Filters
total: 6262
filtered: 3666
-
Catalog
- Publications 3666 available results
- Journals 51 available results
- Conferences 1 available results
- People 77 available results
- Inventions 5 available results
- Projects 6 available results
- Laboratories 2 available results
- Research Equipment 1 available results
- e-Learning Courses 405 available results
- Events 11 available results
- Open Research Data 2037 available results
Chosen catalog filters
displaying 1000 best results Help
Search results for: A-C:H FILMS
-
A general approach to continuous time Gm-C filters.
PublicationW pracy zaproponowano ogólną strukturę filtrów Gm-C z odpowiednim opisem macierzowym. W odniesieniu do tej struktury podano formuły analizy wrażliwościowej dla dowolnego filtru Gm-C czasu ciągłego. Analiza oparta na opisie macierzowym była wykorzystana również do porównania właściwości filtrów Gm-Ctrybu napięciowego i prądowego. Zdefiniowano dwie kanoniczne transformacje dla klasy filtrów zmiennych stanu.
-
Role of Human UDP-Glucuronosyltransferases in the Biotransformation of the Triazoloacridinone and Imidazoacridinone Antitumor Agents C-1305 and C-1311 : Highly Selective Substrates for UGT1A10
Publication5-Diethylaminoethylamino-8-hydroxyimidazoacridinone, C-1311 (NSC-645809), is an antitumor agent shown to be effective against breast cancer in phase II clinical trials. A similar compound, 5-dimethylaminopropylamino-8-hydroxytriazoloacridinone, C-1305, shows high activity against experimental tumors and is expected to have even more beneficial pharmacological properties than C-1311. Previously published studies showed that these...
-
Performance optimization of continuous-time OTA-C filters.
PublicationW pracy przedstawiono analityczne podejśćie do optymalizacji właściwości filtrów OTA-C czasu ciągłego. Zaprezentowano efektywne metody analizy zniekształceń nieliniowych i szumów dla dowolnego filtru OTA-C wykorzystując ogólny model oparty na opisie macierzowym. Rezultaty teoretyczne odnoszące się do kaskadowego filtru typu Butterwotha były weryfikowane na drodze porównawczej z wynikami otrzymanymi na poziomie ''Transistor-Level''...
-
Influence of reactive oxygen species during deposition of iron oxide films by high power impulse magnetron sputtering.
PublicationIron oxide films were deposited using high power impulse magnetron sputtering (HiPIMS) of an iron cathode in an argon/oxygen gas mixture at different gas pressures (0.5~Pa, 1.5~Pa, and 5.0~Pa). The HiPIMS system was operated at a repetition frequency $f = 100$~Hz with a duty cycle of 1~\%. A main goal is a comparison of film growth during conventional and electron cyclotron wave resonance-assisted HiPIMS. The deposition plasma...
-
Growth and properties of Ti-Cu films with respect to plasma parameters in dual-magnetron sputtering discharges
Publication -
Optically transparent boron-doped nanocrystalline diamond films for spectroelectrochemical measurements on different substrates
PublicationFabrication process of optically transparent boron nanocrystalline diamond (BNCD) electrode on silicon and quartz substrate was shown. The B-NCD films were deposited on the substrates using Microwave Plasma Assisted Chemical Vapor Deposition (MWPACVD) at glass substrate temperature of 475 ºC. A homogenous, continuous and polycrystalline surface morphology with high sp3 content in B-NCD films and film thickness depending from substrate...
-
Properties of Thermally Dewetted Thin Au Films on ITO-Coated Glass for Biosensing Applications
PublicationNoble metal nanostructures are object of great interest due to their unique optical and electronic properties exploited in nanotechnology, medicine, biochemistry, and surface-enhanced spectroscopies. In this work, the Au nanoparticle (NP) structures for application in biosensing obtained by dewetting are investigated in dependence on their preparation conditions. Structures are produced from thin Au films (5–30 nm) sputtered onto...
-
Reactive metabolites of acridinone antitumor agents, C-1311 and C-1305, are trapped within the active site of CYP1A2 and CYP3A4, causing irreversible enzymes inactivation
PublicationZwiązki C-1305 i C-1311, zsyntetyzowane w Katedrze Technologii Leków i Biochemii, wykazują najsilniejsze właściwości przeciwnowotworowe wśród pochodnych, odpowiednio, triazolo- i imidazoakrydonu. Obecnie prowadzone są badania mające na celu określenie biochemicznego mechanizmu działania, jak również potencjalnych szlaków biotransformacji C-1305 i C-1311.W bieżącym etapie podjęto próbę określenia mechanizmu obserwowanej inhibicji...
-
Charge-assisted N(+)–H···(−)S hydrogen bonds in the crystal structure of selected diammonium thiophenolates.
PublicationNew salts of thiophenol with three flexible aliphatic diamines H2N(CH2)nNH2 (n = 2, 4 and 6) have been synthesized and characterized by elemental analyses, IR spectroscopy and X-ray crystallography in order to analyze their supramolecular architecture. Structural analyses indicate that in the crystals, proton transfer has occurred, with the –SH group giving (+)N–H···S(−) hydrogen bonding interaction. The structure of compound 1...
-
Molecular dynamics simulations of the growth of poly (chloro-para-xylylene) films.
PublicationParylene C, poly(chloro-para-xylylene) is the most widely used member of the parylene family due to its excellent chemical and physical properties. In this work we analyzed the formation of the parylene C film using molecular mechanics and molecular dynamics methods. A five unit chain is necessary to create a stable hydrophobic cluster and to adhere to a covered surface. Two scenarios were deemed to take place. The obtained results...
-
Efficient tolerance analysis of continuous-time Gm-C filters
PublicationW pracy przedstawiono efektywną metodą analizy tolerancji dowolnych filtrów Gm-C. Przedstawiono ogólny model filtrów Gm-C oraz jego opis algebraiczny. Używając tego podejścia, wyprowadzono formuły pozwalające na wyznaczenie odchyłek funkcji przenoszenia filtru spowodowanych odchyłkami wartości elementów filtru od wartości nominalnych. Proponowana metoda charakteryzuje się niewielką złożonością obliczeniową, co pozwala na jej wykorzystanie...
-
Physical properties of homogeneous TiO2 films prepared by high power impulse magnetron sputtering as a function of crystallographic phase and nanostructure
PublicationOptical, photo-electrochemical, crystallographic and morphological properties of TiO2 thin films prepared by high power impulse magnetron sputtering at low substrate temperatures (<65 ◦C) without post-deposition thermal annealing are studied. The film composition-anatase, rutile or amorphous TiO2-is adjusted by the pressure (p ∼ 0.75-15 Pa) in the deposition chamber. The different crystallographic phases were determined with grazing...
-
Tailoring properties of indium tin oxide thin films for their work in both electrochemical and optical label-free sensing systems
PublicationThis work is devoted to the identification properties of indium tin oxide (ITO) thin films responsible for their possible application in combined optical and electrochemical label-free sensing systems offering enhanced functionalities. Since any post-processing would make it difficult to identify direct relation between deposition parameters and properties of the ITO films, especially when deposition on temperature-sensitive substrates...
-
Acridinone antitumor agents, C-1305 and C-1299 are metabolized rather by flavin-containing monooxygenases and UDP-glucuronosyltransferases than cytochromes P450
PublicationStwierdzono, że to monooksygenazy flawinowe, a nie enzymy cytochromu P450, są głównymi enzymami frakcji mikrosomalnej, odpowiedzialnymi za detoksyfikacyjny metabolizm dwóch badanych pochodnych triazoloakrydonu. Dodatkowo C-1305 ulega sprzęganiu w czasie drugiej fazy metabolizmu z kwasem glukuronowym do postaci O-glukuronidu
-
The mechanical properties and bactericidal degradation effectiveness of tannic acid-based thin films for wound care
PublicationThe surface area is the most important aspect when considering the interactions between a material and the surrounding environment. Chitosan (CTS) and tannic acid (TA) were previously successfully tested by us to obtain thin films to serve as wound dressings or food packaging materials. However, surface properties as well as the antimicrobial activity of the material were not considered. They are important if the material is likely...
-
Spectral reflectance and transmission modeling of multi-cavity Fabry-Pérot interferometer with ZnO thin films
PublicationIn this paper spectral reflectance and transmission of a low-coherence fiber-optic Fabry-Pérot interferometer with thin ZnO layers is analyzed using a multi-cavity approach. In the investigated setup two standard single-mode optical fibers (SMF-28) with thin ZnO films deposited on their end-faces form an extrinsic Fabry-Pérot interferometer with air cavity. Calculations of the spectral response of the interferometer were performed...
-
Plasmon-enhanced photoluminescence from TiO2 and TeO2 thin films doped by Eu3+ for optoelectronic applications
PublicationIn this work we study the luminescence properties of europium-doped titanium dioxide and tellurium oxide thin films enhanced by gold plasmonic nanostructures. We propose a new type of plasmon structure with an ultrathin dielectric film between plasmonic platform and luminescent material. Plasmonic platforms were manufactured through thermal annealing of the gold thin film. Thermal dewetting of gold film results in spherical gold...
-
Diminshed toxicity of C-1748, 4-methyl-9-hydroxyethylamino-1-nitroacridine, compared with its demethyl analog, C-857, corresponds to its resistance to metabolism in HepG2 cells
PublicationThe narrow "therapeutic window" of anti-tumour therapy may be the result of drug metabolism leading to the activation or detoxification of antitumour agents. The aim of this work is to examine (i) whether the diminished toxicity of a potent antitumour drug, C-1748, 9-(2'-hydroxyethylamino)-4-methyl-1-nitroacridine, compared with its 4-demethyl analogue, C-857, results from the differences between the metabolic pathways for the...
-
Changes on the Surface of the SiO2/C Composite, Leading to the Formation of Conductive Carbon Structures with Complex Nature of DC Conductivity
PublicationSol–gel layers have been the subject of many studies in recent decades. However, very little information exists about layers in which carbon structures are developed in situ. Using the spin-coating method, we obtained thin iron-doped SiO2/C composite films. The results of Raman spectroscopy showed that our samples consisted of graphitic forms and polymers. The latter’s contribution decreases with rising temperature. FTIR and EDS...
-
Cross-linking of polymer films using phenol-formaldehyde resins with different functional groups
PublicationWell-know phenol-formaldehyde resins are used in the production of press-materials, glues, protective coating, mastics. They take a special place among known oligomers because the products based on them are characterized by a low cost and a series of positive properties. Aim of the work: to show the possibility to create polymeric films based on epoxy resins and modified phenol-formaldehyde resins, which contain unsaturated double...
-
Mechanism of Isomerization and Acid-Induced Transformations of 3-Hydroxy-4,4'-dimethoxy-3'-methyl-3-oxo-7,7'-bis(piperidino-carbonyloxy)-2,2'-spirobi-[2H,2'H,3H,3'H-benzo[b]thiophene]. Unusual Equilibrium between the Spiro and 3-Hydroxy-benzothiophene Systems.
PublicationStwierdzono, że 3'-hydroksy-4,4'-dimetoksy-3'-metylo-3-okso-7,7'-bis(piperydynokarbonyloksy)-2,2'-spirobi[2H,2'H,3H,3'H-benzo[b]tiofen] występuje w roztworach postaci mieszaniny dwóch diastereoizomerów pozostających w dynamicznej równowadze. Mechanizm tej równowagi oparty jest na odwracalnym otwarciu pierścienia z 1,5 przeniesieniem protonu i utworzeniu przjściowej formy 3-hydroksybenzotiofenu.
-
Dokumentacja oraz wnioski z badań belek hybrydowych w II etapie dla firmy H+H Polska sp. z o.o.
PublicationOpracowanie stanowi dokumentację oraz wnioski z badań belek nadprożowych o długości 3,0 m każda o przekroju poprzecznym belki hybrydowej
-
Determination of Local Dye Concentration in Hybrid Porous Silica Thin Films
PublicationThe idea of determination of local dye concentration in a nanoporous matrix is proposed based on donor − acceptor energy transfer. The method was tested for a Rhodamine 110 − Rhodamine 101 system in silica and methylated silica nanolayers. Evaluation of acceptor (Rhodamine 101) local concentration was carried out by comparing the results of Monte Carlo simulation of energy transfer from donor (Rhodamine 110) to acceptor (Rhodamine...
-
A review of design approaches for the implementation of low-frequency noise measurement systems
PublicationElectronic noise has its roots in the fundamental physical interactions between matter and charged particles, carrying information about the phenomena that occur at the microscopic level. Therefore, Low-Frequency Noise Measurements (LFNM) are a well-established technique for the characterization of electron devices and materials and, compared to other techniques, they offer the advantage of being non-destructive and of providing...
-
Rubrene Thin Films with Viably Enhanced Charge Transport Fabricated by Cryo-Matrix-Assisted Laser Evaporation
PublicationAmong organic semiconductors, rubrene (RB; C42H28) is of rapidly growing interest for the development of organic and hybrid electronics due to exceptionally long spin diffusion length and carrier mobility up to 20 cm2V−1s−1 in single crystals. However, the fabrication of RB thin films resembling properties of the bulk remains challenging, mainly because of the RB molecule’s twisted conformation. This hinders the formation of orthorhombic...
-
Analysis and Optimization of Noise in Continuous-Time OTA-C Filters
PublicationW pracy przedstawiono ogólną procedurę analizy szumów w filtrach klasy OTA-C czasu ciągłego. Procedura umożliwia analizę filtrów o dowolnej topologii i dowolnego rzędu w ramach rozważanej klasy. W oparciu o opis macierzowy ogólnej struktury filtru OTA-C wyprowadzono ogólne formuły pozwalające na wyznaczanie i optymalizację szumów dowolnego filtru OTA-C. Przedstawione wyniki są użyteczne nie tylko dla klasycznych (dyskretnych lub...
-
Enhanced Activity of P4503A4 and UGT1A10 Induced by Acridinone Derivatives C-1305 and C-1311 in MCF-7 and HCT116 Cancer Cells: Consequences for the Drugs’ Cytotoxicity, Metabolism and Cellular Response
PublicationActivity modulation of drug metabolism enzymes can change the biotransformation of chemotherapeutics and cellular responses induced by them. As a result, drug-drug interactions can be modified. Acridinone derivatives, represented here by C-1305 and C-1311, are potent anticancer drugs. Previous studies in non-cellular systems showed that they are mechanism-based inhibitors of cytochrome P4503A4 and undergo glucuronidation via UDP-glucuronosyltranspherase...
-
Transformation of bimetallic Ag–Cu thin films into plasmonically active composite nanostructures
PublicationFormation of plasmonically active silver, copper and composite silver-copper nanostructures were studied in this paper. Metallic nanostructures were fabricated by thermal disintegration, so called dewetting, of the thin films in an argon atmosphere. The formation process of the nanostructures was in-situ observed by a novel method, based on resistance measurements. The influence of the material and thickness of the initial thin...
-
General Description of State-Space Continuous-Time Gm-C Filters
PublicationW pracy przedstawiono ogólne podejście do analogowych filtrów Gm-C czasuciągłego, oparte o opis macierzowy. Przedstawiono związki pomiędzy sieciąpasywną filtru a funkcją przenoszenia. Podano nową definicję filtrów zmien-nych stanu Gm-C oraz opisano dwie interesujące podklasy filtrów Gm-C jakrównież podano kanoniczne transformacje przekształcające struktury z pojem-nościami nieuziemionymi w struktury zawierające wyłącznie...
-
Modeling and experimental investigation of the small UPQC systems
PublicationIn this paper the basis of analytical modelling of the UPQC arrangements (Unified Power Quality Conditioner) in d-q rotating coordinates, as well as select results of investigations conducted on the simplified small power laboratory model were talked over. In short form power balance as well as fundamental dependences and analytic model with regard of decoupling circuits were investigated. Applied method for DC link capacity selection...
-
Pregnane X receptor dependent up-regulation of CYP2C9 and CYP3A4 in tumor cells by antitumor acridine agents, C-1748 and C-1305, selectively diminished under hypoxia
PublicationInduction of proteins involved in drug metabolism and in drug delivery has a significant impact on drug-drug interactions and on the final therapeutic effects. Two antitumor acridine derivatives selected for present studies, C-1748 (9-(2’-hydroxyethylamino)-4-methyl-1-nitroacridine) and C-1305 (5-dimethylaminopropylamino-8-hydroxy-triazoloacridinone), expressed high and low susceptibility to metabolic transformations with liver...
-
Noise Analysis and Optimization of Continuous-Time OTA-C Filters
PublicationW pracy przedstawiono efektywną procedurę wyznaczania szumów w filtrach OTA C czasu ciagłego. Procedura wyprowadzona jest w oparciu o ogólny model filtru OTA C oraz jego opis macierzowy. Podano jawne formuły pozwalające okreslić odniesione do wejścia widmo szumów dowolnego filtru rozważanej klasy. Otrzymane wyniki teoretyczne zostały zweryfikowane poprzez porównanie z wynikami otrzymywanymi za pomocą symulatora SPICE dla wybranych...
-
Spatial characterization of H 2: CH 4 dissociation level in microwave ECR plasma source by fibre-optic OES
PublicationSpatially resolved optical emission spectroscopy (SR-OES) was used to investigate microwave activated H2/Ar/CH4 plasma under conditions of the electron cyclotron resonance (ECR). The chemistry and composition of the gas phase were studied using self-designed fibre-optic system with echelle type spectrometer during CVD deposition of polycrystalline diamond. One-dimensional intensity profiles of the main species were collected along...
-
The Influence of PEDOT to PSS Ratio on the Optical Properties of PEDOT:PSS Thin Solid Films - Insight from Spectroscopic Ellipsometry
Publication -
Intensification of catechin extraction from the bark of Syzygium cumini using ultrasonication: Optimization, characterization, degradation analysis and kinetic studies
PublicationCatechin is a prominent polyphenolic component that possesses various medicinal properties. Present work communicates the intensification and optimization of catechin extraction from the bark of Syzygium cumini tree using stirred reactor, soxhlet, ultrasonic bath, and ultrasonic horn technique. The optimization of several parameters such as type of solvent, solid to solvent ratio (1:100 w/v), speed of agitation (300 RPM), extraction...
-
Determination of Antioxidant Activity of Vitamin C by Voltammetric Methods
PublicationVoltammetric methods—cyclic (CV) and differential pulse voltammetry (DPV) are considered the most appropriate way to evaluate antioxidant activity of redox active compounds. They provide information about both mechanism and kinetics of electrochemical oxidation of antioxidants as well as their physical and chemical properties such as the redox potential or the number of electrons transferred. These methods are helpful for understanding...
-
Formation of carboxymethyl cellulose–casein complexes by electrosynthesis
Publication -
Electrosynthesis of carboxymethyl cellulose – ovoalbumin complexes
Publication -
Thin LSFO films for bolometers
PublicationPrzedstawiono metodę produkcji oraz temperaturowe zależności rezystancji cienkich warstw niestechiometrycznych tlenków (La,Sr)FeO3 (LSFO) przeznaczonych do zastosowań na detektory podczerwieni
-
Nonlinear distortion analysis and optimisation of general OTA-C filters.
PublicationW pracy przedstawiono opis analityczny ogólnej struktury filtrów OTA-C zawierających nieliniowe elementy aktywne. Wprowadzono nieliniowy układ równań różniczkowych zwyczajnych opisujący dynamikę tej klasy układów aktywnych. Opis ten pozwala, przy użyciu standardowych metod numerycznych, na przeprowadzenie efektywnej analizy czasowej filtrów OTA-C. Proponowane podejście może być stosowane do badania dowolnych efektów nieliniowych...
-
Rigorous numerics for critical orbits in the quadratic family
PublicationWe develop algorithms and techniques to compute rigorous bounds for finite pieces of orbits of the critical points, for intervals of parameter values, in the quadratic family of one-dimensional maps fa(x)=a−x2. We illustrate the effectiveness of our approach by constructing a dynamically defined partition P of the parameter interval Ω=[1.4,2] into almost 4 million subintervals, for each of which we compute to high precision the...
-
Breakdown of Adiabatic Superconductivity in Ca-Doped h-BN Monolayer
Publication -
Role of the sulfur to α-carbon thioether bridges in thurincin H
Publication -
Numerically robust synthesis of discrete-time H-inf estimators based on dual J-lossless factorisations.
PublicationW pracy przedstawiono numerycznie stabilną metodę syntezy liniowych estymatorów stanu optymalnych ze względu na wymagania formułowane w oparciu o normę H-inf. Wykorzystano dualną J-bezstratną faktoryzację macierzy rozproszenia estymowanego procesu czasu dyskretnego. Badano numeryczne uwarunkowanie odpowiednich równań Riccatiego. W szczególności pokazano, że dla dostatecznie małych wartości okresu próbkowania zadanie syntezy dotyczące...
-
A Single-Carrier-Based Pulse-Width Modulation Template for Cascaded H-Bridge Multilevel Inverters
PublicationMultiplicity of the triangular carrier signals is a criterion for the extension of sinusoidal pulsewidth modulation, SPWM, to a number of output voltage levels per phase-leg in cascaded H-bridge (CHB) multilevel inverter (MLI). Considering medium and high voltage applications where appreciable number of output voltage levels from CHB MLI is needed, commensurate high number of carrier signals in either classical level- or phase-shifted...
-
Combined chemoresistive and in situ FTIR spectroscopy study of nanoporous NiO films for light-activated nitrogen dioxide and acetone gas sensing
PublicationThe chemoresistive sensor response of nanoporous NiO films prepared by advanced gas deposition was investigated by combined resistivity and in situ FTIR spectroscopy, with and without simultaneous light illumination, to detect NO2 and acetone gases. The sensitivity towards NO2 increased dramatically under UV irradiation employing 275 nm light. Improved sensitivity was observed at an elevated temperature of 150 °C. In situ FTIR...
-
Role of methylation in electron scattering on X(CH3)4 (X= C, Si, Ge) molecules (2)
PublicationTo investigate how replacement of H atom with methyl group (CH3) – in tetrahedral compounds of carbon, silicon and germanium – affects electron scattering process, total cross sections (TCS) for electron scattering from C(CH3)4, Si(CH3)4 and Ge(CH3)4 molecules have been compared with data for CH4, SiH4 and GeH4 molecules. All examined data have been obtained with the same experimental setup. The shape of all discussed TCS energy...
-
C-1311 (Symadex), a potential anti-cancer drug, intercalates into DNA between A and G moieties. NMR-derived and MD-refined stereostructure of the d(GAGGCCTC) 2 :C-1311 complex
PublicationImidazoacridinone C-1311 (Symadex®) is an antitumor agent which has been recommended for Phase II clinical trials a few years ago. Previously, it was shown experimentally that during the initial stage of its action C-1311 forms stable intercalation complexes with DNA duplexes. Herein, a NMR-derived stereostructure of d(GAGGCCTC)2:C-1311 complex was reported. The ligand was found locating itself between A and G moieties, forming...
-
Ellipsometric investigation of nitrogen doped diamond thin films grown in microwave CH4/H2/N2 plasma enhanced chemical vapor deposition
PublicationThe influence of N2 concentration (1%–8%) in CH4/H2/N2 plasma on structure and optical properties of nitrogen doped diamond (NDD) films was investigated. Thickness, roughness, and optical properties of the NDD films in the VIS–NIR range were investigated on the silicon substrates using spectroscopic ellipsometry. The samples exhibited relatively high refractive index (2.6 6 0.25 at 550 nm) and extinction coefficient (0.05 6 0.02...
-
Potential degradation of norfloxacin using UV-C/Fe2+/peroxides-based oxidative pathways
PublicationThe removal of norfloxacin (NOR), a widely used pharmaceutical and emerging water pollutant, was studied using UV-C and Fe2+ catalyzed peroxides-based oxidative processes (e.g., UV-C/Fe2+/H2O2, UV-C/Fe2+/S2O82− and UV-C/Fe2+/HSO5−) and compared with UV-C and UV-C/Fe2+. The UV-C and UV-C/Fe2+ degraded NOR to 38 and 55 %. However, use of peroxides, i.e., H2O2, S2O82−, HSO5− with UV-C and UV-C/Fe2+ promoted NOR %degradation to 75,...
-
Preparation, characterization and antimicrobial activity of polyvinyl alcohol/gum arabic/chitosan composite films incorporated with black pepper essential oil and ginger essential oil
PublicationIn this study, biocomposite films based on polyvinyl alcohol (PVA), gum arabic (GA) and chitosan (CS) incorporated with BPEO and GEO were fabricated by solvent casting method. FTIR, XRD, SEM and DSC were performed with mechanical and antimicrobial properties of PVA/GA/CS films with and without BPEO and GEO. The BPEO and GEO incorporated PVA/GA/CS films were significantly inhibited the growth of Bacillus cereus, Staphylococcus aureus,...
-
Antitumour imidazoacridone C-1311 induces cell death by mitotic catastrophe in human colon carcinoma cells
PublicationW przedstawionych badaniach określano mechanizm śmierci komórkowej indukowanej przez imidazoakrydon C-1311 (Symadex) w komórkach HT-29 ludzkiego raka jelita grubego, które wykazywały szczególną wrażliwość na ten związek w eksperymentalnych modelach in vitro i in vivo. Przy stężeniu odpowiadającemu dawce IC99, związek powodował zahamowanie progresji cyklu komórkowej w fazie S po czym następował blok w fazie G2. Po czasach 48-96...
-
Low-Coherence Interferometer with Nanocrystalline Diamond Films with Potential Application to Measure Small Biological Samples
PublicationThe study investigates a case of a low-coherence fiber-optic Fabry–Prerot interferometer with a nanocrystalline diamond (NCD) mirror. The method of achieving double density of interference fringes is proposed by the application of birefringent material in the cavity of the interferometer. It can be used to reduce sample volume in comparison to conventional interferometers. The use of a biocompatible diamond mirror makes it specifically...
-
Prediction of the structures of proteins with the UNRES force field, including dynamic formation and breaking of disulfide bonds
Publication -
Electron scattering by trimethylene oxide, c-(CH2)3O, molecules
PublicationZmierzono całkowity przekrój czynny na rozproszenie elektronów na drobinach c-(CH2)3O w zakresie energii 1 - 400 eV. Wyniki porównano z elastycznymi i jonizacyjnymi przekrojami czynnymi obliczonymi dla tej drobiny. Przedyskutowano energetyczną zależność całkowitego przekroju czynnego na rozproszenie dla rodziny eterów cyklicznych (CH2)nO, n=2-4.
-
Canonic structures of old order elliptic Gm-C filters.
PublicationW pracy zaproponowano nowe struktury kanoniczne eliptycznych filtrów Gm-Crzędów nieparzystych. Opracowane układy filtrów wymagają małej liczby elementów zarówno aktywnych jak i pasywnych niezbędnych do realizacji żądanych charakterystyk częstotliwościowych.W pracy są również zaprezentowane rezultaty porównań właściwości przedstawionych struktur z przykładami realizacji układowych innych filtrów Gm-C.
-
Microstructure and Electrical Properties of Fe,Cu Substituted (Co,Mn)3O4 Thin Films
PublicationIn this work, thin films (~1000 nm) of a pure MnCo2O4 spinel together with its partially substituted derivatives (MnCo1.6Cu0.2Fe0.2O4, MnCo1.6Cu0.4O4, MnCo1.6Fe0.4O4) were prepared by spray pyrolysis and were evaluated for electrical conductivity. Doping by Cu increases the electrical conductivity, whereas doping by Fe decreases the conductivity. For Cu containing samples, rapid grain growth occurs and these samples develop cracks...
-
Properties of ordered titanium templates covered with Au thin films for SERS applications
PublicationtCurrently, roughened metal nanostructures are widely studied as highly sensitive Raman scattering sub-strates that show application potential in biochemistry, food safety or medical diagnostic. In this workthe structural properties and the enhancement effect due to surface enhanced Raman scattering (SERS) ofhighly ordered nano-patterned titanium templates covered with thin (5–20 nm) gold films are reported.The templates are formed...
-
Thermal dewetting as a method of surface modification of the gold thin films for surface plasmon resonance based sensor applications
PublicationHere, we report a quick and simple approach with low, optimized production costs to obtain surface plasmon resonance (SPR) based sensors fabricated through a time- and resource-effective method based on thermal dewetting of thin Au films. From the applicative point of view, the method of detection presented here should be easier to implement, since light transmission measurements seem to be much less challenging than light refractive...
-
Anforderungen an Umkehrdacher mit Trennlage.
PublicationArtykuł zajmuje się problemem strat ciepła w dachach odwróconych. Uwzględniono dodatkowe straty ciepła spowodowane opadem deszczu. Omówiono zastosowanie normy EN ISO 6946 w różnych rejonach Europy.
-
A Wideband Rotary-Joint-Free H-Plane Horn Antenna With 360° Steerable Radiation Pattern Using Gap Waveguide Technology
PublicationConsidering the limitations of electronically steerable antennas such as limited steering span, gain degradation for large steering angles, complexity, and cost, this article is focused on the design of a simple mechanically steerable H-plane horn antenna. It is shown that since there is no need for an electrical connection between the top and bottom sections of a gap waveguide (GWG), if a sectoral horn is properly designed and realized...
-
Induction of G2/M phase arrest and apoptosis of human pancreatic cancer BxPC-3 cells by potenet antitumor 1-nitroacridine derivative C-1748
PublicationPancreatic ductal adenocarcinoma (PDA) is among the most lethal human cancers, in part because it is insensitive to many chemotherapeutic drugs. Gemcitabine still remains the best chemotherapeutic agent available for the treatment of advanced pancreatic cancer. However, gemcitabine treatment results in only a marginal survival advantage. Thus, there is a strong need for the continuous development of novel therapeutic agents...
-
Elektrownia Ostrołęka C w budowie a „momentum-FSI”
PublicationMimo przeszkód, trwa budowa elektrowni Ostrołęka C. O tym zapewniają nas główni decydenci – Jarosław Małkowski, Prezes Elektrowni Ostrołęka, czy Sławomir Żygowski, Prezes GE Power, firmy odpowiedzialnej projekt, wykonanie i budowę. Możemy o tym dowiedzieć się w mediach społecznościowych. Ale te same media informują również, że 31 lipca 2019 r. Sąd okręgowy w Poznaniu stwierdził nieważność uchwały Walnego Zebrania Akcjonariuszy...
-
Path integrals formulations leading to propagator evaluation for coupled linear physics in large geometric models
PublicationReformulating linear physics using second kind Fredholm equations is very standard practice. One of the straightforward consequences is that the resulting integrals can be expanded (when the Neumann expansion converges) and probabilized, leading to path statistics and Monte Carlo estimations. An essential feature of these algorithms is that they also allow to estimate propagators for all types of sources, including initial conditions....
-
The ability of new sugar-modified derivatives of antitumour anthracycline, daunorubicin, to stimulate NAD(P)H Oxidation in Different Cellular Oxidoreductase Systems: NADH Dehydrogenase, NADPH Cytochrome P450 Reductase, and Xanthine Oxidase.
PublicationUboczne działanie cytostatyków z grupy antracyklin prowadzi do uszkodzenia serca (kardiotoksyczność) w wyniku pośredniczenia przez te związki przeniesienia jednoelektronowego ze zredukowanych nukleotydów do tlenu i powstania reaktywnych anionorodników tlenowych. Proces ten jest katalizowany głównie przez trzy enzymy: dehydrogenazę NADH, reduktazę NADPH/cytochrom P450 oraz oksydazę ksantynową. W publikacji przedstawione są wyniki...
-
The Imidazoacridinone Antitumor Drug, C-1311, Is Metabolized by Flavin Monooxygenases but Not by Cytochrome P450s.
PublicationPrezentowane w publikacji wyniki badań mają na celu wyjaśnienie roli enzymów wątrobowych w metabolizmie przeciwnowotworowych pochodnych C-1311 oraz C-1330. Oba związki inkubowane były z frakcją mikrosomalną oraz enzymami rekombinantowymi należącymi do grypy cytochromu P450, FMO oraz UGT. Badania wykazały, że oba związki są metabolizowane przez enzymy frakcji mikrosomalnej, ale nie przez enzymy cytochromu P450. Aktywność enzymatyczna...
-
Correlation between the Reactivity and Spectroscopic Properties of N-Substituted Secondary Thioamides. New Intramolecular N• •H+• •N Binding Approach and Proton Complexes Based on Thioamide Ligation
PublicationFrom a comparison of chem. shifts and wavenumbers of several secondary thioamides and amides having monocationic substituents attached to thiocarbamoyl or carbamoyl groups by a polymethylene chain, new intramol. unconventional N···H+···N H bonding effects were discovered. It is argued that the CH2-N rotation is hindered and two +H···NHMe nonequiv. protons occur in a proton spectrum of hydrochloride RCH2C(S)NH(CH2)3NHMe-HCl...
-
Canonic structures of odd-order elliptic Gm-C filters.
PublicationW pracy zaproponowano nowe rozwiązania układowe struktur kanonicznych eliptycznych filtrów Gm-C czasu ciągłego, rzedu nieparzystego. Opracowane struktury charakteryzują się małą liczbą elementów pasywnych oraz aktywnych i są przewidziane do zastosowań w filtrach niskomocowych o małej wrażliwości. W przeprowadzonych badaniach porównywano wybrane struktury 3-go rzędu pod względem właściwości i wymagań układów scalonych, w których...
-
Ordered titanium templates functionalized by gold films for biosensing applications – Towards non-enzymatic glucose detection
PublicationRecently, metal nanostructures evoke much interest due to application potential in highly sensitive detectors in biochemistry and medical diagnostics. In this work we report on preparation and characteristics of thin (1–100 nm) Au films deposited onto highly ordered structured titanium templates for SERS (Surface Enhanced Raman Spectroscopy) and electrochemical sensing. The Ti templates are formed by selective removal of TiO2 nanotubes...
-
Anodic titania nanotubes decorated with gold nanoparticles produced by laser-induced dewetting of thin metallic films
PublicationHerein, we combine titania layers with gold species in a laser-supported process and report a substantial change of properties of the resulting heterostructures depending on the major processing parameters. Electrodes were fabricated via an anodisation process complemented with calcination to ensure a crystalline phase, and followed by magnetron sputtering of metallic films. The obtained TiO2 nanotubes with deposited thin (5, 10...
-
Equivalence of equicontinuity concepts for Markov operators derived from a Schur-like property for spaces of measures
PublicationVarious equicontinuity properties for families of Markov operators have been – and still are – used in the study of existence and uniqueness of invariant probability for these operators, and of asymptotic stability. We prove a general result on equivalence of equicontinuity concepts. It allows comparing results in the literature and switching from one view on equicontinuity to another, which is technically convenient in proofs....
-
In plane and out of plane temperature dependencies of the resistivity insingle crystals and films of Nd2CuO4.
PublicationW pracy przedstawiono temperaturową zależność oporu elektrycznego kryształów i cienkich warstw związku Nd2CuO4. Dyskutowany jest wpływ temperatury i atmosfery dodatkowej obróbki termicznej na własności transportowe.
-
In-plane and out-of-plane temperature dependencies of the resistivity in single crystals and films of Nd2CuO4
Publication -
Technique to improve CMRR at high frequencies in CMOS OTA-C filters
PublicationIn this paper a technique to improve the common-mode rejection ratio (CMRR) at high frequencies in the OTA-C filters is proposed. The technique is applicable to most OTA-C filters using CMOS operational transconductance amplifiers (OTA) based on differential pairs. The presented analysis shows that a significant broadening of CMRR bandwidth can be achieved by using a differential pair with the bodies of transistors connected to...
-
Pulsed Laser Deposition of Bismuth Vanadate Thin Films—The Effect of Oxygen Pressure on the Morphology, Composition, and Photoelectrochemical Performance
PublicationThin layers of bismuth vanadate were deposited using the pulsed laser deposition technique on commercially available FTO (fluorine-doped tin oxide) substrates. Films were sputtered from a sintered, monoclinic BiVO4 pellet, acting as the target, under various oxygen pressures (from 0.1 to 2 mbar), while the laser beam was perpendicular to the target surface and parallel to the FTO substrate. The oxygen pressure strongly affects...
-
Enhancement of fiber-optic low-coherence Fabry-Pérot interferometer with ZnO ALD films
PublicationIn this paper investigation of the enhanced fiber-optic low coherence Fabry-Pérot interferometer with zinc oxide (ZnO) film deposited by atomic layer deposition (ALD) was presented. Model of the interferometer, which was constructed of single-mode optical fiber with applied ZnO ALD films, was built. The interferometer was also examined by means of experiment. Measurements were performed for both reflective and transmission modes,...
-
The effect of UV-C irradiation on lipids and selected biologically active compounds in human milk
PublicationThe effect of UV-C irradiation of human milk on lipid oxidation, content of antioxidants (vitamin C and catalase, CAT) and bactericidal compounds (lysozyme), as well as the total antioxidant capacity (TAC), of the breast milk was investigated. In parallel, the extent of inactivation of some bacteria was also determined. UV-C at doses from 85 to 740 J L−1 caused total inactivation of Escherichia coli and Staphylococcus aureus, but...
-
User experience evaluation study on the quality of 1K, 2K, and 4K H.265/HEVC video content
PublicationNowadays, most content creators focus on distributing rich media at the highest possible resolution. Currently, the majority of sold consoles, media players, computer hardware, as well as displays and TVs are advertised as 4K-compatible. The same trend is observed in the case of popular online streaming services and terrestrial TV broadcasts. Generally speaking, it is assumed that higher bitrates provide higher subjective judgements....
-
Electrochemical and in silico approaches for liver metabolic oxidation of antitumor-active triazoloacridinone C -1305
Publication5-Dimethylaminopropylamino-8-hydroxytriazoloacridinone (C-1305) is a promising antitumor compound developed in our laboratory. A better understanding of its metabolic transformations is still needed to explain the multidirectional mechanism of pharmacological action of triazoloacridinone derivatives at all. Thus, the aim of the current work was to predict oxidative pathways of C-1305 that would reflect its phase I metabolism. The...
-
Effect of ground plane size on radiation pattern in IFF/SSR microstrip antenna on thick substrate fed by H type slot
PublicationW pracy pokazano numeryczne i eksperymentalne wyniki badania wpływu rozmiarówmasy na charakterystyki promieniowania anteny dla zastosowań IFF/SSR, zrealizowanej na grubym podłożu i zasilanej przez szczelinę typu H. Pokazane wyniki dla anteny oryginalnej porównano z wynikami uzyskanymi po zmniejszeniu wymiarów masy (w każdym z kierunków). Pokazano jak dalece można zminimalizować wymiary anteny, przy założonym poziomie listków bocznych.
-
Demonstrator technologii C-IED
PublicationArtykuł przedstawia budowę i działanie opracowanego na Politechnice Gdańskiej demonstratora technologicznego systemu AEGIS, przeznaczonego do przeciwdziałania atakom z wykorzystaniem prowizorycznych urządzeń wybuchowych detonowanych drogą radiową (RCIED — Radio Controlled Improvised Explosive Devices). Przedstawiono zaimplementowaną oryginalną metodę generowania sygnału zagłuszającego o dowolnie ukształtowanym widmie częstotliwościowym,...
-
A Hierarchical Multiscale Approach to Protein Structure Prediction: Production of Low‐Resolution Packing Arrangements of Helices and Refinement of the Best Models with a United‐Residue Force Field
Publication -
Numerical study on pounding between two adjacent buildings under earthquake excitation
PublicationSeismic excitation, which results in large horizontal relative displacements, may cause collisions between two adjacent structures due to insufficient separation distance between them. Such collisions, known as earthquake-induced structural pounding, may induce severe damages. In this paper, the case of pounding between two adjacent buildings is studied by the application of single degree-of-freedom structural models. Impact is...
-
Design of dimensionally stable composites using efficient global optimization method
PublicationDimensionally stable material design is an important issue for space structures such as space laser communication systems, telescopes, and satellites. Suitably designed composite materials for this purpose can meet the functional and structural requirements. In this paper, it is aimed to design the dimensionally stable laminated composites by using efficient global optimization method. For this purpose, the composite plate optimization...
-
Verification of Formulas for Periods of Adjacent Buildings Used to Assess Minimum Separation Gap Preventing Structural Pounding during Earthquakes
PublicationInsufficient separation distance between adjacent buildings may lead to serious damages during earthquakes due to structural pounding. The best way to prevent collisions is to provide sufficiently large separation distance between the structures. In this paper, the periods of two closely-spaced linear and nonlinear buildings have been investigated so as to accurately assess the minimum in-between separation gap. A new equation...
-
A comparative study on the decolorization of Tartrazine, Ponceau 4R, and Coomassie Brilliant Blue using persulfate and hydrogen peroxide based Advanced Oxidation Processes combined with Hydrodynamic Cavitation
PublicationDecolorization of Ponceau 4R, Tartrazine, and Coomassie Brilliant Blue (CBB) was studied using hybrid processes of hydrodynamic cavitation (HC) with potassium persulfate (KPS) and hydrogen peroxide (H2O2). The different properties of these dyes such as hydrophobicity, molecular structures, and molecular weights provided this opportunity to investigate the effects of these factors by comparing the decolorization values of the dyes....
-
Thermally activated persulfate-based Advanced Oxidation Processes — recent progress and challenges in mineralization of persistent organic chemicals: a review
PublicationThermally activated persulfate (TAP) finds application in Advanced Oxidation Processes for the removal of pollutants from contaminated water and soil. This paper reviewed the various cases of TAP in the environmental remediation. The pollutants such as individual pharmaceuticals, biocides, cyclic organic compounds, and dyes are considered in this review. It is interesting to note that most of the organic compounds undergo complete...
-
The antitumor compound triazoloacridinone C-1305 inhibits FLT3 kinase activity and potentiates apoptosis in mutant FLT3-ITD leukemia cells.
PublicationAim: FMS-like receptor tyrosine kinase (FLT3) is expressed in some normal hematopoietic cell types and plays an important role in the pathogenesis of acute myeloid leukemia (AML). In this study, we examined the effects of triazoloacridinone C-1305, an antitumor compound, on AML cells with different FLT3 status in vitro. Methods: A panel of human leukemic cell lines with different FLT3 status was used, including FLT3 internal tandem...
-
Structure generation and performance comparison of elliptic Gm-C filters.
PublicationW oparciu o zestaw macierzy opisujący ogólną topologię filtrów typu Gm-C opracowano procedurę efektywnej generacji struktur filtrów dolnoprzepustowych. Dla filtrów tego typu podano wyrażenia pozwalające analizować właściwości wrażliwościowe oraz określono zestaw odpowiednich kryteriów porównawczych. Szczegółowe badania porównawcze przeprowadzono dla wybranych filtrów 3-go rzędu w tym realizowanych w strukturach LF(leapfrog) i...
-
Fluctuation enhanced gas sensing using UV irradiated Au-nanoparticle-decorated WO3-nanowire films
PublicationWO3 nanowires (WO3-NWs) decorated with gold nanoparticles (AuNPs) were utilized in resistive gas sensor devices to detect ethanol by use of fluctuation enhanced sensing (FES). The experimental system records both DC resistance and fluctuations of the sensing film. Our data verify that the sensitivity and selectivity of the gas sensor are improved by applying FES when the sensor is stimulated with a combination of UV light and heating....
-
Analogowy filtr Gm-C odbiornika GSM z automatycznym dostrajaniem częstotliwości
PublicationW referacie przedstawiono scalony analogowy filtr CMOS Gm-C z układem automatycznego dostrajania charakterystyk częstotliwościowych, spełniający wymagania filtru kanałowego odbiornika telefonii komórkowej GSM. Jest to w pełni różnicowy dolnoprzepustowy filtr eliptyczny 5-go rzędu, charakteryzujący się niskim poborem mocy (2,4 mW) i małą powierzchnią struktury krzemowej (0,31 mm2). Częstotliwość graniczna filtru jest dostrajana...
-
I-lossless factorisations for robust H-inf-control in delta-domain
Publication...
-
Microwave-assisted hydrothermal synthesis and electrochemical studies of α- and h-MoO3
Publication -
Common functionally important motions of the nucleotide‐binding domain of H sp70
Publication -
Characterization of Optical and Electrical Properties of Transparent Conductive Boron-Doped Diamond thin Films Grown on Fused Silica
PublicationA conductive boron-doped diamond (BDD) grown on a fused silica/quartz has been investigated. Diamond thin films were deposited by the microwave plasma enhanced chemical vapor deposition (MW PECVD). The main parameters of the BDD synthesis, i.e. the methane admixture and the substrate temperature were investigated in detail. Preliminary studies of optical properties were performed to qualify an optimal CVD synthesis and film parameters...
-
Soiling Effect Mitigation Obtained by Applying Transparent Thin-Films on Solar Panels: Comparison of Different Types of Coatings
PublicationDust accumulation on the front cover of solar panels is closely linked to location and orientation of photovoltaic (PV) installation. Its build-up depends on the module tilt angle, frequency of precipitation, humidity, wind strength and velocity, as well as grain size. Additionally, soil composition is determined by solar farm surroundings such as local factories, agricultural crops, and traffic. Over time, molecules of atmospheric...
-
Anticancer Imidazoacridinone C-1311 is Effective in Androgen-Dependent and Androgen-Independent Prostate Cancer Cells
PublicationAndrogen receptor (AR) plays a crutial role in prostate cancer (PCa) development and metastasis. Here, we reported potent anti-PCa activity of a small molecule imidazoacridinone C-1311. In AR-positive PCa cells, C-1311 was found to inhibit the transcriptional activity of AR uncovering a novel mechanism that may be relevant for its anticancer effect. Mechanistically, C-1311 decreased AR binding to prostate-specific antigen (PSA)...
-
Thermal Instability of Gold Thin Films
PublicationThe disintegration of a continuous metallic thin film leads to the formation of isolated islands, which can be used for the preparation of plasmonic structures. The transformation mechanism is driven by a thermally accelerated diffusion that leads to the minimalization of surface free energy in the system. In this paper, we report the results of our study on the disintegration of gold thin film and the formation of nanoislands...
-
Fragrant films on the basis of potato starch
Publication -
Fragrant starch-based films with limonene
Publication