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Novel Tools for Comprehensive Functional Analysis of LDLR (Low-Density Lipoprotein Receptor) Variants
PublikacjaFamilial hypercholesterolemia (FH) is an autosomal-dominant disorder caused mainly by substitutions in the low-density lipoprotein receptor (LDLR) gene, leading to an increased risk of premature cardiovascular diseases. Tremendous advances in sequencing techniques have resulted in the discovery of more than 3000 variants of the LDLR gene, but not all of them are clinically relevant. Therefore, functional studies of selected variants...
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Operational problems of constructed wetland for landfill leachates treatment: case study
PublikacjaIn the paper the quality fluctuations of leachate from municipal landfill in Gdansk (Poland) over the last 5 years and evaluation of a wetland system designed for treatment of the leachate are discussed.The research has been conducted during the 5 years period. The constructed wetland for leachate treatment, consisting of 2 horizontal subsurface flow reed beds, working in parallel was built in 2001. In the period 2005-06 it underwent...
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A Review: Structural Shape and Stress Control Techniques and their Applications
PublikacjaThis review article presents prior studies on controlling shape and stress in flexible structures. The study offers a comprehensive survey of literature concerning the adjustment and regulation of shape, stress, or both in structures and emphasizes such control’s importance. The control of systems is classified into three primary classes: nodal movement control, axial force control, and controlling the two classes concurrently....
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The methylome and transcriptome of fetal skin: implications for scarless healing
PublikacjaAim: Fetal skin is known to heal without scarring. In mice, the phenomenon is observed until the 16–17 day of gestation – the day of transition from scarless to normal healing. The study aims to identify key methylome and transcriptome changes following the transition. Materials & methods: Methylome and transcriptome profiles were analyzed in murine dorsal skin using microarray approach. Results & conclusion: The genes associated...
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Bridge Ergonomic Design: A Review
PublikacjaHuman error remains the most common cause of marine incidents and it is worth emphasizing that navigator’s performance is directly affected by ergonomic factors on the bridge. Studies regarding influence of bridge design and work environment on the operator are rare, thus the main purpose of this paper is to fill in this gap. Documents issued by recognized organizations, research publications and additional sources were reviewed...
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Influence of passive house technology on time and cost of construction investment
PublikacjaDue to the changes in the energy standards for housing in Poland there are many concerns. Is the standard required by the regulation achievable and if it is, then at what cost? There are many solutions to construct a building in line with the requirements of passive house technology. They are differentiated by price and time required for implementation. This study is based on the solution proposed by one of Polish companies, offering...
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Lessons learned in a decade: Medical‐toxicological view of tattooing
PublikacjaTattooing has been part of the human culture for thousands of years, yet only in the past decades has it entered the mainstream of the society. With the rise in popularity, tattoos also gained attention among researchers, with the aim to better understand the health risks posed by their application. 'A medical-toxicological view of tattooing'-a work published in The Lancet almost a decade ago, resulted from the international collaboration...
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Does the coordinated development of two-way FDI increase the green energy efficiency of Chinese cities? Evidence from Chinese listed companies
PublikacjaBased on the evidence from listed company microdata and data from 285 cities in China, this paper studies the coordinated development of two-way FDI (CDFDI) in improving green energy efficiency (GEE). In particular, this paper examines the spatial heterogeneity effects of CDFDI on GEE. The results showed that CDFDI had a positive impact on the GEE of local and surrounding cities. Mechanistic examinations show that the effects...
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Regulated assembly of lipopolysaccharide and sensing of its alterations in Escherichia coli
PublikacjaThis thesis describes mechanism of the regulation of the transcription of the rpoE gene encoding an essential RNA polymerase subunit in Escherichia coli. The RpoE regulates extracytoplasmic stress response regulon and is required to initiate transcription of genes, whose products are involvedin the folding of periplasmic proteins and synthesis and transport of outer membrane components. The transcriptional regulation of the rpoE...
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Elementary analysis and energetic potential of the sludge from the Gdynia Dębogórze and Lębork wastewater treatment plants
PublikacjaThe paper aims to show the results of the elementary analysis of the sewage sludges from wastewater treatment plants in Gdynia Dębogórze and Lębork as well as measurements of the heat of combustion and the calculated calorific values according to regulation PN-93/Z-15008, taking into account water content and the composition of sewage sludge at different utilisation stages. The results presented in this paper are based on the analysis...
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Influence of reactive oxygen species during deposition of iron oxide films by high power impulse magnetron sputtering.
PublikacjaIron oxide films were deposited using high power impulse magnetron sputtering (HiPIMS) of an iron cathode in an argon/oxygen gas mixture at different gas pressures (0.5~Pa, 1.5~Pa, and 5.0~Pa). The HiPIMS system was operated at a repetition frequency $f = 100$~Hz with a duty cycle of 1~\%. A main goal is a comparison of film growth during conventional and electron cyclotron wave resonance-assisted HiPIMS. The deposition plasma...
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Selected anionic and cationic surface active agents determined in river sediments – the Klodnica catchment
PublikacjaSurface active agents (SAAs) are specific compounds that contain hydrophilic/ hydrophobic group in their molecules named as amphiphilic structures. According to charge on the hydrophilic part of surfactants they can be classified into three main groups: anionic, cationic and non-ionic compounds. Due to the amphiphilic structure of SAAs they have specific properties (e.g. ability to adsorption at different surfaces, reduction of...
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HDAC Inhibitors: Innovative Strategies for Their Design and Applications
PublikacjaHistone deacetylases (HDACs) are a large family of epigenetic metalloenzymes that are involved in gene transcription and regulation, cell proliferation, differentiation, migration, and death, as well as angiogenesis. Particularly, disorders of the HDACs expression are linked to the development of many types of cancer and neurodegenerative diseases, making them interesting molecular targets for the design of new efficient drugs...
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Platforma edX - nowe podejście do kursów online
PublikacjaWspółczesne metody nauczania na odległość zmieniają się dynamicznie. Powstają światowe konsorcja podejmujące starania zapewnienia dostępu do edukacji na najwyższym poziomie z wykorzystaniem Internetu. Jedną z takich prób jest platforma edX. Jej rozwój zapoczątkowały niemal 2 lata temu MIT i Harvard. Obecnie zespół liczy już 30 uczelni z całego świata. Renoma ośrodków naukowych biorących udział w projekcie przyciągnęła już ponad...
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Deregulacja polskiego rynku pracy
PublikacjaHistorycznie ukształtowana regulacja rynku pracy związana jest z jego infrastrukturą organizacyjno-prawną, tzn. przepisami dotyczącymi płac, czasu pracy i ochrony stosunku pracy. W opinii zwolenników deregulacji utrudnia ona elastyczne dostosowywanie się do rozmiarów zatrudnienia w zależności od zaistniałej sytuacji gospodarczej, powodując wzrost bezrobocia strukturalnego i wzrost kosztów pracy. Deregulacja rynku pracy związana...
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UWARUNKOWANIA I SKUTKI ŻYWIOŁOWEJ SUBURBANIZACJI W POLSCE. CZY OPANOWANIE JEJ JEST MOŻLIWE?
PublikacjaArtykuł dotyczy procesu żywiołowej suburbanizcji (urban sprawl) w Polsce. Jego celami są: (1) analiza powiązań między negatywnymi skutkami tego procesu, (2) prezentacja negatywnych skutków dla transportu i zużycia energii oraz ładu przestrzennego, (3) analiza sposobów przeciwdziałania negatywnym procesom, w tym uwarunkowań (w szczególności ograniczeń) stosowania tych sposobów i ich skuteczności. Jako metody zastosowano: obserwację,...
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How do responsible universities perceive their social engagement? In search of signs of Creating Shared Value by the University
PublikacjaObjectives: University social responsibility still lacks legitimisation and is perceived as a burden that hinders academics from doing research and teaching. Creating Shared Value by the University may serve as a tool to motivate universities to engage in initiatives for society, as this is beneficial for both parties. Yet, some researchers perceive the creation of economic value as inappropriate for academia. Thus, it was interesting...
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Regulacja napięcia w sieci nN z rozproszonymi źródłami energii
PublikacjaPodłączanie rozproszonych źródeł energii do sieci energetycznych niskiego napięcia powoduje powstawanie problemów zmienności i niesymetrii napięcia, zwłaszcza w przypadku dużych odległości od transformatora zasilającego. W skrajnych przypadkach zachodzi konieczność redukcji mocy generowanej przez źródło podczas oddawaniu energii do sieci. Rozwiązaniem tego problemu jest zastosowanie energoelektronicznego regulatora napięcia składającego...
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Consequences of lysine auxotrophy for Candida albicans adherence and biofilm formation
PublikacjaA number of factors are known to be involved in Candida albicans virulence, although biofilm development on the surfaces of indwelling medical devices is considered to promote superficial or systemic disease. Based on previously reported up-regulation of saccharopine and acetyllysine in biofilm cells and activation of the lysine biosynthesis/degradation pathway, we investigated...
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New method to monitor changes in the subarachnoid width and pial artery pulsation for physiological and clinical research
PublikacjaThere are several medical conditions associated with brain oedema such as traumatic brain injury, intoxication or tumors. Brain edema and related brain parenchyma expansion may lead to compression and subsequent injury of several brain structures. So far, the only method enabling detection and monitoring of the progress a cerebral oedema in a patient, has been monitoring of intracranial pressure (ICP) with a pressure probe inserted...
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Experimental test results of an automatic voltage regulator with independent phase voltage controllers
PublikacjaThe growing number of distributed renewable energy sources and dynamic constant-power loads (e.g. electric vehicle charging stations) pose new challenges for network operators. These changes result in alterations to network load profiles and load flows, leading to greater voltage volatility. One effective solution to these problems can be the use of automatic voltage regulators (AVRs), which stabilize and symmetrize voltage output,...
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Genetic and Epigenetic Aspects of Atopic Dermatitis
PublikacjaAtopic dermatitis is a heterogeneous disease, in which the pathogenesis is associated with mutations in genes encoding epidermal structural proteins, barrier enzymes, and their inhibitors; the role of genes regulating innate and adaptive immune responses and environmental factors inducing the disease is also noted. Recent studies point to the key role of epigenetic changes in the development of the disease. Epigenetic modifications...
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Sequence-dependent structural properties of B-DNA: what have we learned in 40 years?
PublikacjaThe structure of B-DNA, the physiological form of the DNA molecule, has been a central topic in biology, chemistry and physics. Far from uniform and rigid, the double helix was revealed as a flexible and structurally polymorphic molecule. Conformational changes that lead to local and global changes in the helix geometry are mediated by a complex choreography of base and backbone rearrangements affecting the ability of the B-DNA...
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cDNA fingerprint from the hepatopancreatic glands of pond snails (Lymnaea stagnalis) exposed to benzo[a]pyrene
PublikacjaIdentification of differentially expressed genes that could be potentially used as biomarkers of PAH exposure of common invertebrate animal (like freshwater snail) would be a valuable resource for investigators interested in toxicology and biomonitoring of aquatic environments. Therefore, the aim of this research was to investigate effects of waterborne benzo[a]pyrene (B[a]P) exposure on mRNA expression in the pond snail’s (Lymnaea...
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Sequence variants of p21 gene of the MRL/MpJ mouse: a possible association with the deficit of p21 protein and regenerative phenotype.
PublikacjaThe MRL/MpJ mouse is known for its enhanced regeneration abilities that manifested themselves by scarless ear-hole wound closure. The deficit of p21 found in the MRL is associated with the regenerative capacity as the p21 gene knockout in a mouse strain unrelated to the MRL mouse results in an ear-hole closure effect, similar to that observed in the MRL mouse. Cdkn1a gene encodes p21 protein, a cyclin-dependent kinase inhibitor,...
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Corporate social responsibility in reference to environmental statements within EMAS system in small and medium enterprises
PublikacjaAccording to the corporate social responsibility concept, organisations should apply any mechanisms available supporting their business actions contributing i.e. to the improvement of natural environment. Among them is EMAS eco-management and audit scheme. The prove of its implementation is environmental statement and entering the organisation into a national EMAS register. The aim of the statement is informing the society and...
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Visualization of short-term heart period variability with network tools as a method for quantifying autonomic drive
PublikacjaWe argue that network methods are successful in detecting nonlinear properties in the dynamics of autonomic nocturnal regulation in short-term variability. Two modes of visualization of networks constructed from RR-increments are proposed. The first is based on the handling of a state space. The state space of RR-increments can be modified by a bin size used to code a signal and by the role of a given vertex as the representation...
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Why Are Left-Handed G-Quadruplexes Scarce?
PublikacjaG-quadruplexes (G4s) are nucleic acid structures crucial for the regulation of gene expression and genome maintenance. While they hold promise as nanodevice components, achieving desired G4 folds requires understanding the interplay between stability and structural properties, like helicity. Although right-handed G4 structures dominate the experimental data, the molecular basis for this preference over left-handed helicity is unclear....
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Utilizing Genome-Wide mRNA Profiling to Identify the Cytotoxic Chemotherapeutic Mechanism of Triazoloacridone C-1305 as Direct Microtubule Stabilization
PublikacjaRational drug design and in vitro pharmacology profiling constitute the gold standard in drug development pipelines. Problems arise, however, because this process is often dicult due to limited information regarding the complete identification of a molecule’s biological activities. The increasing aordability of genome-wide next-generation technologies now provides an excellent opportunity to understand a compound’s diverse eects...
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The Association Between Religion and Healthcare Professionals’ Attitudes Towards the Conscience Clause. A Preliminary Study From Poland
PublikacjaObjectives: This study was designed to determine the relationship between religion and healthcare practitioners’ attitudes towards conscience clauses in Poland.Methods: We developed a survey assessing impact of religion on attitudes healthcare professionals towards the conscience clause. These questions were explored using a sample of 300 Polish healthcare professionals.Results: The results indicate that religiosity...
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Personal branding of artists and art-designers: necessity or desire?
PublikacjaPurpose Personal branding becomes a new in-demand skill for all professionals today. To be well-known helps to achieve success in the networked business environment. Personal relationships and a good reputation in the reality of network economy help young artists and art designers move up the career ladder. This paper aims to discuss a problem of artists who often find it difficult to define their artistic and self-distinction...
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Effect of nitrogen doping on TiOxNy thin film formation at reactive high-power pulsed magnetron sputtering
PublikacjaThe paper is focused on a study of formation of TiOxNy thin films prepared by pulsed magnetron sputtering of metallic Ti target. Oxygen and nitrogen were delivered into the discharge in the form of reactive gases O2 and N2. The films were deposited by high-power impulse magnetron sputtering working with discharge repetition frequency f = 250 Hz at low (p = 0.75 Pa) and high (p = 10 Pa) pressure. The substrates were on floating...
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Small regulatory bacterial RNAs regulating the envelope stress response
PublikacjaMost bacteria encode a large repertoire of RNA-based regulatory mechanisms. Recent discoveries have revealed that the expression of many genes is controlled by a plethora of base-pairing noncoding small regulatory RNAs (sRNAs), regulatory RNA-binding proteins and RNA-degrading enzymes. Some of these RNA-based regulated processes respond to stress conditions and are involved in the maintenance of cellular homeostasis. They achieve...
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Molecular dynamics simulations reveal the balance of forces governing the formation of a guanine tetrad—a common structural unit of G-quadruplex DNA
PublikacjaG-quadruplexes (G4) are nucleic acid conformations of guanine-rich sequences, in which guanines are arranged in the square-planar G-tetrads, stacked on one another. G4 motifs form in vivo and are implicated in regulation of such processes as gene expression and chromosome maintenance. The structure and stability of various G4 topologies were determined experimentally; however, the driving forces for their formation are not fully...
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Two-photon microperimetry with picosecond pulses
PublikacjaTwo-photon vision is a phenomenon associated with the perception of short pulsesof near-infrared radiation (900-1200 nm) as a visible light. It is caused by the nonlinear processof two-photon absorption by visual pigments. Here we present results showing the influence ofpulse duration and repetition rate of short pulsed lasers on the visual threshold. We comparedtwo-photon sensitivity maps of the retina obtained for subjects with...
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WORK MOTIVATION PROFILES AND WORK PERFORMANCE IN A GROUP OF CORPORATE EMPLOYEES: A TWO-STEP CLUSTER ANALYSIS
PublikacjaFew studies have applied a person-centered approach to work motivation using cluster or profile analyses. Thus, little is known about which configurations of work motivations characterize professionals. The aim of this study is to establish the structure of work motivation profiles under the framework of self-determination theory and to examine the relationship between work motivation and subjective work performance. The study...
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Endothelial Dysfunction Driven by Hypoxia—The Influence of Oxygen Deficiency on NO Bioavailability
PublikacjaCardiovascular diseases (CVDs) are the leading cause of death worldwide. The initial stage of CVDs is characterized by endothelial dysfunction, defined as the limited bioavailability of nitric oxide (NO). Thus, any factors that interfere with the synthesis or metabolism of NO in endothelial cells are involved in CVD pathogenesis. It is well established that hypoxia is both the triggering factor as well as the accompanying factor...
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Mind the Gender Wage Gap – the Impact of Trade and Competition on Sectoral Wage Difference
PublikacjaThis article examines differences between women’s and men’s wages in 18 selected OECD countries in the period 1970-2005. The study is based on 12 manufacturing sector- and skill-specific sets of panel data on the gender wage gap. We apply a system GMM estimator to the extended version of the conditional gender wage gap convergence equation, controlling for sector concentration and industry-specific measures of openness using a...
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Preparation and characterization of TiO2 nanostructures for catalytic CO2 photoconversion
PublikacjaThe titanium dioxide target (99.7%) of 1 cm in dia was ablated in vacuum by laser pulses(6 ns) at 266 nm and at repetition rate of 10 Hz. During deposition the laser fluence between 1 and 3.5 J/cm2 and the O2 pressure from the range of 10-2 - 1 Pa were applied. The thin TiO2 films were deposited on glass substrate (1 × 1 cm2) heated up to 500 °C. The chemical composition of the film and samples produced by annealing were investigated...
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Entropic Measures of Complexity of Short-Term Dynamics of Nocturnal Heartbeats in an Aging Population
PublikacjaTwo entropy-based approaches are investigated to study patterns describing differences in time intervals between consecutive heartbeats. The first method explores matrices arising from networks of transitions constructed following events represented by a time series. The second method considers distributions of ordinal patterns of length three, whereby patterns with repeated values are counted as different patterns. Both methods provide...
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Porównanie efektywności biologicznego usuwania związków biogennych w procesach MUCT i A2/O na przykładzie oczyszczalni w Gdańsku
PublikacjaThis paper presents a comparison of the efficiency of nutrient removal in two different technological systems functioning in WWTP in Gdansk. The upgrade was necessary in order to adjust the parameters of wastewater treatment to more stringent requirements for Total Nitrogen removal (Total Nitrogen concentration < 10 mg/L). Since 2012 the biological treatment line has operated based on modified A2/O process instead of MUCT process....
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The Unfolded Protein Response: A Double-Edged Sword for Brain Health
PublikacjaEfficient brain function requires as much as 20% of the total oxygen intake to support normal neuronal cell function. This level of oxygen usage, however, leads to the generation of free radicals, and thus can lead to oxidative stress and potentially to age-related cognitive decay and even neurodegenerative diseases. The regulation of this system requires a complex monitoring network to maintain proper oxygen homeostasis. Furthermore,...
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Modular Approach for Modelling Warming Up Process in Water Installations with Flow-Regulating Elements
PublikacjaThe paper presents a new method for modelling the warming up process of a water system with elements regulating the flow in a stochastic manner. The paper presents the basic equations describing the work of typical elements which the water installation is composed of. In the proposed method, a new computational algorithm was used in the form of an iterative procedure enabling the use of boundary conditions that can be stochastically...
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DNA methylation as a mediator of HLA-DRB1*15:01 and a protective variant in multiple sclerosis
PublikacjaThe human leukocyte antigen (HLA) haplotype DRB1*15:01 is the major risk factor for multiple sclerosis (MS). Here, we find that DRB1*15:01 is hypomethylated and predominantly expressed in monocytes among carriers of DRB1*15:01. A differentially methylated region (DMR) encompassing HLA-DRB1 exon 2 is particularly affected and displays methylation-sensitive regulatory properties in vitro. Causal inference and Mendelian randomization...
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A Data Driven Model for Predicting RNA-Protein Interactions based on Gradient Boosting Machine
PublikacjaRNA protein interactions (RPI) play a pivotal role in the regulation of various biological processes. Experimental validation of RPI has been time-consuming, paving the way for computational prediction methods. The major limiting factor of these methods has been the accuracy and confidence of the predictions, and our in-house experiments show that they fail to accurately predict RPI involving short RNA sequences such as TERRA RNA....
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Nitric Oxide-Dependent Pathways as Critical Factors in the Consequences and Recovery after Brain Ischemic Hypoxia
PublikacjaBrain ischemia is one of the leading causes of disability and mortality worldwide. Nitric oxide (NO), a molecule that is involved in the regulation of proper blood flow, vasodilation, neuronal and glial activity constitutes the crucial factor that contributes to the development of pathological changes after stroke. One of the early consequences of a sudden interruption in the cerebral blood flow is the massive production of reactive...
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Chemical Aspects of Biological Activity of Isothiocyanates and Indoles, the Products of Glucosinolate Decomposition
PublikacjaThere is growing evidence that cancer chemoprevention employing natural, bioactive compounds may halt or at least slow down the different stages of carcinogenesis. A particularly advantageous effect is attributed to derivatives of sulfur-organic phytochemicals, such as glucosinolates (GLs) synthesized mainly in Brassicaceae plant family. GLs are hydrolysed enzymatically to bioactive isothiocyanates (ITC) and indoles, which exhibit strong...
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ABSORPCJA, METABOLIZM I ROLA BIOLOGICZNA KWASÓW NUKLEINOWYCH OBECNYCH W ŻYWNOŚCI
PublikacjaKwasy nukleinowe należą do niedocenianych składników żywności, szczególnie surowej lub nisko przetworzonej. W niniejszej publikacji skupiono się na omówieniu przemian, jakim podlegają kwasy nukleinowe w przewodzie pokarmowym człowieka, procesie absorpcji nukleotydów oraz nukleozydów z przewodu pokarmowego, a także przedstawiono podstawowe etapy ich metabolizmu w komórkach organizmu. Produkty trawienia kwasów nukleinowych stanowią...
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SiMiSnoRNA: Collection of siRNA, miRNA, and snoRNA database for RNA Interference
PublikacjaObjective:The discovery of sequence specific gene silencing which occurs due to the presence of double-stranded RNAs has considerable impact on biology, revealing an unknown level of regulation of gene expression. This process is known as RNA interference (RNAi) or RNA silencing in which RNA molecules inhibit gene expression, typically by causing the destruction of specific mRNA molecule. Two types of small RNA molecules - small...
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Budesonide treatment of professional athletes and anti-doping testing- case studies
PublikacjaAccording to the World Anti-Doping Agency (WADA) Prohibited List, glucocorticosteroids are prohibited in competition and only when administered by oral, intravenous, intramuscular or rectal routes. Up to now, in order to differentiate whether glucocorticosteroids were administered by one of the prohibited routes or not, a specific reporting limit for urinary concentrations of parent compounds and their metabolites was established...