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Search results for: ims
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H2AX phosphorylation, its role in DNA damage response and cancer therapy
PublicationDouble-strand breaks (DSBs) are the most deleterious DNA lesions, which, if left unrepaired, may have severe consequences for cell survival, as they lead to chromosome aberrations, genomic instability, or cell death. Various physical, chemical, and biological factors are involved in DSB induction. Cells respond to DNA damage by activating the so-called DNA damage response (DDR), a complex molecular mechanism developed to detect...
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On the dervative of the Legendre function of the first kind with respect to its degree [Corrigendum]
PublicationSkorygowano błąd matematyczny w pracy: R. Szmytkowski, On the derivative of the Legendre function of the first kind with respect to its degree, J. Phys. A: Math. Gen. Vol. 39(2006) s. 15147-15172 [744014]
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Cellular senescence induced by DNA damage and its role in carcinogenesis and chemotherapy
PublicationUszkodzenia DNA indukują w komórce różne procesy, w tym starzenie komórkowe, co może uruchamiać proces karcinogenezy jak i być związane z odpowiedzią na leki przecinowotworowe. Biologiczna rola starzenia komórkowego nie jest jednak jasna. Zasugerowano, że proces starzenia komórkowego może hamować proces karcinogenezy poprzez indukcję nieodwracalnego zahamowania wzrostu przez czynniki genotoksyczne. Indukcja starzenia komórkowego...
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Addendum to ''On the derivative of the Legendre function of the first kind with respect to its degree''
PublicationPraca stanowi uzupełnienie wcześniejszej publikacji autora [J. Phys. A: Math. Gen. 39(2006) 15147-15172]. Przedstawiono w niej nowe wyrażenia dla pochodnej funkcji Legendre'a względem jej indeksu i zastosowano je do konstrukcji dwóch nowych reprezentacji funkcji Legendre'a drugiego rodzaju z całkowitym indeksem.
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MLPG Method using kd-trees and its application to Flamant Problem
PublicationW pracy przedstawiono rozwiązanie problemu Flamanta z zastosowaniem metody bezsiatkowej MLPG. Oryginalnym pomysłem była aplikacja algorytmu kd-drzew do poszukiwania najbliższych punktów interpolacji dla funkcji radialnych.
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Existence and uniqueness for neutral equations with delay dependant on a solution and its derivative
PublicationDla wykazania istnienia i jednoznaczności w pracy została zaprezentowana metoda porównawcza.
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Stress analysis in the steel tank shell at its connection with product pipeline
PublicationPrzeanalizowano zaburzenia stanu błonowego w powłoce zbiornika walcowego pionowego w strefie przyłączenia do płaszcza rurociągu produktowego
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Combretastatin A-4 (CA-4) and its analogues. Synthesis and biological activity
PublicationSpośród wielu związków przeciwnowotworowych otrzymanych w ostatnich dwóch dekadach, na szczególną uwagę zasługują te, które powodują reorganizację mikrotubul. Jedną z takich substancji jest opisana w artykule kombretastatyna A-4 (CA-4), związek który indukuje apoptozęproliferujących komórek śródbłonka naczyń guza nowotworowego. Hamuje on polimeryzację tubuliny, prowadząc do rozpadu mikrotubul. CA-4 wyizolowana została z kory wierzby...
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Palladium nanoparticles deposited on graphene and its electrochemical performance for glucose sensing
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Snow cover and its variability in the Polish Sudetes Mts. and the Sudetic Foreland
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Modelling of Thyroid Peroxidase Reveals Insights into Its Enzyme Function and Autoantigenicity
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Artemisia dracunculus (Tarragon): A Review of Its Traditional Uses, Phytochemistry and Pharmacology
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Recent Trends in the Application of Chromatographic Techniques in the Analysis of Luteolin and Its Derivatives
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25(OH)D3 in patients with ovarian cancer and its correlation with survival
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A Modeling Problem of a Continuous-Time Domain Signal and Its Discrete Counterpart
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Concept of 'Good Urban Governance' and Its Application in Sustainable Urban Planning
PublicationContemporary urban theory and practice in the post-industrial era is increasingly often turning towards an approach based on sustainable development. That concept bearing the traits of a paradigm has grown on the ground of broad quest for an alternative to the existing development model of the industrial civilisation. It has gained wide social acceptance and is the basis for many development and environmental programmes at the...
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Next generation ITS implementation aspects in 5G wireless communication network
PublicationIn the paper the study of Intelligent Transportation systems implementation in the 5G wireless communication network is presented. Firstly, small-cell concept in Ultra Dense Heterogeneous network was analyzed. Secondly, the 5G network requirements were presented which are important from the point of view of transportation systems development. Next, the study on the 5G network architectures proposals dedicated to the ITS systems...
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Wdrażanie systemów ITS na przykładzie miasta Łodzi i Bydgoszczy
PublicationW niniejszym artykule opisano zalety funkcjonowania, przyczyny wdrażania i wskazano ścieżkę rozwoju Inteligentnych Systemów Transportowych w miastach. Przedstawiono krótką analizę podstaw prawnych wdrażania systemów ITS. Opisano dwa praktyczne przykłady wdrażania systemów ITS w Polsce, na przykładzie wdrożenia zintegrowanego systemu zarządzania ruchem w mieście Łodzi i mieście Bydgoszczy. Cechą charakterystyczną obu projektów był...
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Structural Health Monitoring of Composite Shell Footbridge for Its Design Validation
PublicationThe paper presents the structural health monitoring system of the composite bridge for pedestrians and cyclists. The footbridge was designed and manufactured within the FOBRIDGE project. It is the first bridge in the world, which is classified as a consistent single element structural girder, made of sandwich shells, entirely produced in a single cycle. The developed structural health monitoring system, supported design process,...
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Multi-level Virtualization and Its Impact on System Performance in Cloud Computing
PublicationThe results of benchmarking tests of multi-level virtualized environments are presented. There is analysed the performance impact of hardware virtualization, container-type isolation and programming level abstraction. The comparison is made on the basis of a proposed score metric that allows you to compare different aspects of performance. There is general performance (CPU and memory), networking, disk operations and application-like...
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The Effect of Circular Saw Blade Clamping Diameter on its Resonant Frequencies
PublicationIn this paper results of comparison of characteristic resonant frequencies of circular saw blades as a function of the saw clamping diameter from the impact test are presented. Obtained results revealed that proportionally with the increase of the saw clamping diameter also the dynamical stiffness of the saw blade increased. As a consequence of that the resonant frequencies of the saw blade move to higher values. Moreover, with...
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The effect of circular saw blade clamping diameter on its resonant frequencies
PublicationIn this paper results of comparison of characteristic resonant frequencies of circular saw blades as a function of saw clamping diameter from the impact test are presented. Obtained results revealed that proportionally with the increase of the saw clamping diameter also the dynamical stiffness of the saw blade increased. As a consequence of that the resonant frequencies of the saw blade move to higher values. Moreover, with the...
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Thermal ablation modeling via the bioheat equation and its numerical treatment
PublicationThe phenomenon of thermal ablation is described by Pennes’ bioheat equation. This model is based on Newton’s law of cooling. Many approximate methods have been considered because of the importance of this issue. We propose an implicit numerical scheme which has better stability properties than other approaches.
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Histaminol and Its Complexes with Copper(II) - Studies in Solid State and Solution
PublicationHistaminol [4(5)-(B-hydroxyethyl)imidazole, 4-(1H-imidazol-2-yl)ethanol, L] is an analogue of histamine and its minor metabolite. So far its properties have not been studied in detail due to the synthetic difficulties. Here, the structure and acid-base properties of histaminol, as well as the results of studies on its copper(II) complexes in solid state and aqueous solution are reported. Stability constants of the histaminol–CuII...
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Sources of Market Information, Its Quality and New Product Financial Performance
PublicationWhile we observe a growing interest in the role of market information in new product development (NPD), existing research has still largely ignored the quality of market information that is a crucial issue in the era of the information society. What does affect the quality of market information in new product development projects, and how does this quality influence the financial performance of new products? In this paper, we address...
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Pantographic metamaterials: an example of mathematically driven design and of its technological challenges
PublicationIn this paper, we account for the research efforts that have been started, for some among us, already since 2003, and aimed to the design of a class of exotic architectured, optimized (meta) materials. At the first stage of these efforts, as it often happens, the research was based on the results of mathematical investigations. The problem to be solved was stated as follows: determine the material (micro)structure governed by those...
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THE ART OF VIRTUAL INFORMATION EXCHANGE AND ITS INFLUENCE ON REAL CITY SPACE
PublicationThe paper investigates the impact of the new genres of contemporary public art based on the virtual information exchange in real spaces of the cities. On the basis of theoretical approaches, trans-disciplinary surveys and case studies, the paper focuses on the art that not only relies on the technological support but also refers to the new public sphere, where people are co-creators of the art object giving their personal input...
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THE PANTOGRAPH AND ITS GEOMETRIC TRANSFORMATIONS - A FORMER POPULAR TOOL FOR COPYING AND SCALING
PublicationDevelopment of digital technology has resulted in significant transformations of designer workshops. Computer applications replaced the previously existing tools and methods for drawing up of projects. Professional, sophisticated drawing instruments and tools for manual plotting, as well as basic drawing aids, have gradually fallen into oblivion and become relicts of a bygone era - the objects of collectors' interest. Gdansk University...
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Stability analysis of a road scarp in the Carpathian Mountains and methods of its protection
PublicationThe purpose of the study was to analyse the stability of a road scarp endangered by a landslide and to consider some measures for its stabilization. The potential landslide could unfavourably alter the shape of the slope, thus a religious sanctuary situated above the slope. The present research has resulted in suggestions of possible protection methods, namely, drainage, soil nailing, installation of piles, supporting the scarp...
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The influence of position of the post or its absence on the performance of the cable barrier system
PublicationRoad safety barriers are used to increase safety in potentially dangerous places on the roads. They are designed and installed on the roads to prevent any vehicle from getting outside the travelled way or from entering the opposite lane of the road. Barriers, which are used on European roads, have to undergo full scale crash tests according to the EN 1317 standards. Nowadays as a supplement to real crash tests, numerical simulations...
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Realizacja elementu LMS wspomagającego proces oceny wiedzy uczestników kursu
PublicationW rozdziale monografii omówiono mechanizmy realizacji testowania wiedzy studentów w systemach LMS. Przedstawiono opracowany na Wydziale Elektroniki, Telekomunikacji i Informatyki Politechniki Gdańskiej element systemu LMS oceny wiedzy uczestników zajęć laboratoryjnych. Wyróżniającą cechą tego systemu jest jego modułowa, rozproszona i hierarchiczna architektura oraz niezależność od jakości pracy sieci komputerowej.
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The conditions of the business services sector in Poland and its competitiveness in the global market
PublicationThe following article presents the conditions of the business services sector (BSS) in Poland and the assessment of its competitiveness in the global market. The first section discusses the BSS sector and the categories of the provided services, in the division of business process outsourcing, shared services center, information technology outsourcing, research and development. Next the authors presents the status of the business...
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Investigation of energy deposition and its optical imaging in polymer gel dosimeters
PublicationThis following chapter describes methods for verifying the absorbed dose during radiotherapy. Special attention is paid to the method using polymer-gel dosimeters, the dose reading of which is performed by means of Laser Computed Tomography. The chapter also includes considerations on alternative solutions for dosimetric measurements and various types of radiotherapy and their pros and cons. In addition, both the methods of structural...
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Checkpoints that regulate balanced biosynthesis of lipopolysaccharide and its essentiality in Escherichia coli
PublicationThe outer membrane (OM) of Gram-negative bacteria, such as Escherichia coli, is essential for their viability. Lipopolysaccharide (LPS) constitutes the major component of OM, providing the permeability barrier, and a tight balance exists between LPS and phospholipids amounts as both of these essential components use a common metabolic precursor. Hence, checkpoints are in place, right from the regulation of the first committed step...
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QRS Morphology-Based EDR Signal—Factors Determining its Properties
PublicationRespiration-induced signals contain a clinically significant information. It could be obtained utilizing both direct and indirect methods. ECG-Derived Respiration (EDR) method is the latter one. However, in this case, two approaches could be distinguished. First one is based on determining changes in the morphology of QRS complexes while the second one is based on the Respiratory Sinus Arrhythmia (RSA) mechanism. The former approach...
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RMS-based damage detection in reinforced concrete beams: numerical simulations
PublicationImage-based damage detection methods using guided waves are well known and widely applied approaches in structural diagnostics. They are usually utilized in detection of surface damages or defects of plate-like structures. The article presents results of the study of applicability of imaging wave-based methods in detection in miniscule internal damage in the form of debonding. The investigations were carried out on numerical models...
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Effects of the Origin and Deacetylation Degree of Chitosan on Properties of Its Coatings on Titanium
PublicationThe properties of chitosan coatings on titanium surfaces may be influenced by a variety of factors, including their chemical characteristics and the deposition method. The aim of this research was to determine the influence of a chitosan’s origin (a type of shrimp) and deacetylation degree (DD), when deposited on a very smooth titanium surface, on adhesion and biological behavior. The tests were performed using chitosan of a degree...
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Identification of the Agile Mindset and Its Comparison to the Competencies of Selected Agile Roles
PublicationIn this paper we present the results of the identification and evalua-tion of the elements of an agile mindset as well as its comparison to the compe-tence models for the roles of Scrum Master, Product Owner and agile analyst. We have identified 70 unique agile mindset elements from literature and 5 in-terviews with experts. Based on an opinion survey among 52 agile practitioners we evaluated the importance of 26 selected elements...
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Representing and Managing Experiential Knowledge with Decisional DNA and its Drimos® Extension
PublicationThe Semantic Web concept is proposing a future concept of the WorldWideWeb (WWW) where both humans and man-made systems are able to interconnect and exchange knowledge. One of the challenges of Semantic Web is smart and trusted accommodation of knowledge in artificial systems so it can be unified, enhanced, reused, shared, communicated and distributed with added aptitude. Our research represents an important component of addressing...
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Preparatory Railway Track Geometry Estimation Based on GNSS and IMU Systems
PublicationThe article discusses an important issue of railway line construction and maintenance, which fundamentally is the verification of geometric parameters of the railway track. For this purpose, mobile measurements have been performed using a measuring platform with two properly arranged GNSS receivers, which made it possible to determine the base vector of the platform. The measuring functionality of the system was extended by IMU....
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“Project-factor-decision”. Decisive factors in IT projects and their impact on its success
PublicationThe aim of this article is to indicate the need for a deepening, systematizing and codifying of the theoretical and practical knowledge on IT project management, in the area of management decision-making processes. The scope of decisions made by managers is constantly on the increase. Project managers make decisions not only within the classic triangle of constraints, which consists of a schedule, a budget and the project scope,...
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PROBLEM RUCHU SMS A2P - JEGO ANALIZA I SPOSOBY ROZWIĄZANIA
PublicationRuch SMSowy typu A2P (Application to Person) jest dla operatorów źródłem problemów, które objawiają się dla jednych w postaci strat, a dla innych nieuprawnionymi zyskami. W artykule omówiono ten problem od strony technicznej, tzn. gdzie leży jego przyczyna i jak można przeciwdziałać temu zjawisku i mieć jednocześnie z tego tytułu korzyści.
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An asymmetrical λ-foot of condensing steam flow in the IMP PAN nozzle
PublicationIn the present paper we have focused on the precise prediction of the spontaneous condensation phenomena in wet steam flow. Novelty of our approach lies on modelling both the moment of initiation of a phase transition, as well as the moment of its reverse progress - called here re-vaporization of the condensate phase. The practical issue is to elaborate of a model of spontaneous condensation/vaporization of water steam flow...
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Continuous-time active-RC filters: general model and its applications.
PublicationW pracy przedstawiono ogólny model filtru aktywnego RC opartego na wzmacniaczach odwracających fazę. Model analizowany jest przy użyciu równań macierzowych. Podano jawną formułę określającą funkcję przenoszenia filtru w ogólnym przypadku. Przedstawiono rozszerzenia modelu pozwalające uwzględniać nieidealności wzmacniaczy operacyjnych, w tym skończone wzmocnienie i pasmo przenoszenia oraz niezerową rezystancję wyjściową. Zastosowanie...
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Relation between steel microstructure and its properties in inert and aggressive environments
PublicationBadano stale 26H2MF i 34HNM poddane różnej obróbce cieplnej. Mikrostruktury stali zmieniały sie od martenzytu i bainitu do odpuszczonego martenzytu i sorbitu. Obserwowano spadek energii zniszczenia, wydłużenia i przewżenia w próbie rozciągania z małą prędkością i równoczesnej polaryzacji katodowej do 100 mA/cm2. Degradacji towarzyszyła zmiana przełomu z ciągliwego na kruchy łupliwy i quasiłupliwy.
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Dopants and gas modifiers in ion mobility spectrometry
PublicationThe ion mobility techniques, including the most commonly used drift-tube ion mobility spectrometry (IMS) and differential mobility spectrometry (DMS), are used successfully for the detection of a wide range of organic compounds in the gas phase. In order to improve detection quality, admixtures are added to gas streams flowing through the detector. Dopants mostly prevent the ionization of interfering chemicals however, better detection...
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Development and validation of GC–MS/MS method useful in diagnosing intestinal dysbiosis
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PTR-MS and GC-MS as complementary techniques for analysis of volatiles: A tutorial review
PublicationThis tutorial review is a critical commentary on the combined use of two instrumental analytical techniques, namely GC-MS and PTR-MS. The first mention of such an analytical approach likely appeared after the year 2000 and despite many advantages, it has not been applied very often. Therefore, the aim of this article is to elaborate on the concept of their combined use and to provide a curse tutorial for those considering taking...
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Recent Applications of 1D GC-MS and 2D GC-MS in Foodomics Studies
PublicationGas chromatography coupled with mass spectrometry and food chemistry have been tightly linked since the 1960s. This setup is also an integral part of the omics studies when it comes to low mass metabolites. Therefore, the marriage of GC-MS and foodomics is obvious. Two-dimensional gas chromatography coupled with mass spectrometry fits perfectly within the latest trends in foodomics, since it is tailored for holistic food analysis....
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Diminshed toxicity of C-1748, 4-methyl-9-hydroxyethylamino-1-nitroacridine, compared with its demethyl analog, C-857, corresponds to its resistance to metabolism in HepG2 cells
PublicationThe narrow "therapeutic window" of anti-tumour therapy may be the result of drug metabolism leading to the activation or detoxification of antitumour agents. The aim of this work is to examine (i) whether the diminished toxicity of a potent antitumour drug, C-1748, 9-(2'-hydroxyethylamino)-4-methyl-1-nitroacridine, compared with its 4-demethyl analogue, C-857, results from the differences between the metabolic pathways for the...