Search results for: knowledge base
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Structure-based design and evaluation of novel N-phenyl-1H-indol-2-amine derivatives for fat mass and obesity-associated (FTO) protein inhibition
PublicationFat mass and obesity-associated (FTO) protein contributes to non-syndromic human obesity which refers to excessive fat accumulation in human body and results in health risk. FTO protein has become a promising target for anti-obesity medicines as there is an immense need for the rational design of potent inhibitors to treat obesity. In our study, a new scaffold N-phenyl-1H-indol-2-amine was selected as a base for FTO protein inhibitors...
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Mechanical and Microstructural Characterization of TIG Welded Dissimilar Joints between 304L Austenitic Stainless Steel and Incoloy 800HT Nickel Alloy
PublicationIn this article, the mechanical properties and microstructure of 304L austenitic stainless steel/Incoloy 800HT nickel alloy dissimilar welded joints are investigated. The joints were made of 21.3 mm × 7.47 mm tubes using the TIG process with the use of S Ni 6082 nickel filler metal. No welding imperfections were found and high strength properties of joints were obtained, meeting the assumed acceptance criteria of the product’s...
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Review of methods for assessing traffic conditions on basic motorway and expressway sections
PublicationMotorways and expressways are the core of each country’s road system. Road planning, design and management requires tools to ensure that roads have the right geometry, traffic layout and equipment. These include methods for capacity estimation and assessing traffic conditions. Because the paper focusses on the basic segments of motorways and expressways (sections located between interchanges and outside of their influence), its...
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FEM modelling of screw displacement pile interaction with subsoil
PublicationPredicting the-settlement characteristics of piles is an important element in the designing of pile foundations. The most reliable method in evaluating pile-soil interaction is the static load test, preferably performed with instrumentation for measuring shaft and pile base resistances. This, however, is a mostly post-implementation test. In the design phase, prediction methods are needed, in which numerical simulations play an...
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Dielectric Properties of BiNbO<sub>4</sub>-Based Ceramic-Polymer Composites with 0-3 Connectivity
PublicationIn the present study two-phase BiNbO4//PVDF composites with 0-3 connectivity were studied by impedance spectroscopy within the frequency range Δν=100Hz-1MHz at room temperature. Polyvinylidene fluoride (PVDF) acted as a matrix whereas bismuth niobate (BiNbO4) powder acted as a dispersed phase. The volume fraction of the ceramic phase was cV=2, 4, 6, 8, 10, 16 and 20vol%. Analysis of the impedance data registered for composites...
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Behaviour of asymmetric structures with base isolation made of Polymeric Bearings
PublicationEarthquake-induced ground motions are the most severe and unpredictable threats to the structures all around the world. Seismic excitations cause a lot of damage in a wide variety of ways, leaving thousands of casualties in their wake. During the last few years alone, the world has witnessed many major earthquakes, five of which have caused far-reaching consequences of a national scale for Haiti (January 2010), Chile (February...
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Imidazoacridinone-dependent lysosomal photodestruction: a pharmacological Trojan horse approach to eradicate multidrug-resistant cancers
PublicationMultidrug resistance (MDR) remains a primary hindrance to curative cancer therapy. Thus, introduction of novel strategies to overcome MDR is of paramount therapeutic significance. Sequestration of chemotherapeutics in lysosomes is an established mechanism of drug resistance. Here, we show that MDR cells display a marked increase in lysosome number. We further demonstrate that imidazoacridinones (IAs), which are cytotoxic fluorochromes,...
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Behaviour of deformed steel columns exposed to impact load during earthquakes: numerical analysis
PublicationIt has been observed during earthquakes that the so called soft-storey failure of an upper floor of a building leads to considerable vertical impact load acting on structural members of the lower storeys. The aim of this paper is to investigate numerically the behaviour of horizontally deformed columns (deformation as the result of earthquake loading) that are additionally subjected to vertical impact load. In the first stage of...
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Intercalation complex of imidazoacridinone C-1311, a potential anticancer drug, with DNA helix d(CGATCG)2: stereostructural studies by 2D NMR spectroscopy.
PublicationImidazoacridinone C-1311 (Symadex®) is a powerful antitumor agent, which successfully made its way through the Phase I clinical trials and has been recommended for Phase II few a years ago. It has been shown experimentally that during the initial stage of its action C-1311 forms a relatively stable intercalation complex with DNA, yet it has shown no base-sequence specificity while binding to DNA. In this paper, the d(CGATCG)2:C-1311...
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Laser Welding of UNS S33207 Hyper-Duplex Stainless Steel to 6061 Aluminum Alloy Using High Entropy Alloy as a Filler Material
PublicationThe high entropy alloy (HEA) filler used during the fabrication method determines the reliability of HEAs for steel-aluminum dissimilar alloy configuration. HEAs have a direct impact on the formation of intermetallic compounds (IMC) formed by the interaction of iron (Fe) and aluminum (Al), and influence the size of the joint’s interaction zone. A novel welding process for Fe-Al alloy joints was developed to prevent the development...
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Thermal cooling process by nanofluid flowing near stagnating point of expanding surface under induced magnetism force: A computational case study
PublicationThis paper is dedicated to the exam of entropy age and research of the effect of mixing nanosolid additives over an extending sheet. In this review, Newtonian nanofluid version turned into researched at the actuated appealing field, heat radiation and variable heat conductivity results. With becoming modifications, the proven PDEs are moved into popular differential situations and paintings mathematically making use of a specific...
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Autogenous Fiber Laser Welding of 316L Austenitic and 2304 Lean Duplex Stainless Steels
PublicationThis study presents results of experimental tests on quality of dissimilar welded joints between 316L austenitic and 2304 lean duplex stainless steels, welded without ceramic backing. Fiber laser welded butt joints at a thickness of 8 mm were subjected to non‐destructive testing (visual and penetrant), destructive testing (static tensile test, bending test, and microhardness measurements) and structure observations (macro‐ and...
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Nanosilver-loaded PMMA bone cement doped with different bioactive glasses – evaluation of cytocompatibility, antibacterial activity, and mechanical properties
PublicationNanosilver-loaded PMMA bone cement (BC-AgNp) is a novel cement developed as a replacement for conventional cements. Despite favorable properties and antibacterial activity, BC-AgNp still lacks biodegradability and bioactivity. Hence, we investigated the doping with bioactive glasses (BGs) to create a new bioactive BC characterized by time-varying porosity and gradual release of nanosilver. The BC Cemex was used as the base material...
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Catalytic Mechanism of Non-Target DNA Cleavage in CRISPR-Cas9 Revealed by Ab Initio Molecular Dynamics
PublicationCRISPR-Cas9 is a cutting-edge genome editing technology, which uses the endonuclease Cas9 to introduce mutations at desired sites of the genome. This revolutionary tool is promising to treat a myriad of human genetic diseases. Nevertheless, the molecular basis of DNA cleavage, which is a fundamental step for genome editing, has not been established. Here, quantum–classical molecular dynamics (MD) and free energy methods are used...
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Novel Versatile Topologies and Design Optimization of Wide-Bandstop Frequency Selective Surfaces for X-Band, Ku-Band and Millimeter-Wave Applications
PublicationNovel designs of frequency selective surface (FSS) are presented for wideband applications in X, Ku and mmWave (millimeter Wave) bands. Two identical metallic layers of FSS are imprinted on both sides of the RO4003 substrate. The geometry parameters are optimized to maximize the bandstop at the specified in-band maximum transmission level of –10 dB; satisfaction of the latter condition is enforced through appropriate formulation...
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FPGA implementation of the multiplication operation in multiple-precision arithmetic
PublicationAlthough standard 32/64-bit arithmetic is sufficient to solve most of the scientific-computing problems, there are still problems that require higher numerical precision. Multiple-precision arithmetic (MPA) libraries are software tools for emulation of computations in a user-defined precision. However, availability of a reconfigurable cards based on field-programmable gate arrays (FPGAs) in computing systems allows one to implement...
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Multi-Criteria Approach in Multifunctional Building Design Process
PublicationThe paper presents new approach in multifunctional building design process. Publication defines problems related to the design of complex multifunctional buildings. Currently, contemporary urban areas are characterized by very intensive use of space. Today, buildings are being built bigger and contain more diverse functions to meet the needs of a large number of users in one capacity. The trends show the need for recognition of...
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Determinants of trade balance in Polish and Czech manufacturing sectors
PublicationResearch background: A strong industrial base is essential for achieving long-term sustainable economic growth and export competitiveness. In that sense, manufacturing remains a significant contributor to exports in the CEE countries. However, its role and its influence vary between CEE economies and change over time. Purpose of the article: The main objective of this paper is to compare the determinants of the international competitiveness,...
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Stormwater runoff in the urbanized coastal basin of Gdańsk Urbanized basin of Gdańsk
PublicationAnthropopressure strongly affects the primal water cycle. Alternation of the natural basins imposes changes of drainage patterns, reduction of bioretention, infiltration and base flow. As a result the overland flow predominates and greater runoff rates flow into storm water collection systems and reservoirs. Moreover changing climatic conditions increase the frequency of rapid extreme weather events. Infrastructures of urban areas...
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Modeling and control of a redundantly actuated variable mass 3RRR planar manipulator controlled by a model-based feedforward and a model-based-proportional-derivative feedforward–feedback controller
PublicationIn the paper, dynamics of a complex mechatronics system is considered. A redundantly actuated planar manipulator is the base of the mechanical part of it. It is a 3RRR 1 platform based parallel manipulator. To control its trajectory, a model-based feedforward controller is employed. Three aspects are fundamental in the presented investigations. The first focus is on development of an accurate numerical model used to solve the inverse...
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Earthquake-induced pounding between equal height multi-storey buildings considering soil-structure interaction
PublicationThe present paper investigates the coupled effect of the supporting soil flexibility and pounding between neighbouring, insufficiently separated equal height buildings under earthquake excitation. Two adjacent three-storey structures, modelled as inelastic lumped mass systems with different structural characteristics, have been considered in the study. The models have been excited using a suit of ground motions with different peak...
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Opitmalising Human Development Index with sensitivity analysis
PublicationResearch background: Composite indicators are commonly used not only to measure economic development, the standard of livin g, competitiveness, fairness, effectiveness but are also willingly implemented in to many different fields. How- ever, it seems that in most cases the variable weig hting procedure is avoided or erroneous since in most cases so-called “wights by belief” are...
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Probabilistic seismic assessment of RC box-girder highway bridges with unequal-height piers subjected to earthquake-induced pounding
PublicationThis paper uses the probabilistic seismic assessment to study the effects of pounding and irregularity on the seismic behavior of typical concrete box-girder bridges with four levels of altitudinal irregularity. To extend the results for all bridges in the same class, uncertainty related to the earthquake, structural geometries, and materials are considered. Pounding is likely to take place in two cases: the first one concerns...
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Is It Right To Predict Cutting Forces On The Basis Of Wood Density?
PublicationSeveral properties of wood can be correlated to wood density. It is widely accepted that the cutting power requirements are following this general assumption. Therefore, according to classic literature sources available for determination of the cutting power for both band- and circular- sawing machines, the cutting power requirements (and/or cutting forces) are computed as a function of the wood specific gravity SG. It was shown...
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Stormwater and snowmelt runoff storage control and flash flood hazard forecasting in the urbanized coastal basin.
PublicationCity of Gdańsk is located in a coastal region where changing climatic conditions increase the frequency of extreme weather events. Developing urbanization affects the hydrology of natural basins by simplification of the drainage system and reduction of infiltration and base flow. Consequently greater runoff rates flow into storm water collection systems, reservoirs and surrounding water bodies. Not only infrastructures of urban...
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Analiza i badania pomiarowe dokładności lokalizowania terminali ruchomych w sieciach komórkowych
PublicationJakość oferowanych przez operatorów sieci komórkowych usług o wartości wzbogaconej (usług dodanych) zależy od efektywności metod estymacji położenia geograficznego terminala ruchomego MS (Mobile Station). Dokładność istniejących w sieciach komórkowych metod lokalizacyjnych jest niewystarczająca, szczególnie w odniesieniu do usług związanych z wywołaniem w niebezpieczeństwie. Obecnie, do najbardziej popularnej w sieciach komórkowych...
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Effect of Processing Parameters on Strength and Corrosion Resistance of Friction Stir-Welded AA6082
PublicationThe friction stir welding method is increasingly attracting interest in the railway sector due to its environmental friendliness, low cost, and ease of producing high-quality joints. Using aluminum alloys reduces the weight of structures, increasing their payload and reducing fuel consumption and running costs. The following paper presents studies on the microstructure, strength, and corrosion resistance of AA6082 aluminum alloy...
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Standard and modified falling mass impact tests on preplaced aggregatefibrous concrete and slurry infiltrated fibrous concrete
PublicationAlthough several studies have been conducted to evaluate the impact response of concrete using theAmerican Concrete Institute (ACI) 544-2R falling mass impact test, the variations in test results are themain drawback of this testing method. This study aims to reduce the variations in experimental impacttest results by introducing two simple test setup modifications; (1) using coarse or fine aggregate bed-ding as an alternative...
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Mathematical approach to design 3D scaffolds for the 3D printable bone implant
PublicationThis work demonstrates that an artificial scaffold structure can be designed to exhibit mechanical properties close to the ones of real bone tissue, thus highly reducing the stress-shielding phenomenon. In this study the scan of lumbar vertebra fragment was reproduced to create a numerical 3D model (this model was called the reference bone sample). New nine 3D scaffold samples were designed and their numerical models were created....
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Review and evaluation of cold recycling with bitumen emulsion and cement for rehabilitation of old pavements
PublicationThe article presents Polish experience with cold recycling of asphalt pavements with theusage of bituminous emulsion and cement. In the 1990s numerous roads in Polandrequired immediate reinforcement due to their significant degradation. Implementation ofthe cold recycling technology was one of the solutions to this problem. Cold recycledmixtures containebeside the recycled asphalt pavement and aggregateetwo differenttypes of binding...
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Network effects—do they matter for digital technologies diffusion?
PublicationPurpose The main research target of this paper is to capture the network effects using the case of mobile cellular telephony, identified in European telecommunication markets, and its determinants enhancing the process of digital technologies diffusion. Design/methodology/approach This research relies on panel and dynamic panel regression analysis. The empirical sample covers 30 European countries, and the period for the analysis...
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Methodology for implementing power plant efficiency standards for power generation: potential emission reduction
PublicationSome methods of generating power such as power generation through coal, natural gas, oil result in inevitable emissions of greenhouse gases. While power generation is necessary due to its increasing demand, it is important for power companies to generate their power in an efcient manner to reduce its efect on the environment. One of the most efective ways of tackling inefciency issues is through the implementation of efciency standard....
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Data augmentation for improving deep learning in image classification problem
PublicationThese days deep learning is the fastest-growing field in the field of Machine Learning (ML) and Deep Neural Networks (DNN). Among many of DNN structures, the Convolutional Neural Networks (CNN) are currently the main tool used for the image analysis and classification purposes. Although great achievements and perspectives, deep neural networks and accompanying learning algorithms have some relevant challenges to tackle. In this...
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Experimental study on the seepage flow through the ice jam
PublicationIn light of the observed climate change, there is a need for better understanding of river ice processes for managing water resources in the cold regions. Ice jams produce significant resistance which may cause rise of water level and flooding. The jam resistance is only referred to the roughness of its underside, and this approach lead to exceptional roughness coefficients which has no physical explanation. Number of evidences...
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NetBaltic System-Heterogenous Wireless Network for Maritime Communications
PublicationIn case of maritime communications, we observe a growing interest in deployment of multitask satellite-based solutions and development of new maritime-specific systems intended for improvements in safety of e-navigation. Analysis of different types of currently used maritime communication systems leads, however, to a conclusion that neither global and still very expensive satellite systems nor cheaper, but short-ranged transmission...
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Strength analysis of a large-size supporting structure for an offshore wind turbine
PublicationThe offshore wind power industry is the branch of electric energy production from renewable sources which is most intensively developed in EU countries. At present, there is a tendency to install larger-power wind turbines at larger distances from the seashore, on relatively deep waters. Consequently, technological solutions for new supporting structures intended for deeper water regions are undergoing rapid development now. Various...
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Investigation of environmental influences to the precise GNNS solutions
PublicationThe results presented in this paper concern investigation of environmental influences to GNNS coordinates on the example of ASG-EUPOS network. The problem of the impact of environmental effects is crucial for observing gravity. Satellite systems are not as susceptible to changes in local hydrology or atmospheric effects, although significant influences are clearly visible in the change of coordinates. The authors analyzed daily...
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Phytoplankton communities of polar regions–Diversity depending on environmental conditions and chemical anthropopressure
PublicationThe polar regions (Arctic and Antarctic) constitute up to 14% of the biosphere and offer some of the coldest and most arid Earth's environments. Nevertheless several oxygenic phototrophs including some higher plants, mosses, lichens, various algal groups and cyanobacteria, survive that harsh climate and create the base of the trophic relationships in fragile ecosystems of polar environments. Ecosystems in polar regions are characterized...
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Conserved motifs of MutL proteins
PublicationtThe MutL protein is best known for its function in DNA mismatch repair (MMR). However, there isevidence to suggest that MutL is not only the linker connecting the functions of MutS and MutH in MMR,but that it also participates in other repair systems, such as Very Short Patch (VSP), Base Excision (BER)and Nucleotide Excision Repair (NER). This study set out to identify the most highly conserved aminoacid sequence motifs in MutL...
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New 2-[(4-Amino-6-N-substituted-1,3,5-triazin-2-yl)methylthio]-N-(imidazolidin-2-ylidene)-4-chloro-5-methylbenzenesulfonamide Derivatives, Design, Synthesis and Anticancer Evaluation
PublicationIn the search for new compounds with antitumor activity, new potential anticancer agents were designed as molecular hybrids containing the structures of a triazine ring and a sulfonamide fragment. Applying the synthesis in solution, a base of new sulfonamide derivatives 20–162 was obtained by the reaction of the corresponding esters 11–19 with appropriate biguanide hydrochlorides. The structures of the compounds were confirmed...
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New generation of the satellite hydraulic pumps
PublicationHydraulic satellite machines are known and produced in many versions, recognizable by the number of humps on their inner rotor and external gear, and therefore by the number of cooperating gears (satellites). All known shapes were however designed on the base of preliminary assumption that rotor’s and external gear’s pitch lines are formed by merging arcs, tangent to each other in the. This assumption makes calculations easier,...
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Influence of several biodegradable components added to pure and nanosilver-doped PMMA bone cements on its biological and mechanical properties
PublicationAcrylic bone cements (BC) are wildly used in medicine. Despite favorable mechanical properties, processability and inject capability, BC lack bioactivity. To overcome this, we investigated the effects of selected biodegradable additives to create a partially-degradable BC and also we evaluated its combination with nanosilver (AgNp). We hypothesized that using above strategies it would be possible to obtain bioactive BC. The Cemex...
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Appunti di corporate governance
PublicationIl libro pone la proprietà al centro di tutte le scelte rilevanti che l’impresa compie: in particolare affronta il «problema» del governo il tema della corporate governance dalla prospettiva della proprietà e in un’accezione più ampia e articolata rispetto agli studi di matrice anglosassone. In questo contesto, si analizza il tema delle relazioni tra proprietà, governo corporate governance e strategia corporate delle imprese, con...
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Displacement piles - classification and methods for the calculation of bearing capacity.
PublicationDisplacement piles belong to a group of technologies whose main idea is to install or make a pile without extracting ground material. According to definition, contained in PN-EN:1997-1:2008, displacement piles should be considered as driven, pressed in using vibrators and made with the use of spread augers. The classification of piles used so far with regard to the technology of execution is modified. An additional element is the...
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The effect of exogenous application of methyl jasmonate on the lipid and carbohydrate content and composition of winter triticale (Triticosecale Wittm.) grain and the severity of fungal infections in triticale plants and grain
PublicationKernels of winter triticale (Triticosecale Wittm. cv. Dinaro) were analyzed. In the autumn of 2015, the effect of methyl jasmonate (MJ) on the germination of triticale kernels and the development of triticale seedlings was analyzed in a laboratory before kernels were sown in experimental plots. Kernels harvested from plots in August 2016 were analyzed to determine their lipid and carbohydrate content and composition and the severity...
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The interaction between bacterial abundance and selected pollutants concentration levels in an arctic catchment (southwest Spitsbergen, Svalbard)
PublicationPersistent organic pollutants (POPs) have been a topic of interest in environmental sciences for > 60 years. POPs in the Arctic have been investigated since the 1970s, when first atmospheric measurements revealed the presence of these pollutants in the polar regions. Major contaminant transport routes to the Arctic include atmospheric and oceanic transport, as well as inflow from rivers and sea ice. The sources of pollutants, such...
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DoA Estimation Using Reconfigurable Antennas in Millimiter-Wave Frequency 5G Systems
PublicationTo achieve low latency and high throughputs, future 5G systems will have to utilize complex antenna systems able to provide beamforming and direction-of-arrival (DoA) estimation capabilities. Most of the concepts available in the literature rely on analog or digital beamforming, which is well developed and can be used both at a base station and in a user terminal. However, in applications, in which...
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Interworking and Cross-layer Service Discovery Extensions for IEEEE802.11s Wireless Mesh Standard
PublicationWith the rapid popularization of mobile end-user electronic devices wireless network technologies begin to play a crucial role as networks access technologies. While classic point-to-multipoint wireless access systems, based on fixed infrastructure of base stations providing access to clients, remain the main most popular solution, an increasing attention is devoted to wireless mesh systems, where each connecting client can extend...
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Dendron to Central Core S1–S1 and S2–Sn (n>1) Energy Transfers in Artificial Special Pairs Containing Dendrimers with Limited Numbers of Conformations
PublicationTwo dendrimers consisting of a cofacial free-base bisporphyrin held by a biphenylene spacer and functionalized with 4-benzeneoxomethane (5-(4-benzene)tri-10,15,20-(4-n-octylbenzene)zinc(II)porphyrin) using either five or six of the six available meso-positions, have been synthesized and characterized as models for the antenna effect in Photosystems I and II. The presence of the short linkers, -CH2O-, and long C8H17 soluble side...
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Two small RNAs conserved in Enterobacteriaceae provide intrinsic resistance to antibiotics targeting the cell wall biosynthesis enzyme glucosamine-6-phosphate synthase
PublicationFormation of glucosamine-6-phosphate GlcN6P) by enzyme GlcN6P synthase (GlmS) represents the first step in bacterial cell envelope synthesis. In Escherichia coli, expression of glmS is controlled by small RNAs (sRNAs) GlmY and GlmZ. GlmZ activates the glmS mRNA by base-pairing. When not required, GlmZ is bound by adapter protein RapZ and recruited to cleavage by RNase E inactivating the sRNA. The homologous sRNA GlmY activates...