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Wyniki wyszukiwania dla: drug screening platform
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Communication as a Factor Limiting University-Business Cooperation
PublikacjaObjective - Despite the broad extent of the scientific activity dealing with university-business cooperation, Poland has yet to develop a satisfactory cooperation strategy that takes business needs into account. This issue is still relevant due to the need for continuous improvement and resulting benefits aimed at improving enterprise competitiveness. Methodology/Technique - Authors of this article attempt to select an overriding...
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The Touristification of Italian Historic City Centres: The Lesson for Central Europe about the Airbnb Eruption
PublikacjaThe unparalleled scale of the recent growth in tourism – the rise of the number of temporary visitors – could not have emerged without the impact on other socio‑economic aspects, namely, a change on the part of the destinations. Especially historic city centres are vulnerable to such an impact that could be manifested through diverse transformations of public space usage, housing market economics, availability of services, employment...
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Salinity enhances high optically active L-lactate production from co-fermentation of food waste and waste activated sludge: Unveiling the response of microbial community shift and functional profiling
PublikacjaLactic acid (LA), a versatile platform molecule, can be fermented from organic wastes, such as food waste and waste activated sludge. In this study, an efficient approach using salt, a component of food waste as an additive, was proposed to increase LA production. The LA productivity was increased at 10 g NaCl/L and optical pure L-lactate was obtained at 30 g NaCl/L. The enhancement of LA was in accordance with the increased solubilization...
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Implementacja w FPGA algorytmu detekcji krawędzi obrazu w czasie rzeczywistym
PublikacjaW artykule przedstawiono projekt architektury oraz implementację układową toru przetwarzania wstępnego obrazu z modułem detekcji krawędzi. Układ został zaimplementowany w FPGA Intel Cyclone. Zrealizowany moduł wykorzystuje pięć wybranych algorytmów wykrywania krawędzi, w tym Robertsa, Sobela i Prewitt.
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First report on echinocandin resistant Polish Candida isolates
PublikacjaPurpose: Candida spp. are ranked as one of the four major causative agents of fungal infections. The number of infections caused by Candida species resistant to fluconazole, which is applied as the first line drug in candidiasis treatment, increases every year. In such cases the application of echinocandin is necessary. Echinocandin susceptibility testing has become a routine laboratory practice in many countries due to the increasing...
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Phage Therapy—Challenges, Opportunities and Future Prospects
PublikacjaThe increasing drug resistance of bacteria to commonly used antibiotics creates the need to search for and develop alternative forms of treatment. Phage therapy fits this trend perfectly. Phages that selectively infect and kill bacteria are often the only life-saving therapeutic option. Full legalization of this treatment method could help solve the problem of multidrug-resistant infectious diseases on a global scale. The aim of...
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Mechanism of reaction of RNA-dependent RNA polymerase from SARS-CoV-2
PublikacjaWe combine molecular dynamics, statistical mechanics, and hybrid quantum mechanics/molecular mechanics simulations to describe mechanistically the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA-dependent RNA polymerase (RdRp). Our study analyzes the binding mode of both natural triphosphate substrates as well as remdesivir triphosphate (the active form of drug), which is bound preferentially over ATP by RdRp while...
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TiO2-based magnetic nanocomposites with core-shell structure
PublikacjaThe main aim of the doctoral dissertation was preparation and characterization of photocatalysts, with particular emphasis on modified titanium (IV) oxide photocatalysts, which can be applied for the degradation of organic pollutants not susceptible to biodegradation. A particularly important aspect of the work was the development of preparation method of nanocomposites with the magnetic core-shell and photocatalyst shell (TiO2)...
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Effect of choline chloride based natural deep eutectic solvents on aqueous solubility and thermodynamic properties of acetaminophen
PublikacjaIn this work, natural deep eutectic solvents (NADESs) containing choline chloride as hydrogen bond acceptor and 1,2-propanediol, malic acid and tartaric acid as hydrogen bond donors have been synthesized and applied to enhance the aqueous solubility of model sparingly water-soluble drug – acetaminophen. The results indicate that the greatest impact on the solubility of acetaminophen have deep eutectic solvents based on 1,2-propanediol...
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Szacowanie maksymalnej mocy generacji rozproszonej w systemie elektroenergetycznym
PublikacjaW monografii przedstawiono metodykę szacowania maksymalnej mocy zainstalowanej, tzw. generacji rozproszonej. Metodyka ta umożliwia określenie wartości maksymalnej mocy możliwej do przyłączenia w danym miejscu (miejscach) systemu elektroenergetycznego w źródłach generacji rozproszonej, a ponadto pozwala na ocenę wariantów przyłączenia. W metodyce wykorzystuje się funkcję celu, która uwzględnia wymagania wobec źródeł energii elektrycznej...
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The development of an underwater telephone for digital communication purposes
PublikacjaThe underwater telephone HTL-10 has been designed to provide voice and data communication between helicopter and submarines using acoustic waves. It works in a half-duplex mode and uses analogue power-efficient modulation in the form of a single side-band, suppressed carrier, in a wide range of frequencies. It generates the transmitted signal, and processes the received signals. It is implemented with the use of digital signal...
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Metodyka szacowania maksymalnej generacji rozproszonej ulokowanej w elektrowniach wiatrowych
PublikacjaPraca przedstawia metodykę szacowania maksymalnej mocy zainstalowanej tzw. generacji rozproszonej. Metodyka ta umożliwia określenie wartości maksymalnej mocy, możliwej do przyłączenia w danym miejscu (miejscach) systemu elektroenergetycznego w źródłach generacji rozproszonej, a w tym pozwala na ocenę wariantów przyłączenia. W metodyce wykorzystuje się funkcję celu, która uwzględnia wymagania stawiane źródłom energii elektrycznej...
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Do online reviews reveal mobile application usability and user experience? The case of WhatsApp
PublikacjaThe variety of hardware devices and the diversity of their users imposes new requirements and expectations on designers and developers of mobile applications (apps). While the Internet has enabled new forms of communication platform, online stores provide the ability to review apps. These informal online app reviews have become a viral form of electronic wordof-mouth (eWOM), covering a plethora of issues. In our study, we set ourselves...
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Diagnostics of the tram track shape with the use of the global positioning satellite systems (GPS/Glonass) measurements with a 20 Hz frequency sampling
PublikacjaSatellite geodetic measurements used in the diagnosis of railway tracks require professional receivers and a very high frequency rate of data processing. It stems from a significant speed (10 km/h) kinematic measurements carried out during the passage of a measuring platform. The survey results (positions) of deformed railroad track have waveforms nature requiring additional processing methods and approximations. Due to the announcement...
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Experience-Based Decisional DNA (DDNA) to Support Product Development
PublikacjaKnowledge and experience are important requirements for product development. The aim of this paper is to propose a systematic approach for industrial product development. This approach uses smart knowledge management system comprising of Set of Experience Knowledge Structure and Decisional DNA (DDNA) along with Virtual Engineering Tools (Virtual engineering object, Virtual engineering process, and Virtual engineering factory)....
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Using Moodle as a Solution to Interdisciplinary E-collaboration Issues
PublikacjaRapid technological development in recent years has contributed to numerous changes in many areas of life, including education and communication. Establishing interdisciplinary collaboration brings many benefits, however, it is often associated with numerous problems and inconveniences, as well as the need of constant improvement, lifelong learning, professional development (CPD) and finding an effective way of information transferring....
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MobileNet family tailored for Raspberry Pi
PublikacjaWith the advances in systems-on-a-chip technologies, there is a growing demand to deploy intelligent vision systems on low-cost microcomputers. To address this challenge, much of the recent research has focused on reducing the model size and computational complexity of contemporary convolutional neural networks (CNNs). The state-of-the-art lightweight CNN is MobileNetV3. However, it was designed to achieve a good trade-off between...
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Determination of the tram track axis using a multi receiver GNSS measurement system
PublikacjaThis article refers to research, that has been conducted by an interdisciplinary research team from the Gdańsk University of Technology and the Maritime University in Gdynia since 2009. These investigation concerns the determination of a railway track axis using the mobile satellite measurement technique. Following the dynamic development of GNSS techniques, that could be seen in the last decade, the team carried out further experiments...
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Validation Process for Computational Model of Full-Scale Segment for Design of Composite Footbridge
PublikacjaExperimental tests and numerical simulations of a full-scale segment of a foot and cycle bridge made of polymer composites are presented in the paper. The analysed structure is made of sandwich panels, which consist of glass fibre reinforced polymer (GFRP) multi-layered laminate faces and a PET foam (obtained from recycling) core. The dimensions of the segment cross-section are the same as for the target footbridge; however, span...
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E-learning course "International comparative studies on SMEs"
PublikacjaProjekt Leonardo da Vinci "International comparative studies and course development on SMEs" został zainspirowany poprzednim projektem LdV "A European Diploma in SME Management". Bazując na poprzednich doświadczeniach projektowych zaproponowano opracowanie struktur dla opisania narodowych systemów małych i średnich przedsiębiorstw (ang. SME Small Media Enterprises) przy wykorzystaniu dostępnych krajowych danych. Udowodniono, że...
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Evaluation of polycaprolactone as a new sorbent coating for determination of polar organic compounds in water samples using membrane–SPME
PublikacjaCommercially available solid-phase microextraction fibers used for isolation of polar analytes are based on the adsorption phenomenon. In consequence, typical limitations bonded with analytes displacement and matrix effects are very frequent. In the present study, alternative solution is described. Polycaprolactone (PCL) was used for the first time as sorbent to isolate polar organic compounds from water samples using the membrane–solid-phase...
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Subarachnoid Space: New Tricks by an Old Dog
PublikacjaPurpose: The purpose of the study was to: (1) evaluate the subarachnoid space (SAS) width and pial artery pulsation in both hemispheres, and (2) directly compare magnetic resonance imaging (MRI) to near-infrared transillumination/backscattering sounding (NIR-T/BSS) measurements of SAS width changes in healthy volunteers.Methods: The study was performed on three separate groups of volunteers, consisting in total of 62 subjects (33...
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Study on a polish peat bog “Rucianka” as a source of yeast strains capable of effective phenol biodegradation
PublikacjaPhenol is one of the most widely distributed environmental pollutants which can be found in wastewaters and industrial effluents. Due to its toxicity and resistance to self-degradation, it could become even lethal for humans and animals. The treatment of this toxic compound is focused on psychical–chemical methods, although biological treatment of phenol is preferable for economic aspects related to relatively...
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The New Test Procedure for Group-Type Composition of Base Oils of Lubricating Oils, Especially Emitted into the Environment
PublikacjaMineral base oil, a product of multistep fine refining of the relevant fractions from vacuum distillation of crude oil, is a main component of so-called mineral lubricating oils containing aliphatic and alicyclic substituted aromatic hydrocarbons, i.e., derivatives of benzene and biphenyl. Mineral lubricating oil is composed mostly of mineral base oil and a low amount of enriching additives, most often products of advanced organic...
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Magnetic deep eutectic solvents as efficient media for extraction of furfural and 5-hydroxymethylfurfural from aqueous samples
PublikacjaThe extraction of furfural (FF) and 5-hydroxymethylfurfural (HMF) from hydrolysates is currently one of the main challenges in bio-refinery. In this work, the separation of FF and HMF from the aqueous phase was carried out using a new type of green solvents – Magnetic Deep Eutectic Solvents (MDES). A conductor-like screening model for realistic solvents (COSMO-RS) was used for the preselection of 400 MDES. MDES which exhibit the...
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Interpretable deep learning approach for classification of breast cancer - a comparative analysis of multiple instance learning models
PublikacjaBreast cancer is the most frequent female cancer. Its early diagnosis increases the chances of a complete cure for the patient. Suitably designed deep learning algorithms can be an excellent tool for quick screening analysis and support radiologists and oncologists in diagnosing breast cancer.The design of a deep learning-based system for automated breast cancer diagnosis is not easy due to the lack of annotated data, especially...
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Attention-Based Deep Learning System for Classification of Breast Lesions—Multimodal, Weakly Supervised Approach
PublikacjaBreast cancer is the most frequent female cancer, with a considerable disease burden and high mortality. Early diagnosis with screening mammography might be facilitated by automated systems supported by deep learning artificial intelligence. We propose a model based on a weakly supervised Clustering-constrained Attention Multiple Instance Learning (CLAM) classifier able to train under data scarcity effectively. We used a private...
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Olfactory receptor-based biosensors as potential future tools in medical diagnosis
PublikacjaThe detection of biomarkers is the future of non-invasive medical diagnosis and screening. Discovery and identification of reliable disease specific volatile organic compounds is dependent on repeatable, accurate analysis of trace level gaseous analytes mainly in breath samples. Natural variety of the olfactory systems and the compounds capable of gas molecules binding creates wide possibilities of acquisition and implementation...
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Determination of Odor Air Quality Index (OAQII) Using Gas Sensor Matrix
PublikacjaThis article presents a new way to determine odor nuisance based on the proposed odor air quality index (OAQII), using an instrumental method. This indicator relates the most important odor features, such as intensity, hedonic tone and odor concentration. The research was conducted at the compost screening yard of the municipal treatment plant in Central Poland, on which a self-constructed gas sensor array was placed. It consisted...
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Embedded gas sensing setup for air samples analysis
PublikacjaThis paper describes a measurement setup (eNose) designed to analyze air samples containing various volatile organic compounds (VOCs). The setup utilizes a set of resistive gas sensors of divergent gas selectivity and sensitivity. Some of the applied sensors are commercially available and were proposed recently to reduce their consumed energy. The sensors detect various VOCs at sensitivities determined by metal oxide sensors’ technology...
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New Carvone-Based Deep Eutectic Solvents for Siloxanes Capture from Biogas
PublikacjaDuring biogas combustion, siloxanes form deposits of SiO2 on engine components, thus shortening the lifespan of the installation. Therefore, the development of new methods for the purification of biogas is receiving increasing attention. One of the most effective methods is physical absorption with the use of appropriate solvents. According to the principles of green engineering, solvents should be biodegradable, non-toxic, and...
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How thermal stability of ionic liquids leads to more efficient TiO2-based nanophotocatalysts: Theoretical and experimental studies
PublikacjaIonic liquids (ILs) containing distinct nitrogen-bearing organic cations (pyridinium, pyrrolidinium, imidazolium, ammonium, morpholinium) were first used for the preparation of 23 IL-TiO2 types of composites by ionic liquid assisted solvothermal synthesis. These 23 optimal ILs structures (i.e. compounds exhibiting an optimal combination of specific properties, functionality, and safety) for synthesis and experimental validation...
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Horyzont energoelektroniczny obiektów morskich
PublikacjaW artykule zaprezentowano współczesne kierunki rozwoju energoelektroniki, w tym w szczególności dotyczące obiektów morskich. Przedstawiono podstawowe parametry aktualnie stosowanych w energoelektronice przyrządów półprzewodnikowych, jak również wykazano interdyscyplinarny charakter rozwoju tej dziedziny. Na przykładzie wybranych urządzeń energoelektronicznych przedstawiono ich komercyjne zastosowania oraz podział i miejsce w łańcuchu...
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Antitumor 1-nitroacridine derivative C-1748 induces significant apoptosis in pancreatic cancer cells.
PublikacjaPancreatic cancer is the fifth leading cause of cancer death and has the lowest survival rate of any solid cancer in the industrial countries. The poor prognosis of pancreatic cancer results from its tendency for late presentation, aggressive invasion, early metastasis, and resistance to chemotherapy. Gemcitabine still remains the best chemotherapeutic agent available for the treatment of advanced pancreatic cancer. However, gemcitabine...
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Projekt badawczy BRIK: Opracowanie innowacyjnej metody wyznaczania precyzyjnej trajektorii pojazdu szynowego
PublikacjaW artykule przedstawiono podstawowe informacje dotyczące projektu badawczego realizowanego na zlecenie Narodowego Centrum Badań i Rozwoju oraz Spółki PKP Polskie Linie Kolejowe S. A. przez Konsorcjum Politechniki Gdańskiej i Uniwersytetu Morskiego w Gdyni. Projekt obejmuje wykorzystanie nowoczesnych metod pomiarowych, takich jak techniki pozycjonowania satelitarnego GNSS, pomiary inercyjne INS oraz skaning laserowy LS, w procesie...
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Application of Multivariate Adaptive Regression Splines (MARSplines) for Predicting Hansen Solubility Parameters Based on 1D and 2D Molecular Descriptors Computed from SMILES String
PublikacjaA new method of Hansen solubility parameters (HSPs) prediction was developed by combining the multivariate adaptive regression splines (MARSplines) methodology with a simple multivariable regression involving 1D and 2D PaDEL molecular descriptors. In order to adopt the MARSplines approach to QSPR/QSAR problems, several optimization procedures were proposed and tested. The effectiveness of the obtained models was checked via standard...
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Common methods for the chiral determination of amphetamine and related compounds II: Capillary electrophoresis and nuclear magnetic resonance
PublikacjaAmphetamine group and related ring-substituted substances are generally synthetic compounds, belonging to one of the most heavily abused drug groups in recent years. Some compounds in this class also originate from plants. Analysis of the enantiomers of AM-type compounds and metabolites is extremely important for a number of scientific disciplines. From studies of biological activity or mechanisms through determination of precursor...
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Body surface area formulae: an alarming ambiguity
PublikacjaBody surface area (BSA) plays a key role in several medical fields, including cancer chemotherapy, transplantology, burn treatment and toxicology. BSA is often a major factor in the determination of the course of treatment and drug dosage. A series of formulae to simplify the process have been developed. Because easy-to-identify, yet general, body coefficient results of those formulae vary considerably, the question arises as to...
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Novel fused pyran derivatives induce apoptosis and target cell cycle progression in anticancer efficacy against multiple cell lines.
PublikacjaNitrogen-based heterocycles such as pyrazole, imidazole, 1,2,4-triazole, benzimidazole, and benzotriazole substituted fused pyran derivatives (6a–e, 8a–e, 10a–e, 12a–e,&14a–e) have been synthesized and tested for their in vitro anticancer efficacies against MCF7, A549, and HCT116 cancer cell lines. Among the compounds, 6e, 14b, and 8c were identified as the most potent against MCF7, A549, and HCT116, with IC50 values of 12.46 2.72...
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In Vitro and In Vivo Imaging-Based Evaluation of Doxorubicin Anticancer Treatment in Combination with the Herbal Medicine Black Cohosh
PublikacjaAs a substitution for hormone replacement therapy, many breast cancer patients use black cohosh (BC) extracts in combination with doxorubicin (DOX)-based chemotherapy. In this study, we evaluated the viability and survival of BC- and DOX-treated MCF-7 cells. A preclinical model of MCF-7 xenografts was used to determine the influence of BC and DOX administration on tumor growth and metabolism. The number of apoptotic cells after...
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Pre-analytical aspects in metabolomics of human biofluids – sample collection, handling, transport, and storage
PublikacjaMetabolomics is the field of omics research that offers valuable insights into the complex composition of biological samples. It has found wide application in clinical diagnostics, disease investigation, therapy prediction, monitoring of treatment efficiency, drug discovery, or in-depth analysis of sample composition. A suitable study design constitutes the fundamental requirements to ensure robust and reliable results from the...
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Green Polymer Nanocomposites for Skin Tissue Engineering
PublikacjaFabrication of an appropriate skin scaffold needs to meet several standards related to the mechanical and biological properties. Fully natural/green scaffolds with acceptable biodegradability, biocompatibility, and physiological properties quite often suffer from poor mechanical properties. Therefore, for appropriate skin tissue engineering and to mimic the real functions, we need to use synthetic polymers and/or additives as complements...
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Towards Rational Biosurfactant Design—Predicting Solubilization in Rhamnolipid Solutions
PublikacjaThe efficiency of micellar solubilization is dictated inter alia by the properties of the solubilizate, the type of surfactant, and environmental conditions of the process. We, therefore, hypothesized that using the descriptors of the aforementioned features we can predict the solubilization efficiency, expressed as molar solubilization ratio (MSR). In other words, we aimed at creating a model to find the optimal surfactant and...
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Evaluating the antibacterial activity of muramyl dipeptide derivatives, retro-tuftsin derivatives, and anthraquinone oligopeptides against a range of pathogenic bacteria
PublikacjaSearch for new and efficient antibiotic is crucial because of microbial drug resistance and problems with side effects of the administered medication. In this study, we evaluate the in vitro microbiological activity of muramyl dipeptide derivatives, retro-tuftsin derivatives (i.e., tuftsin with reversed amino acid sequences), and combinations of retro-tuftsin derivatives with substituted anthraquinones. The potency of the investigated...
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Aggregation properties of some zirconium phosphate loaded with dirhenium(III) complexes
PublikacjaOne of the important areas of modern science is the selection of the right forms of drug delivery. Layered inorganic nanoparticles, such as zirconium phosphate, have proven themselves well in this area. The study of the properties of these systems and methods of their preparation makes it possible to determine a rational technology of their manufacture, storage conditions as well as suggest a possible mechanism of therapeutic action....
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Alternative treatment approaches of urinary tract infections caused by uropathogenic Escherichia coli strains
PublikacjaUrinary tract infections (UTIs) are the most widespread and annoying infections affecting millions of people every year annually. The biggest problem of urinary diseases are recurrences, the increasing resistance of uropathogens to commonly used antibiotics, as well as the high health care costs of afflicted persons. Uropathogenic Escherichia coli strains (UPECs) are the most dominant etiologic agent of community-acquired infections...
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Escherichia coli Strains with Virulent Factors Typical for Uropathogens were Isolated from Sinuses from Patients with Chronic Rhinosinusitis—Case Report
PublikacjaEscherichia coli were isolated from three patients with chronic rhinosinusitis (CRS) by intraoperative sinus tissue biopsy. Taking into account the unusual replicative niche and previous treatment failures, it was decided to focus on the virulence and drug resistance of these bacteria. The strains turned out to be multi-sensitive, but the rich virulence factors profile of bacteria typical for phylogenetic group B2 deserved attention....
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Przegląd technologii baz danych - stan obecny
PublikacjaW rozdziale przedstawiono sposoby klasyfikowania baz danych. Ponadto przeprowadzono ogólny przegląd dostępnych obecnie na rynku rozwiązań, z uwzględnieniem podziału na zastosowania małe i duże oraz na bazy komercyjne i bezpłatne. Powyższy przegląd pokazuje, że technologia baz danych stale się rozwija i próbuje dostosować do zmieniających się oczekiwań potencjalnych użytkowników. Kierunki rozwoju to coraz częstsze próby wykorzystania...
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Network on Chip implementation using FPGAs resources
PublikacjaW artykule przedstawiono implementację sieci typu ''Network on Chip'' w układach FPGA. Sieci typu ''Network on Chip'' stały się bardzo interesującym i obiecującym rozwiązaniem dla systemów typu ''System on Chip'' które charakteryzują się intensywną komunikacją wewnętrzną. Ze względu na inne paradygmaty projektowania nie ma obecnie dostępnych efektywnych platform do budowy prototypów sieci typu ''Network on Chip'' i ich weryfikacji....
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E-Learning Service Management System For Migration Towards Future Internet Architectures
PublikacjaAs access to knowledge and continuous learning are among the most valuable assets in modern, technological society, it is hardly surprising that e-learning solutions can be counted amongst the most important groups of services being deployed in modern network systems. Based on analysis of their current state-of-the-art, we decided to concentrate our research and development work on designing and implementing a management system...