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Prenatal exposure to substance of abuse: A worldwide problem
PublicationSubstance abuse during pregnancy is an important public health issue affecting the mother and the growing infant. Preterm labor, miscarriage, abruption and postpartum hemorrhage are obstetric complications which have been associated with women who are dependent on abused substances. Moreover, women are also at an increased risk of medical problems such as poor nutrition, anemia, urinary tract infections as well as sexually transmitted...
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The influence of food phytochemicals on cyclic phosphodiesterase 4 (PDE4) activity
PublicationCyclic phosphodiesterase 4 (PDE4) belongs to family of cyclic phosphodiesterases, which are expressed predominantly in inflammatory cells, airway smooth muscles, cardiovascular tissues and brain. Inhibitors of this family of enzymes found medicinal applications as antidepressants, antiinflamatory drugs (mainly in airway diseases) or antiasthmatics (Ibudilast). PDE4 inhibitors are also being tested for preventing the development...
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Indole-Acrylonitrile Derivatives as Potential Antitumor and Antimicrobial Agents—Synthesis, In Vitro and In Silico Studies
PublicationA series of 2-(1H-indol-2-yl)-3-acrylonitrile derivatives, 2a–x, 3, 4a–b, 5a–d, 6a–b, and 7, were synthesized as potential antitumor and antimicrobial agents. The structures of the prepared compounds were evaluated based on elemental analysis, IR, 1H- and 13NMR, as well as MS spectra. X-ray crystal analysis of the representative 2-(1H-indol-2-yl)-3-acrylonitrile 2l showed that the acrylonitrile double bond was Z-configured. All...
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Electrophoretic Deposition of Chitosan/Eudragit E 100/AgNPs Coatings for Controlled Release of Antibacterial Substance
PublicationThe development of bacterial infection of the tissues surrounding an implant is one of the leading causes of implant surgery failure. In order to prevent the deposition of bacteria on the implant surface and the formation of biofilm, coatings that exhibit antibacterial properties are manufactured. However, the problem is the controlled release of the therapeutic substance from the coating over the extended life of the implant [1],...
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Validation and modification of HPLC method for monitoring acetaminophen plasma concentrations in patients with chronic pancreatitis
PublicationBackground. Pancreatitis is the inflammation of the pancreas. The infl ammation may occur suddenly and resolve in a few days with the treatment in case of acute pancreatitis (AP). Chronic pancreatitis (CP) is a persistent inflammation of the pancreas that results in irreversible morphological changes and impairment of both exocrine and endocrine functions. Abdominal...
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Novel Resveratrol-Based Substrates for Human Hepatic, Renal, and Intestinal UDP-Glucuronosyltransferases
PublicationTrans-Resveratrol (tRes) has been shown to have powerful antioxidant, anti-inflammatory, anti-carcinogenic, and anti-aging properties; however, its use as a therapeutic agent is limited by its rapid metabolism into its conjugated forms by UDP-Glucuronosyltransferases (UGTs). The aim of the current study was to test the hypothesis that the limited bioavailability of tRes can be improved by modifying its structure to create analogs...
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The antitumor compound triazoloacridinone C-1305 inhibits FLT3 kinase activity and potentiates apoptosis in mutant FLT3-ITD leukemia cells.
PublicationAim: FMS-like receptor tyrosine kinase (FLT3) is expressed in some normal hematopoietic cell types and plays an important role in the pathogenesis of acute myeloid leukemia (AML). In this study, we examined the effects of triazoloacridinone C-1305, an antitumor compound, on AML cells with different FLT3 status in vitro. Methods: A panel of human leukemic cell lines with different FLT3 status was used, including FLT3 internal tandem...
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Rapid and simple multi-analyte LC–MS/MS method for the determination of benzodiazepines and Z-hypnotic drugs in blood samples: Development, validation and application based on three years of toxicological analyses
PublicationBenzodiazepines (BZDs) and Z-drugs have been particularly important treatments for sleeping and anxiety disorders for many years. However, recently, a number of new benzodiazepines (named designer benzodiazepines, DBZDs) were synthesised, but some of them have never been used in the clinic; they reached the black drug market as new psychoactive substances and are used for recreational purposes. The abuse of these substances has...
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Uwarunkowania obsługi transportowej miast elektrobusami na przykładzie Sopotu
PublicationPojazdy o napędzie elektrycznym stanowią jeden z filarów realizacji polityki zrównowa-żonej mobilności w miastach i aglomeracjach. Ponad stuletnie doświadczenia w eksploatacji tramwajów, trolejbusów i miejskich kolei elektrycznych zdeterminowały kierunki rozwoju technologicznego tych środków transportu oraz zakres ich wykorzystania w realizacji potrzeb przewozowych mieszkańców obszarów zurbanizowanych. Rozwój nowoczesnych technologii...
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Project management for the construction sector in the field of foundation of buildings in complex conditions of the subsoil
PublicationAutorzy: Gwóźdź-Lasoń Monika, Kohutek...
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Chicken feather keratin as a source of bioactive peptides useful in prevention of metabolic disorders – in silico and in vitro hydrolysis
PublicationProtein derived bioactive peptides not only serve as nutrients but can also exert drug-like activity, e.g. antidiabetic, antihypertensive, or antimicrobial, to name a few. Most biopeptides have beneficial effects on health that make them attractive for nutraceutical applications. The majority of bioactive peptides have been obtained from food proteins, but protein-rich by-products generated by agriculture...
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A method for the production of D-tagatose using a recombinant Pichia pastoris strain secreting beta-D-galactosidase from Arthrobacter chlorophenolicus and a recombinant L-arabinose isomerase from Arthrobacter sp. 22c
PublicationD-Tagatose is a natural monosaccharide which can be used as a low-calorie sugar substitute in food, beverages and pharmaceutical products. It is also currently being tested as an anti-diabetic and obesity control drug. D-Tagatose is a rare sugar, but it can be manufactured by the chemical or enzymatic isomerization of D-galactose obtained by a beta-D-galactosidase-catalyzed hydrolysis of milk sugar lactose and the separation of...
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Caffeine Inhibits Differentiation Of Lung Cancer Stem Cells By Modulating Their Respiratory Metabolism
PublicationIt is ell established that many tumor types contain a fraction of cells, with stem cell-like properties, called cancer stem cells (CSCs), that are resistant to apoptosis induced by therapeutic agents. The presence of CSCs may explain why a standard anticancer treatment, that eliminates only differentiated cancer cells, does not lead to cancer cure.We previously showed the existence of caffeine-sensitive mechanism that controls...
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Project management for the construction sector in the field of foundation of designed residential building located in this area with the expected impact of mining operation
PublicationAutorzy: Gwóźdź-Lasoń Monika, Berski Łukasz.
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Analysis of investment stages along with a construction project management project for an investment task regarding the reconstruction and expansion of the locomotor system rehabilitation center Krzeszowice SPZOZ in Poland
PublicationAutorzy: Gwóźdź-Lasoń Monika, Tkocz Sebastian.
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Ogród muz I
PublicationNiniejsza książka składa się z dwóch części. W pierwszej znajdują się eseje wprowadzające Czytelnika w tematykę obecności tradycji antycznej w Gdańsku wczesnonowożytnym. Ich autorami są młodzi badacze z różnych ośrodków akademickich. Część druga to katalog wystawy, która miała miejsce w siedzibie Polskiej Akademii Nauk Biblioteki Gdańskiej (19 czerwca do 31 lipca 2015 roku). Na ekspozycji zaprezentowano stare druki i rękopisy...
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W gdańskim ogrodzie muz. Gimnazjum Akademickie w Gdańsku wobec kultury starożytnych Greków i Rzymian: idee, teksty, artefakty.
PublicationNiniejsza książka składa się z dwóch części. W pierwszej znajdują się eseje wprowadzające Czytelnika w tematykę obecności tradycji antycznej w Gdańsku wczesnonowożytnym. Ich autorami są młodzi badacze z różnych ośrodków akademickich. Część druga to katalog wystawy, która miała miejsce w siedzibie Polskiej Akademii Nauk Biblioteki Gdańskiej (19 czerwca do 31 lipca 2015 roku). Na ekspozycji zaprezentowano stare druki i rękopisy...
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Development of Biocompatible Fe3O4@SiO2 Nanoparticles as Subcellular Delivery Platform for Glucosamine-6-phosphate Synthase Inhibitors
PublicationNumerous inhibitors of glucoseamine-6-phophate synthase (GlcN-6-P), the enzyme responsible from catalysis of the first step of metabolic pathway leading to metabolism 5’-diphospho-N-acetyl-D- glucosamine, were reported as effective agents for inhibiting the growth of various fungal pathogens. Among the reported inhibitors,...
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Intermolecular Interactions of Edaravone in Aqueous Solutions of Ethaline and Glyceline Inferred from Experiments and Quantum Chemistry Computations
PublicationEdaravone, acting as a cerebral protective agent, is administered to treat acute brain infarction. Its poor solubility is addressed here by means of optimizing the composition of the aqueous choline chloride (ChCl)-based eutectic solvents prepared with ethylene glycol (EG) or glycerol (GL) in the three different designed solvents compositions. The slurry method was used for spectroscopic solubility determination in temperatures...
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A European Multi Lake Survey dataset of environmental variables, phytoplankton pigments and cyanotoxins
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The CMS experiment at the CERN LHC
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