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Wyniki wyszukiwania dla: major depressive disorder
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A demand for innovation support in samll and medium-sized enterprises in the baltic sea region
Publikacjathe aim of the expertise is to analyze the actual demand of smes from the baltic sea region for innovation support. the results of the conducted study can help formulate recommendations designed to increase innovation and competitiveness of smes in the baltic sea region in the future. research activities of this study include: the evaluation of innovation level of the baltic sea region enterprises (type and intensity of implemented...
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Author Correction: Risk factors for serious morbidity, prolonged length of stay and hospital readmission after laparoscopic appendectomy - results from Pol-LA (Polish Laparoscopic Appendectomy) multicenter large cohort study
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The significant impact of age on the clinical outcomes of laparoscopic appendectomy
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Risk factors for serious morbidity, prolonged length of stay and hospital readmission after laparoscopic appendectomy - results from Pol-LA (Polish Laparoscopic Appendectomy) multicenter large cohort study
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Analityka surfaktantów w próbkach środowiskowych
PublikacjaSurfaktanty stanowią grupę związków charakteryzujących się specyficznymi właściwościami fizykochemicznymi (m.in. amfifilowa budowa, zdolność rozpuszczania się w cieczach o różnej polarności, zdolność do tworzenia micelli) i z tego względu są one wykorzystywane w wielu sferach działalności człowieka. Związki powierzchniowo-czynne ulegają różnorodnym przemianom fizykochemicznym, co umożliwia ich migrację między różnymi elementami...
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Metabolism of antitumour agent 1-nitroacridine derivative, C-1748 in pancreatic cancer cell lines
PublikacjaPancreatic cancer has the highest mortality rate of all major cancers because of limited treatment options. Surgical removal of the tumour is possible only in its early stage, nevertheless the asymptomatic development very often makes unable an accurate diagnose. In the case of metastatic pancreatic cancer only chemotherapy, mainly with gemcitabine, can be offered to patients. However, common resistance towards gemcitabine imposes...
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Induction of G2/M phase arrest and apoptosis of human pancreatic cancer BxPC-3 cells by potenet antitumor 1-nitroacridine derivative C-1748
PublikacjaPancreatic ductal adenocarcinoma (PDA) is among the most lethal human cancers, in part because it is insensitive to many chemotherapeutic drugs. Gemcitabine still remains the best chemotherapeutic agent available for the treatment of advanced pancreatic cancer. However, gemcitabine treatment results in only a marginal survival advantage. Thus, there is a strong need for the continuous development of novel therapeutic agents...
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Knowledge management strategies in KIBS companies: A preliminary analysis
PublikacjaPurpose – The aim of this paper is to perform a preliminary analysis concerning the detection and examination of two possible opposite approaches to KM planning which will be referred to as deliberate and emergent KM strategies. The goal is to enhance our understanding of the variety of features KM strategies possess and, accordingly, to formulate categorisations that are in line with such characteristics. Design/methodology/approach...
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Analysis of IPv6 handovers in IEEE 802.16 environment
PublikacjaThe second generation of WiMAX solutions, based on IEEE 802.16-2005 standard, offers limited mobility support. Unfortunately, after quickly changing the point of attachment on the WiMAX data link layer (DLL), very slow and inefficient IPv6 reconfiguration takes place. Delays introduced by automatic configuration (DHCPv6 and IPv6 protocols) and Mobile IPv6 can easily diminish or even render useless all benefits gained using the...
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Covalent DNA modification by products of myrosinase catalysed glucosinolate degradation in cell-free system
PublikacjaThe bioactive phytochemicals found in Brassica vegetables belonging to glucosinolates (GLS) and especially the products of their degradation isothiocyanates (ITC) and indoles are regarded as the most promising cancer chemopreventive compounds. These secondary metabolites constitute defence system repelling or preventing the development of agrophages attacking brassica plants. The antibiological properties of these compounds suggest...
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Surface water quality assessment by the use of combination of multivariate statistical classification and expert information
PublikacjaThe present study deals with the assessment of surface water quality from an industrial-urban region located in northern Poland near to the city of Gdansk. Concentrations of thirteen chemicals includingtotal polycyclic aromatic hydrocarbons (PAHs), halogenated volatile organic compounds (HVOCs) and major ions in the samples collected at five sampling points during six campaigns were used as variablesthroughout the study. The originality...
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Circularly Polarized Antenna Array design with the Potential of Gain-Size Trade-off and Omnidirectional Radiation for Millimeter-Wave Small Base Station Applications
PublikacjaThis paper presents the design and validation of a slot-patch-hybrid circularly polarized antenna array for 28 GHz millimeter (mm) wave (mm-wave) applications. The proposed design has a simple geometry that facilitates the fabrication process, which is otherwise a challenging task due to the sub-mm dimensions of the circuit in the mm-wave band. In the proposed structure, aperture-coupled series slot-fed array is utilized to excite...
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H2O˙+ and OH+ reactivity versus furan: experimental low energy absolute cross sections for modeling radiation damage
PublikacjaRadiotherapy is one of the most widespread and efficient strategies to fight malignant tumors. Despite its broad application, the mechanisms of radiation-DNA interaction are still under investigation. Theoretical models to predict the effects of a particular delivered dose are still in their infancy due to the difficulty of simulating a real cell environment, as well as the inclusion of a large variety of secondary processes. This...
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Glucosinolates from lepidium peruvianum as potential antiamnestic drugs
PublikacjaLepidium peruvianum (maca) (Brassicaceae) is a naturally occurring plant mainly in the high Andes of Peru. In recent years, it has been intensively researched in terms of its influence on various diseases and towards health improvement. Alzheimer’s disease is an incurable disease that most often affects adults over the age of 60. As since 2003 the US Food and Drug Administration (FDA) did not approve any new drug for Alzheimer’s...
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Study of a Multicriterion Decision-Making Approach to the MQL Turning of AISI 304 Steel Using Hybrid Nanocutting Fluid
PublikacjaThe enormous use of cutting fluid in machining leads to an increase in machining costs, along with different health hazards. Cutting fluid can be used efficiently using the MQL (minimum quantity lubrication) method, which aids in improving the machining performance. This paper contains multiple responses, namely, force, surface roughness, and temperature, so there arises a need for a multicriteria optimization technique. Therefore,...
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Challenges associated with development of AUV - unmanned autonomous underwater vehicles to be operated using the AI-based control systems
PublikacjaThe last decade has been devoted towards further development of the UUV unmanned underwater vehicles which may be of two types. There are the USV unmanned surface vehicles and UUV unmanned underwater vehicles. There is a growing interest to work out and implement the fully advanced AUV autonomous underwater vehicles. The main drivers towards development of such the vehicles are the technologies of autonomous systems, sensors and...
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Urban Mentoring as a new polish management technique in participatory planning
PublikacjaA decade of experience in implementation of numerous urban modernization projects in Poland resulted in a lively debate on socialization of the planning process, in which the matter of the public space quality has become the center of gravity. In those years, transformation from the classic administrative model of „bureaucracy planning” to the model of „management planning” has not been complete. The socialist primacy of the public...
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Accurate Modeling of Antenna Structures by Means of Domain Confinement and Pyramidal Deep Neural Networks
PublikacjaThe importance of surrogate modeling techniques has been gradually increasing in the design of antenna structures over the recent years. Perhaps the most important reason is a high cost of full-wave electromagnetic (EM) analysis of antenna systems. Although imperative in ensuring evaluation reliability, it entails considerable computational expenses. These are especially pronounced when carrying out EM-driven design tasks such...
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Long-Term Impact of Wind Erosion on the Particle Size Distribution of Soils in the Eastern Part of the European Union
PublikacjaWind erosion is the leading cause of soil degradation and air pollution in many regionsof the world. As wind erosion is controlled by climatic factors, research on this phenomenon isurgently needed in soil and land management in order to better adapt to climate change. In thispaper, the impact of wind erosion on the soil surface in relation to particle size distribution wasinvestigated. Changes in percentage of sand, silt and...
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Methodology for Processing of 3D Multibeam Sonar Big Data for Comparative Navigation
PublikacjaAutonomous navigation is an important task for unmanned vehicles operating both on the surface and underwater. A sophisticated solution for autonomous non-global navigational satellite system navigation is comparative (terrain reference) navigation. We present a method for fast processing of 3D multibeam sonar data to make depth area comparable with depth areas from bathymetric electronic navigational charts as source maps during...
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Impact of Large-scale urban interventions on contemporary city centers. Gdansk case study. Wpływ przedsiewzięć urbanistycznych dużej skali na centra miast. Studium przypadku Gdańska
PublikacjaLarge scale urban interventions have become a common development practice in cotemporary cities, allowing achieving rapid changes in their urban structure. They can be analyzed taking into account various perspectives. Some of them include planning and development models, transformation of brownfields and other types of distressed urban areas, as well as consequences and results of their implementation in existing urban structures....
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A hybrid model of flooding of the ro-ro ships in damaged conditions
PublikacjaThe paper presents some results on investigations concerning development of a hybrid model for assessment of performance of the ro‐ro ships in damaged conditions. The model is devoted towards assessing the performance of the damaged ro‐ro ships at the preliminary stage of design. The key problems associated with preparing of such the model are associated with working out a method of assessment of the damaged roro ships performance,...
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Functionalized polyolefins, synthesis application and industrial relevance
PublikacjaPolymers play a key role in our modern life full of technical advances and a continuous request for new materials with tailored properties for a low price. Their excellent mechanical properties, good processability, chemical stability and low price make polyolefins the polymers of choice for most commodity and some more specialized applications. As a result, polyolefins account for over 65% of the total world demand of plastic...
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Measurement report: Spatial variations in ionic chemistry and water-stable isotopes in the snowpack on glaciers across Svalbard during the 2015–2016 snow accumulation season
PublikacjaThe Svalbard archipelago, located at the Arctic sea-ice edge between 74 and 81∘ N, is ∼60 % covered by glaciers. The region experiences rapid variations in atmospheric flow during the snow season (from late September to May) and can be affected by air advected from both lower and higher latitudes, which likely impact the chemical composition of snowfall. While long-term changes in Svalbard snow chemistry have been documented in...
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Political Sources of Government Redistribution in High-Income Countries
PublikacjaIn cross-national empirical work on income inequality and government redistribution, the greatest emphasis has been on the extremes of the income scale. Less work has been done on groups that are neither rich nor poor—the middle class. The lack of attention to this group is unfortunate for several reasons. Most obviously, the middle class, if defined as the three middle income quintile groups, is by far the largest income group,...
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Metabolomic and antioxidant properties of different varieties and origins of Dragon fruit
PublikacjaDragon fruit has appealed much concern from consumers as a novelty fruit with potent nutritional and medicinal benefits. Dragon fruit quality warrants comprehensive evaluation, based on the contents of pigments and health- promoting natural compounds in different varieties. This study was aimed to evaluate the differences among dragon fruit varieties extracted with methanol–water (CD3OD-D2O) and methanol (CD3OD) by proton nuclear magnetic...
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Impact response of two-layered grouted aggregate fibrous concretecomposite under falling mass impact
PublikacjaTwo-layered Grouted Aggregates Fibrous Concrete Composite (TGAFCC) is a new category concrete which became popular recently and attracted the attention of researchers globally. Recent studies indicated that TGAFCC has notable improvement in mechanical properties, which has been sufficiently documented. However, the impact behaviour of TGAFCC when combined with Glass Fibre Mesh (GFM) and Textile Fibre Mesh (TFM) is still unexplored....
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A Novel Versatile Decoupling Structure and Expedited Inverse-Model-Based Re-Design Procedure for Compact Single-and Dual-Band MIMO Antennas
PublikacjaMultiple-input multiple-output (MIMO) antennas are considered to be the key components of fifth generation (5G) mobile communications. One of the challenges pertinent to the design of highly integrated MIMO structures is to minimize the mutual coupling among the antenna elements. The latter arises from two sources, the coupling in the free space and the coupling currents propagating on a ground plane. In this paper, an array of...
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Preprzedsiębiorczość
PublikacjaKsiążka składa się z czterech rozdziałów, poprzedzonych wstępem i zwieńczonych częścią podsumowującą całość. Rozdział pierwszy nakreśla tło dla dalszych rozważań. W rozdziale tym wyodrębniono trzy zasadnicze ujęcia: ujęcie ekonomiczne, ujęcie psychologiczne oraz socjologiczno-kulturowe. W dalszej części tego rozdziału przeanalizowano związki między przedsiębiorczością a wzrostem gospodarczym. Wskazano także mniej znane kierunki...
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URBAN MENTORING JAKO NOWA TECHNIKA WPRÓŁPRACY W PROCESIE PLANOWANIA PARTCYPACYJNEGO
PublikacjaW 25 lat od powrotu demokracji opierającej się o neoliberalny paradygmat rozwoju kraju, Polska przyjęła Krajową Politykę Miejską 2030. Wraz z ustawą o rewitalizacji w nowoczesny sposób określa ona pole współpracy władz samorządowych i administracji z mieszkańcami, przejście do drugiej fazy rozwoju społeczeństwa demokratycznego – mieszkańców współgospodarzy przestrzeni miast. Powolna ewolucja tej relacji, silnie obarczonej dziedzictwem...
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Economic Vitality of Polish Suburbs
PublikacjaFor over 25 years, Poland has been undergoing major political, social and economic transformations. The country's system changed from a planned economy to a free-market, neo-liberal one. The effects of these changes are visible on several levels, including the field of urban planning, where they manifested themselves as the birth of the suburbanization process. In the field of economics, it could be noticed that since 1989, the...
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Medium-Voltage Drives: Challenges and existing technology
PublikacjaThe article presents an overview of state-of-art solutions, advances, and design and research trends in medium-voltage (MV) drive technologies - and also discusses the challenges and requirements associated with the use of such drives. The choice and deployment of MV drives in industries are associated with numerous requirements related to the front-end converter (grid side) and inverter (machine side). The focus is on solutions...
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The II phase metabolism of endogenous and exogenous compounds, including antitumor chemotherapeutics
PublikacjaThe II phase metabolism, it is a set of metabolism and excretion pathways of endogenous as well as exogenous compounds including xenobiotics. UDP-glucuronyltransferases (UGTs; EC 2.4.1.17) are the most crucial representatives of II phase enzymes, which are responsible for the transformation of bilirubine and bile acids, steroids and thyroid hormones and lipids. Exogenous compounds, including drugs, carcinogens, environmental pollutants...
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Wpływ barier ochronnych na poziom bezpieczeństwa ruchu drogowego
PublikacjaWypadki drogowe wciąż stanowią znaczną przyczynę zgonów, dlatego bardzo ważnym jest odpowiednie kształtowanie otoczenia drogi – by mogło ono uzyskać miano „wybaczającego”. Artykuł stanowi wprowadzenie do tematyki drogowych barier ochronnych, i jest częścią pracy dyplomowej realizowanej na Politechnice Gdańskiej, w ramach której autorzy analizują zależności pomiędzy wypadkami a omawianymi urządzeniami BRD. W artykule przedstawiono...
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The optimal mixture of Toxoplasma gondii recombinant antigens (GRA1, P22, ROP1) for diagnosis of ovine toxoplasmosis
PublikacjaToxoplasmosis, caused by Toxoplasma gondii, is the major parasitic disease affecting sheep. Infection not only results in significant reproductive losses in these animals, but has public health implications since consumption of infected meat can facilitate zoonotic transmission. Although several serological tests are currently used for diagnosis of ovine toxoplasmosis, production of reliable reagents is a constraint and therefore...
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Sampling-based novel heterogeneous multi-layer stacking ensemble method for telecom customer churn prediction
PublikacjaIn recent times, customer churn has become one of the most significant issues in business-oriented sectors with telecommunication being no exception. Maintaining current customers is particularly valuable due to the high degree of rivalry among telecommunication companies and the costs of acquiring new ones. The early prediction of churned customers may help telecommunication companies to identify the causes of churn and design...
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Usability of Mobile Applications: A Consolidated Model
PublikacjaMobile devices have become an integral part of the digital ecosystem, connecting people, businesses, and information around the world in ways never before possible. In particular, smartphones, tablets and other handheld devices equipped with mobile applications have changed every aspect of our lives. Today, a user can choose from nearly five million applications available for both Android and iOS operating systems. However, only...
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The usefulness of Toxoplasma gondii MIC1-MAG1-SAG1 chimeric antigen in the serodiagnosis of ovine toxoplasmosis
PublikacjaToxoplasmosis is a zoonotic disease caused by the protozoan Toxoplasma gondii, which infects humans and most warm-blooded animals throughout the world. Although human toxoplasmosis in healthy adults is usually asymptomatic, a serious disease can occur in the case of congenital infection and immunocompromised individuals. Among food animals, sheep, along with goats and pigs, possess the highest incidence of T. gondii cysts in meat,...
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Regulation of LPS assembly via controlled proteolysis and sensing of LPS stress in Escherichia coli
PublikacjaLipopolysaccharide (LPS) is a complex glycolipid, essential for the bacterial viability and along with phospholipids, it constitutes the major amphiphilic component of outer membrane (OM) in most of the Gram-negative bacteria, including Escherichia coli. LPS molecules confer an effective permeability barrier to the OM and play a crucial role in bacteria-environment and -host interactions. The synthesis and accumulation of this...
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On the influence of shell element properties on the response of car model in crash test
PublikacjaIt goes without saying that numerical simulations play important role in the modern engineering practice. Contemporary CAD environments combined with FEM solvers, along with computer power of modern processors, give the engineer fast and efficient tool. Ultimately, however it is the user alone who is responsible for the correctness of the results. As long as the FEM calculations remain in the sphere of academic exercise, the inevitable...
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Study of Multi-Class Classification Algorithms’ Performance on Highly Imbalanced Network Intrusion Datasets
PublikacjaThis paper is devoted to the problem of class imbalance in machine learning, focusing on the intrusion detection of rare classes in computer networks. The problem of class imbalance occurs when one class heavily outnumbers examples from the other classes. In this paper, we are particularly interested in classifiers, as pattern recognition and anomaly detection could be solved as a classification problem. As still a major part of...
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Nutrient loss from three small-size watersheds in the southern Baltic Sea in relation to agricultural practices and policy
PublikacjaAgriculture is the major contributor of waterborne nutrient fluxes into the Baltic Sea, one of the world’s most eutrophication-sensitive areas. Poland, as a large, densely populated state ohf the Baltic Region, with dominating agricultural land use, largely contributes to riverborne loads of N and P. The aim of our study was to examine the input of nutrients from three small first-order agricultural watersheds (Bladzikowski Stream,...
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The added value of using the HEPA PAT for physical activity policy monitoring: a four-country comparison
PublikacjaBackground Public policy is increasingly recognized as an important component of physical activity promotion. This paper reports on the current status of physical activity policy development and implementation in four European countries based on the Health-Enhancing Physical Activity Policy Audit Tool (HEPA PAT) developed by WHO. It compares the findings to previous studies and discusses the general utility of this tool and its...
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Regulated assembly of lipopolysaccharide and sensing of its alterations in Escherichia coli
PublikacjaThis thesis describes mechanism of the regulation of the transcription of the rpoE gene encoding an essential RNA polymerase subunit in Escherichia coli. The RpoE regulates extracytoplasmic stress response regulon and is required to initiate transcription of genes, whose products are involvedin the folding of periplasmic proteins and synthesis and transport of outer membrane components. The transcriptional regulation of the rpoE...
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Evaluating the challenges and needs of parents caring for children with Williams syndrome: A preliminary study from Poland
PublikacjaBackground: Although physical, cognitive and behavioural manifestations of Williams syndrome(WS) affect every dimension of caregivers lives, no studies on the parental experiences of caringfor a WS child have to date been carried out in Poland.Methods: In order to identify the challenges and needs of Polish carers of WS children a survey wasconducted...
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Performance Analysis and Quantification of BeiDou Navigation Satellite System (BDS-3)
PublikacjaPositioning, Navigation, and Timing (PNT) information play a vital role in everyday life of common persons. People greatly rely on Global Navigation Satellite System (GNSS)-enabled applications for navigation to reach their desired destination. However, GNSS navigation performance is highly degraded in urban environments due to the high probability of signal interruption, multipath (MP), and/or non-line-of-sight (NLOS) signal...
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Electrochemistry meets enzymes: Investigation of the biotransformation pathway of C-1311 based on electrochemical simulation in comparison to in vitro methods.
PublikacjaThe knowledge of the metabolic pathways and the biotransformation of new drugs is one of the major challenges in pharmaceutical research. It is crucial for elucidation of degradation routes of the new biologically active compounds, especially in the area of possible toxicity. Conventional in vitro drug metabolism studies are based on incubating drug candidate with e.g. hepatocytes or, most importantly, liver cell microsomes and...
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Peptide Permeases in Candida albicans
PublikacjaAims: The aim of this work was to characterize oligopeptide uptake in Candida albicans mutants in which the genes encoding putative peptide permeases were selectively disrupted. Initial velocities of transport of model oligopeptides, (Ala)2, (Ala)3, (Ala)4, and sensitivity of mutants to antifungal oligopeptides containing N3-(4-methoxyfumaroyl)-L-2,3-diaminopropanoic acid (FMDP) were determined and compared to those of the wild-type...
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Circulating miRNA profiles and the risk of hemorrhagic transformation after thrombolytic treatment of acute ischemic stroke: a pilot study
PublikacjaBackground: Hemorrhagic transformation (HT) in acute ischemic stroke is likely to occur in patients treated with intravenous thrombolysis (IVT) and may lead to neurological deterioration and symptomatic intracranial hemorrhage (sICH). Despite the complex inclusion and exclusion criteria for IVT and some useful tools to stratify HT risk, sICH still occurs in approximately 6% of patients because some of the risk factors for this...
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The bile salt/phospholipid ratio determines the extent of in vitro intestinal lipolysis of triglycerides: Interfacial and emulsion studies
PublikacjaThis study focused on the protein-stabilised triglyceride (TG)/water interfaces and oil-in-water emulsions, and explored the influence of varying molar ratios of bile salts (BSs) and phospholipids (PLs) on the intestinal lipolysis of TGs. The presence of these two major groups of biosurfactants delivered with human bile to the physiological environment of intestinal digestion was replicated in our experiments by using mixtures...