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Synthesis and antimicrobial activity of amino acid and peptide derivatives of mycophenolic acid
PublikacjaThe series of 16 novel amino acid and peptide mycophenolic acid (MPA) derivatives was obtained as potential antibacterial agents. Coupling of MPA with respective amines was optimized with condensing reagents such as EDCI/DMAP and T3P/TEA. Amino acid analogs were received both as methyl esters and also with the free carboxylic group. The biological activity of the products was tested on five references bacterial strains: Klebsiella...
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Crystallization kinetics study of dynamically vulcanized PA6/NBR/HNTs nanocomposites by nonisothermal differential scanning calorimetry
PublikacjaInvestigation of crystallization behavior and kinetics of thermoplastic elastomer nanocomposites was the subject of limited works because of complexities associated with semiexperimental modeling of such phenomenon in a system containing components having completely different behavior in the molten state. Nonisothermal crystallization kinetics of dynamically vulcanized PA6/NBR/HNTs thermoplastic elastomer nanocomposites was mathematically...
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The Impact of Information and Communication Technology on the Rise of Urban Social Movements in Poland
PublikacjaThe chapter examines the relationship between the use of Information and Communications Technology (ITC) and the emergence of social movements focused on urban agenda in Poland. The aim is to investigate how and to what extent a growing body of smaller activist groups use opportunities provided by the ITC to achieve their political objectives. The research results indicate that Web-based media have helped to raise the profile...
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The Impact of Information and Communications Technology on the Rise of Urban Social Movements in Poland
PublikacjaThe chapter examines the relationship between the use of Information and Communications Technology (ITC) and the emergence of social movements focused on urban agenda in Poland. The aim is to investigate how and to what extent a growing body of smaller activist groups use opportunities provided by the ITC to achieve their political objectives. The research results indicate that Web-based media have helped to raise the profile of...
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A Simulation Model for Risk and Pricing Competition in the Retail Lending Market
PublikacjaWe propose a simulation model of the retail lending market with two types of agents: borrowers searching for low interest rates and lenders competing through risk-based pricing. We show that individual banks observe adverse selection, even if every lender applies the same pricing strategy and a credit scoring model of comparable discrimination power. Additionally, the model justifies the reverse-S shape of the response rate curve....
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HDAC Inhibitors: Innovative Strategies for Their Design and Applications
PublikacjaHistone deacetylases (HDACs) are a large family of epigenetic metalloenzymes that are involved in gene transcription and regulation, cell proliferation, differentiation, migration, and death, as well as angiogenesis. Particularly, disorders of the HDACs expression are linked to the development of many types of cancer and neurodegenerative diseases, making them interesting molecular targets for the design of new efficient drugs...
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Design, synthesis and biological evaluation of novel N-phosphorylated and O-phosphorylated tacrine derivatives as potential drugs against Alzheimer’s disease
PublikacjaIn this work, we designed, synthesised and biologically investigated a novel series of 14N- and O-phosphorylated tacrine derivatives as potential anti-Alzheimer’s disease agents. In the reaction of 9-chlorotacrine and corresponding diamines/aminoalkylalcohol we obtained diamino and aminoalkylhydroxy tacrine derivatives. Next, the compounds were acid to give final products 6–13 and 16–21 that were characterised by 1H, 13 C, 31P...
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Systemy wieloagentowe w prognozowaniu inwestycyjnym w telekomunikacji
PublikacjaArtykuł przedstawia przykład zastosowania ekonomii obliczeniowej opartej na systemach wieloagentowych w prognozowaniu rozwoju rynku telekomunikacyjnego. Inteligentne agenty programowe reprezentujące wszystkich uczestników rynku telekomunikacyjnego, a więc klientów, operatorów i dostawców sprzętu, działając na bazie rozproszonej sztucznej inteligencji, wchodzą w równoległe lokalne interakcje, podejmując decyzje wypracowane w oparciu...
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Systemy wieloagentowe w prognozowaniu inwestycyjnym telekomunikacji.
PublikacjaArtykuł przedstawia przykład zastosowania ekonomii obliczeniowej opartej na systemach wieloagentowych w prognozowaniu rozwoju rynku telekomunikacyjnego.Inteligentne agenty programowe reprezentujące wszystkich uczestników rynku telekomunikacyjnego, a więc klientów, operatorów i dostawców sprzętu, działając na bazie rozproszonej sztucznej inteligencji, wchodzą w równoległe lokalne interakcje, podejmując decyzje wypracowane w...
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Monitoring uciążliwości zapachowej pochodzenia rafineryjno-bytowego w Aglomeracji Trójmiejskiej przy wykorzystaniu technologii elektronicznego nosa
ProjektyProjekt realizowany w Wydział Chemiczny zgodnie z porozumieniem PBS2/B2/24/2013 z dnia 2013-12-13
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CONE Miasta oparte na naturze: rozwiązania Nature Based Solutions w miejskich laboratoriach
ProjektyProjekt realizowany w Katedra Technologii w Inżynierii Środowiska
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Model otwartej architektury rozproszonych dokumentów elektronicznych wspierającej proces podejmowania decyzji w trybie obliczeń zespołowych
PublikacjaModel otwartej architektury mobilnych dokumentów interaktywnych MIND, został opracowany w celu efektywnego zarządzania informacją w procesach podejmowanych przez organizacje oparte na wiedzy. Architektura ta stanowi całościowy opis struktury i funkcjonalności dokumentu, zaprojektowanego w celu realizacji rozproszonego przetwarzania zespołowego i pracy grupowej. Umożliwia automatyczne przejście od statycznej postaci dokumentów...
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Koncepcja platformy wymiany informacji o incydentach cyberbezpieczeństwa dla krajowego systemu elektroenergetycznego
PublikacjaArtykuł opisuje wybrane zagadnienia związane z cyberbezpieczeństwem w sektorze elektroenergetyki. Jednym z elementów zapewniania bezpieczeństwa sieci elektro-energetycznej jest efektywna wymiana informacji o incydentach bezpieczeństwa. W jej ramach wszystkie zaangażowane podmioty systemu elektroenergetycznego, tj.: elektrownie, operatorzy systemów przesyłowych, operatorzy systemów dystrybucyjnych, dostawcy rozwiązań bezpieczeństwa,...
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Activated Carbon Produced by Pyrolysis of Waste Wood and Straw for PotentialWastewater Adsorption
PublikacjaPyrolysis of straw pellets and wood strips was performed in a fixed bed reactor. The chars, solid products of thermal degradation, were used as potential materials for activated carbon production. Chemical and physical activation processes were used to compare properties of the products. The chemical activation agent KOH was chosen and the physical activation was conducted with steam and carbon dioxide as oxidising gases. The eect...
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Rapid Assays for Specific Detection of Fungi of Scopulariopsis and Microascus Genera and Scopulariopsis brevicaulis Species
PublikacjaPurpose Fungi of Scopulariopsis and Microascus genera cause a wide range of infections, with S. brevicaulis being the most prevalent aetiological agent of mould onychomycosis. Proper identification of these pathogens requires sporulating culture, which considerably delays the diagnosis. So far, sequencing of rDNA regions of clinical isolates has produced ambiguous results due to the lack of reference sequences in publicly available...
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Influence of CeO2 and TiO2 Particles on Physicochemical Properties of Composite Nickel Coatings Electrodeposited at Ambient Temperature
PublikacjaThe Ni-TiO2 and Ni-CeO2 composite coatings with varying hydrophilic/hydrophobic characteristics were fabricated by the electrodeposition method from a tartrate electrolyte at ambient temperature. To meet the requirements of tight regulation by the European Chemicals Agency classifying H3BO3 as a substance of very high concern, Rochelle salt was utilized as a buffer solution instead. The novelty of this study was to implement a...
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In vivo imaging of the human eye using a two-photon excited fluorescence scanning laser ophthalmoscope
PublikacjaBACKGROUND. Noninvasive assessment of metabolic processes that sustain regeneration of human retinal visual pigments (visual cycle) is essential to improve ophthalmic diagnostics and to accelerate development of new treatments to counter retinal diseases. Fluorescent vitamin A derivatives, which are the chemical intermediates of these processes, are highly sensitive to UV light; thus, safe analyses of these processes in humans...
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Instructor Presence in Video Lectures: Preliminary Findings From an Online Experiment
PublikacjaMotivation. Despite the widespread use of video lectures in online and blended learning environments, there is still debate whether the presence of an instructor in the video helps or hinders learning. According to social agency theory, seeing the instructor makes learners believe that s/he is personally teaching them, which leads to deeper cognitive processing and, in turn, better learning outcomes. Conversely, according to cognitive...
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Introducing concurrent engineering to space and satellite technology undergraduate course
PublikacjaIn recent decade concurrent engineering has become a de facto leading methodology of work in space, aeronautics and sometimes even automotive industry. It has been used in designing ESA space missions for 20 years now, with rst Concurrent Design Facility (CDF) built in ESTEC in 1998. Still, it has not become a universal standard in engineering, and universities are specically reluctant to adopt it into their curricula. As a result,...
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Pilicides effectively hinder chaperone-usher interactions in all Gram-negative bacteria
PublikacjaThe chaperone-usher pathway of adhesive structures biogenesis is highly conserved in all Gram-negative bacteria. Pili are polymers of thousands protein subunits that possess conserved immunoglobuline-like structure denoted by lack of the seventh G strand. The effect of this structural defect is a hydrophobic acceptor cleft. The folding of protein subunits is strictly dependent on the action of specific periplasmic chaperone protein...
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Wpływ smarowności na działania układu tribologicznego (impact of lubricity on the tribological system action)
Publikacjathe paper presents analysis and evaluation, based on tests results, of the impact of lubricity of the used lubricating oils (shell argina t 40) on the action of boundary layer of sulzer 6zl40/48 engines aboard the ''włocławek'' sea-going ship. for comparison purposes, the same oils were tested with the ceramizer four-stroke engine (all types of the vidar four-stroke engines) regeneration agent added. so understood boundary layer...
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Study on population dynamics for triple-linked food chain using a simulation-based approach
PublikacjaThe procedures based on simulation have become a feasible testing method that does not require investing valuable resources to create a concrete prototype, especially with the increasing computational power of computers. Thus, design changes can be adopted and design errors can be fixed before it is too late. Simulation turns to be a cheap, safe and often more acceptable from an ethical perspective. In our work we summarize the...
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How Chain Transfer Leads to a Uniform Polymer Particle Morphology and Prevents Reactor Fouling
PublikacjaABSTRACT: The effect of adding diethyl zinc as a chain transfer agent during the polymerization of propylene in heptane performed at 80 °C was studied. Although it was expected that the chain transfer would stop after precipitation of the polymer, the polymer molecular weight continued to increase throughout the whole of the polymerization. The presence of diethyl zinc had an additional effect that the polymerizations were devoid...
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Approach to security assessment of critical infrastructures' information systems
PublikacjaThis study presents an approach to the security assessment of the information systems of critical infrastructures. The approach is based on the faithful reconstruction of the evaluated information system in a computer security laboratory followed by simulations of possible threats against the system. The evidence collected during the experiments, stored and organised using a proprietary system InSAW, may later be used for the creation...
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Fake VIP Attacks and Their Mitigation via Double-Blind Reputation
PublikacjaIn a generic setting subsuming communication networks, resource sharing systems, and multi-agent communities, a client generates objects of various classes carrying class-dependent signatures, to which a server assigns class-dependent service quality. A Fake VIP attack consists in false declaration of a high class, with an awareness that detection of object signature at the server side is costly and so invoked reluctantly. We show...
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Comparative molecular modelling of biologically active sterols
PublikacjaMembrane sterols are targets for a clinically important antifungal agent – amphotericin B. The relatively specific antifungal action of the drug is based on a stronger interaction of amphotericin B with fungal ergosterol than with mammalian cholesterol. Conformational space occupied by six sterols has been defined using the molecular dynamics method to establish if the conformational features correspond to the preferential interaction...
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Cognitum Ontorion: Knowledge Representation and Reasoning System
Publikacja“If knowledge can create problems, it is not through ignorance that we can solve them.” (Isaac Asimov). Nevertheless, at any point of human activity, knowledge (besides practice) is a key factor in understanding and solving any given problem. Nowadays, computer systems have the ability to support their users in an efficient and reliable way. In this paper we present and describe the functionality of the Cognitum Ontorion system....
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Deep eutectic solvents based assay for extraction and determination of zinc in fish and eel samples using FAAS
PublikacjaA new assay based on effective (high recovery) extraction by means of deep eutectic solvents (DESs) was developed for ppb level determination of zinc in fishes and eel samples. Choline chloride and Phenol in a 1:2 M ratio was selected as optimal DES-based extraction solvent. 8-Hydroxy quinoline was used as a chelating agent for zinc ions. The optimized conditions were found at pH value of 8, ligand concentration of 10 mg/L, THF...
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DESIGN AND THEORETICAL ANALYSIS OF A PROTOTYPE TILTING-PAD RADIAL BEARING WITH ADJUSTABLE CLEARANCE
PublikacjaThe article introduces a design and analysis results of a prototype ORC (organic Rankine cycle) turbo generator rotor assembly of 300kW power, supported by tilting-pad bearings of original design. The calculations were performed for a prototype turbo generator rotor. The shaft of this machine is supported with two radial bearings, lubricated with an unusual lubricant – a low-boiling-point agent. The main objective of the presented...
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Hybrid use of the building as a method supporting epidemic safety
PublikacjaThe COVID-19 pandemic has resulted in changing organisational and technical requirements in the operation of treatment facilities. This paper summarises the available knowledge on the principles of hybrid design of the architecture of treatment units to ensure that different levels of sanitary and hygienic safeguards can be implemented. The basis of this narrative overview is an analysis of the existing Polish legislation on required...
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Parametric versus nonparametric modelling of dynamic susceptibility contrast enhanced MRI based data
PublikacjaDynamic tracking of a bolus of a paramagnetic agent (dynamic susceptibility contract - DSC) in MRI (magnetic resonance imaging) measurements is successfully used for assessment of the tissue perfusion and the other features and functions of the brain (i.e. cerebral blood flow - CBF, cerebral blood volume - CBV, mean transit time - MTT). The parametric and nonparametric approaches to the identification of MRI models are presented...
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Ocena jakości powietrza atmosferycznego na terenie Aglomeracji Trojmiejskiej = Quality of atmospheric air in the Tricity area
PublikacjaNa terenie Aglomeracji Trójmiejskiej i Tczewa monitoring jakości powietrza prowadzony jest, obok jednostek samorządowych przez fundację: Agencja Monitoringu Regionalnego Atmosfery Aglomeracji Gdańskiej - ARMAAG. Katedra Chemii Analitycznej PG współpracując z fundacją ARMAAG podjęła próbę uzupełnienia informacji na temat stanu atmosfery na terenie Trójmiasta i Tczewa o ocenę pod względem zawartości analitów z grupy BTEX. Celem...
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Using human behavior to develop knowledge-based virtual organisations
PublikacjaPropozycja modelu opartego na zachowaniach ludzkich dla potrzeb budowy wirtuanych organizacji opartych na wiedzy.Virtual organizations promote dynamic interaction between individuals, groups, and organizations, who share their capabilities and resources to pursue a common goal and maximize their benefits. Among these resources, knowledge is a critical one that requires special attention in order to support problem-solving activities...
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Optimized 5-hour multiplex PCR test for the detection of tinea unguium: performance in a routine PCR laboratory
PublikacjaWe recently reported the development of a 5-hour multiplex PCR test for the detection of tinea unguium and the optimization of this test by the inclusion of an inhibition control. Here we report the performance of this procedure as used in a routine clinical laboratory as compared to conventional microscopy and culture-based techniques performed in a mycology reference laboratory. We found in processing 109 samples that 22 (20.2%)...
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Gold nanoparticles evaluation using functional optical coherence tomography
PublikacjaThe main object of this research was to assess the ability to characterize the gold nanoparticles using optical modalities like optical coherence tomography. Since the nanoparticles, especially gold one, have been very attractive for medical diagnosis and treatment the amount of research activities have been growing rapidly. The nanoparticles designed for different applications like contrast agents or drugs delivery change the...
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Alternative Methods of Preparation of Soluble Keratin from Chicken Feathers
PublikacjaHuge amount of keratinous waste, especially birds’ feathers, demands more value-added application instead of dumping. The present work reports the results of experiments aimed at preparing soluble keratin useful for novel bioproduct formation. The effect of thermo-chemical treatments with various reducing agents, i.e. 2-mercaptoethanol, dithiothreitol, sodium m-bisulphite, and sodium bisulphite, as well as sodium hydroxide, on...
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Oferta instytucji otoczenia biznesu w Polsce
PublikacjaPrezentowany rozdział poświęcony jest analizie sektora otoczenia biznesu w Polsce. Autorka, bazując na dostępnych statystykach i raportach z badań przedstawia ofertę, zakres realizowanych działań oraz potencjał ludzki, techniczny i finansowy poszczególnych typów instytucji okołobiznesowych: ośrodków innowacji (w tym struktur parkowych, inkubatorów i centrów transferu technologii), ośrodków przedsiębiorczości (przede wszystkim ośrodków...
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Missing Puzzle Pieces in Dementia Research: HCN Channels and Theta Oscillations
PublikacjaIncreasing evidence indicates a role of hyperpolarization activated cation (HCN) channels in controlling the resting membrane potential, pacemaker activity, memory formation, sleep, and arousal. Their disfunction may be associated with the development of epilepsy and age-related memory decline. Neuronal hyperexcitability involved in epileptogenesis and EEG desynchronization occur in the course of dementia in human Alzheimer’s Disease...
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Fabrication of wormhole-like YSZ and Ni-YSZ by the novel soft-hard template CTAB/NaCl-assisted route. Suppressing Ni coalescence in SOFC
PublikacjaA novel one-pot synthesis route leading to the formation of a wormhole-like structure was developed for the successful fabrication of porous YSZ and Ni-YSZ systems. This method involved co-precipitation in the presence of the micelle-forming agents CTAB/Pluronic P123 and crystallising NaCl. The obtained skeletons were mechanically stable and presented almost 50% uniform, open porosity without using any additional pore-formers....
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The implementation of green transformation through clusters
PublikacjaThe paper addresses a poorly documented issue in the literature, namely the role of clusters in green transformation, including processes related to green, low-carbon, and circular economies. The purpose was to identify and understand the practices of clusters in this area. The adopted mixed research strategy consisted of both qualitative and quantitative research. Both research phases were conducted in a group of Polish Key National...
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Ultrasound assisted synthesis of 3-alkynyl substituted 2-chloroquinoxaline derivatives: Their in silico assessment as potential ligands for N-protein of SARS-CoV-2
PublikacjaIn view of recent global pandemic the 3-alkynyl substituted 2-chloroquinoxaline framework has been explored as a potential template for the design of molecules targeting COVID-19. Initial in silico studies of representative compounds to assess their binding affinities via docking into the N-terminal RNA-binding domain (NTD) of N-protein of SARS-CoV-2 prompted further study of these molecules. Thus building of a small library of...
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Transport of paracetamol in swellable and relaxing polyurethane nanocomposite hydrogels
PublikacjaPolyurethane hydrogels are potentially attractive materials for biomedical applications. They are able to absorb large amount of water, biological fluids or active substances, and thus, they have potential to be used as absorbents or wound-healing dressings. They are also used for the controlled release of therapeutics because of their capacity to embed biologically active agents in their water-swollen network. The presence of...
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BIS Bałtycka symbioza przemysłowa
ProjektyProjekt realizowany w Katedra Inżynierii Procesowej i Technologii Chemicznej z dnia 2020-01-30
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Nanocrystalline diamond sheets as protective coatings for fiber-optic measurement head
PublikacjaFiber-optic sensors find numerous applications in science and industry, but their full potential is limited because of the risk of damaging the measurement head, in particular, due to the vulnerability of unprotected tips of the fiber to mechanical damage and aggressive chemical agents. In this paper, we report the first use of a new nanocrystalline diamond structure in a fiber-optic measurement head as a protective coating of...
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Modelling of heat transfer in supercritical pressure recuperators
PublikacjaIn the paper presented is analysis of convective flow heat transfer at supercritical pressure in channels of heat exchanger working in the thermodynamic cycle. The modelling is based on the division of the flow into three regions, namely the heavy fluid, a two phase flow consisting of the heavy and light fluids and finally the light fluid flow. Modelling is concentrated on the region of simultaneous flow of two fluids divided into...
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Analytics of Surfactants in the Environment: Problems and Challenges
PublikacjaSurfactants (surface active agents = SAAs) are a group of compoundswith specific physicochemical properties (amphiphilicity,solubility in polar and nonpolar liquids, ability to form micelles,adsorption at phase boundaries).1,2 Because of their properties,surface-active compounds are widely applied in industry and thehousehold (e.g., in detergents, personal-care products, paints,pesticides, petroleum products). As their applications...
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Anticarcinogenic and antioxidant activities of leaves and flowers hydroalcoholic extracts of Nerium oleander L.: PCA analysis and phytochemical content by FTIR spectroscopy
PublikacjaAims: The aim of this work is the evaluation the anticarcinogenic effect on HT29 cancer cells lines and antioxidant effect of three extracts from different morphological parts (leaves (LE), pink flowers (PFE) and white flowers (WFE)) of Nerium oleander lin. Methods: This research provides the anticarcinogenic activity of extracts from N. oleander white flowers. Principal Component Analysis (PCA) was applied to estimate the relationship...
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Use of Escherichia coli Nissle 1917 producing recombinant colicins for treatment of IBD patients
PublikacjaPatients with Crohn’s Disease and ulcerative colitis infected with Adherent-Invasive Escherichia coli strains constitute the largest group among Inflammatory Bowel Disease subjects, when taking into account all known etiological agents of the disease. A possible link between these pathogenic bacteria and inflammation process has gained the confidence in recently published papers. Observed enteric neuroglial cells apoptosis and...
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Tetrahydroquinolinone derivatives exert antiproliferative effect on lung cancer cells through apoptosis induction
PublikacjaThe anticancer properties of quinolones is a topic of interest among researchers in the scientific world. Because these compounds do not cause side effects, unlike the commonly used cytostatics, they are considered a promising source of new anticancer drugs. In this work, we designed a brief synthetic pathway and obtained a series of novel 8-phenyltetrahydroquinolinone derivatives functionalized with benzyl-type moieties at position...
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Morphology control through the synthesis of metal-organic frameworks
PublikacjaDesignable morphology and predictable properties are the most challenging goals in material engineering. Features such as shape, size, porosity, agglomeration ratio significantly affect the final properties of metal- organic frameworks (MOFs) and can be regulated throughout synthesis parameters but require a deep under- standing of the mechanisms of MOFs formation. Herein, we systematically summarize the effects of the indi- vidual...