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Search results for: Androgen receptor
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Alternative methods for dark fermentation course analysis
PublicationDark fermentation course analysis is crucial, as complexed matrix of gaseous components may be formed and revealed during the process. The paper considers key issues related to the microbiological process in which complex organic substances are transformed into hydrogen. For the purposes of hydrogen generation, the application of wastewater mixed sludge pre-treated according to Faloye method (Faloye et al. in Int J Hydrog Energy...
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Do Phenyl Substituents Affect the Properties of Azobenzocrown Derivatives?
PublicationNew products of photo- and thermal rearrangements of 19-membered azoxybenzocrown with phenyl substituents in benzene rings in the para positions to oligooxyethylene fragments are characterized. The yields of photochemical transformations depend on the solvent. Para-hydroxyazocrown is formed with yields over 50% in propan-2-ol. Ortho-hydroxyazobenzocrown is obtained with yields up to 70% in toluene/acetic acid mixture. Macrocyclic...
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Evaluation of Three Peptide Immobilization Techniques on a QCM Surface Related to Acetaldehyde Responses in the Gas Phase
PublicationThe quartz-crystal microbalance is a sensitive and universal tool for measuring concentrations of various gases in the air. Biochemical functionalization of the QCM electrode allows a label-free detection of specific molecular interactions with high sensitivity and specificity. In addition, it enables a real-time determination of its kinetic rates and affinity constants. This makes QCM a versatile bioanalytical screening tool for...
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Speace frienly for the blind = Przestrzeń przyjazna dla niewidomych
PublicationThe article presents issues connected with accessibility of public space for people with eyesight disabilities. The use of the extravisual spatial stimuli in shaping the urban environment has been analysed. Spaces in which musltisensory spatial reception is feasible become user-friendly, as they come to meet the changing needs of their users. The article introduces a system of textures aiding spatial orientation, navigation and...
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Photophysics and Halide Quenching of Soret-excited ZnTPPS4- in Aqueous Media
PublicationSteady state S2-S0 and S1-S0 absorption and emission spectra and picosecond S2 decay and S1 fluorescence rise times have been measured for the model porphyrin ZnTPPS4− in water and in aqueous iodide solutions of constant ionic strength. The dynamics of S1 quenching by iodide are well-modeled by a Stern-Volmer mechanism yielding kQ = 1.75 × 109 M−1 s−1. The S2 state is quenched on a ps time scale by a static electron-transfer mechanism...
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Preparation and X-ray structures of selected aminium thiosulfates
PublicationVarious types of aminium thiosulfates (1–6), including hydrates and mixed salts, have been obtained by the reaction of ammonium thiosulfate with amines. Tertbutylamine, cyclo-hexylamine and 1,6-diaminohexane gave crystals of (t-BuNH3)2S2O3·H2O (1), (c-C6H11NH3)2S2O3 (3) and {(NH4)2(H3NC6H12NH3)(S2O3)2} (6), respectively, which were investigated by X-ray structural analysis. Extensive hydrogen bonding of the N-H…O and N-H…S type...
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Zaawansowane utlenianie odcieków składowiskowych - przegląd metod
PublicationPrzedstawiono rozwiązania unieszkodliwiania odcieków składowiskowych metodami zaawansowanego utleniania, takimi jak: reakcja Fentona, utlenienie ozonem i nadtlenkiem wodoru, utlenienie elektrochemiczne, utlenienie w warunkach nadkrytycznych oraz mokre utlenienie powietrzem. Podstawy teoretyczne tych metod, ich efektywność oraz stosowane reagenty. Uwarunkowania stosowania poszczególnych metod.
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Interactions of protons with furan molecules studied by collision-induced emission spectroscopy at the incident energy range of 50–1000 eV
PublicationInvestigations of the ion-molecule reactions provide insight into many fields ranging from the stellar wind interaction with interstellar media, up to medicine and industrial applications. Besides the applications, the understanding of these processes is itself a problem of fundamental importance. Thus, interactions of protons with the gas-phase furan molecules have been investigated for the first time in the energy range of 50–1000...
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Effect of Nanohydroxyapatite on Silk Fibroin–Chitosan Interactions—Molecular Dynamics Study
PublicationFibroin–chitosan composites, especially those containing nanohydroxyapatite, show potential for bone tissue regeneration. The physicochemical properties of these biocomposites depend on the compatibility between their components. In this study, the intermolecular interactions of fibroin and chitosan were analyzed using a molecular dynamics approach. Two types of systems were investigated: one containing acetic acid and the other...
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Automatic tuning of a resonant circuit in wireless power supply systems for biomedical sensors
PublicationIn this paper, a tuning method of a resonant circuit suited for wireless powering of miniature endoscopic capsules is presented and discussed. The method allows for an automatic tuning of the resonant frequency and matching impedance of a full wave rectifier loading the resonant circuit. Thereby, the receiver tunes so as to obtain the highest power efficiency under given conditions of transmission. A prototype receiver for wireless...
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Eigenschaften der selbstverdichtenden Betone mit zerstreuter Bewehrung.
PublicationReferat dotyczy badania wpływu różnych domieszek upłynniających i dodatków(mikrowypełniaczy oraz włókna stalowego i polipropylenowego) na właściwości mieszanki betonowej samozagęszczalnej jaki na parametry betonu stwardniałego. Badania prowadzono w dwóch etapach. W etapie I opracowano receptury kilku mieszanek samozagęszczalnych bez dodatku włókien. W etapie II na mieszankach wytypowanych w etapie I po dodaniu różnych ilości...
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Phosphate tricyclic coumarin analogs as steroid sulfatase inhibitors: synthesis and biological activity.
PublicationIn the present work, we report convenient methods for the synthesis and biological evaluation of phosphate tricyclic coumarin derivatives as potential steroid sulfatase inhibitors. The described synthesis includes the straightforward preparation of 7-hydroxy-2,3-dihydro-1H-cyclopenta[c]chromen-4-one, 3-hydroxy-7,8,9,10-tetrahydro-6H-benzo[c]chromen-6-one and 3-hydroxy-8,9,10,11-tetrahydro-7H-cyclohepta[c]chromen-6-one modified...
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Corrosion and Cavitation Resistances of Low Alloy Steel After Frictional-Mechanical Treatment
PublicationPaper presents the results of the studies of wear, corrosion and cavitation resistances of the S355J2 low alloy medium carbon steel subjected to surface modification by friction-mechanical treatment, as tested in sea water simulated solution. To evaluate the effect of the surface treatment, the comparative studies of the corrosive properties of the steel before and after treatment have been considered. The treatment due to a severe...
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Why is the cubic structure preferred in newly formed ice?
PublicationMolecular dynamics was employed to explain the preference for the cubic structure in newly formed crystals of ice. The results showed that in supercooled liquid water the molecules connected by hydrogen bonds are more likely to adopt relative orientations similar to the ones characteristic for cubic ice. The observed preference for certain relative orientations of molecules in the hydrogen-bonded pairs results in the higher probability...
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Jacek Stefański prof. dr hab. inż.
PeopleJJacek Stefański received M.Sc., Ph.D. and D.Sc. degrees in telecommunications engineering from Gdansk University of Technology (GUT), Poland, in 1993, 2000 and 2012, respectively. Awarded title of Professor by the President of Poland in 2020. Currently, he works as a professor at the Department of Radio Communication Systems and Networks (DRCSN) in GUT. From 2005 to 2009, he worked as an assistant professor in the National Institute...
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Four-body recombination in organic bulk heterojunction solar cells: an alternative interpretation
PublicationWe demonstrate a new interpretation of the previously reported quadrimolecular recombination in organic bulk heterojunction solar cells. It is suggested that the recently described (Szmytkowski 2012 Phys. Status Solidi RRL 6 300) interaction between exciton and electron–hole Langevin bound pair formed across the donor–acceptor interface is a four-particle process. This is in opposition to the treatment of this effect as a three-particle...
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Wpływ odpadowego granulatu gumowego na właściwości wulkanizatów
PublicationPrzedstawiono wyniki badań wulkanizatów napełnionych odpadowym materiałem gumowym, zawierającym nie odseparowane włókna sztuczne. Opracowano uproszczoną technologię pozyskiwania regeneratu gumowego o frakcji granulatu w wyniku mechanicznego rozdrobnienia tzw. strzępów pooponiarskich, poddanych wcześniej wymrożeniu w ciekłym azocie, oraz technologię otrzymywania mieszanki gumowej wg opracowanej receptury. Zaprezentowano porównawczą...
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Neural network breast cancer relapse time prognosis
PublicationPrzedstawiono architekturę i wyniki testowania sztucznej sieci neuronowej w prognozowaniu czasu nawrotu choroby u kobiet chorych na raka piersi. Sieć neuronowa uczona była na danych zgromadzonych przez 20 lat. Dane opisują grupę 439 pacjentów za pomocą 40 parametrów. Spośród tych parametrów wybrano 6 najistotniejszych: liczbę przerzutowych węzłów chłonnych, wielkość guza, wiek, skalę według Blooma oraz stan receptorów estrogenowych...
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Self-assembly of secondary aryl amides in cocrystals with perfluoroaryl coformers: structural analysis and synthon preferences
PublicationCooperation of aryl⋯perfluoroaryl stacking interactions and hydrogen bonds was utilized in the construction of six novel cocrystals of aromatic cis-amides with pentafluorobenzoic acid (pfba) and pentafluorophenol (pfp). They were obtained by crystallization from solution and structurally characterized. In four instances, the components form heterotetrameric motifs, in which amide:amide homodimer interacts symmetrically on two sides...
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Geometry optimization of steroid sulfatase inhibitors - the influence on the free binding energy with STS
PublicationIn the paper we review the application of two techniques (molecular mechanics and quantum mechanics) to study the influence of geometry optimization of the steroid sulfatase inhibitors on the values of descriptors coded their chemical structure and their free binding energy with the STS protein. We selected 22 STS-inhibitors and compared their structures optimized with MM+, PM7 and DFT B3LYP/6–31++G* approaches considering separately...
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Boron-doped diamond nanosheet volume-enriched screen-printed carbon electrodes: a platform for electroanalytical and impedimetric biosensor applications
PublicationThis paper focuses on the development of a novel electrode based on boron-doped diamond nanosheet full-volume-enriched screen-printed carbon electrodes (BDDPE) for use as an impedimetric biosensor. Impedimetric biosensors offer high sensitivity and selectivity for virus detection, but their use as point-of-care devices is limited by the complexity of nanomaterials’ architecture and the receptor immobilisation procedures. The study...
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Daily diet containing canned products significantly increases serum concentrations of endocrine disruptor bisphenol A in young women
PublicationNowadays, exposure to environmental factors is considered to be one of the possible causes of several lifestyle diseases, such as obesity, type 2 diabetes, cardiovascular disease, and cancer. Particularly noteworthy are endocrine‑disrupting chemicals (EDCs), which affect the metabolism of hormones and interact with their receptors, thus exerting adverse health effects. One of the most ubiquitous EDC in daily life is bisphenol A...
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1,3-Di-<i>n</i>-butylthiourea
PublicationIn the title compound, C9H20N2S, the n-butyl groups are in syn and anti positions in relation to the C=S bond. In the crystal, two molecules are connected by two N-H···S=C hydrogen bonds into a centrosymmetric dimer. Another N-H···S=C hydrogen bond links the dimers, forming layers with a hydrophilic interior and a hydrophobic exterior, which spread across the (100) plane. Interlacing of the...
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Increased resonance energy transfer between fluorophores bound to DNA in proximity to metallic silver particles.
PublicationZbadano wpływ nanocząstek metalicznego srebra na rezonansowe przekazywanie energii między fluoroforami związanymi z DNA. Donor (pochodna kumaryny) i akceptor (Cy3) umieszczono na przeciwległych końcach DNA o strukturze podwójnej helisy i o 23 parach bazowych. W nieobecności cząstek srebra wydajność przekazywania energii w tym układzie wynosiła ok. 9%, zaś po umieszczeniu go między kwarcowymi płytkami pokrytymi filmem wysepek...
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Water uptake and energetics of the formation of barium zirconate based multicomponent oxides
PublicationA group of multi-component oxides based on BaZrO3 have been prepared using a solid-state reaction method and examined in terms of their water uptake and thermodynamics of formation. Depending on the type and amount of acceptor substitution, the synthesized compounds exhibit various proton defect concentrations, reaching up to 0.2 mol/mol for a compound containing 10 different elements in the B-sublattice, where 50% of them are...
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2023 Chemia Bioorganiczna i Biostereochemia
e-Learning CoursesGłównym celem chemii bioorganicznej jest wykorzystanie zdobyczy chemii organicznej w celu tworzenia nowych biomolekuł lub modyfikacji już istniejących. Z drugiej strony biostereochemia obejmuje swoim zakresem - pojęcia stereochemiczne takie jak: stereoizomery, konfiguracja absolutna i względna, sposób przedstawiania stereoizomerów; poznanie przestrzennych uwarunkowań procesów biochemicznych i chemicznych; oddziaływania z obiektami...
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Application of H2O2 to optimize ammonium removal from domestic wastewater
PublicationThe paper presents the results of application of hydrogen peroxide (H2O2) for the optimization of the effects of ammonia nitrogen removal from domestic wastewater. The investigations were carried out at a model wastewater treatment plant consisting of a preliminary sedimentation tank and a sand filter with a horizontal flow of wastewater at a constant hydraulic load of 1.44 L/day. The efficiency of ammonia nitrogen removal was...
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ENVIRONMENTAL DEGRADATION OF DISSIMILAR AUSTENITIC 316L AND DUPLEX 2205 STAINLESS STEELS WELDED JOINTS
PublicationThe paper describes structure and properties of dissimilar stainless steels welded joints between duplex 2205 and austenitic 316L steels. Investigations were focused on environmentally assisted cracking of welded joints. The susceptibility to stress corrosion cracking (SCC) and hydrogen embrittlement was determined in slow strain rate tests (SSRT) with the strain rate of 2.2 × 10–6 s–1. Chloride-inducted SCC was determined in the...
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Paweł Śliwiński dr hab. inż.
PeopleDiplomas and academic degrees. Training 2017: degree of habilitated doctor;2006: PhD in Technical Sciences. PhD thesis defended with distinction. Gdansk University of Technology, Faculty of Mechanical Engineering.2000: Master of Science. Graduated from the university with distinction. Gdansk University of Technology, Faculty of Mechanical Engineering.1995: Mechanical technician. Graduated from a Technical Secondary School...
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Wzmacnianie podtorza kolejowego metodą stabilizacji ubocznymi produktami spalania
PublicationUboczne produkty spalania powstają na skutek spalania w piecach bezresztowych różnych rodzajów węgla. Popioły odprowadzane spod elektrofiltrów w postaci suchego pyłu posiadają właściwości wiążące i mogą być stosowane jako samodzielne spoiwo lub jako dodatek do innych spoiw. Każdorazowo przed przystąpieniem do stabilizacji gruntu spoiwem hydraulicznym należy sporządzić receptę laboratoryjną. Najważniejszym parametrem dla wykonanego...
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Wzmacnianie podtorza kolejowego metodą stabilizacji ubocznymi produktami spalania
PublicationUboczne produkty spalania powstają na skutek spalania w piecach bezresztowych różnych rodzajów węgla. Popioły odprowadzane spod elektrofiltrów w postaci suchego pyłu posiadają właściwości wiążące i mogą być stosowane jako samodzielne spoiwo lub jako dodatek do innych spoiw. Każdorazowo przed przystąpieniem do stabilizacji gruntu spoiwem hydraulicznym należy sporządzić receptę laboratoryjną. Najważniejszym parametrem dla wykonanego...
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Configurational and Conformational Preferences in Stereoselective Acylations of N-Methyl-1,3-diaminopropane with Acyl Chlorides
PublicationEvidence for a stereoinduction profile of the reaction of N-methyl-1,3-diaminopropane with acyl chlorides was provided. A possibility to engage in intramol. CH2···HN and Cl···H-N interactions and the proton migration process to the methylamino group leads to the E secondary amides carrying the N···H+···N or N-H···N bridges, that show unusual spectroscopic images. Empirical relations between the ΔδC chem. shift differences,...
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Wet H2S corrosion and degradation of pipeline in amine regeneration system
PublicationThe paper presents the results of NDT examinations, metallographic tests and risk assessment of degradation related to corrosion of amine regeneration unit in a desulphurisation system. Intensive corrosion resulting from acid gases environment upon water condensation causes perforation of the pipeline. Detailed analysis reveals cracking related to the mechanism of wet H2S. Hydrogen penetration, resulting from the wet H2S process,...
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Wodór jako paliwo cz. 1
PublicationW artykule przedstawiono wodór jako nowoczesny nośnik energii oraz jego zastosowanie techniczne w ujęciu konwersji energii. Przybliżono jego odkrycie, właściwości oraz jego wykorzystanie od odkrycia do współczesności. Dokonano opisu budowy i zasady działania ogniw paliwowych. Omówiono ich podział przedstawiając zalety i wady każdego rozwiązania oraz ich zastosowanie techniczne w zależności od typu ogniwa.
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Path Loss Analysis for the IoT Applications in the Urban and Indoor Environments
PublicationThe Internet of Things (IoT) networks concept implies their presence in a various and untypical locations, usually with a disturbed radio signals propagation. In the presented paper an investigation of an additional path loss observed in an underground environment was described. The proposed measurement locations correspond to the operation areas of rapidly growing narrowband IoT (NBIoT) networks, the ones using the Long Term Evolution...
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Position Estimation in Corridors Along the Coupled Mode of Radiating Cables
PublicationRadiating cables are mostly used to provide radio communication in tunnels or corridors, but they can also be used to estimate the position of a mobile terminal along the cable. In this paper, a measuring receiver’s position was estimated by measuring the difference in the direct signal’s reception time, which was generated by a transmitter connected to one end of the radiating cable, and the delayed signal retransmitted from another...
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„Jeśli my zapomnimy, kto będzie pamiętał?". Dzieło sztuki jako manifestacja postpamięci
PublicationTekst jest próbą ujęcia relacji między postpamięcią (lub inaczej ujmując - „pamięcią zastępczą”) a sztuką, przy czym szczególny akcent położono na sztuki wizualne. Dokonano analizy dzieł artystów młodszego pokolenia, podejmujących temat pamięci o Szoa (między innymi Libera, Bałka, Żmijewski, do pewnego stopnia Betlejewski), traktując je jako formy manifestacji postpamięci. Wychodząc z założenia, że analiza zjawisk artystycznych...
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Anion–water interactions of weakly hydrated anions: molecular dynamics simulations of aqueous NaBF4 and NaPF6
PublicationIn aqueous ionic solutions, both the structure and the dynamics of water are altered dramatically with respect to the pure solvent. The emergence of novel experimental techniques makes these changes accessible to detailed investigations. At the same time, computational studies deliver unique possibilities for the interpretation of the experimental data at the molecular level. Here, using molecular dynamics simulations, we demonstrate...
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Nanostructure of the laser-modified transition metal nanocomposites for water splitting
PublicationAlthough hydrogen is considered by many to be the green fuel of the future, nowadays it is primarily produced through steam reforming, which is a process far from ecological. Therefore, emphasis is being put on the development of electrodes capable of the efficient production of hydrogen and oxygen from water. To make the green alternative possible, the solution should be cost-efficient and well processable, generating less waste...
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Effect of water salinity on properties of multipass underwater wet manual metal arc welded joints
PublicationThe weldability of steel under the water is limited due to the influence of the environment. Water causes limited visibility, presence of the residual stresses, increasing the cooling rate, and increasing the diffusible hydrogen content in deposited metal, leading to the formation of brittle microstructures in heat-affected zone (HAZ). The paper presents the results of mechanical properties testing of S420G2+M steel welded joints...
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Bis(diisopropylammonium) thiosulfate and bis(tert-butylammonium) thiosulfate
PublicationTwo new dialkylammonium thiosulfates, namely bis(diisopropylammonium) thiosulfate, 2C6H16N+S2O3 2-, (I), and bis(tert-butylammonium) thiosulfate, 2C4H12N+S2O3 2-, (II), have been characterized. The secondary ammonium salt (I) crystallizes with Z = 4, while the primary ammonium salt (II), with more...
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Performance and emission characteristics of diesel engines running on gaseous fuels in dual-fuel mode
PublicationConventional fossil fuels are being substituted with alternative green fuels because of their greenhouse gas emissions and pollution problems, which pose a severe threat to the environment. Several studies have reported the usage of biodiesel and gaseous fuels in both single and dual-fuel modes. Gaseous fuels such as producer gas, biogas, syngas, and hydrogen produced from renewable biomass could potentially be used along with...
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Leszek Ziemczonek dr
PeopleUniversity education 1973-1978 – Nicolaus Copernicus University in Toruń, University of Gdańsk in Gdańsk, Mathematical Physics, M. Sc. 1979 – Diploma of Postgraduate Studies, Pedagogics 1989 – Institute of Physics, Polish Academy of Sciences in Warsaw, Theoretical Physics, Ph. D. 2010-2012 – Diploma of Postgraduate Studies, Mathematics Training: · 09.1983 – Trieste (Italy) – International Centre for Theoretical Physics...
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X-Ray photoemission spectroscopy measurements of the Nb-V-Sr-O ceramics
Open Research DataNiobium doped strontium vanadate based perovskite SrV1-xNbxO3-δ materials were prepared via conventional solid state reaction (SSR) method. For comparison, different samples with a various amount of niobium dopant in the structure were synthesized; x = 0; 0,2; 0,5; 0,8 and 1. Samples were sintered by two-steps: first under a pure hydrogen (purity >99.999%)...
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Antitumor triazoloacridinone C-1305 as a potent FLT3 tyrosine kinase inhibitor in human acute myeloid leukemia (AML) cells.
PublicationJednym z defektów molekularnych u pacjentów z ostrą białaczką szpikową (AML) jest konstytutywna aktywacja receptoroweej kinazy tyrozynowj FLT3.Najczęstszą mutacją genu kodującego FLT3 jest wewnętrzna tandemowa duplikacja ITD we fragmencie okołobłonowym receptora. W pracy zbadano, czy przeciwnowotworowy triazoloakrydon C-1305 może być inhibitorem kinazy tyrozynowej FLT3. Badania przeprowadzono na dwóch liniach komórkowych białaczek...
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Ceria Based Protective Coatings for Steel Interconnects Prepared by Spray Pyrolysis
PublicationStainless steels can be used in solid oxide fuel/electrolysis stacks as interconnects. For successful long term operation they require protective coatings, that lower the corrosion rate and block chemical reactions between the interconnect and adjacent layers of the oxygen or the hydrogen electrode. One of the promising coating materials for the hydrogen side is ceria. Using standard sintering techniques, ceria sinters at around...
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Degradation of Rhodamine dyes by Advanced Oxidation Processes (AOPs) – Focus on cavitation and photocatalysis - A critical review
PublicationThis review evaluates selected advanced oxidation processes (AOPs) - cavitation and photocatalysis - successfully used for wastewater treatment towards degradation of Rhodamine (Rh) dyes. Reactor configuration and impact of process parameters and oxidants addition (hydrogen peroxide, ozone, persulfates) on degradation effectiveness along with degradation mechanisms are discussed. Best technologies provide 100% degradation within...
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Structural properties of hydration shell around various conformations of simple polypeptides
PublicationIn this paper we investigate structural properties of water within the solvation shell around the peptide core created by a well-defined conformation of polypeptide chain. The following secondary structures are investigated: linear (straight chain), and three helices PII (polyproline-like), 310, and α. We propose using the two-particle contribution to entropy as a rational measure of the water structural ordering within the solvation...
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Krzysztof Piotr Bielawski Prof. dr hab.
People -
Fizyczne podstawy mikrokontrolerowych układów pomiarowych (2022/2023)
e-Learning CoursesKurs skierowany dla studentów VI semestru, kierunek Fizyka Techniczna, specjalność Informatyka Stosowana (ale nie tylko). Kurs obejmuje naukę podstawowych metod projektowania i programowania prostych systemów wbudowanych (ang. embedded systems), czyli specjalizowanych systemów informatycznych, odpowiadających za wykonywanie ściśle określonych zadań - głównie związanych z monitorowaniem i sterowaniem. W ramach kursu przedstawiane...