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Development of potent and effective SARS-CoV-2 main protease inhibitors based on maleimide analogs for the potential treatment of COVID-19
PublikacjaIn the present work, we report a new series of potent SARS-CoV-2 Main Protease (Mpro) inhibitors based on maleimide derivatives. The inhibitory activities were tested in an enzymatic assay using recombinant Mpro (3CL Protease from coronavirus SARS-CoV-2). Within the set of new Mpro inhibitors, 6e demonstrated the highest activity in the enzymatic assay with an IC50 value of 8.52 ± 0.44 mM. The IC50 value for Nirmatrelvir (PF-07321332,...
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The Belt and Road Initiative and export variety: 1996–2019
PublikacjaThis study examines the association between the Belt and Road Initiative (BRI) and export variety (EV). We propose three hypotheses on how BRI may foster export markets (destinations) or export product lines. The estimates are based on a dataset constructed specifically for this analysis, covering 183 countries and linked with trade data from 1996 to 2019. We apply the instrumental variable (IV) approach in regressions for covering the...
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Badania podwójnego izolatora wykorzystujacego złącza ferrytowych sprzężonych linii mikropaskowych
PublikacjaW niniejszej pracy zbadano możliwości realizacji układu warstwowego izolatora podwójnego. Układ taki jest kaskadowym połączenie dwóch izolatorów wykonanych z cyrkulatorów FCL(Ferrite Coupled Line) zrealizowanych w technice linii mikropaskowych. W ramach przeprowadzonych badań wykonano projekty sekcji FCL oraz pozostałych układów tworzących układ izolatora, a następnie wyznaczono jego charakterystyki rozproszenia. Uzyskane numerycznie...
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A possibility of vibration surveillance of the hybrid systems by the optimal control at energy performance index.
PublikacjaPraca poświęcona jest nadzorowaniu drgań niestacjonarnych układów mechanicznych modelowanych metodą elementów skończonych. W celu redukcji poziomu drgań wprowadzono zewnętrzne sygnały sterujące. Zdefiniowano uzmienniony w czasie energetyczny wskaźnik jakości. Uwzględnienie założenia o możliwości podziału układu na podukład modalny, podukład strukturalny oraz podukład łączący umożliwiło opis układu sterowanego we współrzędnych hybrydowych....
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Corrosion monitoring by frequency intermodulation technique employing Gabortransformation
PublikacjaMonitorowano proces korozji zachodzący na stali ST3S w środowisku obojętnym. Wykonane zostały badania harmoniczne techniką intermodulacji częstotliwościowej. W analizie harmonicznej zastosowana została nowa metoda czasowo-częstotliwościowej tzw. transformacji Gabora. Wykazane zostało, że transformacja Gabora może być przydatna w monitorowaniu korozji w warunkach dynamicznych. Transformacja Gabora pozwala na dobrą reprezentację...
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Vibration surveillance for efficient milling of flexible details fixed in adjustable stiffness holder
PublikacjaThe paper presents the results of research related to the possibility of using an intelligent workpiece holder with adjustable stiffness, during end milling process. Machining a one side supported flexible workpiece will be performed with constant spindle speed and feed speed. In order to avoid hazardous vibration, stiffness of the especially designed spring (mounted in a workpiece holder) will be modified off-line. In order to...
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Modelling of Nuclear Power Plant Steam Turbine
PublikacjaThe paper describes the approach to a Nuclear Power Plant steam turbine modelling which would enable on-line optimal process control (model based) and diagnosis over wide range of operating conditions caused by changing power demand. Presented model is static, multivariable and nonlinear. Such model enables analyzing the heat cogeneration aspects. Developed model is validated and verified by using archive data gained from researches...
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Modelling of Nuclear Power Plant Steam Turbine
PublikacjaThe paper describes the approach to a Nuclear Power Plant steam turbine modelling which would enable on-line optimal process control (model based) and diagnosis over wide range of operating conditions caused by changing power demand. Presented model is static, multivariable and nonlinear. Such model enables analyzing the heat cogeneration aspects. Developed model is validated and verified by using archive data gained from researches...
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Communication Networks in the Service of the Environmental Monitoring
PublikacjaIn the paper selected issues relating to communication networks in the services of the environmental monitoring (EM) have been described. It is divided into three main parts: introduction, wire and wireless networks. At the beginning of the basic definitions were explained. The wire part focuses on a plain old telephone service (POTS), an integrated services digital network (ISDN), a digital subscriber line (DSL) and a fiber-optic...
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An Overview of the Development of a Real-Time System for Endoscopic Video Classification
PublikacjaThe article presents the results of improving endoscopic image classification algorithms in an effort towards applying them in a real-time diagnosis supporting system. Methods for the detection and removal of personal data are presented and discussed. The currently developed recognition algorithms have been improved in terms of accuracy and performance to make them suitable for a real-life implementation. Their test results are...
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Correlation between charge density waves and antiferromagnetism in Nd1−xGdxNiC2 solid solutions
PublikacjaWe report a study on the evolution of a charge density wave and antiferromagnetism in the series of the polycrystalline solid solution Nd1−xGdxNiC2 (0 _ x _ 1) by means of magnetic and transport properties measurements. The experimental results reveal the violation of the de Gennes law and a strong correlation between the Peierls, Néel, and Curie-Weiss temperatures, which strongly suggests a cooperative interaction between the...
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Crack Detection in Metallic Surfaces Based on Dumbbell-Shaped Defected Ground Structures in Microstrip Technology
PublikacjaIn this paper, a novel crack detection sensor using a microstrip loaded with a Dumbbell-Shaped Defected Ground Structure (DS-DGS) is proposed. The sensing element is etched in the ground plane of a microstrip line and it is easy to fabricate. The electromagnetic (EM) field of the microstrip couples to the DS-DGS, thus demonstrating a bandstop behavior. It is shown that in the presence of a crack in a metallic surface underneath the...
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Uwarunkowania rozwoju e-administracji w Polsce
PublikacjaCelem opracowania są w szczególności: - Ocena poziomu rozwoju e-administracji w Polsce oraz innych, w szczególności europejskich, krajach w okresie transformacji. - Identyfikacja i ocena wpływu czynników determinujących poziom rozwoju e-administracji. - Wskazanie korzyści wynikających ze stosowania rozwiązań e-administracji oraz barier w ich wdrażaniu. - Identyfikacja problemów i niespójności w planowaniu i realizacji e-usług publicznych. -...
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Effect of tube bundle arrangement on performance of shell-and-tube latent heat storage system
PublikacjaThis work presents the results of experimental investigation on charging and discharging of latent heat storage systems (LHSS) in the form of shell-and-tube heat exchangers with a variable arrays of the tube bundles. The tests included two tube arrangements – in-line and triangular (staggered), a variable number of tubes in a bundle, two pitch ratios, and different tube positions in a bundle. Three commercial products (LTP56, RT54HC,...
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A standardised static in vitro digestion method suitable for food – an international consensus
PublikacjaSimulated gastro-intestinal digestion is widely employed in many fields of food and nutritional sciences, as conducting human trials are often costly, resource intensive, and ethically disputable. As a consequence, in vitro alternatives that determine endpoints such as the bioaccessibility of nutrients and non-nutrients or the digestibility of macronutrients (e.g. lipids, proteins and carbohydrates) are used for screening and building...
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5-Selenocyanato and 5-trifluoromethanesulfonyl derivatives of 2′-deoxyuridine: synthesis, radiation and computational chemistry as well as cytotoxicity
Publikacja5-Selenocyanato-2′-deoxyuridine (SeCNdU) and 5-trifluoromethanesulfonyl-2′-deoxyuridine (OTfdU) have been synthesized and their structures have been confirmed with NMR and MS methods. Both compounds undergo dissociative electron attachment (DEA) when irradiated with X-rays in an aqueous solution containing a hydroxyl radical scavenger. The DEA yield of SeCNdU significantly exceeds that of 5-bromo-2′-deoxyuridine (BrdU), remaining...
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Novel steroid sulfatase inhibitors based on N ‐thiophosphorylated 3‐(4‐aminophenyl)‐coumarin‐7‐O‐sulfamates
PublikacjaIn the present work, we described convenient methods for the synthesis ofN-thiophosphorylated 3-(4-aminophenyl)-coumarin-7-O-sulfamates as steroid sulfatase(STS) inhibitors. To design the structures of the potential STS inhibitors, molecularmodeling techniques were used. A computational docking method was used to deter-mine the binding modes of the synthesized inhibitors as well as to identify potentialinteractions between specified...
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The resistance of S235JR steel to cavitation erosion
PublikacjaThe erosion resistance of S235JR steel to flow cavitation was investigated. In order to understand an influence of steel properties and cavitation intensities on the degradation mechanisms, low-carbon S235JR steel was tested in the as-received state and after thermal treatment (annealing) under four different flow velocities. Annealing decreased steel hardness, which made S235JR steel less resistant to cavitation erosion. The performed...
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Multi-Temporal Analysis of Changes of the Southern Part of the Baltic Sea Coast Using Aerial Remote Sensing Data
PublikacjaUnderstanding processes that affect changes in the coastal zone and the ability to predict these processes in the future depends on the period for which detailed monitoring is carried out and on the type of coast. This paper analyzes a southern fragment of the Baltic coast (30 km), where there has been no anthropogenic impact (Slowinski National Park). The study was carried out covering a time interval of 65 years. Historic and...
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Enhanced-Performance Circularly Polarized MIMO Antenna with Polarization/Pattern Diversity
PublikacjaDesign of a compact wideband circularly polarized (CP) multiple-input multiple-output (MIMO) antenna with polarization diversity is proposed and characterized for off-body communication. The antenna is based on a simple coplanar waveguide (CPW)-fed monopole extension of the microstrip line. The orthogonal field components required by CP are induced using a simply modified right/left side ground plane. In particular, a stub extending...
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Pomiar wartości opóźnienia hamowania dla sprawnego i niesprawnego układu hamulcowego
PublikacjaW artykule przedstawiono wyniki badań: sprawny układ hamulcowy i niesprawny układ hamulcowy. Pomiary opóźnienia hamowania przeprowadzono na suchej nawierzchni asfaltowej. Wykonano układ, który rozszczelnia przewód hamulcowy przy przednim prawym kole w czasie jazdy. Wykonano symulację wycieku płynu hamulcowego
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Ocena klimatu akustycznego w przestrzeni pasażerskiej elektrycznego zespołu trakcyjnego serii EN57
PublikacjaW pracy przedstawiono wyniki badań poziomów dźwięku w przestrzeni pasażerskiej elektrycznego zespołu trakcyjnego (EZT) serii EN57 podczas postoju, rozruchu, jazdy oraz hamowania. Badania przeprowadzono na podstawie autorskiej metodyki badawczej bazując na normie PNEN ISO 3381:Kolejnictwo. Akustyka. Pomiar hałasu wewnątrz pojazdów szynowych. Badania przeprowadzono na linii kolejowej nr 250 od przystanku Gdańsk Śródmieście do stacji...
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Przegląd badań na temat Wikipedii oraz z wykorzystaniem Wikipedii jako instrument badawczego
PublikacjaW badaniach dotychczas prowadzonych w Polsce Wikipedia była zarówno przedmiotem badań, jak i instrumentem badawczym. Badania na jej temat oraz na temat skutków społecznych jej używania prowadzili przedstawiciele nauk humanistycznych, społecznych, ekonomicznych i prawnych. Dla wielu badaczy (zwłaszcza z dziedziny informatyki) Wikipedia była instrumentem pomocnym w prowadzeniu różnorodnych analiz i dociekań naukowych. Niniejszy artykuł...
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Historic railway stations, documentation and revitalization of the railway infrastructure facilities - protection of cultural and social heritage
PublikacjaThe article presents problems of documentation and adaptation of buildings which constitute the cultural heritage of the railway infrastructure facilities in Pomerania in Poland. Shows the potential and possibilityto be adopted for various purposes. This problem affects many sites and buildings, railway stations, railway warehouses, residential buildings, technical buildings, water towers, trackman shelters, bridges, viaducts,...
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Video Analytics-Based Algorithm for Monitoring Egress from Buildings
PublikacjaA concept and practical implementation of the algorithm for detecting of potentially dangerous situations of crowding in passages is presented. An example of such situation is a crush which may be caused by obstructed pedestrian pathway. Surveillance video camera signal analysis performed on line is employed in order to detect hold-ups near bottlenecks like doorways or staircases. The details of implemented algorithm which uses...
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Content-Based Approach to Automatic Recommendation of Music
PublikacjaThis paper presents a content-based approach to music recommendation. For this purpose, a database which contains more than 50000 music excerpts acquired from public repositories was built. Datasets contain tracks of distinct performers within several music genres. All music pieces were converted to mp3 format and then parameterized based on MPEG-7, mel-cepstral and time-related dedicated parameters. All feature vectors are stored...
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The distributed model predictive controller for the nuclear power plant turbo-generator set
PublikacjaTypically there are two main control loops with PI controllers operating at each turbo-generator set. In this paper a distributed model predictive controller DMPC, with local QDMC controllers for the turbine generator, is proposed instead of a typical PI controllers. The local QDMC controllers utilize step-response models for the controlled system components. These models parameters are determined based on the proposed black-box...
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Research on causes of corrosion in the municipal water supply system
PublikacjaThis paper presents results of failure analysis study to characterize the corrosion damage that occurred in the water supply system in Krakow. This analysis includes: electrochemical noise, linear polarization and resistometric measurements. Water aggressiveness of four water intakes was defined using Langelier and Ryznar indices. Results from this indices did not reveal the causes of considerable corrosion losses in water systems....
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Establishment of the Right of Electricity Transmission Easement Through Court Proceedings
PublikacjaIncluding the amendment of the Civil Code Act on May 30, 2008, issues related to the right of easement of transmission were introduced to it. Such a regulation was necessary in view of the need to define the legal status of transmission facilities, existing and designed on real estate property. The purpose of the study is to analyze issues related to the definition of the spatial extent of the law of transmission easement for power...
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Mainstream shortcut N removal modeling current status and perspectives
PublikacjaThis work gives an overview of the state-of-the-art in modelling of short-cut processes for nitrogen removal in mainstream wastewater treatment and presents future perspectives for directing research efforts in line with the needs of practice. The modelling status for deammonification (i.e., anammox-based) and nitrite-shunt processes is presented with its challenges and limitations. The importance of mathematical models for considering...
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Robustness Analysis of a Distributed MPC Control System of a Turbo-Generator Set of a Nuclear Plant – Disturbance Issues
PublikacjaTypically, there are two main control loops with PI controllers operating at each turbo-generator set. In this paper, a distributed model predictive controller with local quadratic model predictive controllers for the turbine generator is proposed instead of a set of classical PI controllers. The local quadratic predictive controllers utilize step-response models for the controlled system components. The parameters of these models...
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Structure and optical parameters of Eu doped tellurium oxide thin films prepared by reactive magnetron sputtering method
PublikacjaIn this work the structural properties and photoluminescence of tellurium dioxide thin films doped by europium were described. Thin films were deposited by magnetron sputtering method and simultaneously heated at 200 °C. Presence of Eu ions and their valence states was confirmed by X-ray photoemission spectroscopy measurements. The structure of the films as well as the influence of europium dopant on crystalline structure of the...
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Nośność konstrukcji gruntowo-łukowej prefabrykowanego wiaduktu w świetle obliczeń numerycznych i badań „in situ”
PublikacjaWartykule przedstawiono analizy przeprowadzone dla wiaduktu WK-15 Pomorskiej Kolei Metropolitalnej wykonanego w technologii łuków prefabrykowanych przykrytych gruntem (system TechSpan). W celu weryfikacji obliczeń numerycznych wykonano próbne obciążenie konstrukcji. Przedstawiono wyniki pomiarów naprężeń i prezmieszczeń konstrukcji. Odniesiono się krytycznie do zastosowanego modelu obliczeniowego.
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Diagnostic testing of marine propulsion systems with internal combustion engines by means of vibration measurement and results analysis
PublikacjaIn this paper selected issues concerning vibration diagnosis of the mechanical system within marine propulsion units have been presented, carried out on the basis of experimental examinations of a real object in which an exceedance of the allowable vibration’s level had been observed. Used diagnosing system has been characterised. A procedure of longitudinal and transverse vibrations shaft lines of the mechanical system within...
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Generic emergence of classical features in quantum Darwinism
PublikacjaQuantum Darwinism posits that only specific information about a quantum system that is redundantly proliferated to many parts of its environment becomes accessible and objective, leading to the emergence of classical reality. However, it is not clear under what conditions this mechanism holds true. Here we prove that the emergence of classical features along the lines of quantum Darwinism is a general feature of any quantum dynamics:...
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Study of ultraviolet-visible fluorescence emission following resonant Auger decay of the 2p-1nl core-excited states of argon atoms
PublikacjaWe have studied the excitation and relaxation of Ar+ ions populated in resonant Auger decay from the Ar 2p−1nl core-excited states by using ultraviolet-visible fluorescence spectroscopy and photon-photon delayed coincidence technique. Fluorescence emission yields were measured in the photon energy range of 240-–255 eV for the 3s23p4(1D)5s(2D) → 3s23p4(1D)4p(2F) (393 nm) and 3s23p4(1D)4d(2F) → 3s23p4(1D)4p(2F) (335 nm) transitions...
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Synthesis and biological evaluation of novel analogues of batracylin with synthetic amino acids and adenosine: an unexpected effect on centromere segregation in tumor cells through a dual inhibition of topoisomerase IIa and Aurora B
PublikacjaIn the search for new anticancer agents we designed and synthesized batracylin derivatives with linking synthetic amino acid side chains of different lengths and adenosine. Unexpectedly, we have found that in water and the culture media adenosine–amino acid–BAT conjugates form supramolecular structures and this prevents these compounds from entering cells. Consequently, these compounds exerted no biological activity when tested...
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Generalized Chebyshev Bandpass Filters With Frequency-Dependent Couplings Based on Stubs
PublikacjaThis paper presents an accurate synthesis method for inline and cross-coupled generalized Chebyshev bandpass filters with frequency-dependent couplings implemented via open and short stubs. The technique involves the synthesis of a lumped-element prototy pe in the form of a coupling matrix with a frequency-dependent term and the conversion of this prototype to a distributed-element mode l composed of sections of TEM lines. This...
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Visualization of a lifeboat motion during lowering along ship’s side
PublikacjaThis paper presents description of a computer program for motion visualization of a lifeboat lowered along ship’s side. The program is a post-processor which reads results of numerical calculations of simulated objects’ motions. The data is used to create scene composed of 3D surfaces to visualize mutual spatial positions of a lifeboat, ship’s side and water waving surface. Since the numerical data contain description of a simulation...
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Chiral Pyrazolo[4,3-e][1,2,4]triazine Sulfonamides—Their Biological Activity, Lipophilicity, Protein Affinity, and Metabolic Transformations
PublikacjaReferring to our previous laboratory results related to the tyrosinase and urease inhibition by pyrazolo[4,3-e][1,2,4]triazine sulfonamides, we examined here in silico the mechanism of action at the molecular level of the investigated pyrazolotriazine sulfonamides by the molecular docking method. The studied compounds being evaluated for their cytotoxic effect against cancer cell lines (MCF-7, K-562) and for recombinant Abl and...
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Interpolation methods in GPR tomographic imaging of linear and volume anomalies for cultural heritage diagnostics
PublikacjaThis paper presents results of a ground penetrating radar (GPR) survey conducted in St. Joseph’s Church in Gdańsk, Poland. The aim of the study was to produce tomographic imaging of a renovated floor as well as the objects buried under the floor to detect linear and volume inclusions. The assumed track spacing was meaningfully greater than the single signal spacing in each track, which induced the need for interpolation methods...
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Protein overproduction alters exosome secretion in Chinese hamster ovary cells
PublikacjaDespite the abundance of available cell lines, nearly 70% of all recombinant therapeutic proteins today are produced in Chi-nese hamster ovary (CHO) cells. The impact of protein overproduction on the secretion of exosomes by CHO cells has been investigated here. Increased secretion of extracellular vesicles (EVs) by protein overexpressing CHO cells was demonstrated with protein content assay, nanoparticle tracking analysis, and...
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Who makes Europe
Publikacja"Obrzeża" seria obrazów Obrzeża to kompozycja złożona z obrazów akwarelowych, połączonych w poziomą linię o wysokości 10 cm, która narasta etapami, ciągle powiększając się. Jest to dość przewrotna opowieść o miejscach, bazująca na subiektywnej selekcji motywów przedstawionych za pomocą realistycznych odwzorowań zestawionych na zasadzie dyptyku z ich abstrakcyjnymi kontrapunktami.
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Wireless Networks as an Infrastructure for Mission-Critical Business Applications
PublikacjaDespite the dynamic growth of wireless network systems, their pres-ence in business-support infrastructure has been limited. In the article we provide an overview of generic corporate network architecture and examine usefulness of available wireless network solutions in such systems. Following this overview we analyze new wireless network architecture which currently undergoes standardization process - wireless mesh. It can result...
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Rotating rod and ball
PublikacjaWe consider a mechanical system consisting of an infinite rod (a straight line) and a ball (a massless point) on the plane. The rod rotates uniformly around one of its points. The ball is reflected elastically when colliding with the rod and moves freely between consecutive hits. A sliding motion along the rod is also allowed. We prove the existence and uniqueness of the motion with a given position and velocity at a certain time...
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Merging Images from Parallel Depth Cameras
PublikacjaIn this paper a problem of simultaneous information acquisition from multiple depth cameras is investigated, aiming at obtaining single overall picture containing information from all cameras. The experiments are carried out on Microsoft Kinect devices. A methodology for merging images from multiple positioned in a line cameras is proposed. The method is based on the concept of simulating a view of an imaginary camera covering...
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Novel topology of compact coplanar waveguide resonant cell low-pass filter
PublikacjaIn this study, a novel pseudoelliptic function low-pass filter (LPF) constituted by a compact coplanar waveguide resonant cell has been designed and manufactured. The lumped-element seven-pole prototype has been adequately realized by using complementary perturbations located both in signal line and ground plane metallization. The fabricated uniplanar LPF offers a compact size of 5.6 x 9.8 mm2, return loss better than 26 dB over...
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Merging Images From Parallel Depth Cameras
PublikacjaIn this paper a problem of simultaneous information acquisition from multiple depth cameras is investigated, aiming at obtaining single overall picture containing information from all cameras. The experiments are carried out on Microsoft Kinect devices. A methodology for merging images from multiple positioned in a line cameras is proposed. The method is based on the concept of simulating a view of an imaginary camera covering...
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Monitoring of n-butanol vapors biofiltration process using an electronic nose combined with calibration models
PublikacjaMalodours, by definition, are generally unpleasant, nuisance smells that are a mixture of volatile chemical compounds which can be perceptible even at low concentrations. Due to the more frequent occurrence of odour nuisance associated with the odour sensations, and thus the need to remove them from the air, deodorization techniques are commonly used. Biofiltration is one of the methods of reducing odorants in the air stream. In...
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An interval estimator for chlorine monitoring in drinking water distribution systems under uncertain system dynamics, inputs and chlorine concentration measurement errors
PublikacjaThe design of an interval observer for estimation of unmeasured state variables with application to drinking water distribution systems is described. In particular, the design process of such an observer is considered for estimation of the water quality described by the concentration of free chlorine. The interval observer is derived to produce the robust interval bounds on the estimated water quality state variables. The stability...