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Effect Of Resveratrol And Quercetin On Telomerase Regulation In Cancer Cells And Their Anti-Cancer Potential
PublicationTelomeres and telomerase are nowadays one on targets for anticancer therapy. Telomerase is expressed in ~90% of human cancer cell lines and tumor specimens, whereas its enzymatic activity is not detectable in most human somatic cells. Was found that some dietary compounds can modulate telomerase activity in cancer cells. This review summarizes the current knowledge about the effects of resveratrol and quercetin on telomerase regulation...
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Segmentation-Based BI-RADS ensemble classification of breast tumours in ultrasound images
PublicationBackground: The development of computer-aided diagnosis systems in breast cancer imaging is exponential. Since 2016, 81 papers have described the automated segmentation of breast lesions in ultrasound images using arti- ficial intelligence. However, only two papers have dealt with complex BI-RADS classifications. Purpose: This study addresses the automatic classification of breast lesions into binary classes (benign vs. ma- lignant)...
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Tin Oxide Encapsulated into Pyrolyzed Chitosan as a Negative Electrode for Lithium Ion Batteries
PublicationTin oxide is one of the most promising electrode materials as a negative electrode for lithium-ion batteries due to its higher theoretical specific capacity than graphite. However, it suffers lack of stability due to volume changes and low electrical conductivity while cycling. To overcome these issues, a new composite consisting of SnO2 and carbonaceous matrix was fabricated. Naturally abundant and renewable chitosan was chosen...
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Influence of Natural Conditions on the Imaging of the Bottom of the Gdańsk Bay by Means of the Side Scan Sonar
PublicationThe interest in underwater resources is the reason for the development of modern hydroacoustic systems, including side sonars, which find numerous applications such as: research of seabed morphology and sediment characteristics, preparation of sea sediment maps, and even in special cases of biocenoses such as sea grass meadows, detection of specific targets at the bottom such as shipwrecks, mines, identification of suitable sites...
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Characterization of a cryptic plasmid pSFKW33 from Shewanella sp. 33b
PublicationA cryptic plasmid pSFKW33 from psychrotrophic bacterium Shewanella sp. 33B, an isolate from the Gulf of Gdansk (the Baltic Sea), was sequenced and characterized. It is an 8021 bpcircular molecule with 38% GC content, which shows a distinctive nucleotide sequence without homology to other known plasmids. The nucleotide sequence analysis predicts eight open reading frames. The deduced amino acid sequence of ORF-1 shared significant...
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Comparison of thresholding algorithms for automatic overhead line detection procedure
PublicationThe article presents an overview of the thresholding algorithms. It compares the algorithms proposed by Pun, Kittler, Niblack, Huang, Rosenfeld, Remesh, Lloyd, Riddler, Otsu, Yanni, Kapur and Jawahar. Additionally, it was tested how the tuning of the Pun, Jawahar and Niblack methods affects the thresholding efficiency and proposed a combination of the Pun algorithm with a priori algorithm. All presented algorithms have been implemented...
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The synthesis and structure of a potential immunosuppressant: N-mycophenoyl malonic acid dimethyl ester
PublicationThe synthesis of a potential immunosuppressant, i.e. dimethyl ester of N-mycophenoyl malonic acid was optimized in the reaction of mycophenolic acid (MPA) with amino malonic dimethyl ester in the presence of propanephosphonic anhydride (T3P) as a coupling reagent. The structural properties of the obtained MPA derivative were investigated by NMR, MS and single crystal X-ray diffraction methods. Theoretical considerations of conformational...
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Unités phraséologiques au pays de la traduction: transfert des collocations nomino-adjectivales avec le lexème «femme» dans la traduction de la littérature houellebecquienne du français vers l’italien et le polonais
PublicationThe present paper examines the transfer of nomino-adjectival collocations based on the word ‘femme’ (‘woman’) in the literary translation from French into Italian and Polish. The lexical connection analysed in the article can be defined as the habitual juxtaposition of a word with another word (or words) that has a significant frequency in a given language. The research corpus comprises seven Michel Houellebecq’s novels written...
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How to deal with knowledge in small companies? Defining emergent KM approach
PublicationThis paper examines the concept of emergent KM approach in small companies. The origins of consideration are grounded in the theory of strategic management literature and in particular in the distinction between deliberate versus emergent approach towards strategic planning. Using the methodology of case study, we carried out an explorative research to analyse the characteristics of KM approach in two small companies located in...
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Graphene hydrogels with embedded metal nanopatricles as efficient catalysts in 4-nitrophenol reduction and methylene blue decolorization
PublicationSynthesis and characterization of the graphene hydrogels with three different metallic nanoparticles, that is Au, Ag and Cu, respectively is presented. Synthesized in a one-pot approach graphene hydrogels with embedded metallic nanoparticles were tested as heterogeneous catalysts in a model reaction of 4-nitrophenol reduction. The highest activity was obtained for graphene hydrogel with Cu NPs and additional reaction of methylene...
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An odor-sensing system - powerful technique for foodstuff studies
PublicationThis work examines gas sensor array technology combined with multivariate data processing methods and demonstrates a promising potential for rapid, non-destructive analysis of food. Main attention is focused on detailed description of sensor used in e-nose instruments, construction, and principle of operation of these systems. Moreover, this paper briefly reviews the progress in the field of artificial olfaction and future trends...
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Estimating the Impact of Globalization on International Competitiveneess : a Multidimensional Approach
PublicationThis paper examines the effects of globalization on international competitiveness (IC). The aggregated and disaggregated indices of IC (World Economic Forum) and globalization (KOF) for 132 countries in 2008 are used for the estimation of regression functions. The results show that globalization positively influences IC at the highest aggregation levels of the indices used. Social and political globalization affect IC at intermediate...
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UK travel agents’ evaluation of eLearning courses offered by destinations: an exploratory study.
PublicationThis study aims to develop an understanding of the use of e-learning courses created for travel agents by Destination Management Organizations (DMOs). It explores agents’ perceptions of such courses. The research examines the views of 304 UK-based travel agents using online survey and investigates whether age, sex, type of agency, work experience, and educational level have influence on e-learning uptake. The satisfaction of travel...
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Forecasted climate changes and their influence on cities and regions in 2050 in terms of extreme hydrological events
PublicationGlobal climate change is a problem which arises numerous theories and uncertainties, especially in terms of speculated human impact. Independent from the fact, what is the main driver for the changes, some of the climate shifts are visible already nowadays. Both contemporary and future cities will have to face such problems. Although climate change may cause numerous effects on different fields, a special stress in this article...
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SEMANTIC ANALYSIS ALGORITHMS FOR KNOWLEDGE WORKERS SUPPORT
PublicationThe paper examines various aspects of text analysis application for knowledge worker’s activity realization. Conclusions are drawn about the relevance and importance of processing the non-structured textual information in order to increase knowledge worker’s efficiency, as well as their awareness in different branches of science. The paper considers the existing algorithms of texts semantic analysis as the sphere of documents topical...
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Mangiferin Affects Melanin Synthesis by an Influence on Tyrosinase: Inhibition, Mechanism of Action and Molecular Docking Studies
PublicationMangiferin is a strong antioxidant that presents a wide range of biological activities. The aim of this study was to evaluate, for the first time, the influence of mangiferin on tyrosinase, an enzyme responsible for melanin synthesis and the unwanted browning process of food. The research included both the kinetics and molecular interactions between tyrosinase and mangiferin. The research proved that mangiferin inhibits tyrosinase...
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Low-Profile Interdigitated UHF RFID Tag Antenna for Metallic Objects
PublicationThis article presents a novel miniature interdigitated ultra-high frequency (UHF) radio frequency identification (RFID) tag antenna that can be placed on metallic objects. The tag structure comprises two horizontal strip lines, each loaded with seven identical open stubs, and an integrated circuit (IC) chip connected directly to the feed lines in the middle of the structure. The perfect match to the IC chip’s impedance is realized...
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The Effect of Fly Ash Microspheres on the Pore Structure of Concrete
PublicationThe fly ash microspheres (FAMs) formed during the mineral transformation stage in coal combustion are hollow spherical particles with a density less than water. This paper presents the results of X‐ray micro‐computed tomography and an automatic image analysis system of the porosity in the structure of hardened concrete with microspheres. Concrete mixtures with ordinary Portland cement and two substitution rates of cement by microspheres—5%...
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GIS-based hydrodynamic modeling for urban flood mitigation in fast-growing regions: a case study of Erbil, Kurdistan Region of Iraq
PublicationFloods threaten urban infrastructure, especially in residential neighborhoods and fast-growing regions. Flood hydrodynamic modeling helps identify flood-prone locations and improve mitigation plans' resilience. Urban floods pose special issues due to changing land cover and a lack of raw data. Using a GIS-based modeling interface, input files for the hydrodynamic model were developed. The physical basin's properties were identified...
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General, Mild, and Metal-Free Functionalization of Indole and Its Derivatives Through Direct C3-Selenylation
PublicationA very mild method for the introduction of functionalized alkylselenyl group at C-3 position of the indole ring was developed. The proposed procedure consists of an electrophilic substitution of indole and its derivatives with bis(O,O-diisopropoxyphosphorothioyl) diselenide and subsequent cleavage of the P–Se bond with tetrabutylammonium fluoride in the presence of various electrophilic reagents. This method can be successfully...
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Non-Isocyanate-Based Waterborne Polyurethanes
PublicationNon-isocyanate polyurethanes (NIPUs) are a greener alternative for the conventional polyurethanes synthesized using toxic and moisture-sensitive di- or polyisocyanates. The most often described method of NIPU synthesis involves the reaction of five-membered cyclic carbonates with amines, and resulting polymers containing primary and secondary hydroxyl groups (so they are also known as polyhydroxyurethanes), which can be further...
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Computer application for railway track realignment
PublicationThe topic of this article is the issue of railway track realignment. For this purpose, a computer software application was created that supports computations and generates a report needed for regulation of the trajectory of the railway. This program gives the ability to import data from measurement of the railway trajectory and then perform the calculation of the mathematical realignment. The result of this calculation is the basis...
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Design of Microstrip UWB Balun Using Quasi-TEM Approach Aided by the Artificial Neural Network
PublicationThe design procedure for UWB balun realized in the microstrip technology is proposed in the paper. The procedure applies Artificial Neural Network which corrects the dimensions of the approximate design found by appropriate scaling of the dimensions of the prototype. The scale coefficients for longitudinal and transverse dimensions of microstrip lines are determined from electromagnetic modeling based on transmission line equations....
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Crystal Structure of N-(2-Benzoyl-4,5-dimethoxyphenethyl)-2-phenylacetamide
PublicationThe crystal structure of N-(2-benzoyl-4,5-dimethoxyphenethyl)-2-phenylacetamide indicates that the compound crystallizes in the monoclinic C2/c space group with eight molecules in the unit cell. The heteroatoms from the amide group form a chain of intermolecular N-H ··· O hydrogen bonds propagating along the b axis. The carbonyl group from the benzoyl substituent participates in short contacts with two H-atoms from the ethyl or...
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Does source matter? Generation of investment expenditures by different types of local government revenues
PublicationThe purpose of the article was to investigate the impact of the three fundamental statutory categories of budget revenues, i.e. own revenues, general subsidies and specific grants on the size of investments made by local government units in Poland. The subject scope included the local government subsector in its entirety, as well as divided into 4 groups: communes (gminas), cities with powiat rights, districts (powiats) and province...
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Correction of determined coordinates of railway tracks in mobile satellite measurements
PublicationThis article examines one of the basic issues related to the technique of mobile satellite measurements in railway tracks. This problem concerns the correction of the determined coordinates of the track centerline. The need to perform this operation results from the GNSS receivers positioning at a certain height above the level of the existing track axis, leading to longitudinal and lateral shifts of antennas. The key problem here...
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Solid-contact lead(II) ion-selective electrodes for potentiometric determination of lead(II) in presence of high concentrations of Na(I), Cu(II), Cd(II), Zn(II), Ca(II) and Mg(II)
PublicationLead and its compounds are a serious threat to the environment. Monitoring of this toxic heavy metal is a driving force for the continuous development of novel lead(II) ionophores to be applied in ion-selective electrodes. In this work a highly selective lead(II) ionophore, namely 25,26,27,28-tetrakis(piperidinylthiocarbonylmethylene)-p-tert-butylcalix[4]arene, was used in solid-contact ion-selective electrodes for determination...
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Corrosion monitoring as a factor increasing the safety of hydrotechnical infrastructure
PublicationWater distribution systems at KGHM S.A. are of great importance for the efficient production of copper and environmental protection. For failures leading to perforation and leakage, the corrosion processes are responsible. This paper aims to assess corrosion on the basis of the analysis of the exposure of the Hydrotechnical Plant pipelines. To this end, the system of transfer and deposition of post-flotation waste as well as the...
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Structural features responsible for control of the eukaryotic GlcN-6-P synthase activity
PublicationGlucosamine-6-phosphate (GlcN-6-P) synthase is responsible for catalysis of the first and practically irreversible step in hexosamine metabolism. As UDP-GlcNAc, the final product of the hexosamine path, constitutes one of the essential substrates for assembly of bacterial and fungal cell walls, the enzyme is an interesting target for antimicrobial therapy.The structure of E. coli enzyme, known since 2001, forms a dimer of two identical...
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Identification and molecular modeling of a novel lipase from an Antarctic soil metagenomic library.
PublicationIn this work, we present the construction of a metagenomic library in Escherichia coli using pUC19 vector and environmental DNA directly isolated from Antarctic topsoil and screened for lipolytic enzymes. The screening on agar supplemented with olive oil and rhodamine B revealed one clone with lipolytic activity (Lip1) out of 11,000 E. coli clones. This clone harbored a plasmid, pLip1, which has an insert of 4722 bp that has been...
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Synthesis and Biological Evaluation of Acridine/Acridone Analogs as Potential Anticancer Agents
PublicationAcridine and acridone analogues were prepared by Ullmann condensation and then cyclization reaction. As a result of nucleophilic substitution reaction 1-nitro-9-phenoxyacridine or 1-chloro-4-nitro-9(10H)-acridone with the corresponding peptides, the planned acridine derivatives (10a-c, 12, 17-a-d, 19) have been obtained. The cytotoxic activity of the newly obtained analogs were evaluated against melanotic (Ma) and amelanotic (Ab)...
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Selection of circuit geometry for miniaturized microwave components based on concurrent optimization of performance and layout area
PublicationThe paper presents a framework for automated EM-driven circuit geometry selection of miniaturized microwave components. Selection of a particular layout is based directly on miniaturization rates achieved for a set of candidate circuit geometries. Size reduction of the considered structures is obtained by replacing their main building blocks (i.e., conventional transmission lines) with slow-wave composite cells and meander lines....
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Electron ionization and low energy electron attachment to molecules of biological interest
PublicationEthylenediaminetetraacetic acid (EDTA) and 2-amino-2-(hydroxymethyl)-1,3-propanediol (TRIS) were investigated by electron impact ionization and low energy electron attachment. Both compounds are components of biological buffers and often are used as DNA stabilizers in irradiation studies. hus it is of a great importance to understand their potential interactions with radiation. Our results revealed that at least one of them, EDTA, may...
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Electron ionization and low energy electron attachment to molecules of biological interest
PublicationEthylenediaminetetraacetic acid (EDTA) and 2-amino-2-(hydroxymethyl)-1,3-propanediol (TRIS) were investigated by electron impact ionization and low energy electron attachment. Both compounds are components of biological buffers and often are used as DNA stabilizers in irradiation studies. hus it is of a great importance to understand their potential interactions with radiation. Our results revealed that at least one of them, EDTA, may...
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NEW CONCEPT OF HYBRID PROPULSION WITH HYDROSTATIC GEAR FOR INLAND WATER TRANSPORT
PublicationThe article presents the development of author’s concept of a diesel/hydraulic propulsion system for inland watercraft. Due to specific nature of vessel navigation on rivers, classical propulsion systems with shaft lines can be effectively replaced by systems with hydraulic power transmission. A solution is also presented of a hybrid design with extra electric port having the form of a pumping system driven from a battery of accumulators....
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The Crisis of Marketing Communication in the Era of Social Media
PublicationThe articles examines the widely discussed in literature the problem of marketing communication crisis resulting from the changes of the environment. These changes generate both new problems and also new solutions, e.g. social media. The practicioners are pursuing both effective and efficient solutions, in relation to the difficulties encountered while achieving market objectives via traditional methods and channels. In accordance...
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Critical perspectives on media architecture: is it still possible to design projects without negatively affecting urban nighttime environments and will the future remain dynamic, bright and multi-colored?
PublicationNowadays, due to advances in electrical devices, new digital media, lighting, information and communication technologies, cities are being used 24/7. The paper discusses critical aspects of Media Architecture in the context of public spaces as well as urban nighttime environments from the perspective of a practising lighting architect. The author examines recent issues of negative design approaches and presents proposals for improving...
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Dataset Characteristics and Their Impact on Offline Policy Learning of Contextual Multi-Armed Bandits
PublicationThe Contextual Multi-Armed Bandits (CMAB) framework is pivotal for learning to make decisions. However, due to challenges in deploying online algorithms, there is a shift towards offline policy learning, which relies on pre-existing datasets. This study examines the relationship between the quality of these datasets and the performance of offline policy learning algorithms, specifically, Neural Greedy and NeuraLCB. Our results...
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Innovative strategies: Combining treatments for advanced wastewater purification
PublicationWater scarcity is a pressing global challenge, driving the urgent need for effective wastewater treatment solutions. With untreated wastewater extensively employed, particularly in agriculture, the significance of proper treatment becomes evident, as it presents a more practical and ecologically responsible alternative. This chapter explores the diverse treatment approaches encompassing chemical, physical, and biological methods,...
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Architecture of ecumenical spaces in public buildings in the 21st century: Links among the architecture of multi-faith spaces, their names, and the functions they serve in Polish airports
PublicationThis study explores the architecture and arrangement of prayer spaces in public buildings. It examines whether Polish airports have prayers spaces and whether a correlation exists between the name (e.g., “multi-faith space,” “place of prayer,” and “place of focus”) and design. The study is supported by analyses of ecumenical spaces, which have recently been brought into service andwhere a visible symbiosis exists between their...
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Multiple access in ad-hoc wireless LANs with noncooperative stations
PublicationA class of contention-type MAC protocols (e.g., CSMA/CA) relies on random deferment of packet transmission, and subsumes a deferment selection strategy and a scheduling policy that determines the winner of each contention cycle. This paper examines contention-type protocols in a noncooperative an ad-hoc wireless LAN setting, where a number of stations self-optimise their strategies to obtain a more-than-fair bandwidth share. Two...
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Efficient Synthesis of Functionalized Unsymmetrical Dialkyl Trisulfanes
PublicationWe have developed a convenient method for the synthesis of functionalized unsymmetrical dialkyl trisulfanes under mild conditions in very good yields. The designed method is based on the reaction of (5,5-dimethyl-2-thioxo-1,3,2-dioxaphosphorinan-2-yl)-disulfanyl derivatives with alkyl disulfanyl anions generated in situ from S-acetyl disulfanyl derivatives and sodium methoxide. The developed method allows for the preparation of...
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Materials for Mediator-free Electron Transfer in the Enzymatic Electrodes of Biobatteries and Biofuel Cells
PublicationWe present functionalization of single-walled carbon nanotubes (SWCNTs) and their application in the enzymatic fuel cells construction. SWCNTs were covalently modified with different types of aromatic moieties. Free radical reaction was employed to create direct carbon-carbon bond between moiety and SWCNTs. In second approach functionalization takes place through amide bonding. Functionalized SWCNTs were characterized by spectroscopy...
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An efficient and convenient synthesis of unsymmetrical disulfides from thioacetates
PublicationWe have developed convenient methods for the synthesis of functionalized unsymmetrical dialkyl disulfides under mild conditions in very good yields. The designed method is based on the reaction of (5,5-dimethyl-2-thioxo-1,3,2-dioxaphosphorinan-2-yl)-disulfanyl derivatives 1 with functionalized alkyl thiolate anions, generated in situ from thioacetates2and sodium methoxide or butylamine. The developed method allows the preparation...
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Synthesis of 3-Carbamoyl b-Lactams via Manganese(III)-Promoted Cyclization of N-Alkenylmalonamides
PublicationManganese(III)-promoted cyclization of N-alkenylmalonamides (¼N-alkenylpropanediamides) gave 3-(aryl/(alkylamino)carbonyl) b-lactams as well as 3-(aryl/(alkylamino)thiocarbonyl) b-lactams. The relative configuration of the obtained products was unambiguously determined by X-ray crystallography. The proposed method is very useful for the one-pot synthesis of a number of 3-(aryl/ (alkylamino)carbonyl) b-lactams, especially those...
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Assessment and design of greener deep eutectic solvents – A multicriteria decision analysis
PublicationDeep eutectic solvents (DES) are often considered as green solvents because of their properties, such as negligible vapor pressure, biodegradability, low toxicity or natural origin of their components. Due to the fact that DES are cheaper than ionic liquids, they have gained many applications in a short period of time. However, claims about their greenness sometimes seem to be exaggerated. Especially, bearing in mind lots of data...
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Obliczanie przesunięć osi toru przy modernizacji łuków parabolicznych na liniach kolejowych
PublicationPodstawowym zadaniem modernizacji linii kolejowych jest właściwe zaprojektowanie nowego układu geometrycznego, który będzie spełniał założone kryteria związane z parametrami eksploatacyjnymi danej linii. Dążąc do spełnienia przyjętych warunków nałożonych na projektowany układ, projektant najczęściej koryguje podstawowe parametry geometryczne, tj. przechyłkę, promień łuku kołowego oraz długości krzywych przejściowych. W artykule...
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Two highly thermostable paralogous single-stranded DNA-binding proteins from Thermoanaerobacter tengcongensis
PublicationThe thermophilic bacterium Thermoanaerobacter tengcongensis has two single-stranded DNA-binding (SSB) proteins, designated TteSSB2 and TteSSB3. In a SSB complementation assay in Escherichia coli, only TteSSB3 took over the in vivo function of EcoSSB. We have cloned the ssb genes obtained by PCR and have developed E. coli overexpression systems. The TteSSB2 and TteSSB3 consist of 153 and 150 amino acids with a calculated molecular...
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Identification and properties of the psychrophilic bacterium Desulfolatea psychrophila single-stranded DNA binding proteins
PublicationTo study the biochemical properties of SSB from Desulfolatea psychrophila (DpsSSB), we have cloned the ssb genes obtained by PCR and have developed Escherichia coli overexpression systems. The gene consists of an open reading frame of 426 nucleotides encoding SSB protein of 142 amino acids with a calculated molecular mass of 15.6 kDa and it is the smallest known bacterial SSB protein indentified to date. The amino-acid sequence...
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Expedited Geometry Scaling of Compact Microwave Passives by Means of Inverse Surrogate Modeling
PublicationIn this paper, the problem of geometry scaling of compact microwave structures is investigated. As opposed to conventional structures (i.e., constructed using uniform transmission lines), re-design of miniaturized circuits (e.g., implemented with artificial transmission lines, ATSs) for different operating frequencies is far from being straightforward due to considerable cross-couplings between the circuit components. Here, we...