufacturing tolerances. In particular, inherent inaccuracy of fabrication processes affect...
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Management of ground tire rubber waste by incorporation into polyurethane-based composite foams
PublikacjaRapid economic growth implicated the developing multiple industry sectors, including the automotive branch, increasing waste generation since recycling and utilization methods have not been established simultaneously. A very severe threat is the generation of enormous amounts of post-consumer tires considered burdensome waste, e.g., due to the substantial emissions of volatile organic compounds (VOCs). Therefore, it is essential...
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Komputerowo wspomagana analiza elastycznych siłowników elektrostatycznych dla potrzeb implementacji w systemach mechatroniki
PublikacjaPrzeprowadzone badania naukowe rozpoczęto od szczegółowej analizy układu mechatronicznego dłoni robotycznych, powstałych na przestrzeni ostatnich 40 lat, w celu dokładnego rozpoznania ich głównych wymogów konstrukcyjnych i ograniczeń systemowych. Z uwagi na brak dostępnych narzędzi do symulacji omawianych siłowników, w rozprawie opracowano uniwersalne narzędzie – program do analizy numerycznej. U jego podstawy założono wykorzystanie...
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Phytoecdysteroid containing plants – a source of bioactive compounds with potential anticarcinogenic effects
PublikacjaEcdysteroids are a group of steroids synthesized in inver- tebrates as molting hormones and also in some plants as secondary metabolites acting as a defense against parasites. These compounds do not naturally occur in mammals and are not structurally related to mammalian steroid hor- mones, consequently do not activate mammalian hormone receptors. Ecdysteroids exhibit very low toxicity to mam- mals and to date no serious side effects...
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Application of analytical methods for the determination of bioactive compounds in some berries
PublikacjaFluorometry, ESI-MS, FTIR, and radical scavenging assays were used for characterization of bioactive compounds and the levels of their antioxidant activities. Polyphenols, flavonoids, anthocyanins, and ascorbic acid and the level of antioxidant activity of water extracts of “Murtilla-like” [Myrteola nummularia (Poiret) Berg.], and other widely consumed berries were determined and compared. The contents of bioactive compounds and...
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The chemistry of river–lake systems in the context of permafrost occurrence (Mongolia, Valley of the Lakes) Part II. Spatial trends and possible sources of organic composition
PublikacjaThe chemistry of river–lake systems located in Central Mongolia near the southern border of permafrost occurrence has not been well studied. The main aim of this paper is to summarize patterns in water chemistry in supply springs, rivers and lakes in relation to permafrost occurrence, as well as other natural and anthropogenic impacts. The analyses involved water samples taken from two river–lake systems: the Baydrag River–Böön...
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Influence of laser melting on surface layer properties of titanium alloy Ti6Al4V
PublikacjaIn time of rapid technology and medicine progress, implants are becoming more widely used in the human body, ranging from dental implants, stabilizing plates, screws, orthopaedic prostheses. For example, there are many types of hip prostheses used for hip replacement as well as various types of materials used for these orthopaedic prostheses. Properties of titanium alloys used in hip prostheses combined with good strength properties,...
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Development and validation of a GC–MS/MS method for the determination of 11 amphetamines and 34 synthetic cathinones in whole blood
PublikacjaPurpose Psychoactive compounds that contain a phenylethylamine structure (such as amphetamine-type stimulants and synthetic cathinones) are one of the major classes of stimulants on the recreational drug market. Approximately 670 new psychoactive substances (NPS) are monitored only in Europe; however, new psychoactive compounds are being developed for illicit trade each year. In this context, the development of new analytical procedures...
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Determination of free tyrosine in equestrian supplements by LC–MS/MS and comparison of its quantity with total free amino acids content in view of doping control
PublikacjaThe reports on the probable beneficial impact of tyrosine (TYR) supplementation on performance enhancement have contributed to the growth of interest in TYR in equestrian sports field and related industries, such as the manufacture of dietary and nutritional supplements. In this study, the first attempt to the assessment of horses exposure to TYR during nutritional supplementation was demonstrated by quantification of unbound TYR...
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Environmental characteristics of a tundra river system in Svalbard. Part 1: Bacterial abundance, community structure and nutrient levels
PublikacjaThe Arctic hosts a set of unique ecosystems, characterised by extreme environmental conditions and undergoing a rapid change resulting from the average temperature rising. We present a study on an aquatic ecosystem of the Revelva catchment (Spitsbergen), based on samples collected from the lake, river and their tributaries, in the summer of 2016. The landscape variety of the study site and the seasonal change in the hydrological...
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Emerging anticancer activity of candidal glucoseamine-6-phosphate synthase inhibitors upon nanoparticle-mediated delivery
PublikacjaNumerous glutamine analogues have been reported as irreversible inhibitors of the glucosamine-6-phosphate (GlcN-6-P) synthase in pathogenic Candida albicans in the last 3.5 decades. Among the reported inhibitors, the most effective N3-(4-methoxyfumaroyl)-L-2,3- diaminopropanoic acid (FMDP) has been extensively studied in order to develop its more active analogues. Several peptide−FMDP conjugates were tested to deliver FMDP to its...
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Electrochemical simulation of metabolism for antitumor-active imidazoacridinone C-1311 and in silico prediction of drug metabolic reactions
PublikacjaThe metabolism of antitumor-active 5-diethylaminoethylamino-8-hydroxyimidazoacridinone (C-1311) has been investigated widely over the last decade but some aspects of molecular mechanisms of its metabolic transformation are still not explained. In the current work, we have reported a direct and rapid analytical tool for better prediction of C-1311 metabolism which is based on electrochemistry (EC) coupled on-line with electrospray...
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Edible dragonflies and damselflies (order Odonata) as human food – A comprehensive review
PublikacjaThe rapid growth of the human population leads to a big concern about the food y and demand worldwide. However, due to the reduction in global arable land area, humans need to find alternative food sources to fulfil their needs. Consequently, edible insects have been identified as a promising solution to ameliorate food security and increase global nutrition. Among more than 2,100 identified edible insect species, dragonflies and...
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Algorithmic Human Resources Management
PublikacjaThe rapid evolution of Digital Human Resources Management has introduced a transformative era where algorithms play a pivotal role in reshaping the landscape of workforce management. This transformation is encapsulated in the concepts of algorithmic management and algorithmic Human Resource Management (HRM). The integration of advanced analytics, predictive and prescriptive analytics and the power of Artificial Intelligence (AI)...
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c-Myc inhibition and p21 modulation contribute to unsymmetrical bisacridines-induced apoptosis and senescence in pancreatic cancer cells
PublikacjaBackground Pancreatic cancer (PC) is one of the most aggressive cancers and is the seventh leading cause of cancer-related death worldwide. PC is characterized by rapid progression and resistance to conventional treatments. Mutations in KRAS, CDKN2A, TP53, SMAD4/DPC4, and MYC are major genetic alterations associated with poor treatment outcomes in patients with PC. Therefore, optimizing PC therapy is a tremendous challenge. Unsymmetrical...
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The impact of filler thermomechanical modifications on static and dynamic mechanical performance of flexible foamed polyurethane/ground tire rubber/zinc borate composites
PublikacjaThe rapid development of the automotive industry is very beneficial to many aspects of human life, but it is also a very significant environmental burden. The most straightforward impact is related to the generation of exhaust, but the management of post-consumer car parts is also a major challenge. Among them, waste tires are very burdensome due to their enormous numbers. Therefore, it is essential to develop novel, environmentally...
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Occurrence and seasonal variations of 25 pharmaceutical residues in wastewater and drinking water treatment plants
PublikacjaThousands of tons of pharmaceuticals are introduced into the aqueous environment due to their incomplete elimination during treatment process in wastewater treatment plants (WWTPs) and water treat- ment plants (WTPs). The presence of pharmacologically active compounds in the environment is of a great interest because of their potential to cause negative effects. Furthermore, drugs can undergo different pro- cesses leading to the...
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MEASUREMENT AND ANALYSIS OF A FLOOD WAVE PROPAGATION ON THE KACZA RIVER IN GDYNIA IN NORTHERN POLAND
PublikacjaKacza river is located in northern Poland in the neighborhood of the Gulf of Gdansk and the Baltic Sea. A Kacza having length of 15 km and catchment area of 53 km2 collects the water into the Gulf mostly from inhabited and forested areas within the administrative boundaries of the city of Gdynia. On the 14th and 15th of July 2016 in northern Poland on the large area of Tri-City agglomeration (Gdynia, Gdansk and Sopot) total daily...