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Search results for: EXHALED BREATH CONDENSATES (EBC)
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Development of Sulfamoylated 4‑(1-Phenyl‑1H‑1,2,3-triazol-4-yl)phenol Derivatives as Potent Steroid Sulfatase Inhibitors for Efficient Treatment of Breast Cancer
PublicationWe present here the advances achieved in the development of new sulfamoylated 4-(1-phenyl-1H-1,2,3-triazol-4-yl)phenol derivatives as potent steroid sulfatase (STS) inhibitors for the treatment of breast cancer. Prompted by promising biological results and in silico analysis, the initial series of similar compounds were extended, appending a variety of m-substituents at the outer phenyl ring. The inhibition profiles of the newly...
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Successive cytotoxicity control by evolutionary surface decorated electronic push-pull green ZnCr-LDH nanostructures: Drug delivery enlargement for targeted breast cancer chemotherapy
PublicationThe reason for the increasing bioavailability and biocompatibility of the porous nanomaterials in the presence of different (bio)molecules is still unknown. The role of difference functional groups and their interactions with the potential bioavailability and biocompatibility is of great importance. To investigate the potential contribution of the electronic effects (especially on the surface of the porous nanomaterials) on their...
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A new dilution-enrichment sample preparation strategy for expanded metabolome monitoring of human breast milk that overcomes the simultaneous presence of low- and high-abundance lipid species
PublicationThe complex nature of human breast milk (HBM) makes samples difficult to analyze, requiring several extraction techniques and analytical platforms to obtain high metabolome coverage. In this work, we combined liquid-liquid extraction (LLE) and solid-phase extraction (SPE) techniques to prepare HBM samples to overcome the challenge of low- and high-abundance lipid species, enabling the semiquantitative analysis of total HBM lipids...
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The muscovian letters of Francesco Locatelli (1735), or the illusory modernisation of Russia's legal and political system during the reign of Peter The Great and his successors
PublicationIn the 18 th century thinkers of the French Enlightenment discover Russia, whose institutional reforms replace their traditional utopian topies. The myths of Peter the Great and of Catherine II as Minerva of the North are created Russia also becomes a peculiar laboratory of Enlightenment incarnate. Francesco Locatelli, the author of the Muscovian Letters, who between 1733 and 1735 spend two years in Russian prisons, attempts...
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Modeling and Accuracy Assessment of Determining the Coastline Course Using Geodetic, Photogrammetric and Satellite Measurement Methods: Case Study in Gdynia Beach in Poland
PublicationThe coastal environment represents a resource from both a natural and economic point of view, but it is subject to continuous transformations due to climate change, human activities, and natural risks. Remote sensing techniques have enormous potential in monitoring coastal areas. However, one of the main tasks is accurately identifying the boundary between waterbodies such as oceans, seas, lakes or rivers, and the land surface....
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Oxidative modification induced by photodynamic therapy with Photofrin®II and 2-methoxyestradiol in human ovarian clear carcinoma (OvBH-1) and human breast adenocarcinoma (MCF-7) cells
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In Vitro and In Vivo Imaging-Based Evaluation of Doxorubicin Anticancer Treatment in Combination with the Herbal Medicine Black Cohosh
PublicationAs a substitution for hormone replacement therapy, many breast cancer patients use black cohosh (BC) extracts in combination with doxorubicin (DOX)-based chemotherapy. In this study, we evaluated the viability and survival of BC- and DOX-treated MCF-7 cells. A preclinical model of MCF-7 xenografts was used to determine the influence of BC and DOX administration on tumor growth and metabolism. The number of apoptotic cells after...
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Rozważania na temat bezpiecznego wymiarowania ścinania ze zmiennym kątem THETA w kratownicach zastępczych według norm EC:2003 DIN:2001 PN:2002
PublicationW pracy przedstawiono problem bezpiecznego projektowania elementów żelbetowych na ścinanie według zmodyfikowanego modelu kratownicowego Morscha, w ujęciu normy europejskiej, polskiej i niemieckiej. Wykazano, że przyjmowane graniczne kąty nachylenia betonowych krzyżulców ściskanych mogą być w pełni bezpiecznie stosowane do analizy konstrukcji.
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Improved cytotoxicity and preserved level of cell death induced in colon cancer cells by doxorubicin after its conjugation with iron-oxide magnetic nanoparticles
PublicationA promising strategy for overcoming the problem of limited efficacy in antitumor drug delivery and in drug release is the use of a nanoparticle-conjugated drug. Doxorubicin (Dox) anticancer chemotherapeutics has been widely studied in this respect, because of severe cardiotoxic side effects. Here, we investigated the cytotoxic effects, the uptake process, the changes in cell cycle progression and the cell death processes in the...
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Ceragenin CSA-13 as free molecules and attached to magnetic nanoparticle surfaces induce caspase-dependent apoptosis in human breast cancer cells via disruption of cell oxidative balance
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Differential Response of MDA-MB-231 and MCF-7 Breast Cancer Cells to In Vitro Inhibition with CTLA-4 and PD-1 through Cancer-Immune Cells Modified Interactions
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Aberration of the enzymatic activity of Fhit tumor suppressor protein enhances cancer cell death upon photodynamic therapy similarly to that driven by wild-type Fhit
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Method-Dependent Epidemiological Cutoff Values for Detection of Triazole Resistance in Candida and Aspergillus Species for the Sensititre YeastOne Colorimetric Broth and Etest Agar Diffusion Methods
PublicationAlthough the Sensititre Yeast-One (SYO) and Etest methods are widely utilized, interpretive criteria are not available for triazole susceptibility testing of Candida or Aspergillus species. We collected fluconazole, itraconazole, posaconazole, and voriconazole SYO and Etest MICs from 39 laboratories representing all continents for (method/agent-dependent) 11,171 Candida albicans, 215 C. dubliniensis, 4,418 C. glabrata species complex,...
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Influence of several biodegradable components added to pure and nanosilver-doped PMMA bone cements on its biological and mechanical properties
PublicationAcrylic bone cements (BC) are wildly used in medicine. Despite favorable mechanical properties, processability and inject capability, BC lack bioactivity. To overcome this, we investigated the effects of selected biodegradable additives to create a partially-degradable BC and also we evaluated its combination with nanosilver (AgNp). We hypothesized that using above strategies it would be possible to obtain bioactive BC. The Cemex...
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Mercury concentration and the absolute and relative sizes of the internal organs in cormorants Phalacrocorax carbo (L. 1758) from the breeding colony by the Vistula Lagoon (Poland)
PublicationThis work analyses the effect of mercury on the condition of cormorants (Phalacrocorax carbo) from an extensive breeding colony in northern Poland, the largest in Europe. A total of 55 birds (44 adults and 11 immature) were obtained. Total mercury (Hg) concentrations were measured in the liver, kidneys, breast muscles, heart, gullet (oesophagus), stomach, intestines, trachea, lungs and eyeballs. The total body mass (TBM) and empty...
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The content of conjugated linoleic acid and vaccenic acid in the breast milk of women from Gdansk and the surrounding district, as well as in, infant formulas and follow-up formulas. Nutritional recommendation for nursing women
PublicationFatty acids are some of the most important components of human milk. Polyunsaturated fatty acids (PUFAs) are essential nutrients required for the optimal growth and development of infants, especially the central nervous system, brain and retina. AIM: To determine the conjugated linolenic acid (CLA) and vaccenic acid (VA) content of human breast milk from mothers consuming different diets, and to compare the results with CLA and...
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Mass transfer in the bath reactor of the adsorption process of 1,2-dichloropropane from aqueous solution onto the activated carbon
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Validation of EORTC, CUETO, and EAU risk stratification in prediction of recurrence, progression, and death of patients with initially non–muscle‐invasive bladder cancer (NMIBC): A cohort analysis
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Plaża i Park Nadmorski jako szczególny przypadek kreacji przestrzeni publicznej miasta = The beach and Seaside Park as a special case of city's public space creation
PublicationPrzedmiotem rozważań jest plaża miejska i tereny przyległego Parku Nadmorskiego w Sopocie jako szczególny przypadek kreacji przestrzeni wspólnej.
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Copper(i) complexes with phosphine derived from sparfloxacin. Part III: multifaceted cell death and preliminary study of liposomal formulation of selected copper(i) complexes
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The Influence of Cold Atmospheric Pressure Plasma-Treated Media on the Cell Viability, Motility, and Induction of Apoptosis in Human Non-Metastatic (MCF7) and Metastatic (MDA-MB-231) Breast Cancer Cell Lines
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High-density polyethylene/EPDM rubber blend composites of boron compounds for neutron shielding application
PublicationNovel materials with neutron shielding property were fabricated by incorporating boron compounds into highdensity polyethylene (HDPE)/Ethylene propylene diene monomer rubber (EPDM) blends. A detailed investigation on the morphological, thermal, mechanical, and neutron attenuation properties of suitable proportion of HDPE/EPDM blend with boric acid (BA), boron carbide (BC), and nano boron carbide (NBC) were performed. Morphology...
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Long Distance Vital Signs Monitoring with Person Identification for Smart Home Solutions
PublicationAbstract— Imaging photoplethysmography has already been proved to be successful in short distance (below 1m). However, most of the real-life use cases of measuring vital signs require the system to work at longer distances, to be both more reliable and convenient for the user. The possible scenarios that system designers must have in mind include monitoring of the vital signs of residents in nursing homes, disabled people, who...
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Auto adaptation of mobile device characteristics to various acoustic conditions
PublicationThe proposed methodology of auto adaptation of the mobile device characteristics to various acoustic conditions is presented in the paper. The first goal of this study was to determine the parameters of the acoustic path of the mobile device, for both transmitting (speaker) and receiver (microphone). Results of the measurement of characteristics of mobile devices were presented. Information about characteristics of individual parts...
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Music signal equalization in a changing environment
PublicationThe paper presents the concept of an automatic system for music signal correction, considering room frequency response and music genre being played. The proposed algorithm, based on the room frequency response, compensates acoustic conditions surrounding the sound source. Additionally, the compensation process considers the signal content by recognizing music genre. As part of the described research, a series of subjective tests...
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Thermodynamic analysis of the double Brayton cycle with the use of oxy combustion and capture of CO2
PublicationIn this paper, thermodynamic analysis of a proposed innovative double Brayton cycle with the use of oxy combustion and capture of CO2, is presented. For that purpose, the computation flow mechanics (CFM) approach has been developed. The double Brayton cycle (DBC) consists of primary Brayton and secondary inverse Brayton cycle. Inversion means that the role of the compressor and the gas turbine is changed and firstly we have expansion...
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3D modelling of beach topography changes caused by the tombolo phenomenon using terrestrial laser scanning (TLS) and unmanned aerial vehicle (UAV) photogrammetry on the example of the city of Sopot
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Detection of gaseous compounds with different techniques
PublicationSensing technology has been developed for detection of gases in some environmental, industrial, medical, and scientific applications. The main tasks of these works is to enhance performance of gas sensors taking into account their different applicability and scenarios of operation. This paper presents the descriptions, comparison and recent progress in some existing gas sensing technologies. Detailed introduction to optical sensing...
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Measuring the effectiveness of digital communication - social media performance: an example of the role played by AI-assisted tools at a university
PublicationThe aim of the article is to show the role played by AI-powered tools in measuring the effectiveness of digital communication in social media using a university case study. Therefore, a research problem was formulated to identify the metrics (KPIs) used to measure the effectiveness – non-financial outcomes – of digital social media communication at the university using AI tools. The literature review on the role of AI in digital...
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Validation of EORTC, CUETO and EAU risk stratification in prediction of recurrence, progression and death of patients with initially non-muscle invasive bladder cancer (NMIBC): a cohort analysis with systematic review.
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Theory versus experiment for vacuum Rabi oscillations in lossy cavities. II. Direct test of uniqueness of vacuum
PublicationThe paper continues the analysis of vacuum Rabi oscillations we started in part I [Phys. Rev. A 79, 033836 (2009)]. Here we concentrate on experimental consequences for cavity QED of two different classes of representations of harmonic-oscillator Lie algebras. The zero-temperature master equation, derived in part I for irreducible representations of the algebra, is reformulated in a reducible representation that models electromagnetic...
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Estimation of the effectiveness of nbpt for limiting ammonia emission from urea based on the field experiments
PublicationThe efectiveness of the ammonia emission reduction from NBPT-stabilized urea was investigating in 2011 during a field experiment on a grassland plot fertilized with a one-time dose of 60 kgN/ha. The obtained reduction coefficient of ammonia emission equaled 73% and 39-51% relative to erea without the inhibitor and ammonium nitrate, respectively.
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Elevated Levels of Renalase, the β-NAD(P)H Isomerase, Can Be Used as Risk Factors of Major Adverse Cardiovascular Events and All-Cause Death in Patients with Chronic Kidney Disease
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Association between plasma proteome profiles analysed by mass spectrometry, a lymphocyte-based DNA-break repair assay and radiotherapy-induced acute mucosal reaction in head and neck cancer patients
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Altruism, egoism, and the wealthy. Review of a book: Beth Breeze (2021). In defence of philanthropy. Newcastle upon Tyne: Agenda Publishing (pp. 181)
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Experimental research on marine oil-lubricated stern tube bearing
PublicationBearings of propeller shafts are very crucial elements of the propulsion system of each of the ships. The safety of shipping depends on their durability and reliability. The new legal restrictions mean that today we are looking for environmentally friendly solutions. That is why water-lubricated bearings are becoming more and more popular. So, will oil-lubricated shaft bearings belong to the past? The bearing with a white metal...
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Analysis of unsteady flow forces on the thermowell of steam temperature sensor
PublicationIn this paper, 3D numerical analysis of unsteady flow forces acting on the measuring sheath of steam temperature is presented. According to that purpose, the CFD (Computation Fluid Dynamic [1]) approach has been used. The nonstationary of fluid acting on the measuring sheath such as: Strouhal frequency, amplitude of pressure, structure of vortex, peak of pressure, field of pressure, field of velocity etc. are studied analytically...
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Skład i zawartość kwasów tłuszczowych w mleku kobiet z gdańska i okolic w różnych okresach laktacji = Fatty acid composition in breast milk of women from gdańsk and the surrounding district in the course of lactation
PublicationCelem pracy była ocena składu i zawartości kwasów tłuszczowych w tłuszczu mleka kobiet w różnych okresach laktacji, z uwzględnieniem składu KT pokarmu spożywanego przez matki. Do badań zakwalifikowano 80 położnic od których uzyskano próbki mleka w 2, 14, 30 i 90 dobie laktacji. Jednocześnie przeprowadzono badania ankietowe na podstawie których oszacowano zawartość poszczególny grup KT w dziennej racji pokarmowej matek. Skład i...
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„Eulerian – Eulerian” versus ,,Eulerian –Lagrangean” models of condensation
PublicationLiquid phase in the flowing vapor through stages of the steam turbine is the cause of a lot of failures. Nowadays, due to work of steam turbines at partial load, process of homogeneous and heterogeneous condensation still is current. The formation of drops of condensate under conditions other than nominal operation of turbine is a process still unknown. Engineers and designers involved in the development of power station machines...
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Assessment of cytotoxic and endocrine potential of selected xenobiotics commonly present in food products
PublicationMore and more increased intensity of anthropopressure processes can be observed, among other things, in the release of great quantities of synthetic substances into the environment, including the Endocrine Disrupting Compounds (EDC). A vast number of chemical substances is considered to belong to the this group, including substances which occur naturally in the environment, such as mycotoxins and phytoestrogens, and substances...
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Machine-aided detection of SARS-CoV-2 from complete blood count
PublicationThe current gold standard for SARS-CoV-2 detection methods lacks the functionality to perform population screening. Complete blood count (CBC) tests are a cost-effective way to reach a wide range of people – e.g. according to the data of the Central Statistical Office of Poland from 2016, there are 3,000 blood diagnostic laboratories in Poland, and 46% of Polish people have at least one CBC test per year. In our work, we show...
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Web component for automatic extraction of ontological information from informal description of web services
PublicationThis article treats about usage possibilities of Web Services and cooperation in development that leads to constant improvement of these components. It describes the semantic methods which can beused to create the description that is comprehensible for computers. It also presents the two models supporting the automatic generation of the semantic description based on informal description. Thepaper draws upon the comparison of two...
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The exploitation of anticarcinogenic potential of white cabbage to improve nutritional value of meat products
PublicationBadania dotyczyły wykorzystania zalet składników kapusty białej w celu opracowania technologii wytwarzania wyrobów mięsnych wzbogaconych w związki przeciwrakotwórcze a zatem o poprawionej wartości żywieniowej. Wybór warzywa wynikał zarówno z środkowoeuropejskiej tradycji spożywania kapusty z daniami mięsnymi jak i badań modelowych wskazujących na technologiczne i zdrowotne zalety skojarzenia tego warzywa z mięsem.
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The effect of cabbage juices on the activity and expression of GST isozymes in HepG2 cells
PublicationWcześniejsze badania pokazały zdolność soków z kapusty białej do indukowania aktywności enzymów detoksykacyjnych. Prezentowane wyniki potwierdziły zdolność fitokompleksu kapusty do stymulacji aktywności enzymów z grupy GST w komórkach HepG2 - modelu ludzkiej wątroby - w szczególności izoenzymów GST-alfa i GST-mi.
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Imidazoacridinone derivative C-1311 (SymadexTM) induces apoptosis, mitotic catastrophe or senescence in human colon carcinoma HCT116 cells depending on p53 status
PublicationPrzeprowadziliśmy badania zmierzające do wyjaśnienia odpowiedzi komórek ludzkiego raka jelita grubego HCT116 traktowanych C-1311 w zależności od statusu białka p53. Wykazaliśmy, że pochodna imidazoakrydonu C-1311 w stężeniach biologicznie istotnych indukuje przejściowy blok w fazie G2M komórek HCT116 p53-/- oraz blok w fazie G1 i G2M komórek HCT116 p53+/+. W komórkach z niefunkcjonalnym białkiem p53 imidazoakrydon indukował katastrofę...
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Enhanced Toxicity of Bisphenols Together with UV Filters in Water: Identification of Synergy and Antagonism in Three-Component Mixtures
PublicationContaminants of emerging concern (CEC) localize in the biome in variable combinations of complex mixtures that are often environmentally persistent, bioaccumulate and biomagnify, prompting a need for extensive monitoring. Many cosmetics include UV filters that are listed as CECs, such as benzophenone derivatives (oxybenzone, OXYB), cinnamates (2-ethylhexyl 4-methoxycinnamate, EMC) and camphor derivatives (4-methylbenzylidene-camphor,...
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Recycled rubber wastes-based polymer composites with flame retardancy and electrical conductivity: Rational design, modeling and optimization
PublicationPolymer recycling techniques experience a maturity period of design and application. Rubbers comprise a high proportion of polymer wastes, highly flammable and impossible to re-melt. Polymer composites based on ground tire rubber (GTR) and ethylene-vinyl acetate copolymer (EVA) containing carbon black (CB) (1–50 phr), with variable EVA/GTR weight composition (10/90, 25/75, 50/50, 75/25 and 90/10), and processing temperature (Low:...
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Nanosilver-loaded PMMA bone cement doped with different bioactive glasses – evaluation of cytocompatibility, antibacterial activity, and mechanical properties
PublicationNanosilver-loaded PMMA bone cement (BC-AgNp) is a novel cement developed as a replacement for conventional cements. Despite favorable properties and antibacterial activity, BC-AgNp still lacks biodegradability and bioactivity. Hence, we investigated the doping with bioactive glasses (BGs) to create a new bioactive BC characterized by time-varying porosity and gradual release of nanosilver. The BC Cemex was used as the base material...
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3D Model Preparing Patterns for Interactive Urban Visualization - Guidelines for Graphic Designers Preparing 3D Models for Virtual Reality Applications
PublicationWhile working on architectural visualizations, the software developer often has to work with graphic designers who create models in a different environment what can cause many complications. For this reason, it is very important to have some guidelines which can protect both the developer and the designer from commixing mistakes. The paper presents a list of such guidelines based on the authors’ experience. The reader can treat...
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Potencjał kognitywno-kulturowy dzielnicy a innowacyjne strategie rehabilitacji w kontekście społecznej indywidualizacji. Studium przypadku: Mouraria, Lizbona = Innovative Public Space Rehabilitation Models to Create Cognitive-Cultural Urban Economy in the Age of Mass Individualisation. Case of Mouraria, Lisbon
PublicationInnovative Public Space Rehabilitation Models to Create Cognitive- -Cultural Urban Economy in the Age of Mass Individualisation. Case of Mouraria, Lisbon. This paper deals with the issue of sustainable urban rehabilitation interventions in city cores focused on value creation through culture-led development as a tool for building a cognitive city. The objective is to analyze cases of rehabilitation of public space by culture-led...