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Wyniki wyszukiwania dla: SPEKTROMETRIA MAS (MS)
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An LC-MS/MS Method for a Comprehensive Determination of Metabolites of BTEX Anaerobic Degradation in Bacterial Cultures and Groundwater
PublikacjaBTEX (benzene, toluene, ethylbenzene, and the different xylene isomers), known for carcinogenic and neurotoxic effects, are common environmental contaminants. The first step for the development of the bioremediation technologies is the detection of intense microbial degradation in contaminated waters in the quest for the most active bacterial strains. This requires the multispecies analysis for BTEX metabolites which are considered...
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Analysis of bisphenols and their derivatives in infant and toddler ready-to-feed milk and powdered milk by LC MS/MS
PublikacjaReady-to-feed milk and powdered milk packed in different types of packaging lined with resin are chosen as the primary or complementary diet for infants and toddlers. An HPLC–MS/MS method was established and validated for the determination of nineteen bisphenols and their derivatives in such samples. The recoveries were from 31% to 120%, while the values of limit of detection and quantification were in the range of 0.24–0.40 and...
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Technika spektrometrii mas rozcieńczania izotopowego jako narzędzie dla poprawy jakości wyników analitycznych
PublikacjaTechnika spektrometrii mas rozcieńczania izotopowego (IDMS) jako pierwotna technika pomiarowa jest bezpośrednio związana z układem SI i odgrywa niezwykle istotną rolę w zapewnieniu spójności pomiarowej - jest zalecana przede wszystkim w przeprowadzaniu badań certyfikacyjnych. Z tego względu znajduje się coraz powszechniejsze zastosowanie w analityce chemicznej a w szczególności w zakresie analityki środowiskowej. W pracy przedstawiono...
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Determination of benzodiazepines and Z-hypnotic drugs in whole blood samples by GC–MS/MS: Method development, validation and application
PublikacjaBenzodiazepines (BZDs) and Z-drugs are widely used as anxiolytics, sedative hypnotics, anticonvulsants and muscle relaxants. “Designer benzodiazepines” (DBZDs) are a new psychoactive substance class consisting of benzodiazepine derivatives that are not allowed for medical use and are known for being used recreationally. From a toxicologist standpoint, the huge number of such substances implicate a necessity for developing fast...
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Identification of novel psychoactive substances 25B-NBOMe and 4-CMC in biological material using HPLC-Q-TOF-MS and their quantification in blood using UPLC–MS/MS in case of severe intoxications
PublikacjaThis paper describes cases of poisoning caused by new psychoactive substances such as: 25BNBOMe (2-(4-bromo-2,5-dimethoxyphenyl)-N-[(2-methoxyphenyl)methyl]ethanamine) and 4-CMC (1-(4-chlorophenyl)-2-(methylamino)-1-propanone). The analytical procedure includes rapid and selective method for the extraction and determination of 4-CMC and 25B-NBOMe in blood samples using UPLC–MS/MS technique. To the best of our knowledge,this is...
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Determination of impurities in pharmaceutical products using LC-MS
PublikacjaPharmaceutical products can be contaminated by residues of solvents, reagents (used for the synthesis) or degradation products. Impurities in drug may pose a risk to human health and life, therefore analysis and identification of impurities in pharmaceutical products is veryimportant and inevitable.High performance liquid chromatography coupled with mass spectrometry (MS) is very useful technique for identification impurities in...
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Hypoglycaemic, antioxidative and phytochemical evaluation of Cornus mas varieties
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Relationship of colour with the phytocompounds present in Cornus mas cultivars
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Comparison of GC–MS and MEKC methods for caffeine determination in preworkout supplements
PublikacjaIn this study, GC–MS- and MEKC-based methods for determination of caffeine (CAF) in preworkout supplements were developed and validated. The proposed protocols utilized minimal sample preparation (simple dilution and syringe filtration). The developed methods achieved satisfactory validation parameters, i.e. good linearity (R2 0.9988 and R2 0.9985 for GC–MS- and MEKC-based method, respectively), satisfactory intraand interaccuracy...
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Determination of free tyrosine in equestrian supplements by LC–MS/MS and comparison of its quantity with total free amino acids content in view of doping control
PublikacjaThe reports on the probable beneficial impact of tyrosine (TYR) supplementation on performance enhancement have contributed to the growth of interest in TYR in equestrian sports field and related industries, such as the manufacture of dietary and nutritional supplements. In this study, the first attempt to the assessment of horses exposure to TYR during nutritional supplementation was demonstrated by quantification of unbound TYR...
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Porównanie wyników pomiarów mas ziemnych wykonanych metodą skaningu laserowego i GNSS w kontekście inwestycji komunikacyjnych
PublikacjaPomiary objętości mas ziemnych to jeden z etapów związanych z robotami ziemnymi wynikającymi z planowania i prowadzenia inwestycji na danym obszarze. W przypadku inwestycji drogowych i kolejowych są szczególnie istotne, gdyż dąży się do zbilansowania robót ziemnych. Ważny jest także aspekt logistyczny – taki jak masowe przewozy materiałów sypkich (np. żwir). Zarówno przed jak i po wykonaniu robót ziemnych, niezbędny jest pomiar...
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Development and validation of GC–MS/MS method useful in diagnosing intestinal dysbiosis
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Rapid Evaluation of Poultry Meat Shelf Life Using PTR-MS
PublikacjaThe use of proton transfer reaction mass spectrometry (PTR-MS) for freshness classification of chicken and turkey meat samples was investigated. A number of volatile organic compounds (VOCs) were selected based on the correlation (> 95%) of their concentration during storage at 4 °C over a period of 5 days with the results of the microbial analysis. In order to verify if the selected compounds are not sample-specific, a number...
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LC-MS and LC-NMR as Complementary Techniques for the Determination of Pharmaceuticals in Dosage Formulations
PublikacjaPharmaceuticals contain not only pharmacologically active compounds but also a range of excipients. The danger exists that impurities may also be present in such drugs, which may adversely affect their efficacy and even endanger patient health and life. Monitoring the composition of pharmaceutical products is therefore essential. The trace amounts of such impurities in pharmaceuticals are often identified and determined with liquid...
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Functional properties of Cornelian cherry (Cornus mas L.): a comprehensive review
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Procedura dopuszczenia do eksploatacji maszyn do produkcji mas bitumicznych
PublikacjaW treści artykułu przedstawiono procedury postępowania przy uruchamianiu masbitumicznych. Ponadto opisano wymogi bhp na terenie wytwórni wraz z przeglą-dem aktualnym przepisów związanych z ochroną środowiska w tym odpadami pow-stającymi podczas produkcji, poziomu hałasu w środowisku maszyny i substan-cji zanieczyszczających powietrze.
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Robust HPLC–MS/MS method for levofloxacin and ciprofloxacin determination in human prostate tissue
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Preparation of Internal Standards for 2D-UPLC-MS/MS Quantification of Noncanonical DNA Bases
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Development and Validation of SPE-HPLC-MS/MS Method for Determining Cyclophosphamide in Surface Waters
PublikacjaA rapid and selective method for trace amounts determination of cyclophosphamide in surface water samples has been developed. A solid phase extraction SPE method for extraction and clean-up procedure has been optimized for determination by reversed-phase high-performance liquid chromatography with tandem mass spectrometry. The analyses proceed in the positive ion mode by means of the electrospray ionization method (ESI). Clean...
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Revealing dynamic changes of the volatile profile of food samples using PTR–MS
PublikacjaVolatile compounds carry valuable information regarding the properties of foodstuffs. Volatiles emitted from food can be used as, for example, indicators of quality, shelf-life, or authenticity. A better understanding of the multitude of transformations which occur during food processing could facilitate the optimisation of production, increase the desirability of food products, and also their wholesomeness. However, as some of...
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Recent advancements in LC‐MS based analysis of biotoxins: Present and future challenges
PublikacjaThere has been a rising concern regarding the harmful impact of biotoxins, source of origin, and the determination of the specific type of toxin. With numerous reports on their extensive spread, biotoxins pose a critical challenge to figure out their parent groups, metabolites, and concentration. In that aspect, liquid chromatography‐mass spectrometry (LC‐MS) based analysis paves the way for its accurate identification and quantification....
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A novel methodology for the enantiomeric resolution of methamphetamine, its precursors and intermediates by GC-MS
PublikacjaImpurity profiling and classification of abused drugs using chiral analytical techniques is of particular interest and importance because of the additional information obtained from this approach. When these methods are applied to the synthesis of illicitly used substances, they can supply valuable information about the conditions/chemicals used in the synthesis. In this study, simultaneous chiral separation of methylamphetamine,...
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LC–MS/MS analysis, antioxidant and anticholinergic properties of galanga (Alpinia officinarum Hance) rhizomes
PublikacjaGalanga (Alpinia officinarum Hance) is a pungent and aromatic rhizome, which is a member of the ginger family (Zingiberaceae). The rhizomes of this plant have been used as a traditional medicine in far east countries for relieving stomach ache, invigorating the circulatory system, treating colds, and reducing swelling. The aim of this study was to investigate antioxidant and anticholinergic properties of galanga. For this purpose,...
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Application for novel electrochemical screening of antioxidant potential and phytochemicals in Cornus mas extracts
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Freezing enhances the phytocompound content in cornelian cherry (Cornus mas L.) liqueur
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Mosty tymczasowe typu BAILEY - MS 22-80 w świetle badań in SITU
PublikacjaW pracy przedstawiono i omówiono zakres badań, wybrane modele obliczeniowe, wyniki analiz teoretycznych i badań odbiorowych (próbnych obciążeń o rozszerzonym zakresie), oraz spostrzeżenia dotyczące zachowania się konstrukcji na przykładzie kilku badanych obiektów mostów tymczasowych typu bailey - MS 22-80.
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HPLC–MS/MS method for dexmedetomidine quantification with Design of Experiments approach: application to pediatric pharmacokinetic study
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Quantification of methadone and its metabolites: EDDP and EMDP determined in autopsy cases using LC‐MS/MS
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Determination of odour concentration by TD-GC×GC–TOF-MS and field olfactometry techniques
PublikacjaField olfactometry is one of the sensory techniques used to determine odour concentration, in atmospheric air, directly in emission sources. A two-dimensional gas chromatography with time of flight mass spectrometer (GC×GC–TOF-MS) allows performing the chemical characterization of various groups of chemical compounds, even in complex mixtures. Application of these techniques enabled determination of odour concentration level in...
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Main strategies, analytical trends and challenges in LC-MS and ambient mass spectrometry-based metabolomics
PublikacjaA plethora of analytical LC-MS-based methods have been successfully applied to analyses of complex samples of various origin for metabolomics investigations. Over the last ten years, the substantial evolution of ambient mass spectrometry (AMS) techniques has highlighted their tremendous potential in metabolomic studies due to the minimal sample pretreatment requirement and the ability to analyse samples in their native state. This...
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Zastosowanie techniki LC-MS/MS oraz biotestów w analityce próbek środowiskowych w celu oznaczenia ich potencjału endokrynnego i zawartości wybranych związków endokrynnych
PublikacjaWyniki wielu badań prowadzonych w przeciągu ostatnich lat mogą stanowić podstawę do stwierdzenia, że zanieczyszczenia emitowane do środowiska ze źródeł antropogennych mogą stanowić kolejny rodzaj zagrożenia, z którego nie zdawano sobie sprawy wcześniej. Zanieczyszczeniami takimi są substancje z grupy EDC definiowane jako jakikolwiek czynnik, który wpływa na syntezę, wydalanie, transport, wiązanie, działanie lub wydalanie hormonów...
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Local ordering of nano-structured Pt probed by multiple-scattering XAFS
PublikacjaW pracy przedstawiono wyniki analizy MS EXAFS krystalicznej platyny i nanostruktur platyny (klastry o rozmiarach od 1nm do 7nm). Rezultaty analizy masowej platyny (uwzględniające rozkłady dwu i trój-ciałowe) są zgodne z wcześniejszymi danymi strukturalnymi i wibracyjnymi i stały się podstawą do realistycznej analizy EXAFS nanocząstek Pt realizownej w połączeniu z wynikami pomiarów TEM, SEM i XRD. Badaniom poddano nanocząstki Pt...
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Nano-structured Pt embedded in the acidic salts of heteropolymolybdate matrices: MS XAFS study
PublikacjaMultiple-scattering extended X-ray absorption fine structure (MS EXAFS) study combined with TEM and XRD analysis of a novel Pt-based catalyst operating at low temperature fuel cells (FCs) is presented. Innovation in the case of the considered catalyst resides in the use of a porous inorganic matrix of acidic heteropolymolybdate salts as a catalyst support. Obtained results show the relation between the matrix composition and the...
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LC-PDA-MS and GC-MS Analysis of Scorzonera hispanica Seeds and Their Effects on Human Breast Cancer Cell Lines
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Urine metabolic fingerprinting using LC–MS and GC–MS reveals metabolite changes in prostate cancer: A pilot study
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Quantification and distribution of 4-fluoroisobutyryl fentanyl (4-FiBF) in postmortem biological samples using UHPLC–QqQ-MS/MS
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Ekspertyza techniczna dot. stref zakotwień kabli sprężających – obiekt MS-6 w ciągu S7
PublikacjaOpracowanie zawiera wyniki badań i symylacji MES na temat stref zakotwień wewnętrznych kabli sprężenia podłużnego oraz wskazuje na przyczyny przemieszczenia biernych bloków kotwiących wewnętrznych kabli sprężenia podłużnego przęsła 7-8 mostu MS-6 zlokalizowanego w drogi krajowej S-7 na odcinku Miłomłyn – Olsztynek.
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RESIDUE ANALYSIS OF ETU AND PTU BY LC/MS
PublikacjaDithiocarbamates (DTCs) are important organosulfur compounds, which act as inhibitors of metal dependant and sulphydryl enzymes and have a serious consequence on biological systems. They possess variety of applications in agriculture as fungicides, as well as, in the rubber industry as vulcanization accelerators and antioxidants. In this way, DTCs are the main group of fungicides used to control approximately 400 pathogens of more...
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Nano-structured Pt embedded in acidic salts of heteropolymolybdate matrices: MS EXAFS study
PublikacjaA structural study of Pt nano-catalysts is presented in the paper. The innovation in the case of the considered catalytic materials resides in the use a meso-microporous inorganic matrix of heteropolyacid salt of composition X2.5H0.5YMo12O40 where X = Rb, Cs and Y = P, Si as a catalyst support. Metallic nanoparticles were created by platinum ions reduction in a hot H2/Argon stream and were mainly located into matrix pores. As the...
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Quantification of DNA Modifications Using Two-Dimensional Ultraperformance Liquid Chromatography Tandem Mass Spectrometry (2D-UPLC-MS/MS)
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Complementary use of GCxGC–TOF–MS and statistics for differentiation of variety in biosolid samples
PublikacjaFormation of biosolid cakes, which are one of the main wastes generated in wastewater treatment plants, is connected with emission of many hazardous chemical compounds, including odoriferous ones. To optimize particular processes of biosolid cake processing, it is necessary to assess chemical composition of the gas mixtures containing the compounds released from the cakes. The paper proposes application of two-dimensional gas chromatography...
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Fundamentals of Communication Networks Resilience to Disasters and Massive Disruptions
PublikacjaCommunication networks are exposed to a variety of massive failure events following from activities of nature, weather-induced disruptions, technology-implied problems, and malicious human activities. In this chapter, we first highlight the characteristics of these scenarios and discuss example failure events reported during the last three decades. Next, we explain the concept of network resilience and present an overview of major...
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3-Monochloropropane-1,2-diol in Infant Foods and Human Breast Milk: Determination by GC-MS
Publikacja3-Monochloropropane-1,2-diol is one of the food borne contaminants called chloropropanols. Over the last decade plenty of analytical methods was developed in order to determine 3-monochloropropane-1,2-diol in its free and bound form in various foodstuffs with the use of GC-FID, GC-ECD, LC-TOFMS and finally GC-MS, which is now widely used in laboratories. The aim of this research was the determination of 3-monochloropropane--1,2-diol...
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Electrochemistry/mass spectrometry (EC/MS) for fast generation and identification of novel reactive metabolites of two unsymmetrical bisacridines with anticancer activity.
PublikacjaThe development of a new drug requires knowledge about its metabolic fate in a living organism, regarding the comprehensive assessment of both drug therapeutic activity and toxicity profiles. Electrochemistry (EC) coupled with mass spectrometry (MS) is an efficient tool for predicting the phase I metabolism of redox-sensitive drugs. In particular, EC/MS represents a clear advantage for the generation of reactive drug transformation...
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Chiral analysis of chloro intermediates of methylamphetamine by one-dimensional and multidementional NMR and GC/MS
PublikacjaImpurity profiling and classification of abused drugs using chiral analytical techniques is of particular interest and importance because of the additional information obtained fromthis approach. When these methods are applied to the synthesis of illicitly used substances, they can supply valuable information about the conditions/chemicals used in the synthesis. We have applied GC and NMR methods to the study of intermediates found...
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Determining pesticide contamination in honey by LC-ESI-MS/MS - Comparison of pesticide recoveries of two liquid-liquid extraction based approaches
PublikacjaHoney, a valuable food product, may be contaminated by xenobiotics during its production and/or harvest. The determination of trace levels of contaminants in a complex matrix like honey still presents a challenge to analytical chemists. The aim of this work was to assess and compare the extraction efficiencies of 30 pesticide residues (acaricides, insecticides, herbicides, fungicides), belonging to over 15 different chemical classes....
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Extraction and Analysis of Bisphenols and Their Derivatives in Infant and Toddler Ready-to-feed Meals by Ultrasound-assisted Membrane Extraction Followed by LC MS/MS
PublikacjaThis research developed an ultrasound-assisted membrane extraction coupled with liquid chromatography-tandem mass spectrometry method for the determination of nineteen bisphenols and their derivatives in infant and toddler ready-to-feed meals. The calibration curves for all analytes were linear in the tested range, and the limit of detection and limit of quantitation were in the range 0.27 to 0.79 ng/g and 0.80 to 2.4 ng/g, respectively....
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MRM–MS of marker peptides and their abundance as a tool for authentication of meat species and meat cuts in single-cut meat products
PublikacjaThe abundance of protein markers in different types of meat cuts was explored in the context of authentication of raw meat (pork, beef and chicken) and processed meat products. Peptides originating from myoglobin (Mb) and myosin (My) were analyzed using multiple reaction monitoring mass spectrometry (MRM–MS). Analytical protocol was optimized for good repeatability (CV < 10%) and high sensitivity. The MS signal intensity of Mb...
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RP-HPLC WITH DETECTION BY MEANS OF ESI-MS AND UV FOR IDENTIFICATION OF CHROMATOGRAPHIC PEAKS OF SOME HYDROXY DERIVATIVES OF EPOXY RESIN
PublikacjaThe composition of products synthesized on the basis of ED-24 epoxy resin has been studied using a reversed phase high-performance liquid chromatography followed by an electrospray ionization mass spectrometry (RP-HPLC/ESI-MS). The synthesized products contain free hydroxy groups and such groups, as epoxy, peroxy, carboxy or acrylate.
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Substrate noise modeling in early floorplanning of MS-SOCs.
PublikacjaW pracy zaproponowano model częstotliwościowy bloków analogowych wrażliwych na zakłócenia oraz bloków cyfrowych generujących zakłócenia w systemach mieszanych realizowanych na wspólnym podłożu krzemowym. Zaproponowane modele zostały wykorzystane w oprogramowaniu optymalizującym rozmieszczenie bloków funkcjonalnych na struktórze krzemowej. Dzieki użyciu procedur optymalizacyjnych uzyskano znaczącą redukcje poziomu zakłóceń przy...