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Development and evaluation of RADA-PDGF2 self-assembling peptide hydrogel for enhanced skin wound healing
PublikacjaBackground: Wound healing complications affect numerous patients each year, creating significant economic and medical challenges. Currently, available methods are not fully effective in the treatment of chronic or complicated wounds; thus, new methods are constantly sought. Our previous studies showed that a peptide designated as PDGF2 derived from PDGF-BB could be a promising drug candidate for wound treatment and that RADA16-I...
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Transiluminacyjne monitorowanie stanu przestrzeni podpajęczynówkowej
PublikacjaTransiluminacja tkanek ludzkiego ciała w celach diagnostycznych jest stosowana od ponad stu lat. Metoda transiluminacji w bliskiej podczerwieni z rozpraszaniem zwrotnym (NIRT-BSS) umożliwia ciągłe, bezinwazyjne monitorowanie zmian szerokości przestrzeni podpajęczynówkowej, które może być cennym narzędziem w ocenie zagrożenia obrzękiem mózgu. W rozprawie przedstawiono optyczny model rozchodzenia się promieniowania podczerwonego...
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MaliciousIDE – software development environment that evokes emotions
PublikacjaEmotions affect every aspect of human live, including work. Numerous studies in software engineering have shown that negative emotions can lower the productivity of programmers. Unlike traditional approaches to managing software development, modern methods, such as Agile and Lean, take into account human aspects of programming. To thoroughly investigate the impact of negative emotions on the work of programmers, a malicious integrated...
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Testing the Diagnostic Utility of Recombinant Toxoplasma Gondii Chimeric Antigens – Generated Datasets
PublikacjaThe datasets titled Toxoplasma gondii recombinant chimeric antigens – IgM and IgG ELISAs – mouse serum samples and Toxoplasma gondii recombinant chimeric antigens – IgG and IgM ELISAs – human serum samples contain absorbance measurements obtained during serological tests using mouse and human sera in enzyme-linked immunosorbent assay (ELISA) tests based on recombinant chimeric antigens. The datasets allows a comparison of absorbance...
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Analysis of MArkers of Exposure to Constituents of Environmental Tobacco Smoke (ETS)
PublikacjaTobacco smoke is a complex mixture of more than 4000 chemical compounds, many of which are harmful to human health. These compounds belong to various chemical classes, including amides, imides, lactams, carboxylic acids, aldehydes, ketones, alcohols, phenols, amines, hydrocarbons, ethers, and inorganic compounds. There are three types of tobacco smoke streams: the mainstream, the sidestream, and environmental tobacco smoke (ETS)....
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Development of a Control System for an Autonomous Seaplane
PublikacjaSelf-driving vehicles, also branded as driverless vehicles, autonomous vehicles, or robotic vehicles, are transport systems that can operate with a reduced human impact or even with any human input at all. The content of the present paper is limited to three types of potential applications: Unmanned Surface Vehicles (USVs), Autonomous Underwater Vehicles (AUVs) and Unmanned Aerial Vehicles (UAV). We set our particular focus on...
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Ocena wpływu dodatku oliwy z oliwek na degradację termiczną rafinowanego oleju rzepakowego
PublikacjaTłuszcze jadalne to ważny składnik diety człowieka. Mają one znaczący wpływ na prawidłowe funkcjonowanie ludzkiego organizmu. Podczas smażenia olej podlega przemianom chemicznym, dlatego spożywane tłuszcze powinny charakteryzować się jak największą stabilności oksydacyjnej. Celem prowadzonych badań było określenie jakości olejów rzepakowego, mieszanego oraz rafinowanej oliwy z oliwek, pochodzących z rynku krajowego. Podczas badań...
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Big Data in Regenerative Urban Design
PublikacjaWhy the use of Big Data in regenerative planning matters? The aim of this chapter is to study under what conditions Big Data can be integrated into regenerative design and sustainable planning? Authors seek to answer how – when related to the ecosystem and to human activities – Big Data can be used to: • both shape policies that support the development of regenerative human settlements, • support restorative design for practitioners...
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Organizational culture as prerequisite of proactive safety and security management in critical infrastructure systems including hazardous plants and ports
PublikacjaThis article addresses selected aspects of organizational culture to be considered in the context of knowledge based proactive safety and security management of plants, ports and systems of critical infrastructure. It has been often emphasized in the domain literature that business effectiveness of such plants and their resilience against hazards and threats to avoid major accidents depends substantially on human and organizational...
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Tacit knowledge influence on intellectual capital and innovativeness in the healthcare sector: A cross-country study of Poland and the US
PublikacjaThis study provides empirical proof that whole organizational innovativeness is rooted in tacit knowledge due to its potency of human capital creation and, that a learning culture composed of a learning climate and mistakes acceptance component fosters human capital development. The main practical implication is that if the IC components are externally rather than internally determined in the particular organization embedded in...
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Analysis of volatile fraction of hybrid fruit pulp using Proton Transfer Reaction - Time-Of-Flight Mass Spectrometry
PublikacjaFruits and vegetables are important ingredients in human diet. Because of this, it is very important to know their exact composition and to control their quality. Based on the aroma of food products, it is possible to pre-evaluate their quality and freshness. The aim of this work was to characterize the volatile fraction of the hybrid fruit ‘sweetie’ using the modern analytical device PTR-TOFMS. Hybrid fruit samples are human-made...
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Menstrual synchrony: Fact or artifact?
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Ecosensitivity and genetic polymorphism of somatic traits in the perinatal development of twins
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Multiuser Stereoscopic Projection Techniques for CAVE-Type Virtual Reality Systems
PublikacjaDespite the development of increasingly popular head mounted displays, CAVE-type systems may still be considered one of the most immersive virtual reality systems with many advantages. However, a serious limitation of most CAVE-type systems is the generation of a three-dimensional (3-D) image from the perspective of only one person. This problem is significant because in some applications, the participants must cooperate with each...
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Inhibitory and antimicrobial activities of OGTI and HV-BBI peptides, fragments and analogs derived from amphibian skin
PublikacjaA series of linear and cyclic fragments and analogs of two peptides (OGTI and HV-BBI) isolated from skin secretions of frogs were synthesized by the solid-phase method. Their inhibitory activity against several serine proteinases: bovine beta-trypsin, bovine alpha-chymotypsin, human leukocyte elastase and cathepsin G from human neutrophils, was investigated together with evaluation of their antimicrobial activities against Gram-negative...
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Degradable poly(ester-ether) urethanes of improved surface calcium deposition developed as novel biomaterials
PublikacjaBones, which are considered as hard tissues, work as scaffold for human body. They provide physical support for muscles and protect intestinal organs. Percentage of hard tissues in human body depends on age, weight, and gender. Human skeleton consists of 206 connected bones. Therefore, it is natural that the hard-tissue damage such as fractures, osteoporosis, and congenital lack of bone may appear. The innovative way of bone healing...
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Pumping effect measured by PIV method in multi-layer spike electrode EHD device for air cleaning
PublikacjaDust particles can be harmful for human health when inhaled. Especially dangerous are submicron dust particles, which can contain traces of toxic elements and can easily penetrate into human respiratory system. Thus, new devices for air cleaning are needed. In this work the flow velocity field patterns measured by Particle Image Velocimetry (PIV) method in an electrohydrodynamic (EHD) device for air cleaning are presented. The...
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Drinking water safety evaluation in the selected sub-Saharan African countries: A case study of Madagascar, Uganda and Rwanda
PublikacjaIn the sub-Saharan region of Africa, access to safe drinking water remains limited in many countries. This study provides an overview of the quality of surface water and groundwater in rural and peri-urban areas of Madagascar, Uganda, and Rwanda. Selected physico-chemical parameters, inorganic species (including inorganic ions), and organic pollution indicators, such as total organic carbon, non-ionic surfactants, cationic surfactants, anionic...
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The degradation of metal implants
PublikacjaThe presence of metal implants in the human body causes some dangers, which result from introducing another object into organism. There may occur a biocorrosion, which causes different modifications of implant surface.
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SERVICE ORIENTED SCENARIOS FOR SUPPORT ENTERPRISE PROJECT MANAGEMENT
PublikacjaIn the paper, a service oriented architecture is used to describe various scenarios of human-oriented enterprises. They can be modeled by BPMN to show basic information flow. We consider business scenarios to present another modeling solution called service orchestration or service mashup. That approach gives an opportunity for the right management through taking the best possible choice of services, or composition of services....
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Insights into oral microbiome and colorectal cancer – on the way of searching new perspectives
PublikacjaMicrobiome is a keystone polymicrobial community that coexist with human body in a beneficial relationship. These microorganisms enable the human body to maintain homeostasis and take part in mechanisms of defense against infection and in the absorption of nutrients. Even though microbiome is involved in physiologic processes that are beneficial to host health, it may also cause serious detrimental issues. Additionally, it has been...
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From tryptophan to novel mitochondria-disruptive agent, synthesis and biological evaluation of 1,2,3,6-tetrasubstituted carbazoles
PublikacjaMitochondrial targeting plays an important role in anticancer therapy. The Mn(III)-promoted cyclization of 5- (1H-indol-3-yl)-3-oxopentanoic acid allow to obtain novel substituted carbazole derivatives that can act as mitochondria-disruptive agents. The starting materials used for the synthesis of these new aminocarbazoles are oxopentanoate derivatives of tryptophan. The scope and limitation of this method of synthesis are determined...
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Quinoline-based thiazolyl-hydrazones target cancer cells through autophagy inhibition
PublikacjaHeterocyclic pharmacophores such as thiazole and quinoline rings have a significant role in medicinal chemistry. They are considered privileged structures since they constitute several Food and Drug Administration (FDA)-approved drugs for cancer treatment. Herein, we report the synthesis, in silico evaluation of the ADMET profiles, and in vitro investigation of the anticancer activity of a series of novel thiazolyl-hydrazones based...
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Antifungal dipeptides incorporating an inhibitor of homoserine dehydrogenase
PublikacjaThe antifungal activity of 5‐hydroxy‐4‐oxo‐L‐norvaline (HONV), exhibited under conditions mimicking human serum, may be improved upon incorporation of this amino acid into a dipeptide structure. Several HONV‐containing dipeptides inhibited growth of human pathogenic yeasts of the Candida genus in the RPMI‐1640 medium, with minimal inhibitory concentration values in the 32 to 64 μg mL−1 range. This activity was not affected by multidrug...
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The impact of the temperament model on the behavior of an autonomous driver
PublikacjaBecause it is generally believed that the personality and temperament of a human driver influence his/her behavior on the road, the article presents a computational model of the temperament of an autonomous agent - a driver. First, a short review of the four ideas of Galen’s temperament in psychology is presented. Temperament traits are grouped into four other sets, one of which is chosen for implementation in the project of integration...
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Novel Tools for Comprehensive Functional Analysis of LDLR (Low-Density Lipoprotein Receptor) Variants
PublikacjaFamilial hypercholesterolemia (FH) is an autosomal-dominant disorder caused mainly by substitutions in the low-density lipoprotein receptor (LDLR) gene, leading to an increased risk of premature cardiovascular diseases. Tremendous advances in sequencing techniques have resulted in the discovery of more than 3000 variants of the LDLR gene, but not all of them are clinically relevant. Therefore, functional studies of selected variants...
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Etyka - o konieczności dyskursu etycznego w organizacjach
PublikacjaDo budowania zasad dobrego funkcjonowania organizacji, do odkrywania mechanizmów jej funkcjonowania, analizowania ludzkich potrzeb i możliwości ich realizowania, do wpływu warunków ekonomicznych i kulturowych na sposób funkcjonowania organizacji – do tych problemów przywiązuje się wielką wagę w naukach o zarządzaniu. Czy równie dużą wagę przykłada się – i docenia – rangę zachowań ludzkich w sferze moralnej, wpływ zasad etycznych...
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Zarządzanie wiedzą w małych przedsiębiorstwach oferujących wiedzochłonne usługi biznesowe
PublikacjaCelem artykułu jest przedstawienie praktyk zarządzania wiedzą oraz czynników wpływających na sukces, bądź porażkę w ich wdrażaniu na podstawie badania jakościowego przeprowadzonego w trzech firmach działających na terenie województwa pomorskiego. Firmy te należą do sektora małych i średnich przedsiębiorstw oraz oferują wiedzochłonne usługi biznesowe (knowledge-intensive business services – KIBS). W artykule podjęto próbę odpowiedzi...
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Wyzwania współpracy z robotem jako członkiem zespołu
Publikacja– Cel: Ocena, jakie są przekonania dotyczące współpracy z robotami w zespole, jakie są obawy i oczekiwania związane z „zatrudnianiem” robotów. – Metodyka badań: Badania ilościowe zrealizowane z zastosowaniem kwestionariusza ankiety w grupie 593 specjalistów IT. – Wyniki badań: Roboty nadal traktowane są głównie jako narzędzia, nie jako podmioty uczestniczące w pracy zespołu. Przekonanie, że obecność robota w zespole nie wyeliminuje...
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The Effect of Conjugation with Octaarginine, a Cell-Penetrating Peptide on Antifungal Activity of Imidazoacridinone Derivative
PublikacjaAcridine cell-penetrating peptide conjugates are an extremely important family of compounds in antitumor chemotherapy. These conjugates are not so widely analysed in antimicrobial therapy, although bioactive peptides could be used as nanocarriers to smuggle antimicrobial compounds. An octaarginine conjugate of an imidazoacridinone derivative (Compound 1-R8) synthetized by us exhibited high antifungal activity against reference...
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The Action Mechanisms, Anti-Cancer and Antibiotic-Modulation Potential of Vaccinium myrtillus L. Extract
PublikacjaHerbal medicinal products containing Vaccinium myrtillus L. (bilberry) fruits and fruit extracts are widely available in the market. Although bilberry leaves and stems are considered as bio-waste, they contain much higher levels of phenolic compounds than fruits. The study aimed to investigate the antimicrobial and anticancer potential of aerial part extracts from Vaccinium myrtillus L. (V. myrtillus, VM) plants harvested at high...
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Use of optical skin phantoms for preclinical evaluation of laser efficiency for skin lesion therapy
PublikacjaSkin lesions are commonly treated using laser heating. However, the introduction of new devices into clinical practice requires evaluation of their performance. This study presents the application of optical phantoms for assessment of a newly developed 975-nm pulsed diode laser system for dermatological purposes. Such phantoms closely mimic the absorption and scattering of real human skin (although not precisely in relation to...
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Tacit Knowledge Sharing and Value Creation in the Network Economy: Socially Driven Evolution of Business
PublikacjaKey factors which affect competitive advantage in the network economy are innovation, relationships, cooperation, and knowledge. Sharing knowledge is not easy. Companies find it problematic. Presented studies show that the essence of the value creation today is not in sharing explicit but rather tacit knowledge, which is a source of creativity and innovation. Delivering value through knowledge does not only require efficient Transactive...
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Application of Electronic Nose to Ambient Air Quality Evaluation With Respect to Odour Nuisance in Vicinity of Municipal Landfills and Sewage Treatment
PublikacjaThis chapter contains information about application of the electronic nose type instruments to evaluation of ambient air odour quality connected with such sectors of human activity as municipal landfills or sewage treatment plants. The authors present potential sources of emission from these sectors, characterize the chemical compounds responsible for presence of unpleasant odours, describe the influence of those compounds on human...
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Pumping effect measured by PIV method in a multilayer spike electrode EHD device for air cleaning
PublikacjaDust particles can be harmful for human health when inhaled. Particularly dangerous are submicrometer dust particles, which can contain traces of toxic elements and can easily penetrate into the human respiratory system. Thus, efficient devices for the air cleaning from submicrometer dust particles are needed. Recently, Katatani and Mizuno have proposed an electrohydrody- namic (EHD) device for air cleaning for submicrometer particles....
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BIOMATERIALS AND IMPLANTS IN CARDIAC AND VASCULAR SURGERY - REVIEW
PublikacjaCurrently, on prosthesis in cardiac blood vessels and heart valves are used materials of animal or synthetic origin. For animal materials include, among others pericardial sac in which is the heart. Materials such as this (natural) are characterized by a remarkable biocompatibility within the human body, but their main disadvantage is the relatively low durability. In turn, synthetic materials, which include the austenitic chromium-nickel-molybdenum...
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Autonomous Driver Based on an Intelligent System of Decision-Making
PublikacjaThe paper presents and discusses a system (xDriver) which uses an Intelligent System of Decision-making (ISD) for the task of car driving. The principal subject is the implementation, simulation and testing of the ISD system described earlier in our publications for the task of autonomous driving. The design of the whole ISD system is a result of a thorough modelling of human psychology based on an extensive literature study. Concepts...
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Emotion Recognition Using Physiological Signals
PublikacjaIn this paper the problem of emotion recognition using physiological signals is presented. Firstly the problems with acquisition of physiological signals related to specific human emotions are described. It is not a trivial problem to elicit real emotions and to choose stimuli that always, and for all people, elicit the same emotion. Also different kinds of physiological signals for emotion recognition are considered. A set of...
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Breastfeeding as a regulating factor of the development of the intestinal microbiome in the early stages of life
PublikacjaSince the first bacterial inhabitants of the human gastrointestinal tract were identified, a lot of research into the study of the human microbiome and its effects on health has been conducted. Currently, it is accepted that humans have a symbiotic relationship with the gut microbiome, though the specifics of this relationship are not well understood. The microbiome of neonates constantly changes and appears to influence many facets...
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Exploring Stock Traders’ Cognitive Biases: Research Design and Simulator Framework
PublikacjaCognitive bias is a phenomenon that has been extensively studied in stock trading and many other fields. This paper presents a framework for a Mobile Stock Trading Simulator (MSTS) that facilitates automatic investment in stocks with minimal human influence, by investigating the behavioral patterns and cognitive errors of stock market investors. The paper aims to determine whether investors’ investment strategies can be improved...
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Information retrieval with semantic memory model
PublikacjaPsycholinguistic theories of semantic memory form the basis of understanding of natural language concepts. These theories are used here as an inspiration for implementing a computational model of semantic memory in the form of semantic network. Combining this network with a vector-based object-relation-feature value representation of concepts that includes also weights for confidence and support, allows for recognition of concepts...
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Embodying Intelligence in Autonomous and Robotic Systems with the Use of Cognitive Psychology and Motivation Theories
PublikacjaThe article discusses, on a certain level of abstraction and generalization, a coherent anthropological approach to the issue of controlling autonomous robots or agents. A contemporary idea can be based on appropriate modeling of the human mind using the available psychological knowledge. One of the main reasons for developing such projects is the lack of available and effective top-down approaches resulting from the known research...
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Multi-layered tissue head phantoms for noninvasive optical diagnostics
PublikacjaExtensive research in the area of optical sensing for medical diagnostics requires development of tissue phantoms with optical properties similar to those of living human tissues. Development and improvement of in vivo optical measurement systems requires the use of stable tissue phantoms with known characteristics, which are mainly used for calibration of such systems and testing their performance over time. Optical and mechanical...
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Embodying Intelligence in Autonomous Systems with the Use of Cognitive Psychology and Motivation Theories
PublikacjaThe article discusses, on a certain level of abstraction and generalization, a coherent anthropological approach to the issue of controlling autonomous robots or agents. A contemporary idea can be based on appropriate modeling of the human mind using the available psychological knowledge. One of the main reasons for developing such projects is the lack of available and effective top-down approaches resulting from the known research...
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A framework for Air Quality Management Zones - Useful GIS-based tool for urban planning: Case studies in Antwerp and Gdańsk
PublikacjaThere is a growing recognition of the importance of proper urban design in the improvement of air flow and pollution dispersion and in reducing human exposure to air pollution. However, a limited number of studies have been published so far focusing on the development of standard procedures which could be applied by urban planners to effectively evaluate urban conditions with respect to air quality. To fill this gap, a new approach...
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Compressive and tensile properties of polyurethane foam mimicking trabecular tissue in artificial femoral head bones
PublikacjaThe presented study aimed to examine the compressive and tensile behavior of the polyurethane foams mimicking trabecular tissue in the artificial human femurs and assess their potential to replicate osteoporotic type of human bone tissue. Two types of Synbone femur models: one of the normal density (model 2350) and one of the lower density (model LD2350), and three types of Sawbones femur models (model 1130-21-8, 1130-21-3, 1130-192)...
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Żywność funkcjonalna- najważniejsze osiągnięcia w zakresie badań i wykorzystania
PublikacjaW wielu ośrodkach naukowych trwają badania ukierunkowane na poznanie mechanizmów działania składników żywności funkcjonalnej na poziomie ekspresji genetycznej, co stwarza możliwość precyzyjniejszego scharakteryzowania funkcji bioaktywnych składników diety z uwzględnieniem zmienności genetycznej populacji. Daje to w efekcie bardziej wiarygodne wyniki badań naukowych dotyczących wpływu bioaktywnych składników diety na funkcjonowanie...
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Człowiek zanurzony w rzeczywistości wirtualnej na przykładzie Laboratorium Zanurzonej Wizualizacji Przestrzennej
PublikacjaArtykuł opisuje Laboratorium Zanurzonej Wizualizacji Przestrzennej (LZWP), które umożliwia swobodną podróż w czasie i przestrzeni. Jego podstawowym wyposażeniem jest jaskinia rzeczywistości wirtualnej, czyli pomieszczenie o ścianach, suficie i podłodze stanowiących ekrany projekcyjne, wyświetlające generowane komputerowo obrazy 3D, tworzące spójny widok jednej sceny. Człowiek znajdujący się w takiej jaskini jest zatem zanurzony...
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Wikipedia Articles Representation with Matrix'u
PublikacjaIn the article we evaluate different text representation methods used for a task of Wikipedia articles categorization. We present the Matrix’u application used for creating computational datasets ofWikipedia articles. The representations have been evaluated with SVM classifiers used for reconstruction human made categories.
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Analytical aspects of model compounds toxicity assessment using MTT and Microtox bioanalytica assays
PublikacjaMore and more increased intensity of anthropopressure processes can be observed, among other things, in the release of great quantities of synthetic substances into the environment, including the Endocrine Disrupting Compounds. The effects of the above-mentioned human impact on the environment not only can be noticed in the homeostasis disturbance in ecosystems, but they are also visible with respect to human. The high incidence...