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Search results for: biological sample
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Proteomic and Metabolomic Changes in Psoriasis Preclinical and Clinical Aspects
PublicationSkin diseases such as psoriasis (Ps) and psoriatic arthritis (PsA) are immune-mediated inflammatory diseases. Overlap of autoinflammatory and autoimmune conditions hinders diagnoses and identifying personalized patient treatments due to different psoriasis subtypes and the lack of verified biomarkers. Recently, proteomics and metabolomics have been intensively investigated in a broad range of skin diseases with the main purpose...
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What defines excellent lighting design for humans and animals?
PublicationWhat defines excellent lighting design for humans and animals? The answer to the above question is more than complex. It is not enough nowadays to design a project to make it aesthetically pleasing. Nor is it sufficient to create nicely lit environments, or simply to achieve the light levels required by the lighting norms or standards. With the new scientific research of the last few decades that relates directly or indirectly...
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RESIDUE ANALYSIS OF ETU AND PTU BY LC/MS
PublicationDithiocarbamates (DTCs) are important organosulfur compounds, which act as inhibitors of metal dependant and sulphydryl enzymes and have a serious consequence on biological systems. They possess variety of applications in agriculture as fungicides, as well as, in the rubber industry as vulcanization accelerators and antioxidants. In this way, DTCs are the main group of fungicides used to control approximately 400 pathogens of more...
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Multistage treatment wetland for treatment of reject waters from digested sludge dewatering
PublicationThe paper presents the influence of sewage composition on treatment in pilot-scale facility for reject waters (RW) from sewage sludge centrifugation. The facility consisted of mechanical (two tanks with 10 d retention each) and biological parts composed of three subsurface flow reed beds working in batch. Two years of monitoring of the facility proved high efficiency removal of predominant pollutants: COD 75–80%, BOD 82.2–95.5%...
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Capillary Electrophoresis in Determination of Low Molecular Mass Organic Acids
PublicationThis paper presents overviews the capabilities of capillary electrophoretic techniques to determine low molecular mass organic acids in a variety of aqueous, gas and solid samples. It mainly focuses on short - chain carboxylic acids containing one or more carboxylic groups and possibly some other functional groups (hydroxyl, keto-, amino- etc.). Finally the procedures applied to the determine the acids in different matrices are...
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Nonlinear fuzzy control of the dissolved oxygen in activated sludge processes
PublicationWastewater treatment plant is generally a complex, multivariable, time varying and nonlinear large scale industrial system. Moreover, interactions between the components are very strong. The dissolved oxygen tracking problem is one of the most complex and fundamental issues of biological processes. Air for the aerated tanks is supplied by aeration system (blowers, pipes, diffusers). It is a complex dynamic system. The new control...
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Direct measurements of odorous volatile organic compounds present in biosolids cakes by Proton Transfer Reaction – Mass Spectrometry Technique
PublicationThis paper show the results of investigation of concentration of odorous chemical compounds emitted upon ageing of anaerobically stabilised biosolids that could contribute to the overall odour character of nuisance emissions. Biosolids samples from wastewater treatment plant were collected in spring time. Concentrations of volatile organic compounds using a US EPA flux hood and Proton Transfer Reaction-Time of Flight-Mass Spectrometry...
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Recent trends in determination of neurotoxins in aquatic environmental samples
PublicationAnatoxins, saxitoxins, ciguatoxins, beta-N-methylamino-l-alanine and its isomers are groups of neurotoxins which have a highly specific effect on the nervous system of animals, including humans, by interfering with the transmission of nerve impulses. In order to assess the human exposure to these neurotoxins, selective, interlaboratory-validated analytical methods are being developed to facilitate obtaining reliable results on...
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Nitrogen-Doped Diamond Film for Optical Investigation of Hemoglobin Concentration
PublicationIn this work we present the fabrication and characterization of a diamond film which can be utilized in the construction of optical sensors for the investigation of biological samples. We produced a nitrogen-doped diamond (NDD) film using a microwave plasma enhanced chemical vapor deposition (MWPECVD) system. The NDD film was investigated with the use of scanning electron microscopy (SEM), atomic force microscopy (AFM) and Raman...
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Immersive Technologies that Aid Additive Manufacturing Processes in CBRN Defence Industry
PublicationTesting unique devices or their counterparts for CBRN (C-chemical, B-biological, R-radiological, N-nuclear) defense relies on additive manufacturing processes. Immersive technologies aid additive manufacturing. Their use not only helps understand the manufacturing processes, but also improves the design and quality of the products. This article aims to propose an approach to testing CBRN reconnaissance hand-held products developed...
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Task Scheduling – Review of Algorithms and Analysis of Potential Use in a Biological Wastewater Treatment Plant
PublicationThe idea of task scheduling is to increase the efficiency of a system by minimising wasted time, evenly loading machines, or maximising the throughput of machines. Moreover, the use of appropriate scheduling algorithms often leads to a reduction in the energy costs of the process. Task scheduling problems are found in a variety of industrial areas, and their scale changes significantly depending on the problem. This review shows...
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Electrochemically assisted deposition of hydroxyapatite on Ti6Al4V substrates covered by CVD diamond films — Coating characterization and first cell biological results
PublicationAlthough titaniumand its alloys are widely used as implant material for orthopedic and dental applications they show only limited corrosion stability and osseointegration in different cases. The aim of the presented research was to develop and characterize a novel surface modification system from a thin diamond base layer and a hydroxyapatite (HAp) top coating deposited on the alloy Ti6Al4V widely used for implants in contact with bone....
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The relationship between standard reduction potentials of catechins and biological activities involved in redox control
PublicationRedox homeostasis involves factors that ensure proper function of cells. The excess reactive oxygen species (ROS) leads to oxidative stress and increased risk of oxidative damage to cellular components. In contrast, upon reductive stress, insufficient ROS abundance may result in faulty cell signalling. It may be expected that dietary antioxidants, depending on their standard reduction potentials (E°), will affect both scenarios....
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Electrochemical simulation of metabolic reduction and conjugation reactions of unsymmetrical bisacridine antitumor agents, C-2028 and C-2053
PublicationElectrochemistry (EC) coupled with analysis techniques such as liquid chromatography (LC) and mass spectrometry (MS) has been developed as a powerful tool for drug metabolism simulation. The application of EC in metabolic studies is particularly favourable due to the low matrix contribution compared to in vitro or in vivo biological models. In this paper, the EC(/LC)/MS system was applied to simulate phase I metabolism of the representative...
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Marine and Cosmic Inspirations for AI Algorithms
PublicationArtificial Intelligence (AI) is a scientific area that currently sees an enormous growth. Various new algorithms and methods are developed and many of them meets practical, successful applications. Authors of new algorithms draw different inspirations. Probably the most common one is the nature. For example, Artificial Neural Networks were inspired by the structure of human brain and nervous system while the classic Genetic Algorithm...
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Occurrence of Cyanobacteria in the Gulf of Gdańsk (2008–2009)
PublicationBlooms of cyanobacteria develop each summer in the Baltic Sea. Collecting complete data on this phenomenon is helpful in understanding the changes taking place in the Baltic Sea and forecasting the occurrence of these phenomena in the future. This dataset includes unpublished information about the occurrence of cyanobacteria in the Gulf of Gdańsk (Southern Baltic) in 2008 and 2009. The presented data combines basic physic-ochemical...
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Influence of configurations of the beds on contaminations removal in hybrid constructed wetlands.
PublicationThree hybrid constructed wetlands in configuration HF-VF-HF in Poland and one with another configuration VF-HF-Pond in Gremany were analysed. These hybrid constructed wetlands provide the second stage biological treatment. They are located in Pommerania region, in Sarbsk, Wiklino and Wieszyno, and their capacities are 29.7, 18.6 and 24.5 m3/day, respectively. The analysed system in Germany in Waizenfeld (Gemeinde Pommelsbrunn,...
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Strategies for Achieving Energy Neutrality in Biological Nutrient Removal Systems – a Case Study of the Slupsk WWTP (northern Poland)
PublicationThe paper presents a model-based evaluation of technological upgrades on the energy and cost balance in a large biological nutrient removal wastewater treatment plant (WWTP) in the city of Slupsk (northern Poland). The proposed upgrades include chemically enhanced primary sludge removal and reduction of the nitrogen load in the deammonification process employed for reject water treatment. Simulations enabled to estimate the increased...
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Graphene Production and Biomedical Applications: A Review
PublicationGraphene is a two-dimensional nanomaterial composed of carbon atoms with sp2 hybrid orbitals. Both graphene and graphene-based composite have gained broad interest among researchers because of their outstanding physiochemical, mechanical, and biological properties. Graphene production techniques are divided into top-down and bottom-up synthesis methods, of which chemical vapor deposition (CVD) is the most popular. The biomedical...
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Influence of sludge treatment processes on heavy metal speciation
PublicationSludge composition is depending on sewage quality and also affected by processing methods such as thickening, stabilization and dewatering. During those processes some of sludge's undesirable properties might be reduced or enhanced.The objective of the study is the assessment of the influence of sludge processing on selected heavy metals partitioning between phases (aqueous and particle) and sludge. Sludge from the WWTP in Gdansk...
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Synthesis of disubstituted 1,3,4,9-tetrahydropyrano-[3,4-b]indole-1-acetic acids derivatives
Publication1,3,4,9-tetrahydropyrano[3,4-b ]indole-1-acetic acid derivatives are of interest for pharmaceutical research as a core structure for synthesis of biological active substance - Etodolac (selective Cyclooxygenase-2 inhibitor, which belongs to the Non-steroidal Anti-inflammatory Drug, NSAID, that shows a clin-ically effective analgesic and anti-inflammatory activity). Here the way of synthesis of two 1,3,4,9-tetrahydropyrano[3,4-b...
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Evolution of artificial single-cell organisms foraging for resources in a 3-dimensional environment
PublicationForaging for resources is a simple cognitive task that even one-celled biological organisms can ac- complish. We present an Artificial Life system in which artificial unicellular organisms (animats) forage for food in a 3-dimensional simulated liquid environment. The movement of animats is controlled by evolving artificial gene regulatory networks encoded in linear genomes. When an animat consumes enough food, it produces offspring...
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Influence of nitrogen and organic matter fractions on wastewater treatment in treatment wetland
PublicationMunicipal wastewater contains both biodegradable and non-degradable pollutants. Moreover, they are present in dissolved, colloidal and particulate forms. These fractions are characterised by various decomposition rates, hence their bioavailability during microbial respiration. It was confirm that biological degradation rate in terms of COD reduction is influenced by particle size speciation. Therefore, the objective of the study...
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DO WE NEED NAVIER NUMBER? – FURTHER REMARKS AND COMPARISON WITH ANOTHER DIMENSIONLESS NUMBERS
PublicationThis paper presents a role of the Navier number (Na-dimensionless slip-length) in universal modelling of flow reported in micro- and nano-channels like: capillary biological flows, fuel cell systems, micro-electro-mechanical systems and nano-electro-mechanical systems. Similar to another bulk-like and surface-like dimensionless numbers, the Na number should be treated as a ratio of internal viscous to external viscous momentum...
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IMPACT OF DIRECT CURRENT ON NITRIFYING BIOMASS
PublicationEffects of short term exposure of nitrifying biomass to direct current were studied. DC was applied to mixed liquor from municipal BNR plant using graphite electrodes in no substrate limiting conditions. Both, ammonia oxidizing bacteria (AOB) and nitrite oxidizing bacteria (NOB) populations were affected by the current, however in opposite ways. The AOB population activity was inhibited by applied voltage. Activity decrease was...
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Effects of Laser Remelting at Cryogenic Conditions on Microstructure and Wear Resistance of the Ti6Al4V Alloy Applied in Medicine
PublicationThe titanium and its alloys can be subjected to surface treatment, including laser treatment. In this work a new laser treatment at cryogenic conditions of Ti6Al4V alloy has been described. The work has been aimed at establishing whether such surface treatment could be suitable for implants working under wear in biological corrosive environment. The remelting has been made with the use of CO2 continuous work laser at laser power...
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Spectral measurement of birefringence using particle swarm optimization analysis
PublicationThe measurement of birefringence is useful for the examination of both technical and biological objects. One of the main problems is that the polarization state of light in birefringent media changes periodically. Without the knowledge of the period number, the birefringence of a given medium cannot be determined reliably. We propose to analyse the spectrum of light in order to determine the birefringence. We use a Particle Swarm...
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Balancing Energy Inputs/Outputs and GHG Emissions for Sustainable Wastewater Treatment – a Case Study
PublicationThe aim of the study is a model-based evaluation of the selected operating modes and technological upgrades on the energy balance and greenhouse gas (GHG) emissions in a large wastewater treatment plant in the city of Slupsk (northern Poland). The considered scenarios focus on energy savings for aeration, increasing energy recovery via biogas cogeneration and reduction of the CO2 equivalent emission from both direct processes (related...
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Aminy w środowisku - niebezpieczeństwo czy jego naturalny element?
PublicationA lot of amines and their compounds are used in the industry. First of all they are used for the preparation of medicines, plant protection agents, fertilizers and plastics. Amines are also released into the environment as a result of natural biological processes such as the release of certain species of flowers to lure insects, and also biochemical breakdown of amino acids in the protein during decomposition of organic matter. Unfortunately,...
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Strategies for achieving energy neutrality in biological nutrient removal systems - a case study of the Slupsk WWTP (northern Poland)
PublicationThe paper presents a model-based evaluation of technological upgrades on the energy and cost balance in a large biological nutrient removal wastewater treatment plant (WWTP) in the city of Slupsk (northern Poland). The proposed upgrades include chemically enhanced primary sludge removal and reduction of the nitrogen load in the deammonification process employed for reject water treatment. Simulations enabled to estimate the increased...
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Offshore surface waters of Antarctica are free of microplastics, as revealed by a circum-Antarctic study
PublicationIn 2018, during a circum navigation of Antarctica below 62° S by the sailing boat Katharsis II, the presence of plastics was investigated with surface sampling nets at ten evenly spaced locations (every 36° of longitude). Although fibres that appeared to be plastic (particles up to 2 cm) were found in numbers ranging from 1 particle (0.002 particles per m3) to 171 particles (1.366 particles per m3) per station, a Fourier-transform...
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Quantum Coherence as a Resource
PublicationThe coherent superposition of states, in combination with the quantization of observables, represents one of the most fundamental features that mark the departure of quantum mechanics from the classical realm. Quantum coherence in many-body systems embodies the essence of entanglement and is an essential ingredient for a plethora of physical phenomena in quantum optics, quantum information, solid state physics, and nanoscale thermodynamics....
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State of the art and prospects of methods for determination of lipophilicity of chemical compounds
PublicationLipophilicity of the compounds is useful to (i) explain their distribution in biological systems, which is different in plant and in animal organisms, (ii) predict the possible pathways of pollutant transport in the environment, and (iii) support drug discovery process and select optimal composition in terms of bioactivity and bioavailability. The lipophilic properties can be determined by two main approaches, experimental, which...
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Towards Cancer Patients Classification Using Liquid Biopsy
PublicationLiquid biopsy is a useful, minimally invasive diagnostic and monitoring tool for cancer disease. Yet, developing accurate methods, given the potentially large number of input features, and usually small datasets size remains very challenging. Recently, a novel feature parameterization based on the RNA-sequenced platelet data which uses the biological knowledge from the Kyoto Encyclopedia of Genes and Genomes, combined with a classifier...
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Modeling the Structure, Dynamics, and Transformations of Proteins with the UNRES Force Field
PublicationThe physics-based united-residue (UNRES) model of proteins ( www.unres.pl ) has been designed to carry out large-scale simulations of protein folding. The force field has been derived and parameterized based on the principles of statistical-mechanics, which makes it independent of structural databases and applicable to treat nonstandard situations such as, proteins that contain D-amino-acid residues. Powered by Langevin dynamics...
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The effect of Sr and Mg substitutions on structure, mechanical properties and solubility of fluorapatite ceramics for biomedical applications
PublicationIonic substitutions play important role in the modifications of biological apatites. Recently, attention has been focused on the co-doping effects on the functional properties of apatite-based biomaterials. In this research work, the dense samples of fluorapatites, Ca10(PO4)6F2 and Ca8MgSr(PO4)6F2, were produced after sintering at 1250 °C for 6 h in air. Structural characterization carried out with XRD, IR, Raman and SEM, confirmed...
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A Simple Replica Method as the Way to Obtain a Morphologically and Mechanically Bone-like Iron-Based Biodegradable Material
PublicationPorous iron-based scaffolds were prepared by the simple replica method using polyurethane foam as a template and applying the sintering process in a tube furnace. Their surface morphology was characterized using scanning electron microscopy (SEM) and phase homogeneity was confirmed using X-ray diffraction (XRD). Corrosion behavior was determined using immersion and potentiodynamic polarization methods in phosphate buffered saline...
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Biomimetic torene shells
PublicationThe genome inside the eukaryotic cells is guarded by a unique shell structure, called the nuclear envelope (NE), made of lipid membranes. This structure has an ultra torus topology with thousands of torus-shaped holes that imparts the structure a high flexural stiffness. Inspired from this biological design, here we present a novel ‘‘torene’’ architecture to design lightweight shell structures with ultra-stiffness for engineering...
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Chemical and biological stability of polyene macrolides
PublicationThe polyene macrolide antibiotics have been used in an-tifungal therapy since first o f them were discovered in 1950's. Up to now, four polyene macrolides are being used in medical practice, namely amphotericin B, nystatin, candi-cidin and pimaricin.The antifungal activity and mode of ac-tion of polyene macrolides is determined by their structure, chemical and physical properties.The main fragment of polyene...
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Water chemistry of tundra lakes in the periglacial zone of the Bellsund Fiord (Svalbard) in the summer of 2013
PublicationClimate changes observed in the Arctic (e.g. permafrost degradation, glacier retreat) may have significant influence on sensitive polar wetlands. The main objectives of this paper are defining chemical features of water within six small arctic lakes located in Bellsund (Svalbard) in the area of continuous permafrost occurrence. The unique environmental conditions of the study area offer an opportunity to observe phenomena influencing...
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Recent Issues and Challenges in the Study of Inland Waters
PublicationThis paper addresses several important problems and methods related to studies of inland waters based on the existing scientific literature. The use of UAVs in freshwater monitoring is described, including recent contact and non-contact solutions. Due to a decline in biological diversity in many parts of the globe, the main threats are described together with a modern method for algae and cyanobacteria monitoring utilizing chlorophyll...
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Molecularly imprinted polymers based on deep eutectic solvents as a greenest materials for selective extraction of emerging contaminants from complex samples
PublicationSome of the reagents applied in the synthesis of molecularly imprinted polymers (MIPs) may impact on health and the environment. Thus, a new generation of promising green chemicals are nowadays introduced and investigated, including deep eutectic solvents (DESs). DESs seems to be a reasonable choice as they are characterized as non-toxic, low cost, easy to prepare and biodegradable chemicals. This review presents the information...
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Occurrence and Determination of Volatile Fatty Acids in Landfill Leachate and Gas
PublicationIn landfills containing biological matter volatile fatty acids (VFAs) are generated at high rate at the early stage of waste disposal and their content in leachate is high as compared to the leachate from old parts of landfill since they are converted to methane gas. Monitoring of the leachate for the content of VFAs can help determine the processes occurring in waste and possible effect of the leachate on the environment in the...
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Occurrence and Determination of Volatile Fatty Acids in Landfill Leachate and Gas
PublicationIn landfills containing biological matter volatile fatty acids (VFAs) are generated at high rate at the early stage of waste disposal and their content in leachate is high as compared to the leachate from old parts of landfill since they are converted to methane gas. Monitoring of the leachate for the content of VFAs can help determine the processes occurring in waste and possible effect of the leachate on the environment in the...
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Types of wear and tear of biomaterials used in orthopaedic surgery
PublicationPurpose of this paper is presentation of observations on different kinds of wear and tear of biomaterials used in contemporary orthopaedic surgery. Types of prosthesis damage, encountered in medical practice, and their causes have been described. Results of many clinical studies were analysed to review prosthesis damage from the stage of implanting (such as intrusion of a foreign object between its components) to their natural...
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Removal of Pharmaceutically Active Compounds in Sequencing Batch Reactor
PublicationIn recent years, considerable attention was paid to the presence of organic micro-pollutants such as Active Pharmaceutical Ingredients (API) in the aquatic environment due to their negative impact on public health and aquatic ecosystems. Numerous papers have pointed out API presence as common constituents of effluents from Wastewater Treatment Plants (WWTPs). This is the result of various efficiencies of API removal by conventional...
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Pilot study of the influence of thermoplastic starch based polymer packaging material on the growth of diatom population in sea water environment
PublicationNovel polymeric packaging materials susceptible to environmentally friendly decomposition appeared on the global market. The paper is devoted to an investigation of the impact of degradable polymer packaging on marine life. The chosen polymer was a commercial packaging based on thermoplastic starch (TPS over 85%). The microorganism chosen was Phaeodactylum tricornutum diatom (identified in many aquatic reservoirs, with a tendency...
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Computational methods for calculation of binding free energy for ligand-receptor complexes
PublicationAccurate description of the molecular complexes energetic influence is required for understanding of many biological functions carried out by proteins. Therefore, estimation of binding free energy for ligand-receptor complexes is of highest importance for structure-based ligand design and drug discovery approaches.Experimental methods of determination of difference in Gibbs'es free energy have many limitations. Thus, computational...
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The role of analytical chemistry in the study of the Anthropocene
PublicationThe term “Anthropocene” refers to not yet formalized epoch of geologic time during which geologic processes have been dominated by the human impact. This impact takes on many forms. Biological, physical and chemical changes to the Earth System caused by anthropogenic activity are recorded in natural archives either as new fossil assemblages (neobiota), anthropogenic deposits or a wide variety of pollutants emitted to the environment....
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Solubilization of keratins and functional properties of their isolates and hydrolysates
PublicationThe keratinous wastes of the textile industry and poultry slaughterhouses may be used as sources of soluble keratins or hydrolysates. This review presents methods for processing raw keratin-based materials into bioproducts with functional and bioactive properties suitable for biomedical, cosmetic, food, and agricultural applications. Soluble keratin can be obtained by thermal treatment in some organic solvents, reduction, or oxidation...