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Wyniki wyszukiwania dla: METABOLITE PURIFICATION
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Rhamnolipid CMC Prediction
PublikacjaRelationships between the purity, pH, hydrophobicity (log Kow) of the carbon substrate, and the critical micelle concentration (CMC) of rhamnolipid type biosurfactants (RL) were investigated using a quantitative structure–property relationship (QSPR) approach and are presented here for the first time. Measured and literature CMC values of 97 RLs, representing biosurfactants at different stages of purification, were considered....
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Synthetic strategies in construction of organic macromolecular carrier–drug conjugates
PublikacjaMany metabolic inhibitors, considered potential antimicrobial or anticancer drug candidates, exhibit verylimited ability to cross the biological membranes of target cells. The restricted cellular penetration ofthose molecules is often due to their highhydrophilicity. One of the possible solutions to this problem is aconjugation of an inhibitor with a molecular organic nanocarrier. The conjugate thus formed should beable to penetrate...
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Spektrometria mas jako narzędzie umożliwiające poznanie metabolomu-główne strategie i wyzwania
PublikacjaBadania z zakresu metabolomiki ukierunkowane są na wykrywanie i oznaczanie endogennych związków małocząsteczkowych o masie <1000 Da (np. aminokwasy, cukry, lipidy) w próbkach biologicznych takich jak płyny biologiczne (głównie krew i mocz) oraz kondensaty wydychanego powietrza. Ze względu na szerokie spektrum występowania i niskie poziomy stężeń metabolitów w próbkach, analizy metabolomiczne wymagają stosowania technik o wysokiej...
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Versatility of putative aromatic aminotransferases from Candida albicans.
PublikacjaAmino acids constitute the key sources of nitrogen for growth of Candida albicans. In order to survive inside the host in different and rapidly changing environments, this fungus must be able to adapt via its expression of genes for amino acid metabolism. We analysed the ARO8, ARO9, YER152C, and BNA3 genes with regards to their role in the nutritional flexibility of C. albicans. CaAro8p is undoubtedly the most versatile enzyme...
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Mechanism-based inactivation of human cytochrome P450 1A2 and 3A4 isoenzymes by antitumor triazoloacridinone C-1305.
Publikacja5-Dimethylaminopropylamino-8-hydroxytriazoloacridinone, C-1305, is a promising antitumor therapeutic agent with high activity against several experimental tumors. It was determined to be a potent and selective inhibitor of liver microsomal and human recombinant cytochrome P450 (CYP) 1A2 and 3A4 isoenzymes. Therefore, C-1305 might modulate the effectiveness of other drugs used in multidrug therapy. The objective of this study was...
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The influence of cultivation conditions on the myrosinase activity and glucosinolate content in white cabbage
PublikacjaIn the process of biofumigation typically natural compounds present in Brassicaceae family are used to combat pests and protect crops. Glucosinolates, sulfur-containing secondary metabolites found in Brassica plants, are hydrolized by the enzyme myrosinase (β-thioglucosidase, EC 3.2.3.1) with the liberation of degradation products such as isothiocyanates, nitriles, thiocyanates and epithionitriles. Isothiocyanates are the most...
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Probiotic potential of Bacillus Isolates from Polish Bee Pollen and Bee Bread
PublikacjaThe main goal of this study was the evaluation of the probiotic potential of 10 Bacillus spp. strains isolated from 5 bee bread and 3 bee pollen samples. The antagonistic interaction with Staphylococcus aureus and Escherichia coli was a primary criterion for the preliminary selection of the isolates. Three out of ten strains—PY2.3 (isolated from pollen), BP20.15 and BB10.1 (both isolated from bee bread)—were found to be possible...
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Paenibacillus alvei MP1 as a Producer of the Proteinaceous Compound with Activity against Important Human Pathogens, Including Staphylococcus aureus and Listeria monocytogenes
PublikacjaAn emerging need for new classes of antibiotics is, on the one hand, evident as antimicrobial resistance continues to rise. On the other hand, the awareness of the pros and cons of chemically synthesized compounds’ extensive use leads to a search for new metabolites in already known reservoirs. Previous research showed that Paenibacillus strain (P. alvei MP1) recovered from a buckwheat honey sample presented a wide spectrum of...
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Self-Testing of Analog Parts Terminated by ADCs Based on Multiple Sampling of Time Responses
PublikacjaA new approach for self-testing of analog parts terminated by analog-to-digital converters in mixed-signal electronic microsystems controlled by microcontrollers is presented. It is based upon a new fault diagnosis method using a transformation of the set of voltage samples of the time response of a tested analog part to a square impulse into localization curves placed in a multidimensional measurement space. The method can be used...
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Parametric analysis of Istanbul's Ring Road viaduct for three levels of seismic load
PublikacjaThe paper presents a parametric analysis of the Istanbul's ring road viaduct that is currently under construction within the Northern Marmara Highway project. The structure, due to its location on seismic prone areas is exposed to seismic loads of different strengths and different return periods. The study is focused on concrete bridge supports that are design to work in nonlinear range. The parametric study, conducted in MATLAB...
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Observation Value Analysis – Integral Part of Bayesian Diagnostics
PublikacjaThe decision making process, in general, is understood as a process of selecting one of the available solutions to the problem. One of possible approaches supporting the process is Bayesian statistical decision theory providing a mathematical model to make decisions of a technical nature in conditions of uncertainty. Regarding above, a detailed subject of the research is to analyze the value of the observation, which is a part...
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Framework for RIDM within functional safety management process
PublikacjaThe functional safety management in life cycle is a complex process starting with identifying hazards and defining safety-related functions (SRFs) with risk assessment oriented at determining the safety integrity level. Another element of such life cycle is a verification of required SIL for designed safety-related system which implements safety function. Due to complexity of the problem, to overcome difficulties in safety-related...
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Foundations of Grid Processing Architecture for the Comcute System
PublikacjaFundamental system algorithms and structures implemented in the Comcute system are described and analysed in detail. Layered architecture of the system model is highlighted. System tasks of the layers are elaborated, presented and described. Operational details of communication interfaces among layers are worked out and examined. The focus is put onto implemented system components with regard to their operability and efficiency....
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Time-current tripping characteristics of RCDs for sinusoidal testing current
PublikacjaLow-voltage electrical installations are verified initially – before being put into operation, as well as periodically – during their utilization. According to the IEC standards, the scope of the verification includes measurements of both the tripping current and the disconnection time of residual current devices (RCDs). Experiences in RCDs testing show that disconnection times of two or more similar RCDs can be quite different....
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Numerical Test for Stability Evaluation of Discrete-Time Systems
PublikacjaIn this paper, a new numerical test for stability evaluation of discrete-time systems is presented. It is based on modern root-finding techniques at the complex plane employing the Delaunay triangulation and Cauchy's Argument Principle. The method evaluates if a system is stable and returns possible values and multiplicities of unstable zeros of the characteristic equation. For state-space discrete-time models, the developed test...
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Experimental Investigations On The Momentum Pressure Drop During Flow Boiling Of R134a
PublikacjaThe article presents experimental investigations of the pressure drop during twophase flow. Experiments were performed for both adiabatic and heated flow of R134a. Obtained flow patterns were compared with the literature. Obtained data is used to validate momentum pressure drop predictions, a set of graphs showing comparisons, for a representative set of experimental conditions, of the two-phase frictional pressure gradients for...
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Analysis of measurement uncertainty for contact-less method used to measure the position of catenary contact wire, performed with the use of Monte Carlo method
PublikacjaCurrently the majority of main railway lines in Europe are electrified, and electric trains have the biggest share in the entire amount of rail transport. Reliability of electrified railways is closely related to the issue of supplying traction vehicles with energy. The problems connected with diagnostics of energy consumption node, namely the contact line and the current collector, are therefore of fundamental importance for maintaining...
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Ring thruster - a preliminary optimisation study
PublikacjaThe ring thruster is a new type of propeller, for which there is no experimental data to verify analytical design calculations. A significant feature of the ring thruster is the absence of a shaft. Propeller blades are mounted to the ring rotating inside the housing, which has the shape of a nozzle. For this reason the ring thruster is closest, with respect to both the construction and principle of operation, to the Kort nozzle...
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Impact of obesity on cardiovascular health
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Absorptive Desulfurization of Model Biogas Stream Using Choline Chloride-Based Deep Eutectic Solvents
PublikacjaThe paper presents a synthesis of deep eutectic solvents (DESs) based on choline chloride (ChCl) as hydrogen bond acceptor and phenol (Ph), glycol ethylene (EG), and levulinic acid (Lev) as hydrogen bond donors in 1:2 molar ratio. DESs were successfully used as absorption solvents for removal of dimethyl disulfide (DMDS) from model biogas steam. Several parameters affecting the absorption capacity and absorption rate have been...
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Evolving gene regulatory networks controlling foraging strategies of prey and predators in an artificial ecosystem
PublikacjaCo-evolution of predators and prey is an example of an evolutionary arms race, leading in nature to selective pressures in positive feedback. We introduce here an artificial life ecosystem in which such positive feedback can emerge. This ecosystem consists of a 2-dimensional liquid environment and animats controlled by evolving artificial gene regulatory networks encoded in linear genomes. The genes in the genome encode chemical...
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Cyanogenic Compounds and Estrogen Disruptors
PublikacjaBalanced diet consists largely of plants containing cyanogenic compounds in the form of the more common cyanogenic glycosides and sometimes lipids. Maize, wheat, rye, apples, barley, oats, sugar cane and yet many other plants consumed by humans contain cyanogenic compounds. However the risk of poisoning is negligible as it is very easy to remove the toxic HCN by grinding and drying in air or soaking in water and an additional...
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Knowledge-based functional safety management using ProSIL software
PublikacjaIn the article the ProSIL software for computer aided functional safety management is presented. The software consists of three modules for the determination of the required SIL level (ProSILen) and verification of the SIL level (ProSILver). In the ProSIL the calibrated knowledge-based risk graph method for determining the required safety integrity level (SIL) of the safety functions identified in hazard analysis is implemented....
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GROUP COMPOSER - System for Modeling Agents’ Team Building for Tasks
PublikacjaMulti-agent systems consist of many autonomous units, called agents, that can interact when trying to achieve their goals. The selection of interaction partners is called team formation. Three basic approaches can be considered to match multi-agent system resources to the problem at hand. To research the properties of different approaches, a software for modeling team formation in multi-agent systems has been created and is presented...
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Hybrid Fuzzy-Ontological Project Framework of a Team Work Simulation System
PublikacjaThe aim of this article is to present the project framework for constructing a Software Process Simulation Modeling (SPSM) system. SPSM systems can be used as a virtual environment for the selection of methods and tools of project management in IT support organizations. The constructed system simulates the Scrum methodology, including the management processes and the project roles. For the implementation of Scrum processes, the...
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INTERLABORATORY COMPARISON OF THE ELECTROMAGNETIC EMISSION MEASUREMENTS USING FAR AND GTEM TEST SITES UP TO 1 GHz
PublikacjaElectromagnetic emission limiting is one of the basic requirements in the European Directive 2014/30/EU (EMC Directive). Manufacturers often use alternative methods of measurements to make preliminary verification of emission. This paper presents and analyzes problem with comparison between measurements in different test sites: FAR (Fully Anechoic Room) and GTEM (Gigahertz Transverse Electromagnetic cell). FAR is assumed as the...
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The concept of research on ecological, energy and reliability effects of modified marine fuel oils application to supply compression-ignition engines in real conditions
PublikacjaWithin the article, basic assumptions of the research project financed by Regional Fund for Environmental Protection and Water in Gdansk were described. The project concerns the experimental investigations carried out on laboratory compression-ignition engine in conditions of its supply with a non-standard marine fuel oil. Configuration and measuring capability of laboratory test bed presently being constructed were introduced....
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Design and experimental validation of a single-stage PV string inverter with optimal number of interleaved buck-boost cells.
PublikacjaIncreasing converter power density is a problem of topical interest. This paper discusses an interleaved approach of the efficiency increase in the buck-boost stage of an inverter with unfolding circuit in terms of losses in semiconductors, output voltage ripples and power density. Main trends in the power converter development are reviewed. A losses model was designed and used for the proposed solution to find an optimal number...
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Texture Features for the Detection of Playback Attacks: Towards a Robust Solution
PublikacjaThis paper describes the new version of a method that is capable of protecting automatic speaker verification (ASV) systems from playback attacks. The presented approach uses computer vision techniques, such as the texture feature extraction based on Local Ternary Patterns (LTP), to identify spoofed recordings. Our goal is to make the algorithm independent from the contents of the training set as much as possible; we look for the...
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Biosynthetic and synthetic access to amino sugars.
PublikacjaAmino sugars are important constituents of a number of biomacromolecules and products of mi crobial secondary metabolism, including antibiotics. For most of them, the amino group is located at the positions C1, C2 or C3 of the hexose or pentose ring. In biological systems, amino sugars are formed due to the catalytic activity of specific aminotransferases or amidotransferases by introducing an amino functionality derived from L-glutamate...
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Drożdżowe systemy ekspresyjne jako narzędzie nowoczesnej mikrobiologii przemysłowej
PublikacjaDrożdże łączą zalety prokariotycznych i eukariotycznych systemów ekspresyjnych. Charakteryzuje je szybki wzrost, osiągają też znacznie większą biomasę w porównaniu z bakteriami. W odróżnieniu od bakterii, drożdże zdolne są do przeprowadzania modyfikacji posttranslacyjnych białek. Kolejną zaletą drożdżowych systemów ekspresyjnych jest zdolność komórek drożdżowych do sekrecji białek do pożywki hodowlanej. W laboratoriach naukowych...
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Charakterystyka polifenoli: występowanie, właściwości, przegląd metodyk analitycznych
PublikacjaPolifenole należą do grupy wtórnych metabolitów roślin. Główne źródła w żywności, dzienne spożycie i biodostępność polifenoli zależą od gatunku rośliny, klimatu, sezonu, procesu obróbki i przyzwyczajeń kulturowych. Związki polifenolowe wykazują szereg korzystnych dla zdrowia właściwości, pośród których wymienia się głównie aktywność przeciwutleniającą, przeciwrakotwórczą i przeciwzapalną. Potencjalnie szerokie zastosowania tych...
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Removal of cyclohexane and ethanol from air in biotrickling filters inoculated with Candida albicans and Candida subhashii
PublikacjaThis paper presents investigations on the removal of cyclohexane and ethanol from air in polyurethane- -packed biotrickling filters, inoculated with Candida albicans and Candida subhashii fungal species. Results on process performance together with flow cytometry analyses of the biofilm formed over packing elements are presented and discussed. The results indicate that the presence of ethanol enhances the removal efficiency of cyclohexane...
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Myrosinase activity in different plant samples; optimisation of measurement conditions for spectrophotometric and pH-stat methods
PublikacjaMyrosinase found in Brassicaceae plants, is the enzyme responsible for hydrolysis of glucosinolates. As a result a variety of biologically active metabolites are liberated, whose importance in crop protection and especially in cancer chemoprevention is rapidly gaining recognition. The growing practical application of glucosinolate degradation products requires that sensitive and reliable methods of myrosinase activity determination...
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UDP-glukuronylotransferazy - białka siateczki śródplazmatycznej. Struktura i mechanizm działania
PublikacjaIzoenzymy UDP-glukuronylotransferazy (EC. 2.4.1.17), UGT, katalizują w organizmach ssaków reakcję koniugacji grupy glikozylowej pochodzącej z nukleotydu UDPGA z aglikonem. UDPGA jest przyłączany do odpowiedniej grupy funkcyjnej metabolitu I fazy, rzadziej związku wyjściowego, przez co polarność aglikonu i zdolność jego wydalania z komórki zwiększa się, a to w konsekwencji obniża efekt toksyczny.Struktura UGT zawiera 2 domeny. Domena...
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Carbon nanowalls: A new versatile graphene based interface for laser desorption/ionization-mass spectrometry detection of small compounds in real samples.
PublikacjaCarbon nanowalls, vertically aligned graphene nanosheets, attract attention owing to their tunable band-gap, high conductivity, high mechanical robustness, high optical absorbance and other remarkable properties. In this paper, we report for the first time, the use of hydrophobic boron-doped carbon nanowalls (CNWs) for laser desorption/ionization of small compounds and their subsequent detection by mass spectrometry (LDI-MS). The...
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The treatment of wastewater containing pharmaceuticals in microcosm constructed wetlands: the occurrence of integrons (int1–2) and associated resistance genes (sul1–3, qacEΔ1)
PublikacjaThe aim of this study was to analyze the occurrence of sulfonamide resistance genes (sul1–3) and other genetic elements as antiseptic resistance gene (qacEΔ1) and class 1 and class 2 integrons (int1–2) in the upper layer of substrate and in the effluent of microcosm constructed wetlands (CWs) treating artificial wastewater containing diclofenac and sulfamethoxazole (SMX), which is a sulfonamide antibiotic. The bacteria in the substrate...
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Postbiotics in oncology: science or science fiction?
PublikacjaThe gut microbiome has been increasingly understood to play a critical role in carcinogenesis and cancer disease progression. The most recent research advancements have shown that different tools of microbiota manipulation contribute to gut microbiome–immune–oncology axis modulation, offering exciting opportunities for targeted interventions aimed at improving the efficacy of established anti-cancer therapy. Postbiotics are a new...
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Comparative Analysis of Phytochemical Profiles and Selected Biological Activities of Various Morphological Parts of Ligustrum vulgare
PublikacjaLigustrum vulgare (LV), widely cultivated in Europe and often used in hedges, has been histori-cally recognized in folk medicine for its potential health benefits. This study focused on exploring the untargeted identification of secondary metabolites in ethanol extracts (70% v/v) from differ-ent morphological parts (young shoots, leaves, flowers and fruits) of LV at various stages of plant development, using ultra-high-performance...
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Elicitation strategies for the improvement of essential oil content in Rhododendron tomentosum (Ledum palustre) bioreactor-grown microshoots
PublikacjaRhododendron tomentosum Harmaja, previously Ledum palustre L., is a fragrant plant growing in swampy areas, which is characterized by well-known repellent properties and the anti-arthritic potential. In the present study, R. tomentosum microshoots cultivated in RITA® bioreactor, providing the alternative, environment-independent source of the valuable essential oil, were treated for 7 days with copper and nickel salts, methyl jasmonate,...
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Substancje groźne, niebezpieczne i pożyteczne.Tom 1: Pierwiastki i związki nieorganiczne
PublikacjaLudzie od początku swojego istnienia byli narażeni na działanie szkodliwych substancji chemicznych. Pierwotnie były to groźne dla życia opary wulkaniczne, toksyczne minerały – takie, jak arszenik, rudy ołowiu czy rtęci, szkodliwe metabolity wtórne (toksyny) wytwarzane przez mikroorganizmy, rośliny i zwierzęta, a także produkty spalania substancji organicznych, w tym dymy z palących się lasów czy stepów, zawierające czad, dioksyny,...
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Prophylaxis of Non-communicable Diseases: Why Fruits and Vegetables may be Better Chemopreventive Agents than Dietary Supplements Based on Isolated Phytochemicals?
PublikacjaThe World Health Organization (WHO) report from 2014 documented that non-communicable socalled civilization diseases such as cardiovascular disease, chronic respiratory diseases, cancer or type 2 diabetes are responsible for over 50% of all premature deaths in the world. Research carried out over the past 20 years has provided data suggesting that diet is an essential factor influencing the risk of development of these diseases....
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Identification of novel psychoactive substances 25B-NBOMe and 4-CMC in biological material using HPLC-Q-TOF-MS and their quantification in blood using UPLC–MS/MS in case of severe intoxications
PublikacjaThis paper describes cases of poisoning caused by new psychoactive substances such as: 25BNBOMe (2-(4-bromo-2,5-dimethoxyphenyl)-N-[(2-methoxyphenyl)methyl]ethanamine) and 4-CMC (1-(4-chlorophenyl)-2-(methylamino)-1-propanone). The analytical procedure includes rapid and selective method for the extraction and determination of 4-CMC and 25B-NBOMe in blood samples using UPLC–MS/MS technique. To the best of our knowledge,this is...
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Association of Higher Rates of Type 2 Diabetes (T2DM) Complications with Psychological and Demographic Variables: Results of a Cross-Sectional Study
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PAID-PL—The Polish Version of the Problem Areas in Diabetes Scale: Perfect Reliability and a One-Factor Structure
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Relations of Well-Being, Coping Styles, Perception of Self-Influence on the Diabetes Course and Sociodemographic Characteristics with HbA1c and BMI Among People with Advanced Type 2 Diabetes Mellitus
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Large deformation finite element analysis of undrained pile installation
PublikacjaIn this paper, a numerical undrained analysis of pile jacking into the subsoil using Abaqus software suit has been presented. Two different approaches, including traditional Finite Element Method (FEM) and Arbitrary Lagrangian–Eulerian (ALE) formulation, were tested. In the first method, the soil was modelled as a two-phase medium and effective stress analysis was performed. In the second one (ALE), a single-phase medium was assumed...
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Preliminary experimental research on stability of truss' joint with positive eccentricity
PublikacjaRecently, a very large interest in lightweight steel structures made from cold-formed sections has been noticeable. In the design practice, a large emphasis is put on rational shaping of both the thin-walled elements and constructions designed on them. The aim of this paper is to present the methodology for preparation of experimental research that model the behaviour of members in trusses made of cold-formed sections with positive...
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Mobile indicators in GIS and GPS positioning accuracy in cities
PublikacjaThe publication describes the possible use of tele-geoprocessing as a synergy of modern IT solutions, telecommunications and GIS algorithms. The paper presents a possibility of urban traffic monitoring with the use of mobile GIS indicators of dedicated monitoring system designed for taxi corporation. The system is based on a stationary and mobile software package. The optimal and minimal assumptions for the monitoring of urban...
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Ontology management in the multi-agent system for the it evaluation
PublikacjaThe team of researchers at the Gdańsk University of Technology is currently developing a model of the multi-agent system (MAS_IT) that would aid the IT managers to find the most appropriate technology to the goals assumed. The knowledge is to be provided by experts and stored in the facts and rules bases. The responsibility of the verification process-on the input and query stages-is given to the ontology, making it to some extend...