Filtry
wszystkich: 1685
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Wyniki wyszukiwania dla: BLOOD VESSEL TUMORS
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Designing a ship course controller by applying the adaptivebackstepping method
PublikacjaThe article discusses the problem of designing a proper and efficient adaptive course-keeping control system for a seagoingship based on the adaptive backstepping method. The proposed controller in the design stage takes into account thedynamic properties of the steering gear and the full nonlinear static maneuvering characteristic. The adjustable parametersof the achieved nonlinear control structure were tuned up by using the...
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Simulation studies into quayside transport and storage yard operations in container terminals
PublikacjaThe focus of the paper is on quayside transport and storage yard operations in the sea container terminals. Developed algorithms for solving the issues of load handling and storage space allocation have been applied in the frame of adopted simulation model. The criteria chosen for decision making involved the total makespan of vessel unloading and the utilisation levels of the transportation trucks. Recommendations for unloading...
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Dynamic Positioning System with Vectorial Backstepping Controller
PublikacjaThe problem of synthesis a dynamic positioning system for low frequency model of surface vessel was considered in this paper. The recursive vectorial backstepping control design was used to keep a fixed position and heading in presence of wave disturbances. The passive observer was introduced to smooth the measurements and to estimate the velocities needed for the control algorithm. Some parameters of observer were optimized off-line...
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Adaptive dynamic control allocation for over-actuated dynamic positioning system based on backstepping method in case of thruster faults
PublikacjaThe objective of the research considered in this paper is dynamic positioning of a nonlinear over-actuated marine vessel in the presence of limited information about thruster forces. First, the adaptive backstepping method is used to estimate the input matrix which will compensate partial loss of actuator effectiveness in the presence of actuator dynamics. Then, the adaptive commanded virtual forces and moment are allocated into...
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Phosphoroorganic Metal Complexes in Therapeutics
PublikacjaThe present mini-review highlights recent developments on antitumor activity of metal-based therapeutics which have been a subject of researches for the last few decades. In 1965, Rosenberg found that during an electrolysis on platinum electrodes a complex of Pt is generated which inhibited to a great extent a binary fission in Escherichia coli bacteria. This discovery started a new chapter in medicinal chemistry and the interesting...
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Pial artery and subarachnoid width response to apnoea in normal humans
PublikacjaBackground: Little is known about intracranial pressure (ICP)-cerebral haemodynamic interplay during repetitive apnoea. A recently developed method based on near-infrared transillumination/backscattering sounding (NIR-T/BSS) noninvasively measures changes in pial artery pulsation (cc-TQ) as well as subarachnoid width (sas-TQ) in humans. Method: We tested the complex response of the pial artery and subarachnoid width to apnoea...
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Antibacterial Activity and Cytocompatibility of Bone Cement Enriched with Antibiotic, Nanosilver, and Nanocopper for Bone Regeneration
PublikacjaBacterial infections due to bone replacement surgeries require modifications of bone cement with antibacterial components. This study aimed to investigate whether the incorporation of gentamicin or nanometals into bone cement may reduce and to what extent bacterial growth without the loss of overall cytocompatibility and adverse effects in vitro. The bone cement Cemex was used as the base material, modified either with gentamicin...
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Proposal of New Tracer Concentration Model in Lung PCT Study Comparison with Commonly Used Gamma-variate Model
PublikacjaPerfusion computed tomography (pCT) is one of the methods that enable non-invasive imaging of the hemodynamics of organs and tissues. On the basis of pCT measurements, perfusion parameters such as blood flow (BF), blood volume (BV), mean transit time (MTT) and permeability surface (PS) are calculated and then used for quantitative evaluation of the tissue condition. To calculate perfusion parameters it is necessary to approximate...
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Semantic segmentation training using imperfect annotations and loss masking
PublikacjaOne of the most significant factors affecting supervised neural network training is the precision of the annotations. Also, in a case of expert group, the problem of inconsistent data annotations is an integral part of real-world supervised learning processes, well-known to researchers. One practical example is a weak ground truth delineation for medical image segmentation. In this paper, we have developed a new method of accurate...
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Cytokine IL6, but not IL-1β, TNF-α and NF-κB is increased in paediatric cancer patients
PublikacjaCytokines are responsible for maintaining homeostasis as cell growth, differentiation, migration and apoptosis mediators. They play a pivotal role in immune responses to inflammatory reactions. In oncological diseases, the cross-talk between cells of the immunological system and cells of the tumour microenvironment is led by cytokines. Also, the overproduction of cytokines may change the tumour microenvironment and stimulate tumour...
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Automatic Identification System (AIS) Dynamic Data Integrity Monitoring and Trajectory Tracking Based on the Simultaneous Localization and Mapping (SLAM) Process Model
PublikacjaTo enhance the safety of marine navigation, one needs to consider the involvement of the automatic identification system (AIS), an existing system designed for ship-to-ship and shipto- shore communication. Previous research on the quality of AIS parameters revealed problems that the system experiences with sensor data exchange. In coastal areas, littoral AIS does not meet the expectations of operational continuity and system availability,...
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Review of Selected Methods for Prediction of Added Resistance in Following Waves
PublikacjaThe added resistance in waves is a mean value of non-linear, second order reaction of a ship to incoming waves. In the beginning of the 20th century, the experimental methods for investigation of ship hydrodynamics at model scale were developed. They allowed the evaluation of added resistance by measurements in irregular waves (directly) or by measurements in regular waves (in-direct method). The main goal was to find more precise...
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Wavelet transform analysis to assess oscillations in pial artery pulsation at the human cardiac frequency
PublikacjaPial artery adjustments to changes in blood pressure (BP)may last only seconds in humans. Using a novelmethod called near-infrared transillumination backscattering sounding (NIR-T/BSS) that allows for the non-invasive measurement of pial artery pulsation (cc-TQ) in humans, we aimed to assess the relationship between spontaneous oscillations in BP and cc-TQ at frequencies between 0.5 Hz and 5 Hz. We hypothesized that analysis of...
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Trim Optimisation - Theory and Practice
PublikacjaForce Technology has been working intensively with trim optimisation tests for almost last 10 years. Focus has primarily been put on the possible power savings and exhaust gases reduction. This paper describes the trim optimisation process for a large cargo vessel. The physics behind changed propulsive power is described and the analyses in order to elaborate the optimum trimmed conditions are presented. Different methods for prediction...
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Data fusion of GPS sensors using Particle Kalman Filter for ship dynamic positioning system
PublikacjaDepending on standards and class, dynamically positioned ships make use of different numbers of redundant sensors to determine current ship position. The paper presents a multi-sensor data fusion algorithm for the dynamic positioning system which allows it to record the proper signal from a number of sensors (GPS receivers). In the research, the Particle Kalman Filter with data fusion was used to estimate the position of the vessel....
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Shipping Safety Management on Polish Inland Waterways
PublikacjaOver the past years, the role of inland waterway transport has increased compared to other modes of transport. The increasing intensity of the inland vessel traffic significantly affects the safety of navigation. The article analyses the main causes of accidents and incidents that occurred on the Odra Waterway and Lower Vistula. The authors have classified those accidents and suggested possible directions for the development of...
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Prototype of an opto-capacitive probe for non-invasive sensing cerebrospinal fluid circulation
PublikacjaIn brain studies, the function of the cerebrospinal fluid (CSF) awakes growing interest, particularly related to studies of the glymphatic system in the brain, which is connected with the complex system of lymphatic vessels responsible for cleaning the tissues. The CSF is a clear, colourless liquid including water (H2O) approximately with a concentration of 99 %. In addition, it contains electrolytes, amino acids, glucose, and...
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Nitric Oxide-Dependent Pathways as Critical Factors in the Consequences and Recovery after Brain Ischemic Hypoxia
PublikacjaBrain ischemia is one of the leading causes of disability and mortality worldwide. Nitric oxide (NO), a molecule that is involved in the regulation of proper blood flow, vasodilation, neuronal and glial activity constitutes the crucial factor that contributes to the development of pathological changes after stroke. One of the early consequences of a sudden interruption in the cerebral blood flow is the massive production of reactive...
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Antitumor DNA-Damaging C-1748 is a New Inhibitor of Autophagy that Triggers Apoptosis in Human Pancreatic Cancer Cell Lines
PublikacjaDespite the enormous progress that has been made over the past decades in diagnosis, treatment and prevention of many types of tumors, survival rates in pancreatic cancer still remain poor. Pancreatic cancer is one of the most malignant and chemoresistant tumors and the profound mechanism supporting these phenomena is the constitutively activated prosurvival autophagy. The antitumor 1-nitroacridine derivative C-1748 belongs to...
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Opioid Growth Factor and its Derivatives as Potential Non-toxic Multifunctional Anticancer and Analgesic Compounds
PublikacjaIn this paper, we review the structure-activity relationship of OGF and its analogues. We highlight also OGF derivatives with analgesic, immunomodulatory activity and the ability to penetrate the blood-brain barrier and may be used as safe agents enhancing chemotherapy efficacy and improving quality of life in cancer patients. The reviewed papers indicate that Met-enkephalin and its analogues are interesting candidates for the...
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A scale with ECG measurements capability for home cardiac monitoring
PublikacjaPresented device -a scale developed for enabling extra measurements, in addition to body weight and composition, the electrical activity of the heart (electrocardiogram - ECG) and the level of oxygen saturation in the blood SaO2. Electrical activity is recorded in the form of six leads, socalled - limb leads. The device allows measurement of all standard limb leads and without the need for additional procedures. ECG, although the...
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Influence of preprocessing techniques on pulse pressure velocity determination
PublikacjaPulse Wave Velocity (PWV) is measured and utilized in many clinical applications. Recently, a wide research has been led to develop a cuff-less and continuous blood pressure method basing on PWV. However, in this application a decision on choosing an appropriate fiducial point of pulse wave (PW) waveform is necessary and substantial. It would allow to measure time parameters necessary to determine PWV. An influence of sampling...
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MONTE CARLO MODELING OF OPTICAL SENSOR FOR POST-OPERATIVE FREE FLAP MONITORING
PublikacjaAfter a preliminary study of the currently employed methods in vitality monitoring of the tissue flaps (TRAM, DIEP, SIEA), a usefulness of optical techniques is discussed. It seems that one of the most promising in monitoring tissue flaps blood flow is a near infrared spectrometry (NIRS). However, a special design of a measurement sensor has to be developed. First, basing on the literature study an optical “window” is characterized....
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Post-match recovery profile of leukocyte cell subsets among professional soccer players
PublikacjaThis study assessed the impact of cumulative match time on the distribution of CD45+ cell subtests in the capillary blood of professional soccer players. Twenty-two males (aged 18–30 years) took part in the 36-week study. Participants playing up to 540 in cumulative match time and less than 30 min in each single match during the observation period formed the control group. White blood cell (WBC) phenotyping and creatine kinase...
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Effect of Maximal Apnoea Easy-Going and Struggle Phases on Subarachnoid Width and Pial Artery Pulsation in Elite Breath-Hold Divers
PublikacjaPurpose: The aim of the study was to assess changes in subarachnoid space width (sas-TQ), the marker of intracranial pressure (ICP), pial artery pulsation (cc-TQ) and cardiac contribution to blood pressure (BP), cerebral blood flow velocity (CBFV) and cc-TQ oscillations throughout the maximal breath hold in elite apnoea divers. Non-invasive assessment of sas-TQ and cc-TQ became possible due to recently developed method based on...
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Molecular detection of Candida krusei
PublikacjaThe species identification of fungi belonging to genus Candida is an important issue as this genus becomes the emerging problem of nosocomial infections. As Candida krusei presents intrinsicresistance to the fluconazole that is the drug of the first choice in case of invasive candidiasis the PCR identifying the DNA of C. krusei was elaborated. The analytical sensitivity of the assay on spiked blood samples was estimated at 3-5...
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Long-Term Measurement of Physiological Parameters – Child Dataset
PublikacjaThe dataset titled “Long-term measurement of physiological parameters – child is one dataset” of the bigger series named Long-term measurement of physiological parameters. The dataset contains physiological parameter measurements such as skin temperature and resistance, blood pulse, as well as the stress detection marker, which can have a value of 0 when there is no stress detected or 1 when stress appeared. Additionally, the dataset...
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Maintenance therapy with everolimus for subependymal giant cell astrocytoma in patients with tuberous sclerosis (the EMINENTS study)
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Endometrial nitric oxide production and nitric oxide synthases in the equine endometrium: Relationship with microvascular density during the estrus cycle
PublikacjaNitric oxide (NO) plays an important role in angiogenesis and in the regulation of the blood flow. This study was carried out to investigate (i) the effects of endogenous estrogens and progestins and exogenous progesterone (P(4)) (5 ng/ml or 1 microg/ml) or estradiol 17beta (E(2)beta) (50 pg/ml or 1 microg/ml) on in vitro endometrial NO synthesis; (ii) the presence of different isoforms of NO synthase;...
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The imidazoacridinone C-1311 induces p53-dependent senescence or p53-independent apoptosis and sensitizes cancer cells to radiation
PublikacjaC-1311 is a small molecule, which has shown promise in a number of preclinical and clinical studies. However, the biological response to C-1311 exposure is complicated and has been reported to involve a number of cell fates. Here, we investigated the molecular signaling which determines the response to C-1311 in both cancer and non-cancer cell lines. For the first time we demonstrate that the tumor suppressor, p53 plays a key role...
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Combined Close Range Photogrammetry and Terrestrial Laser Scanning for Ship Hull Modelling
PublikacjaThe paper addresses the fields of combined close-range photogrammetry and terrestrial laser scanning in the light of ship modelling. The authors pointed out precision and measurement accuracy due to their possible complex application for ship hulls inventories. Due to prescribed vitality of every ship structure, it is crucial to prepare documentation to support the vessel processes. The presented methods are directed, combined...
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Path planning algorithm for ship collisions avoidance in environment with changing strategy of dynamic obstacles
PublikacjaIn this paper a path planning algorithm for the ship collision avoidance is presented. Tested algorithm is used to determine close to optimal ship paths taking into account changing strategy of dynamic obstacles. For this purpose a path planning problem is defined. A specific structure of the individual path and fitness function is presented. Principle of operation of evolutionary algorithm and based on it dedicated application...
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The Use of Unmanned Surface Vessels in Bathymetric Measurements of Waterbodies with Highly Dynamic Seafloor Relief
PublikacjaThe early 21st century is a time when unmanned surface vessels (USV) are used in various measurement applications. Modern autonomous and unmanned vessels are increasingly often used in bathymetric measurements whose aim is to measure the seafloor with the sufficient positioning accuracy. Therefore, the use of USVs in hydrography can be seen as the beginning of a new era in this regard. This paper presents bathymetric measurements...
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Synthesis and antiproliferative activity of new mycophenolic acid conjugates with adenosine derivatives
PublikacjaNew conjugates of mycophenolic acid (MPA) and adenosine derivatives were synthesized and assessed as potential immunosuppressants on Jurkat cell line and peripheral blood mononuclear cells (PBMC) from healthy donors. As compared to MPA, all compounds were found to be more active against Jurkat cell line. The antiproliferative activities were compared with MPA and adenosine, in both 2′,3′-O-isopropylidene protected and free hydroxyl...
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Modelling of Diffusing Capacity Measurement Results in Lung Microangiopathy Patients. A novel Diagnostic Suppport
PublikacjaLung microangiopathy is a little known negative influence of diabetes mellitus on the functioning of the lungs. The aim of this study is to design a supportive method for diagnosing lung microangiopathy. This will be based on routinely performed pulmonary measurements as well as on investigation process modelling and data processing. A model of the diffusion of oxygen from the alveoli to the blood has been described with a set...
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Synthesis and biological activity of mycophenolic acid-amino acid derivatives
PublikacjaIn search of new immunosuppressants, mycophenolic acid (MPA) was coupled with amino acid methyl esters followed by hydrolysis to analogs bearing free carboxylic groups. The obtained compunds were tested in vitro as growth inhibitors of lymphoid cell line (Jurkat) and human peripheral blood mononuclear cells (PBMC) from healthy donors. According to obtained results recovering of free carboxylic group increased their activity. Additionally,...
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Determination of thiocyanate (biomarkers of ETS) and other inorganic ions in human nasal discharge samples using ion chromatography
PublikacjaEnvironmental tobacco smoke (ETS) is a mixture of air and tobacco smoke containing more than 4000 chemical substances. In view of the health risks of many of these substances, studies are needed to determine biomarkers of exposure to ETS constituents in people who actively or passively are exposed to the toxic compounds. The methodologies for determining most biomarkers from saliva, urine and blood samples are known, but methods...
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Ship’s de-perming process using coils lying on seabed
PublikacjaA ship built from ferromagnetic steel disturbs the uniformity of the Earth’s magnetic field. Changes of ship’s signature are due to the magneto-mechanical interaction of the hull with the Earth’s magnetic field. The ship’s magnetic field can be detected by a magnetic naval mine. For this reason, the vessel has to be demagnetized. There are several methods of ship’s de-perming. The results of experimental and computer simulations...
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RAMAN DIAGNOSTICS OF CVD DIAMOND GROWTH
PublikacjaDevelopment of Raman spectroscopic system for diagnostics of growth of diamond and BDD (Boron- Doped-Diamond) thin films during μPA CVD (Microwave Plasma Assisted Chemical Vapour Deposition) process is described. Raman studies of such films were carried out as in-situ monitoring of film deposition as ex-situ measurements conducted for a sample outside the reaction vessel after manufacturing process. Modular system for the in-situ...
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VARIANT DESIGNING IN the PRELIMINARY SMALL SHIP DESIGN PROCESS
PublikacjaShip designing is a complex process, as the ship itself is a complex, technical multi-level object which operates in the air/water boundary environment and is exposed to the action of many different external and internal factors resulting from the adopted technical solutions, type of operation, and environmental conditions. A traditional ship design process consists of a series of subsequent multistage iterations, which gradually...
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The hydrodynamic pressure field of the ship Zodiak, measurements and calculations
PublikacjaThe article presents the results of measurements of the slowly changing hydrodynamic pressure field HPF generated by the movement of the ship, Zodiak, in the Bay of Gdansk. The measurement results have been obtained in the framework of the program of the work in Siramis, under the auspices of the European Defence Administration of the EU, by the research team of the Naval Academy in Gdynia. The measurement results were compared with...
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Classification of Sea Going Vessels Properties Using SAR Satellite Images
PublikacjaThe aim of the project was to analyze the possibility of using machine learning and computer vision to identify (indicate the location) of all sea-going vessels located in the selected area of the open sea and to classify the main attributes of the vessel. The key elements of the project were to download data from the Sentinel-1 satellite [1], download data on the sea vessels [2], then automatically tag data and develop a detection...
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Modeling of Accidental Bunker Oil Spills as a Result of Ship's Bunker Tanks Rupture - a Case Study
PublikacjaAIS (Automatic Identification System) data analysis is used to define ship domain for grounding scenarios. The domain has been divided into two areas as inner and outer domains. Inner domain has clear border, which is based on ship dynamic characteristics. Violation of inner domain makes the grounding accident unavoidable. Outer domain area is defined with AIS data analyzing. Outer domain shows the situation of own ship in compare...
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Diesel electric a new trend on the ship propulsion
PublikacjaW artykule przedstawiono rozwój napędu "diesel elektrycznego" oraz argumentację zastosowania tego napędu na różnych typach statków. Referat zawiera również rozwiązania układu transmisji mocy oraz sprawność, jaka cechuje napęd elektryczny. W artykule zawarto również zalety tego napędu, oraz zwrócono uwagę na nowe koncepcje i rozwiązania korzystne dla wytwarzania i transmisji mocy w napędzie elektrycznym.This article presents development...
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The Accuracy of a Marine Satellite Compass under Terrestrial Urban Conditions
PublikacjaWhen used at sea, satellite compasses are capable of determining the course of a sailing vessel with high accuracy. It is dicult to verify the accuracy declared by the device manufacturer under such conditions, as it is dicult to define a reliable reference. This study analyses the accuracy of the satellite compass in an urban setting, with the satellite signal being obscured to various extents. It is an important point in the...
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Common methods for the chiral determination of amphetamine and related compounds I. Gas, liquid and thin-layer chromatography
PublikacjaThis article reviews the most common, useful methods for the chiral determination of amphetamine (AM) and AM-deriveddesigner drugs in different of matrix, including blood, hair, urine, medicaments or standard solutions, taking into considerationarticles published in the past 15 years. We consider chromatographic methods (e.g., gas, liquid, high-performance liquid, and thinlayer). We describe several types of chiral derivatization...
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New PCR test for detection of Candida glabrata based on the molecular target chosen by the RAPD technique
PublikacjaRapid, reliable diagnosis is a necessary condition for the successful treatment of infections. Such diagnostic assays are continually being developed. #e paper presents a method for selecting the molecular target for PCR-based diagnostics based on the comparison of RAPD patterns. A sequence encoding Candida glabrata CBS138 hypothetical protein was selected. The limit of detection for PCR and real-time PCR reactions with DNA extracted...
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CARDIOVASCULAR RISK FACTORS AMONG POLISH EMPLOYEES OF UNIFORMED SERVICES
PublikacjaObjectives: Employees of uniformed services (EoUS) were screened for cardiovascular risk factors. Material and Methods: A total of 1138 EoUS (age M±SD 49.9±6.0 years) and 263 controls (age M±SD 54.4±9.7 years) under the care of the cardiology clinic in Gdańsk, Poland,were included in the study. Medical history and blood samples were collected, and a physical examination was performed. Ten-year cardiovascular risk of death was...
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Medical Image Dataset Annotation Service (MIDAS)
PublikacjaMIDAS (Medical Image Dataset Annotation Service) is a custom-tailored tool for creating and managing datasets either for deep learning, as well as machine learning or any form of statistical research. The aim of the project is to provide one-fit-all platform for creating medical image datasets that could easily blend in hospital's workflow. In our work, we focus on the importance of medical data anonimization, discussing the...
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Diamond-based protective layer for optical biosensors
PublikacjaOptical biosensors have become a powerful alternative to the conventional ways of measurement owing to their great properties, such as high sensitivity, high dynamic range, cost effectiveness and small size. Choice of an optical biosensor's materials is an important factor and impacts the quality of the obtained spectra. Examined biological objects are placed on a cover layer which may react with samples in a chemical, biological...