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Search results for: DRUG SCREENING PLATFORM
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Bovine Serum Albumin – Hydroxyapatite Nanoflowers as Potential Local Drug Delivery System of Ciprofloxacin
PublicationIntroduction: Hybrid nanoflowers are structures consisting of organic (enzymes, proteins, nucleic acids) and inorganic components (mostly metal phosphates) with a flower-like hierarchical structure. Novel hybrid nanoflowers based on bovine serum albumin (BSA) and hydroxyapatite (HA) were obtained and characterized. Study on BSA-HA nanoflowers as potential drug delivery system is reported for the first time. Methods: Embedding ciprofloxacin...
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Exposure to non-opioid analgesics during pregnancy and the risk of adverse drug reactions
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Installation of GNSS receivers on a mobile railway platform – methodology and measurement aspects
PublicationDetermining the course of a railway track axis using satellite methods relies on ensuring the precise assembly of GNSS receivers in dedicated measuring devices. Depending on the number of receivers, solutions that are based on placing the apparatus directly above the railway track axis (as well as in eccentric positions) are used to indirectly obtain data to form the basis of the desired results. This publication describes the...
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Wykorzystanie technologii Java 2 Platform,Enterprise Edition do wytwarzania usług internetowych
PublicationPlatforma J2EE jest jedną z najpopularniejszych platform wytwarzania systemów, aplikacji i usług internetowych. Jest ona oparta na tech-nologii Java i udostępnia wiele komponentów ułatwiających tworzenie usług internetowych. W niniejszym artykule przedstawiono dostępne komponenty i usługi jakie ta platforma dostarcza wraz z wybranymi przykładami tworzenia i użycia niektórych z nich. Dodatkowo przedstawione są kierunki rozwoju tej...
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Badanie wytrzymałości zaczynu cementowego na ściskanie przeznaczonego do wypełnienia elementów konstrukcyjnych platform wiertniczych.
PublicationPrzedmiotem opracowania było badanie wytrzymałości zaczynu cementowego na ściskanie o wytrzymałości 70-80 MPa przeznaczonego do wypełnienia elementów konstrukcji platform wiertniczych pod wodą.
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Low-Barrier Hydrogen Bond Determines Target-Binding Affinity and Specificity of the Antitubercular Drug Bedaquiline
PublicationThe role of short strong hydrogen bonds (SSHB) in ligand-target binding remains largely unexplored, thereby hin- dering a potentially important avenue in the rational drug de- sign. Here, we investigate the interaction between bedaquiline (Bq), a potent anti-tuberculosis drug, and the mycobacterial ATP synthase, to unravel the role of a specific hydrogen bond to a conserved acidic residue in the target affinity and specificity....
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Elastic-contractile model proteins: Physical chemistry, protein function and drug design and delivery
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Adaptation of Architectural Heritage in the Era of Climate Change. Torpedo Platform in Babie Doły
PublicationThe paper provides original insight into the problem of adap¬tation of historical objects in the era of climate change. It conveys a message that in times of climate crisis, there is a need to go beyond an anthropocentric perspective, specifically, that architec¬ture should not only be designed for people, but should also provide a framework for nature. As well as shaping spaces for human beings, the architect is also responsible...
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Video Classification Technology in a Knowledge-Vision-Integration Platform for Personal Protective Equipment Detection: An Evaluation
PublicationThis work is part of an effort for the development of a Knowledge-Vision Integration Platform for Hazard Control (KVIP-HC) in industrial workplaces, adaptable to a wide range of industrial environments. This paper focuses on hazards resulted from the non-use of personal protective equipment (PPE), and examines a few supervised learning techniques to compose the proposed system for the purpose of recognition of three protective...
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APPLICATION OF VIBRATION SIGNALS IN RAILWAY TRACK DIAGNOSTICS USING A MOBILE RAILWAY PLATFORM
PublicationThe article presents a comprehensive method for using vibration signals to diagnose railway tracks. The primary objective is to gather detailed information on track conditions through a passive experiment. This involves using mobile diagnostic tools and techniques to assess railway infrastructure. The article elaborates on the range of diagnostic activities conducted in accordance with detailed railway regulations and highlights...
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Wzmocnienie podstaw nasypów i wykonanie platform roboczych na słabym podłożu
PublicationGeoruszty w budownictwie infrastrukturalnym, a zwłaszcza komunikacyjnym i w geotechnice, są stosowane od dziesięcioleci. Pomimo tego wciąż stosunkowo słabo rozpowszechnione są metody projektowania rozwiązań z wykorzystaniem tych materiałów. O ile zastosowania georusztów (czy też szerzej: geosyntetyków) w konstrukcjach z gruntu zbrojonego (ściany oporowe, strome skarpy) i związane z tym metody projektowe są dobrze opisane w literaturze...
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Dynamically configurable platform for service integration
PublicationW artykule opisano architekturę konfigurowalnego dynamicznie środowiska dla aplikacji zorientowanych na usługi, w szczególnosci na usługi webowe. Środowisko szkieletowe bazujace na specyfikacji OSGi dostarcza interfejsu, dzięki któremu zarzadzanie logika aplikacji nie wymaga jej ponownego uruchomienia. Opisano kluczowe problemy, które muszą być rozwiązane podczas wytwarzania tego typu rozwiązań. zaprezentowano sposób współpracy...
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Smart Email - Almost an Agent Platform
PublicationNetwork organizations suffer today of information overload and strain that rise their operational costs. One of the reasons of that is the dominance of email messaging as the princi-pal means of document exchange between their workers. Proac-tive documents can rationalize these costs and augment email systems with a process view based on collaboration patterns.
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KASKADA - multimedia processing platform architecture
PublicationPrzedstawiono architekturę platformy KASKADA (skrót od: Kontekstowa Analiza Strumieni Danych z Kamer do Aplikacji Definiujących Alarmy), będącą częścią projektu MAYDAY EURO 2012. Opisano nowy wielowarstwowy model przetwarzania strumieni multimedialnych. Zaproponowano następujące warstwy: usług - prostych i złożonych, zadań obliczeniowych i procesów. Przedstawiono przykładowy scenariusz wraz ze szczegółami jego wykonania, jak również...
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The task graph assignment for KASKADA platform
PublicationArtykuł opisuje model obliczeniowy wykorzystany w platformie KASKADA. Opiera się on na dwóch podstawowych elementach: węzłach klastra obliczeniowego oraz grafie zadań. Przeanalizowane zostały algorytmy przydzielania węzłów obliczeniowych dla zadań w zależności od kryteriów: minimalizacja fragmentacji klastra i minimalizacja opóźnienia przetwarzania danych. Zostały przedstawione wyniki symulacji opisanych algorytmów oraz ich...
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Measurement platform for training of electronic nose
PublicationW pracy zaprezentowano platformę do badania elektronicznego nosa. Zaproponowane rozwiązanie umożliwia trening elektronicznego nosa oraz pomiar charakterystyk czujników gazów.
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Optical properties of the chemotherapy drugs used in the central nervous system lymphoma therapy: monitoring drug delivery
PublicationOur aim is to optically monitor the delivery of the chemotherapy drugs for brain tumours, particularly used in the central nervous system (CNS) lymphoma therapy. In vivo monitoring would help to optimize the treatment and avoiding unnecessary medications. Moreover, it would be beneficial to be able to measure which of the multi-regimen drugs actually do penetrate and how well into the brain tissue. There exist several potential...
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The use of HPLC-Q-TOF-MS for comprehensive screening of drugs and psychoactive substances in hair samples and several “legal highs” products
PublicationNon-targeted screening of drugs present in herbal products, known as “legal high” drugs and in hair as a biological matrix commonly used in toxicological investigations was accomplished with the use of high pressure liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (HPLC-Q-TOF-MS). In total, 25 and 14 therapeutical drugs and psychoactive substances/metabolites were detected in investigated hair samples...
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pH-Responsive Drug Delivery Nanoplatforms as Smart Carriers of Unsymmetrical Bisacridines for Targeted Cancer Therapy
PublicationSelective therapy and controlled drug release at an intracellular level remain key challenges for effective cancer treatment. Here, we employed folic acid (FA) as a self-navigating molecule in nanoconjugates containing quantum dots (QDs) and β-cyclodextrin (β-CD) for the delivery of antitumor unsymmetrical bisacridine compound (C-2028) to lung and prostate cancers as well as normal cells. The bisacridine derivative can form the...
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Drug-resistant and hospital-associated Enterococcus faecium from wastewater, riverine estuary and anthropogenically impacted marine catchment basin.
PublicationEnterococci, ubiquitous colonizers of humans and other animals, play an increasingly important role in health-care associated infections (HAIs). Acquisition of resistance determinants not only seriously limits available therapeutic options but also increases available gene pool for other species. It is believed that the recent evolution of two clinically relevant species, Enterococcus faecalis and Enterococcus faecium occurred...
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Drug-Eluting Biopsy Needle as a Novel Strategy for Antimicrobial Prophylaxis in Transrectal Prostate Biopsy
PublicationOBJECTIVES: To preclinically evaluate drug-eluting biopsy needles (patent pending WO2016118026) as a new potential way of antimicrobial prophylaxis for transrectal prostate biopsy. METHODS: Twenty steel biopsy needles have been coated with polyvinyl alcohol, ciprofloxacin, and amikacin. Modified biopsy needles have been randomly divided into 3 groups (1:2:1 ratio). Needles from group I were immersed for 30 minutes in dedicated...
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User -friendly E-learning Platform: a Case Study of a Design Thinking Approach Use
PublicationE-learning systems are very popular means to support the teaching process today. These systems are mainly used by universities as well as by commercial training centres. We analysed several popular e-learning platforms used in Polish universities and find them very unfriendly for the users. For this reason, the authors began the work on the creation of a new system that would be not only useful, but also usable for students, teachers...
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Double layer adhesive silicone dressing as a potential dermal drug delivery film in scar treatment
PublicationThe present studies focused on the evaluation of design of an adhesive silicone film intended for scar treatment. Developed silicone double layer film was examined in terms of its future relevance to therapy and applicability on the human skin considering properties which included in vitro permeability of water vapor and oxygen. In order to adapt the patches for medical use in the future there were tested such properties as...
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ENCAPSULATION OF ROXITHROMYCIN INTO GELLAN GUM MATRICES AND THE IMPACT OF OTHER NATURAL POLYMERS ON DRUG RELEASE
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A five-year retrospective study shows increasing rates of antimicrobial drug resistance in Cabo Verde for both Staphylococcus aureus and Escherichia coli
PublicationObjectives Data on baseline drug resistance is important in informing future antimicrobial stewardship programs. So far, no data on the antimicrobial drug resistance of clinical isolates was available for the African archipelago of Cabo Verde. Methods We have performed a retrospective analysis over five-years (2013-17) of the antimicrombial drug susceptibility profiles of clinical isolates in the two main hospitals of Cabo Verde....
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NLITED - New Level of Integrated Techniques for Daylighting Education: Preliminary Data on the Use of an E-learning Platform
PublicationProject NLITED – New Level of Integrated Techniques for Daylighting Education - is an educational project for students and professionals. The project's objective is to create and develop an online eLearning platform with 32 eModules dedicated to daylight knowledge. The project also offers e-learners two summer school training where the theory is put into practice. The platform was launched on January 31, 2022. The paper...
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Journal of Inborn Errors of Metabolism and Screening
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Newborn screening and gene therapy in SMA: Challenges related to vaccinations
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Screening for Antagonistic Yeasts to Manage Alternaria spp. in Organic Farming
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Glutathione-mediated conjugation of anticancer drugs: an overview of reaction mechanisms and biological significance for drug detoxification and bioactivation.
PublicationThe effectiveness of many anticancer drugs depends on the creation of specific metabolites that may alter their therapeutic or toxic properties. One significant route of biotransformation is a conjugation of electrophilic compounds with reduced glutathione, which can be non-enzymatic and/or catalyzed by glutathione-dependent enzymes. Glutathione usually combines with anticancer drugs and/or their metabolites to form more polar...
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Kamila Kokot-Kanikuła mgr
PeopleKamila Kokot-Kanikuła is a digital media senior librarian at Gdańsk University of Technology (GUT) Library. She works in Digital Archive and Multimedia Creation Department and her main areas of interests include early printed books, digital libraries, Open Access and Open Science. In the Pomeranian Digital Library (PDL) Project she is responsible for creating annual digital plans, transferring files on digital platform, and promoting...
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A miniaturized solid-contact potentiometric multisensor platform for determination of ionic profiles in human saliva
PublicationThis paper describes a miniaturized multisensor platform (MP-ISES) consisting of electrodes: a reference one (RE) and ion-selective electrodes (ISEs) for monitoring Na+, K+, Ca2+, Mg2+, Cl−, and SCN− ions and pH in human saliva. Gold electrode surface was modified by deposition of two layers: electrosynthesized PEDOT:PSS forming an intermediate layer, and ion-selective membrane. The developed ISEs were characterized by a wide linear...
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On extending open source IMS platform for integrated IPTV and VoIP services over IPv6
PublicationEven when IMS is the most popular platform for multimedia services, the open versions of IMS ecosystem are lacking in specified functionalities for IPTVv6 and VoIPv6 services. In this paper, we extend current client and server open source software in order to provide reliability and security to these multimedia services. As a part of our work the IMS architecture for conferencing system with proposed mechanisms to improve system...
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HILS for the Design of Three-Wheeled Mobile Platform Motion Surveillance System with a Use of Energy Performance Index
PublicationCurrent tendency in mechatronic design requires the use of comprehensive development of an environment, which gives the possibility to prototype, design, simulate and integrate with dedicated hardware. The paper discusses the Hardware-In-the-Loop Simulations (HILS) mechatronic technique, used during the design of the surveillance system based on energy performance index. The presented test configuration (physical controller – emulated...
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Drug Research
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DRUG DELIVERY
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DRUG SAFETY
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Drug Topics
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AUTONOMOUS PLATFORM TO PROTECT MARITIME INFRASTRUCTURE FACILITIES
PublicationProblems regarding the security of maritime infrastructure, especially harbours and offshore infrastructure, are currently a very hot topic. Due to these problems, there are some research projects in which the main goal is to decrease the gap and improve the methods of observation in the chosen area, for both in-air and underwater areas. The main goal of the paper is to show a new complex system for improving the security of the...
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Ice Load Characteristics on Floating Photovoltaic Platform
PublicationNowadays, based upon human needs and preferring perpetual types of energy, photovoltaic system (PV) is a suitable alternative and more frequently used in northern countries, which are recently more attracted by solar power. The new floating type of the structure is installed in the water bodies instead of land. One of the main elements in floating photovoltaic structures is the forces imposed on the panels. In the northern regions,...
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Realization, programming and controlling of the Stewart-Gough platform
PublicationThis paper presents realizaon, programming, and controlling of a low cost Stewart-Gough plaorm (SGP) with rotary actuators. The realized SGP is applied in a ball & plate control system. Developed dedicated software consists of embedded and applicaon soware for both the SGP posioning system and the ball & plate control. system. A ball posion is being obtained using computer vision. The paper contains tests results for both an SGP...
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Application of the GNU Radio platform in the multistatic radar
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Multimodal platform for continuous monitoring of elderly and disabled
PublicationArtykuł opisuje założenia do realizacji wielomodalnej platformy monitoringu osób starszych i chorych
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Multimodal Platform for Continuous Monitoring of the Elderly and Disabled
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The Bridge to Knowledge – Open Access to Scientific Research Results on Multidisciplinary Open System Transferring Knowledge Platform
PublicationThe European policy of Open Access to scientific research is now one of the key issues discussed in public debates on the future development of scientific communication. The implementation of Open Access tools has significant impact on scientific and economic growth. On the one hand, Open Access accelerates disseminating new research findings and facilitates recognition of authors on a more global scale. On the other hand, Open...
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Thin layer chromatography in drug discovery process
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Antifungal activity of propolis extracts, screening and kinetic data
Open Research DataThis folder contains results of our studies aiming in determination of antifungal potential of ethanolic extracts of propolis and components of this product. In details, MIC, MFC values were determined and kill time assays were performed.
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The Interaction of Heptakis (2,6-di-O-Methyl)-β-Cyclodextrin with Mianserin Hydrochloride and Its Influence on the Drug Toxicity
PublicationOne tetracyclic antidepressant, mianserin hydrochloride (MIA), has quite significant side effects on a patients’ health. Cyclodextrins, which are most commonly used to reduce the undesirable features of contained drugs within their hydrophobic interior, also have the potential to alter the toxic behavior of the drug. The present paper contains investigations and the characteristics of interaction mechanisms for MIA and the heptakis...
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Screening evaluation of the quality of commercially available cigars, cigarillos, and bidis based on emission levels of selected terpenes and terpenoids
PublicationThe aim of the research was to verify the use of the solvent-free, non-destructive and easy to operate analytical method to study and compare the emissions of 16 representatives of terpenes and terpenoids from commercially available cigars, cigarillos and bidis − a potential screening analysis for the quality of combustible tobacco products. To assess the amount of organic compounds emitted to the gaseous phase from investigated...
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Development of an emulation platform for synchronous machine power generation system using a nonlinear functional level model
PublicationThe article presents the Power Hardware in the Loop (PHIL) approach for an autonomous power system analysis based on the synchronous generator model incorporating magnetic saturation effects. The model was prepared in the MATLAB/Simulink environment and then compiled into the C language for the PHIL platform implementation. The 150 kVA bidirectional DC/AC commercial-grade converter was used to emulate the synchronous generator....