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Genetic and pharmacologic proteasome augmentation ameliorates Alzheimer’s-like pathology in mouse and fly APP overexpression models
PublikacjaThe proteasome has key roles in neuronal proteostasis, including the removal of misfolded and oxidized proteins, presynaptic protein turnover, and synaptic efficacy and plasticity. Proteasome dysfunction is a prominent feature of Alzheimer’s disease (AD). We show that prevention of proteasome dysfunction by genetic manipulation delays mortality, cell death, and cognitive deficits in fly and cell culture AD models. We developed...
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Molecular characterization of drug-resistant Mycobacterium tuberculosis strains from Poland by use of multiple genetic markers
PublikacjaW pracy przedstawiono wyniki genotypowania wielolekoopornych szczepów Mycobacterium tuberculosis, izolowanych od pacjentów z Polski.
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Genetic inactivation and chemical inhibition of PARP-1 lead to increased cytotoxicity to antitumor triazoloacridone C-1305
PublikacjaOkreśliliśmy aktywność cytotoksyczną związku C-1305 wobec komórek z obniżoną aktywnością PARP-1 w wyniku działania inhibitora tego enzymu związku NU1025. Dane wskazują, że w zależności od rodzaju inhibitora topoizomerazy II obniżenie aktywności PARP-1 przez związek NU1025 prowadzi do zwiększenia bądź obniżenia cytotoksyczności tych leków. Działanie NU1025 prowadzi również do re-aktywacji szlaku p53 w komórkach HeLa, czego jak dotąd...
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Hierarchical Estimation of Human Upper Body Based on 2D Observation Utilizing Evolutionary Programming and 'Genetic Memory'
PublikacjaNew method of the human body pose estimation based on single camera 2D observation is presented. It employs 3D model of the human body, and genetic algorithm combined with annealed particle filter for searching the global optimum of model state, best matching the object's 2D observation. Additionally, motion cost metric is employed, considering current pose and history of the body movement, favouring the estimates with the lowest...
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Genetic heterogeneity in primary and relapsed mantle cell lymphomas: Impact of recurrent <i>CARD11</i> mutations
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Genetic response to metabolic fluctuations: correlation between central carbon metabolism and DNA replication in Escherichia coli
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Quantitative Analysis of Biofilm Formed on Vascular Prostheses by Staphylococcus Epidermidis with Different ica and aap Genetic Status
PublikacjaOBJECTIVES: This study aims to examine biofilm formed on vascular prostheses by Staphylococcus epidermidis with different ica and aap genetic status, and to evaluate the effect of antibiotic-modified prostheses on bacterial colonization. METHODS: Biofilm formation was determined using fluorescence microscopy imaging. Quantitative analysis was conducted using the biofilm coverage ratio (BCR) calculations. RESULTS: Our investigations...
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Genetic and pharmacologic proteasome augmentation ameliorates Alzheimer’s-like pathology in mouse and fly APP overexpression models
PublikacjaThe proteasome has key roles in neuronal proteostasis, including the removal of misfolded and oxidized proteins, presynaptic protein turnover, and synaptic efficacy and plasticity. Proteasome dysfunction is a prominent feature of Alzheimer’s disease (AD). We show that prevention of proteasome dysfunction by genetic manipulation delays mortality, cell death, and cognitive deficits in fly and cell culture AD models. We developed...
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Distant Analysis of the GENEPI-ENTB Databank – System Overview
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The effects of resistance training experience on movement characteristics in the bench press exercise
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Real and Virtual Instruments in Machine Learning – Training and Comparison of Classification Results
PublikacjaThe continuous growth of the computing power of processors, as well as the fact that computational clusters can be created from combined machines, allows for increasing the complexity of algorithms that can be trained. The process, however, requires expanding the basis of the training sets. One of the main obstacles in music classification is the lack of high-quality, real-life recording database for every instrument with a variety...
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Deep Learning Optimization for Edge Devices: Analysis of Training Quantization Parameters
PublikacjaThis paper focuses on convolution neural network quantization problem. The quantization has a distinct stage of data conversion from floating-point into integer-point numbers. In general, the process of quantization is associated with the reduction of the matrix dimension via limited precision of the numbers. However, the training and inference stages of deep learning neural network are limited by the space of the memory and a...
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Exploration of Creativity Techniques in Software Engineering in Training-Application-Feedback Cycle
PublikacjaCreativity research has proposed about a hundred and fifty creativity techniques. The question is whether they can be applied in software engineering for creativity training or directing creativity in software projects. This paper aims at answering this question via a quasi-experiment conducted in Training-Application-Feedback cycle in which participants express their opinions about selected creativity techniques after training...
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Moving Towards Competence in Teaching Architecture: The Relationship of Research and Design in Academia
PublikacjaArchitecture is truly a profession of public trust requiring special care at all stages in academic education. European educational reforms initiated by the 1999 Bologna Process affected architecture education, and shifted the role of research. The number of doctoral programs increased, so the involvement of PhD students in teaching also expanded. This study aims to identify how these changes affect quality in architecture education....
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Multimedia polysensory integration training system dedicated to children with educational difficulties
PublikacjaThis paper aims at presenting a multimedia system providing polysensory train- ing for pupils with educational difficulties. The particularly interesting aspect of the system lies in the sonic interaction with image projection in which sounds generated lead to stim- ulation of a particular part of the human brain. The system architecture, video processing methods, therapeutic exercises and guidelines for children’s interaction...
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Soliton trapping and orthogonal Raman scattering in a birefringent photonic crystal fiber
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Effects of Base π-Stacking on Damage to DNA by Low-Energy Electrons
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Resistance Training with Blood Flow Restriction and Ocular Health: A Brief Review
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Workstation for training asw helicopter navigators and analysis real flight data
PublikacjaW artykule opisane zostało stanowisko szkoleniowo-diagnostyczne i analizy danych skonstruowane z przeznaczeniem dla nawigatorów śmigłowców ASW eksploatowanych w polskiej Marynarce Wojennej i zainstalowane w bazie śmigłowców. Umożliwia ono prowadzanie szkoleń i treningów w zakresie eksploatacji oraz wykonywanie analiz informacji zebranych przez nawigatorów podczas lotów z pokładowego sonaru ASW, odbiornika sygnałów z sonoboi i...
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Stacking and rotation-based technique for machine learning classification with data reduction
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Training Services in Small and Medium-sized Enterprises: Evidence from Poland
PublikacjaIn the knowledge-based economy knowledge and skills are becoming more and more significant for the success of companies. This applies also to firms from small and medium-sized enterprises (SMEs) sector. As large companies in many cases posses special divisions devoted to trainings, they normally have no problems with updating the knowledge and skills of their employees. The situation is different with regard to SMEs, which often...
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Teaching High Performance Computing Using BeesyCluster and Relevant Usage Statistics
PublikacjaThe paper presents motivations and experiences from using the BeesyCluster middleware for teaching high performance computing at the Faculty of Electronics, Telecommunications and Informatics, Gdansk University of Technology. Features of BeesyCluster well suited for conducting courses are discussed including: easy-to-use WWW interface for application development and running hiding queuing systems, publishing applications as services...
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Interactive Prototypes in Teaching User-Centred Design and Business Process Modelling
PublikacjaThis publication describes experiences gathered during the use of interactive prototyping in two areas: design of user interfaces for a touch screen information kiosk and interactive prototyping of business processes. Prototyping is promoted here as a technique useful for both visualizing design concepts and for stimulating communication within relevant teams. Developing interactive prototypes of use interfaces is discussed here...
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Modular machine learning system for training object detection algorithms on a supercomputer
PublikacjaW pracy zaprezentowano architekturę systemu służącego do tworzenia algorytmów wykorzystujących metodę AdaBoost i służących do wykrywania obiektów (np. twarzy) na obrazach. System został podzielony na wyspecjalizowane moduły w celu umożliwienia łatwej rozbudowy i efektywnego zrównoleglenia implementacji przeznaczonej dla superkomputera. Na przykład, system może być rozszerzony o nowe cechy i algorytmy ich ekstrakcji bez konieczności...
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Migration time shift of analytes in micellar electrokinetic chromatography induced by stacking
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Podejście środowiskowe w dydaktyce projektowania Sustainable approach in teaching of design
PublikacjaThe aim of the paper is to assess the inclusion of academic teaching design to the process of sustainable development and proposals for an integrated approach in training architects. The article presents an original interpretation of environmental design in the field of architecture and urban planning. The significance of the environmental perspective is presented in the context of growing spatial and social fragmentation. The...
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Surface and Trapping Energies as Predictors for the Photocatalytic Degradation of Aromatic Organic Pollutants
PublikacjaIn this study, anatase samples enclosed by the majority of three different crystal facets {0 0 1}, {1 0 0}, and {1 0 1} were successfully synthesized. These materials were further studied toward photocatalytic degradation of phenol and toluene as model organic pollutants in water and gas phases. The obtained results were analyzed concerning their surface structure, reaction type, and surface development. Moreover, the regression...
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Vehicle Detection with Self-Training for Adaptative Video Processing Embedded Platform
PublikacjaTraffic monitoring from closed-circuit television (CCTV) cameras on embedded systems is the subject of the performed experiments. Solving this problem encounters difficulties related to the hardware limitations, and possible camera placement in various positions which affects the system performance. To satisfy the hardware requirements, vehicle detection is performed using a lightweight Convolutional Neural Network (CNN), named...
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Piotr Jaskuła dr hab. inż.
OsobyI am a Faculty member (Associate Professor, Highway and Transportation Research Department) at the Faculty of Civil and Environmental Engineering, Gdansk University of Technology, Poland).My main research interests include: pavement structures, interlayer bonding, pavement materials, recycling of road pavements, asphalt mixtures, bitumens, construction and maintenance of pavement structures.My lectures at the University include:...
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Frontiers in Genetics
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New possibilities of the passive layer cracking dynamics detection using a new Dynamic Electrochemical Impedance Spectroscopy.
PublikacjaNowa metoda Dynamicznej Elektrochemicznej Spektroskopii Impedancyjnej opracowana w Katedrze Elektrochemii, Korozji i Inżynierii Materiałowej Politechniki Gdańskiej daje możliwości określania charakterystyki impedancyjnej w dziedzinie czasu podczas procesu pękania ochronnej warstwy pasywnej. Fakt ten jest związany z procedurą analizującą wspomnianej techniki, która umożliwia selektywną analizę czasowo-częstotliwościową uzyskanych...
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Simulations of hydro-fracking in rock mass at meso-scale using fully coupled DEM/CFD approach
PublikacjaThe paper deals with two-dimensional (2D) numerical modelling of hydro-fracking (hydraulic fracturing) in rocks at the meso-scale. A numerical model was developed to characterize the properties of fluid-driven fractures in rocks by combining the discrete element method (DEM) with computational fluid dynamics (CFD). The mechanical behaviour of the rock matrix was simulated with DEM and the behaviour of the fracturing fluid flow...
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A Family of Pb-based Superconductors with Variable Cubic to Hexagonal Packing
PublikacjaWe describe three previously unreported superconductors, BaPb3, Ba0.89Sr0.11Pb3, and Ba0.5Sr0.5Pb3. These three materials, together with SrPb3, form a distinctive isoelectronic family of intermetallic superconductors based on the stacking of Pb planes, with crystal structures that display a hexagonal to cubic perovskite-like progression, as rarely seen in metals. The superconducting transition temperatures (Tc) are similar for...
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Ranking metrics in gene set enrichment analysis: do they matter?
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An algorithm to generate high dense packing of particles with various shapes
PublikacjaDiscrete Element Method (DEM) is one of available numerical methods to compute movement of particles in large scale simulations. The method has been frequently applied to simulate the cases of grain or bulk material as the major research issue. The paper describes a new method of generating high dense packing with mixed material of two different shape used in DEM simulation. The initial packing is an important parameter to control,...
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Packing Three-Vertex Paths in 2-Connected Cubic Graphs
PublikacjaW pracy rozważano problem rozmieszczanie ścieżek P3 w 2-spójnych grafach 3-regularnych. Pokazano, że w 2-spójnym grafie 3-regularnym o n wierzchołkach można zawsze pokryć 9/11 n wierzchołków przez ścieżki P3; podano także odpowiednie oszacowania górne.
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Bin-packing based optimisation of EON Networks with S-BVTs
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Ranking ecosystem services delivered by trees in urban and rural areas
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Are Pair Trading Strategies Profitable During COVID-19 Period?
PublikacjaPair trading strategy is a well-known profitable strategy in stock, forex, and commodity markets. As most of the world stock markets declined during COVID-19 period, therefore this study is going to observe whether this strategy is still profitable after COVID-19 pandemic. One of the powerful algorithms of DBSCAN under the umbrella of unsupervised machine learning is applied and three clusters were formed by using market and accounting...
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ortho-Fluorobenzanilides and ortho-fluorothiobenzanilides: Molecular conformations and crystal packing
PublikacjaSeries of 2-fluoro and 2,6-difluorobenzanilides and their thiobenzanilide analogs have been synthesized to investigate the influence of the fluorine atom on their crystal structures and self-assembly in the crystal lattice. The X-ray analysis of the single crystal revealed that the synthesized molecules adopt a geometry being deflected from planarity. The deflection was investigated by analysis of dihedral angles between mean planes...
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Stabilizing forces in trapezoidal sheeting used as a part of the bracing system
PublikacjaIn the analysis of bracing systems imperfections of the restrained elements should be considered. According to EC3 this effect can be calculated by means of the equivalent stabilizing force, which replaces (in simplified way) initial bow imperfection of the braced element. However, alternative suggestions of the equivalent stabilizing force calculations can be also found in the literature. In this paper segment of the pitched roof...
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Stabilizing forces in trapezoidal sheeting used as a part of the bracing system
PublikacjaIn the analysis of bracing systems imperfections of the restrained elements should be considered. According to EC3 this effect can be calculated by means of the equivalent stabilizing force, which replaces (in simplified way) initial bow imperfection of the braced element. However, alternative suggestions of the equivalent stabilizing force calculations can be also found in the literature. In this paper segment of the pitched roof...
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Ranking ecosystem services delivered by trees in urban and rural areas
PublikacjaPolicies and strategies for tree management and protection on a national, regional, and local level have not sufficiently considered differences between rural and urban areas. We used expert knowledge to compare rural and urban areas in a case study evaluating the relative importance of ecosystem services (ES) in policy development. The Analytic Hierarchy Process (AHP) and focus group discussions were used to rank 17 ES, representing...
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Ranking of Generation Source Locations by a Hybrid Multi-Criteria Method
PublikacjaThe paper presents a ranking of the locations of eight renewable energy sources (RES) made using a hybrid multi-criteria analysis method. The method is a combination of the analytical hierarchical process (AHP) method and numerical taxonomy. The considered generating sources, i.e. solar plants, biogas plants, and wind farms are sources that will significantly contribute to implementing the provisions of the energy and climate package...
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Reduced attention toward faces, intentionality and blame ascription in violent offenders and community‐based adults: Evidence from an eye‐tracking study
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Automatic Identification System (AIS) Dynamic Data Integrity Monitoring and Trajectory Tracking Based on the Simultaneous Localization and Mapping (SLAM) Process Model
PublikacjaTo enhance the safety of marine navigation, one needs to consider the involvement of the automatic identification system (AIS), an existing system designed for ship-to-ship and shipto- shore communication. Previous research on the quality of AIS parameters revealed problems that the system experiences with sensor data exchange. In coastal areas, littoral AIS does not meet the expectations of operational continuity and system availability,...
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General concept of reduction process for big data obtained by interferometric methods
PublikacjaInterferometric sonar systems apply the phase content of the sonar signal to measure the angle of a wave front returned from the seafloor or from a target. It collect a big data – datasets that are so large or complex that traditional data processing application software is inadequate to deal with them. The recording a large number of data is associated with the difficulty of their efficient use. So data have to be reduced. The main...
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First recurrent large genomic rearrangement in the BRCA1 gene found in Poland
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SDN testbed for validation of cross-layer data-centric security policies
PublikacjaSoftware-defined networks offer a promising framework for the implementation of cross-layer data-centric security policies in military systems. An important aspect of the design process for such advanced security solutions is the thorough experimental assessment and validation of proposed technical concepts prior to their deployment in operational military systems. In this paper, we describe an OpenFlow-based testbed, which was...
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Heteroclinic solutions of Allen-Cahn type equations with a general elliptic operator
PublikacjaWe consider a generalization of the Allen-Cahn type equation in divergence form $-\rm{div}(\nabla G(\nabla u(x,y)))+F_u(x,y,u(x,y))=0$. This is more general than the usual Laplace operator. We prove the existence and regularity of heteroclinic solutions under standard ellipticity and $m$-growth conditions.