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Wyniki wyszukiwania dla: DECISIONAL DNA, VIRTUAL ENGINEERING FACTORY (VEF), VIRTUAL ENGINEERING OBJECT (VEO), VIRTUAL ENGINEERING PROCESS (VEP)
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Toward Intelligent Recommendations Using the Neural Knowledge DNA
PublikacjaIn this paper we propose a novel recommendation approach using past news click data and the Neural Knowledge DNA (NK-DNA). The Neural Knowledge DNA is a novel knowledge representation method designed to support discovering, storing, reusing, improving, and sharing knowledge among machines and computing systems. We examine our approach for news recommendation tasks on the MIND benchmark dataset. By taking advantages of NK-DNA, deep...
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An insight into the mixed quantum mechanical-molecular dynamics simulation of a ZnII-Curcumin complex with a chosen DNA sequence that supports experimental DNA binding investigations
PublikacjaAn important aspect of research pertaining to Curcumin (HCur) is the need to arrest its degradation in aqueous solution and in biological milieu. This may be achieved through complex formation with metal ions. For this reason, a complex of HCur was prepared with ZnII, that is not likely to be active in redox pathways, minimizing further complications. The complex is monomeric, tetrahedral, with one HCur, an acetate and a molecule...
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Measuring the density of DNA films using ultraviolet-visible interferometry
PublikacjaIn order to determine a proper value for the density of dry DNA films we have used a method based upon the measurement of interference effects in transmission spectra of thin DNA layers. Our results show that the methodology is effective and the density of DNA in this state, 1.407 g/cm3, is much lower than the commonly used 1.7 g/cm3. Obtaining accurate values for the DNA film density will allow the optical constants for DNA to...
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Evaluation of occupational exposure in a slide bearings factory on the basis of urine and blood sample analyses
PublikacjaZbadano wpływ pracy w zakładach łożysk ślizgowych na zdrowie pracowników. Przeprowadzono analizę próbek moczu i krwi pobranych od 42 pracowników i 6 osób zatrudnionych w administracji przedsiębiorstwa, stanowiących grupę kontrolną. Oznaczono zawartość Al, Cu, Pb i Zn we krwi i moczu pracowników dwukrotnie, przed i po terapii za pomocą chelatowania, stosując ICP-MS oraz metodę dodatku wzorca. Istotność różnic w zawartości pierwiastków...
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Machining process sequencing and machine assignment in generative feature-based CAPP for mill-turn parts
PublikacjaProcess selection and sequencing, as one of the most complex issues when evaluated from a mathematical point of view and crucial in CAPP, still attract research attention. For the current trend of intelligent manufacturing, machining features (MFs) are the information carriers for workpiece geometry and topology representation. They are basically derived from CAD models and are used by downstream engineering applications. A feature-based...
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High-temperature heat pumps – potential technology for heat recovery and production of process heat
PublikacjaIn the paper, the high temperature vapour compressor based heat pump with a selection of working fluids, both perspective and ecological ones, is considered. Such system is not yet commercially available on the market and in author’s opinion it has significant potential for various applications. In the presented analysis it was assumed that the heat source has a temperature of 50oC and the temperature lift is 60, 80 and 100K respectively....
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A Semiautomatic Experience-Based Tool for Solving Product Innovation Problem
PublikacjaIn this paper we present the idea of Smart Innovation Engineering (SIE) System and its implementation methodology. The SIE system is semi-automatic system that helps in carrying the process of product innovation. It collects the experiential knowledge from the formal decisional events. This experiential knowledge is collected from the group of similar products having some common functions and features. The SIE system behaves like...
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The effects of vehicle restraint systems on road safety
PublikacjaKey to understanding the needs and tools of road infrastructure management for preventing run-off-road crashes or minimising their consequences, is to identify the hazads and sources of hazards caused by wrong or improper use of road safety devices and identify errors in the desifn, structure, construction and operation of road safety devices. Studying such an extended scope of the problem required fieldwork and surveys with road...
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Analysis of degaussing process of ferromagnetic objects
PublikacjaResults of the analytical and numerical analysis of the degaussing process phenomena of ferromagnetic objects were presented in this paper. The screening effectiveness of the electromagnetic field of magnetic screens in most cases depends on thickness, conductivity, magnetic permeability of the screen and angular frequency of degaussing currents. The magnetic field inside thin-layer ferromagnetic object was presented in this paper....
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Mechanochemically synthesized Mn3O4@β-cyclodextrin mediates efficient electron transfer process for peroxymonosulfate activation
PublikacjaThe rational surface engineering of heterogeneous catalysts is of great significance in advanced oxidation processes (AOPs) for eliminating refractory contaminants but remains challenging. In this study, β-cyclodextrin modified Mn3O4 (Mn3O4@β-CD) was prepared through a mechanochemical approach for peroxymonosulfate (PMS) activation, which achieved efficient bisphenol A (BPA) removal via electron transfer process (ETP). The reactive...
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GIS three-dimensional Modelling with geo-informatics techniques
PublikacjaThe integration issue of virtual models and geo-referenced database have a very broad spectrum of potential applications. Before the integration issue was on the cusp, it was quite problematic to combine three-dimensional models with the geo-referenced database. An integrated database contains a variety of data including such as object orientated data model and raster data. Within this paper, authors present an integration process...
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Testing of Software for the Planning of a Linear Object GNSS Measurement Campaign under Simulated Conditions
PublikacjaThe precision of a linear object measurement using satellite techniques is determined by the number and the relative position of the visible satellites by the receiver. The status of the visible constellation is described by DOP. The obtained geometric coefficient values are dependent on many variables. When determining these values, field obstacles at the receiver location and satellite positions changing with time must be taken...
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Internet photogrammetry as a tool for e-learning
PublikacjaAlong with Internet development, there were interactive applications which allow for remote sensing and photogrammetric analysis. An example of an application that can provide Earth images and make it possible to measure distances in these images is Google Earth. The authors, who have experience from 2001-2015 argue that it is possible and it is important to create more advanced photogrammetric network applications. In this there...
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Termodynamika niekowalencyjnego oddziaływania małocząsteczkowych ligandów z dna
PublikacjaKwasy nukleinowe są jednym z głównych celów biologicznych dla wielu antybiotyków oraz leków przeciwnowotworowych i przeciwwirusowych. Podczas tworzenia nowych farmaceutyków ważna jest dokładna wiedza na temat sposobu wiązania się leku do DNA. Oddziaływanie ligand-DNA można podzielić na dwie grupy: 1. wiązanie kowalencyjne, które często prowadzi do utworzenie trwałych wiązań pomiędzy nićmi DNA, 2. fizykochemiczne wiązanie, które...
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Smart Modeling of Maritime Vessels
PublikacjaCurrently, the market offers many visualization tools available to graphic designers, engineers, managers and academics working on maritime environments. The practice of visualization involves making and manipulating images that convey novel phenomena and ideas. Visual communication, together with virtual reality environments, is an emerging and rapidly evolving discipline. It brings great advantage over written word or voice alone,...
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Metylacja DNA w rozwoju, diagnostyce i terapii nowotworów
PublikacjaDotychczas kowalencyjna modyfikacja DNA, jaką jest zarówno naturalna metylacja DNA, jak i addukty DNA egzogennych niskocząsteczkowych związków chemicznych, były ropatrywane z punktu widzenia genomu. W świetle obecnej wiedzy dotyczącej epigenomu można sądzić, że stosunkowo niewielkie modyfikacje czy to w postaci metylacji cytozyny, czy adduktu DNA mogą mieć znaczący wpływ na działanie komórki, a co za tym idzie także jej transformację...
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Therapeutic intervention by the simultaneous inhibition of DNA repair and type I or type II DNA topoisomerases: one strategy, many outcomes
PublikacjaMany anticancer drugs reduce the integrity of DNA, forming strand breaks. This can cause mutations and cancer or cell death if the lesions are not repaired. Interestingly, DNA repair-deficient cancer cells (e.g., those with BRCA1/2 mutations) have been shown to exhibit increased sensitivity to chemotherapy. Based on this observation, a new therapeutic approach termed 'synthetic lethality' has been developed, in which radiation...
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The Use of Geodata in the Process of the Ventilation of the City of Krakow
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Removal of Dyes from the Environment by Adsorption Process
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The Influence of Gas Mixture in the Glow-Discharge Nitriding Process of Austenitic Stainless Steel on Characteristic of Nitrided Cases
PublikacjaAustenitic stainless steels characterize with excellent corrosion resistance, although low mechanical properties. In many cases that limits their exploitation in industrial applications. Moreover, austenitic stainless steel is susceptible to local corrosion in the presence of halide ions. In present works, it was emphasized that the nitriding of austenitic stainless steels gives some potential abilities to obtain beneficial effect...
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Termodynamiczne aspekty oddziaływania niskocząsteczkowych ligandów z DNA
PublikacjaKwasy nukleinowe są celem biologicznym dla wielu antybiotyków oraz leków przeciwnowotworowych i przeciwwirusowych. Dlatego podczas tworzenia nowych farmaceutyków ważna jest dokładna wiedza na temat sposobu wiązania się leku do DNA.Oddziaływanie ligand-DNA można podzielić na dwie grupy: 1. wiązanie kowalencyjne, które często prowadzi do utworzenie trwałych wiązań pomiędzy nićmi DNA, 2. fizykochemiczne wiązanie, które może być podzielone...
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Borders of Digital Art in the Context of the Information Society
PublikacjaThe article shows the relationship between the development of information technologies, the characteristics of the information society and digital art. The broad possibilities of the digital world related to recording, storing and processing data (cyber text, big data, smart services) and the creation of virtual worlds are pointed out. The influence of the development of information technologies on the character of the works of...
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Raman spectroscopic study of Ni2+-DNA interactions in aqueous systems
PublikacjaMetodą ramanowskich widm różnicowych określono sposób oddziaływania jonu Ni2+ z DNA(CT) w układach wodnych. Kation Ni(II) koordynuje w pozycjach N7 guaniny (G) i adeniny (A) w powtarzających się sekwencjach GG, AA i GA cząsteczki DNA. Jednocześnie Ni2+ oddziałuje zewnątrz sferowo poprzez cząsteczki wody z grupami fosforanowymi DNA.
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Can architecture be 11-dimensional? The nature of space in the architecture of the digital world era
PublikacjaThis research aims to explore the development of architectural theories about ‘architectural dimensions’ and look at architecture as a multidimensional space. It is important to understand that with today's development of virtual reality technology and through the combination of theories of physics and architecture, a new possibility of creating space has emerged. The arguments are made through inductive reasoning and grounded...
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Coda wave interferometry in monitoring the fracture process of concrete beams under bending test
PublikacjaEarly detection of damage is necessary for the safe and reliable use of civil engineering structures made of concrete. Recently, the identification of micro-cracks in concrete has become an area of growing interest, especially using wave-based techniques. In this paper, a non-destructive testing approach for the characterization of the fracture process was presented. Experimental tests were made on concrete beams subjected to mechanical...
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PROBABILISTIC ANALYSIS OF A SPACE TRUSS BY MEANS OF A MULTIDIMENSIONAL VARIABLE DESCRIPTION
PublikacjaThe objective of this paper is to present a variant of the point estimate method (PEM) to determine mean values and standard deviations of limit loads of engineering structures. This approach is illustrated by limit state analysis of a space truss, considering geometric and material imperfections. The calculations were performed for different random models, so the influence of random parameters on the limit load of the truss can...
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Application of a Gas Sensor Array to Effectiveness Monitoring of Air Contaminated with Toluene Vapors Absorption Process
PublikacjaThis article demonstrates the application of a gas sensor array to monitor the effectiveness of the absorption process of air stream purification from odorous compounds (toluene vapors). A self-constructed matrix consisting of five commercially available gas sensors was used. Multiple linear regression (MLR) was selected as the statistical technique used to calibrate the matrice. Gas chromatography coupled with a flame ionization...
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Combined partial denitrification/anammox process for nitrogen removal in wastewater treatment
PublikacjaRecently, the combined partial denitrification and anammox (PD/anammox) has received special attention as a viable alternative for N removal using organic matter present in municipal wastewater. In comparison with conventional nitrification-denitrification, PD/anammox provides enormous opportunities to achieve sustainable wastewater treatment due to the lack of dissolved oxygen (DO) demand, a smaller amount of organic carbon (C)...
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Adding Intelligence to Cars Using the Neural Knowledge DNA
PublikacjaIn this paper we propose a Neural Knowledge DNA based framework that is capable of learning from the car’s daily operation. The Neural Knowledge DNA is a novel knowledge representation and reasoning approach designed to support discovering, storing, reusing, improving, and sharing knowledge among machines and computing devices. We examine our framework for drivers' classification based on their driving behaviour. The experimental...
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VUV irradiation studies of plasmid DNA in aqueous solution
PublikacjaInteractions of VUV light and DNA samples in aqueous solutions are reported. The damage induced by such radiation is quantified by monitoring both loss of supercoiled DNA and formation of single and double strand breaks using agarose gel electrophoresis. Irradiations were performed using synchrotron VUV photons of 130, 150, 170 and 190 nm. VUV irradiation experiments revealed enhanced damage upon irradiation with 170 nm photons...
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Engineer's graphic workshop. Historical review.
PublikacjaThe paper introduces the history of development of graphic engineering workshop within European culture. The fundamentals of scientific approach to this subject are dated back to the XVIII century. Owning to Gaspard Monge's works descriptive geometry rose to the rank of branch of mathematics. As the time passes we observe the endeavors aiming at accelerating and automating the process of engineering drawing. Since the XX century...
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Effect of the Cavitation Generation Unit Structure on the Performance of an Advanced Hydrodynamic Cavitation Reactor for Process Intensifications
PublikacjaThe advanced rotational hydrodynamic cavitation reactors (ARHCRs) that appeared recently have shown obvious advantages compared with conventional devices in process intensifications. In ARHCRs, the cavitation generation unit (CGU) located on the rotor and stator basically determines their performance. For the first time, the present study investigated the effect of the CGU structure on the performance of a representative ARHCR...
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Klimat pracy zespołu wirtualnego
PublikacjaArtykuł dotyczy klimatu pracy zespołowej, rozumianego jako wspólna dla pracowników zespołu percepcja procesów, praktyk i zachowań, które towarzyszą pracy zespołowej i mają wpływ zarówno na satysfakcję jak i na efekty pracy zespołu. Celem artykułu jest weryfikacja założenia, że wymiary klimatu pracy zespołowej, rozpoznane jako istotne dla zespołów tradycyjnych, mają swoje odzwierciedlenie również we współpracy zespołów wirtualnych....
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Real-time isothermal DNA amplification monitoring in picoliter volumes using an optical fiber sensor
PublikacjaRolling circle amplification (RCA) of DNA can be considered as a great alternative to the gold standard polymerase chain reaction (PCR), especially during this pandemic period, where rapid, sensitive, and reliable test results for hundreds of thousands of samples are required daily. This work presents the first research to date on direct, real-time and label-free isothermal DNA amplification monitoring using a microcavity in-line...
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Wybrane metody badania poziomu metylacji DNA w komórkach eukariotycznych
PublikacjaMetylacja regionów promotorowych jest jednym z głównych mechanizmów regulacji transkrypcji genów u eukariota. W komórkach ssaczych metylacja DNA zachodzi głównie na reszcie cytozyny występującej w dinukleotydach CpG i jest katalizowana przez metylotransferazy DNA (DNMT1, DNMT3A i DNMT3B) (Turek Plewa, Jagodziński 2005). Mapowanie 5 metylocytozyny w DNA genomowym jest jednym z narzędzi do badania wpływu metylacji na tkankowo-specyficzną...
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Decisional experiance: a new approach to intelligent knowledge representation
PublikacjaOmowiono nowe podejscie do reprezentacji wiedzy oparte na modelowaniu i formalizacji doswiadczen decyzyjnych
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Binding free energy of selected anticancer compounds to DNA - theoreticalcalculations
PublikacjaPraca dotyczy swobodnej energii wiązania z DNA trzech związków o działaniu przeciwnowotworowym (mitoksantronu i dwóch pochodnych pirymidoakrydyny). Obliczenia wykorzystywały metody Poissona-Boltzmanna (udział elektrostatyczny) i metody SASA (udział nieelektrostatyczny). W wyniku badań zaproponowano struktury kompleksów jakie tworzą badane ligandy z DNA.
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Molecular Recognition in Complexes of TRF Proteins with Telomeric DNA
PublikacjaTelomeres are specialized nucleoprotein assemblies that protect the ends of linear chromosomes. In humans and many other species, telomeres consist of tandem TTAGGG repeats bound by a protein complex known as shelterin that remodels telomeric DNA into a protective loop structure and regulates telomere homeostasis. Shelterin recognizes telomeric repeats through its two major components known as Telomere Repeat-Binding Factors, TRF1...
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Experience with instantiating an automated testing process in the context of incremental and evolutionary software development
PublikacjaThe purpose of this article is to present experiences from testing a complex AJAX-based Internet-system which is under development for more than five years. The development process follows incremental and evolutionary lifecycle model and the system is delivered in subsequent releases. Delivering a new release involves both, the new tests (related to the new and/or modified functionalities) and the regression tests (after their...
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W poszukiwaniu najlepszego modelu dydaktyki akademickiej
PublikacjaW związku z coraz słabszym przygotowaniem merytorycznym kandydatów na studia, od kilku lat poszukujemy w Polsce modelu dydaktyki akademickiej, który pozwoliłby nam w dalszym ciągu - mimo obniżenia poziomu wiedzy kandydatów przyjętych na studia - na kształcenie studentów na wysokim poziomie. Niestety, w tej chwili nie tylko kształcimy inżynierów, ale również uzupełniamy zaległości powstałe na niższych poziomach edukacji. Wprawdzie...
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Prediction of fracture toughness in fibre-reinforced concrete, mortar, and rocks using various Machine learning techniques
PublikacjaMachine Learning (ML) method is widely used in engineering applications such as fracture mechanics. In this study, twenty different ML algorithms were employed and compared for the prediction of the fracture toughness and fracture load in modes I, II, and mixed-mode (I-II) of various materials, including fibre-reinforced concrete, cement mortar, sandstone, white travertine, marble, and granite. A set of 401 specimens of “Brazilian...
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ZARZĄDZANIE ZESPOŁEM WIRTUALNYM JAKO WYZWANIE DLA LIDERA ZESPOŁU
PublikacjaRozdział dotyczy zarządzania zespołem wirtualnym, który charakteryzuje się rozproszeniem członków zespołu oraz współpracą za pośrednictwem technologii informacyjnej. Tak funkcjonujące zespoły nakładają na lidera dodatkowe wyzwania związane z koniecznością kompensowania braku bezpośredniego kontaktu oraz samodzielnością poszczególnych osób w zespole. Przedstawiono najważniejsze zadania, które podnoszą efektywność zarządzania zespołem...
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H2AX phosphorylation, its role in DNA damage response and cancer therapy
PublikacjaDouble-strand breaks (DSBs) are the most deleterious DNA lesions, which, if left unrepaired, may have severe consequences for cell survival, as they lead to chromosome aberrations, genomic instability, or cell death. Various physical, chemical, and biological factors are involved in DSB induction. Cells respond to DNA damage by activating the so-called DNA damage response (DDR), a complex molecular mechanism developed to detect...
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How proteins bind to DNA: target discrimination and dynamic sequence search by the telomeric protein TRF1
PublikacjaTarget search as performed by DNA-binding proteins is a complex process, in which multiple factors contribute to both thermodynamic discrimination of the target sequence from overwhelmingly abundant off-target sites and kinetic acceleration of dynamic sequence interrogation. TRF1, the protein that binds to telomeric tandem repeats, faces an intriguing variant of the search problem where target sites are clustered within short fragments...
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Methodology for hospital design in architectural education
PublikacjaThe architecture of a hospital should be a response to strong user requirements. Recommendations on how to shape the environment of such facilities are highly complex, integrating guidelines from many fields of science. If contradictions between them exist, the designer is required to set priorities for spatial activities. This issue is particularly important during architectural education. The learning process should include projects...
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Robust Object Detection with Multi-input Multi-output Faster R-CNN
PublikacjaRecent years have seen impressive progress in visual recognition on many benchmarks, however, generalization to the out-of-distribution setting remains a significant challenge. A state-of-the-art method for robust visual recognition is model ensembling. However, recently it was shown that similarly competitive results could be achieved with a much smaller cost, by using multi-input multi-output architecture (MIMO). In this work,...
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Robust Object Detection with Multi-input Multi-output Faster R-CNN
PublikacjaRecent years have seen impressive progress in visual recognition on many benchmarks, however, generalization to the out-of-distribution setting remains a significant challenge. A state-of-the-art method for robust visual recognition is model ensembling. However, recently it was shown that similarly competitive results could be achieved with a much smaller cost, by using multi-input multi-output architecture (MIMO). In this work,...
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Stochastic approach to the dynamics of a linear floating object
PublikacjaArtykuł stanowi prezentację metody różniczkowych równań stochastycznych w zastosowaniu do analizy dynamiki obiektów pływających. Analizowany jest ruch jednostki pływającej jako obiektu liniowego z uwzględnieniem w równaniach stochastycznych nieliniowości, występującej w wymuszeniach zewnętrznych działających na obiekt. Stochastyczne równania różniczkowe są zapisane dla sprzężonych ruchów symetrycznych.
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Object oriented grid computing for computational electromagnetics
PublikacjaArtykuł opisuje bibliotekę WiCommGrid napisaną w języku java, która realizuje ideę wymiany informacji pomiędzy węzłami środowiska rozproszonego z zastosowaniem programowania zorientowanego obiektowo. Biblioteka ta przystosowana jest do współdziałania z wieloma systemami operacyjnymi oraz z rożnym środowiskiem sprzętowym. Zbudowaną aplikację zastosowano do zrównoleglonych obliczeń rozkładu pola elektromagnetycznego w oparciu o algorytm...
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Stochastic approach to the dynamics of marine floating object
PublikacjaAnalizowany jest ruch jednostki pływającej z uwzględnieniem w równaniach stochastycznych nieliniowości, występującej w wymuszeniach zewnętrznych działających na obiekt. Stochastyczne równania różniczkowe są zapisane dla sprzężonych ruchów symetrycznych.