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Search results for: conjugate transporters
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Porty morskie jako element infrastruktury krytycznej łańcucha dostaw
PublicationW morsko-lądowych łańcuchach transportowych logistyczne procesy integracyjne przebiegają pomiędzy trzema podstawowymi ogniwami: żeglugą morską, portami morskimi i transportem zaplecza. Porty są bardzo ważnym elementem międzynarodowego łańcucha dostaw. Jako punkty początkowe i końcowe transportu morskiego są integralną częścią łańcucha transportowego, jak również miejscem działalności związanej z handlem i żeglugą morską oraz centrami...
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Identyfikacja obszarów o najsłabszym poziomie oferty publicznego transportu zbiorowego na przykładzie województwa pomorskiego
PublicationProjektowanie sieci transportu zbiorowego wymaga od projektanta wiedzy dotyczącej obecnej oferty przewozowej oraz umiejętności wyznaczenia efektu ewentualnych zmian. Obecnie wyzwanie to stoi także przed autorami planów transportowych, którzy zobowiązani są do opracowania zmian w sieci transportu zbiorowego na kilka najbliższych lat. Szczególnie istotnym etapem analizy oferty przewozowej jest identyfikacja obszarów o najsłabszej...
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New approach for determining the QoS of MP3-coded voice signals in IP networks
PublicationPresent-day IP transport platforms being what they are, it will never be possible to rule out conflicts between the available services. The logical consequence of this assertion is the inevitable conclusion that the quality of service (QoS) must always be quantifiable no matter what. This paper focuses on one method to determine QoS. It defines an innovative, simple model that can evaluate the QoS of MP3-coded voice data transported...
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Correlation between chemical composition and the presence of selected groups of bacteria in freshwater samples collected from Isfjorden and Billefjorde
PublicationThe average concentrations of pollutants in the arctic water, snow and the atmosphere are much lower than those observed in the temperate climate. Specific conditions occurring in the polar regions have apotential to accumulate the pollutants transported from other parts of the world. In this study, attempts were made to find a correlation between selected chemical components and the bacterial population. The analysis involved...
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Problematyka naukowo-badawcza w procesie integracji systemu bezpieczeństwa transportu w Polsce
PublicationPotrzeby integrowania systemów bezpieczeństwa transportu wynikają ze współczesnych wymagań cywilizacyjnych i systemowych. Warunkiem realizacji tych potrzeb jest silne wsparcie procesów integracyjnych wiedzą ukierunkowaną na typowe dla systemu transportu zjawiska powstawania wypadków i awarii, techniki badań czy potrzeby komunikowania o uzyskanych wynikach tych badań. Szczególnym wymaganiem prowadzenia badań wypadków transportowych jest...
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Nowoczesne podejście do usprawnienia systemu transportu ładunków na przykładzie działalności Zarządu Transportu w Londynie
PublicationPrzedstawiono ocenę wybranych narzędzi stosowanych przez Zarząd Transportu w Londynie (TfL) w celu poprawy jakości systemu transportu ładunków. Rozwiązania wybrano z uwagi na ich innowacyjność w zakresie dwóch podstawowych problemów: współpracy pomiędzy uczestnikami łańcucha dostaw oraz uzyskania niezbędnych informacji o charakterze przewozów realizowanych w mieście. Przeprowadzona ocena pozwala na stwierdzenie, że poprawa efektywności...
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Xanthone synthetic derivatives with high anticandidal activity and positive mycostatic selectivity index values
PublicationWith the current massive increases in drug-resistant microbial infection as well as the significant role of fungal infections in the death toll of COVID-19, discovering new antifungals is extremely important. Natural and synthetic xanthones are promising derivatives, although only few reports have demonstrated their antifungal mechanism of action in detail. Newly synthetized by us xanthone derivative 44 exhibited strong antifungal...
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Development of biocompatible iron oxide-silicon oxide core-shell nanoparticles as subcellular delivery platform for glucosamine-6-phosphate synthase inhibitors
PublicationIn order to develop the preparation of iron oxide-silica coreshell nanoparticles (CSNPs), thesis deeply explores the cetyltrimethylammonium (CTA+) directed silica coating methods of the oleic-acid capped iron oxide nanoparticles (OA-IONPs) initialized under near-neutral pH conditions. It is demonstrated that the initial alkaline hydrolysis of ethyl acetate in the presence of CTA+ and OA-IONPs induces an unusual ligand exchange...
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Romanika Okraszewska dr inż. arch.
PeopleRomanika Okraszewska, Ph.D., Eng. Arch., is an Assistant Professor at the Faculty of Civil and Environmental Engineering of Gdańsk University of Technology (GUT). Graduated from the mathematical and informatical class at the National Education Commission High School in Gdańsk. Graduated from two faculties of Gdańsk University of Technology, Architecture and Urban Planning (2002) and Management and Economics (2004). Participant...
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Financial aspects of supporting Ukrainian refugees
PublicationWarfare in Ukraine meant that in 2022 many countries, including Poland and other European, focused mainly on helping refugees from Ukraine and humanitarian transports. The assistance took on various forms - from basic humanitarian support, through in-kind help, financial and military assistance. Poland launched its humanitarian aid in the first days of the conflict. The aid provided by each country varies. It should be noted, however,...
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The Interaction of Heptakis (2,6-di-O-Methyl)-β-Cyclodextrin with Mianserin Hydrochloride and Its Influence on the Drug Toxicity
PublicationOne tetracyclic antidepressant, mianserin hydrochloride (MIA), has quite significant side effects on a patients’ health. Cyclodextrins, which are most commonly used to reduce the undesirable features of contained drugs within their hydrophobic interior, also have the potential to alter the toxic behavior of the drug. The present paper contains investigations and the characteristics of interaction mechanisms for MIA and the heptakis...
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Uwarunkowania realizacji kontrapasa autobusowego w zmiennokierunkowej organizacji ruchu
PublicationPolskie miasta wprowadzają rozwiązania mające na celu zachęcanie do korzystania z alternatywnych do podróży samochodem sposobów przemieszczania się, w tym transportem zbiorowym, co może przyczynić się do zmniejszenia zatłoczenia sieci ulicznej. Jednym z przykładów takich działań jest wprowadzenie dedykowanego zmiennokierunkowego pasa autobusowego na jednej z głównych arterii miasta Gdyni. Jest to pierwsze rozwiązanie w Polsce,...
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Management of seaport critical infrastructures of integrated sea-land transport chains
PublicationW morsko-lądowych łańcuchach transportowych logistyczne procesy integracyjne przebiegają pomiędzy trzema podstawowymi ogniwami: żeglugą morską, portami morskimi i transportem zaplecza. W tym ujęciu morsko-lądowe łańcuchy transportowe, które stanowią przestrzenno-czasową kombinację lądowych i morskich ogniw transportowych, stają się także najwyższą formą integracji portów i żeglugi z innymi gałęziami transportu, wymagającą stałego...
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An Overview of Bidirectional EV Chargers: Empowering Traction Grid-Powered Chargers
PublicationIn recent years, the number of electric vehicles has been at least doubling year after year. As a result, today electric vehicles already account for approximately 10% of the global automotive market, which positively affects environment in urbanized areas. However, to take full advantage of the EV integration it is necessary to use renewable sources for their charging; optimally place charging stations/terminals; optimally manage...
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PLANNING AND ANALYSIS OF EARTHQUAKE DISASTER RELIEF WORK IN ETHIOPIA
PublicationThis paper addresses dynamic planning and analysis of earthquake disaster relief work by analysis the disaster throughout the technical and procedural method. And combine this analysis as continues assessment for better input to investigating planning disaster for discontinuous economic growth. This implemented, considering the vulnerability and hazard analysis as a procedural analysis disaster to estimating acceptance risk leveling...
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A GPU Solver for Sparse Generalized Eigenvalue Problems with Symmetric Complex-Valued Matrices Obtained Using Higher-Order FEM
PublicationThe paper discusses a fast implementation of the stabilized locally optimal block preconditioned conjugate gradient (sLOBPCG) method, using a hierarchical multilevel preconditioner to solve nonHermitian sparse generalized eigenvalue problems with large symmetric complex-valued matrices obtained using the higher-order finite-element method (FEM), applied to the analysis of a microwave resonator. The resonant frequencies of the low-order...
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In vitro biological evaluation of a novel folic acid-targeted receptor quantum dot−β−cyclodextrin carrier for C-2028 unsymmetrical bisacridine in the treatment of human lung and prostate cancers
PublicationTraditional small-molecule chemotherapeutics usually do not distinguish tumors from healthy tissues. However, nanotechnology creates nanocarriers that selectively deliver drugs to their site of action. This work is the next step in the development of the quantum dot−β−cyclodextrin−folic acid (QD−β−CD−FA) platform for targeted and selected delivery of C−2028 unsymmetrical bisacridine in cancer therapy.Herein, we report an initial...
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Hazardous material-related propagation of the effects of train accidents in the subgrade
PublicationA large part of the transport of hazardous materials is carried out by rail. Therefore, the security of these transports is becoming increasingly important. Every catastrophe involving dangerous materials has a negative impact on the participants of the incident and the surrounding environment, because its range is generally not local. It follows that in the event of a catastrophe, its effects should be minimized and remediation...
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Imidazoacridinone-dependent lysosomal photodestruction: a pharmacological Trojan horse approach to eradicate multidrug-resistant cancers
PublicationMultidrug resistance (MDR) remains a primary hindrance to curative cancer therapy. Thus, introduction of novel strategies to overcome MDR is of paramount therapeutic significance. Sequestration of chemotherapeutics in lysosomes is an established mechanism of drug resistance. Here, we show that MDR cells display a marked increase in lysosome number. We further demonstrate that imidazoacridinones (IAs), which are cytotoxic fluorochromes,...
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Wpływ produkcji butelek z tworzyw sztucznych na środowisko naturalne. Cz. I. Zastosowanie metody oceny ReCiPe 2016 w celu identyfikacji problemów środowiskowych
PublicationDokonano oceny wpływu opakowań na środowisko naturalne. Głównym celem było przeprowadzenie analizy cyklu życia (LCA) butelki do napojów wykonanej z poli(tereftalanu etylenu) (PET). Za jednostkę funkcjonalną przyjęto łącznie 1000 szt. butelek PET o pojemności 1 L. Granica przyjętego systemu obejmowała kroki od momentu dostarczenia preform do zakładu produkcyjnego aż do ich prawidłowego ukształtowania w procesie produkcyjnym. Z systemu...
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Lodowa kraina - obszar badań dla chemika analityka. Cz. 1 - Badania z zakresu chemii analitycznej prowadzone na terenie Antarktyki
PublicationPomimo, że Antarktyka jest kontynentem wolnym od przejawów antropopresji związanej z różnymi sferami działalności człowieka dane literaturowe mogą być podstawą do stwierdzenia, że nie jest to obszar wolny od zanieczyszczeń antropogenicznych. Zanieczyszczenia, które są identyfikowane w różnych elementach środowiska Antarktyki związane są głównie z ich transportem na duże odległości oraz depozycją na tym obszarze. W pracy przedstawiono:...
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PLANOWANIE BEZPIECZNYCH I „ZIELONYCH” SYSTEMÓW KOMUNIKACYJNYCH
PublicationIn order to achieve balanced forms of urban infrastructure, which ensure comfort, safety and spatial order, when designing new solutions it is necessary to adopt a multi-facet approach which will combine everything that the local residents need but will respond harmoniously to the existing cultural landscape. It is therefore necessary to work out complex undertakings for the sake of planning and developing urban space. Coherent...
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Design and distribution of air nozzles in the biomass boiler assembly
PublicationDue to energy crisis as well as increasing pollution of the environment, renewable energy sources usage increases all over the world. These facts encouraged authors to start research over developing a uniform biomass boiler calculation model. This paper presents a design of biomass boiler assembly created for ORC (Organic Rankine Cycle) unit since these systems could achieve strong position in energy industry....
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Low-Profile Interdigitated UHF RFID Tag Antenna for Metallic Objects
PublicationThis article presents a novel miniature interdigitated ultra-high frequency (UHF) radio frequency identification (RFID) tag antenna that can be placed on metallic objects. The tag structure comprises two horizontal strip lines, each loaded with seven identical open stubs, and an integrated circuit (IC) chip connected directly to the feed lines in the middle of the structure. The perfect match to the IC chip’s impedance is realized...
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Synthesis and characterization of ruthenium and rhenium dyes with phosphonate anchoring groups
PublicationRe(L1)–Re(L3), a series of rhenium(I) tricarbonyl chloride complexes with bpy-R2 derivatives L1–L3 (bpy = 2,2′-bipyridine, R represents the substitution at the 4- and 4′-positions), and their corresponding trishomoleptic Ru(L1)3–Ru(L3)3 as well as heteroleptic ruthenium(II) complexes Ru(tbbpy)2(L1) and Ru(tbbpy)2(L2) have been synthesized and characterized. Their applicability as immobilizable metal–organic chromophores in solar...
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Photovoltaic bulk heterojunctions with interpenetrating network based on semiconducting polymers
PublicationPhotovoltaic cells are supposed to be the most common generators of useful electricity in the nearest future as they utilize inexhaustible carriers of renewable energy called photons. Despite the fact that 95% of worldwide applied photovoltaic devices are based on inorganic semiconductors the area of organic photovoltaics grows successively due to possibility of considerable reduction of manufacturing costs. Since the Heeger's...
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Fluorescent analogs of trypsin inhibitor SFTI-1 isolated from sunflower seeds-synthesis and applications
PublicationThis article describes the synthesis and enzymatic study of newly synthesized analogs of trypsin inhibitors SFTI-1 that were fluorescent labeled on their N-terminal amino groups. Two fluorescent derivatives of benzoxazole (3-[2-(4-diphenylaminophenyl) benzoxazol-5-yl]-L-alanine[(4NPh(2)) Ph] Box-Ala and 3-[2-(2', 4', 5'-trimethoxyphenyl) benzoxazol-5-yl]-l-alanine-[2,4,5-(OMe)3Ph] Box-Ala) were used as efficient fluorescent labels....
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Grzegorz Rotta dr inż.
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THE STUDY OF WATER POLLUTION OF THE LOWER VISTULA RIVER BY PLASTIC PARTICLES
PublicationSince the beginning of widespread use of plastic its consumption and production has been constantly increasing. As a result of human activity part of waste ends up in our environment and is deposited in each of the elements of the biosphere. These impurities can be in the form of large elements, small particles fragmented to macroscopic level (pellets, facial scrub grains) and the microparticles visible under a microscope. Particularly...
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Towards improved energy efficiency of future smart ships by application of advanced CFD simulations – case study
PublicationThe international trade plays crucial role in today’s globally developed world’s economy. Many people are unaware of the unimaginable volume of cargo being transported every year by oceans and seas. For most of the time invisible from land the shipping industry preserves its strong position of the most cost-efficient and environmental friendly mean of transport. However during last years the shipping industry is under great pressure...
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Wielopoziomowe modelowanie ruchu - koncepcja i doświadczenia praktyczne
PublicationDoświadczenia z ostatnich lat na obszarze województwa pomorskiego wskazują, że na obszarze województwa pomorskiego stosowane są różne narzędzia prognozowania i analiz transportowych. Stosowane modele są niekompatybilne, opracowywane przy innych założeniach i co najgorzej produkowane prognozy i wyniki analiz znacznie różnią się między sobą. Biorą to pod uwagę Katedra Inżynierii Drogowej Politechniki Gdańskiej wyszła z inicjatywą...
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Determination of ionic conductivity in the Bi-Si-O and Pb-Si-O glasses
PublicationImpedance spectroscopy measurements in various gas atmospheres were carried out in order to explain the doubts about the type of carriers and the mechanism of electrical conductivity in Bi-Si-O and Pb-Si-O glasses. In bismuth silicate glass, a typical ionic conductivity with oxygen ions as charge carriers was observed. The level of electrical conductivity of the glass at 400 °C was 5 × 10−8 S·cm−1 , with the activation energy of...
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Analiza przyczyn zużywania się (uszkadzania) szyn w zależności od warunków techniczno – eksploatacyjnych toru
PublicationDiagnostyka nawierzchni kolejowej jest istotnym elementem składowym czynników wpływających na poprawę stanu technicznego infrastruktury kolejowej w Polsce. Monitorowanie zmian zachodzących na powierzchni tocznej szyn jest bardzo ważnym elementem w kontekście poziomu bezpieczeństwa przewozów prowadzonych transportem szynowym. W artykule przedstawiono niektóre z czynników wpływające na proces degradacji powierzchni tocznej szyn w...
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Modelling and Analysis of the Positioning Accuracy in the Loading Systems of Mobile Cranes
PublicationIn this work, the authors analyse the influence of the order and range of sequential movements of a crane's working members on the accuracy of the final cargo positioning. The analysis was conducted on the basis of a specially developed method in which the authors proposed the introduction of a geometrical indicator of positioning the load in the intermediate positions (after completing each movement sequence) and in the target...
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Concentration and sources of polycyclic aromatic hydrocarbons (PAHs) and polychlorinated biphenyls (PCBs) in surface soil near a municipal solid waste (MSW) landfill
PublicationDue to a continuous demand of land for infrastructural and residential development there is a public concern about the condition of surface soil near municipal solid waste landfills. A total of 12 surface (0–20 cm) soil samples from a territory near a landfill were collected and the concentration of 16 PAHs and 7 PCB congeners were investigated in these samples. Limits of detection were in the range of 0.038–1.2 μg/kg for PAHs...
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Electrochemistry/mass spectrometry (EC/MS) for fast generation and identification of novel reactive metabolites of two unsymmetrical bisacridines with anticancer activity.
PublicationThe development of a new drug requires knowledge about its metabolic fate in a living organism, regarding the comprehensive assessment of both drug therapeutic activity and toxicity profiles. Electrochemistry (EC) coupled with mass spectrometry (MS) is an efficient tool for predicting the phase I metabolism of redox-sensitive drugs. In particular, EC/MS represents a clear advantage for the generation of reactive drug transformation...
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Glutathione-mediated conjugation of anticancer drugs: an overview of reaction mechanisms and biological significance for drug detoxification and bioactivation.
PublicationThe effectiveness of many anticancer drugs depends on the creation of specific metabolites that may alter their therapeutic or toxic properties. One significant route of biotransformation is a conjugation of electrophilic compounds with reduced glutathione, which can be non-enzymatic and/or catalyzed by glutathione-dependent enzymes. Glutathione usually combines with anticancer drugs and/or their metabolites to form more polar...
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A chemo-mechano-thermodynamical contact theory for adhesion, friction, and (de)bonding reactions
PublicationThis work presents a self-contained continuum formulation for coupled chemical, mechanical, and thermal contact interactions. The formulation is very general and, hence, admits arbitrary geometry, deformation, and material behavior. All model equations are derived rigorously from the balance laws of mass, momentum, energy, and entropy in the framework of irreversible thermodynamics, thus exposing all the coupling present in the...
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Heptaene macrolides biosynthesis by Streptomyces species
PublicationPolyene macrolides are one of the groups of secondary metabolites, generated by microorganisms belonging to the Streptomyces genus. These compounds, containing 3 - 7 conjugated double bonds systems in their molecules exhibit high antifungal activity against a broad spectrum of fungal pathogens with heptaenes demonstrating the highest antifungal potential. At the large extent, efficiency of biosynthesis of these natural products...
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A Colorimetric Microplate Assay for DNA-Binding Activity of His-Tagged MutS Protein
PublicationA simple microplate method was designed for rapid testing DNA-binding activity of proteins. The principle of the assay involves binding of tested DNA by his-tagged protein immobilized on a nickel-coated ELISA plate, following colorimetric detection of biotinylated DNA with avidin conjugated to horseradish peroxidase. The method was used to compare DNA mismatch binding activities of MutS proteins from three bacterial species. The...
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Chiral Schiff base complexes as an effective catalyst in Diels-Alder reaction
PublicationDiels Alder reaction is a very important tool in carbon-carbon bond formation. It is a cycloaddition between a conjugated diene and a second compound called dienophile. Where one or more heteroatoms are present in the diene and/or dienophile framework, the cycloaddition is called hetero-Diels-Alder reaction (HDA). The asymmetric Diels-Alder reaction is among the most powerful available methodologies for that construction of optically...
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Deep neural networks for data analysis 24/25
e-Learning CoursesThis course covers introduction to supervised machine learning, construction of basic artificial deep neural networks (DNNs) and basic training algorithms, as well as the overview of popular DNNs architectures (convolutional networks, recurrent networks, transformers). The course introduces students to popular regularization techniques for deep models. Besides theory, large part of the course is the project in which students apply...
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Disaster-Resilient Routing Schemes for Regional Failures
PublicationLarge-scale natural disasters can have a profound effect on the telecommunication services in the affected geographical area. Hence, it is important to develop routing approaches that may help in circumventing damaged regional areas of a network. This prompted the development of geographically diverse routing schemes and also of disaster-risk aware routing schemes. A minimum-cost geodiverse routing, where a minimum geographical...
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Effective Permeability of Multi Air Gap Ferrite Core 3-Phase Medium Frequency Transformer in Isolated DC-DC Converters
PublicationThe magnetizing inductance of the medium frequency transformer (MFT) impacts the performance of the isolated dc-dc power converters. The ferrite material is considered for high power transformers but it requires an assembly of type “I” cores resulting in a multi air gap structure of the magnetic core. The authors claim that the multiple air gaps are randomly distributed and that the average air gap length is unpredictable at the...
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Enhanced susceptibility to antifungal oligopeptides in yeast strains overexpressing ABC multidrug efflux pumps
PublicationPorównano podatność na działanie związków przeciwgrzybowych o strukturze oligopeptydowej oraz aminokwasowej szczepów Saccharomyces cerevisiae z usuniętymi genami kodującymi białka oporności wielolekowej oraz transformantów tych szczepów, zawierających geny CDR1, CDR2 lub MDR1, kodujące główne pompy wielolekowe Candida albicans. Rekombinowane szczepy nadprodukujące białka Cdr1p i Cdr2p wykazywały zwiększoną wrażliwość na wszystkie...
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Propagation Characteristics of Partial Discharges in an Oil-Filled Power Transformer
PublicationPower transformers are among the most important assets in the power transmission and distribution grid. However, they suffer from degradation and possible faults causing major electrical and financial losses. Partial discharges (PDs) are used to identify the insulation health status and their degradation level. PDs are incipient, low-magnitude faults caused by localized dielectric breakdown. Those activities emit signals in many...
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Proces realizacji działań dotyczących miejskiego transportu ładunków
PublicationW artykule przedstawiono strukturę proces zarządzania realizacją działań dotyczących miejskiego transportu ładunków. Proces obejmuje etapy planowania, organizacji, realizacji i kontroli, przy czym szczególną uwagę poświęcono etapowi planowania. Jest to spowodowane zidentyfikowanymi na bazie doświadczeń zagranicznych problemami w praktycznej identyfikacji problemów związanych transportem ładunków poprzez podmioty odpowiedzialne...
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Organic Pollution in Surface Waters from the Fuglebekken Basin in Svalbard, Norwegian Arctic
PublicationThe Fuglebekken basin is situated in the southern part of the island of Spitsbergen (Norwegian Arctic), on the Hornsund fjord (Wedel Jarlsberg Land). Surface water was collected from 24 tributaries (B1-B24) and from the main stream water in the Fuglebekken basin (25) between 10 July 2009 and 30 July 2009. The present investigation reveals the results of the analysis of these samples for their PAH and PCB content. Twelve of 16 PAHs...
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|Analiza zmian funkcjonowania transportu zbiorowego wynikających z budowy węzłów integracyjnych
PublicationCoraz częstszym problemem zauważalnym podczas modernizacji lub przebudowy sieci transportowej miasta jest integrowanie środków transportu. Rozwiązaniem tej sytuacji jest budowa węzłów przesiadkowych umożliwiających lepszy dostęp do transportu publicznego. Niesie to za sobą skutki w postaci modyfikacji funkcjonowania linii transportu zbiorowego, co daje możliwość poszerzenia oferty przewozowej oraz efektywnego wykorzystania potencjału...
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Linear and Nonlinear Optical Properties of Azobenzene Derivatives Modified with an (Amino)naphthalene Moiety
PublicationThe design of two-photon absorbing azobenzene (AB) derivatives has received much attention; however, the two-photon absorption (2PA) properties of bis-conjugated azobenzene systems are relatively less explored. Here, we present the synthesis of six azobenzene derivatives and three bisazobenzenes substituted (or not) at para position(s) with one or two amino group(s). Their linear and nonlinear absorption properties are studied...