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A strong preference for the TA/TA dinucleotide step discovered for an acridine-based, potent antitumor dsDNA intercalator, C-1305: NMR-driven structural and sequence-specificity studies
PublicationTriazoloacridinone C-1305, a potent antitumor agent recommended for Phase I clinical trials, exhibits high activity towards a wide range of experimental colon carcinomas, in many cases associated with complete tumor regression. C-1305 is a well-established dsDNA intercalator, yet no information on its mode of binding into DNA is available to date. Herein, we present the NMR-driven and MD-refined reconstruction of the 3D structures...
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Analysis of Modal Parameters Using a Statistical Approach for Condition Monitoring of the Wind Turbine Blade
PublicationThe primary objective of the presented paper is the numerical and experimental investigation related to developing a useful diagnostic method, which can be used for determining the site and size of damage in laminated shells of wind turbine blades. The described detection technique is based on the analysis of low frequencies bending vibrations mode shapes of rotor blades. The authors used the commonly applied statistics methods...
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Degradation of electrical performance of a crystalline photovoltaic module due to dust deposition in northern Poland
PublicationThe reduction in power output caused by the accumulation of dust on the photovoltaic module surface is an important problem and should receive much more attention in the literature. This study was an evaluation of the performance degradation of crystalline photovoltaic modules due to natural and simulated dust deposition. Dust is created from powdered grains of sand and particles of different bodies. Dust originates from different...
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Application of human bile salts for in vitro digestion models
PublicationIn this study, experimental in vitro models simulating the environment of the human gastrointestinal tract were used to assess the impact of physiological surfactants, such as bile salts, on the kinetics of digestion. Bile salts are biosurfactants synthesised in the liver and secreted together with bile into the small intestine. There are many reports on the role of bile salts in lipolysis, but the knowledge of their influence...
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A methodology for ultimate strength assessment of ship hull girder accounting for enhanced corrosion degradation modelling
PublicationThe presented work shows a methodology for the ultimate strength assessment of a ship hull, considering enhanced corrosion modelling. The approach is based on the classical Smith method. However, the recent findings regarding the impact of corrosion degradation on ultimate strength are incorporated. To this end, the stress–strain relationships for particular elements composing ship hull cross-section are modified using a specially...
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Maritime traffic situation awareness analysis via high-fidelity ship imaging trajectory
PublicationSituation awareness provides crucial yet instant information to maritime traffic participants, and significant attentions are paid to implement traffic situation awareness task via various maritime data source (e.g., automatic identification system, maritime surveillance video, radar, etc.). The study aims to analyze traffic situation with the support of ship imaging trajectory. First, we employ the dark channel prior model to...
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The effect of macro polymer fibres length and content on the fibre reinforced concrete
PublicationThe paper presents studies of a ready-mix concrete containing polymer fibres of three different lengths: 24, 38 and 54 mm. The performed tests allowed to determine the effect of fibre volume fraction and length on the concrete strength. The basic parameters of concrete mixture (consistency, air content and bulk density) were identified. Fibre reinforced concrete belongs to a group of composite materials. The polymer fibres are...
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Multi-transformer primary-side regulated flyback converter for supplying isolated IGBT and MOSFET drivers
PublicationThis paper presents primary-side voltage regulated multi-transformer quasi-resonant flyback converter (MTFC) for supplying isolated power switch drivers. The proposed topology offers distinct advantages over frequently used flyback converter possessing one high frequency transformer with isolated multiple outputs. Particularly, when a large number of separate dc supply units is required, then MTFC enables improved regular distribution...
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Wave Frequency Effects on Damage Imaging in Adhesive Joints Using Lamb Waves and RMS
PublicationStructural adhesive joints have numerous applications in many fields of industry. The gradual deterioration of adhesive material over time causes a possibility of unexpected failure and the need for non-destructive testing of existing joints. The Lamb wave propagation method is one of the most promising techniques for the damage identification of such connections. The aim of this study was experimental and numerical research on...
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Age Prediction from Low Resolution, Dual-Energy X-ray Images Using Convolutional Neural Networks
PublicationAge prediction from X-rays is an interesting research topic important for clinical applications such as biological maturity assessment. It is also useful in many other practical applications, including sports or forensic investigations for age verification purposes. Research on these issues is usually carried out using high-resolution X-ray scans of parts of the body, such as images of the hands or images of the chest. In this...
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Eksperymentalna weryfikacja procedury szacowania wytrzymałości młodego betonu wg normy ASTM C1074
PublicationW referacie przedstawiono metodę służącą oszacowaniu wytrzymałości betonu w trakcie procesu dojrzewania (ang. Maturity Method) bazującą na procedurze określonej zgodnie z amerykańską normą, która uwzględnia wpływ połączonych efektów temperatury i czasu na rozwój wytrzymałości betonu. Standardy ASTM C1074 zostały opracowane przez NBS (ang. National Bureau of Standards) z uwagi na powtarzające się wypadki na palcu budowy wynikające...
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Spawalność ferrytyczno-austenitycznej stali odpornej na korozję typu dupleks 2205 w warunkach podwodnych
PublicationPraca dotyczy problemów spawalności stali odpornej na korozję typu dupleks w warunkach spawania mokrego elektrodami otulonymi i lokalną komorą suchą. Całość rozprawy składa się z dwóch części. Część pierwsza to przegląd literatury, w którym omówiono główne problemy wynikające z przeniesienia procesu spawania pod wodę oraz sposoby minimalizowania negatywnego wpływu środowiska. Część druga jest częścią doświadczalną, zawiera tezę...
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Active Annotation in Evaluating the Credibility of Web-Based Medical Information: Guidelines for Creating Training Data Sets for Machine Learning
PublicationMethods Results Discussion References Abbreviations Copyright Abstract Background: The spread of false medical information on the web is rapidly accelerating. Establishing the credibility of web-based medical information has become a pressing necessity. Machine learning offers a solution that, when properly deployed, can be an effective tool in fighting medical misinformation on the web. Objective: The aim of this study is to...
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Multi-response optimization on the effect of wet and eco-friendly cryogenic turning of D2 steel using Taguchi-based grey relational analysis
PublicationMaterial removal processes, including turning and milling, are still commonly used operations for manufacturing most of mechanical components in modern industry. Apart from the cutting parameters, the cooling method has the great impact on the technological efects and, above all, on the environmental friendliness of production. In this study, multi-response optimization on the efect of wet and cryogenic machining is performed during...
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Numerical analysis of lumbar spine injury during road safety barrier collision
PublicationPurpose: Enhancing road safety is a critical goal worldwide, necessitating the development of clear standards for road safety systems. This study focuses on lumbar spine (L-spine) compression injuries during collisions with concrete road safety barriers (RSBs). It aims to analyze internal forces during impact to understand L-spine injury biomechanics in such accidents. Methods: The research included a literature review, analyzing...
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Natural convection in symmetrically heated vertical channels
PublicationThe study describes natural convection through a vertical channel, open on four sides and bound by two isothermal walls. Both balancing and infrared experimental investigations were performed in air (Pr = 0.71) to estimate the impact of channel width s and wall-to-ambient temperature difference (tw - t∞) on natural convective heat transfer, the formation of air flow patterns and the rate of flow pattern formation. The study was...
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Nutrient transport and acquisition by diatom chains in a moving fluid
PublicationThe role of fluid motion in delivery of nutrients to phytoplankton cells is a fundamental question in biological and chemical oceanography. In the study of mass transfer to phytoplankton, diatoms are of particular interest. They are non-motile, are often the most abundant components in aggregates and often form chains, so they are the ones expected to benefit most from enhancement of nutrient flux due to dissipating turbulence....
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Numerical investigation on distribution characteristics of oxidation air in a lime slurry desulfurization system with rotary jet agitators
PublicationRotary jet agitator is an effective device for mixing, dispersing, dissolving, and suspending dispersed phases in liquid, and is particularly advantageous to the homogenization of oxygen-enriched air within the lime slurry desulfurization system. The distribution of oxygen-enriched air in agitators is vital for the process of gypsum crystallization and the homogeneous and sufficient oxygen-enriched air can promote the formation...
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Load capacity of steel-aluminium brackets under static and cyclic laboratory tests
PublicationThe aim of the research is the laboratory investigation of steel-aluminium brackets employed to fasten lightweight curtain walls to building facilities. Static pressure, suction forces, and cyclic loads parallel to end plates (horizontal – to simulate wind influence) were applied in the study. The steel-aluminium brackets were tested on a reinforced concrete substrate made of C30/37 concrete class to simulate the real working conditions....
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The influence oil additives on spread cracks in silicon nitride
PublicationThe paper presents an experimental study of the influence of oil additives (Cl, S, P, cerium dioxide (CeO2)) on spread cracks in silicon nitride. The additives Cl, S, P are bound in molecules in liquid form soluble in the base oil. The CeO2 is purely in powder form in suspension. The use of CeO2 powder was made based on the good results of polishing of silicon nitride. A ceramic angular contact ball bearing was modelled using a...
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Earthquake-induced pounding between asymmetric steel buildings
PublicationEarthquake-induced pounding between buildings has been the subject of numerous numerical and experimental studies in the resent years. The phe-nomenon may cause severe damage to structural elements as well as may also lead to the total collapse of colliding structures. A major reason leading to pounding between adjacent, insufficiently separated buildings results from the differences in their dynamic properties. The aim of this...
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Electrochemical, theoretical and surface physicochemical studies of the alkaline copper corrosion inhibition by newly synthesized molecular complexes of benzenediamine and tetraamine with π acceptor
PublicationTwo charge transfer complexes, namely [(BDAH)+(PA−)] CT1 [(BTAH)2+(PA−)2] and CT2 (BDAH = 1,2-benzenediamine, BTAH = 1,2,4,5-benzenetetramine, and PA− = 2,4,6-trinitrophenolate), were synthesized and fully characterized using various spectroscopic techniques. CT1 and CT2 were tested as inhibitors to effectively control the uniform and anodic corrosion processes of copper in an alkaline electrolyte (1.0 M KOH) using various electrochemical...
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An analysis of wind conditions at pedestrian level in the selected types of multi-family housing developments
PublicationThe following article addresses the issue of wind conditions around urban building development at pedestrian level. Factors that depend on those issues include wind comfort and air quality within urbanized spaces. The conditions specific of cities located in a temperate climate zone have been taken into account. The article is intended to identify aerodynamic phenomena characteristic of the three basic types of multi-family building...
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Influence of Storage Time and Temperature on the Toxicity, Endocrine Potential, and Migration of Epoxy Resin Precursors in Extracts of Food Packaging Materials
PublicationThe aim of the present study was to establish a standard methodology for the extraction of epoxy resin precursors from several types of food packages (cans, multi-layered composite material, and cups) with selected simulation media (distilled water, 5% ethanol, 3% dimethyl sulfoxide, 5% acetic acid, artificial saliva) at different extraction times and temperatures (factors). Biological analyses were conducted to determine the acute...
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Effect of bending-torsion on fracture and fatigue life for 18Ni300 steel specimens produced by SLM
PublicationIn this study, different fracture surfaces caused by fatigue failure were generated from 18Ni300 steel produced by selective laser melting (SLM). Hollow round bars with a transverse hole were tested under bending-torsion to investigate the crack initiation mechanisms and fatigue life. Next, the post-failure fracture surfaces were examined by optical profilometer and scanning electron microscope. The focus is placed on the relationship...
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The importance of anchoring ligands of binuclear sensitizers on electron transfer processes and photovoltaic action in dye-sensitized solar cells
PublicationThe relatively low photon-to-current conversion efficiency of dye-sensitized solar cells is their major drawback limiting widespread application. Light harvesting, followed by a series of electron transfer processes, is the critical step in photocurrent generation. An in-depth understanding and fine optimization of those processes are crucial to enhance cell performance. In this work, we synthesize two new bi-ruthenium sensitizers...
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Optimizing Medical Personnel Speech Recognition Models Using Speech Synthesis and Reinforcement Learning
PublicationText-to-Speech synthesis (TTS) can be used to generate training data for building Automatic Speech Recognition models (ASR). Access to medical speech data is because it is sensitive data that is difficult to obtain for privacy reasons; TTS can help expand the data set. Speech can be synthesized by mimicking different accents, dialects, and speaking styles that may occur in a medical language. Reinforcement Learning (RL), in the...
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Domain segmentation for low-cost surrogate-assisted multi-objective design optimisation of antennas
PublicationAbstract: Information regarding the best possible design trade-offs of an antenna structure can be obtained through multiobjective optimisation (MO). Unfortunately, MO is extremely challenging if full-wave electromagnetic (EM) simulation models are used for performance evaluation. Yet, for the majority of contemporary antennas, EM analysis is the only tool that ensures reliability. This study introduces a procedure for accelerated...
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Impact of enhanced pretreatment on biological nutrient removal in municipal wastewater treatment plants
PublicationThe aim of this study was to determine the effect of enhanced primary treatment on: increasing primary sludge production for increased biogas production; reducing the organic load on downstream biological treatment processes and thereby reducing energy consumption for aeration; denitrification and enhanced biological phosphorus removal (EBPR) rates in the activated sludge system. For this purpose, three commercial organic polymers...
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ANALIZA AERODYNAMICZNA ŁOPAT NA PRZYKŁADZIE PROJEKTU DWUWIRNIKOWEJ TURBINY WIATROWEJ MAŁEJ MOCY
PublicationW artykule przedstawiono proces projektowania oraz analizy aerodynamicznej łopat turbiny wiatrowej z wykorzystaniem metody BEMT (ang. Blade Element Momentum Theory). Dokonano doboru profili aerodynamicznych oraz opisano procedurę wyznaczania optymalnego rozkładu kątów zwichrowania i długości cięciw profili w funkcji długości łopaty dla założonych parametrów wejściowych. Dokonano obliczenia działających sił oraz generowanej mocy...
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Effects of FSW Tool Plunge Depth on Properties of an Al-Mg-Si Alloy T-Joint: Thermomechanical Modeling and Experimental Evaluation
PublicationOne of the main challenging issues in friction stir welding (FSW) of stiffened structures is maximizing skin and flange mixing. Among the various parameters in FSW that can affect the quality of mixing between skin and flange is tool plunge depth (TPD). In this research, the effects of TPD during FSW of an Al-Mg-Si alloy T-joint are investigated. The computational fluid dynamics (CFD) method can help understand TPD effects on FSW...
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Exploration of the Solubility Hyperspace of Selected Active Pharmaceutical Ingredients in Choline- and Betaine-Based Deep Eutectic Solvents: Machine Learning Modeling and Experimental Validation
PublicationDeep eutectic solvents (DESs) are popular green media used for various industrial, pharmaceutical, and biomedical applications. However, the possible compositions of eutectic systems are so numerous that it is impossible to study all of them experimentally. To remedy this limitation, the solubility landscape of selected active pharmaceutical ingredients (APIs) in choline chloride- and betaine-based deep eutectic solvents was...
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Fracture Surface Behavior of 34CrNiMo6 High-Strength Steel Bars with Blind Holes under Bending-Torsion Fatigue
PublicationThe present study evaluates the fracture surface response of fatigued 34CrNiMo6 steel bars with transverse blind holes subjected to bending with torsion loading. The analysis of the geometric product specification was performed by means of height parameters Sx, functional volume parameters Vx, and fractal dimension Df. Surface topography measurements were carried out using an optical profilometer with focus variation technology....
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Detecting Lombard Speech Using Deep Learning Approach
PublicationRobust Lombard speech-in-noise detecting is challenging. This study proposes a strategy to detect Lombard speech using a machine learning approach for applications such as public address systems that work in near real time. The paper starts with the background concerning the Lombard effect. Then, assumptions of the work performed for Lombard speech detection are outlined. The framework proposed combines convolutional neural networks...
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A random field-based simulational identification of possible levels of material imperfections of adhesive-bonded joints
PublicationRecently, structural adhesives have become significant in the shaping of structural elements, especially in thin-walled structures, where they replace or supplement traditional connection methods. However, adhesive-bonded joints are highly susceptible to internal structural imperfections due to their application technique and the nature of the adhesive. These material inconsistencies impact the strength parameters and the mechanical...
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Effects of thermal history on the performance of low-temperature solid oxide fuel cells with Sm0.2Ce0.8O2-δ electrolyte and LiNi0.81Co0.15Al0.04O2 electrodes
PublicationIn this study, low-temperature solid oxide fuel cells with an ∼560 μm thick Sm0.2Ce0.8O2−δ (SDC) electrolyte and ∼890 μm thick LiNi0.81Co0.15Al0.04O2−δ (NCAL) electrodes are constructed and characterized under three experimental conditions. The cell with an NCAL cathode pre-reduced under an H2 atmosphere at 550 °C presents the best electrochemical performance. This is ascribed to facts that the reduction reaction generating Ni–Co...
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Optimal conditions of naphthoquinones separation from carnivorous plants extracts using thin-layer chromatography and high performance liquid chromatography
PublicationDroseraceae plants are owned by the family of carnivorous plants, which in an unusual way adapt to environments poor in nutrients. Droseraceae obtain essential nutrients catching insects and other small invertebrantes. Plumbagin, chloroplumbagin, ramentaceon and droseron are naphthoquinones, which could be found in leaves and shoots of plants from Droseraceae family. In the literature there are a lot of information about the pharmacological...
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Combining Computational Fluid Dynamics with a Biokinetic Model for Predicting Ammonia and Phosphate Behavior in Aeration Tanks
PublicationThe aim of this study was to use computational fluid dynamics for predicting the behavior of reactive pollutants (ammonia and phosphate) in the aerobic zone of the bioreactor located at the Wschod wastewater treatment plant in Gdansk, Poland. The one-dimensional advection-dispersion equation was combined with simple biokinetic models incorporating the Monod-type expressions as source terms for the two pollutants. The problem was...
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The influence of reactions conditions on aggregation of dyes used in biochemistry
PublicationSelf-association of dyes and related substances is a very important phenomenon in many fields of applied chemistry. It is also fundamental model reaction of many kinds of molecular interactions such as the micelle formation of amphiphilic substances and the binding of small organic molecules to macromolecules. In spite of many studies concerning the dimerization equilibria of dyes and related substances, the mechanism seems not...
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Fuzzy Control of Waves Generation in a Towing Tank
PublicationThis paper presents the results of research related to the transformation of electrical energy into potential and kinetic energy of waves generated on the water surface. The waves are generated to model the environmental conditions for the needs of the model tests. The model tests are performed on model-scale objects to predict the features of full-scale maritime objects. It is done to improve human safety and the survivability...
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Why do G-quadruplexes dimerize through the 5’-ends? Driving forces for G4 DNA dimerization examined in atomic detail
PublicationG-quadruplexes (G4) are secondary structures formed by guanine-rich nucleic acid sequences and shown to exist in living cells where they participate in regulation of gene expression and chromosome maintenance. G-quadruplexes with solvent-exposed guanine tetrads show the tendency to associate together through cofacial stacking, which may be important for packaging of G4-forming sequences and allows for the design of higher-order...
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The Role of Electron Transfer in the Fragmentation of Phenyl and Cyclohexyl Boronic Acids
PublicationIn this study, novel measurements of negative ion formation in neutral potassium-neutral boronic acid collisions are reported in electron transfer experiments. The fragmentation pattern of phenylboronic acid is comprehensively investigated for a wide range of collision energies, i.e., from 10 to 1000 eV in the laboratory frame, allowing some of the most relevant dissociation channels to be probed. These studies were performed in...
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Mechanism-based inactivation of human cytochrome P450 1A2 and 3A4 isoenzymes by antitumor triazoloacridinone C-1305.
Publication5-Dimethylaminopropylamino-8-hydroxytriazoloacridinone, C-1305, is a promising antitumor therapeutic agent with high activity against several experimental tumors. It was determined to be a potent and selective inhibitor of liver microsomal and human recombinant cytochrome P450 (CYP) 1A2 and 3A4 isoenzymes. Therefore, C-1305 might modulate the effectiveness of other drugs used in multidrug therapy. The objective of this study was...
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The Positioning Accuracy of BAUV Using Fusion of Data from USBL System and Movement Parameters Measurements
PublicationThe article presents a study of the accuracy of estimating the position coordinates of BAUV (Biomimetic Autonomous Underwater Vehicle) by the extended Kalman filter (EKF) method. The fusion of movement parameters measurements and position coordinates fixes was applied. The movement parameters measurements are carried out by on-board navigation devices, while the position coordinates fixes are done by the USBL (Ultra Short Base...
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Modeling nitrous oxide production by a denitrifying-enhancedbiologically phosphorus removing (EBPR) activated sludge in thepresence of different carbon sources and electron acceptors
PublicationIn this study, the IWA Activated Sludge Model No. 2d (ASM2d) was expanded to identify the most important mechanisms leading to the anoxic nitrous oxide (N2O) production in the combined nitrogen (N) and phosphorus (P) removal activated sludge systems. The new model adopted a three-stage denitrification concept and was evaluated against the measured data from one/two-phase batch experiments carried out with activated sludge withdrawn...
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Modeling lignin extraction with ionic liquids using machine learning approach
PublicationLignin, next to cellulose, is the second most common natural biopolymer on Earth, containing a third of the organic carbon in the biosphere. For many years, lignin was perceived as waste when obtaining cellulose and hemicellulose and used as a biofuel for the production of bioenergy. However, recently, lignin has been considered a renewable raw material for the production of chemicals and materials to replace petrochemical resources....
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Performance tuning of chitosan-based membranes by protonated 2-Pyrrolidone-5-carboxylic acid-sulfolane DES for effective water/ethanol separation by pervaporation
PublicationToday, the applicability of deep eutectic solvents (DES) in various fields, including membrane science and technology, is extensively investigated. In pioneering works, we have implemented different DES as a component of chitosan (CS)-based flat membranes for pervaporation (PV) separation. Herein, we present a new protonated (by sulphuric acid) 2-Pyrrolidone-5-carboxylic acid: sulfolane DES, as a green additive for its chemical...
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Multi-functional monodispersed SiO2-TiO2 core-shell nanostructure and TEOS in the consolidation of archaeological lime mortars surfaces
PublicationArchaeological traditional lime mortars are susceptible to many environmental conditions such as the impact of water (rain, humidity, groundwater, etc.), variation of temperatures' degrees, wind and/or pollution. Accordingly, this research aims to provide newly assessed multifunctional Nano-coating for the purpose of archaeological lime mortar protection. For this, the study combined physicochemical and mechanical characterizations...
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Adsorptive Removal of Aqueous Phase Crystal Violet Dye by Low-Cost Activated Carbon Obtained from Date Palm (L.) Dead Leaflets
PublicationUp to now, water pollution is still one of the important issues and challenges worldwide, due to its environmental, economic and human life impacts. It is also remains a challenge to environment scientists and technologists. Nowadays, the textile dyeing industry is considered one of the largest water consuming industries and produces large volumes of colored wastewater in its dyeing and finishing process. In this study, date palm...
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Micropatterning of BiVO 4 Thin Films Using Laser-Induced Crystallization
PublicationRelatively high temperatures even up to 500 °C are required to obtain bismuth vanadate (BiVO4) films with the scheelite monoclinic (s-m) structure that shows the highest photocatalytic activity. This requirement limits the possible choice of substrates. Moreover, high quality thin layers of crystalline BiVO4 cannot be prepared with current methods. In this study a light-induced crystallization approach is presented, which is a...