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Towards β-selectivity in functional estrogen receptor antagonists
PublikacjaBased on the benzo[b]naphtho[1,2-d]furan and benzo[b]naphtho[1,2-d]thiophene frameworks, a series of ligands with different basic side chains (BSCs) has been synthesized and pharmacologically evaluated. Also, their binding modes have been modelled using docking techniques. It was found that the introduction of a BSC in these systems brings about a decrease of affinity for both estrogen receptors α and β in an in vitro competitive...
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Specific Binding of Cholesterol to the Amyloid Precursor Protein: Structure of the Complex and Driving Forces Characterized in Molecular Detail
PublikacjaC99 is the C-terminal membrane-bound fragment of the amyloid precursor protein that is cleaved by γ-secretase to release Aβ peptides, the hallmark of Alzheimer’s disease (AD). Specific interactions of C99 with cholesterol have been proposed to underlie the recognized role of cholesterol in promoting amyloidogenesis. By using molecular dynamics simulations, we studied cholesterol binding to C99 in a lipid bilayer. We determined...
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The Impact of Information and Communication Technology on the Rise of Urban Social Movements in Poland
PublikacjaThe chapter examines the relationship between the use of Information and Communications Technology (ITC) and the emergence of social movements focused on urban agenda in Poland. The aim is to investigate how and to what extent a growing body of smaller activist groups use opportunities provided by the ITC to achieve their political objectives. The research results indicate that Web-based media have helped to raise the profile...
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The Impact of Information and Communications Technology on the Rise of Urban Social Movements in Poland
PublikacjaThe chapter examines the relationship between the use of Information and Communications Technology (ITC) and the emergence of social movements focused on urban agenda in Poland. The aim is to investigate how and to what extent a growing body of smaller activist groups use opportunities provided by the ITC to achieve their political objectives. The research results indicate that Web-based media have helped to raise the profile of...
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Improvement of opipramol base solubility by complexation with β-cyclodextrin
PublikacjaOpipramol (OPI), a tricyclic antidepressant and anxiolytic compound, is administered orally in the form of a dihydrochloride. Salt form of the drug has a higher solubility in water and hence bioavailability and stability. A similar effect can be achieved by closing the hydrophobic part of the drug molecule in the cyclodextrin cavity. The paper presents opipramol inclusion complexes with beta-cyclodextrin (β-CD) in 1:1 molar ratio....
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Active Power Quality Controllers
PublikacjaDynamic Static Synchronous Compensator is the most important controller for distribution networks and probably in SEEN. It has been widely used since the 1990s to regulate system voltage precisely, improve voltage profile, reduce voltage harmonics, reduce transient voltage disturbances and load compensation. Rather than using conventional capacitors and inductors combined with fast switches, the D-STATCOM uses a power-electronics...
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Selected aspects of the surface quality of the wooden elements after planing
PublikacjaThe quality of the surface of wooden elements, that have been planed, has got a crucial meaning in the whole production process flow, since the obtained effects affect the quality of wooden surface after painting. The emergence of defects in most cases causes need to qualify workpiece as a scrap part or additional work activity must be done. In the paper selected results of the investigation of the effect of the cutting tool wear...
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Health-Promoting Effects of Ethylene-Treated Kiwifruit ‘Hayward’ from Conventional and Organic Crops in Rats Fed an Atherogenic Diet
PublikacjaKiwifruit is a subtropical fruit that is very popular among consumers. Kiwifruit ‘Hayward’ (Actinidia deliciosa C.F. Liang et A.R. Ferguson) is an important source of bioactive compounds and possesses high antioxidant capacity, but its value can be changed during ripening. The aim of this study was to compare the levels of total polyphenols (TP), ascorbic acid (AA), and total antioxidant capacities (TACs) of ethylene-treated and...
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Innovative cold-formed GEB section under compression
PublikacjaCold-formed steel sections extensively affect the modern steel construction industry. Not only are they used as secondary elements like purlins or sheeting, but also they can serve as primary load-bearing members in fabricated steel panels and trusses. A new cross-section called shortly a GEB may serve as that member. However, its existence of the metal building structures industry depends on the exact, optimal dimensional parameters...
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Conception for diagnosing SI engines fed with biofuel in operation conditions
PublikacjaThe article deals with the question of diagnosing the high power self ignition (SI) engines fed with pro-ecologic fuels in an aspect of appearing operation problems. There has been presented the specific of action and techno-operation profile of the combustion engine foreseen as an investigations object. The preliminary conception of diagnostic investigations of the engine 7L35MC type produced in H. Cegielski - Poznan S.A. factory...
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Numerical Study on Seismic Response of a High-Rise RC Irregular Residential Building Considering Soil-Structure Interaction
PublikacjaThe objective of the present study is to investigate the importance of soilstructure interaction effects on the seismic response of a high-rise irregular reinforced-concrete residential building. In order to conduct this research, a detailed three-dimensional structure model was subjected to various earthquake excitations, also including a strong mining tremor. Soil-foundation flexibility was represented using the spring-based...
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Theoretical and Economic Evaluation of Low-Cost Deep Eutectic Solvents for Effective Biogas Upgrading to Bio-Methane
PublikacjaThis paper presents the theoretical screening of 23 low-cost deep eutectic solvents (DESs) as absorbents for effective removal of the main impurities from biogas streams using a conductor-like screening model for real solvents (COSMO-RS). Based on thermodynamic parameters, i.e., the activity coefficient, excess enthalpy, and Henry’s constant, two DESs composed of choline chloride: urea in a 1:2 molar ratio (ChCl:U 1:2), and choline...
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The impact of cold plasma on the phenolic composition and biogenic amine content of red wine
PublikacjaThe effect of cold plasma (CP) on phenolic compound (PC) and biogenic amine (BA) contents of red wine was investigated for the first time. The influence of CP was compared with the effects of a wine preservation using potassium metabisulfite and a combined method. The PC profile was determined by UPLC-PDA-MS/MS while BAs using DLLME-GC–MS. Chemometric analysis also was used. The content of PCs was 3.1% higher in the sample preserved...
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The Influence of the Co-Dopant Dexamethasone Phosphate on the Electrodeposition Process and Drug-Release Properties of Polypyrrole-Salicylate on Iron
PublikacjaIn this work, the influence of incorporation of two anti-inflammatory drugs dexamethasone phosphate and sodium salicylate on the electrodeposition process of polypyrrole (PPy) film on iron has been studied. The incorporation of the agents into PPy has been carried out in a one-step electropolymerization process on oxidizable iron. The role of each drug agent during the deposition process has been discussed. The morphological and...
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Molecular characterization of a cryptic plasmid from the psychrotrophic antarctic bacterium Pseudoalteromonas sp. 643A
PublikacjaW ostatnich latach znacznie wzrosło zainteresowanie organizmami zimnolubnymi, głównie z powodu ich enzymów o biotechnologicznym znaczeniu. Jednak, aby wydajnie produkować takie enzymy w skali przemysłowej użyteczne jest stworzenie rekombinantowych systemów ekspresyjnych, które pozwolą na ich opłacalną produkcję. W osiągnięciu tego celu mogą pomóc odpowiednie wektory, konstruowane na bazie plazmidów pozyskiwanych z bakterii psychrofilnych/psychrotrofowych....
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Analiza in silico bioaktywnych peptydów pochodzących z keratyny z piór drobiowych
PublikacjaKeratyna należy do najbardziej powszechnie występujących białek strukturalnych pochodzenia zwierzęcego. Stanowi ok. 90% masy piór wytwarzanych w dużych ilościach przez przemysł drobiarski. Ten odpadowy produkt pozostaje w dużym stopniu niezagospodarowany. Celem pracy była analiza bioinformatyczna pierwszorzędowej struktury keratyny z piór kurzych pod kątem występowania w niej peptydów bioaktywnych....
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Imidazoacridinone C-1311 induces both autophagy and senescence in human lung cancer A549 cells
PublikacjaNiedrobnokomórkowy rak płuc (ang. NSCLC, non-small cell lung cancer), stanowiący blisko 80-87% wszystkich przypadków, jest najczęściej występującą formą raka płuc. Skuteczność dotychczas stosowanych chemoterapeutyków w stosunku do tej formy raka jest bardzo ograniczona dlatego poszukuje się nowych związków o lepszych właściwościach leczniczych. Imidazoakrydon C-1311 wykazuje wysoką aktywność cytotoksyczną wobec komórek niedrobnokomórkowego...
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Drainage and capillary rise components in water balance of alluvial soils
PublikacjaPrzepływ wody przez dolny brzeg profilu glebowego stanowi ważny element wielu modeli pracy drenażu. Przeciekanie wody w głąb albo podsiąk kapilarny ku górze mierzone były metodą lizymetryczną w warunkach polowych podczas 4 lat (1972-1975). Podsiąk kapilarny wynosił 40-50% ogólnego zasilania w wodę w glebach typu Histosols, natomiast prawie zero w glebach typu Inceptisols. Pomierzone wartości pozwalaja na ocenę wymiany wody pomiedzy...
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THE INFLUENCE OF QUESTION SET ON STUDENT QUIZ RESULTS
PublikacjaThe advent of e-Learning tools allowing for automated online test grading will probably increase the frequency of using tests in technical education. The same tools may provide for measures of test question quality. By purposely crafting question sets, test grading may serve different goals. The paper contains examples and test study with score histograms.
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Metals in the environment as risk factors for infectious diseases: gaps and opportunities
PublikacjaThis chapter aims to provide insights into current knowledge and gaps in our understanding of the influence that trace metals in the environment have on the pathogenesis of infectious diseases. By reducing immune function, trace metal deficiencies may substantially contribute to the global burden of diarhea, pneumonia, and malaria. Improved methods and biomarkers for assessing the risk of trace metals deficiencies and toxicities...
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Supporting First Year Students Through Blended-Learning - Planning Effective Courses and Learner Support
PublikacjaHigher education has been actively encouraged to find more effective and flaxible delivery models to provide all students with access to good quality learning experiences. This paper describes students opinion about using e-learning techniques and their participation in courses provided in different ways as additional help and expectations of first year students.
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Social development and ICT adoption. Recent evidence from developing world
PublikacjaThis paper is designed to provide empirical evidence on the relationship between the process of ICT diffusion and social development across selected low-income and lowermiddle- income countries during the period of 2000 and 2014. It main target it so identify whether in low-income and lower-middle-income economies, ICT development and social development (social empowerment) are correlated.
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Female entrepreneurship in transitional economies: the case of Poland
PublikacjaPolska przeszła skomplikowaną drogę przemian gospodarczych by ostatecznie wstąpić do UE. Jednę z sił, pomocnych na tej drodze była i jest przedsiębiorczość. Autorzy podjęli się charakterystyki przedsiębiorczości kobiet w okresie transformacji, porównując ją z przedsiębiorczością w pozostałych 15 krajach UE (przed akcesją Polski). Wykorzystano do tego badania przeprowadzone w 1992, 1999 i 2004 wśród przedsiębiorców regionu gdańskiego....
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Wysokociśnieniowe uszczelnienia ruchu obrotowego wału hydraulicznych maszyn wyporowych
PublikacjaW artykule przedstawiono wyniki badań mające na celu wytypowanie węzła uszczelniającego wał silnika hydraulicznego zapewniającego najwyższą trwałość przy smarowaniu wodą. Parametry pracy: ciśnienie 2 MPa i minimalna prędkość poślizgu uszczelek 2 m/s. Opisano również nowatorski przyrząd, na którym przeprowadzono pomiary wszystkich parametrów węzła uszczelniającego.
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USŁUGA RÓWNOWAŻENIA OBCIĄŻENIA W SYSTEMIE OPENSTACK
PublikacjaNiniejszy artykuł ma na celu pokazanie funkcjonowania równoważenia obciążenia dla serwisu Neutron odpowiedzialnego za tworzenie i obsługę usług sieciowych dla użytkowników OpenStack’a. Stanowi on podstawę do zapewnienia komunikacji wewnątrz systemowej, z systemem jak i z wewnętrznymi prywatnymi sieciami systemowymi. W artykule przedstawiono wyniki bazując na edycji Juno, którą zaimplementowano w celu przeprowadzenia badań i analizy...
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30 years of treatment wetland application in poland- progress and reserch
PublikacjaThe experiences with design and operation of constructed wetlands in the Pommerania region during last 30 years followed by carried out investigations of treatment processes lead to the following conclusions:First applications of constructed wetlands for biological sewage treatment were made in 1984-92. The later implementations of multi-stage constructed wetlands in the individual household and local scale enable wastewater treatment...
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CSR in Family Business- Ethnocentric Meaning Socially Responsible?
PublikacjaThe aim of this paper is to provide framework and key issues relevant for research on social responsibility of family business. From providing two theoretical approaches towards social responsibility such as social capital concept commenting on the familiness as a family firm resource and capability; and the stakeholder theory we move to the state of the art of family business. Then, we discuss heterogeneity among family firms...
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A HISTORICAL BUILDING'S RESTORATION IN THE CONSTRUCTIONAL ASPECT ON THE EXAMPLE OF A BUILDING LOCATED IN POLAND
PublikacjaObjects of cultural heritage are an extremely important element in the proper functioning of the social life. They provide information on our ancestors' actions, as well as shape our culture and social awareness. It is important for the historical objects to provide those information accurately, that is without any unnecessary human intervention over the years of the monument's existence. However, it is not always possible due...
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Ancient settlements-atavistic solutions for present water supply and drainage problems engendered by urbanism
PublikacjaWater is the most valuable resource available on earth. Although it is present in abundance, its usable volume is very scarce. This is the reason behind the existence of both floods and droughts around the world. However, human settlements face water scarcity issues that are primarily engendered by improper town planning measures. To create a balance between the available fractions of water, it is therefore imperative to have proper...
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Integrated Three-Level Dual-Phase Inverter
PublikacjaIn view of reducing the number of inverter legs that provide dual-phase, three-level output voltages (as may be needed in an uninterruptible power supply), and that also provide a wide range of output frequencies (as needed in an advanced motor drive system with wide speed ranges), a three-level, dual-phase inverter topology is presented in this paper. Its three-level attribute was based on the F-type inverter topological concept,...
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Integrated Photocatalytic Advanced Oxidation System (TiO2/UV/O3/H2O2) for Degradation of Volatile Organic Compounds
PublikacjaSeveral advanced oxidation processes (AOPs) including photocatalytic processes were studied for effective treatment of complex model wastewater containing a wide variety of VOCs. The studies revealed synergistic effects of TiO2 based processes for improved degradation of the VOCs. A peroxone combined with TiO2/UV system (TiO2/UV/O3/H2O2) with a ratio between the oxygen source from the oxidant to chemical oxygen demand (COD) of...
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Network Approach to Increments of RR-intervals for Visualization of Dynamics of Cardiac Regulation
PublikacjaThe transition network for RR -increments is pre- sented in a directed and weighted graph, with vertices represent- ing RR -increments and edges corresponding to the order in a sequence of increments. The adjacency matrix and the transition matrix of this network provide a graphical tool which could be useful in the assessment of cardiac regulation. As an example, the method is applied in detecting differences between diurnal activity...
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Possibilities of using SVC compensators for synchronous generators rotors oscillations damping.
PublikacjaThe article presents the idea of using static var compensators (SVC) for damping generators rotors oscillations. A novel SVC controller structure is proposed to provide better dynamic performance of the power system. A tests results are shown for proposed controller structure, that was carried out in a three-machine power system model as well as in multi-machine model of Polish Power System.
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Thermodynamics of solid phases containing rare earth oxides
PublikacjaRare earth elements (RE) are incorporated into a large variety of complex oxide phases to provide tailored mechanical, electrical, optical, and magnetic properties. Thermodynamics control phase stability, materials compatibility in use, corrosion, and transformation. This review presents, in one compilation, the thermodynamic properties of a large number of such materials and discusses systematic trends in energetics and the factors...
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Constructive entanglement test from triangle inequality
PublikacjaWe derive a simple lower bound on the geometric measure of entanglement for mixed quantum states in the case of a general multipartite system. The main ingredient of the presented derivation is the triangle inequality applied to the root infidelity distance in the space of density matrices. The obtained bound leads to entanglement criteria with a straightforward interpretation. The proposed criteria provide an experimentally accessible,...
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MULTIEQUATION MODELS AS DIAGNOSTIC TOOLS FOR MEASURING THE OPERATIONAL FLUIDITY OF THE CONTAINER HANDLING TERMINAL
PublikacjaThe article presents the continuation of the authors’ research on the problem of the operational fluidity of cargo handling sea terminals, based on the example of the DCT. The article presents a solution based on the multiequation models and applied to analyze the operational fluidity of terminals in the transshipment and feeder relation. To provide a solution to the problem of the functioning of sea-land supply chains at the terminal,...
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Optymalizacja wykorzystania energii hamowania - badania symulacyjne na przykładzie metra
PublikacjaPrzedstawiono metodykę i wyniki badań symulacyjnych wykorzystania energii hamowania odzyskowego w komunikacji miejskiej. Dla wybranego odcinka zasilania utworzono model sieci trakcyjnej wraz z podstacjami, a także modele poruszających się po tym odcinku pociągów, uwzględniając ich charakterystyki trakcyjne we wszystkich fazach ruchu oraz zmienne obciążenie, wynikające z pochylenia toru, profilu trasy i liczby pasażerów. Badano...
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Możliwości rozpoznawania zakłóceń układu obróbkowego na podstawie widma nierówności powierzchni obrobionej
PublikacjaW pracy przedstawiono oddziaływania układu obróbkowego na powierzchnię, które zakłócają odwzorowanie zarysu ostrza narzędzia w postaci jego przemieszczeń względnych do przedmiotu. Dla pełnej oceny i wartościowania zmian powierzchni posłużono się analizą amplitudowo-częstotliwościową nierówności profili poprzecznych powierzchni toczonych. Przedstawiono wyniki symulowania promieniowych i osiowych oddziaływań układu obrabiarki na...
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Ocena stanu przygotowania zawodowego studentów na podstawie praktyk studenckich
PublikacjaW referacie przedstawiono uwagi poczynione w toku ponad 8 letnich obserwacji stopnia przygotowania studentów do samodzielnej pracy po zakończeniu studiów na podstawie obserwacji poczynionych podczas praktyk studenckich. Dotyczą one w głównej mierze zaobserwowanych braków w wyrobieniu niektórych nawyków zawodowych jaki i niedopasowaniu profilu kształcenia zawodowego do bieżących oczekiwań firmy. Równocześnie należy nadmienić obecnie...
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Płeć a perspektywa zatrudnienia po ukończeniu uczelni technicznej - lata 2012-2016
PublikacjaKwestia kształcenia na poziomie szkolnictwa wyższego w kontekście zapotrzebowania i wymagań rynku pracy stanowi niezwykle istotny problem analiz teoretycznych, jak i empirycznych. Celem artykułu jest analiza sytuacji zawodowej osób, które ukończyły uczelnię o profilu technicznym. Kluczową zmienną braną pod uwagę w toku analiz porównawczych stanowi płeć. Dane empiryczne pozyskano w rezultacie badania sondażowego metodą CAWI, wśród...
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Looking for Social Enterprise Models in Poland: institutional and historical context
PublikacjaThe paper is an attempt at identification of key social enterprise models in Poland. The authors recognize three models: entrepreneurial non-profit organizations, cooperatives as well as social integration clubs and centres. Their social and institutional background is presented together with institutional trajectories of social enterprise development.
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Route vertical alignment design in the process of its regulation
PublikacjaW monografii przedstawiona została metoda opracowania projektu niwelety toru kolejowego na podstawie pomierzonych nierówności pionowych oraz praktyczny przykład jej zastosowania w procesie utrzymaniu dróg szynowych, a w szczególności w projektowaniu robót związanych z regulacją osi toru. Wykonany w ten sposób profil istniejącej linii kolejowej jest podstawą do obliczenia wartości podnoszeń toru. Wartości te nanosi się w terenie...
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Antioxidants and proteins in ethylene-treated kiwifruits
PublikacjaW pracy porównano właściwości przeciwutleniające i profil białek owoców kiwi poddanych działaniu etylenu i powietrza. Wysokie współczynniki korelacji między całkowitą zawartością fenoli i właściwościami przeciwutleniającymi uzyskano dla trzech metod określania właściwości przeciwutleniających: ABTS, TEAC i CUPRAC. W paśmie białek owoców kiwi rozdzielonych za pomocą elektroforezy stwierdzono różnice w paśmie siarczanu dodecylu sodu...
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Modele farmy wiatrowej na potrzeby prognozowania mocy
PublikacjaKrótkookresowe (z horyzontem 24-48 h) prognozowanie mocy farmy wiatrowej wymaga adekwatnego modelu uwzględniającego nie tylko wiatr (prędkość i kierunek) jako wymuszenie, ale także inne czynniki jak m.in.: właściwości i układ sterowania elektrowni wiatrowej, przesłonięcie, temperatura, profil pionowy, dynamika wiatru. Modele można podzielić na: fizykalne, statystyczne i behawioralne. W artykule przedstawiono wybrane modele mocy...
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RF Input-Quasi-Reflectionless Dispersive-Delay Structures Based on Complementary-Diplexer Circuits
PublikacjaA class of RF dispersive-delay structures (DDSs) with input-quasi-reflectionless behavior is reported. It is based on the exploitation of complementary-diplexer circuit networks, in which the out-of-band RF-input-power echoes reflected by the main bandpass-filter-(BPF)-type channel are dissipated by the resistively-terminated auxiliary bandstop-filter-(BSF)-type channel. Specifically, it is shown that the influence of the absorptive...
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Gelatin-Modified Polyurethanes for Soft Tissue Scaffold
PublikacjaRecently, in the field of biomaterials, which are being designed for soft tissue scaffolding, is growing the interest of their modification with natural polymers. Synthetic polymers are often hard, not easy to process and they do not possess fine biodegradable profile. From the other hand natural polymers are biocompatible, but weak when used alone. The combination of natural and synthetic polymers gives the suitable properties...
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The influence of dynamic load changes on temporary impedance in hydrogen fuel cells, selection and validation of the electrical equivalent circuit
PublikacjaTo achieve optimal performance of a fuel cell, a reliable monitoring and diagnostic method is required. The currently utilized methods give limited information or they are impossible to use under dynamic working conditions. To obtain comprehensive information about the fuel cell operation we utilized novel dynamic electrochemical impedance spectroscopy. Impedance measurements in dynamic mode were performed on a hydrogen fuel cell,...
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A numerical analysis of the thermal effects in the jet impingement stagnation zone
PublikacjaMost of the flows occurring in the engineering systems are turbulent and their accurate numerical analysis is still challenging, especially when combined with the heat transfer. One of the methods of heat transfer enhancement is utilization of the turbulent impinging jets, which were recently applied also in the heat exchangers. Their positive impact on the heat transfer performance was proven, but many questions related to its...
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Estimating the uncertainty of discharge coefficient predicted for oblique side weir using Monte Carlo method
PublikacjaSide weir is a hydraulic structure, which is used in irrigation systems to divert some water from main to side channel. It is installed at the entrance of the side channel to control and measure passing water into the side channel. Many studies provided side weir water surface profile and coefficient of discharge to measure water discharge diverted into the side channel. These studies dealt with different side weir shapes (rectangular,...
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Genetic and Epigenetic Aspects of Atopic Dermatitis
PublikacjaAtopic dermatitis is a heterogeneous disease, in which the pathogenesis is associated with mutations in genes encoding epidermal structural proteins, barrier enzymes, and their inhibitors; the role of genes regulating innate and adaptive immune responses and environmental factors inducing the disease is also noted. Recent studies point to the key role of epigenetic changes in the development of the disease. Epigenetic modifications...