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Wyniki wyszukiwania dla: MTG
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Encapsulation of Amikacin into Microparticles Based on Low-Molecular-Weight Poly(lactic acid) and Poly(lactic acid-co-polyethylene glycol)
PublikacjaThe aim of this study was to fabricate novel microparticles (MPs) for efficient and long-term delivery of amikacin (AMI). The emulsification method proposed for encapsulating AMI employed low-molecular-weight poly(lactic acid) (PLA) and poly(lactic acid-co-polyethylene glycol) (PLA−PEG), both supplemented with poly(vinyl alcohol) (PVA). The diameters of the particles obtained were determined as less than 30 μm. Based on an in-vitro...
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Quality control of cheese samples for the presence of natamycin preservative – A natural deep eutectic solvent (NADES) based extraction coupled with HPLC
PublikacjaA new protocol for the determination of natamycin – an antifungal agent used as a food preservative - in cheese samples – is described. This new method is based on a natural deep eutectic solvent (NADES) green extraction procedure. High-performance liquid chromatography (HPLC) was used for detection and quantification. NADESs with different molar ratios were evaluated for efficient and selective extraction. NADES made of thymol...
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Bimetallic Bi/Cu0-catalyzed persulfate-based advanced oxidation processes towards clofibric acid degradation in wastewater
PublikacjaClofibric acid (CFA), an important blood-lipid regulatory drug is an emerging organic pollutant and widely reported in water resources. A novel bimetallic, bismuth/zero valent cupper (Bi/Cu0) catalyst was prepared which showed better physiological, structural, and catalytic properties than Cu0. The Bi/Cu0 effectively catalyzed persulfate (S2O82−) and caused 85% degradation of CFA. The Bi coupling improved reusability and stability...
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The dispersive micro-solid phase extraction method for MS-based lipidomics of human breast milk*
PublikacjaA simple and rapid microextraction method ensuring high lipidome coverage was developed for liquid chromatography mass spectrometry (LC-MS)-based lipidomics of human breast milk. The dispersive microsolid phase extraction (D-µ-SPE) technique, coupled with the design of experiment (DoE) method, enabled the study of the influence of several conditions (desorption solvent, stationary phase ratio, and sorption and desorption time)...
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Renewable Resources for Polyurethanes and Polyurethane Composites: A Review
PublikacjaEach year, more than two million tons of polyurethane is produced in the EU by reacting isocyanates with polyols made from fossil fuel. In addition, there are appreciable quantities of petroleum based functional additives applied in the industry nowadays for both polyols and polyurethane materials. It is therefore of key importance to develop sustainable economically viable polyols with enhanced functionalities, and thereby reducing...
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Validated HPTLC method for determination of ledol and alloaromadendrene in the essential oil fractions of Rhododendron tomentosum plants and in vitro cultures and bioautography for their activity screening
PublikacjaRhododendron tomentosum (Ledum palustre) is a bog shrub used in traditional medicine for treatment of respiratory and rheumatic diseases. Due to the large variability of the chemical composition of its essential oil, depending on the habitat, the in vitro cultures were established as the alternative source of the volatile fraction. There is a need to monitor a quality of the field grown as well as in vitro plant material, especially...
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Application of dynamic headspace and gas chromatography coupled to mass spectrometry (DHS-GC-MS) for the determination of oxygenated volatile organic compounds in refinery effluents
PublikacjaThe paper presents a new procedure for the determination of oxygenated volatile organic compounds (O-VOCs) in postoxidative effluents from the production of petroleum asphalt using dynamic headspace coupled to gas chromatography-mass spectrometry in the selected ion monitoring (SIM) mode (DHSGC-MS). Among the GC capillary columns tested, a polar SLB-IL111 column with the ionic liquid stationary phase was found to be superior due...
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ADAPTATION OF THE ACTIVATED SLUDGE TO THE DIGESTATE LIQUORS DURING THE NITRIFICATION AND DENITRIFICATION PROCESSES
PublikacjaThe activated sludge process of the digestate liquors after chemical separation was conducted using a 10 L lab-scale sequencing batch reactor (SBR) and a 0.50 m3 pilotscale SBR independently (with pH control). Due to the relatively high concentration of free ammonia (FA), clear inhibitory effects of the digestate liquors on the nitrifying bacteria were observed. The adaptation of the activated sludge to the toxicity was evaluated...
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Properties of New Composite Materials Based on Hydroxyapatite Ceramic and Cross-Linked Gelatin for Biomedical Applications
PublikacjaThe main aim of the research was to develop a new biocompatible and injectable composite with the potential for application as a bone-to-implant bonding material or as a bone substitute. A composite based on hydroxyapatite, gelatin, and two various types of commercially available transglutaminase (TgBDF/TgSNF), as a cross-linking agent, was proposed. To evaluate the impacts of composite content and processing parameters on various...
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Role of quantitative chest perfusion computed tomography in detecting diabetic pulmonary microangiopathy
PublikacjaAims: Aimof the study was to determine the role of perfusion chest computed tomography(pCT) in evaluation of pulmonary diabetic angiopathy.Methods: 18 never-smoking patients (10 diabetic patients and 8 healthy controls) underwentchest high resolution CT (HRCT) and then pCT scanning. In both groups, blood tests,biochemical analysis, fibrinogen, HbA1c, spirometry, diffusion capacity for carbonmonoxide(DLCO) and body pletysmography...
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Czynniki ludzkie a energetyka gazowa – wybrane zagadnienia
PublikacjaTechnologie wykorzystania gazu jako nośnika energii wzbudzają wiele zainteresowania. Powstają coraz to nowe inwestycje tj. blok gazowo – parowy Stalowa Wola czy też Gazoport w Świnoujściu. Poszukuje się alternatywy dla technologii węglowych poprzez podejmowane próby zgazowania węgla czy wydobycia i wykorzystania gazu z łupków. Dynamiczne otoczenie i potrzeba adaptacji rozwiązań funkcjonujących poza granicą kraju wymusza potrzebę...
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Zastosowania chromatografii wykluczania (SEC) w analityce technicznej i preparatyce – część I-sza.
PublikacjaW pracy scharakteryzowano założenia teoretyczne oraz mechanizm rozdzielania w warunkach chromatografii wykluczania (SEC). Przeanalizowano wady i zalety tej techniki rozdzielania. Przedstawiono przegląd zastosowań obejmujący wykorzystanie SEC w analityce technicznej oraz w preparatyce. SEC w warunkach liofilowych znajduje zastosowanie do rozdzielania mieszanin polimerów t.j. polistyren, polibutadien, poliizopren, poli(dimetylosiloksan),...
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Study of the Anti-Staphylococcal Potential of Honeys Produced in Northern Poland
PublikacjaThe antimicrobial activity of 144 samples of honeys including 95 products from apiaries located in Northern Poland was evaluated. The antibacterial activity of those natural products, their thermal stability, and activity in the presence of catalase was investigated by microdilution assays in titration plates. The MTT assay was performed for the determination of anti-biofilm activity. Spectrophotometric assays were used for the...
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Anticancer and antimicrobial properties of novel η6-p-cymene ruthenium(ii) complexes containing a N,S-type ligand, their structural and theoretical characterization
PublikacjaRuthenium(II) complexes are lately of great scientific interest due to their chemotherapeutic potential asanticancer and antimicrobial agents. Here we present the synthesis of new pyrazole carbothioamidederivatives and their four arene–ruthenium complexes. The title compounds were characterized with theapplication of IR, NMR, mass spectrometry, elemental analysis and X-ray diffraction. Additionally, for newcomplexes DFT calculations...
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Stopniowa chromatografia cienkowarstwowa w normalnych układach faz (NP-TLC), jako technika rozdzielania i oceny składu grupowego frakcji asfaltenowych z utleniania pozostałości próżniowej ropy naftowej
PublikacjaW pracy opisano wyniki badań nad opracowaniem metodyki oceny składu grupowego i czystości frakcji asfaltenowych techniką chromatografii cienkowarstwowej w normalnych układach faz (NP-TLC). Skupiono się na doborze takich parametrów/warunków rozdzielania, jak stężenie i masa próbki, a także skład i kolejność eluentów stosowanych podczas rozwijania chromatogramów TLC. Zastosowana trój-stopniowa metodyka polega na nałożeniu 5 µL frakcji...
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Wykorzystanie odpadów polistyrenowych do napełnenia elastomerów uretanowych otrzymanych z glikolizatów
PublikacjaZaprezentowano metodę otrzymywania kompozycji poliuretanowo-polistyrenowych z wykorzystaniem odpadów polistyrenowych z płyt do elewacji budynków i glikolizatów (pozyskanych w procesie glikolizy odpadów poliuretanowych) oraz wyniki pomiarów wybranych właciwoci uzyskanych materiałów. Zastosowanie 1,4-butanodiolu oraz odpadowego polistyrenu jako napełniacza podwyższało stabilnoć termicznš (TG) kompozycji w porównaniu z poliuretanem...
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Thermostable beta-glucosidase with a broad substrate specifity suitable for processing of lactose-containing products.
PublikacjaHipertermofilny archeon Sulfolobus shibatae wytwarza termostabilną beta glukozydazę przydatną do hydrolizy laktozy w mleku i serwatce przejawiającą największą aktywność w 85 stC przy pH 5,5. Aktywność ekstraktu bezkomórkowego Sulfolobus shibatae wynosi 0.29 U/mg białka i może być 17-krotnie zwiększona poprzez frakcjonowanie siarczanem amonu, chromatografię jonowymienną i filtrację żelową. Badany enzym ma dużą termostabilność i...
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Wykonanie badań nieniszczących krzyżownicy oraz śrub sprzęgła Hydrozespołu nr 4 w Elektrowni Wodnej we Włocławku
PublikacjaCelem badań było określenie stanu technicznego spoin krzyżownicy górnej łożyska prowadzącego generatora hydrozespołu nr 4 w Elektrowni wodnej we Włocławku. Badaniom nieniszczącym VT, UT i MT poddano spoiny czołowe i pachwinowe 12 ramion krzyżownicy, oraz dwa rodzaje śrub sprzęgła. Wykryte niezgodności spawalnicze opisano, podając przyczyny ich powstawania. Opracowano wytyczne technologiczne naprawy, ze szczególnym uwzględnieniem...
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The effect of transglutaminase on the properties of salmon skin-gelatin films
PublikacjaCelem pracy była enzymatyczna modyfikacja folii otrzymanych z żelatyny rybnej. Źródłem żelatyny były surowe i wędzone skóry łososia. Stwierdzono, że czas żelowania roztworu żelatyny ulegał skróceniu w obecności transglutaminazy w badanym zakresie 0,1-0,2 mg/ml. Enzymatyczne modyfikacje prowadziły do obniżenia rozpuszczalności folii, jednakże w różnym stopniu zależnym od źródła białka. Obecność DTT lub cysteiny w mieszaninie reakcyjnej...
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Liquefaction of macroalgae Enteromorpha biomass for the preparation of biopolyols by using crude glycerol
PublikacjaThis article describes the liquefaction process of macroalgae Enteromorpha with the use of crude glycerol as a solvent and a reagent, aimed at obtaining of new bio-polyols, which are characterized with respect to their chemical structure, physical and thermal properties. Six different biopolyols were prepared. In order to optimize the liquefaction of algal biomass for the best bio-polyol properties, two catalysts (sulfuric or orthophosphoric...
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Badania rozmieszczenia metali ciężkich w osadach dennych zbiorników retencyjnych na terenie zlewni zurbanizowanej
PublikacjaPotoki na terenach miejskich stanowią odbiornik dla kolektorów kanalizacji deszczowej oraz dla spływów powierzchniowych, które spłukują zanieczyszczenia z terenu zlewni. W zbiornikach retencyjnych budowanych na potokach m.in. w celu ochrony przed powodzią, następuje sedymentacja zawiesiny ogólnej, stanowiącej nośnik dla innych zanieczyszczeń, między innymi metali ciężkich. Źródłem metali ciężkich w zlewni miejskiej jest przede...
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In Vitro Dissolution of Na-Ca-P-Oxynitrides
Publikacja: Sodium-calcium-phosphate based oxynitride glasses and glass-ceramics doped with Mg, Si, and Nb were studied in vitro in simulated body fluid (SBF) under static conditions. The release of ions and pH changes up to 7 days of immersion were investigated. The nitrogen incorporation into phosphate glass matrix was found to notably influence in vitro dissolution only of homogenous glasses. Increasing the nitrogen content in the samples...
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Badania spektroskopowe wybranych silanotiolanów metali o budowie polimerycznej
PublikacjaPodjęto próby otrzymania tri-tert-butoksysilanotiolanowych kompleksów niklu(II), kobaltu(II), cynku(II) i kadmu(II) o budowie polimerycznej mogących pełnić rolę prekursorów w syntezie materiałów funkcjonalnych. W tym celu przeprowadzono syntezy odpowiednich silanotiolanowych metali z grupą diamin alifatycznych. Otrzymano szereg nowych obojętnych polimerów koordynacyjnych o budowie przestrzennej typu 1D. Dla siedmiu z nich zostały...
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Application of INAA and ETAAS techniques for human samples analysis in evaluation of the impact of Gdansk Phosphatic Fertilizer Plant on its workers
PublikacjaW pracy przedstawiono wyniki badań wpływu Gdańskich Zakładów Nawozów Fosforowych na zdrowie pracowników. Oznaczano stężenia (techniką INAA) Al, As,Au, Br, Ca, Cl, Cu, Dy, I, In, K, La, Mg, Mn, Mo, Na, S, Sb, Sm, Ti, U, V,W, Zn we włosach, paznokciach i filtrach z pyłem zebranych od 21 pracowników fabryki oraz 5 osób z grupy kontrolnej nie związanej z zakładem. Ponadto oznaczono Cd, Cr, Cu, Fe, Mo, Ni i Zn w moczu przy użyciu...
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The comparison of cytotoxic and genotoxic activities of glucosinolates, isothiocyanates, and indoles
PublikacjaChemopreventive properties of Brassica vegetables are attributed mainly to their characteristic compounds—glucosinolates (GLs) and their main hydrolysis products—isothiocyanates (ITCs) and indoles. In this study, we compared antiproliferative activity (MTT test in HT29 cells) and genotoxic effects (comet assay in HT29 cells and restriction analysis in a cell-free system) of three GLs (sinigrin (SIN), glucotropaeolin (GTL), and...
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Bioactive hybrid metal-organic framework (MOF)-based nanosensors for optical detection of recombinant SARS-CoV-2 spike antigen
PublikacjaFast, efficient, and accurate detection of SARS-CoV-2 spike antigen is pivotal to control the spread and reduce themortality of COVID-19. Nevertheless, the sensitivity of available nanobiosensors to detect recombinant SARS-CoV-2 spike antigen seems insufficient. As a proof-of-concept, MOF-5/CoNi2S4 is developed as a low-cost, safe, and bioactive hybrid nanostructure via the one-pot high-gravity protocol. Then, the porphyrin, H2TMP,...
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Juices from non-typical edible fruits as health-promoting acidity regulators for food industry
PublikacjaThe study verifies the possibility of application of juices from selected fruits characterized by the high antioxidant potential as natural acidity regulators with improved nutritional properties. The tested non-typical fruits included mirabelle plum, sea buckthorn and blue-berried honeysuckle. Beetroot juice whose pH is about 6.0 served as a model food product. Potentiometric titration was used to compare the efficacy of tested...
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Thermosensitive composite based on agarose and chitosan saturated with carbon dioxide. Preliminary study of requirements for production of new CSAG bioink.
PublikacjaThis study introduces a method for producing printable, thermosensitive bioink formulated from agarose (AG) and carbon dioxide-saturated chitosan (CS) hydrogels. The research identified medium molecular weight chitosan as optimal for bioink production, with a preferred chitosan hydrogel content of 40–60 %. Rheological analysis reveals the bioink's pseudoplastic behavior and a sol-gel phase transition between 27.0 and 31.5 °C. The...
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Millimeter Wave Negative Refractive Index Metamaterial Antenna Array
PublikacjaIn this paper, a novel negative refractive index metamaterial (NIM) is developed and characterized. The proposed metamaterial exhibits negative effective permittivity (εeffe) and negative effective permeability (µeffe) at millimeter wave frequency of 28GHz. This attractive feature is utilized to enhance the gain of a microstrip patch antenna (MPA). Two thin layers of 5 5 subwavelength unit cell array of NIM are placed above a...
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INVESTIGATIONS OF THE EMISSION CHARACTERISTICS OF A DUAL-FUEL GAS TURBINE COMBUSTION CHAMBER OPERATING SIMULTANEOUSLY ON LIQUID AND GASEOUS FUELS
PublikacjaT his study is dedicated to investigations of the working process in a dual-fuel low-emission combustion chamber for a floating vessel’s gas turbine. As the object of the research, a low-emission gas turbine combustion chamber with partial premixing of fuel and air inside the outer and inner radial-axial swirls was chosen. The method of the research is based on the numerical solution of the system of differential...
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Kinetics of the Organic Compounds and Ammonium Nitrogen Electrochemical Oxidation in Landfill Leachates at Boron-Doped Diamond Anodes
PublikacjaElectrochemical oxidation (EO) of organic compounds and ammonium in the complex matrix of landfill leachates (LLs) was investigated using three different boron-doped diamond electrodes produced on silicon substrate (BDD/Si)(levels of boron doping [B]/[C] = 500, 10,000, and 15,000 ppm—0.5 k; 10 k, and 15 k, respectively) during 8-h tests. The LLs were collected from an old landfill in the Pomerania region (Northern Poland) and were...
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Fotometryczny czujnik glukozy oparty na enzymatycznych paskach testowych
PublikacjaCukrzyca jest chorobą dotykającą co roku na całym świecie około 3 mln ludzi [1]. Brak możliwości wyleczenia choroby generuje koszty związane z jej monitorowaniem. W USA corocznie wydaje się na ten cel 174 mld dolarów [2]. Stężenie glukozy we krwi zdrowego człowieka na czczo waha się od 80 mg/dl do 110 mg/dl [3]. Stan organizmu z niedoborem glukozy nazywany jest hipoglikemią, a stan podwyższonej zawartości cukru – hiperglikemią...
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Seismic damage diagnosis in adjacent steel and RC MRFs considering pounding effects through improved wavelet-based damage-sensitive feature
PublikacjaThis paper aims to propose complex Morlet (cmorfb-fc) wavelet-based refined damage-sensitive feature (rDSF) as a new and more precise damage indicator to diagnose seismic damages in adjacent steel and Reinforced Concrete (RC) Moment Resisting Frames (MRFs) assuming pounding conditions using acceleration responses. The considered structures include 6- and 9-story steel and 4- and 8-story RC benchmark...
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Environmental characteristics of a tundra river system in Svalbard. Part 2: Chemical stress factors
PublikacjaBacterial communities in the Arctic environment are subject to multiple stress factors, including contaminants, although typically their concentrations are small. The Arctic contamination research has focused on persistent organic pollutants (POPs) because they are bioaccumulative, resistant to degradation and toxic for all organisms. Pollutants have entered the Arctic predominantly by atmospheric and oceanic long-range transport,...
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Recombinant !ermostable AP Exonuclease from Thermoanaerobacter tengcongensis: Cloning, Expression, Purification, Properties and PCR Application
PublikacjaApurinic/apyrimidinic (AP) sites in DNA are considered to be highly mutagenic and must be corrected to preserve genetic integrity, especially at high temperatures. !e gene encoding a homologue of AP exonuclease was cloned from the thermophilic anaerobic bacterium Thermoanaerobacter tengcongensis and transformed into Escherichia coli. The protein product showed high identity (80%) to human Ape1 nuclease, whereas to E. coli exonuclease...
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Fluorescence studies by quenching and protein unfolding on the interaction of bioactive compounds in water extracts of kiwi fruit cultivars with human serum albumin
PublikacjaThe main aim of this investigation was to characterize new kiwi fruit cultivars after cold storage treatment and to determine the similarities and differences between them, using spectroscopic methods. The chemometric comparison of kiwi fruit cultivars based on physicochemical indices during cold storage was carried out. All kiwi fruit cultivars showed a high level of correlation between the contents of phenolic compounds (polyphenols,...
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Enzymatic cross-linking of β-lactoglobulin in solution and at air–water interface: Structural constraints
PublikacjaEffective and controlled use of cross-linking enzymes in structure engineering of food systems depends on characterization of the favorable conditions for enzyme-substrate complex and the limiting factors for the desired modification. In this respect, we analyzed the susceptibility of bovine β-lactoglobulin (BLG) to enzymatic cross-linking by Trichoderma reesei tyrosinase (TrTyr) and transglutaminase (TG). Changes in BLG molecular...
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Phosphorus removal by application of natural and semi-natural materials for possible recovery according to assumptions of circular economy and closed circuit of P
PublikacjaIn the last fewyears the idea of circular economy has become essential. Thus, designing methods of nutrients removal should be based on usingmaterials that make it possible to recover those nutrients. Recently,methods applied in wastewater treatment plants cannot provide optimal results; moreover, the application of commercial coagulants like ferric chloride and polyaluminumchloride can cause difficulties in potential recovery...
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A XAS study of a highly diluted Pt electrocatalyst operating in PEM fuel cells
PublikacjaWe present an X-ray absorption spectroscopy (XAS) study of a low Pt content catalyst layer(Pt loading 0.1 mg c2) operating at the cathode of a proton exchange membrane fuel cell(PEMFC). This catalyst is based on the use of a mesoporous inorganic matrix as a support forthe catalyst Pt nanoparticles. Due to the high Pt dilution, in situ measurements of itsstructural properties by XAS are challenging and suitable experimental strategies...
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Granulometric analysis to etimate influence of anionic surfactrant on activated sludge structure
PublikacjaThe work concerns the evaluation of the possibility of using laser diffraction analyzer to determine changes in the distribution of sludge floc size in the presence of anionic surfactant. As a model of surfactant linear alkylbenzyne sulphonate (LAS) was used. The granulometric analysis showed that the pure activated sludge was composed of particles with a size of 0,001 to 2 mm. The largest and fastest changes in the distribution...
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Self-assemblies of novel magnesium porphyrins mimicking natural chlorosomal bacteriochlorophylls
PublikacjaSelf-assembling porphyrins are promising materials to mimic natural bacteriochlorophylls c, d, or e encountered in the chlorosomes of photosynthetic bacteria. We have studied four novel magnesium porphyrins mimicking this chlorosomal antenna system. In contrast to previous articles reporting synthetic Zn-porphyrins, our studies focus on porphyrins with Mg as the central atom, which mimic more closely the natural bacteriochlorophylls....
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Review and Indication of Key Activities for Energy Management Improvement in DC Microgrids
PublikacjaDC MicroGrids (MG) must have Energy Management Systems (EMS) to guarantee efficient, dependable, and environmentally friendly electricity. The application of Model Predictive Control (MPC), proved to be helpful due to its adaptability and capacity to use non-linear models. This paper, based on an extensive literature review, identifies and discusses the three key activities to improve the characteristics of DC microgrids, i.e.:...
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High-performance method of carbon nanotubes modification by microwave plasma for thin composite films preparation
PublikacjaIn this work we present a simple and efficient method of nitrogen plasma modification of carbon nanotubes (CNTs). The process allows for treatment of the nanotubes in the form of powder with quite a high yield (65 mg of CNTs per hour). The modified carbon nanotubes contain approx. 3.8% of nitrogen, mostly in the pyridinic form. Plasma treated CNTs exhibit better dispersibility in water and higher electric capacitance than pristine...
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Inverse Modeling and Optimization of CSRR-based Microwave Sensors for Industrial Applications
PublikacjaDesign optimization of multivariable resonators is a challenging topic in the area of microwave sensors for industrial applications. This paper proposes a novel methodology for rapid re-design and parameter tuning of complementary split-ring resonators (CSRRs). Our approach involves inverse surrogate models established using pre-optimized resonator data as well as analytical correction techniques to enable rapid adjustment of geometry...
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Combined effect of nitrogen-doped functional groups and porosity of porous carbons on electrochemical performance of supercapacitors
PublikacjaIn this work, nitrogen-doped porous carbons obtained from chitosan, gelatine, and green algae were investigated in their role as supercapacitor electrodes. The effects of three factors on electrochemical performance have been studied— of the specific surface area, functional groups, and a porous structure. Varying nitrogen contents (from 5.46 to 10.08 wt.%) and specific surface areas (from 532 to 1095 m2g−1) were obtained by modifying...
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Relationship between conversion rate of glucosinolates to isothiocyanates/indoles and genotoxicity of individual parts of Brassica vegetables
PublikacjaThe studies on the characterisation of glucosinolates (GLs) and their breakdown products in Brassicaceae species focus mainly on the edible parts. However, other products, e.g., dietary supplements, may be produced also from non-edible parts such as roots or early forms of growth: seeds or sprouts. Biological activity of these products depends on quantitative and qualitative GL composition, but is also strictly determined by GL...
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Novel molecules containing structural features of NSAIDs and 1,2,3-triazole ring: Design, synthesis and evaluation as potential cytotoxic agents
PublikacjaFor the first time the template containing structural features of more than one NSAIDs and the 1,2,3-triazole ring was explored for the identification of potential cytotoxic agents. These new and complex molecules were predicted to be effective inhibitors of PDE4B by molecular modelling studies in silico. The multi-step synthesis of these compounds were carried out starting from the well-known drug nimesulide and involved the use...
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Red Kale (Brassica oleracea L. ssp. acephala L. var. sabellica) Induces Apoptosis in Human Colorectal Cancer Cells In Vitro
PublikacjaThis article presents the results of studies investigating the effect of red kale (Brassica oleracea L. ssp. acephala L. var. sabellica) extract on cancer cells (HT-29). The cytotoxicity of the red kale extract was assessed using MTT and LDH assays, while qRT-PCR was employed to analyze the expression of genes associated with the p53 signaling pathway to elucidate the effect of the extract on cancer cells. Furthermore, HPLC-ESI-QTOF-MS/MS...
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Relationship between Chemical Structure and Biological Activity Evaluated In Vitro for Six Anthocyanidins Most Commonly Occurring in Edible Plants
PublikacjaNumerous studies have provided evidence that diets rich in anthocyanins show a broad spectrum of health benefits. Anthocyanins in nature are usually found in the form of glycosides. Their aglycone forms are called anthocyanidins. The chemical structure of anthocyanins is based on the flavylium cation, but they differ in the position and number of substituents. However, the bioactives and foods that contain them are frequently treated...
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In vitro enzyme kinetics and NMR-based product elucidation for glutathione S-conjugation of the anticancer unsymmetrical bisacridine C-2028 in liver microsomes and cytosol: major role of glutathione S-transferase M1-1 isoenzyme
PublikacjaThis work is the next step in studying the interplay between C-2028 (anticancer-active unsymmetrical bisacridine developed in our group) and the glutathione S-transferase/glutathione (GST/GSH) system. Here, we analyzed the concentration- and pH-dependent GSH conjugation of C-2028 in rat liver microsomes and cytosol. We also applied three recombinant human GST isoenzymes, which altered expression was found in various tumors. The...