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Towards β-selectivity in functional estrogen receptor antagonists
PublicationBased on the benzo[b]naphtho[1,2-d]furan and benzo[b]naphtho[1,2-d]thiophene frameworks, a series of ligands with different basic side chains (BSCs) has been synthesized and pharmacologically evaluated. Also, their binding modes have been modelled using docking techniques. It was found that the introduction of a BSC in these systems brings about a decrease of affinity for both estrogen receptors α and β in an in vitro competitive...
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Health-Promoting Effects of Ethylene-Treated Kiwifruit ‘Hayward’ from Conventional and Organic Crops in Rats Fed an Atherogenic Diet
PublicationKiwifruit is a subtropical fruit that is very popular among consumers. Kiwifruit ‘Hayward’ (Actinidia deliciosa C.F. Liang et A.R. Ferguson) is an important source of bioactive compounds and possesses high antioxidant capacity, but its value can be changed during ripening. The aim of this study was to compare the levels of total polyphenols (TP), ascorbic acid (AA), and total antioxidant capacities (TACs) of ethylene-treated and...
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Network society: a concept of smart information management
PublicationAutomatic enhancement of Internet broadcasted news has been recently gaining increasing importance and interest. Existing applications and models of textual Event Detection in online media are based on the analysis of news distributed via RSS (Rich Site Summary called also Really Simple Syndication) channels or available at news websites. It assumes that each piece of news is equally available to the reader and, therefore, describes...
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The Impact of Information and Communication Technology on the Rise of Urban Social Movements in Poland
PublicationThe chapter examines the relationship between the use of Information and Communications Technology (ITC) and the emergence of social movements focused on urban agenda in Poland. The aim is to investigate how and to what extent a growing body of smaller activist groups use opportunities provided by the ITC to achieve their political objectives. The research results indicate that Web-based media have helped to raise the profile...
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The Impact of Information and Communications Technology on the Rise of Urban Social Movements in Poland
PublicationThe chapter examines the relationship between the use of Information and Communications Technology (ITC) and the emergence of social movements focused on urban agenda in Poland. The aim is to investigate how and to what extent a growing body of smaller activist groups use opportunities provided by the ITC to achieve their political objectives. The research results indicate that Web-based media have helped to raise the profile of...
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Specific Binding of Cholesterol to the Amyloid Precursor Protein: Structure of the Complex and Driving Forces Characterized in Molecular Detail
PublicationC99 is the C-terminal membrane-bound fragment of the amyloid precursor protein that is cleaved by γ-secretase to release Aβ peptides, the hallmark of Alzheimer’s disease (AD). Specific interactions of C99 with cholesterol have been proposed to underlie the recognized role of cholesterol in promoting amyloidogenesis. By using molecular dynamics simulations, we studied cholesterol binding to C99 in a lipid bilayer. We determined...
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The Influence of the Co-Dopant Dexamethasone Phosphate on the Electrodeposition Process and Drug-Release Properties of Polypyrrole-Salicylate on Iron
PublicationIn this work, the influence of incorporation of two anti-inflammatory drugs dexamethasone phosphate and sodium salicylate on the electrodeposition process of polypyrrole (PPy) film on iron has been studied. The incorporation of the agents into PPy has been carried out in a one-step electropolymerization process on oxidizable iron. The role of each drug agent during the deposition process has been discussed. The morphological and...
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Numerical Study on Seismic Response of a High-Rise RC Irregular Residential Building Considering Soil-Structure Interaction
PublicationThe objective of the present study is to investigate the importance of soilstructure interaction effects on the seismic response of a high-rise irregular reinforced-concrete residential building. In order to conduct this research, a detailed three-dimensional structure model was subjected to various earthquake excitations, also including a strong mining tremor. Soil-foundation flexibility was represented using the spring-based...
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Active Power Quality Controllers
PublicationDynamic Static Synchronous Compensator is the most important controller for distribution networks and probably in SEEN. It has been widely used since the 1990s to regulate system voltage precisely, improve voltage profile, reduce voltage harmonics, reduce transient voltage disturbances and load compensation. Rather than using conventional capacitors and inductors combined with fast switches, the D-STATCOM uses a power-electronics...
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Selected aspects of the surface quality of the wooden elements after planing
PublicationThe quality of the surface of wooden elements, that have been planed, has got a crucial meaning in the whole production process flow, since the obtained effects affect the quality of wooden surface after painting. The emergence of defects in most cases causes need to qualify workpiece as a scrap part or additional work activity must be done. In the paper selected results of the investigation of the effect of the cutting tool wear...
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Improvement of opipramol base solubility by complexation with β-cyclodextrin
PublicationOpipramol (OPI), a tricyclic antidepressant and anxiolytic compound, is administered orally in the form of a dihydrochloride. Salt form of the drug has a higher solubility in water and hence bioavailability and stability. A similar effect can be achieved by closing the hydrophobic part of the drug molecule in the cyclodextrin cavity. The paper presents opipramol inclusion complexes with beta-cyclodextrin (β-CD) in 1:1 molar ratio....
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Regulacja epigenetyczna a potencjał regeneracyjny ssaków. Badania globalnych profili metylacji w tkankach dorosłej myszy MRL/MpJ i w sercach noworodków myszy C57BL/6J.
PublicationW pracy tej otrzymano genomowe profile metylacji DNA dla dwóch modeli regeneracji u ssaków: (i) dorosłej myszy MRL/MpJ, która jest zdolna do zamykania otworów w małżowinie usznej oraz wykazuje podwyższone zdolności regeneracyjne w wielu innych narządach oraz (ii) sercach noworodków myszy, u których zachodzi regeneracja rozległych uszkodzeń lewej komory serca. Zidentyfikowano szereg odmiennie metylowanych regionów DNA, regionów DMR,...
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RF Input-Quasi-Reflectionless Dispersive-Delay Structures Based on Complementary-Diplexer Circuits
PublicationA class of RF dispersive-delay structures (DDSs) with input-quasi-reflectionless behavior is reported. It is based on the exploitation of complementary-diplexer circuit networks, in which the out-of-band RF-input-power echoes reflected by the main bandpass-filter-(BPF)-type channel are dissipated by the resistively-terminated auxiliary bandstop-filter-(BSF)-type channel. Specifically, it is shown that the influence of the absorptive...
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Gelatin-Modified Polyurethanes for Soft Tissue Scaffold
PublicationRecently, in the field of biomaterials, which are being designed for soft tissue scaffolding, is growing the interest of their modification with natural polymers. Synthetic polymers are often hard, not easy to process and they do not possess fine biodegradable profile. From the other hand natural polymers are biocompatible, but weak when used alone. The combination of natural and synthetic polymers gives the suitable properties...
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Comprehensive two-dimensional gas chromatography for determination of the terpenes profile of blue honeysuckle berries
PublicationTerpenes are the main group of secondary metabolites, which play essential role in human. The establishment of the terpenes profile of berries of different blue honeysuckle cultivars was achieved by headspace solid-phase microextraction coupled with comprehensive two-dimensional gas chromatography with time-of-flight mass spectrometry (HS-SPME/GCGC-TOFMS). The berries were found to contain 44 terpenes identified by GCGC-TOFMS....
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An Ontology-based Contextual Pre-filtering Technique for Recommender Systems
PublicationContext-aware Recommender Systems aim to provide users with the most adequate recommendations for their current situation. However, an exact context obtained from a user could be too specific and may not have enough data for accurate rating prediction. This is known as the data sparsity problem. Moreover, often user preference representation depends on the domain or the specific recommendation approach used. Therefore, a big effort...
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Comparison of Average Energy Slope Estimation Formulas for One-dimensional Steady Gradually Varied Flow
PublicationTo find the steady flow water surface profile, it is possible to use Bernoulli’s equation, which is a discrete form of the differential energy equation. Such an approach requires the average energy slope between cross-sections to be estimated. In the literature, many methods are proposed for estimating the average energy slope in this case, such as the arithmetic mean, resulting in the standard step method, the harmonic mean and...
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Genetic and Epigenetic Aspects of Atopic Dermatitis
PublicationAtopic dermatitis is a heterogeneous disease, in which the pathogenesis is associated with mutations in genes encoding epidermal structural proteins, barrier enzymes, and their inhibitors; the role of genes regulating innate and adaptive immune responses and environmental factors inducing the disease is also noted. Recent studies point to the key role of epigenetic changes in the development of the disease. Epigenetic modifications...
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Estimating the uncertainty of discharge coefficient predicted for oblique side weir using Monte Carlo method
PublicationSide weir is a hydraulic structure, which is used in irrigation systems to divert some water from main to side channel. It is installed at the entrance of the side channel to control and measure passing water into the side channel. Many studies provided side weir water surface profile and coefficient of discharge to measure water discharge diverted into the side channel. These studies dealt with different side weir shapes (rectangular,...
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The influence of amorphous macrodiol, diisocyanate type and l-ascorbic acid modifier on chemical structure, morphology and degradation behavior of polyurethanes for tissue scaffolds fabrication
PublicationStudies described in this work were related to the bulk synthesis and characterization of polyurethanes (PURs) obtained with the use of cyclic 4,4′-methylene bis(cyclohexyl isocyanate) (HMDI) or linear 1,6-hexamethylene diisocyanate (HDI), amorphous α,ω-dihydroxy(ethylene-butylene adipate) macrodiol (PEBA), 1,4-butandiol (BDO) chain extender and dibutyltin dilaurate (DBTDL) catalyst. Obtained PURs were modified with l-ascorbic...
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A numerical analysis of the thermal effects in the jet impingement stagnation zone
PublicationMost of the flows occurring in the engineering systems are turbulent and their accurate numerical analysis is still challenging, especially when combined with the heat transfer. One of the methods of heat transfer enhancement is utilization of the turbulent impinging jets, which were recently applied also in the heat exchangers. Their positive impact on the heat transfer performance was proven, but many questions related to its...
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Discrimination of selected fungi species based on their odour profile using prototypes of electronic nose instruments
PublicationThe paper presents practical application of an electronic nose technique to fast and efficient discrimination of the samples of different fungi species such as: Penicillium chrysogenum, Cladosporium herbarum, Rhizopus oryzae, Alternaria alternata. Two prototypes of electronic nose instrument were utilized for investigation of discrimination capability with respect to odour profile of these fungi: the first prototype was based on...
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Sequence variants of p21 gene of the MRL/MpJ mouse: a possible association with the deficit of p21 protein and regenerative phenotype.
PublicationThe MRL/MpJ mouse is known for its enhanced regeneration abilities that manifested themselves by scarless ear-hole wound closure. The deficit of p21 found in the MRL is associated with the regenerative capacity as the p21 gene knockout in a mouse strain unrelated to the MRL mouse results in an ear-hole closure effect, similar to that observed in the MRL mouse. Cdkn1a gene encodes p21 protein, a cyclin-dependent kinase inhibitor,...
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Preparation and evaluation of 1,3-alternate 25,27-bis-(pentafluorobenzyloxy)-26,28-bis-(3-propyloxy)-calix[4]arene-bonded silics gel high performance liquid chromatography stationary phase
PublicationA 1,3-alternate 25,27-bis-(pentafluorobenzyloxy)-26,28-bis-(3-propyloxy)-calix[4]arene-bonded silica gel stationary phase (CalixBzF10) was synthesized, structurally characterized, and used as a selector in liquid chromatography. The selectivity study of this phase was done by using fluorine-containing compounds (fluorobenzenes, fluoro-pyrimidine bases), as well as non-fluorinated analytes (non-steroidal anti-inflammatory drugs,...
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RF Multi-Functional Input-Reflectionless Dispersive-Delay Structure With Sharp-Rejection Filtering Using Channelization Techniques
PublicationA class of RF multi-functional input-reflectionless dispersive-delay structure (DDS) with linear-type in-band groupdelay variation and sharp-rejection bandpass-filtering capability is reported. It exploits a two-branch-channelized/balanced-type circuit with similar low-order reflective DDS units inside its channels, which are connected through input/output 3-dB quadrature wideband couplers. The adopted DDS unit is based on a coupledresonator...
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Computational fluid dynamics simulation of heat transfer from densely packed gold nanoparticles to isotropic media
PublicationThis work aims to determine and compare heat generation and propagation of densely packed gold nanoparticles (Au NPs) induced by a resonant laser beam (532 nm) according to the Mie theory. The heat flux propagation is transferred into the materials, which here are: silica glass; soda-lime-silica glass; borosilicate glass; polymethyl methacrylate (PMMA); polycarbonate (PC); and polydimetylosiloxane (PDMS). This analysis aims to...
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Probing Local Structural Changes by Sharp Luminescent Infrared Nanophosphor for Application in Light-Emitting Diodes
PublicationCr3+-doped infrared phosphors are promising candidates for next-generation phosphor-converted infrared light-emitting diodes (LEDs) because they can, in principle, tune and convert the luminescence spectra from an LED chip. However, most studies focus on broad-band Cr3+-doped phosphors, and the control mechanism of Cr3+-doped phosphors with sharp line emissions remains ambiguous. Here, we report LiGa5(1–x)Al5xO8:Cr3+ phosphors...
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Bearing capacity of monotonically installed tapered piles in medium dense Fontainebleau sand
PublicationA series of installation of tapered piles in medium-dense Fontainebleau sand were performed in the geotechnical centrifuge at Gustave Eiffel University. The models of piles with three different shapes - straight profile (S), and with taper angle of 0.70 degrees (T1), and 1.4 degrees (T2) were used. The piles were instrumented with fiber optic wires on the shaft and load cell at the base. After monotonic installation, the models were...
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Pipeline System for Heat Transportation from Nuclear Power Plant – an Optimizing Approach
PublicationOver the last few years heat piping insulation technology and pump systems efficiency have been significantly improved. Reduced thermal losses encourage heat transportation over long distances. It provides an opportunity for increasing thermodynamic efficiency of Nuclear Power Plants (NPPs) that are often located in rural areas because of safety issues. It can be achieved by Combined Heat and Power (CHP) generation, as heat produced...
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Road texture influence on tyre rolling resistance
PublicationTyre performance, one of the critical factors for vehicle users, is strongly related to theroad surface characteristics, most notably to the pavement texture. Phenomena that occur at the tyre/road interface affect tyre friction (skid resistance), rolling resistance, tyre wear and tyre/road noise. This article deals with relationship between surface texture and rolling resistance of light and heavy vehicle tyres. Mean profile depth...
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Young shoots of red cabbage are a better source of selected nutrients and glucosinolates in comparison to the vegetable at full maturity
PublicationCruciferous vegetables are a valuable source of ingredients with health benefits. The most characteristic compounds of cruciferous vegetables with identified anticancer properties are glucosinolates. Young shoots and sprouts of red cabbage are becoming a popular fresh food rich in nutrients and bioactive compounds. The objective of this research was to determine, for the first time in a comprehensive approach, whether young shoots...
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On topology optimization of large deformation contact-aided shape morphing compliant mechanisms
PublicationA topology optimization approach for designing large deformation contact-aided shape morphing compliant mechanisms is presented. Such mechanisms can be used in varying operating conditions. Design domains are described by regular hexagonal elements. Negative circular masks are employed to perform dual task, i.e., to decide material states of each element and also, to generate rigid contact surfaces. Each mask is characterized by...
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Natural carbon-based quantum dots and their applications in drug delivery: A review
PublicationNatural carbon based quantum dots (NCDs) are an emerging class of nanomaterials in the carbon family. NCDs have gained immense acclamation among researchers because of their abundance, eco-friendly nature, aqueous solubility, the diverse functionality and biocompatibility when compared to other conventional carbon quantum dots (CDs).The presence of different functional groups on the surface of NCDs such as thiol, carboxyl, hydroxyl,...
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Serum bisphenol A concentrations correlate with serum testosterone levels in women with polycystic ovary syndrome
PublicationThe aim of this study was to determine serum bisphenol A (BPA) concentrations using high performance liquid chromatography with tandem mass spectrometry (HPLC–MS/MS) in women with polycystic ovary syndrome (PCOS) (n=106, age range 18–40 yrs) and to evaluate its potential impact on their hormonal and metabolic profile. The control group consisted of age- and BMI-matched 80 eumenorrheic women with no clinical or biochemical hyperandrogenism....
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FROM HARVESTING TO DISTILLATION - EFFECT OF ANALYTICAL PROCEDURES ON THE YIELD AND CHEMICAL COMPOSITION OF RHODODENDRON TOMENTOSUM (LEDUM PALUSTRE) ESSENTIAL OIL
PublicationRhododendron tomentosum possesses the anti-inflammatory, analgesic and antimicrobial properties, determined by the chemical composition of its essential oil. The effects of place (Miszewko, Lubichowo) and time of harvesting (June, November) as well as drying (air-drying, oven-drying, freeze-drying) and isolation (in Deryng, Clevenger and Likens-Nickerson apparatus) procedures on the yield and quality of R. tomentosum essential...
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Influence of the electrosynthesis conditions on the spontaneous release of anti-inflammatory salicylate during degradation of polypyrrole coated iron for biodegradable cardiovascular stent
PublicationIn this work, the spontaneous release of anti-inflammatory salicylate from polypyrrole (PPy) coated iron has been studied during degradation of the material in phosphate buffer saline at 37 C. The sodium salicylate was incorporated into PPy in a one-step electropolymerization process. The influence of the synthesis conditions such as sodium salicylate concentration, pyrrole concentration and deposition charge on drug release profile...
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International Competitiveness in the Economics Literature: A Bibliometric Study
PublicationThis paper has as its main aim to consolidate the state of the art of academic research on international competitiveness, based on a bibliometric study of the economics literature published over the past 70 years. Citation data is collected from the ISI WEB of Science website, Scopus and Google Scholar and is analysed using Histcite and Vosviewer software. The growth pattern of the international competitiveness literature is investigated...
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Assessment of the Steering Precision of a Hydrographic Unmanned Surface Vessel (USV) along Sounding Profiles Using a Low-Cost Multi-Global Navigation Satellite System (GNSS) Receiver Supported Autopilot
Publicationhe performance of bathymetric measurements by traditional methods (using manned vessels) in ultra-shallow waters, i.e., lakes, rivers, and sea beaches with a depth of less than 1 m, is often difficult or, in many cases, impossible due to problems related to safe vessel maneuvering. For this reason, the use of shallow draft hydrographic Unmanned Surface Vessels (USV) appears to provide a promising alternative method for performing...
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System oceny efektywności użytkowania aparatów słuchowych (Hearing aid use effectiveness evaluation system)
PublicationCelem rozprawy jest opracowanie metody oceny efektywności protezowania słuchu przy użyciu aparatów słuchowych, która pozwoli w łatwy sposób poddawać ocenie korzyść z użytkowania protez słuchowych w najbardziej typowych sytuacjach akustycznych. Przedstawiono genezę podjętych badań i na tej podstawie zaproponowano cele i tezy rozprawy doktorskiej. W pracy w pierwszej kolejności zawarto przegląd dotyczący rodzajów ubytku słuchu...
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Applying the Lombard Effect to Speech-in-Noise Communication
PublicationThis study explored how the Lombard effect, a natural or artificial increase in speech loudness in noisy environments, can improve speech-in-noise communication. This study consisted of several experiments that measured the impact of different types of noise on synthesizing the Lombard effect. The main steps were as follows: first, a dataset of speech samples with and without the Lombard effect was collected in a controlled setting;...
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Soil and groundwater contamination as a result of sewage sludge land application
PublicationThe leaching of chemical compounds (N-NO3, N-NH4, Norg, P-PO4, Ptot) and trace elements (Cd, Cu, Cr, Ni, Zn, and Pb) from sewage sludge and their migration through the soil profile was the subject of the study. The column experiments were carried out under atmospheric conditions corresponding to naturally occurring storm events - sewage sludge amended soil was irrigated with high rates of water. The column filter media used in...
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Miniature reconfigurable antenna
PublicationThis work concerns the design of a miniature, low-profile reconfigurable antenna based on Huygens metamaterial sources for frequency f0 = 2.45 GHz. Two planar Huygens sources were designed consisting of near-field resonators. Sources are excited from a specially designed reconfigurable control system. Thanks to the two PIN diodes, the system can realize two cardioid radiation characteristics with...
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Investigation of the Effect of the Rocket's Suborbital Flight on Biofilm, Enzymes and Biosynthesis on Autonomous, Modular and Scalable Platforms For Conducting Experiments of an Astrobiotechnological Nature
PublicationWith new incentives for human space exploration, biotechnological experiments in orbit became imperative. Answering this need, we build an autonomous, modular, and scalable platform that enables those experiments on rockets. We called it AMBER. The aim of the payload of the R6 suborbital rocket is to perform an experiment to study the influence of rocket flights on biofilm, molecular biology enzymes and biosynthesis using our platform....
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Comparative Analysis of Reactive Power Compensation Devices in a Real Electric Substation
PublicationA constant worldwide growing load stress over a power system compelled the practice of a reactive power injection to ensure an efficient power network. For this purpose, multiple technologies exist in the knowledge market out of which this paper emphasizes the usage of the flexible alternating current transmission system (FACTS) and presents a comparative study of the static var compensator (SVC) with the static synchronous compensator...
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Evaluation of Terpene Decomposition in Kaffir Lime Juice during Storage Using Gas Chromatography–Mass Spectrometry and Proton Transfer Reaction–Mass Spectrometry
PublicationKaffir lime juice, often treated as production waste, can be a good source of terpenes. These compounds undergo various decomposition processes under the influence of external factors, especially during transportation and storage. In this paper, it was possible to monitor changes in the terpene profile of kaffir lime juice under different storage conditions, namely, 4 ◦C, 20 ◦C, and 35 ◦C. The identification of key decomposition...
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Evaluation of Selected Heavy Metal Contaminants as Well as Nitrates and Nitrites in the Microgreens of Nigella (Nigella sativa L.), Safflower (Carthamus tinctorius L.), and Camelina (Camelina sativa L.) at Different Stages of Vegetation
PublicationMicrogreens are a new, rapidly growing group of foodstuffs. The decorative function of these is often accompanied by their use in traditional dishes. As microgreens are eaten at very early stages, when the development of the epidermis is at its minimum, the bioavailability of minerals will be found to be higher in microgreens then in mature vegetables. So, microgreens can be an excellent functional food, especially for mineral-deficient...
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Assessment of organic coating degradation via local impedance imaging
PublicationThe paper presents a new approach to organic coating condition evaluation at micrometer scale using localized impedance measurements. It is based on atomic force microscopy (AFM) in contact mode. Impedance is measured between conductive AFM tip and metal substrate covered with organic coating. A single-frequency voltage perturbation signal is applied between the electrodes and current response signal is registered. As the tip is...
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Negocjacyjna metoda generowania protokołu uzgodnień na platformie EBXML
PublicationCelem standardu ebXML jest ustanowienie globalnej platformy dla biznesu elektronicznego, umożliwiającej dowolnym przedsiębiorstwom( bez względu na ich wielkość i lokalizację)poszukiwanie partnerów handlowych i realizowanie transakcji kupna-sprzedaży w oparciu o wymianę dokumentów elektronicznych o strukturze logicznej opisanej w XML.Podstawą do nawiązania kontaktu przez dowolny podmiot jest publikowany przez niego w specjalnym...
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The impedance of hydrogen oxidation reaction in a proton exchange membrane fuel cell in the presence of carbon monoxide in hydrogen stream
PublicationEvaluation of performance of a proton exchange membrane fuel cell, which is affected by carbon monoxide that pollutes the hydrogen stream, was presented. This influence was studied for carbon monoxide concentration of 125–325 ppb, which are close to values specified in ISO 14687:2019 standard. Performed studies provided crucial information for further development of fuel cell as an energy source for automotive application. Impedance...
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Escherichia coli Strains with Virulent Factors Typical for Uropathogens were Isolated from Sinuses from Patients with Chronic Rhinosinusitis—Case Report
PublicationEscherichia coli were isolated from three patients with chronic rhinosinusitis (CRS) by intraoperative sinus tissue biopsy. Taking into account the unusual replicative niche and previous treatment failures, it was decided to focus on the virulence and drug resistance of these bacteria. The strains turned out to be multi-sensitive, but the rich virulence factors profile of bacteria typical for phylogenetic group B2 deserved attention....