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Mechanism of Osmolyte Stabilization–Destabilization of Proteins: Experimental Evidence
PublicationIn this work, we investigated the influence of stabilizing (N,N,N-trimethylglycine) and destabilizing (urea) osmolytes on the hydration spheres of biomacromolecules in folded forms (trpzip-1 peptide and hen egg white lysozyme─hewl) and unfolded protein models (glycine─GLY and N-methylglycine─NMG) by means of infrared spectroscopy. GLY and NMG were clearly limited as minimal models for unfolded proteins and should be treated with...
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Assessing groundwater vulnerability to pollution in the Puck region (denudation moraine upland) using vertical seepage method
PublicationDegradation of groundwater quality can cause a serious water supply and environmental problems. The identify of potential groundwater pollution can be determined by assessment of groundwater vulnerability method. The assessment of groundwater vulnerability to pollution was based on estimation of migration time of potential conservative contamination through the vadose zone. Area of investigation is a type of denudation moraine...
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Threshold Attendance under Soft-Crash Model: TAG Protocol and Markovian Analysis
PublicationA realistic and systematic network evaluation should subsume an availability model and a failure model. We combine a "hard availability" model we call threshold attendance, whereby a certain minimum number of network elements must be present at any time, with a soft-crash failure model, whereby after experiencing a failure, a network element is still able to function correctly for a while in an emergency mode at a risk of a major...
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Laboratory test rig for examining aggregate mining from seabed using the AIRLIFT method
PublicationThe use of the Airlift method for transporting the mined aggregate from the seabed to the deck of the mining ship is an alternative for presently used solutions, such as suction pumps or scoop transport for instance. Building the laboratory test rig was preceded by tests in natural conditions. The rig was designed in such a way as to model these conditions as close as possible, and to have potential for further development
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Assessing the time effectiveness of trust management in fully synchronised wireless sensor networks
PublicationThe paper presents the results of the time effectiveness assessment of the distributed WSN Cooperative Trust Management Method - WCT2M in a fully synchronized Wireless Sensor Network (WSN). First we introduce some basic types of synchronization patterns in WSN based on the idea of sleep scheduling. Then we explain how WCT2M works in the network applying the fully synchronized sleep scheduling pattern. Such networks were subjected...
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Instalacje fotowoltaiczne w budownictwie wielorodzinnym
PublicationArtykuł opisuje wpływ instalacji fotowoltaicznych na bezpieczeństwo eksploatacji budynków wielorodzinnych. W oparciu o projekty rzeczywistych obiektów przeprowadzono analizę zwiększenia ryzyka strat odgromowych, zmiany obciążenia konstrukcji dachu i wzrostu zagrożenia pożarowego na skutek montażu systemu fotowoltaicznego. Przeprowadzone obliczenia wskazują na konieczność kompleksowego podejścia do projektowania instalacji fotowoltaicznych....
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Design of new cholinesterase inhibitors based on phosphorus analogs of tacrine as potential anti-Alzheimer’s disease agents
PublicationBased on the analysis of the determined free binding energy (using the AutoDock Vina 1.1.2 docking program), the most potent cholinesterase inhibitors were selected. Moreover, studies of 3D visualization of the results of molecular modeling led to the identification of potential sites for the interaction of new potential inhibitors with amino acid residues building active sites of investigated cholinesterases.
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Self Organizing Maps for Visualization of Categories
PublicationVisualization of Wikipedia categories using Self Organizing Mapsshows an overview of categories and their relations, helping to narrow down search domains. Selecting particular neurons this approach enables retrieval of conceptually similar categories. Evaluation of neural activations indicates that they form coherent patterns that may be useful for building user interfaces for navigation over category structures.
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Membranowe przekrycia wiszące -zagadnienia konstrukcyjno-materiałowe. Membrane hanging roof - constructional-material problems.
PublicationArtykuł przedstawia przykłady zastosowania membranowych przekryć wiszących w budownictwie ogólnym. Dodatkowo zwraca uwagę na wybrane zagadnienia konstrukcyjno-materiałowe tego typu obiektów.This paper presents the application examples of membrane hanging roof in building engineering. Additionally, attention to the chosen constructional-material problems of this type of structures has been focused.
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Energy Efficiency Analysis of Railway Turnout Heating With a Simplified Snow Model Using Classical and Contactless Heating Method
PublicationElectrical heating of railway turnouts is a considerable technical and economic challenge, hence the need to conduct research for optimisation of a railway turnouts heating system. This paper presents results of a numerical analysis and experimental research on heating systems mounted on rail turnouts in line with the classical method and including a heater thermally insulated from the base of a rail. The numerical calculations...
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A Method of MOS Evaluation for Video Based Services
PublicationThis paper deals with a method for QoE evaluation for the services transmitting large amount of data perceived by the end user in relatively short time periods, e.g. streaming video in mobile operator...
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The selected roof covering technologies in the aspect of their life cycle costs
PublicationIn the article is presented an analysis of the life cycle costs calculation for selected roof coverings. The scope of research includes costs of construction, maintenance and demolition of the roof covering structure for two alternative technologies – the traditional and new generation. On the presented example of an industrial building with a roof area of 1000 m², the above costs are taken to consideration for the roof covering...
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Miniaturized Passive Emission Chambers for In Situ Measurement of Emissions of Volatile Organic Compounds
PublicationThe results of many different studies have demonstrated unequivocally that the quality of indoor air is often much worse than that of atmospheric air. The presence of dangerous chemical compounds in indoor air can have an adverse impact on human health and cause numerous diseases of the respiratory and circulatory systems. Such harmful chemicals get into indoor air as a result of their emission from building and indoor materials....
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An incorporation of contemporary daylight assessment methods into architecture and urban planning of residential areas in Poland
PublicationThis paper presents the preliminary results of the ongoing research focusing on daylight design methods for the urban planning of residential areas in Poland. The purpose of this research is to find out if modern daylight performance metrics and design methods can be beneficial to the process of urban residential planning. The paper presents a review of daylight guidelines derived from historic, Polish building regulations. A summary...
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The Impact of Generative AI and ChatGPT on Creating Digital Advertising Campaigns
PublicationThe use of AI-based solutions is currently discussed in relation to various industries. The proliferation of tools based on generative artificial intelligence (GAI), including the emergence of ChatGPT, has resulted in testing as a first step and implementations in further areas of business life, including marketing, as a second step. Still only a few studies have analysed and evaluated specific solutions for different areas of...
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Villa of Countess Magdalena Łosiowa, Gdynia; Villa of Czesław Antkowiak and Jerzy Prokulski, Gdynia
PublicationThe article presents one of the most interesting modern villas of Gdynia, the villa of Czesław Antkowiak and Jerzy Prokulski at 25/25a Korzeniowskiego Street in Kamienna Góra. It refers to the modernistic architecture of the villa as well as the background of its owners and the development of the new residential estate in which it was built in 1938. The author presents the oryginal plans of the building and both the old and contemporary...
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Video of LEGO Bricks on Conveyor Belt Dataset Series
PublicationThe dataset series titled Video of LEGO bricks on conveyor belt is composed of 14 datasets containing video recordings of a moving white conveyor belt. The recordings were created using a smartphone camera in Full HD resolution. The dataset allows for the preparation of data for neural network training, and building of a LEGO sorting machine that can help builders to organise their collections.
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Accurate modeling of layout parasitic to forecast EMI emitted from a DC-DC converter.
PublicationThis paper illustrates how to account for all parasitic due to the layout of a power converter (inductive and capacitive), in order to forecast electromagnetic interferences (EMI). The method is generic, and is validated here in the simple example of a DC-DC converter, realized on different technologies: insulated metal substrate (IMS), printed circuit board (PCB). In addition, several layouts aspects will be investigated. Conclusions...
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Topological invariants for equivariant flows: Conley index and degree
PublicationAbout forty years have passed since Charles Conley defined the homotopy index. Thereby, he generalized the ideas that go back to the calculus of variations work of Marston Morse. Within this long time the Conley index has proved to be a valuable tool in nonlinear analysis and dynamical systems. A significant development of applied methods has been observed. Later, the index theory has evolved to cover such areas as discrete dynamical...
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Hydration of N-Hydroxyurea from Ab Initio Molecular Dynamics Simulations
PublicationN-Hydroxyurea (HU) is an important chemotherapeutic agent used as a first-line treatment in conditions such as sickle cell disease and β-thalassemia, among others. To date, its properties as a hydrated molecule in the blood plasma or cytoplasm are dramatically understudied, although they may be crucial to the binding of HU to the radical catalytic site of ribonucleotide reductase, its molecular target. The purpose of this work...
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Przegląd systemów ładowania elektrycznych osobowych pojazdów i koncepcja dwukierunkowej ładowarki pokładowej
PublicationAktualnie trwa intensywny rozwój pojazdów elektrycznych (EV) i hybrydowych typu plug-in (PHEV) z pokładowymi bateriami akumulatorów. Badania w tej dziedzinie skupiają się na maksymalizowaniu sprawności oraz minimalizowaniu masy i objętości systemów ładowania baterii. W artykule przedstawiono podział systemów ładowania osobowych pojazdów typu EV/PHEV. Opisano systemy ładowania przewodowego z podziałem na ładowarki pokładowe i zewnętrzne, systemy...
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MODAL ANALYSIS OF REAL TIMBER FRAME HOUSES WITH DIFFERENT INSULATION MATERIALS
PublicationThe aim of this article is to present the results of a numerical modal analysis of two actual structures of timber frame buildings and the different behaviour due to the used insulation material. One model of the timber structure was filled with mineral wool, while the other with polyurethane foam. During the modal analysis, eigenvalues for both models have been determined. The results of the analysis clearly show the increase...
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Accuracy analysis of the RSSI BLE SensorTag signal for indoor localization purposes
PublicationIn this paper we describe possibility of use the RSSI signal (Radio Signal Strength Indication) from Texas Instruments SensorTag CC2650 for indoor positioning purposes. This idea is not a new but in our opinion it is possible to use SensorTags with Bluetooth LE wireless interface for positioning inside buildings in such applications as people findings in hospitals, senior come care, etc. RSSI is mostly selected as the sensor localization...
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Acoustics-related aspects of historic interior modernization projects
PublicationThe paper presents three historic interiors in which modernization projects have been carried out having an important impact on their acoustic qualities. Two of the described case studies are positive examples of solving the problem of a natural contradictions between modern technical standards and strict discipline imposed by the heritage conservation system. On the other hand, the effect of neglecting the acoustic needs when...
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The effect of laser on metal surfaces for multidisciplinary usage in material and thermal engineering
PublicationThe subject of heat transfer and cooling systems is still a matter of contention in many different fields of science and industry. Infrigidation is much more difficult than warming, and so, much more needed in more and more different devices, starting from massive industrial machinery and air conditioning in commercial buildings, up to micro and nano-surgery tools. In fact, the size of many cooling systems is still a problem. It...
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Proposed concept for the development of residential floating facilities
PublicationCurrently, a dynamic growth of interest in residential buildings located on the water can be observed in Poland. However, the lack of legal regulations, the increase in society's affluence and overpopulation in city centers lead to reflection on the development strategy that should be implemented for maritime construction. The publication presents a proposal of four development strategy concepts: aggressive,...
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Analysis of Rolling Resistance of Tires With Run Flat Insert
PublicationRun flat properties are required for tires intended for special applications like military or rescue vehicles. Run-Flat inserts make possible to drive a car or truck, with certain restrictions, also when inflation pressure is very low or non-existing (after tire damage). Rolling resistance of tires rolling the inserts increases considerably in relation to the rolling resistance of properly inflated tires. This paper presents results...
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Unusual behavior of secondary amine group as a leaving group
PublicationIn our recent project we focused on reactivity of2,2-dimethyl-4,6-dioxane-1,3-dione carbamoilo- and thiocarbamoylo- derivatives as a ketenesource. Meldrum`s acid derivatives after thermal decomposition gives substituted keteneswith stoichiometric yield, that can be trapped with various spectrum of nucleophiles likealcohols, thiols, amine, imines etc. In case of5-[3-(dimethylamino)-sulfanyl-propyliden]-2,2-dimethyl-1,3-dioxane-4,6-dione...
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Properties and determination of pesticides in fruits and vegetables
PublicationThe intensive development of agriculture means that more and more toxic organic and inorganic compounds are entering theenvironment. Because of their widespread use, stability, selective toxicity and bioaccumulation, pesticides are among the mosttoxic substances contaminating the environment. They are particularly dangerous in fruit and vegetables, by which people areexposed to them. It is therefore crucial to monitor pesticide...
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Preparation and characterization of porous scaffolds from chitosan-collagen-gelatin composite
PublicationNovel porous scaffolds composed of chitosan, collagen and gelatin were prepared and characterized. For preparing scaffolds gelatin and collagen isolated from fish skins with various physicochemical properties were used. In order to reduce preparation solubility glutaraldehyde in the amount of 1%, w/w relative to the total biopolymers weight in solution was used. All obtained biomaterials showed a homogeneous porosity. Protein polymer...
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Novel stationary phases based on asphaltenes for gas chromatography
PublicationWe present the results of investigations on the possibility of the application of the asphaltene fraction isolated from the oxidized residue from vacuum distillation of crude oil as a stationary phase for gas chromatography. The results of the investigation revealed that the asphaltene stationary phases can find use for the separation of a wide range of volatile organic compounds. The experimental values of Rohrschneider/McReynolds...
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Simultaneous determination of individual isothiocyanates in plant samples by HPLC-DAD-MS following SPE and derivatization with N-acetyl-l-cysteine
PublicationThe procedure for the isothiocyanates (ITCs) determination that involves derivatization with N-acetyl-l-cysteine (NAC) and separation by HPLC was developed. Prior to derivatization, plant ITCs were isolated and purified using solid-phase extraction (SPE). The optimum conditions of derivatization are: 500 μL of isopropanolic eluate obtained by SPE combined with 500 μL of derivatizing reagent (0.2 M NAC and 0.2 M NaHCO3 in water)...
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Synthesis and steroid sulfatase inhibitory activities of N-phosphorylated 3-(4-aminophenyl)-coumarin-7-O-sulfamates
PublicationIn the present work, we report convenient methods for the synthesis and biological evaluation of N-phosphorylated derivatives of 3-(4-aminophenyl)-coumarin-7-O-sulfamate as potential steroid sulfatase (STS) inhibitors. Their binding modes were modeled using docking techniques. The inhibitory effects of the synthesized compounds were tested on STS isolated from human placenta. All of the newly synthesised coumarin derivatives were...
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Synthesis and steroid sulfatase inhibitory activities of N-alkanoyl tyramine phosphates and thiophosphates
PublicationA series of phosphate and thiophosphate analogs based on the frameworks of N-alkanoyl tyramines have been synthesized and biologically evaluated. Their binding modes have been modeled using docking techniques. The inhibitory effects of the synthesized compounds were tested on STS isolated from the human placenta as well as the MCF-7, MDA-MB-231 and SkBr3 cancer cell lines. Most of the new STS inhibitors possessed potent activity...
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Synthesis of bicoumarin thiophosphate derivatives as steroid sulfatase inhibitors
PublicationBased on the frameworks of 7-hydroxy-2,3-dihydro-1H-cyclopenta[c]chromen-4-one, 3-hydroxy- 7,8,9,10-tetrahydro-6H-benzo[c]chromen-6-one and 3-hydroxy-8,9,10,11-tetrahydro-7H-cyclohepta[c] chromen-6-one, a series of bicoumarin thiophosphate analogs have been synthesized and biologically evaluated. Additionally, their binding modes have been modeled using docking techniques. The inhibitory properties of the synthesized compounds...
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Reduction of vibrations of steel structure models with Polymeric Bearings - experimental study
PublicationEarthquake-induced ground motions are the most severe and unpredictable threats to the structures all around the world. Therefore, designing earthquake protective systems has become an extremely challenging problem in civil engineering. Base isolation is one of the most popular and widely adopted methods of protecting structures against earthquake forces. The present paper reports the results obtained from the shaking table experimental...
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Hydration of Simple Model Peptides in Aqueous Osmolyte Solutions
PublicationThe biology and chemistry of proteins and peptides are inextricably linked with water as the solvent. The reason for the high stability of some proteins or uncontrolled aggregation of others may be hidden in the properties of their hydration water. In this study, we investigated the effect of stabilizing osmolyte–TMAO (trimethylamine N-oxide) and destabilizing osmolyte–urea on hydration shells of two short peptides, NAGMA (N-acetyl-glycine-methylamide)...
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Isolation and structure of a covalent cross-link adduct between mitomycin C and DNA
PublicationA DNA cross-link adduct of the antitumor agent mitomycin C (MC) to DNA has been isolated and characterized; the results provide direct proof for bifunctional alkylation of DNA by MC. Exposure of MC to Micrococcus luteus DNA under reductive conditions and subsequent nuclease digestion yielded adducts formed between MC and deoxyguanosine residues. In addition to the two known monoadducts, a bisadduct was obtained. Reductive MC activation...
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Force transfer and stress distribution in short cantilever deep beams loaded throughout the depth with a various reinforcement
PublicationDeep beams used as the main reinforced concrete structural elements which taking over the load and stiffening construction are often found in high-rise buildings. The architecture of these buildings is sometimes sophisticated and varied, arouse the admiration of the majority of recipients, and thus causing an engineering challenge to correctly design the structural system and force transfer. In such structures is important to shape...
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Noise Analysis of Continuous GPS Time Series of Selected EPN Stations to Investigate Variations in Stability of Monument Types
PublicationThe type of monument that a GPS antenna is placed on plays a significant role in noise estimation for each permanent GPS station. In this research 18 Polish permanent GPS stations that belong to the EPN (EUREF Permanent Network) were analyzed using Maximum Likelihood Estimation (MLE). The antennae of Polish EPN stations are placed on roofs of buildings or on concrete pillars. The analyzed data covers a period of 5 years from 2008...
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Preventing of earthquake-induced pounding between steel structures by using polymer elements – experimental study
PublicationPounding between two, or more, adjacent buildings during earthquakes has been identified as one of the reasons for substantial damage or even total collapse of colliding structures, so it has been the subject of numerous studies in the recent years. A major reason leading to interactions between adjacent, insufficiently separated structures results from the differences in their dynamic properties. A number of different methods...
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Seismic response and performance prediction of steel buckling-restrained braced frames using machine-learning methods
PublicationNowadays, Buckling-Restrained Brace Frames (BRBFs) have been used as lateral force-resisting systems for low-, to mid-rise buildings. Residual Interstory Drift (RID) of BRBFs plays a key role in deciding to retrofit buildings after seismic excitation; however, existing formulas have limitations and cannot effectively help civil engineers, e.g., FEMA P-58, which is a conservative estimation method. Therefore, there is a need to...
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Enhancing seismic performance of rigid and semi-rigid connections equipped with SMA bolts incorporating nonlinear soil-structure interaction
PublicationNowadays, using smart connections can improve the performance of buildings with some recentering features that are from the superelastic behavior of Shape Memory Alloys (SMAs). It seems that there is different rigidity between the designed connection and the real one in Steel Moment-Resisting Frames (SMRFs), which can be considered as a problematic issue due to the importance of connections in seismic performance assessment. This...
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Charakterystyka energetyczna budynków mieszkalnych wielorodzinnych w perspektywie wymagań 2017-2021
PublicationOpracowanie zawiera analizę charakterystyki energetycznej przykładowego budynku mieszkalnego wielorodzinnego przeprowadzoną w perspektywie wymagań 2017-2021 r. Wskazano w niej elementy mające wpływ na zapotrzebowanie budynku na energię użytkową, końcową i nieodnawialną energię pierwotną (wskaźnik EP). Zidentyfikowano jednocześnie możliwe problemy ze spełnieniem wymagań określonych w przepisach techniczno-budowlanych oraz wskazano...
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Lekka obudowa w nadbudowach i renowacjach
PublicationNadbudowy i renowacje – wykorzystanie technologii lekkiej obudowy. W artykule przedstawiono możliwości wykorzystania technologii lekkiej obudowy do nadbudowy i renowacji obiektów budowlanych. Opisano kolejne kroki przygotowania inwestycji dotyczącej projektowania i realizacji nadbudowy obiektu budowlanego.
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Test loadings of arch bridges
PublicationIn Poland an appreciable developement of bridge building can be seen in recent years. Arch structures are more and more common, because of the original geometrical and aesthetical form, aside with explicit structural system. Paper concerns the applied computational conceptions and researches on an example of two arch bridges. The goal of the studies is to check the correctness of the real construction work and design assumptions,...
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Rapid Assays for Specific Detection of Fungi of Scopulariopsis and Microascus Genera and Scopulariopsis brevicaulis Species
PublicationPurpose Fungi of Scopulariopsis and Microascus genera cause a wide range of infections, with S. brevicaulis being the most prevalent aetiological agent of mould onychomycosis. Proper identification of these pathogens requires sporulating culture, which considerably delays the diagnosis. So far, sequencing of rDNA regions of clinical isolates has produced ambiguous results due to the lack of reference sequences in publicly available...
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Ocena przekształceń piętrowego, ceglanego domu z dachem półpłaskim z przełomu XIX–XX wieku pod wpływem termomodernizacji na przykładzie gminy Puck, woj. pomorskie.
PublicationCeglane budynki mieszkalne z przełomu XIX i XX wieku, które stanowiły charakterystyczny element krajobrazu wsi pomorskiej, obecnie powszechnie poddawane są modernizacji w celu poprawy warunków cieplnych. Przedmiotem badania jest stan zachowania najmłodszego, historycznego typu domuw zagrodzie chłopskiej na Kaszubach – piętrowego, ceglanego domu z dachem półpłaskim. Badanie przeprowadzono na obszarze gminy Puck. Zidentyfikowano...
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Meeting Modernisms in Gdynia
PublicationThe paper focused on the architectural heritage of the city of Gdynia, in Poland, built in 1920s and 1930s. The city was established (founded) on the seaside of the Baltic Sea as the only port of Poland – a country that regained independence after Versailles Treaty. The history of the city, built from scratch is outstanding in Europe. Modernist architecture of the city is represented by buildings built for different purposes: housing,...
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Coastal Cliffs Monitoring and Prediction of Displacements Using Terrestial Laser Scanning
PublicationCoastal cliffs are very sensitive to degradation caused by erosion and abrasion. Thus, it is very important to monitor susceptibility of the cliffs in terms of slope angles and ground fall resulting from vertical morphology of the cliffs. The results could be used for example to establish the boundaries of the safe investments zone or retreat infrastructure buildings in case of real threat such as degradation of the objects of...