Filters
total: 4011
filtered: 961
Search results for: HUNTINGTON’S DISEASE
-
Evaluation of the Electronic Nose Used for Monitoring Environmental Pollution
PublicationAir pollution is a one of the major concern of civilized world, which has a significant impact on human health and the environment. Recent studies highlight that the exposure to polluted air can increase the incidence of diseases and deteriorate the quality of life. Hence, it is necessary to develop tools for real-time air quality monitoring. Electronic-nose systems based on sensors are an interesting and promising technology in...
-
Indoor air quality in public utility environments-a review
PublicationIndoor air quality has been the object of interest for scientists and specialists from the fields of science such as chemistry, medicine and ventilation system design. This results from a considerable number of potential factors, which may influence the quality of the broadly understood indoor air in a negative way. Poor quality of indoor air in various types of public utility buildings may significantly affect an increase in the...
-
A review on fungal-based biopesticides and biofertilizers production
PublicationThe escalating use of inorganic fertilizers and pesticides to boost crop production has led to the depletion of natural resources, contamination of water sources, and environmental crises. In response, the scientific community is exploring eco-friendly alternatives, such as fungal-based biofertilizers and biopesticides, which have proven effectiveness in enhancing plant health and growth while sustainably managing plant diseases...
-
Modeling emotions for affect-aware applications
PublicationThe chapter concerns emotional states representation and modeling for software systems, that deal with human affect. A review of emotion representation models is provided, including discrete, dimensional and componential models. The paper provides also analysis of emotion models used in diverse types of affect-aware applications: games, mood trackers or tutoring systems. The analysis is supported with two design cases. The study...
-
Special Issue "Applications of Finite Element Modeling for Mechanical and Mechatronic Systems"
PublicationNumerical modeling is very important in today's engineering because, among other things, it reduces the costs associated with prototyping or predicting the occurrence of potentially dangerous situations during operation in certain defined conditions. Different methods have so far been used to implement the real structure into the numerical version. The most popular have been variations of the finite element method (FEM). The aim...
-
Zdolności dynamiczne do budowania chmury wartości w modelach biznesów
PublicationObserwacja współczesnych metod tworzenia wartości daje podstawy do wyłonienia nowej logiki ich generowania. Analiza modeli wytwarzania wartości przez przedsiębiorstwa np. sieciowe wykazała, że formułują one chmury wartości. Struktury tych chmur są różnorodne, niejednolite, kłębiaste. Przeprowadzone prace pozwoliły na sformułowanie obrazów wartości generowanych przez twarde komponenty modeli biznesów. Osiągnięcie tych wyników pozwoliło...
-
Detection of Toxoplasma gondii in meat - available techniques
PublicationToxoplasma gondii, which belongs to the phylum Apicomplexa, is an absolute intercellular parasite that infects a wide range of hosts, including warm-blooded animals and humans. An infection with this parasite causes toxoplasmosis, which in most cases remains latent. However, this disease is a major threat to immunocompromised people and pregnant women. In extreme cases, it can damage nervous system or case fatal abortion. Infected...
-
Epidemiological study of Toxoplasma gondii infection among cattle in Northern Poland
PublicationToxoplasmosis, caused by Toxoplasma gondii, is a significant disease in livestock and humans. Because of medical and veterinary importance it is essential to study the prevalence of T. gondii infection among human and animals in various parts of the word. In this study, 4033 cattle from eight provinces of Northern Poland (belonging to 190 herds) were tested for IgG antibodies against T. gondii by an in-house ELISA technique based...
-
IgG Avidity Test as a Tool for Discrimination between Recent and Distant Toxoplasma gondii Infection—Current Status of Studies
PublicationToxoplasma gondii, an obligate intracellular protozoan parasite, is the causative agent of one of the most prevalent zoonoses worldwide. T. gondii infection is extremely important from a medical point of view, especially for pregnant women, newborns with congenital infections, and immunocompromised individuals. Thus, an accurate and proper diagnosis of this infection is essential. Among the available diagnostic tests, serology...
-
Borrelia burgdorferi BmpA-BBK32 and BmpA-BBA64: New Recombinant Chimeric Proteins with Potential Diagnostic Value
PublicationCurrently, the diagnosis of Lyme disease is based mostly on two-tiered serologic testing. In the new generation of immunoenzymatic assays, antigens comprise whole-cell lysates of members of the Borrelia burgdorferi sensu lato (s.l.) species complex, with the addition of selected recombinant proteins. Due to the high diversity of members of the B. burgdorferi s.l. genospecies and the low degree of conservation among the amino acid...
-
Detection of Toxoplasma gondii Infection in Small Ruminants: Old Problems, and Current Solutions
PublicationToxoplasmosis is a parasitic zoonosis of veterinary importance, with implications for public health. Toxoplasma gondii infection causes abortion or congenital disease in small ruminants. Moreover, the consumption of infected meat, cured meat products, or unpasteurized milk and dairy products can facilitate zoonotic transmission. Serological studies conducted in various European countries have shown the high seroprevalence of specific...
-
Forewarned Is Forearmed: Machine Learning Algorithms for the Prediction of Catheter-Induced Coronary and Aortic Injuries
PublicationCatheter-induced dissections (CID) of coronary arteries and/or the aorta are among the most dangerous complications of percutaneous coronary procedures, yet the data on their risk factors are anecdotal. Logistic regression and five more advanced machine learning techniques were applied to determine the most significant predictors of dissection. Model performance comparison and feature importance ranking were evaluated. We identified...
-
A rapid-response ultrasensitive biosensor for influenza virus detection using antibody modified boron-doped diamond
PublicationAccording to the World Health Organization (WHO), almost 2 billion people each year are infected worldwide with flu-like pathogens including influenza. This is a contagious disease caused by viruses belonging to the family Orthomyxoviridae. Employee absenteeism caused by flu infection costs hundreds of millions of dollars every year. To successfully treat influenza virus infections, detection of the virus during the initial development...
-
Primary degradation of antidiabetic drugs
PublicationType 2 diabetes is a chronic disease affecting a large portion of the world population and is treated by orally administered drugs. Since these drugs are often taken in high doses and are excreted unchanged or partially metabolised many of them are nowadays detected in surface waters or wastewater treatment plants effluents. Unmetabolised antidiabetics or some of their transformation products retain their pharmacological activity,...
-
Telomere uncapping by common oxidative guanine lesions: Insights from atomistic models
PublicationOxidative damage to DNA is widely known to contribute to aging and disease. This relationship has been extensively studied for telomeres – structures that cap chromosome ends – due to their role in cell proliferation and senescence, and exceptional susceptibility to oxidation. Indeed, the repetitive telomeric DNA sequence contains the 5′-GGG-3′ motif that has the lowest ionization potential of all trinucleotides. Accordingly, experiments...
-
Enhancing colloidal stability of nanodiamond via surface modification with dendritic molecules for optical sensing in physiological environments
PublicationPre-treatment of diamond surface in low-temperature plasma for oxygenation and in acids for carboxylation was hypothesized to promote the branching density of the hyperbranched glycidol polymer. This was expected to increase the homogeneity of the branching level and suppress interactions with proteins. As a result, composite nanodiamonds with reduced hydrodynamic diameters that are maintained in physiological environments were...
-
Biology, systematics, and clinical manifestations of Zygomycota infections
Publication -
Association between susceptibility to photodynamic oxidation and the genetic background of Staphylococcus aureus
Publication -
A subset of two adherence systems, acute pro-inflammatory pap genes and invasion coding dra, fim, or sfa, increases the risk of Escherichia coli translocation to the bloodstream
PublicationAn analysis of the phylogenetic distribution and virulence genes of Escherichia coli isolates which predispose this bacteria to translocate from the urinary tract to the bloodstream is presented. One-dimensional analysis indicated that the occurrence of P fimbriae and α-hemolysin coding genes is more frequent among the E. coli which cause bacteremia. However, a two-dimensional analysis revealed that a combination of genes coding...
-
Leukemia and risk of recurrent Escherichia coli bacteremia: genotyping implicates E. coli translocation from the colon to the bloodstream.
PublicationIn patients with leukemia, the portal(s) and reasons for the persistence of an Escherichia coli recurrent bacteremia remain unclear. Adult Hematology Clinic (AHC) databases at the State Clinical Hospital in Gdańsk were reviewed to evaluate the frequency of E. coli bacteremia between 2002 and 2005. Blood and bowel E. coli strains were obtained and the genetic relatedness of the strains was analyzed. The rate of E. coli bacteremia...
-
Characterisation of Escherichia coli isolates from the blood of haematological adult patients with bacteraemia: translocation from gut to blood requires the cooperation of multiple virulence factors
PublicationThe aim of the study was to investigate whether there are unique pathotypes of Escherichia coli capable of transmission from the gastrointestinal tract to the vascular bed. The study included E. coli strains isolated from clinical materials collected from 115 patients suffering from haematologic malignancies diagnosed with bacteraemia. The genotyping techniques established that 89 E. coli isolates from the blood had the same genotype...
-
Lipid peroxidation products as potential bioindicators of Lyme arthritis
Publication -
Children were less frequently infected with SARS-CoV-2 than adults during 2020 COVID-19 pandemic in Warsaw, Poland
Publication -
Retrospective analysis of genetic diversity of Klebsiella oxytoca isolated in Poland over a 50-year period.
PublicationAnaliza genetyki populacji i określenie powiązań filogenetycznych pomiędzy szczepami może być niezwykle użytecznym podejściem w określaniu rozprzestrzeniania się wzorów genetycznych różnych gatunków bakterii na potrzeby epidemiologiczne. Nie ma danych, które opisywałyby długoterminowe sytuacje epidemiologiczne powodowane przez wielolekooporne, oportunistyczne szczepy Klebsiella oxytoca metodami molekularnymi. Celem przedstawionych...
-
Biodegradable polymer packaging materials - influence on environment
PublicationAwareness of the waste problem and its impact on the environment has awakened new interest in the area of biodegradable polymers. Biodegradation of various polymers have been studied under diverse environments like in soil, in sewage sludge, in compost conditions and in sea water by different research groups. The aim of this paper is to present the research methods on the biodegradation of the commercially available biodegradable...
-
A competition between two- and three-body dissociation channels in photo-double-ionization of tetrahydro-2H-pyran and 3,4-dihydro-2H-pyran molecules
PublicationVarious molecules possess structures consisting of the heterocyclic rings containing oxygen atoms. These substances often play a significant role in many different fields of chemistry, medicine, and biology. Due to a specific atomic composition and bond arrangement, many of these molecules retain unique electronic properties, which may be probed by diverse spectroscopic techniques, including those utilizing synchrotron radiation....
-
Fast Fading Influence on the Deep Learning-Based LOS and NLOS Identificationin Wireless Body Area Networks
PublicationIn the article, the fast fading influence on the proposed DL (Deep Learning) approach for LOS (Line-of-Sight) and NLOS (Non-Line-of-Sight) conditions identification in Wireless Body Area Networks is investigated. The research was conducted on the basis of the off-body communication measurements using the developed mobile measurement stand, in an indoor environment for both static and dynamic scenarios. The measurements involved...
-
SUBIEKTYWNE POSTRZEGANIE RÓŻNORODNOŚCI ZESPOŁU – PERSPEKTYWA MENADŻERA
PublicationZarządzanie zespołami zróżnicowanymi powinno przejawiać się aktywnym i świadomym działaniem prowadzącym do pełnego wykorzystania potencjału zespołu. To, czy potencjał ten zostanie wykorzystany, zależy od wielu czynników. Wydaje się, że jednym z najważniejszych jest nie tyle rzeczywiste,obiektywne zróżnicowanie członków zespołu, ile to, w jaki sposób różnorodność ta jest subiektywnie postrzegana. Artykuł przedstawia wyniki badań...
-
Testing and sampling devices for monitoring volatile and semi-volatile organic compounds in indoor air
PublicationAdults spend most of their time in enclosed spaces (e.g., apartment, office and public buildings). According to research conducted by scientists, air quality indoors is much worse than the ambient air quality outdoors. Hazardous chemicals found in air indoors can adversely affect the functioning of the human body and cause many respiratory and circulatory diseases. Harmful chemical compounds (mainly volatile organic compounds and...
-
Isoprostanes-Biomarkers of Lipid Peroxidation: Their Utility in Evaluating Oxidative Stress and Analysis
PublicationIsoprostanes (IsoPs) are key biomarkers for investigating the role of free radical generation in the pathogenesis of human disorders. To solve IsoPs-related problems with regard to isoprostanes, analytical tools are required. This paper reviews the problems and trends in this field focusing on the methodology for assaying biomarkers in exhaled breath condensate (EBC) samples. A large amount of work has been done in the qualitative...
-
Anatomy of noise in quantitative biological Raman spectroscopy
PublicationRaman spectroscopy is a fundamental form of molecular spectroscopy that is widely used to investigate structures and properties of molecules using their vibrational transitions. It relies on inelastic scattering of monochromatic laser light irradiating the specimen. After appropriate filtering the scattered light is dispersed onto a detector to determine the shift from the excitation wavelength, which appears in the form of...
-
Explicit solvent repulsive scaling replica exchange molecular dynamics ( RS‐REMD ) in molecular modeling of protein‐glycosaminoglycan complexes
PublicationGlycosaminoglcyans (GAGs), linear anionic periodic polysaccharides, are crucial for many biologically relevant functions in the extracellular matrix. By interacting with proteins GAGs mediate processes such as cancer development, cell proliferation and the onset of neurodegenerative diseases. Despite this eminent importance of GAGs, they still represent a limited focus for the computational community in comparison to other classes...
-
Adaptive stochastic and hybrid nonlinear optimization algorithms for improving the effectiveness of the biological processes at WWTP
PublicationWastewater treatment plays an important factor in the modern world. Insufficient treatment may result in environmental pollution which can further lead to disasters and diseases. However, processes that take place inside wastewater treatment plants (WWTP) are highly complex in nature, therefore it is difficult to design an efficient, optimal control system. The problem regarding biochemical reactions inside Sequential Batch Reactor...
-
Polylysine for Skin Regeneration: A Review of Recent Advances and Perspectives
PublicationThere have been several attempts to find promising biomaterials for skin regeneration, among which polylysine (a homopolypeptide) has shown benefits in the regeneration and treatment of skin disorders. This class of biomaterials has shown exceptional abilities due to their macromolecular structure. Polylysine-based biomaterials can not only be used as tissue engineering scaffolds for skin regeneration, but also as drug carriers...
-
CyberEye: New Eye-Tracking Interfaces for Assessment and Modulation of Cognitive Functions beyond the Brain
PublicationThe emergence of innovative neurotechnologies in global brain projects has accelerated research and clinical applications of BCIs beyond sensory and motor functions. Both invasive and noninvasive sensors are developed to interface with cognitive functions engaged in thinking, communication, or remembering. The detection of eye movements by a camera offers a particularly attractive external sensor for computer interfaces to monitor,...
-
Fluid–Structure Interaction methods for the progressive anatomical and artificial aortic valve stenosis
PublicationCardiovascular system diseases, as aortic valve stenosis, are the main cause of mortality and morbidity among patients. There is still a room for enhancement of the diagnostic and therapeutic procedures, which will lead to improvement of the treatment. One of the remedies are the computer tools to support the medical diagnoses and prostheses design. The development of a procedure for modeling the aortic valves: anatomical tricuspid...
-
Application of 3D Whole Body Scanning in Research on Human Body Surface Area
PublicationHuman body surface area (BSA) is one of the major parameters used in several medical fields. Its heterogeneity caused by individual human characteristics sustains a many-decades-long research on the matter. Today’s technology allows to create exact body models in mere seconds. However, an extensive research that includes scanning people with major disfigurements or people suffering from diseases, which often prevent their mobility,...
-
Transdermal transport of collagen and hyaluronic acid using water in oil microemulsion
PublicationCollagen and hyaluronic acid (HA) are biopolymers that affect the appearance and condition of the skin. Delivery of these compounds into the skin is highly challenging since have a number of disadvantageous properties, such as high molecular weight and hydrophilicity. Here, we evaluated the transdermal penetration of low and high molecular weight collagen and HA from microemulsions. A number of microemulsion formulations, differing...
-
An additional ultrasonographic sign of Hashimoto’s lymphocytic thyroiditis in children
PublicationWe present an additional sonographic sign of Hashimoto’s thyroiditis (HLT), increasing the specifi city of this method in pediatric populations. Methods: A total of 98 children (mean age 12.7 years, range 7–17 years) were selected from the registry of the endocrinology outpatient department. All subjects met the diagnostic criteria for HLT. All children underwent a prospective thyroid ultrasound examination with special attention...
-
Results from a Genome-Wide Association Study (GWAS) in Mastocytosis Reveal New Gene Polymorphisms Associated with WHO Subgroups
PublicationMastocytosis is rare disease in which genetic predisposition is not fully understood. The aim of this study was to analyze associations between mastocytosis and single nucleotide polymorphisms (SNPs) by a genome-wide association study (GWAS) approach. A total of 234 patients were enrolled in our study, including 141 with cutaneous mastocytosis (CM; 78 children and 63 adults) and 93 with systemic mastocytosis (SM, all adults)....
-
Mining Knowledge of Respiratory Rate Quantification and Abnormal Pattern Prediction
PublicationThe described application of granular computing is motivated because cardiovascular disease (CVD) remains a major killer globally. There is increasing evidence that abnormal respiratory patterns might contribute to the development and progression of CVD. Consequently, a method that would support a physician in respiratory pattern evaluation should be developed. Group decision-making, tri-way reasoning, and rough set–based analysis...
-
Total impact of oxidative stress genes on cardiovascular events—a 7-year follow-up study
PublicationCardiovascular (CV) events are the number one cause of lifetime disability and deaths worldwide. It is well known that traditional risk factors do not fully correlate with clinical outcomes; therefore, searching for other markers that would explain CV events occurrence seems essential. Of importance, one of the main factors at the origin of CV events is oxidative stress, causing inflammation and atherosclerotic plaque instability....
-
COVID‐19: A systematic review and update on prevention, diagnosis, and treatment
PublicationSince the rapid onset of the COVID-19 or SARS-CoV-2 pandemic in the world in 2019, extensive studies have been conducted to unveil the behavior and emission pattern of the virus in order to determine the best ways to diagnosis of virus and thereof formulate effective drugs or vaccines to combat the disease. The emergence of novel diagnostic and therapeutic techniques considering the multiplicity of reports from one side and contradictions...
-
Antimicrobial Activity of Honey
PublicationHoney has had a valued place in traditional medicine for centuries. It was used to overcome liver, cardiovascular and gastrointestinal problems and for treatment of some types of infectious disease. Particularly, good results were achieved in the case of application of this product for therapy of infected, difficult to heal wounds. The high health-promoting properties of honey have been recently confirmed in many research investigations....
-
Application of the Electronic Nose Technique to Differentiation between Model Mixtures with COPD Markers
PublicationABSTRACT The paper presents the potential of an electronic nose technique in the field of fast diagnostics of patients suspected of Chronic Obstructive Pulmonary Disease (COPD). The investigations were performed using a simple electronic nose prototype equipped with a set of six semiconductor sensors manufactured by FIGARO Co. They were aimed at verification of a possibility of differentiation between model reference mixtures with...
-
Toxoplasma gondii Recombinant antigen AMA1: Diagnostic Utility of Protein Fragments for the Detection of IgG and IgM Antibodies
PublicationToxoplasma gondii is an important zoonotic protozoan that infects a wide variety of vertebrates as intermediate hosts. For this reason, the diagnosis of this disease is very important and requires continuous improvement. One possibility is to use recombinant antigens in serological tests. Apical membrane antigen 1 (AMA1), a protein located in specific secretory organelles (micronemes) of T. gondii, is very interesting in regard...
-
Tunable Dielectric Switching of (Quinuclidinium)[MnCl4] Hybrid Compounds
PublicationInorganic−organic hybrid QMnCl (Q = quinuclidinium) crystals were synthesized and characterized. The X-ray and variable-temperature IR/Raman analysis demonstrate that the crystals undergo a reversible structural phase transition, which originates from an order−disorder process and is related to the dynamics of the organic Q cation. Dielectric function measurements disclose a switchability between low (“OFF”) and high (“ON”) dielectric...
-
Azo group(s) in selected macrocyclic compounds
PublicationAzobenzene derivatives due to their photo- and electroactive properties are an important group of compounds finding applications in diverse fields. Due to the possibility of controlling the trans–cis isomerization, azo-bearing structures are ideal building blocks for development of e.g. nanomaterials, smart polymers, molecular containers, photoswitches, and sensors. Important role play also macrocyclic compounds well known for...
-
PUBLIC SPACES FOR LOCAL LIFE / Shared values in diversified urban communities as a foundation for participatory provision of local public spaces, 23-27 May 2017, Ljubljana Slovenia
PublicationThe Urban Planning Institute of the Republic of Slovenia (UIRS) and partners hosted a 5-day international event addressing participatory planning of local urban public space in socially, economically and ethnically diverse communities. The event was structured in three interrelated activities: a seminar, a workshop and a field-trip. Special emphasis was given to the means of revealing shared values that local inhabitants and other...
-
Blue-berried honeysuckle a promising cancer preventing fruit; Polish genotypes as a source of bioactive phytochemicals
PublicationFrom the ancient times, plants containing health-oriented compounds in their matrices are used in the treatment of different complaints and diseases. One of these groups are plant secondary metabolites (PSM), especially phenolic compounds, terpenes and terpenoids. A large number of PSM exhibit cytotoxicity against a variety of tumor cells, as well as cancer preventive and anticancer efficacy in preclinical animal models. For this...