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Search results for: controlled drug delivery
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Neuroprotective Effects of Cannabidiol in Hypoxic Ischemic Insult. The Therapeutic Window in Newborn Mice
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DEVELOPMENT OF HYDROGEL CAPSULES FOR USE IN DUAL-PHASE TOPICAL PREPARATIONS CONTAINING DIHYDROXYACETONE AND AMINO ACIDS – PRELIMINARY RESULTS
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ASSESSMENT OF SAFETY OF PAIN CONTROL BY NON-OPIOID OVER-THE COUNTER MEDICATIONS
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THE USE OF OTC HERBAL SEDATIVES BY PHARMACY PATIENTS – A QUESTIONNAIRES-BASED SURVEY STUDY
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In vitro dissolution test of ketoprofene: development and evaluation of release from soft and hard gelatine capsules
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Evaluation of Chemotherapeutic Activity of the Selected Bases’ Analogues of Nucleic Acids Supported by ab initio Various Quantum Chemical Calculations
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Legal and economic identification and assessment of pharmacy substitution in narrow therapeutic index drugs, on the example of epileptic medications in Poland
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A policy view: gaps and weaknesses of substitution between biological products in law and economics dimension: the example of insulin
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CHROMATOGRAPHIC TECHNIQUES IN PHARMACEUTICAL ANALYSIS IN POLAND: HISTORY AND THE PRESENCE ON THE BASIS OF PAPERS PUBLISHED IN SELECTED POLISH PHARMACEUTICAL JOURNALS IN XX CENTURY
PublicationFor a long time, chromatographic techniques and techniques related to them have stimulated the development of new procedures in the field of pharmaceutical analysis. The newly developed methods, characterized by improved metrological parameters, allow for more accurate testing of, among others, the composition of raw materials, intermediates and final products. The chromatographic techniques also enable studies on waste generated...
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FLUID BED COATING OF MINITABLETS AND PELLETS WITH OPTIMIZATION OF THE PROCESS BASED ON TAGUCHI METHOD
PublicationSmall particles like pellets are coated in fluid bed systems. This method can be also feasible for minitablets but the selection of optimal process parameters is complicated. The aim of the research was to optimize the coating process for minitablets and to compare the conditions required for pellets. Minimum fluidization velocities (umf) for 2.0 and 2.5 mm minitablets and 0.7-0.8 mm or 1.0-1.25 mm pellets were determined experimentally....
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Self-Testing of Analog Parts Terminated by ADCs Based on Multiple Sampling of Time Responses
PublicationA new approach for self-testing of analog parts terminated by analog-to-digital converters in mixed-signal electronic microsystems controlled by microcontrollers is presented. It is based upon a new fault diagnosis method using a transformation of the set of voltage samples of the time response of a tested analog part to a square impulse into localization curves placed in a multidimensional measurement space. The method can be used...
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Optimizing control by robustly feasible model predictive control and application to drinking water distribution systems
PublicationThe paper considers optimizing Model Predictive Control (MPC) for nonlinear plants with output constraints under uncertainties. Although the MPC technology can handle the constraints in the model by solving constraint model based optimization task, satisfying the plant output constraints under the model uncertainty still remains a challenge. The paper proposes Robustly Feasible MPC (RFMPC), which achieves feasibility of the outputs...
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Low temperature deposition of dense MnCo 2 O 4 protective coatings for steel interconnects of solid oxide cells
PublicationIn this work manganese cobalt spinel (MnCo2O4) coatings were deposited on steel substrates by spray pyrolysis at 390 °C. This is at much lower temperatures than previously reported (typically in excess of 900 °C). It was possible to produce coatings with well controlled thickness (2-5-10 μm). The as-deposited coatings were evaluated for their microstructural changes and electrical conductivity up to 800 °C. Results confirm the...
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Influence of Heat Treatment Temperature on Fatigue Toughness in Medium-Carbon High-Strength Steels
PublicationCurrent research has demonstrated that the tempering temperature affects the martensitic transformation of medium-carbon high-strength steels. This temperature plays an important role in the final microstructure, percentage ratios of martensite to ferrite phases and, consequently, in the mechanical properties and the fatigue response. So far, the relationship between the martensitic tempering temperature and the cyclic deformation...
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Preliminary study of linear viscoelasticity limits of cold recycled mixtures determined in Simple Performance Tester (SPT)
PublicationThe publication presents methodology developed for determination of linear viscoelasticity limits for cold recycled mixtures with cement and bituminous emulsion using Simple Performance Tester (SPT). Methodology was verified on reference materials (PCV and steel dummy specimens, cement concrete and asphalt concrete) to comply with elasticity and viscoelasticity theory. The developed methodology enabled determination of linear viscoelasticity...
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Chitosan, Collagen and Gelatin in the design of novel materials with antimicrobial acticity
PublicationMedical devices containing and releasing antiinfective agents directly on the site of injury are a common group of materials available and widely used in treating difficult to heal wounds. Sustained contact of the active agent to the damaged tissue, needed to inhibit infection and preservation of microbiological purity of the wound, is provided by the immobilization antimicrobial agents on the surface of the matrix material or...
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Enhanced hydrogen evolution reaction on highly stable titania-supported PdO and Eu2O3 nanocomposites in a strong alkaline solution
PublicationIn this work, PdO/TiO2 and Eu2O3/TiO2 nanocomposites (NCs), were synthesized using a new facile, template-free and one-step solvothermal approach, and characterized by several instrumentation techniques. X-ray photoelectron spectroscopy (XPS) studies revealed the presence of oxidised form of the Pd and Eu nanoparticles within the nanocomposite materials (PdO and Eu2O3). The two catalysts exhibited remarkable activity for the HER...
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Chitosan-based electrospun nanofibers for encapsulating food bioactive ingredients: A review
PublicationToday, society has been more aware of healthy food products and related items containing bioactive compounds, which potentially contribute to human health. Unfortunately, the long-term stability and bioactivity of biologically active compounds against environmental factors compromise their target and effective action. In this way, lab-designed vehicles, such as nanoparticles and nanofibers, provide enough properties for their preservation...
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A framework of open government data (OGD) e-service quality dimensions with future research agenda
PublicationPurpose This research paper aims to present a framework of open government data (OGD) relating to e-service quality dimensions. In addition, it provides a research agenda for the e-service delivery of OGD. Design/methodology/approach A literature review pertaining to e-service quality with special reference to e-government was delivered to deduce the key dimensions of e-service quality for OGD. Findings Five e-service quality dimensions...
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Influence of Parameters of Laser Beam Welding on Structure of 2205 Duplex Stainless Steel
PublicationLaser welding is used in modern industry, having many advantages comparing to traditional welding technologies. Nowadays, industry sectors such as shipbuilding, automotive and aviation can’t be imagined without laser processing technologies. Possibility of increase of welded joint properties, autogenous welding and high level of process automation makes the technology of laser welding perspective part of the industry. Physical...
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Wpływ ścieków przemysłowych na energochłonność i efektywność procesów technologicznych w komunalnej oczyszczalni ścieków
PublicationW artykule skupiono się na przedstawieniu wpływu jakości i ilości ścieków przemysłowych wprowadzanych do sieci kanalizacyjnej PEWIK GDYNIA Sp. z o. o. na stabilność procesów technologicznych. Określono również wpływ ścieków przemysłowych na energochłonność i efektywność oraz na wzrost kosztów oczyszczania ścieków komunalnych w Grupowej Oczyszczalni Ścieków „Dębogórze” w latach 2012-2015.
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Postawy osób starszych wobec tradycyjnych i innowacyjnych kanałów dystrybucji usług finansowych
PublicationRosnący udział osób starszych w strukturze populacji stawia nowe wyzwania przed przedsiębiorstwami oferującymi produkty do nich skierowane. Przykładem takich produktów są usługi finansowe. Przedmiotem niniejszego tekstu są usługi ubezpieczeniowe i bankowe oferowane osobom starszym z wykorzystaniem tradycyjnych i nowoczesnych kanałów dystrybucji. Na podstawie przeglądu literatury sformułowano dwie hipotezy badawcze: H1: Cechy społeczno-demograficzne...
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Analiza wielokryterialna wariantów systemu zaopatrzenia w wodę zespołu padów
PublicationJednym z istotnych problemów decyzyjnych na etapie potencjalnej eksploatacji gazu z formacji łupkowych jest wybór sposobu zaopatrzenia w wodę kopalni gazu łupkowego. Z uwagi na duże zapotrzebowanie na wodę do procesu szczelinowania kolejno przekazywanych do eksploatacji odwiertów wydobywczych, należy poszukiwać systemu zaopatrzenia w wodę, który zagwarantuje wymaganą jej ilość, a jednocześnie nie będzie zbyt dużym obciążeniem dla...
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The Efficacious Benefit of 25-Hydroxy Vitamin D to Prevent COVID-19: An In-Silico Study Targeting SARS-CoV-2 Spike Protein
PublicationThe environment has rapidly looked at proven specialist task forces in the aftermath of the COVID-19 pandemic to build public health policies and measures to mitigate the effects of emerging coronaviruses. According to the researchers, taking 10 μg of 25-hydroxy vitamin D daily is recommended to keep us safe. There have been several studies recently indicating that there is a reduced risk of contracting Coronavirus by 25-hydroxy...
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Glucosinolates from lepidium peruvianum as potential antiamnestic drugs
PublicationLepidium peruvianum (maca) (Brassicaceae) is a naturally occurring plant mainly in the high Andes of Peru. In recent years, it has been intensively researched in terms of its influence on various diseases and towards health improvement. Alzheimer’s disease is an incurable disease that most often affects adults over the age of 60. As since 2003 the US Food and Drug Administration (FDA) did not approve any new drug for Alzheimer’s...
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The Use of Free Adjustment and Msplit-Estimation for Determination of the Vertical Displacements in Unstable Reference System
PublicationThe problem of the determining of the displacements of engineering objects and their surroundings is the current and important issue in the field of engineering geodesy. Most control measurements are made in relation to reference points (stable points). On the other hand, sometimes it happens that it is not possible perform the measurements with reference to the stable points or identification of stable points is difficult. Therefore,...
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Using an IEEE1149.1 Test Bus for Fault Diagnosis of Analog Parts of Electronic Embedded Systems
PublicationThe new solution of a BIST called the JTAG BIST for self-testing of analog parts of electronic embedded systems is presented in the paper. The JTAG BIST consists of the BCT8244A and SCANSTA476 integrated circuits of Texas Instruments controlled via the IEEE 1149.1 bus. The BCT8244A is a scan test device with octal buffers, and the SCANSTA476 is a 12-bit ADC with 8 analog input channels. Self-testing approach is based on the fault...
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Materiał węglowy ptrzymany na bazie karbonizowanego chitozanu domieszkowanego platyną = CARBON MATERIAL RECEIVED THROUGH CARBONIZATION OF CHITOSAN DOPED WITH PLATINUM
PublicationThe aim of this work was to investigate the impact of porous carbons with high nitrogen content onthe platinum catalyst performance properties. The system may be applied as well as cathodic catalyst for oxygenreduction in microbial fuel cells.We report a simple route for preparation of dispersed Platinum on the carbon support. Chitosan powder wasprotonated using aqueous solution of organic acid. The water from the pores was removed...
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Eye-Gaze Tracking-Based Telepresence System for Videoconferencing
PublicationAn approach to the teleimmersive videoconferencing system enhanced by the pan-tilt-zoom (PTZ) camera, controlled by the eye-gaze tracking system, is presented in this paper. An overview of the existing telepresence systems, especially dedicated to videoconferencing is included. The presented approach is based on the CyberEye eye-gaze tracking system engineered at the Multimedia Systems Department (MSD) of Gdańsk University of Technology...
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Sensorless Multiscalar Control of Five-Phase Induction Machine with Inverter Output Filter
PublicationThe paper presents a complete solution for speed sensorless control system for five-phase induction motor with voltage inverter, LC filter and nonlinear control of combined fundamental and third harmonic flux distribution. The control principle, also known as multiscalar control, nonlinear control or natural variables control, is based on a use of properly selected scalar variables in control feedback to linearize controlled system....
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The Creation of an Antimicrobial Coating on Contact Lenses by The Use of Nanocopper
PublicationThe aim of the research was to creation an antimicrobial coating on contact lens and examine the ability of copper nanoparticles to decrease microbial adhesion and prevent the growth of bacteria. The creation was based on the immersion method in solution with dispersed nanoparticles of copper at concentration 200 pm. There were evaluated follows factors: time of immersion and base to dispersed nanoparticles. Three solutions: ethyl...
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The distributed model predictive controller for the nuclear power plant turbo-generator set
PublicationTypically there are two main control loops with PI controllers operating at each turbo-generator set. In this paper a distributed model predictive controller DMPC, with local QDMC controllers for the turbine generator, is proposed instead of a typical PI controllers. The local QDMC controllers utilize step-response models for the controlled system components. These models parameters are determined based on the proposed black-box...
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THE INFLUENCE OF THE URBAN DESIGN ON THE AIR EXCHANGE IN CITIES. SELECTED PROBLEMS IN POLISH REALITY
PublicationThe progress of the architecture and urbanism raises problems requiring interdisciplinary research conducted with the use of advanced experimental techniques and computer simulation. The fields of this research include aerodynamics, especially in intensively developed area of Environmental Wind Engineering (EWE). Aerodynamic phenomena occurring around buildings have a significant impact on the quality of the climate in the cities....
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Analysis of wave propagation in a bolted steel joint
PublicationThe paper presents results of numerical and experimental investigations of elastic wave propagation in a bolted single-lap joint. The research was carried out for both symmetric and antisymmetric Lamb wave modes. In experimental studies the PZT transducers were used to excite and register wave propagation signals. The controlled value of the torque during measurements was ensured by the use of high precision torque wrenches. Numerical...
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SAMPLE-AND-HOLDING METHOD FOR GAS SENSING APPLIED FOR RESISTANCE GAS SENSORS
PublicationThe DC resistance of a Taguchi gas sensor is influenced by the ambient gas. To improve the selectivity and sensitivity of a sensor the fluctuation enhanced sensing (FES) was used. The paper proposes a novel methodology of utilizing FES technique that sample composition of an ambient atmosphere and hold it for further processing (sample-and-holding technique). The method uses the heated gas sensor to sample an ambient atmosphere...
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Robustness Analysis of a Distributed MPC Control System of a Turbo-Generator Set of a Nuclear Plant – Disturbance Issues
PublicationTypically, there are two main control loops with PI controllers operating at each turbo-generator set. In this paper, a distributed model predictive controller with local quadratic model predictive controllers for the turbine generator is proposed instead of a set of classical PI controllers. The local quadratic predictive controllers utilize step-response models for the controlled system components. The parameters of these models...
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Radiosensitization of DNA in presence of Pt(II)-based compounds
PublicationX-ray irradiation of plasmid DNA in presence of platinum (II)-based compounds was carried out in order to assess the radiosensitization capabilities of these drugs. In present investigations pBR322 plasmid DNA was used to monitor the effectiveness of chosen compounds in inducing strand breaks. Samples were incubated in the presence of potential radiosensitisers: platinum (II) bromide and cis-diamminedibromoplatinum (II). The results...
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Computational methods for calculation of binding free energy for ligand-receptor complexes
PublicationAccurate description of the molecular complexes energetic influence is required for understanding of many biological functions carried out by proteins. Therefore, estimation of binding free energy for ligand-receptor complexes is of highest importance for structure-based ligand design and drug discovery approaches.Experimental methods of determination of difference in Gibbs'es free energy have many limitations. Thus, computational...
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Synthesis and biological evaluation of novel analogues of batracylin with synthetic amino acids and adenosine: an unexpected effect on centromere segregation in tumor cells through a dual inhibition of topoisomerase IIa and Aurora B
PublicationIn the search for new anticancer agents we designed and synthesized batracylin derivatives with linking synthetic amino acid side chains of different lengths and adenosine. Unexpectedly, we have found that in water and the culture media adenosine–amino acid–BAT conjugates form supramolecular structures and this prevents these compounds from entering cells. Consequently, these compounds exerted no biological activity when tested...
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Recent progress in the development of steroid sulfatase inhibitors – examples of the novel and most promising compounds from the last decade
PublicationThe purpose of this review article is to provide an overview of recent achievements in the synthesis of novel steroid sulfatase (STS) inhibitors. STS is a crucial enzyme in the biosynthesis of active hormones (including estrogens and androgens) and, therefore, represents an extremely attractive molecular target for the development of hormone-dependent cancer therapies. The inhibition of STS may effectively reduce the availability...
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Inhibitors of glucosamine-6-phosphate synthase as potential antimicrobials or antidiabetics – synthesis and properties
PublicationGlucosamine-6-phosphate synthase (GlcN-6-P synthase) is known as a promising target for antimicrobial agents and antidiabetics. Several compounds of natural or synthetic origin have been identified as inhibitors of this enzyme. This set comprises highly selective L-glutamine, amino sugar phosphate or transition state intermediate cis-enolamine analogues. Relatively low antimicrobial activity of these inhibitors, poorly penetrating...
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Evaluating the position of a mobile robot using accelerometer data
PublicationThis paper analyses the problem of determining the position of a robot using an accelerometer, which is an essential part of inertial measurement units (IMU). The information gained from such a gauge, however, requires double integration of sensor data. To assure an expected effect, a mathematical model of a low-cost accelerometer of the MEMS type is derived. Moreover, in order to improve the performance of positioning based on...
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EXPERIMENTAL STUDY OF SURFACE ROUGHNESS EFFECT ONTHE RHEOLOGICAL BEHAVIOR OF MR FLUID
PublicationPaper presents the results of shear stress measurements of a commercial magnetorheological fluid using a plate-plate type geometry with a modified working surface. The purpose of the study was to determine the effect of changing the roughness of the measuring plate on the obtained shear stress results. Controlled shear rate tests and Magneto Sweep measurements were carried out for three MR fluid layer heights. The tests were...
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Improving Control Dynamics of PMSM Drive by Estimating Zero-Delay Current Value
PublicationDynamic performance of current control loop still remains crucial for position-, speed-, and torque-controlled drives. In the study, a current loop solution has been designed for field oriented control of permanent magnet synchronous motors (PMSM). It enhances typical PI controller with an estimator of zero-delay current (ZDC) value. The ZDC estimation allows for selecting substantially higher controller gain. It reduces control...
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Preliminary studies of seamless flux cored wires stored in extreme conditions
PublicationIn the paper preliminary experimental studies of flux cored wires moisturized under controlled conditions are described. Three seamless wires of different grades have been placed in environmental chamber and moisturized in extremely adverse conditions (temperature T = 60° C, relative humidity H = 90%) for 240 hours. During this time measurements of weight gain and observations of surface of wires have been carried out. Also diffusible...
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Database for integration of information in distributed data exchange system elements of Border Guard
PublicationThe paper presents the database solution for integration of information in distributed data exchange system elements of the Polish Border Guard. The proposed database solution is described in the context of data exchange system elements which control position and store identification data of vessels (fishing, sports and sailing boats) and other suspicious objects on the territorial sea, sea-coast and the internal sea-waters controlled...
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Evaluating the mobile robot positions using accelerometer data
PublicationThis paper analyzes the problem of determining the position of a robot using an accelerometer, which is an essential part of inertial measurement units (IMU). The information gained from such a gauge, however, requires double integration of sensor data. To assure an expected effect, a mathematical model of a low-cost accelerometer of the MEMS type is derived. Moreover, in order to improve the performance of positioning based on...
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Analysis of the Application of Horizontal Directional Drilling
PublicationConstruction works are often considered to be very intrusive for the environment. Project designers assume deep excavations, or a complete replacement of the ground within the investment, which sometimes changes the initial conditions drastically. The problem started to appear in places, where the terrain is complicated and the excavation is burdensome. Some of state authorities...
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Different Ways to Apply a Measurement Instrument of E-Nose Type to Evaluate Ambient Air Quality with Respect to Odour Nuisance in a Vicinity of Municipal Processing Plants
PublicationThis review paper presents different ways to apply a measurement instrument of e-nose type to evaluate ambient air with respect to detection of the odorants characterized by unpleasant odour in a vicinity of municipal processing plants. An emphasis was put on the following applications of the electronic nose instruments: monitoring networks, remote controlled robots and drones as well as portable devices. Moreover, this paper presents...
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Methodology of Selecting the Optimal Receptor to Create an Electrochemical Immunosensor for Equine Arteritis Virus Protein Detection
PublicationThe study reports a methodology of selecting the optimal receptor to create an electrochemical immunosensor for equine arteritis virus (EAV) protein detection. The detection was based on antigen recognition by antibodies immobilized on gold electrodes. Modification steps were controlled by electrochemical impedance spectroscopy and cyclic voltammetry measurements. In order to obtain the impedance immunosensor with the best parameters,...