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Protein overproduction alters exosome secretion in Chinese hamster ovary cells
PublikacjaDespite the abundance of available cell lines, nearly 70% of all recombinant therapeutic proteins today are produced in Chi-nese hamster ovary (CHO) cells. The impact of protein overproduction on the secretion of exosomes by CHO cells has been investigated here. Increased secretion of extracellular vesicles (EVs) by protein overexpressing CHO cells was demonstrated with protein content assay, nanoparticle tracking analysis, and...
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Protonic Ceramic Fuel Cells as novel electrochemical devices
PublikacjaProton ceramic conductors are novel materials which are interesting from the application point of view. For example, Protonic Ceramic Fuel Cells (PCFCs) is a type of a solid oxide fuel cell, which uses proton ceramic conductors as an electrolyte. Scientists are looking for the most efficient materials for these devices. In recent years main focus has been put on the search for new proton and mixed proton-electron conductors which...
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BLOOD CELLS MOLECULES AND DISEASES
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International Journal of Stem Cells
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Stem Cells Translational Medicine
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American Journal of Stem Cells
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Artificial Cells Nanomedicine and Biotechnology
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World Journal of Stem Cells
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FUEL CELLS
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Growth inhibition of cultured cancer cells by Ribes nigrum leaf extract
PublikacjaThe present article includes data on the possible selective cytotoxic effect of extract of Ribes nigrum L. growing at high Armenian landscape. For this purpose, different non-cancer (microglial BV-2 wild type (Wt), acyl-CoA oxidase 1 (ACOX1) deficient (Acox1-/-) and cancer (human colon adenocarcinoma HT29 and human breast cancer MCF7) cell lines were applied. R. nigrum leaf ethanol extract showed a growth inhibition effect towards...
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Progress in targeting tumor cells by using drug-magnetic nanoparticles conjugate.
PublikacjaTo limit the cytotoxicity of anticancer drugs against healthy cells, an appropriate carrier should be synthesized to deliver the drug to the tumor tissue only. A good solution is to anchor a magnetic nanoparticle to the molecule of the drug and to use a properly directed external magnetic field. We have shown that the improved by us synthesis of the conjugate of doxorubicin with iron-oxide magnetic nanoparticles allows a substantial...
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Comparative Proteomic Profiling of Ectosomes Derived from Thyroid Carcinoma and Normal Thyroid Cells Uncovers Multiple Proteins with Functional Implications in Cancer
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Transcriptional profile of in vitro expanded human epidermal progenitor cells for the treatment of non-healing wounds
PublikacjaBackground Epidermal progenitor cells (EPCs) have been under extensive investigation due to their increasing potential of application in medicine and biotechnology. Cultured human EPCs are used in the treatment of chronic wounds and have recently became a target for gene therapy and toxicological studies. One of the challenges in EPCs culture is to provide a high number of undifferentiated, progenitor cells displaying high viability...
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Gold nanoparticles and their coatings, their effect on cells and their interaction with radiation
PublikacjaTwo nanometre gold nanoparticles (AuNPs), bearing sugar moieties and/or polyethylene glycolamine (PEG-amine), were synthesised and evaluated for their in vitro toxicity and ability to radiosensitise cells with 220 kV and 6 MV X-rays, using four cell lines representing normal and cancerous skin and breast tissues. In addition to the observed intrinsic cancer-selective chemotoxicity, these AuNPs acted as radiosensitisers in combination with...
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New conjugates of tuftsin and muramyl dipeptide as stimulators of human monocytes-derived dendritic cells
PublikacjaMuramyl dipeptide (MDP) and tuftsin are known biologically active compound displaying a significant influence on various cell populations of innate immune response. MDP, as a fragment of bacterial cell wall, stimulates not only macrophages and monocytes, but also dendritic cells. In contrast, little is known about tuftsin influence on these cells. Therefore it seemed vital to access whether tuftsin or its derivatives conjugated...
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Assessment of Fuel Cells’ State of Health by Low-Frequency Noise Measurements
PublikacjaWe proposed applying low-frequency (flicker) noise in proton-exchange membrane fuel cells under selected loads to assess their state of health. The measurement set-up comprised a precise data acquisition board and was able to record the DC voltage and its random component at the output. The set-up estimated the voltage noise power spectral density at frequencies up to a few hundred mHz. We observed the evolution of the electrical...
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Materials for Mediator-free Electron Transfer in the Enzymatic Electrodes of Biobatteries and Biofuel Cells
PublikacjaWe present functionalization of single-walled carbon nanotubes (SWCNTs) and their application in the enzymatic fuel cells construction. SWCNTs were covalently modified with different types of aromatic moieties. Free radical reaction was employed to create direct carbon-carbon bond between moiety and SWCNTs. In second approach functionalization takes place through amide bonding. Functionalized SWCNTs were characterized by spectroscopy...
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Novel cobalt-free BaFe1−xGdxO3−δ perovskite membranes for oxygen separation
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Influence of pore formers on electrical properties of CaTi0.9Fe0.1O3-δ perovskite-type ceramics
PublikacjaPorous CaTi0.9Fe0.1O3-δ (CTF) perovskites were synthesized by the standard solid state method at different sintering temperatures with carbon black (CB), corn starch (CS) and potato starch (PS) as pore-forming agents. The ceramic samples of porosity between 9% and 42% with 5 - 40 μm pore sizes, were obtained by a 6 h sintering at either 1130º C or 1200º C of precursor powder prepared at 1470º C. X-ray diffraction analysis proved...
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Photovoltaic solar energy development in the Baltic Sea Region
PublikacjaInformacje zawarte w tym artykule odzwierciedlają różnorodność rozwoju technologii fotowoltaicznych i różnorodność etapów realizacji PV przez kraje regionu Morza Bałtyckiego (Dania, Finlandia, Niemcy, Łotwa, Litwa, Szwecja, Polska, Estonia).
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Spray pyrolysis of doped-ceria barrier layers for solid oxide fuel cells
PublikacjaGadolinium doped ceria (Ce0.8Gd0.2O2 − x-CGO) layer fabricated by spray pyrolysis is investigated as the diffusion barrier for solid oxide fuel cell. It is deposited between the La0.6Sr0.4FeO3 − δ cathode and the yttria stabilized zirconia electrolyte to mitigate harmful interdiffusion of elements. The parameters of the fabrication process are linked to the measured area specific resistances of the symmetrical cells and the efficiency...
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DIFFRACTION PHASE MICROSCOPY FOR OBSERVATION ON RED BLOOD CELLS FLUCTUATION
PublikacjaNowadays there is quite huge need for more and more precise and effective fast diagnostics methods in hematology diseases. One of the most important blood components are erythrocytes – RBCs (Red Blood Cells). Due to their size they are easy to observe using microscopy. It is commonly known that the shape and lifetime of RBCs allows for early disease identification. Authors present special measurement system for RBCs fluctuations observation...
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Enhanced solar light photocatalytic performance of Fe-ZnO in the presence of H2O2, S2O82−, and HSO5− for degradation of chlorpyrifos from agricultural wastes: Toxicities investigation
PublikacjaThis study reported Fe doped zinc oxide (Fe-ZnO) synthesis to degrade chlorpyrifos (CPY), a highly toxic organophosphate pesticide and important sources of agricultural wastes. Fourier transform infrared, X-ray diffraction, scanning electron microscope, and energy-dispersive X-ray spectroscopic analyses showed successful formation of the Fe-ZnO with highly crystalline and amorphous nature. Water collected from agricultural wastes...
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Characterization of immobilized Escherichia coli cells transformed by β-galactosidase gene from Pyrococcus woesei
PublikacjaThermostable β-galactosidase from Escherichia coli transformant containing theenzyme gene from Pyrococcus woesei was immobilized on alginate gel.The benefits of using whole bacterial cells not only exclude expensive, laborious proteinisolation and purification but also stabilize enzymes by cytosol components. Increase inproductivity of enzyme can be achieved by cells permeabilization. To increase permeability ofcytoplasmic membrane...
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Effect of sintering temperature on electrochemical performance of porous SrTi1-xFexO3-δ (x = 0.35, 0.5, 0.7) oxygen electrodes for solid oxide cells
PublikacjaThis work evaluates the effects of the sintering temperature (800 °C, 900 °C, 1000 °C) of SrTi1-xFexO3-δ (x = 0.35, 0.5, 0.7) porous electrodes on their electrochemical performance as potential oxygen electrode materials of solid oxide cells. The materials were prepared by a solid-state reaction method and revealed the expected cubic perovskite structure. After milling, the powders were characterised by a sub-micrometre particle...
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Bortezomib induces methylation changes in neuroblastoma cells that appear to play a significant role in resistance development to this compound
PublikacjaThe anticancer activity of bortezomib (BTZ) has been increasingly studied in a number of indications and promising results for the use of this treatment have been shown in neuroblastoma. As BTZ treatment is usually administered in cycles, the development of resistance and side effects in patients undergoing therapy with BTZ remains a major challenge for the clinical usage of this compound. Common resistance development also means...
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Observation on red blood cells fluctuations by diffraction phase microscopy
PublikacjaNowadays there is quite huge need for more and more precise and effective fast diagnostics methods in hematology diseases. One of the most important blood components are erythrocytes – Red Blood Cells (RBCs). Due to their size they are easy to observe using microscopy. It is commonly known that the shape and lifetime of RBCs allows for early disease identification. Authors present special measurement system for RBCs fluctuations...
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Dibutyl phthalate disrupts conserved circadian rhythm in Drosophila and human cells
PublikacjaPeople are constantly exposed to phthalates, due to their common use in the production of plastics, pharmaceuticals, cosmetics and skin care products. The ability of phthalates to disrupt endocrine signaling, leading to developmental, reproductive and metabolic defects, has been studied, yet how phthalates interfere with these biological functions is still unclear. To uncover DBP interacting molecular pathways, we raised Drosophila...
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Anticancer Imidazoacridinone C-1311 is Effective in Androgen-Dependent and Androgen-Independent Prostate Cancer Cells
PublikacjaAndrogen receptor (AR) plays a crutial role in prostate cancer (PCa) development and metastasis. Here, we reported potent anti-PCa activity of a small molecule imidazoacridinone C-1311. In AR-positive PCa cells, C-1311 was found to inhibit the transcriptional activity of AR uncovering a novel mechanism that may be relevant for its anticancer effect. Mechanistically, C-1311 decreased AR binding to prostate-specific antigen (PSA)...
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Status report on high temperature fuel cells in Poland – Recent advances and achievements
PublikacjaThe paper presents recent advances in Poland in the field of high temperature fuel cells. The achievements in the materials development, manufacturing of advanced cells, new fabrication techniques, modified electrodes and electrolytes and applications are presented. The work of the Polish teams active in the field of solid oxide fuel cells (SOFC) and molten carbonate fuel cell (MCFC) is presented and discussed. The review is oriented...
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Activity of Patents in Fuel Cells and Hydrogen Production in the Context of Passenger Car Fleet in the V4 Countries
PublikacjaThe hydrogen market in the world today is capable ovule and em-pirical evidence on activity of patents in fuel cells and hydrogen production islimited so far. Patent applications in zero-emission mobility in the aspect of fuelcells include: DAFC/DMFC&DMFC, PEMFC, SOFC, AFC, PAFC. As for thepatents relating to the hydrogen production, they concern low carbon, electrol-ysis and inorganic. The purpose of the study was to investigate...
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Treatment innovation using solar/UV In book: The Treatment of Pharmaceutical Wastewater: Innovative Technologies and the Adaptation of Treatment Systems
PublikacjaSince ancient times, sunlight irradiation has been widely used for water purification. Apart from solar water disinfection techniques, UV irradiation is of particular interest when considering the photodegradation of various classes of emerging pollutants. Pharmaceutically active compounds are one of the largest classes of micropollutants. The main sources of these contaminants in wastewater and aqueous environments are households,...
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Synthesis, characterization, and application of 2D/2D TiO2-GO-ZnFe2O4 obtained by the fluorine-free lyophilization method for solar light-driven photocatalytic degradation of ibuprofen
PublikacjaIn this study, we report the potential of 2D/2D TiO2- GO-ZnFe2O4 photocatalyst obtained using the fluorine-free lyophilization technique for the degradation of ibuprofen belonging to the group of active pharmaceutical ingredients (API). The improved ibuprofen degradation under simulated solar light was achieved in the presence of a composite of 2D TiO2 combined with GO and embedded ZnFe2O4, which additionally provides superparamagnetic...
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Fabrication of solid oxide fuel cell supported on speciallyperformed ferrite-based perovskite cathode
PublikacjaW pracy przedstawiono warunki technologiczne niezbedne do wytworzenia tlenkowego ogniwa paliwowego na elencie nośnym z materiału perowskitowego LSF. Jako elektrolit stosowana była ceramika z tlenku ceru. Między innymi badany były właściwości elektryczne zarówno materiału katodowego jak i ogniwa.
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Quantum Dots as a Good Carriers of Unsymmetrical Bisacridines for Modulating Cellular Uptake and the Biological Response in Lung and Colon Cancer Cells
PublikacjaNanotechnology-based drug delivery provides a promising area for improving the efficacy of cancer treatments. Therefore, we investigate the potential of using quantum dots (QDs) as drug carriers for antitumor unsymmetrical bisacridine derivatives (UAs) to cancer cells. We examine the influence of QD–UA hybrids on the cellular uptake, internalization (Confocal Laser Scanning Microscope), and the biological response (flow cytometry...
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Role of size scale of ZnO nanoparticles and microparticles on toxicity toward bacteria and osteoblast cancer cells
PublikacjaThe specific role of size scale, surface capping, and aspect ratio of zinc oxide (ZnO) particles on toxicity toward prokaryotic and eukaryotic cells was investigated. ZnO nano and microparticles of controlled size and mor- phology were synthesized by wet chemical methods. Cytotoxicity toward mammalian cells was studied using a human osteoblast cancer cell line and antibacterial activity using Gram-negative bacteria (Escherichia...
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Modulation of CYP3A4 activity and induction of apoptosis, necrosis and senescence by the antitumor imidazoacridinone C-1311 in human hepatoma cells
PublikacjaThere is increasing evidence that the expression level of drug metabolic enzymes affects the final cellular response following drug treatment. Moreover, anti-tumour agents may modulate enzymatic activity and/or cellular expression of metabolic enzymes in tumour cells. We investigated the influence of CYP3A4 overexpression on the cellular response induced by the anti-tumour agent C-1311 in hepatoma cells. C-1311-mediated CYP3A4...
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Photovoltaic module temperature stabilization with the use of phase change materials
PublikacjaThe worldwide growth of photovoltaics (PVs) has formed an exponential curve for more than four decades. During this period of time, PVs have evolved from a pure niche market of small-scale applications towards becoming a mainstream electricity source. The influence of temperature on the electrical parameters of crystalline silicon solar cells and solar modules is well described in the literature. In order to diminish these effects,...
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Hydrogen evolution on the reduced TiO2 under simulated solar lamp
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Investigation of the outdoor illuminated and air-cooled silicon solar cell
PublikacjaPrzedstawiono metodę wyznaczania współczynnika nieidealności ogniwa słonecznego w oparciu o zmiany napięcia otwartego obwodu w funkcji nasłonecznienia. Zastosowano chłodzenie ogniwa przy użyciu radiatora i strumienia powietrza celem utrzymania jego temperatury na stałym poziomie podczas eksperymentu. Omówiono wpływ nasłonecznienia i temperatury ogniwa na kształt charakterystyki i położenie punktu maksymalnej mocy.
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Solar Photocatalytic Degradation of Sulfamethoxazole by TiO2 Modified with Noble Metals
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Annual variations in the solar energy conversion efficiency in will coppice stand.
PublikacjaMonitorowano produkcyjność plantacji wiklinowych w Uppsali w Szwecji w latach 1985-1994. Okazało się, że największa sprawność przetwarzania energii słonecznej w biomasę ma miejsce w drugim i trzecim roku uprawy wiklinowej (około 1%), natomiast w pierwszym i w czwartym roku sprawność ta jest 2 razy niższa i wynosi około 0,5%. Dyskutuje się przyczyny takiej sytuacji.
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Enhancement of self-trapped excitons and near-infrared emission in Bi3+/Er3+ co-doped Cs2Ag0.4Na0.6InCl6 double perovskite
Dane BadawczeErbium (Er) complexes are used as optical gain materials for signal generation in the telecom C-band at 1540 nm, but they need a sensitizer to enhance absorption. Na+ substitution for Ag+ and Bi3+ doping at the In3+ site is a possible strategy to enhance the broadband emission of Cs2AgInCl6, which could be used as a sensitizer for energy transfer to...
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A novel in vitro assay for assessing efficacy and toxicity of antifungals using human leukaemic cells infected with Candida albicans
PublikacjaAims: This study describes a novel in vitro assay that simultaneously determines antifungal efficiency and host cell toxicity using suspensions of human leukaemic cells (HL-60) infected with Candida albicans. Methods and Results: The effect of Candida infection on host cell viability was evaluated by the microscopy of trypan blue-stained cells and lactate dehydrogenase (LDH) activity. The in vitro ‘drug potency assay’ utilized...
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The Influence of External Load on the Performance of Microbial Fuel Cells
PublikacjaIn this work, the effect of the external load on the current and power generation, as well as on the pollutant removal by microbial fuel cells (MFCs), has been studied by step-wise modifying the external load. The load changes included a direct scan, in which the external resistance was increased from 120 Ω to 3300 Ω, and a subsequent reverse scan, in which the external resistance was decreased back to 120 Ω. The reduction in the...
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Foetal haemoglobin-blood cells (F-cells) as a feature of embryonic tumours (blastomas)
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Performance of microbial fuel cells operated under anoxic conditions
PublikacjaNowadays, microbial fuel cells (MFC) stand up as a promising renewable energy source. Due to the ability of the MFC to oxidize a wide spectrum of substrates, wastewater seems to be one of the most interesting fuels. Unfortunately, wastewater could contain electron acceptors such as nitrate, which could interfere with the electrical performance of the MFC. In this work, the influence of oxidised nitrogen forms on the electricity...
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NANOCRYSTALLINE CATHODES FOR SOLID OXIDE FUEL CELLS MADE OF NOBLE METALS
PublikacjaCathodes for solid oxide fuel cells prepared by the infiltration method at 600 °C are presented. The infiltration method allows to produce stable, nanostructured electrodes. Cathodes were prepared using gold, platinum, La2NiO4+δ (L2N) and La0.6Sr0.4Co0.2Fe0.8O3 δ (LSCF). Symmetrical cathode/electrolyte/cathode samples were prepared and examined with SEM microscopy and electrochemical impedance spectroscopy. Despite successful deposition...
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Investigation of catalytic layers on anode for solid oxide fuel cells operating with synthetic biogas
PublikacjaIn this paper solid oxide fuel cells operating with dry synthetic biogas have been examined. In order to increase their stability the layers of CuO-CeO2, Cu1.3Mn1.7O4 and Y0.08Sr0.92Ti0.8Fe0.2O3 -δ have been deposited on the Ni-YSZ anode site. These layers should catalyze the internal biogas reforming and prevent the carbon deposition on the anode site. It has been found that CuO-CeO2 and Cu1.3Mn1.7O4 catalysts led to an increase...
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Human Induced Pluripotent Stem Cell-Derived Microvesicles Transmit RNAs and Proteins to Recipient Mature Heart Cells Modulating Cell Fate and Behavior
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Effective Drug Concentration and Selectivity Depends on Fraction of Primitive Cells
PublikacjaPoor efficiency of chemotherapeutics in the eradication of Cancer Stem Cells (CSCs) has been driving the search for more active and specific compounds. In this work, we show how cell density-dependent stage culture profiles can be used in drug development workflows to achieve more robust drug activity (IC50 and EC50) results. Using flow cytometry and light microscopy, we characterized the cytological stage profiles of the HL-60-,...
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Journal of Stem Cells & Regenerative Medicine
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Stem Cells and Cloning-Advances and Applications
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ARTIFICIAL CELLS BLOOD SUBSTITUTES AND BIOTECHNOLOGY
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Optimization of Transport Properties of A-Site Ordered LnBa1-xSrxCo2-yFeyO5+ Perovskite-Type Cathode Materials
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Perovskite-type KTaO3–reduced graphene oxide hybrid with improved visible light photocatalytic activity
PublikacjaNovel rGO–KTaO3 composites with various graphene content were successfully synthesized using a facile solvothermal method which allowed both the reduction of graphene oxide and loading of KTaO3 nanocubes on the graphene sheets. The as-prepared photocatalysts were characterized by X-ray diffraction (XRD), transmission electron microscopy (TEM), scanning electron microscopy (SEM) with energy dispersive X-ray analysis (EDX), Fourier...
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Efficiency of exciton splitting in organic photovoltaic cells within EQE spectrum
PublikacjaThe paper presents a procedure of estimating the efficiency of exciton splitting at ED/EA interface. The procedure consists in evaluation of splitting of excitons into electron-hole pairs on the basis of the external quantum efficiency spectra of planar cells and spectra of absorbance of active organic layers. The fitting parameters are the exciton splitting probabilities at ED/EA interface. The presented procedure was applied...
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Magnetically recyclable TiO2/MXene/MnFe2O4 photocatalyst for enhanced peroxymonosulphate-assisted photocatalytic degradation of carbamazepine and ibuprofen under simulated solar light
PublikacjaIn this study, a novel TiO2/Ti3C2/MnFe2O4 magnetic photocatalyst with dual properties, enabling (i) improved photocatalytic degradation with PMS activation under simulated solar light and (ii) magnetic separation after the degradation process in an external magnetic field was developed and applied for the efficient photodegradation pharmaceutically active compounds (PhACs) frequently present in wastewater and surface waters worldwide. MXene...
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Solar radiation (PAR, UV-B and UV-A) reaching the sea surface - Gdańsk Deep (2001-2005)
Dane BadawczeSolar radiation reaching the sea surface was measured in spring (2001, 2003, 2005) and autumn (2002, 2004). For measurements of the photosynthetic active radiation - PAR (400-700 nm), the Ejkelkamp SKP 210 / I 0896 13595 sensor was used, the UV-B radiation (280-315 nm) was measured with the Ejkelkamp SKU 430 0497 14854 sensor, while UV-A (315- 380 nm)...
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A compact seven-section rat-race hybrid coupler incorporating pbg cells
PublikacjaA conventional rat-race coupler has been doubly miniaturized: (i) characteristic impedances and electrical lengths of microstrip sections have been adequately modified as the first step of size reduction and (ii) T-shaped PBG cells have been implemented to diminish strip section length as the second step of circuit rat-race couplerminiaturization. The experimental results show good agreement with theoretical characteristics. Furthermore,...
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Expression of goose parvovirus whole VP3 protein and its epitopes in Escherichia coli cells
PublikacjaThe aim of this study was the expression of goose parvovirus capsid protein (VP3) and its epitopes in Escherichia coli cells. Expression of the whole VP3 protein provided an insufficient amount of protein. In contrast, the expression of two VP3 epitopes (VP3ep4, VP3ep6) in E. coli, resulted in very high expression levels. This may suggest that smaller parts of the GPV antigenic determinants are more efficiently expressed than the...
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Effects of Salvia officinalis and Thymus vulgaris on oxidant-induced DNA damage and antioxidant status in HepG2 cells
PublikacjaSalvia officinalis (SO) and Thymus vulgaris (TV) are medicinal plants well known for their curative powers. However, the molecular mechanisms responsible for these abilities of sage and thyme have not been fully understood yet. In this study we investigated the composition and the quantitative estimation of plant extracts, the protective effects of plant extracts against hydrogen peroxide- and 2,3-dimethoxy-1,4 naphthoquinone-induced...
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Applied Solar Energy (English translation of Geliotekhnika)
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Neural Networks in the Diagnostics Process of Low-Power Solar Plant Devices
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Outdoor I-V measurements of air-cooled silicon solar cell
PublikacjaStosując radiator aluminiowy i przpływ powietrza z obu stron krystalicznego krzemowego ogniwa słonecznego osiągnięto skuteczne odprowadzanie ciepła i schłodzenie do temperatury otoczenia. Nową metodą (przy oświetleniu ogniwa i mniejszym napięciu) wyznaczono rezystancję szeregową i współczynnik nieidealności mierzonej charakterystyki I-V.
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Temporal and spatial complementarity of wind and solar resources in Lower Silesia (Poland)
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Low frequency noise and DLTS as silicon solar cell characterization tools
PublikacjaPraca zawiera wyniki pomiarów DLTS próbek o powierzchni 1 mm2 krzemowych baterii słonecznych wykazujących znaczne niejednorodności wykryte za pomocą metody LBIV (Light Beam Induced Voltage). Wyniki pomiarów charakterystyk stałoprądowych oraz szumowych tych próbek zostały także przedstawione.
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The low energy house using an air solar collector - a case study
PublikacjaCelem tego artykułu jest przedstawienie możliwości ogrzewania i chłodzenia domu jednorodzinnego przy wykorzystaniu słonecznych kolektorów powietrznych. W analizie uwzględniono dom energooszczędny, którego wskaźnik sezonowego zapotrzebowania na ciepło wynosi 40kWh/m2/a. Do obliczeń przyjęto kolektory powietrzne dostępne na rynku o powierzchni 60m2 i wydajności wynoszącej 70%. W analizowanym budynku występuje prawie pełne pokrycie...
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Implementation of DEIS for reliable fault monitoring and detection in PEMFC single cells and stacks
PublikacjaDynamic Electrochemical Impedance Spectroscopy (DEIS) was presented as novel method for diagnostic and monitoring of PEMFC stack and single cells operation. Impedance characteristics were obtained simultaneously with current - voltage characteristics for stack and each individual cell. Impedance measurements were performed in galvanodynamic mode. It allowed to compare performance of each cell and identification of faulty cell operation...
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The antitumor compound triazoloacridinone C-1305 inhibits FLT3 kinase activity and potentiates apoptosis in mutant FLT3-ITD leukemia cells.
PublikacjaAim: FMS-like receptor tyrosine kinase (FLT3) is expressed in some normal hematopoietic cell types and plays an important role in the pathogenesis of acute myeloid leukemia (AML). In this study, we examined the effects of triazoloacridinone C-1305, an antitumor compound, on AML cells with different FLT3 status in vitro. Methods: A panel of human leukemic cell lines with different FLT3 status was used, including FLT3 internal tandem...
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CeCu2O4 as a functional layer on solid oxide fuel cells for synthetic biogas reforming
PublikacjaSolid Oxide Fuel Cells (SOFC) are one of the most promising electrochemical devices, which can convert chemical energy to the electrical energy these days. Their ability to work with different kind of fuel makes them noteworthy. SOFC can work with biogas. The problem arises when solid carbon starts to be deposited in anode. That leads to degradation of fuel cell. Simple solution is to apply catalytic functional layer, which is...
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Design and characterization of apatite La9.8Si5.7Mg0.3O26±δ-based micro-tubular solid oxide fuel cells
PublikacjaIn this study, electrolyte-supported (Cell A) and anode-supported (Cell B) micro-tubular solid oxide fuel cells (SOFCs) based on the La9.8Si5.7Mg0.3O26±δ (LSMO) electrolyte is built through an extrusion and dip-coating processes. The formulations and process conditions for these cells are established and optimized. Both cell configurations show no visible delamination or cracking, and reaction zones and inter-diffusion of any species...
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Applications of calcium electroporation to effective apoptosis induction in fibrosarcoma cells and stimulation of normal muscle cells
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Performance and Stability in H2S of SrFe0.75Mo0.25O3-δ as Electrode in Proton Ceramic Fuel Cells
PublikacjaThe H2S-tolerance of SrFe0.75Mo0.25O3-δ (SFM) electrodes has been investigated in symmetric proton ceramic fuel cells (PCFC) with BaZr0.8Ce0.1Y0.1O3-δ (BZCY81) electrolyte. The ionic conductivity of the electrolyte under wet reducing conditions was found to be insignificantly affected in the presence of up to 5000 ppm H2S. The fuel cell exhibited an OCV of about 0.9 V at 700 °C, which dropped to about 0.6 V and 0.4 V upon exposure...
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In Vitro Studies on Nanoporous, Nanotubular and Nanosponge-Like Titania Coatings, with the Use of Adipose-Derived Stem Cells
PublikacjaIn vitro biological research on a group of amorphous titania coatings of different nanoarchitectures (nanoporous, nanotubular, and nanosponge-like) produced on the surface of Ti6Al4V alloy samples have been carried out, aimed at assessing their ability to interact with adipose-derived mesenchymal stem cells (ADSCs) and affect their activity. The attention has been drawn to the influence of surface coating architecture and its physicochemical...
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Chemical diffusion and surface exchange in selected Ln–Ba–Sr–Co–Fe perovskite-type oxides
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Targeting of FLT3-ITD kinase contributes to high selectivity of imidazoacridinone C-1311 against FLT3-activated leukemia cells
PublikacjaDrugs targeting receptor tyrosine kinase FLT3 are of particular interest since activating FLT3-internal tandem duplication (ITD) mutations abundantly occur in fatal acute myeloid leukemias (AMLs). Imidazoacridinone C-1311, a DNA-reactive inhibitor of topoisomerase II, has been previously shown to be a potent and selective inhibitor of recombinant FLT3. Here, we expand those findings by studying its effect on leukemia cells with...
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Antitumor 1-nitroacridine derivative C-1748 induces significant apoptosis in pancreatic cancer cells.
PublikacjaPancreatic cancer is the fifth leading cause of cancer death and has the lowest survival rate of any solid cancer in the industrial countries. The poor prognosis of pancreatic cancer results from its tendency for late presentation, aggressive invasion, early metastasis, and resistance to chemotherapy. Gemcitabine still remains the best chemotherapeutic agent available for the treatment of advanced pancreatic cancer. However, gemcitabine...
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Optimization of the Relative Humidity of Reactant Gases in Hydrogen Fuel Cells Using Dynamic Impedance Measurements
PublikacjaWater management is a key factor affecting the efficiency of proton exchange membrane fuel cells (PEMFCs). The currently used monitoring methods of PEMFCs provide limited information about which processes or components that humidity has a significant impact upon. Herein, we propose the use of a novel approach of impedance measurements using a multi-sinusoidal perturbation signal, which enables impedance measurements under dynamic...
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Inhibition of T-type calcium channel disrupts Akt signaling and promotes apoptosis in glioblastoma cells.
PublikacjaGlioblastoma multiforme (GBM) are brain tumors that are exceptionally resitant to both radio- and chemotherapy regimens and novel approaches to treatment are needed. T-type calcium channels are one type of low voltage-gated channel (LVCC) involved in embryonic cell proliferation and differentiation; however they are often over-expressed in tumors, including GBM. In this study, we found that inhibition of T-type Ca channels in GBM...
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The impact of air humidity on the operation of proton exchange membrane fuel cells determined using dynamic electrochemical impedance spectroscopy
PublikacjaThis paper describes the changes in the fuel cell impedance across a range of current loads and humidity changes. The changes of each equivalent circuit parameters representing specific processes occurring in fuel cells, as a function of humidity and current changes, were determined. Within the combined scope of current and humidity, the optimal working conditions of the cells were determined, corresponding to the lowest impedance...
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CYP3A4 overexpression enhances apoptosis induced by anticancer agent imidazoacridinone C-1311, but does not change the metabolism of C-1311 in CHO cells
PublikacjaWe examine whether CYP3A4 overexpression influences the rate and pattern of antitumor imidazoacridinone C-1311 metabolism, in relation to the impact of this overexpression on cell cycle progression and final cellular response of CHO cells following C-1311 treatment. Methods: Three CHO cell lines: CHO-WT, wild type, CHO-HR, overexpressing cytochrome P450 reductase (CPR) and CHO-HR-3A4, coexpressing CPR and CYP3A4 were applied....
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CYP3A4-dependent cellular response does not relate to CYP3A4-catalysed metabolites of C-1748 and C-1305 acridine antitumor agents in HepG2 cells
PublikacjaHigh CYP3A4 expression sensitizes tumor cells to certain antitumor agents while for others it can lower their therapeutic ef fi cacy. We have elucidated the in fl uence of CYP3A4 overexpression on the cellular response induced by antitumor acridine derivatives, C-1305 and C-1748, in two hepatocellular carcinoma (HepG2) cell lines, Hep3A4 stably transfected with CYP3A4 isoenzyme, and HepC34 expressing empty vector. The compounds...
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The imidazoacridinone C-1311 induces p53-dependent senescence or p53-independent apoptosis and sensitizes cancer cells to radiation
PublikacjaC-1311 is a small molecule, which has shown promise in a number of preclinical and clinical studies. However, the biological response to C-1311 exposure is complicated and has been reported to involve a number of cell fates. Here, we investigated the molecular signaling which determines the response to C-1311 in both cancer and non-cancer cell lines. For the first time we demonstrate that the tumor suppressor, p53 plays a key role...
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Chromatographic analyses of Lavandula angustifolia and Rosmarinus officinalis extracts and their biological effects in mammalian cells and cell-free systems
PublikacjaKnowledge of biological properties of natural compounds allows to understand their therapeutic value, efficacy and security. We investigated: composition of Lavandula angustifolia (LA) and Rosmarinus officinalis (RO) extracts, their antioxidant capacity, cytotoxicity and genotoxicity, their DNA-protective potential against DNA damage induced in hamster V79 cells by several genotoxins or in plasmid DNA by Fe2+ ions and activity...
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Deposition and Electrical and Structural Properties of La0.6Sr0.4CoO3 Thin Films for Application in High-Temperature Electrochemical Cells
PublikacjaLow-temperature deposition of electroceramic thin films allows the construction of new devices and their integration with existing large-scale fabrication methods. Developing a suitable low-cost deposition method is important to further advance the development of microdevices. In this work, we deposited a 1-lm-thick La0.6Sr0.4CoO3d (LSC) perovskite with high electrical conductivity on sapphire substrates at 400C and analyzed its...
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c-Myc Protein Level Affected by Unsymmetrical Bisacridines Influences Apoptosis and Senescence Induced in HCT116 Colorectal and H460 Lung Cancer Cells
PublikacjaUnsymmetrical bisacridines (UAs) are highly active antitumor compounds. They contain in their structure the drugs previously synthesized in our Department: C-1311 and C-1748. UAs exhibit different properties than their monomer components. They do not intercalate to dsDNA but stabilize the G-quadruplex structures, particularly those of the MYC and KRAS genes. Since MYC and KRAS are often mutated and constitutively expressed in cancer...
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Design and experimental validation of a single-stage PV string inverter with optimal number of interleaved buck-boost cells.
PublikacjaIncreasing converter power density is a problem of topical interest. This paper discusses an interleaved approach of the efficiency increase in the buck-boost stage of an inverter with unfolding circuit in terms of losses in semiconductors, output voltage ripples and power density. Main trends in the power converter development are reviewed. A losses model was designed and used for the proposed solution to find an optimal number...
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Synthetic lipopeptides as potential topical therapeutics in wound and skin care: in vitro studies of permeation and skin cells behaviour
PublikacjaSeveral Gly-His-Lys analogues were obtained to investigate their antimicrobial properties. Three lipophilic analogues with the structure numbering 1b, 2b, 4b, exhibit significant effect against bacteria and were selected for in vitro evaluation of skin cells behaviour. In the present studies, an in vitro model of wound repair, proliferative cell staining, and tracking of living cells were used. Cell proliferation and cell migration,...
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Foliate-Targeting Quantum Dots-β-Cyclodextrin Nanocarrier for Efficient Delivery of Unsymmetrical Bisacridines to Lung and Prostate Cancer Cells
PublikacjaTargeted drug delivery by nanocarriers molecules can increase the efficiency of cancer treatment. One of the targeting ligands is folic acid (FA), which has a high affinity for the folic acid receptors, which are overexpressed in many cancers. Herein, we describe the preparation of the nanoconjugates containing quantum dots (QDs) and β-cyclodextrin (β-CD) with foliate-targeting properties for the delivery of anticancer compound...
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DNA-damaging imidazoacridinone C-1311 induces autophagy followed by irreversible growth arrest and senescence in human lung cancer cells
PublikacjaImidazoacridinone 5-diethylaminoethylamino-8-hydroxyimidazoacridinone (C-1311) is an antitumor inhibitor of topoisomerase II and FMS-like tyrosine kinase 3 receptor. In this study, we describe the unique sequence of cellular responses to C-1311 in human non-small cell lung cancer (NSCLC) cell lines, A549 and H460. In A549 cells, C-1311 (IC80 = 0.08 µM) induced G1 and G2/M arrests, whereas H460 cells (IC80 = 0.051 µM) accumulated...
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PARP inhibition potentiates the cytotoxic activity of C-1305, a selective inhibitor of topoisomerase II, in human BRCA1-positive breast cancer cells
PublikacjaTwo cellular proteins encoded by the breast and ovarian cancer type 1 susceptibility (BRCA1 and BRCA2) tumor suppressor genes are essential for DNA integrity and the maintenance of genomic stability.Approximately 5-10% of breast and ovarian cancers result from inherited alterations or mutations in these genes.Remarkably, BRCA1/BRCA2-deficient cells are hypersensitive to selective inhibition of poly(ADPribose) polymerase 1 (PARP-1),...
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Wind and Solar Power Plant End-of-Life Equipment: Prospects for Management in Ukraine
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Operational Properties Investigation of The Flat-Plate Solar Collector with Poliuretane Foam Insulation
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Estimation of Solar Energy Influx to the Sea in the Light of Fast Satellite Technique Development
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Photocatalytic water disinfection under the artificial solar light by fructose-modified TiO2
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Photocatalytic Water Disinfection under Solar Irradiation by d-Glucose-Modified Titania
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Electricity generation from rapeseed straw hydrolysates using microbial fuel cells
PublikacjaRapeseed straw is an attractive fuel material for microbial fuel cells (MFCs) due to its high content of carbohydrates (more than 60% carbohydrates). This study has demonstrated that reducing sugars can be efficiently extracted from raw rapeseed straw by combination of hydrothermal pretreatment and enzymatic hydrolysis followed by utilization as a fuel in two-chamber MFCs for electrical power generation. The most efficient method...
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Experimental review of the performances of protective coatings for interconnects in solid oxide fuel cells
PublikacjaFerritic stainless steel interconnects are used in solid oxide fuel cells; however, coatings are required to improve their performance. Although several types of coatings have been proposed, they have been scarcely investigated under similar conditions. This study compares the characteristics of uncoated Crofer 22 APU and eight different coatings on Crofer 22 APU for up to 3000 h at 800 ◦C. The coatings were deposited at various...
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Tribology of the cartilage cells in the intelligent bioreactor
PublikacjaW badaniach analityczno-numerycznych wyznaczone zostały pola prędkości przepływu lepkosprężystej, odżywczej nienewtonowskiej cieczy biologicznej, a także powstające siły tarcia w trakcie hodowli w warstwie granicznej wokoło powierzchni hodowanych komórek w bioreaktorach, stawach człowieka oraz w szczelinach mikrołożysk. Dodatkowo rozpatrywane będą przepływy potencjalne płynu stawowego z jamy stawowej, które odżywiają chrząstkę...