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Wyniki wyszukiwania dla: HT-29 CELL LINE, ESCHERICHIA COLI, PAI I, TRYPSIN-LIKE ACTIVITY, INFECTION
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Process control strategy deployment with part measuring activity in a flexible machining cell
PublikacjaRozwinięto zintegrowany model planowania i sterowania przebiegu procesu w rzeczywistym, zrobotyzowanym elastycznym gnieździe obróbki (EGO) ze współrzędnościową maszyną pomiarową, realizującą funkcje pomiarowo-kontrolne wytwarzanych przedmiotów. Analizowano współzależności wybranych heurystycznych planów kontroli przedmiotów oraz strategii szeregowania operacji procesów technologicznych, z zastosowaniem programowalnych modeli symulacyjnych...
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Towards the value-based design of on-line services
PublikacjaThe paper identifies economic factors shaping customer bahaviour in on-line services in two interrelated dimensions; (1) economic needs and requirements, relevant to expected benefits and values perceived by customers; (2) technical components, allowing technical realization of on-line services. Technical components were cathegorized into four groups, creating so-called VIPR model: Visual, Interactive, Process and Relationship-relevant...
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The Effects of Cellular Membrane Damage on the Long-Term Storage and Adhesion of Probiotic Bacteria in Caco-2 Cell Line
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Monitoring of current collectors on the railway line
PublikacjaProper cooperation the current collectors and the overhead line is a pre-requisite for reliable and safe operation of railway transport. Instances of maladjustment and, in some cases, damage to the current collectors, occur between periodic inspections of the rolling stock. In order to detect such anomalies quickly, the test stand was developed, with the aim of monitoring the technical state of the current collectors under operating...
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Antibacterial activity of gelatin-based films incorporated with chitosan or silver
PublikacjaFolie żelatynowe z dodatkiem srebra jonowego powodowały redukcję komórek Escherichia coli i Staphylococcus aureus o 90% pod powierzchnią folii. Nie obserwowano natomiast strefy zahamowania wzrostu dookoła krążków folii. W przypadku filmów chitozanowych lub żelatynowo-chitozanowych ich przeciwdrobnoustrojowa aktywność zależała od stopnia deacetylacji chitozanu.
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Angiopoietin-like growth factor-derived peptides as biological activators of adipose-derived mesenchymal stromal cells
PublikacjaAdipose-derived mesenchymal stromal cells (AD-MSCs) are an essential issue in modern medicine. Extensive preclinical and clinical studies have shown that mesenchymal stromal/stem cells, including AD-MSCs, have specific properties (ability to differentiate into other cells, recruitment to the site of injury) of particular importance in the regenerative process. Ongoing research aims to elucidate factors supporting AD-MSC culture...
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Synthesis and biological activity of mycophenolic acid-amino acid derivatives
PublikacjaIn search of new immunosuppressants, mycophenolic acid (MPA) was coupled with amino acid methyl esters followed by hydrolysis to analogs bearing free carboxylic groups. The obtained compunds were tested in vitro as growth inhibitors of lymphoid cell line (Jurkat) and human peripheral blood mononuclear cells (PBMC) from healthy donors. According to obtained results recovering of free carboxylic group increased their activity. Additionally,...
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Glucose oxidase as an important yet overlooked factor determiningthe antibacterial activity of bee pollen and bee bread
PublikacjaBee pollen (BP) and bee bread (BB) have attracted great attention due to their biological activities including antibacterial activity. However, the mechanism of antibacterial activity is largely unknown. Therefore, we aimed to characterise the antibacterial effect of BP and BB aqueous extracts against bacterial pathogens (Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli, Proteus mirabilis and Enterococcus faecalis)...
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Assessing Word Difficulty for Quiz-Like Game
PublikacjaMappings verification is a laborious task. Our research aims at providing a framework for manual verification of mappings using crowdsourcing approach. For this purpose we plan on implementing a quiz like game. For this purpose the mappings have to be evaluated in terms of difficulty to better present texts in respect of game levels. In this paper we present an algorithm for assessing word difficulty. Three approaches...
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In silico modelling for predicting the cationic hydrophobicity and cytotoxicity of ionic liquids towards the Leukemia rat cell line, Vibrio fischeri and Scenedesmus vacuolatus based on molecular interaction potentials of ions
PublikacjaIn this study we present prediction models for estimating in silico the cationic hydrophobicity and the cytotoxicity (log [1/EC50]) of ionic liquids (ILs) towards the Leukemia rat cell line (IPC-81), the marine bacterium Vibrio fischeri and the limnic green algae Scenedesmus vacuolatus using linear free energy relationship (LFER) descriptors computed by COSMO calculations. The LFER descriptors used for the prediction model (i.e....
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Novel 5-Substituted 2-(Aylmethylthio)-4-chloro-N-(5-aryl-1,2,4-triazin-3-yl)benzenesulfonamides: Synthesis, Molecular Structure, Anticancer Activity, Apoptosis-Inducing Activity and Metabolic Stability
PublikacjaA series of novel 5-substituted 2-(arylmethylthio)-4-chloro-N-(5-aryl-1,2,4-triazin-3-yl) benzenesulfonamide derivatives 27–60 have been synthesized by the reaction of aminoguanidines with an appropriate phenylglyoxal hydrate in glacial acetic acid. A majority of the compounds showed cytotoxic activity toward the human cancer cell lines HCT-116, HeLa and MCF-7, with IC50 values below 100 M. It was found that for the analogues 36–38...
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Slow-wave fractal-shaped compact microstrip resonant cell
PublikacjaA novel fractal-shaped compact microstrip resonant cell (CMRC) featuring a strong slow-wave effect has been presented. Its vital usefulness in the process of microstrip line miniaturisation has been proved and experimentally validated on the basis of a compact 3-dB branch-line coupler illustrating the possibilities of the approach. A prototype example structure has been designed to mirror the characteristics of a conventional device,...
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Genetic and pharmacologic proteasome augmentation ameliorates Alzheimer’s-like pathology in mouse and fly APP overexpression models
PublikacjaThe proteasome has key roles in neuronal proteostasis, including the removal of misfolded and oxidized proteins, presynaptic protein turnover, and synaptic efficacy and plasticity. Proteasome dysfunction is a prominent feature of Alzheimer’s disease (AD). We show that prevention of proteasome dysfunction by genetic manipulation delays mortality, cell death, and cognitive deficits in fly and cell culture AD models. We developed...
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On-line Ramsey Numbers of Paths and Cycles
PublikacjaConsider a game played on the edge set of the infinite clique by two players, Builder and Painter. In each round, Builder chooses an edge and Painter colours it red or blue. Builder wins by creating either a red copy of $G$ or a blue copy of $H$ for some fixed graphs $G$ and $H$. The minimum number of rounds within which Builder can win, assuming both players play perfectly, is the \emph{on-line Ramsey number} $\tilde{r}(G,H)$. In...
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Fusion of Taq DNA polymerase with single-stranded DNA binding-like protein of Nanoarchaeum equitans—Expression and characterization
PublikacjaDNA polymerases are present in all organisms and are important enzymes that synthesise DNA molecules. They are used in various fields of science, predominantly as essential components for in vitro DNA syntheses, known as PCR. Modern diagnostics, molecular biology and genetic engineering need DNA polymerases which demonstrate improved performance. This study was aimed at obtaining a new NeqSSB-TaqS fusion DNA polymerase from the...
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Structure–bioavailability relationship study of genistein derivatives with antiproliferative activity on human cancer cell
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The effect of Ag, Au, Pt, and Pd on the surface properties, photocatalytic activity and toxicity of multicomponent TiO2-based nanomaterials
PublikacjaMulticomponent TiO2-based nanomaterials (MC-NMs) show better physicochemical properties than their individual components or bulk materials. However, the same unique properties that offer innovative applications might also pose unknown risks to human health and the environment. In this context, TiO2- based nanomaterials with a mixture of noble metal precursors (Ag, Au, Pt, and Pd) for large-scale technological applications in air...
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Post-match recovery profile of leukocyte cell subsets among professional soccer players
PublikacjaThis study assessed the impact of cumulative match time on the distribution of CD45+ cell subtests in the capillary blood of professional soccer players. Twenty-two males (aged 18–30 years) took part in the 36-week study. Participants playing up to 540 in cumulative match time and less than 30 min in each single match during the observation period formed the control group. White blood cell (WBC) phenotyping and creatine kinase...
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Genetic and pharmacologic proteasome augmentation ameliorates Alzheimer’s-like pathology in mouse and fly APP overexpression models
PublikacjaThe proteasome has key roles in neuronal proteostasis, including the removal of misfolded and oxidized proteins, presynaptic protein turnover, and synaptic efficacy and plasticity. Proteasome dysfunction is a prominent feature of Alzheimer’s disease (AD). We show that prevention of proteasome dysfunction by genetic manipulation delays mortality, cell death, and cognitive deficits in fly and cell culture AD models. We developed...
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Changes in subcellular localization of visfatin in human colorectal HCT-116 carcinoma cell line after cytochalasin B treatment
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Genotoxicity of selected pharmaceuticals, their binary mixtures, and varying environmental conditions – study with human adenocarcinoma cancer HT29 cell line
PublikacjaPharmaceutical residues are present in the environment in mixtures and their adverse effects may also result from interactions that occur between compounds. Studies presented in this work focus on genotoxicity of pharmaceuticals from different therapeutic groups in mixtures and in individual solutions impacted with different environmental conditions assessed using comet assay (alkaline approach). Binary mixtures of pharmaceuticals...
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Xanthone synthetic derivatives with high anticandidal activity and positive mycostatic selectivity index values
PublikacjaWith the current massive increases in drug-resistant microbial infection as well as the significant role of fungal infections in the death toll of COVID-19, discovering new antifungals is extremely important. Natural and synthetic xanthones are promising derivatives, although only few reports have demonstrated their antifungal mechanism of action in detail. Newly synthetized by us xanthone derivative 44 exhibited strong antifungal...
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Successful Treatment of Persistent SARS-CoV-2 Infection in a B-Cell Depleted Patient with Activated Cytotoxic T and NK Cells: A Case Report
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Assestment of the anti-cancer activity of the copper complexes with imidazole and pivalato ligands
PublikacjaDespite the development of science and technology progress so far there have not been found effective drugs for cancer. Many coordination compounds were investigated due to their antitumor potential. The most known cis-diamminedichloroplatinum(II) is used as anti-cancer therapeutic agent. The copper complexes are the coordination compounds possessing anti-tumour properties. Their capability to kill cancer cells is mainly linked...
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Ochratoxin A, deoxynivalenol, T-2 and HT-2 toxins – occurrence in food and their effect on the human body
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Ionic liquid as morphology-directing agent of two-dimensional Bi2WO6: New insight into photocatalytic and antibacterial activity
PublikacjaAn efficient and durable utilization of light to drive photocatalytic reactions still requires the overcoming of barriers. Herein, two-dimensional (2D) ultrathin IL_Bi2WO6 (IL_BWO) photocatalysts were prepared for the first time via ionic liquid-assisted hydrothermal route by adjusting the amount of tetrabutylammonium chloride [TBA][Cl], synthesis temperature and duration. IL played the role of morphology-directing agent given...
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Fluconazole resistant Candida auris clinical isolates have increased levels of cell wall chitin and increased susceptibility to a glucosamine-6-phosphate synthase inhibitor
PublikacjaIn 2009 Candida auris was first isolated as fungal pathogen of human disease from ear canal of a patient in Japan. In less than a decade, this pathogen has rapidly spread around the world and has now become a major health challenge that is of particular concern because many strains are resistant to multiple class of antifungal drugs. The lack of available antifungals and rapid increase of this fungal pathogen provides an incentive...
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Hierarchia ważności wymagań studentów wobec usług on-line
PublikacjaW artykule ustalono hierarchię wymagań studentów wobec usług on-line na podstawie danych z badania ankietowego, w którym zastosowano skalę porównywania parami. Wyniki pokazują, że badani oczekują przede wszystkim korzystnej ceny usługi on-line, a następnie bezpieczeństwa jej świadczenia. Na kolejnej pozycji znajdują się następujące wymagania: niskie dodatkowe wydatki, dostęp do odpowiedniej ilości informacji, wygodne korzystanie...
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Impedance monitoring of fuel cell stacks
PublikacjaThis paper presents an innovative, electrochemical impedance method for monitoring of electrochemical behaviour of a multi-cell, direct methanol fuel cell (DMFC) device. This method not only provides classical voltage changes at successive cells but also allows their detailed impedance behaviour to be presented. Impedance characteristics of individual cells within a fuel cell stack (depending on actual operating conditions) are...
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THE PROTECTIVE MEASURES AGAINST SARS-COV-2 INFECTION IN THE SEAFOOD COMPANY FROM THE PERSPECTIVE OF THE EMPLOYEES
PublikacjaPurpose: To identify and discuss the protective measures implemented to prevent SARS-CoV-2 infection among employees. Design/methodology/approach: The four-stage course of research. Case study and structured interviews with all employees, directly and indirectly, involved in food processing. Research questions: (R1) What measures have been taken to prevent the risk of infection among employees? (R2) What activities and responsibilities...
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Design, Chemical Synthesis and Kinetic Studies of Trypsin Chromogenic Substrates Based on the Proteinase Binding Loop of Cucurbita maxima Trypsin Inhibitor (CMTI-III)
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May Staphylococcus lugdunensis Be an Etiological Factor of Chronic Maxillary Sinuses Infection?
PublikacjaStaphylococcus lugdunensis is an opportunistic pathogen found in the healthy human skin microbiome bacterial community that is able to cause infections of diverse localization, manifestation, and course, including laryngological infections, such as necrotizing sinusitis. Chronic maxillary sinusitis is a disease present in up to one third of European and American populations, and its etiology is not fully described. Within this...
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Synthesis and antiproliferative activity of new mycophenolic acid conjugates with adenosine derivatives
PublikacjaNew conjugates of mycophenolic acid (MPA) and adenosine derivatives were synthesized and assessed as potential immunosuppressants on Jurkat cell line and peripheral blood mononuclear cells (PBMC) from healthy donors. As compared to MPA, all compounds were found to be more active against Jurkat cell line. The antiproliferative activities were compared with MPA and adenosine, in both 2′,3′-O-isopropylidene protected and free hydroxyl...
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Bioactive Compounds in Aegopodium podagraria Leaf Extracts and Their Effects against Fluoride-Modulated Oxidative Stress in the THP-1 Cell Line
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Solid Phase Synthesis and Biological Activity of Tuftsin Conjugates
PublikacjaNew tuftsin/retro-tuftsin conjugates were designed and synthesized using a classical fluorenylmethoxycarbonyl (Fmoc) solid phase procedure. All the peptide conjugates were divided into three series: 1,4-dihydroxyanthraquinone (type A), 1-nitroacridine (type B), and 4-carboxyacridone (type C) derivatives. In type A conjugates, the N-terminal group of the peptide chain is directly connected to the anthraquinone ring at C1 (Scheme...
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Badania użyteczności usług on-line: pozainformatyczne determinanty satysfakcji klienta
PublikacjaArtykuł omawia proponowaną metodykę badań użyteczności usług on-line z udziałem użytkowników oraz jej zastosowanie. Proponowana metodyka jest ukierunkowana przede wszystkim na analizę wpływu pozainformatycznych (głownie ekonomicznych) czynników na satysfakcje klientów usług on-line. Z pilotażowego zastosowania metodyki wynika możliwość przeniesienia w znacznym zakresie metod badawczych z obszaru interakcji człowiek-komputer (HCI)...
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Sulfanyl porphyrazines: Molecular barrel-like self-assembly in crystals, optical properties and in vitro photodynamic activity towards cancer cells
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Synthesis and antimicrobial activity of truncated fragments and analogs of citropin 1.1: The solution structure of the SDS micelle-bound citropin-like peptides
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Design considerations for compact microstrip resonant cells dedicated to efficient branch-line miniaturization
PublikacjaA conventional compact microstrip resonant cell (CMRC)has been thoroughly investigated to enhance its slow-wave properties and subsequently ensure an efficient miniaturization of a microstrip circuit. The geometry of a classic CMRC has been improved in terms of slowwave effect in two progressive steps: (i) a single-element topology has been replaced with a double-element one and (ii) a high-impedance section has been refined by...
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Wykorzystanie narzędzi współpracy on-line w środowisku akademickim
PublikacjaWspółpraca on-line to temat coraz częściej poruszany w środowisku naukowym i biznesowym. Odpowiednie wykorzystanie dostępnych narzędzi informatycznych wspomaga komunikację i planowanie eksperymentów, a także podejmowanie decyzji i konsultacje na odległość zarówno przed, jak i na poszczególnych etapach realizacji danego projektu. Zastosowanie nowoczesnych rozwiązań powinno mieć miejsce także w środowisku akademickim, a studenci...
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Influence of finishing colour on the efficiency of automated production line for wooden doors
PublikacjaPorta KMI Poland S.A. company has implemented a fully automated intelligent technological line TechnoPORTA for customized mass-production of technical door leaves. Each door leaf is provided with a unique QR code. It allows the line modules to individually adjust the machining parameters to the currently processed element according to the IT controlling system. Before en-tering the TechnoPorta line, the door leaves are not sorted,...
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Assurance Case Patterns On-line Catalogue
PublikacjaAssurance case is an evidence-based argument demonstrating that a given property of a system (e.g. safety, security) is assured. Assurance cases are developed for high integrity systems, as in many industry domains such argu-ment is explicitly required by regulations. Despite the fact that each assurance case is unique, several reusable argument patterns have been identified and pub-lished. This paper reports work on development...
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Pomiar on-line zmiennej częstotliwości metodą cyfrową
PublikacjaW cyfrowym pomiarze częstotliwości on-line dysponujemy informacją o długościach przedziałów międzyimpulsowych poprzedzających chwilę próbkowania. W artykule porównano pomiar częstotliwości na podstawie ostatniego przedziału i metodę wykorzystującą ekstrapolację z dwóch ostatnich przedziałów. Wykonano analizę dla liniowej i sinusoidalnej zmiany częstotliwości. Zaproponowano metodę, w której sposób wyznaczenia częstotliwości zależy...
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The immunology of Bordetella pertussis infection and vaccination
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Antitumor Activity of Triazine Mimic Antibiotics for DNA-binding Implications (Impressive Activity in Vitro Against a Variety of Tumor Types in the NCI-60 Screen): NSC 710607 To Fight HCT-116 Human Colon Carcinoma Cell Lines in Vivo Using the Hollow Fiber Assay and Xenograft Mouse Models
PublikacjaPurpose Successful clinical applications of DNA-directed selective cytotoxic agents disrupt the vital replication/transcription processes and ultimately lead to cancer cell death. This study aimed to examine the growth screen of two lead triazine compounds in a number of cell lines and xenografts and to develop anticancer agents with noncovalent binding affinity bringing fewer side effects. Methods The NCI initial hollow...
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Towards Methodology for User Experience Measurement in On-line Services
PublikacjaArtykuł prezentuje wyniki badań, których celem była identyfikacja czynników kształcących jakość postrzeganą wybranych usług on-line udostępnianych przez Internet oraz ocena wpływu czynników kształtujących lojalność ich użytkowników. Badania wykazały, że czynnikami najbardziej istotnymi są: ''atrakcyjna cena'', następnie ''poczucie bezpieczeństwa'' oraz ''wyczerpująca informacja'', a w dalszej kolejności ''wygoda'' korzystania z...
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Inhibitors of Matriptase‐2 Based on the Trypsin Inhibitor SFTI‐1
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L-tyrosine and L-dihydroxyphenylalanine as hormone-like regulators of melanocyte functions
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Evaluating the antibacterial activity of muramyl dipeptide derivatives, retro-tuftsin derivatives, and anthraquinone oligopeptides against a range of pathogenic bacteria
PublikacjaSearch for new and efficient antibiotic is crucial because of microbial drug resistance and problems with side effects of the administered medication. In this study, we evaluate the in vitro microbiological activity of muramyl dipeptide derivatives, retro-tuftsin derivatives (i.e., tuftsin with reversed amino acid sequences), and combinations of retro-tuftsin derivatives with substituted anthraquinones. The potency of the investigated...
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Role of size scale of ZnO nanoparticles and microparticles on toxicity toward bacteria and osteoblast cancer cells
PublikacjaThe specific role of size scale, surface capping, and aspect ratio of zinc oxide (ZnO) particles on toxicity toward prokaryotic and eukaryotic cells was investigated. ZnO nano and microparticles of controlled size and mor- phology were synthesized by wet chemical methods. Cytotoxicity toward mammalian cells was studied using a human osteoblast cancer cell line and antibacterial activity using Gram-negative bacteria (Escherichia...