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Synthesis and biological evaluation of novel analogues of batracylin with synthetic amino acids and adenosine: an unexpected effect on centromere segregation in tumor cells through a dual inhibition of topoisomerase IIa and Aurora B
PublicationIn the search for new anticancer agents we designed and synthesized batracylin derivatives with linking synthetic amino acid side chains of different lengths and adenosine. Unexpectedly, we have found that in water and the culture media adenosine–amino acid–BAT conjugates form supramolecular structures and this prevents these compounds from entering cells. Consequently, these compounds exerted no biological activity when tested...
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Isolation and characterization of Acid Soluble Collagen from the Skin of African Catfish (Clarias gariepinus), Salmon (Salmo salar) and Baltic cod (Gadus morhua)
PublicationAcid-soluble collagen (ASC) from the fish skin of African catfish (Clarias gariepinus), Salmon (Salmo salar) and Baltic cod (Gadus morhua) was extracted and characterized. The ASC extraction yield was 75%, 73% and 68%, respectively. The denaturation and melting temperatures of African catfish ASC (29.3°C and 100.0°C) were significantly higher than ASC of Salmon and Baltic cod (20.6°C and 90.5°C; 15.2°C and 86.7°C, respectively), assessed...
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Sounding of Layered Marine Bottom - Model Investigations
PublicationThe necessary actions connected with interpretations of examining of physical properties of sea bottom structure is developing of proper procedure of modeling of the layered structure. The implementation of the acoustic waves for the determination of seabed stratification requires a precise diagnosis of the topic from both the theoretical and practical side. Little differences between the parameters of sediments, as well as irregular...
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Rapid design closure of linear microstrip antenna array apertures using response features
PublicationA simple yet reliable approach to a rapid design closure of linear antenna array apertures at the electromagnetic (EM)-simulation level is proposed. Our methodology exploits an underlying array factor (AF) model suitably corrected by means of characteristic points (angles and levels) of the radiation pattern of the EM model of the antenna array aperture. This conveniently allows for controlling both the side lobe levels...
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Streaming Real-time Data in Distributed Dispatcher and Teleinformation Systems for Visualization of Multimedia Data of the Border Guard
PublicationSurveillance of the sea borders is a very important task for the Border Guard. Monitoring of country maritime border is an important task of the Border Guard. This task can be facilitated with the use of the technology enabling gathering information from distributed sources and its supervision and visualization. This task can be accomplished using a technology that allows to collect information from distributed sensors of different...
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Multibeam Echosounder and LiDAR in Process of 360-Degree Numerical Map Production for Restricted Waters with HydroDron
PublicationIn order to increase the safety of inland navigation and facilitate the monitoring of the coastal zone of restricted waters, a model of multi-sensory fusion of data from hydroacoustic and optoelectronic systems mounted on the autonomous survey vessel HydroDron will be developed. In the research will be used the LiDAR laser scanner and multibeam echosounder. To increase the visual quality and map accuracy, additionally side scan...
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SPECTRAL DYNAMIC ANALYSIS OF A STATIONARY JACK-UP PLATFORM
PublicationThe paper refers to the dynamic short-term response analysis of the Baltic steel drilling platform (see Fig.2) in a random sea-state represented by one-dimensional wave spectrum proposed by Striekalov and Massel and it is recommended for the Baltic Sea area. The Baltic drilling platform is a jack-up type platform for the exploration and exploitation of oil under the Baltic Sea. The analysis presented deals with the stationary...
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Ageing Workforce – a Challenge for Organizations
PublicationAgeing and its consequences are most frequently analysed in macroscale. If the analyses apply to enterprises, they usually cover working conditions or motivations of the seniors’ choice between continuing employment and retirement. The article discusses slightly different themes, namely the awareness of demographic changes, their consequences for the organization and the new professional role of older people in the new demographic...
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Analiza porównawcza protokołów routingu dla bezprzewodowych sieci ad hoc
PublicationNowe usługi oferowane przez bezprzewodowe sieci LAN (WLAN) obejmują również wspieranie mobilności stacji końcowych. Prawidłowe funkcjonowanie ruchomych sieci WLAN wymaga oczywiście implementacji efektywnych metod routingu. By rozwiązać ten problem, IETF powołała grupę roboczą MANET (Mobile Ad Hoc Net-working Working Group). Zgodnie ze specyfikacją RFC 2501, sieć MANET jest zbiorem komunikujących się bezprzewodowo urządzeń, mogących...
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Impulsywne smarowanie biołożyska w mikrosekundach po udarze.
PublicationSmarowanie stawów człowieka, dokonujące sie na zasadzie tarcia mieszanego lub płynnego a nawet granicznego, jest ściśle uzależnione od czasu trwania ruchu a w szczególności uzewnętrznia się ta zależność w sytuacji zaistniałego udaru. W czasie udaru lub silnego impulsu siły uderzeniowej, wysokość szczeliny stawu zmienia się gwałtownie, w związku z tym zmieniają się istotne parametry smarowania powierzchni stawowych. Te fakty mają...
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New approach based on solid-phase extraction for the assessment of organic compound pollutions in so-called pharmaceutically pure water
PublicationOpisano mozliwość zastosowania nowej procedury analitycznej opartej na wykorzystaniu techniki ekstrakcji do fazy stałej (na etapie izolacji i wzbogacania analitów) do oznaczania śladowych ilości zanieczyszczeń organicznych w wodzie specjalnej czystości używanej do celów farmaceutycznych.Próbka badanej wody jest przepuszczana przez złoże sorbenta, które jest osuszane za pomocą strumienia oczyszczonego powietrza, przed etapem termicznej...
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Comparison of the main bioactive compounds and antioxidants in garlic and white and red onion after treatment protocols
PublicationPolski czosnek, biała i czerwona cebula była blanszowana, gotowana, smażona i poddawana działaniom promieniowania mikrofalowego. Następnie były w nich oznaczane m.in. takie związki jak polifenole, flawonoidy, kwas ascorbinowy i aktywne antyoksydanty. Udowodniono, że blanszowanie, smażenie i poddawanie działaniu promieniowania mikrofalowego nie wpływa znacząco na zmiejszenie zawartości badanych związków w czosnku i cebuli. Wyznaczono...
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Combined spline wavelet decomposition for 3d seafloor imaging from multibeam sonar echoes
PublicationThe paper proposes combined spline-wavelet approach to the raw echoes seaflor imaging from Multibeam Sonar System (MBSS) records. Wavelet representation is closely related to image representation, due to its unique approximations properties. Splines have the best approximation properties among all known wavelets of a given order, so they are best suited for approximating of smooth seafloor surface. Additionaly, wavelet bases have...
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Współczesne problemy i i kierunki rozwoju elastycznych systemów produkcyjnych
PublicationPrzedstawione opracowanie monograficzne poświęcone jest współczesnej problematyce elastycznych systemów produkcyjnych, a w szczególności ich zagadnieniom sterowania i wytwarzania. Zawarto w nim także charakterystykę najbardziej zaawansowanych technologii informatycznych; dokonano klasyfikacji ich metod oraz podstawowych problemów metodologicznych ich projektowania w zakresie planowania, sterowania i wytwarzania. Praca obejmuje...
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Green Chemistry - current and future issues
PublicationW pracy przedstawiono 12 zasad Zielonej Chemii oraz wybrane przykłady stosowania zasad w życiu codziennym, przemyśle, laboratoriach i edukacji. Pokrótce opisano historię Zielonej Chemii oraz przyszłe wyzwania. ZCH dotyczy nowego podejścia do zagadnienia syntezy, przeróbki i wykorzystania związków chemicznych, związanego ze zmniejszeniem zagrożenia dla zdrowia i środowiska. Istnieje wiele publikacji opisujących metodyki analityczne...
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The new measures of the population ageing
PublicationZestarzenie się populacji mierzy sie zwykle frakcją osób starszych. Miara ta nie uwzględnia rozkładu wieku wśród osób starszych. W pracy przedstawiane są nowe miary zestarzenia się populacji, których ideę zaczerpnięto z ekonomiki ubóstwa: absolutna luka wiekowa AG, relatywna luka wiekowa RAG, syntetyczna miara HRAG=HCR. RAG oraz syntetyczna miara P2. Te nowe miary testowo analizując proces zestarzenia się w 4 krajach europejskich...
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Exploratory analysis - extraction of dispersed information
PublicationWiększość analityków środowiska uważa, że ich praca kończy sie z chwilą uzyskania wiarygodnych danych o zawartości w próbce poszukiwanego analitu. Jest to jednak przestarzały punkt widzenia. W typowej próbce środowiskowej oznacza się zwykle kilkanaście lub więcej analitów. ''Ręczna'' analiza wyników uzyskanych dla zestawu takich próbek jest praktycznie niemożliwa. Ponadto w takich wielowymiarowych danych najbardziej użyteczne informacje...
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Footbridges. Dynamic Design – Selected Problems
PublicationModern footbridges create challenge in esthetic and structural design. Breaking the proven canons is a recipe for architectural success. However esthetic form has to be also a functional pedestrian bridge. Therefore a good FEM modeling is a key element in engineering part of design. The paper presents selected problems related to the modeling of the dynamic construction of footbridges. Several basic dynamic problems concerning...
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An analysis of the characteristics of Indonesian industrial sectors: 2005-2010
PublicationThe purpose of the current study is to analyze the characteristics of Indonesian industrial sectors from 2005 through 2010. The study employs the analysis instruments from the Input-Output (IO) analysis, namely the indices of the power of dispersion, and the sensitivity of dispersion. For 2005 and 2010, the study focuses on nine and seventeen industries, respectively. The results show that industry 3, manufacturing, placed the...
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An analysis of the characteristics of Indonesian industrial sectors: 2005-2010
PublicationThe purpose of the current study is to analyze the characteristics of Indonesian industrial sectors from 2005 through 2010. The study employs the analysis instruments from the Input-Output (IO) analysis, namely the indices of the power of dispersion, and the sensitivity of dispersion. For 2005 and 2010, the study focuses on nine and seventeen industries, respectively. The results show that industry 3, manufacturing, placed the...
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Weather Routing System Architecture Using Onboard Data Collection and Route Optimisation
PublicationThis paper describes the architecture of a weather routing system consisting of two key elements: onboard monitoring and route optimiser sub-systems. The former is responsible for collecting various onboard measurements, such as current ship position or ship motion variables. These data, when gathered and processed, are then used for fine-tuning a ship model. The model, together with weather forecasts, is utilised by a multi-objective...
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Method of Monitoring of the Grinding Process with Lapping Kinematics Using Audible Sound Analysis
PublicationUtilising microphones as audible sound sensors for monitoring a single-side grinding process with lapping kinematics is presented in the paper. The audible sound generated during grinding depended on the cutting properties of electroplated tools with D107 diamond grains and different thicknesses of the nickel bond. The tool wear affected the obtained technological effects such as material removal rate and the surface roughness...
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Action Plan “Women”
PublicationEmployees of a company are not the first alternative coming into one’s mind when searching suitable successor for the business. Those belonging to the company’s management group are in many cases asked for their interest in being a successor, but the lower level an employee is in the hierarchy, the less probably he/she is inquired of his/her interest in becoming a successor. The contemporary entrepreneur may have had conflicts...
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Single-phase power electronics transformer with active functions for smart grid
PublicationThis paper presents the control of one cell of a modular single-phase power electronics transformer with active functions for meeting the smart grid concept. In this way, the converter could be used not only as a conventional transformer but also for grid such as reactive power, harmonic elimination and energy storage. The topology of the cell is composed by a bidirectional converter with three stages: a half bridge in the input...
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Flood Classification in a Natural Wetland for Early Spring Conditions Using Various Polarimetric SAR Methods
PublicationAbstract--- One of the major limitations of remote sensing flood detection is the presence of vegetation. Our study focuses on a flood classification using Radarsat-2 Quad-Pol data in a natural floodplain during leafless, dry vegetation (early spring) state. We conducted a supervised classification of a data set composed of nine polarimetric decompositions and Shannon entropy followed by the predictors' importance estimation to...
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Selective monitoring of noise emitted by vehicles involved in road traffic
PublicationAn acoustic intensity probe was developed measures the sound intensity in three orthogonal directions, making possible to calculate the azimuth and elevation angles, describing the sound source position. The acoustic sensor is made in the form of a cube with a side of 10 mm, on the inner surfaces of which the digital MEMS microphones are mounted. The algorithm works in two stages. The first stage is based on the analysis of sound...
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Mapping of the Covid-19 Vaccine Uptake Determinants From Mining Twitter Data
PublicationOpinion polls on vaccine uptake clearly show that Covid-19 vaccine hesitancy is increasing worldwide. Thus, reaching herd immunity not only depends on the efficacy of the vaccine itself, but also on overcoming this hesitancy of uptake in the population. In this study, we revealed the determinants regarding vaccination directly from people’s opinions on Twitter, based on the framework of the 6As taxonomy. Covid-19 vaccine acceptance...
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On-line measurement of wood surface smoothness
PublicationThe latest progress in the field of optics and microelectronics resulted in development of new generation vision systems capable of scanning surface topography with very high sampling frequencies. The blue color of illuminating light as well as novel systems for controlling ultra-thin laser line thickness allows measurement of the porous surface of wood with a triangulation method. Three alternative sensors were tested here in...
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State tax policy and reform tools as a risk of running a business. Case study based on Polski Ład – Polish tax reform
PublicationThe aim of the article is to describe and present the Polish tax reform introduced at the beginning of 2022. Tax changes introduced in Poland had a strong impact on the risk of running a business in Poland because in their assumption they directly changed the rules of running a business. Due to the pace of the introduced changes, as well as the scope of the reform, the new tax law was subject to numerous criticisms of taxpayers...
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Optimal placement of IMU sensor for the detection of children activity
PublicationIn this paper an investigation to determine the optimal placement of IMU sensors for the purpose of children characteristic activity detection is presented. The article compares four different placement of two IMU sensors on human body. Ten healthy volunteers participated within the study. Data were collected firstly from two wireless 9-axial IMU sensors placed at the left and right wrists, then sensors were placed at lower back...
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System for characterisation and multidimensional imaging of seafloor using multibeam sonar data
PublicationMultibeam sonars are widely used in applications like high resolution bathymetry measurements, underwater object detection and imaging, etc. Also, they are the promising tool in seafloor characterisation and classification, having several advantages over conventional single beam echosounders. The proposed approach to seafloor classification relies on the combined use of three different techniques. In each of them, a set of descriptors...
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Evaluation of the prediction ability of air pollutants based on the electronic nose responses
PublicationElectronic noses are able to perform on-line measurements of the toxic volatile compounds in air. Due to their low cost and compact size they can be placed in the areas exposed to pollution, outside the laboratory. Those advantages, on the other side, force the need for development of the reliable sensors data analysis procedures. One of the most important issues connected with electronic noses is the lack of stability of the gas...
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Experiment with small objects floating under water in the harbor security aspect.
PublicationObservation of the underwater area is the element of general trend which primary purpose is to protect and enhance the safety of the selected region. The aim of the paper is to present the acoustic characteristics of typical objects floating on the surface or under the water, which constitute some knowledge on how to detect these objects. Create a catalog of acoustic signatures and acoustic images of objects mostly floating under...
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Reurbanizacja wielkich osiedli mieszkaniowych w kontekście kształtowania wizerunku polskiej metropolii
PublicationZagadnienie transformacji wielkich osiedli mieszkaniowych to w warunkach polskich proces reurbanizacji struktury ogólnomiejskiej. Ośrodki polskie pretendujące do roli współczesnych metropolii stawić muszą czoła kwestii blokowisk stanowiących zasadniczą część swego zasobu mieszkaniowego. Czynniki wpływające na proces transformacji mają charakter ponadlokalny - rynek mieszkaniowy, rynek pracy, trendy kulturowe. Wielkie osiedla mieszkaniowe...
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Aluminium in glacial meltwater demonstrates an association with nutrient export (Werenskiöldbreen, Svalbard)
PublicationThe aluminium (Al) cycle in glacierised basins has not received a great deal of attention in studies of biogeochemical cycles. As Almay be toxic for biota, it is important to investigate the processes leading to its release into the environment. It has not yet been ascertained whether filterable Al (passing through a pore size of 0.45 m) is incorporated into biogeochemical cycles in glacierised basins. Our study aims to determine...
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Application and modelling of Shape-Memory Alloys for structural vibration control: State-of-the-art review
PublicationOne of the most essential components of structural design for civil engineers is to build a system that is resistant to environmental conditions such as harsh chemical environments, and catastrophic disasters like earthquakes and hurricanes. Under these circumstances and disturbances, conventional building materials such as steel and concrete may demonstrate inadequate performance in the form of corrosion, deterioration, oxidizing,...
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Determination of nine high-intensity sweeteners in various foods by high-performance liquid chromatography with mass spectrometric detection
PublicationAn analytical procedure involving solid-phase extraction (SPE) and high-performance liquid chromatography-mass spectrometry has been developed for the determination of nine high-intensity sweeteners authorised in the EU; acesulfame-K (ACS-K), aspartame (ASP), alitame (ALI), cyclamate (CYC), dulcin (DUL), neohesperidin dihydrochalcone (NHDC), neotame (NEO), saccharin (SAC) and sucralose (SCL) in a variety of food samples (i.e. beverages,...
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A MEASUREMENT SYSTEM FOR MONITORING CARDIOVASCULAR EVENTS IN SYNCOPE PATIENTS
PublicationSyncope phenomena is an abrupt and transient loss of consciousness leading to interruption of awareness of one’s surroundings and falls with risk of injury. Syncope is often followed by complete and usually rapid spontaneous recovery. It is said that half of all individuals experience syncopal event at least once during their life. The condition can occur at any age and happens in people with and without other medical problems....
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Sandwich Biobattery with Enzymatic Cathode and Zinc Anode Integrated with Sensor
PublicationCarbon paper covered with side-naphthylated multi walled carbon nanotubes was used as the conducting support for the construction of a biocathode in a hybrid biofuel cell. Laccase Carrena unicolor enzyme was employed as the catalyst for the 4e reduction of oxygen and a zinc disc covered with hopeite was used as the anode. Derivatized carbon nanotubes increase the working surface of the electrode and provide direct contact with...
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Towards β-selectivity in functional estrogen receptor antagonists
PublicationBased on the benzo[b]naphtho[1,2-d]furan and benzo[b]naphtho[1,2-d]thiophene frameworks, a series of ligands with different basic side chains (BSCs) has been synthesized and pharmacologically evaluated. Also, their binding modes have been modelled using docking techniques. It was found that the introduction of a BSC in these systems brings about a decrease of affinity for both estrogen receptors α and β in an in vitro competitive...
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A Self-Equalized Waveguide Filter With Frequency-Dependent (Resonant) Couplings
PublicationThis letter presents a design of a fifth-order linear phase filter with frequency-dependent couplings. The filter is composed of a triplet that is directly coupled to two resonators at the input and output. To provide group delay flattening a cross-coupling in the trisection has a strongly dispersive character with a negative slope parameter. To achieve this, an E-plane stub with a septum was used. To further improve the filter...
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Analysis of drinking water
PublicationOpisano źródła organicznych i nieorganicznych zanieczyszczeń wody do picia w tym: lotnych związków chlorowcoorganicznych, pestycydów, wielopierścieniowych węglowodorów aromatycznych, polichlorowanych bifenyli, fenoli, kwasów chlorooctowych, aldehydów, ketonów itp. a także metody ich oznaczania. Przedstawiono schemat technik izolacji i oznaczania końcowego oraz schemat metod wykorzystujących analizę fazy nadpowierzchniowej. Opisano...
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Synthesis of amides under microwave irradiation
PublicationAmides belong to the most important carboxylic acid derivatives. They are constituents of natural compounds like peptides and proteins. They found applications in many branches of science and industry, especially in pharmaceutical and polymer science. Conventional procedures for amide preparation involve reaction between amine and carboxylic acid or their more active derivatives such as acid chlorides, acid anhydrides or esters....
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Geographic information system for remote integration of diverse under-water acoustic sensor data
PublicationMaritime and port areas throughout the world are exposed to many different hazards, like pollution, terrorism and natural disasters. Early detection, identification and preparation of appropriateesponse strategies is especially important in the case of semi-enclosed basins like the Baltic Sea, mainly due to the marine ecosystems' continuous absorption of pollutants including oil, heavy metals and chemicals. Many of those agents...
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Amphotericin B and Its New Derivatives - Mode of Action
PublicationAmphotericin B (AmB) is a well known antifungal and antiprotozoal antibiotic used in the clinic for several decades. Clinicalapplications of AmB, however, are limited by its nephrotoxicity and many other acute side effects which are not acceptable by patientswhen their life is not threaten. In order to improve the therapeutic index of this drug, lipid formulations have been introduced and manyefforts have been made to obtain less...
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Self-organizing maps classification of epidemiological data and toenail selenium content monitored on cancer and healthy patients from Poland
PublicationW pracy przedstawiono wyniki wielowymiarowej analizy danych pomiarowych (przy wykorzystaniu techniki samoorganizującej sie mapy (SOM))nad oszacowaniem zawartości selenu w próbkach paznokci pobranych od mieszkańców Województwa Pomorskiego ((w tym od grupy osób zdrowych i ze zdiagnozowaną chorobą nowotworową) i Lubuskiego. W wyniku przeprowadzonej analizy uzyskano podział uczestników ze zdiagnozowanym nowotworem na trzy różne grupy:1...
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Daily dietary selenium intake of the Pomeranian District inhabitants
PublicationSe, uznawany za jeden z najważniejszych mikroelementów, znalazł sie w centrum zainteresowania naukowców z wielu dziedzin. Niedostatecznalub nadmierna zawartość Se w dziennej diecie może prowadzić do niekorzystnych zmian w funkcjonowaniu organizmu czlowieka, a więc aby temu zapobiec powinniśmy suplementować ten pierwiastek, bądź ograniczać jego wprowadzanie do organizmu. W związku z tym dzienna dawka selenu spożywana przez człowieka...
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Pedestrian on footbridges, vertical loads and response
PublicationThe paper is a synthesis of the experimental and theoretical investigations on dynamics of pedestrian bridges under vertical load The subject is divided into four issues.1) The pedestrian as a vertical dynamic load on footbridges, theoretic load function for walking and crouching.2) Crowd walking on the footbridge - pedestrian flow.3) Vertical lock-in effect.4) Response of the footbridge - numeric and side test results, -...
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Zasady działania i rola biura zarządzania programem w realizacji projektów inwestycyjnych Euro 2012
PublicationProjekty inwestycyjne realizowane w Polsce w ramach przygotowań do Euro 2012 można, w celu lepszego nimi zarządzania, w zestawiać w pewne grupy, tj. programy oraz teczki projektów i zarządzać nimi całosciowo w sposób zintegrowany. W niniejszym opracowaniu przedstawiono propozycję rozwiązań organizacyjnych, polegających na tworzeniu BIUR zarządzania programem EURO 2012 w miastach- gospodarzach, zajmujacych sie zarządzaniem podprogramami...
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Fatigue resistance investigation of the mb46 plain bearings under conditions of dynamic loadings
PublicationOdporność materiału łożyskowego MB46 na pęknięcia zmęczeniowe badano na stanowisku SMOK, w którym generowane jest zmienne jednokierunkowe obciążenie badanego łożyska. Materiał łożyskowy MB46 składa sie z warstwy brązu CuPb22Sn 3 spiekanego na taśmie stalowej, stanowiącej podłoże. Na warstwę brązu nałożona jest galwanicznie cienka warstwa stopu SnCu6 stanowiąca powłokę. Każde z badanych łożysk poddawane było 20-godzinnemu testowi...