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Design, synthesis, and biological evaluation of tetrahydroquinolinones and tetrahydroquinolines with anticancer activity
PublikacjaColorectal cancer (CRC) is the most commonly diagnosed cancer in Europe and the United States and the second leading cause of cancer related mortality. A therapeutic strategy used for the treatment of CRC involves targeting the intracellular levels of reactive oxygen species (ROS). In this study, we synthesized a series of novel tetrahydroquinolinones and assessed their ability to inhibit CRC growth and proliferation by evoking...
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Influence of Surface Laser Treatment on Mechanical Properties and Residual Stresses of Titanium and its Alloys
PublikacjaSurface modification of the titanium and its alloys used in implantology with a long-pulse laser can change the surface topography, but it also leads to changes in the stress sign and magnitude in the resulting subsurface layer. The presented research was aimed at evaluating the state of stress after laser remelting with the Nd:YAG laser of pre-etched titanium alloys Ti6Al4V and Ti13Nb13Zr and pure titanium. The obtained surface...
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Recent Achievements in Constitutive Equations of Laminates and Functionally Graded Structures Formulated in the Resultant Nonlinear Shell Theory
PublikacjaThe development of constitutive equations formulated in the resultant nonlinear shell theory is presented. The specific features of the present shell theory are drilling rotation naturally included in the formulation and asymmetric measures of strains and stress resultants. The special attention in the chapter is given to recent achievements: progressive failure analysis of laminated shells and elastoplastic constitutive relation...
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CPTU/DMT control of heavy tamping compaction of sands
PublikacjaHeavy tamping compaction method in cohesionless alluvial soil was evaluated with CPTU and DMT tests. Some examples of interpretation of soundings in pre-treated and compacted sands are given. The compaction work was performed in two stages. Compaction control was performed after each stage of tamping. Additional tests were performed two weeks after the compaction works completion to study the set-up effect. While typical increase...
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Numerical modelling of the mesofracture process of sintered 316L steel under tension using microtomography
PublikacjaThis paper concerns numerical modelling of the deformation process, taking into account the local fracture of porous 316L sinters at the mesoscopic scale using the finite element method. Calculations are performed with the use of geometrical models, to map the realistic shape of the porous mesostructure of the material, obtained by means of computed microtomography. The microtomographic device has limited and insufficient measurement...
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Local buckling of composite channel columns
PublikacjaThe investigation concerns local buckling of compressed flanges of axially compressed composite channel columns. Cooperation of the member flange and web is taken into account here. The buckling mode of the member flange is defined by rotation angle a flange about the line of its connection with the web. The channel column under investigation is made of unidirectional fibre-reinforced laminate. Two approaches to member orthotropic...
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Evaluating Pornography Problems Due to Moral Incongruence Model
PublikacjaIntroduction To date, multiple models of problematic pornography use have been proposed, but attempts to validate them have been scarce. Aim In our study, we aimed to evaluate the Pornography Problems due to Moral Incongruence model proposing that self-appraisals of pornography addiction stem from (i) general dysregulation, (ii) habits of use, and (iii) moral incongruence between internalized norms and behavior. We investigated...
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Nowe substancje psychoaktywne CZ. II. SYNTETYCZNE KANNABINOIDY - CHARAKTERYSTYKA, METODY OZNACZANIA I WYZWANIA ANALITYCZNE
PublikacjaDo nielegalnego obrotu co roku trafiają nowe związki o działaniu psychoaktywnym. Dostęp do takich substancji nie jest trudny, gdyż są one łatwo dostępne w wielu krajach, głównie w sklepach internetowych. Ponadto, organy ścigania i wymiar sprawiedliwości nie nadążają z wprowadzaniem tych substancji na listy substancji zakazanych przez co ich kontrola jest bardzo utrudniona. Syntetyczne kannabinoidy to grupa związków chemicznych,...
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More Than just Antioxidants: Redox-Active Components and Mechanisms Shaping Redox Signalling Network
PublikacjasettingsOrder Article Reprints This is an early access version, the complete PDF, HTML, and XML versions will be available soon. Open AccessReview More Than just Antioxidants: Redox-Active Components and Mechanisms Shaping Redox Signalling Network by Monika Kuczyńska,Patrycja Jakubek andAgnieszka Bartoszek *ORCID Faculty of Chemistry, Gdańsk University of Technology, 80-233 Gdańsk, Poland * Author to whom correspondence should...
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Assessment of tensile forces in Sopot Forest Opera membrane by in situ measurements and iterative numerical strategy for inverse problem
PublikacjaAssessment of tensile forces in newly build Sopot Forest Opera roofing membrane is presented. The procedure is based on in situ measurements and solution of the inverse problem by an iterative procedure. The goal of the analysis is to determine whether the stress state of the membrane is consistent with the design assumptions. The paper contains the description of measurements, used instruments, applied loadings, numerical investiga-tions...
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Hydrogen induced degradation of structural steel exposed to the technical liquid hydrocarbons
PublikacjaSusceptibility of the differently heat treated 26H2MF steel to stress corrosion cracking has been evaluated in the constant strain rate tension tests done at the strain rate 10-6s-1 and in the constant load tests done at the 0,98 of fracture load. The boiler fuel and the aged mineral oil at 135C and 80C respectively, have been used as the aggressive environments.
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The Business Environment of Georgia and Ukraine: Approaches to a Comparative Analysis
PublikacjaThe formation of a favourable business environment and the intensification of entrepreneurial activity on this basis is one of the priorities of economic policy of governments around the world. The aim of this article is to conduct a comparative analysis of some of the characteristics of the business environment of Georgia and Ukraine. The theoretical basis of the study is the understanding of the business environment as a necessary...
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Osoby starsze wobec innowacyjnych form świadczenia usług ubezpieczeniowych
PublikacjaPrzedmiotem zainteresowania badawczego w niniejszym tekście są usługi ubezpieczeniowe świadczone z wykorzystaniem innowacyjnych środków komunikacji: Internetu lub telefonu. W artykule skoncentrowano się na osobach powyżej 50 roku życia, szczególnie narażonych na zjawisko wykluczenia cyfrowego. Na podstawie przeglądu literatury sformułowano hipotezę badawczą: Cechy społeczno – demograficzne osób powyżej 50 roku życia wpływają na ich...
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Influence of meniscus shape in the cross sectional plane on the knee contact mechanics
PublikacjaWe present a three dimensional finite element analysis of stress distribution and menisci deformation in the human knee joint. The study is based on the Open Knee model with the geometry of the lateral meniscus which shows some degenerative disorders. The nonlinear analysis of the knee joint under compressive axial load is performed. We present results for intact knee, knee with partial and complete radial posterior meniscus root...
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Applying molecular dynamics simulation to take the fracture fingerprint of polycrystalline SiC nanosheets
PublikacjaGraphene-like nanosheets are the key elements of advanced materials and systems. The mechanical behavior of the structurally perfect 2D nanostructures is well documented, but that of polycrystalline ones is less understood. Herein, we applied molecular dynamics simulation (MDS) to take the fracture fingerprint of polycrystalline SiC nanosheets (PSiCNS), where monocrystalline SiC nanosheets (MSiCNS) was the reference nanosheet....
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Comparitive study of heat transfer and pressure drop during flow boiling and flow condensation in minichannels
PublikacjaIn the paper a method developed earlier by authors is applied to calculations of pressure drop and heat transfer coefficient for flow boiling and also flow condensation for some recent data collected from literature for such fluids as R404a, R600a, R290, R32,R134a, R1234yf and other. The modification of interface shear stresses between flow boiling and flow condensation in annular flow structure are considered through incorporation...
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ENVIRONMENTAL DEGRADATION OF DISSIMILAR AUSTENITIC 316L AND DUPLEX 2205 STAINLESS STEELS WELDED JOINTS
PublikacjaThe paper describes structure and properties of dissimilar stainless steels welded joints between duplex 2205 and austenitic 316L steels. Investigations were focused on environmentally assisted cracking of welded joints. The susceptibility to stress corrosion cracking (SCC) and hydrogen embrittlement was determined in slow strain rate tests (SSRT) with the strain rate of 2.2 × 10–6 s–1. Chloride-inducted SCC was determined in the...
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On the crack front curvature in bonded joints
PublikacjaStandard tests of adhesively bonded specimens are likely to produce heterogeneous stress distribution along the crack front and its vicinity. High separation rate mode I dominated fracture test is performed.Observation of post mortem fractured surfaces with an optical microscope reveals characteristic features of mixed mode I/III fracture near the sides of the specimen but not in the middle. At first, finite elements calculations...
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On local buckling of cold-formed channel members
PublikacjaThe paper deals with local buckling of the compressed flanges of cold-formed thin-walled channel beams subjected to pure bending or axially compressed columns. Arbitrarily shaped flanges of open cross-sections and the web-flange interactions are taken into account. Buckling deformation of a beam flange is described by displacement related to torsion of the flange about the line of its connection with the web. Total potential energy...
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The effect of external load on ultrasonic wave attenuation in steel bars under bending stresses
PublikacjaThe stress state in deformed solids has a significant impact on the attenuation of an ultrasonic wave propagating through the medium. Measuring a signal with certain attenuation characteristics can therefore provide useful diagnostic information about the stress state in the structure. In this work, basic principles behind a novel attenuation-based diagnostic framework are introduced. An experimental study on steel bars under three-point...
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Effect of surface on the flexomagnetic response of ferroic composite nanostructures; nonlinear bending analysis
PublikacjaOur analysis incorporates the geometrically nonlinear bending of the Euler-Bernoulli ferromagnetic nanobeam accounting for a size-dependent model through assuming surface effects. In the framework of the flexomagnetic phenomenon, the large deflections are investigated referring to von-Kármán nonlinearity. Employing the nonlocal effects of stress coupled to the gradient of strain generates a scale-dependent Hookean stress-strain...
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Stability analysis of nanobeams in hygrothermal environment based on a nonlocal strain gradient Timoshenko beam model under nonlinear thermal field
PublikacjaThis article is dedicated to analyzing the buckling behavior of nanobeam subjected to hygrothermal environments based on the principle of the Timoshenko beam theory. The hygroscopic environment has been considered as a linear stress field model, while the thermal environment is assumed to be a nonlinear stress field based on the Murnaghan model. The size-dependent effect of the nanobeam is captured by the nonlocal strain gradient...
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Slowly-closing valve behaviour during steam machine accelerated start-up
PublikacjaThe paper discusses the state of stress in a slowly-closing valve during accelerated start-up of a steam turbine. The valve is one of the first components affected by high temperature gradients and is a key element on which the power, efficiency and safety of the steam system depend. The authors calibrated the valve model based on experimental data and then performed extended Thermal-FSI analyses relative to experiment. The issue...
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Participatory Budgeting in Poland – Missing Link in Urban Regeneration Process
PublikacjaIn last thirty years Poland has gone a long way toward democracy and decentralization. Role of public participation in planning is increasing rapidly and recently many new instruments of empowering the community is being introduced, participatory budgeting is one of the most important. On the other hand, urban regeneration is one of the most important challenges of polish cities are facing. Technical and transport infrastructure...
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Importance of sign conventions on analytical solutions to the wave-induced cyclic response of a poro-elastic seabed
PublikacjaThis paper discusses the influence of different sign conventions for strains and stresses, i.e. the solid mechanics sign convention and the soil mechanics sign convention, on the form of governing partial differential equations (the static equilibrium equations and the continuity equation) used to describe the wave-induced cyclic response of a poro-elastic seabed due to propagation of a sinusoidal surface water-wave. Some selected...
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Calculation of Induced Sheath Voltages in Power Cables – Single Circuit System versus Double Circuit System
PublikacjaThis paper presents comparison of values of induced sheath voltages in power cable metallic sheaths when one or two cables per phase are used. Calculation of voltages is performed for various phase sequences of the power cables. Three types of the sheaths bonding and earthing are considered. Shock hazard and voltage stress of non-metallic outer sheath of cables are evaluated. The proposed, optimal configuration of the power cable...
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HPLC-coupled post-column derivatization aims at characterization and monitoring of plant phytocomplexes, not at assessing their biological properties
PublikacjaTwo recent decades of research identified a number of environmental factors as well as mechanisms leading to pathogenic processes in the human organism. A common factor in pathogenesis of many diseases is oxidative stress, a condition in which the production of damaging reactive oxygen species (ROS), present in the body as an inevitable consequence of respiration and exacerbated by the inflammatory response and by exogenous factors...
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Konkurencyjność w handlu usługami wybranych krajów Europy Środkowo-Wschodniej
PublikacjaCelem artykułu jest ocena pozycji konkurencyjnej w handlu usługami wybranych krajów Europy Środkowo-Wschodniej – Czech, Estonii, Litwy, Łotwy, Polski, Słowacji oraz Węgier na tle gospodarki światowej. Dane wykorzystane do analizy pochodzą z bazy danych WIOD i obejmują lata 1995 – 2011. Podstawą oceny pozycji konkurencyjnej jest wskaźnik RCA obliczony na podstawie krajowej wartości dodanej oraz na podstawie eksportu brutto. Źródłem...
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Wartości rekomendowane wskaźników sprawności działania dla przedsiębiorstw z sektora MSP
PublikacjaNiniejszy artykuł poświęcony jest zagadnieniu sprawności działania małych i średnich przedsiębiorstw. W trakcie przeprowadzonych badań wykorzystano 34 820 sprawozdania finansowe przedsiębiorstw. Dla potwierdzenia zróżnicowania sprawności działania w zależności od przynależności sektorowej przedsiębiorstwa wykorzystano test nieparametryczny Kruskala – Wallisa. Zawarte w artykule wyniki badań dowodzą, że MSP należące do różnych działów...
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INWESTYCJE A ZATRUDNIENIE W POLSCE W PERSPEKTYWIE FINANSOWE 2007-2013
PublikacjaNakłady inwestycyjne przedsiębiorstw traktowane są jako jeden z głównych czynników wzrostu gospodarczego. Ich wielkość i dynamika mogą mieć wpływ na zmiany w poziomie zatrudnienia. Światowy kryzys finansowy przyczynił się do spowolnienia dynamiki wzrostu oraz gwałtownego spadku w 2009 roku PKB w większości gospodarek świata. We wspomnianym okresie w Polsce zaobserwowano spowolnienie gospodarcze, które miało wpływ na decyzje...
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Tradycyjne i nowoczesne kanały dystrybucji wykorzystywane w procesie świadczenia usług ubezpieczeniowych dojrzałym konsumentom
PublikacjaPrzedmiotem artykułu są usługi ubezpieczeniowe świadczone z wykorzystaniem tradycyjnych i nowoczesnych kanałów dystrybucji. W artykule skoncentrowano się na osobach powyżej 50 roku życia, szczególnie narażonych na zjawisko wykluczenia cyfrowego. Na podstawie przeglądu literatury sformułowano hipotezę badawczą: cechy społeczno – demograficzne osób powyżej 50 roku życia wpływają na ich skłonność do korzystania z usług ubezpieczeniowych...
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Alkohol-społeczny problem XXI wieku. Zastosowanie biowskaźników spożywania alkoholu w diagnostyce medycznej.
PublikacjaAlkohol etylowy jest legalną i ogólnodostępną substancją o działaniu psychoaktywnym. Spożywany w niewielkich ilościach może pozytywnie wpływać na zdrowie, ale jego nadmierna konsumpcja powoduje silne uzależnienie. Może być to przyczyną agresywnych zachowań, przemocy w rodzinie, problemów w kontaktach z ludźmi, problemów z prawem, samobójstw, wypadków samochodowych oraz problemów finansowych. Dlatego też, szybka i jednoznaczna diagnostyka...
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Metoda diagnostyki łożysk na podstawie analizy przebiegów prądu i napięcia zasilającego silnik indukcyjny.
PublikacjaW niniejszej monografii przedstawiono oryginalne podejście i realizację diagnostyki łożysk silników indukcyjnych przy użyciu metody opartej na pomiarach i analizie iloczynu wartości chwilowych prądu i napięcia zasilającego maszyny. Uzyskane wyniki badań eksperymentalnych na obiektach rzeczywistych okazały się zbieżne z wynikami badań symulacyjnych i potwierdziły, że powstanie uszkodzeń łożysk w silniku skutkuje pojawieniem się...
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Wzmocnienie przestrzennych dźwigarów kratowych z zastosowaniem dodatkowego podparcia i sprężenia
PublikacjaPodczas obowiązkowego przeglądu technicznego obiektu budowlanego stwierdzone zostały deformacje stalowych prętów wykratowania przestrzennych dźwigarów dachowych. Opinie techniczne dotyczące stanu technicznego potwierdziły wstępnie wykryte nieprawidłowości i nakazywały podjęcie kroków zaradczych w postaci opracowania koncepcji naprawy, a w jej ślad projektu budowlanego i wykonawczego. Do czasu naprawy obiekt został dopuszczony do...
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Does pandemic denial help or harm? Belief in COVID-19 and experience of it affect psychological consequences of using neurotic defence mechanisms
PublikacjaObjective: The COVID-19 pandemic may activate thoughts of death, leading to aversive psychological states. In such situations, defence mechanisms emerge; however, their adaptability depends on many factors. The aim of the study was to investigate the relationship between neurotic defence style and depressive symptoms. We assumed that the sense of coherence underlies this correlation and investigated how both believing (or not)...
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Evaluation of Asphalt Mixture Low-Temperature Performance in Bending Beam Creep Test
PublikacjaLow-temperature cracking is one of the most common road pavement distress types in Poland. While bitumen performance can be evaluated in detail using bending beam rheometer (BBR) or dynamic shear rheometer (DSR) tests, none of the normalized test methods gives a comprehensive representation of low-temperature performance of the asphalt mixtures. This article presents the Bending Beam Creep test performed at temperatures from −20...
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Entire fracture surface topography parameters for fatigue life assessment of 10H2M steel
PublikacjaIn this paper, the entire fracture surface approach was used to assess an effect of 280,000 h of exploitation under internal pressure of 2.9 MPa and high temperature of 540 °C on the fatigue response of 10H2M (10CrMo9–10) power engineering steel. The mechanical testing was carried out on the hourglass specimens produced from the as-received, unused pipeline and the same material after long-time exploitation. The uniaxial tensile...
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Experimental-Numerical Analysis of the Effect of Bar Diameter on Bond in Pull-Out Test
PublikacjaBar diameter is one of the basic factors affecting bond behavior, which is still of interest due to opposing opinions regarding its effect on bond behavior in the pull-out test. This paper presents an experimental and numerical bond analysis of ribbed reinforcing bar in concrete. The aim was to experimentally evaluate the effect of bar diameter on the bond behavior in the pull-out test and to perform numerical simulations of the...
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Modelling tunnelling-induced deformation in stiff soils with a hyperelastic–plastic anisotropic model
PublikacjaIn this paper, the tunnelling-induced deformation in anisotropic stiff soils is analysed using FE modelling. The influence of material description is investigated rather than an advanced simulation of the tunnelling method. A new hyperelastic– plastic model is proposed to describe the anisotropic mechanical behaviour of stiff highly overconsolidated soil. This model can reproduce the superposition of variable stress-induced anisotropy...
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Experimental observations on the creep behaviour of frozen soil
PublikacjaConstitutive models in the literature for creep of frozen soil are based on the direct use of time counted from the onset of creep. An explicit time dependence in a constitutive equation violates the principles of rational mechanics. No change in stress or temperature is allowed for during creep, using the time-based formulations. Moreover, the existing descriptions need much verification and improvement on the experimental side...
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Endothelial Dysfunction Driven by Hypoxia—The Influence of Oxygen Deficiency on NO Bioavailability
PublikacjaCardiovascular diseases (CVDs) are the leading cause of death worldwide. The initial stage of CVDs is characterized by endothelial dysfunction, defined as the limited bioavailability of nitric oxide (NO). Thus, any factors that interfere with the synthesis or metabolism of NO in endothelial cells are involved in CVD pathogenesis. It is well established that hypoxia is both the triggering factor as well as the accompanying factor...
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Incorporating installation effects into the probability analysis of controlled modulus columns
PublikacjaThis technical report presents the probabilistic analysis which integrates the Monte Carlo simulation (MCS) with random field theory to model the load–displacement behavior of Controlled Modulus Columns (CMCs) in overconsolidated Poznań clay. Presented study focuses on the practical aspects of statistical analysis of geotechnical data, numerical model development, and results evaluation. Variability and spatial distribution of...
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Diagnostics of bolted lap joint using guided wave propagation
PublikacjaThe paper presents numerical and experimental analyses of elastic waves propagation in a bolted lap joint. In experimental investigations condition assessment of the joint was performed with the use of symmetric waves excited by a piezoactuator. Numerical calculations were conducted in commercial finite element method software Abaqus. The influence of number of bolts and the value of the initial stress on recorded signals was examined....
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Corporate social responsibility and forward default risk under firm and industry heterogeneity
PublikacjaObjective: This study aims to evaluate the impact of corporate social responsibility on forward default risk (FDR) under the setting of firm and industry heterogeneity. Research Design & Methods: This study evaluated the impact of corporate social responsibility (CSR) on FDR using the data of 497 companies from 2007-2021 in the S&P 500 index, taking into account firm and industry heterogeneity aspects. This study utilized instrumental...
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Gender as a Moderator of the Double Bias of Mistakes – Knowledge Culture and Knowledge Sharing Effects
PublikacjaThere is no learning without mistakes. The essence of the double bias of mistakes is the contradiction between an often-declared positive attitude towards learning from mistakes, and negative experiences when mistakes occur. Financial and personal consequences, shame, and blame force desperate employees to hide their mistakes. These adverse outcomes are doubled in organizations by the common belief that managers never make mistakes,...
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The Response of Selected Domestic Capital Markets on the Development of COVID-19 Pandemic – a Broader View
PublikacjaObjective: The study examines how the record of the first, hundredth, thousandth, ten-thousandth, one-hundred-thousandth, and millionth cases of COVID-19 affected investor behaviour in capital markets. It also looks at whether the month in which the first case was recorded in a given market affected the direction and strength of investor reactions. Lastly, it verifies whether the two announcements made by the WHO related to COVID-19...
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Modelling of Different Aeration Modes Influencing Processes in SBR Bioreactor
PublikacjaCurrently, computer modelling together with the simulation tools tailored for that purpose constitute a very important element in planning technological changes within wastewater treatment plant. From the point of view of the WWTP operator every modification should be introduced in order to improve the quality of treated sewage with the lowest financial outlays. These requirements can be met by using computer programmes to effectuate...
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Knowledge Management for Managing Crisis in Tourism: Theoretical insights
PublikacjaCOVID-19 has caused an unprecedented crisis affecting the entire tourism industry. Accommodation, food, and travel sectors have been affected by the decreased number of visitors, which had a ripple effect on the financial situation of the whole industry. The purpose of this work is a better understanding of the role of knowledge management in terms of mitigating the crisis in the tourism sector, as well as a development of the...
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Analysing Ways to Achieve a New Urban Agenda-Based Sustainable Metropolitan Transport
PublikacjaThe New Urban Agenda (NUA) sets a new vision of sustainable urban development to help cities deal with the challenges of changing demography. While numerous articles have addressed how the NUA can be implemented at different levels and in different areas, this article points out the potential limitations in incorporating the NUA into metropolitan transport policies. The relevance of the limitations can be seen in three main fields:...
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Exchange-traded products in Germany: development and substitution of exchange-traded funds, exchange-traded commodities and exchange-traded notes.
PublikacjaResearch background: Exchange-traded products (ETPs) are one of the most rapidly growing categories of financial products. Their fast development has been boosted by innovative features. Three main categories of ETPs are exchange-traded funds (ETFs), exchange-traded commodities (ETCs) and exchange-traded notes (ETNs). ETCs and ETNs remain least known, even though their number on some stock exchanges is high. In Europe, Germany...