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Search results for: 1-BUTYL-4-METHYLPYRIDINIUM
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Influence of dissolved organic nitrogen on surface waters
PublicationThe aim of this study was to determine the susceptibility of dissolved organic nitrogen (DON) contained in biologically treated wastewater disposed from municipal wastewater treatment plants (WWTPs) to biodegradability and bioavailability in a water environment. Additionally an evaluation was performed of the participation of this organic nitrogen fraction, including bioavailable DON (bDON), in the nitrogen balance for the Baltic...
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Novel 2-alkythio-4-chloro-N-[imino(heteroaryl)methyl]benzenesulfonamide Derivatives: Synthesis, Molecular Structure, Anticancer Activity and Metabolic Stability
PublicationA series of novel 2-alkythio-4-chloro-N-[imino-(heteroaryl)methyl]benzenesulfonamide derivatives, 8–24, were synthesized in the reaction of the N-(benzenesulfonyl)cyanamide potassium salts 1–7 with the appropriate mercaptoheterocycles. All the synthesized compounds were evaluated for their anticancer activity in HeLa, HCT-116 and MCF-7 cell lines. The most promising compounds, 11–13, molecular hybrids containing benzenesulfonamide...
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Gender Disparity in the FinTech Sector: Systematic Literature Review
PublicationThe main objective of this chapter is to identify research areas of FinTech activity in which gender disparity has been observed. In addition, we shall identify how the development of FinTech reduces the gender gap. A systematic literature review using the PRISMA concept is the preferred research method. Publications were searched in the following databases: Web of Science, Scopus and Google Scholar using the formula “FinTech AND...
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Concept of an Innovative System for Dimensioning and Predicting Changes in the Coastal Zone Topography Using UAVs and USVs (4DBatMap System)
PublicationThis publication is aimed at developing a concept of an innovative system for dimensioning and predicting changes in the coastal zone topography using Unmanned Aerial Vehicles (UAVs) and Unmanned Surface Vehicles (USVs). The 4DBatMap system will consist of four components: 1. Measurement data acquisition module. Bathymetric and photogrammetric measurements will be carried out with a specific frequency in the coastal zone using...
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Application of Feed Forward Neural Networks for Modeling of Heat Transfer Coefficient During Flow Condensation for Low and High Values of Saturation Temperatur
PublicationMost of the literature models for condensation heat transfer prediction are based on specific experimental parameters and are not general in nature for applications to fluids and non-experimental thermodynamic conditions. Nearly all correlations are created to predict data in normal HVAC conditions below 40°C. High temperature heat pumps operate at much higher parameters. This paper aims to create a general model for the calculation...
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Numerical simulation of cold flow and combustion in a swirl stabilized combustor
PublicationA numerical simulation model was developed to investigate the cold flow and combustion using Ansys FLUENT 2021R1. The governing equations were solved using the pressure-based method, and pressure–velocity coupling was performed using the SIMPLE method. To model the turbulent process, the RSM model was used. Non-premixed model is chosen to solve the chemical kinetics between fuel and oxigen. Radiation heat transfer was calculated...
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Conception and design of a hybrid exciter for brushless synchronous generator. Application for autonomous electrical power systems = Koncepcja i projekt hybrydowej wzbudnicy bezszczotkowego generatora synchronicznego. Zastosowanie w autonomicznych systemach elektroenergetycznych
PublicationIn this paper a hybrid excitation system for a brushless synchronous generator working with variable speed in an autonomous energy generation system (e.g. airplane power grid) has been presented. A conception of a dual-stator hybrid exciter has been proposed. Comparison study of classical and hybrid exciter has been carried out. For the electromagnetic calculation two approaches have been applied: an analytical approach (based...
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Analiza podatności na rozkład biologiczny odcieków składowiskowych oczyszczanych w wielostopniowym systemie hydrofitowym
PublicationW skład materii organicznej ścieków, i odcieków ze składowisk odpadów wchodzą z różnorodne związki organiczne, które charakteryzują się różną podatnością na rozkład biologiczny. Charakterystykę ilościową umożliwia oznaczanie tzw. frakcji ChZT. Rozróżnia się 4 frakcje: frakcję rozpuszczoną rozkładalną na drodze biologicznej (SS), frakcję zawiesinową rozkładalną na drodze biologicznej (XS), frakcję rozpuszczoną nierozkładalną biologicznie...
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Rapid and simple multi-analyte LC–MS/MS method for the determination of benzodiazepines and Z-hypnotic drugs in blood samples: Development, validation and application based on three years of toxicological analyses
PublicationBenzodiazepines (BZDs) and Z-drugs have been particularly important treatments for sleeping and anxiety disorders for many years. However, recently, a number of new benzodiazepines (named designer benzodiazepines, DBZDs) were synthesised, but some of them have never been used in the clinic; they reached the black drug market as new psychoactive substances and are used for recreational purposes. The abuse of these substances has...
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Microstructure and mechanical properties of a dissimilar metal welded joint of Inconel 617 and P92 steel with Inconel 82 buttering layer for AUSC boiler application
PublicationThe application of the novel dissimilar metal welded (DMW) joint, utilizing Inconel 617 and P92 steel, was showcased in the advanced ultra-supercritical (AUSC) boiler. The work has been performed to investigate the effect of Inconel 82 (ERNiCr-3) buttering layer on microstructure and mechanical properties (high-temperature tensile strength, impact strength and microhardness) of gas tungsten arc welded (GTAW) dissimilar joint between...
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DIAGNOSTIC INFORMATION ANALYSIS OF QUICKLY CHANGING TEMPERATURE OF EXHAUST GAS FROM MARINE DIESEL ENGINE PART I SINGLE FACTOR ANALYSIS
PublicationIn this paper, attention was paid to the problem of low controllability of marine medium- and high-speed engines during operation, which significantly limits the parametric diagnosis. The measurement of quickly changing temperature of engine exhaust gas was proposed, the courses of which can be a source of diagnostic information. The F statistic of the Fisher-Snedecor distribution was chosen as a statistical tool. Laboratory tests...
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The coexistence and competition of canonical and comammox nitrite oxidizing bacteria in a nitrifying activated sludge system – Experimental observations and simulation studies
PublicationThe second step of nitrification can be mediated by nitrite oxidizing bacteria (NOB), i.e. Nitrospira and Nitrobacter, with different characteristics in terms of the r/K theory. In this study, an activated sludge model was developed to account for competition between two groups of canonical NOB and comammox bacteria. Heterotrophic denitrification on soluble microbial products was also incorporated into the model. Four 5-week washout...
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Real-time monitoring of volatiles and particles emitted from thermoplastic filaments during 3D printing
PublicationThe proliferation of consumer-grade three-dimensional (3D) printers using fused deposition, also known as fused filament fabrication, has given rise to concerns over the exposure of users to potentially harmful substances. Thermoplastic filaments made of different polymers are extruded through a heated printer nozzle and deposited layer by layer on a build platform to form the printed object. This process leads to the emission...
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Bee Pollen and Bee Bread as a Source of Bacteria Producing Antimicrobials
PublicationThe principal objective of the study was the isolation and identification of bacteria that are present in mature bee bread (BB) and dried (ready for selling and consumption) bee pollen (BP). Obtained isolates were screened for their potential to inhibit select human pathogenic bacteria and their ability to produce enzymes of particular industrial importance. Four and five samples of BP and BB, respectively, were used for the study....
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How can the work environment be redesigned to enhance the well-being of individuals with autism?
PublicationPurpose – This article examines the opportunities to create optimal conditions for individuals with autism, to work successfully within the contemporary workplace and improve their well-being. These opportunities arise from digital technology (DT) development, enabling the work environment to be remodeled by providing new possibilities and ways of working. The author discusses both technology-based as well as non-technological accommodations...
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A Study on Emission of Airborne Wear Particles from Car Brake Friction Pairs
PublicationThe emission of airborne wear particles from friction material / cast iron pairs used in car brakes was investigated, paying special attention to the influence of temperature. Five low-metallic materials and one non-asbestos organic material were tested using a pin-on-disc machine. The machine was placed in a sealed chamber to allow airborne particle collection. The concentration and size distribution of 0.0056 to 10 μm particles...
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Investigation of sour substances by five-channel potentiometric taste sensor containing all-solid-state-electrodes ( ASSEs)
PublicationAn elaboration of taste sensor for discrimination of different food products is of great importance for food industry. Potentiometric taste sensor containing ion selective electrodes with lipid/polymer membranes has already been applied commercially in food industry. However, time-consuming and demanding preconditioning method of ions selective electrodes as well as maintenance of electrodes’ bodies are disadvantages of this taste...
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INVESTIGATION OF SOUR SUBSTANCES BY FIVE-CHANNEL POTENTIOMETRIC TASTE SENSOR CONTAINING ALL-SOLID-STATE- ELECTRODES (ASSEs)
PublicationAn elaboration of taste sensor for discrimination of different food products is of great importance for food industry. Potentiometric taste sensor containing ion selective electrodes with lipid/polymer membranes has already been applied commercially in food industry. However, time-consuming and demanding preconditioning method of ions selective electrodes as well as maintenance of electrodes’ bodies are disadvantages of this taste...
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Persulfates to degrade a mixture of dyes (rhodamine B, methylene blue) in the presence of glucose and visible light
PublicationA treatment process utilizing visible-light-activated (Vis) persulfates (PS) in the presence of an organic promoter (glucose) was developed for the simultaneous decolorization of a rhodamine B (RhB) and methylene blue (MB) mixture. Various doses of glucose, PS concentrations, pH values, initial dye concentrations and process time were tested to find out the most appropriate parameters for degrading the RhB/MB mixture in the...
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Całkowite przekroje czynne na rozpraszanie elektronów na drobinach wieloatomowych
PublicationGłównym celem rozprawy doktorskiej było zmierzenie absolutnych całkowitych przekrojów czynnych (TCS) na rozpraszanie elektronów w szerokim zakresie energii (~1-400 eV) dla wybranych drobin: BCl3, B(CD3)3, NF3, N(CH3)3, P(CH3), SO2Cl2, SO2ClF, SF4, c-C2H4O oraz c-C3H6O (dla ośmiu drobin otrzymano całkowite przekroje czynne po raz pierwszy, natomiast dla dwóch pozostałych został znacznie rozszerzony zakres energii dostępnych danych)....
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Zastosowanie techniki NIR w analizie jakościowej surowców kosmetycznych i farmaceutycznych
PublicationW ramach współpracy pomiedzy Katedrą Technologii Leków i Biochemii Wydziału Chemicznego PG, a zakładem produkcji kosmetyków i farmaceutyków Ziaja Ltd. podjęto prace badawcze nad opracowaniem nowych metod analitycznych stosując spektroskopię w bliskiej podczerwieni (NIR). Metoda ta wykorzystuje absorpcję promieniowania elektromagnetycznego w zakresie 12 000 - 4 000 cm-1 (780-2500 nm). Absorpcja w zakresie NIR pochodzi głównie nod...
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Microporous Polyurethane Thin Layer as a Promising Scaffold for Tissue Engineering
PublicationThe literature describes that the most efficient cell penetration takes place at 200–500 µm depth of the scaffold. Many different scaffold fabrication techniques were described to reach these guidelines. One such technique is solvent casting particulate leaching (SC/PL). The main advantage of this technique is its simplicity and cost efficiency, while its main disadvantage is the scaffold thickness, which is usually not less than...
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Design Methodology for Small Passenger Ships On the Example of the Ferryboat Motława 2 Driven by Hybrid Propulsion System
PublicationDynamic development in practically all elds of science and engineering has not passed over shipbuilding . In last years , engineers got to their use computer soware which makes it possible to perform strength and hydrodynamic calculations as well as to visualize design projects in 3 D space [1-4]. At their disposal they have full spectrum of modern solutions associated with the use of advanced materials and technologies [5-7]....
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Wykonanie ekspertyzy technicznej Stadionu Miejskiego w Białymstoku. Część II. Analiza konstrukcji żelbetowej płyty jezdnej estakady na poziomie „+1”
PublicationPrzedmiotem opracowania jest konstrukcja żelbetowej płyty jezdnej estakady przyległej do krótszego boku korpusu Stadionu Piłkarskiego w Białymstoku, wykonanego w ramach inwestycji realizowanej przez OHL: ,,Budowa Stadionu Piłkarskiego w regionie północno – wschodniej Polski wraz z zapleczem treningowym”. Celem opracowania jest analiza przyczyn występowania wad i uszkodzeń estakady, w szczególności spękania masy wypełniającej szczeliny...
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Podstawy metodyki zarządzania projektami w ujęciu klasycznym
PublicationZagadnienia prezentowane w niniejszym podręczniku mają na celu przybliżenie Czytelnikom wiedzy i doświadczeń związanych z realizacją projektów, głównie na podstawie amerykańskiego standardu zarządzania projektami Project Management Body of Knowledge Guide, Edition Fourth (PMBOK). Standard ten jest źródłem wiedzy oraz powszechnie uznawanych tzw. dobrych praktyk, z powodzeniem stosowanych do skutecznego zarządzania projektami przez...
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Imigranci z Kazachstanu w Polsce w warunkach członkostwa w UE
PublicationImigranci z byłych krajów ZSRR rozpoczęli przybywać do Polski od 1992 r. Zjawisko to wiązało się z otwarciem polskich granic i ze zmianą sytuacji politycznej. Przyjazdy obywateli Kazachstanu były możliwe dzięki podpisaniu przez Polskę stosownych umów międzynarodowych, porozumień ramowych z Wspólnotami Europejskimi oraz umów bilateralnych podpisanych przez rząd Polski z rządem Kazachstanu. Choć nawiązanie stosunków dyplomatycznych...
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Microwave radiation in the synthesis of urethane prepolymers
PublicationThis paper describes the use of microwave radiation in the synthesis of urethane prepolymers in bulk (without solvent). The prepolymers were synthesized using 1,6-hexamethylene diisocyanate (HDI) and poly (ε-caprolactone) diol (PCL) at a molar ratio of 4:1. The reaction was carried out without a catalyst in the reactor with a conventional heating system (oil bath) or in the microwave reactor (MW Reactor NOVA 09) at temperatures...
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Opinia dotycząca zagadnień technologicznych w prowadzonej sprawie sądowej: sygn. akt XI GC 887/15 w zakresie postanowienia Sądu Rejonowego Szczecin-Centrum, Wydział XI Gospodarczy, z dnia 9 stycznia 2017 r.
PublicationCelem opinii, zgodnie z postanowieniem Sądu Rejonowego Szczecin – Centrum w Szczecinie z dnia 9 stycznia 2017 r., pod przewodnictwem Sędziego Sądu Rejonowego Andrzeja Muzyka, jest ustalenie: 1. Czy skrapiarka EKS 2000 jest przeznaczona do transportu lepiszczy bitumicznych oraz skropienia nimi nawierzchni przy budowie i naprawie dróg? 2. Czy składnikiem takich lepiszczy jest cement? 3. Czy prawidłowym jest dodawanie...
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Solid state versus fiber picosecond infrared lasers applied to two-photon vision tests
PublicationDevelopment of new microperimetric tools dedicated for imaging of early functional changes in the retina may help in the monitoring of various ocular diseases progression e.g. Age-Related Macular Degeneration. Recently described two-photon vision may be applied to microperimetric devices. Many subjects with well-known disease history could be investigated with newly developed instrumentation that tests ability of human eye to perceive...
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Level of public finances decentralization in European Union countries
PublicationResearch background: Despite of the universality of the implementation in democratic countries the principle of decentralization resulting from the belief that it is an instrument to improve the efficiency of public funds management, both the scope of public services and the level of decentralization in individual countries are not identical. Purpose of the article: Comparison the scope of fiscal decentralization...
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A Low-Profile Metal-backed Dipole Loaded with Closely Coupled Arc-shaped Open Stubs for On-metal Tag Design with Wide Frequency Tuning Capability
PublicationThis research has presented a single-layer metal-backed dipole antenna, which consists of a feedline loaded with two pairs of closely-coupled arc-shaped open stubs, for designing a metal-mountable tag that features tuning capability over a wide range of frequency. Here, the stubs can generate sufficient inductive reactance for bringing down the tag resonant frequency tunable in both the regulated UHF RFID passbands (North American...
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Topological behavior mimicking ethylene–hexene copolymers using branched lactones and macrolactones
PublicationPolyolefins are of paramount importance in the world of polymers due to their technological and economic potential.1 However, their nonpolar character significantly restricts the compatibility and adhesion properties, which consequently limits their versatility. Moreover, an intensified demand for materials from renewable resources can also become a problematic venture for the current polyolefin industry.2 Although Braskem and...
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A new open-source software developed for numerical simulations usingdiscrete modeling methods
PublicationThe purpose of this work is to present the development of an open-source software based on a discrete description of matter applied to study the behavior of geomaterials. This software uses Object Oriented Programming techniques, and its methodology design uses three different methods, which are the Discrete Element Method (DEM) [F. Donzé, S.A. Magnier, Formulation of a three-dimensional numerical model of brittle behavior, Geophys....
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UZUPEŁNIENIE TEKSTU ZALECEŃ DLA OPRACOWANIA: Ekspertyza techniczna dotycząca przestrojenia konstrukcji stadionu żużlowego w Zielonej Górze z analizą numeryczną w formalizmie metody elementów skończonych
PublicationPrzedmiotem orzeczenia jest wskazanie metody (lub metod) przestrojenia konstrukcji stadionu żużlowego w celu poprawy jego dynamiki przy obciążeniu synchronicznym skokiem grupy ludzi. Zakres prac badawczych obejmował:określenie częstości i postaci drgań stadionu ze wzmocnieniem słupkami (stan aktualny stadionu żużlowego) oraz wykonanie symulacji obciążenia synchronicznym skokiem grupy ludzi (wzmocnienie nr 1); określenie częstości...
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Ekspertyza techniczna dotycząca przestrojenia konstrukcji stadionu żużlowego w Zielonej Górze z analizą numeryczną w formalizmie metody elementów skończonych
PublicationPrzedmiotem orzeczenia jest wskazanie metody (lub metod) przestrojenia konstrukcji stadionu żużlowego w celu poprawy jego dynamiki przy obciążeniu synchronicznym skokiem grupy ludzi. Zakres prac badawczych obejmował: określenie częstości i postaci drgań stadionu ze wzmocnieniem słupkami (stan aktualny stadionu żużlowego) oraz wykonanie symulacji obciążenia synchronicznym skokiem grupy ludzi (wzmocnienie nr 1); określenie częstości...
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Zrównoważony rozwój lokalny. Podstawy teoretyczne i działania praktyczne
PublicationRozwój zrównoważony to jedna z koncepcji rozwoju lokalnego. Celem monografii jest prezentacja podstaw tego rozwoju na poziomie lokalnym oraz ukazanie jego przejawów i działań praktycznych w sferach gospodarczej, społecznej i ekologicznej, ze szczególnym uwzględnieniem dwóch wewnętrznych czynników rozwojowych – turystyki i oświaty. W pierwszym rozdziale przedstawiono teoretyczne podstawy rozwoju lokalnego. Omówiono najpowszechniej...
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Deep learning for ultra-fast and high precision screening of energy materials
PublicationSemiconductor materials for energy storage are the core and foundation of modern information society and play important roles in photovoltaic system, integrated circuit, spacecraft technology, lighting applications, and other fields. Unfortunately, due to the long experiment period and high calculation cost, the high-precision band gap (the basic characteristic parameter) of semiconductor is difficult to obtain, which hinders the...
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Long-Term Stability of Benzodiazepines and Z-Hypnotic Drugs in Blood Samples Stored at Varying Temperatures
PublicationBenzodiazepines (BZDs) and Z-drugs are among the most commonly prescribed pharmaceuticals in the world and are considered standard care for various mental illnesses and for treatment of sleeping and anxiety disorders, alcohol withdrawal, muscle spasms and epilepsy. Some BZDs are not allowed as pharmaceuticals in many countries, and they are used as "designer benzodiazepines" (DBZDs). All these compounds are typically screened in...
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Możliwości energetycznego wykorzystania osadów ściekowych jako paliwa
PublicationObecnie szeroko dyskutowana jest efektywność energetyczna oczyszczalni, stąd istotnym zagadnieniem staje się prawidłowe wykorzystanie potencjału energetycznego osadów ściekowych (CHP i ITPO). Realizacja termicznej przeróbki osadów ściekowych wymaga znajomości właściwości energetycznych (ciepło spalania, wartość opałowa, zawartość wody) oraz składu pierwiastkowego, wskazującego na zawartość substancji lotnych i mineralnych osadów...
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Human UDP-Glucuronosyltransferases: Effects of altered expression in breast and pancreatic cancer cell lines.
PublicationIncreased aerobic glycolysis and de novo lipid biosynthesis are common characteristics of invasive cancers. UDP-glucuronosyltransferases (UGTs) are phase II drug metabolizing enzymes that in normal cells possess the ability to glucuronidate these lipids and speed their excretion; however, de-regulation of these enzymes in cancer cells can lead to an accumulation of bioactive lipids, which further fuels cancer progression. We hypothesize...
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Fotometryczny czujnik glukozy oparty na enzymatycznych paskach testowych
PublicationCukrzyca jest chorobą dotykającą co roku na całym świecie około 3 mln ludzi [1]. Brak możliwości wyleczenia choroby generuje koszty związane z jej monitorowaniem. W USA corocznie wydaje się na ten cel 174 mld dolarów [2]. Stężenie glukozy we krwi zdrowego człowieka na czczo waha się od 80 mg/dl do 110 mg/dl [3]. Stan organizmu z niedoborem glukozy nazywany jest hipoglikemią, a stan podwyższonej zawartości cukru – hiperglikemią...
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Electrochemical detection of bacterial endotoxin lipopolysaccharide (LPS) on gold electrode modified with DAL-PEG-DK5-PEG-OH - Antimicrobial peptide conjugate
PublicationThis work describes fabrication of gold electrodes modified with peptide conjugate DAL-PEG-DK5-PEG-OH that enables ultra-sensitive detection of lipopolysaccharide (LPS) isolated from the reference strain of Escherichia coli O26:B6. The initial step of the established procedure implies immobilization of the fully protected DAL-PEG-DK5-PEG-OH peptide on the surface of the gold electrode previously modified by cysteamine. Then side...
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Improved degradation of etodolac in the presence of core-shell ZnFe2O4/SiO2/TiO2 magnetic photocatalyst
PublicationIn the present study, susceptibility to photocatalytic degradation of etodolac, 1,8-diethyl-1,3,4,9 – tetrahydro pyran - [3,4-b] indole-1-acetic acid, which is a non-steroidal anti-inflammatory drug frequently detected in an aqueous environment, was for the first time investigated. The obtained p-type TiO2-based photocatalyst coupled with zinc ferrite nanoparticles in a core-shell structure improves the separation and recovery...
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Wykorzystanie bezrozpuszczalnikowych technik przygotowania próbek w procedurach oznaczania lotnych związków chlorowcoorganicznych w próbkach płynów biologicznych
PublicationDążność do oznaczania możliwie szerokiego spektrum analitów w próbkach charakteryzujących się złożonym, a często i zmiennym składem matrycy, stanowi siłę napędową do działań analityków w zakresie poszukiwania zarówno nowych rozwiązań metodycznych jak i aparaturowych. Szczególnie w przypadku ciekłych próbek środowiskowych i biologicznych konieczne są specjalne operacje i czynności (na etapie ich przygotowania) przed etapem oznaczeń...
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The productive function of the will in the pfilosophical thought of William James
PublicationW artykule przedstawiłem W. Jamesa koncepcję wolnej woli w jej wytwórczej funkcji. Pokazałem, że zrównuje ona ludzkie poznanie i ludzką aktywność. Następnie podkreśliłem, że wola ma wieloaspektowy charakter w formowaniu nowego "wewnętrznego człowieka". W związku z tym, zanalizowałem tzw. empiryczne 'ja' jako "niższe" i "wyższe" 'ja'. Z kolei podkreśliłem walor konsekwencji teleologicznej cechy ludzkiej...
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Influence of laser melting on surface layer properties of titanium alloy Ti6Al4V
PublicationIn time of rapid technology and medicine progress, implants are becoming more widely used in the human body, ranging from dental implants, stabilizing plates, screws, orthopaedic prostheses. For example, there are many types of hip prostheses used for hip replacement as well as various types of materials used for these orthopaedic prostheses. Properties of titanium alloys used in hip prostheses combined with good strength properties,...
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Assessment of the Relationship between the Shape of the Lateral Meniscus and the Risk of Extrusion Based on MRI Examination of the Knee Joint
PublicationBackground Meniscus extrusion is a serious and relatively frequent clinical problem. For this reason the role of different risk factors for this pathology is still the subject of debate. The goal of this study was to verify the results of previous theoretical work, based on the mathematical models, regarding a relationship between the cross-section shape of the meniscus and the risk of its extrusion. Materials and Methods Knee...
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High prevalence of Escherichia coli belonging to the B2+D phylogenetic group in inflammatory bowel disease
PublicationBACKGROUND: It is not clear which species of bacteria may be involved in inflammatory bowel disease (IBD). One way of determining which bacteria might be likely candidates is to use culture-independent methods to identify microorganisms that are present in diseased tissues but not in controls. AIMS: (1) To assess the diversity of microbial communities of biopsy tissue using culture-independent methods; (2) to culture the bacteria...
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Drug-drug interaction potential of antitumor acridine agent C-1748: The substrate of UDP-glucuronosyltransferases 2B7, 2B17 and the inhibitor of 1A9 and 2B7
PublicationBackground The compound 9-(2′-hydroxyethylamino)-4-methyl-1-nitroacridine (C-1748), the promising antitumor agent developed in our laboratory was determined to undergo phase I metabolic pathways. The present studies aimed to know its biotransformation with phase II enzymes – UDP-glucuronosyltransferases (UGTs) and its potential to be engaged in drug-drug interactions arising from the modulation of UGT activity. Methods UGT-mediated...
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Investigation of sweet substances of different molecular structure by potentiometric taste sensor with all solid state electrodes
PublicationA five channel potentiometric taste sensor consisting of an array of All Solid State Electrodes (ASSESs) with different lipid-polymer membranes has been developed. The electrodes are constructed of glassy carbon discs with electrochemically deposited poly(3,4-ethylenedioxythiophene) (PEDOT) acting as ion to electron transducer. The outer layer of the electrode is lipid-polymer membrane. Lipid substances immobilized in PVC membranes...