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Search results for: DNA OXIDATIVE DAMAGE
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TRNA-Leu (UUR) gene haplotypes observed in canine mammary gland tumours and its deleterious effect assessment according to the comparative analysis with TRNL1 human gene
Open Research DataThe aetiology and pathogenesis of many canine tumours are likely to be similar to cancers found in humans. This study aimed to present a plausible link between changes in tRNA-Leu (UUR) gene and the carcinogenesis process in dogs with mammary gland tumours. The whole mitochondrial DNA (mtDNA) isolated from blood and tumour tissues of 13 dogs with malig-nant...
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Determination of isoprostanes in exhaled breath condensate samples by liquid chromatography coupled with tandem mass spectrometry
PublicationOxidative stress (OS) is a state of imbalance between continuously generating reactive oxygen species (ROS) during normal cell metabolism and mechanism of detoxifying oxygen radicals through a network of antioxidative enzymes. Isoprostanes are prostaglandin -like substances that are produced in vivo primarily by free radical-induced peroxidation of arachidonic acid. The measurement of isoprostanes in biological fluids and/or tissue...
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Natural Products Counteracting Cardiotoxicity during Cancer Chemotherapy: The Special Case of Doxorubicin, a Comprehensive Review
PublicationCardiotoxicity is a frequent undesirable phenomenon observed during oncological treatment that limits the therapeutic dose of antitumor drugs and thus may decrease the effec-‐‑ tiveness of cancer eradication. Almost all antitumor drugs exhibit toxic properties towards cardiac muscle. One of the underlying causes of cardiotoxicity is stimulation of oxidative...
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Ocena odporności powłok na bazie DLC na doraźne uszkodzenie w warunkach tarcia ślizgowego ze smarowaniem wodą i solą fizjologiczną = Evaluation of DLC based coatings resistance to instanteneous damage under sliding friction conditions with distilated water or saline lubrication
PublicationWykonano serię testów w celu wyznaczenia granicznych warunków wymuszenia, zdefiniowaego jako średnie naciski powierzchniowe oraz prędkość ślizgania, po przekroczeniu których następuje gwałtowne zniszczenie powłoki. Na podstawie wyników pomiarów opracowano aproksymowane charakterystyki granicznych wymuszeń w układzie p - v oraz pokrewnych dla badanych materiałów, smarów i zakresu parametrów wymuszenia.
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Impact resistance of plain and twill fabric in GFRP measured by active thermography
PublicationThis paper discusses the impact resistance of glass-fibre reinforced polymer (GFRP) composites depending on the type of reinforcement – plain or twill weave. The values of impact energy were: 3J, 10J and 15J. Specimens featuring twill weave transferred higher force during the impact as compared with plain weave specimens. It was observed that an increase of impact energy was accompanied by an increase of the disproportion in...
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Strain energy density and entire fracture surface parameters relationship for LCF life prediction of additively manufactured 18Ni300 steel
PublicationIn this study, the connection between total strain energy density and fracture surface topography is investigated in additively manufactured maraging steel exposed to low-cycle fatigue loading. The specimens were fabricated using laser beam powder bed fusion (LB-PBF) and examined under fully-reversed strain-controlled setup at strain amplitudes scale from 0.3% to 1.0%. The post-mortem fracture surfaces were explored using a non-contact...
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Discrete element method simulations of fracture in concrete under uniaxial compression based on its real internal structure
PublicationThe paper describes experimental and numerical results of concrete fracture under quasi-static uniaxial compression. Experimental uniaxial compression tests were performed on concrete cubic specimens. Fracture in concrete was detected at the aggregate level by means of three non-destructive methods: three-dimensional X-ray microcomputed tomography, two-dimensional scanning electron microscope and manual two-dimensional digital...
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Mirosław Andrusiewicz prof. dr hab. n. med. i n. o zdr.
PeopleDiplomas, degrees conferred in specific areas ̶ Post-doctoral degree in medical sciences (doctor habilitated) (discipline: medical biology) December 4, 2017; Title of academic achievement: "Analysis of selected genes involved in the control of pathological changes in cells derived from internal female reproductive organs"; Poznan University of Medical Sciences, Faculty of Medicine II; re-viewers: Prof. Katarzyna Ziemnicka,...
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Qualitative analysis of phospholipids and their oxidised derivatives – used techniques and examples of their applications related to lipidomic research and food analysis
PublicationPhospholipids (PLs) are important biomolecules that not only constitute structural building blocks and scaffolds of cell and organelle membranes, but also play a vital role in cell biochemistry and physiology. Moreover, dietary exogenous PLs are characterized by high nutritional value and other beneficial health effects, which are confirmed by numerous epidemiological studies. For this reason, PLs are of high interest in lipidomics...
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Modeling of event trees for the rapid scenario development
PublicationThe paper concerns the safety of ships in abnormal/damage conditions. Some conclusions following from the research associated with development of a method for safety assessment of ships in abnormal/damage conditions is presented in the paper. The method called SSAMADC (Ship Safety Assessment Method in Abnormal/Damage Conditions) is a risk-based method and is connected with application of the quantitative risk assessment QRA approach....
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Improvement of the load capacity of the road overpass as a result of repairs after breakage caused by vehicle impacts
PublicationDamage of spans of the overpass caused by impact of underpassing vehicles are a frequent case. Objects that use prefabricated load-bearing elements that are not designed for such impacts are particularly exposed. After impact, such parts suffer extensive damage that need repair. Taking advantages of this recovery actions it is worth to perform strengthening that will protect object against possible future impacts. In this study...
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NONLINEAR VIBRATION ANALYSIS OF BEAM AND PLATE WITH CLOSED CRACK: A REVIEW
PublicationThe effect of nonlinearity is high sensitivity in damage detection, especially for closed cracks and delamination. This review illustrates the results of several researchers dealing with nonlinear effects caused by the closure of cracks in the structure, i.e., beam and plate structures. Early detection of damage is an important aspect for the structure and, therefore, continuous progress is being made in developing new and effective...
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A continual model of a damaged medium used for analyzing fatigue life of polycrystalline structural alloys under thermal–mechanical loading
PublicationThe main physical laws of thermal–plastic deformation and fatigue damage accumulation processes in polycrystalline structural alloys under various regimes of cyclic thermal–mechanical loading are considered. Within the framework of mechanics of damaged media, a mathematical model is developed that describes thermal–plastic deformation and fatigue damage accumulation processes under low-cycle loading. The model consists of three...
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Oxidative Dimerisierung von Phosphanen und Hinweise auf das intermediare Auftreten des Phosphinophosphinidens tBu2P-P in Reaktionen von [(eta^5^-C5H5)2TiCl2] und [(eta^5^-C5H5)(eta^5^-C5Me5)TiCl2] mit tBu2P-P(SiMe3)Li und tBu2P-P(Li)-P-tBu2. Bildung von Titan(III)- Fulvalen-Komplexen.
PublicationReakcja dichlorku tytanocenu z tBu2P-P(Li)-P-tBu2 albo tBu2P-P(SiMe3)Li prowadzi do kompleksów Ti(III). Jednocześnie grupy fosfanowe dimeryzują dając (tBu2P)2P-P(P-tBu2)2 lub (tBu2P-PSiMe3)2. Znaleźliśmy produkty, które sugerują przejściowe występowanie tBu2P-P.
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Międzyłańcuchowe sieciowanie DNA jako mechanizm biologicznego działania an- tracenodionów.**2003, 100 s. 30 rys. 20 tab. bibliogr. 110 poz. maszyn. Rozprawa doktorska /23.06.2003/ P. Gdań. Wydz. Chem. Promotor: prof. dr hab. inż. J. Konopa.
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Safety assessment of a concrete viaduct damaged by vehicle impact and an evaluation of the repair
PublicationDamage to lower parts of viaducts caused by impact from under-passing high vehicles is relatively frequent. One such incident, in which a viaduct was damaged by the impact from a truck with an improperly assembled hydraulic crane, is considered in this work. The analysis is based on a detailed object damage evaluation, 3D laser scanning, and numerical simulations. The aim of the study is to accurately model the vehicle impact into...
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Numerical FDM modelling of wave propagation in concrete structure
PublicationThe article presents application of finite difference method to damage detection and its size evaluation in concrete structure by elastic wave propagation method. The simulations of wave propagation in concrete structure were performed for six different damage scenarios. Damages were modelled as areas with changed material properties. Investigation focused on the influence of damage size on the energy of wave reflection. Presented...
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Changes in gene methylation patterns in neonatal murine hearts: Implications for the regenerative potential
PublicationBackground The neonatal murine heart is able to regenerate after severe injury; this capacity however, quickly diminishes and it is lost within the first week of life. DNA methylation is an epigenetic mechanism which plays a crucial role in development and gene expression regulation. Under investigation here are the changes in DNA methylation and gene expression patterns which accompany the loss of regenerative potential. Results The...
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Seabed characterisation using spectral moments of the echo signal
PublicationZbadano użyteczność zastosowania momentów spektralnych obwiedni echa w rozpoznawaniu i klasyfikacji dna morskiego. Przeprowadzono obliczenia momentów spektralnych dla około 15000 ech od dna zarejestrowanych w rejonie Bałtyku Południowego i potwierdzono tezę, że wartości tych momentów skorelowane są silnie z typem dna i rodzajem osadów.
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Abdalraheem Ijjeh Ph.D. Eng.
PeopleThe primary research areas of interest are artificial intelligence (AI), machine learning, deep learning, and computer vision, as well as modeling physical phenomena (i.e., guided waves in composite laminates). The research interests described above are utilized for SHM and NDE applications, namely damage detection and localization in composite materials.
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Shape-Depended Biological Properties of Ag3PO4 Microparticles: Evaluation of Antimicrobial Properties and Cytotoxicity in In Vitro Model—Safety Assessment of Potential Clinical Usage
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Isolation and Characterization of NP-POL Nonapeptide for Possible Therapeutic Use in Parkinson’s Disease
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Bardoxolone Methyl Displays Detrimental Effects on Endothelial Bioenergetics, Suppresses Endothelial ET-1 Release, and Increases Endothelial Permeability in Human Microvascular Endothelium
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Phytochemical Constituents, Biological Activities, and Health-Promoting Effects of the Melissa officinalis
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Elastic wave propagation for condition assessment of steel bar embedded in mortar
PublicationThis study deals with experimental and numerical investigations of elastic wave propagation in steel bars partially embedded in mortar. The bars with different bonding lengths were tested. Two types of damage were considered: damage of the steel bar and damage of the mortar. Longitudinal waves were excited by a piezoelectric actuator and a vibrometer was used to non-contact measurements of velocity signals. Numerical calculations...
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T cell Activation Is Driven by an ADP-Dependent Glukosinase Linking Enhanced Glycolysis with Mitochondrial Reactive Oxygen Species Generation
PublicationMitochondria-originating reactive oxygen species control T cell receptor (TCR)-induced gene expression. Here, we show that TCR-triggered activation of ADP-dependent glucokinase (ADPGK), an alternative, glycolytic enzyme typical for Archaea, mediates generation of the oxidative signal. We also show that ADPGK is localized in the endoplasmic reticulum and suggest that its active site protrudes toward the cytosol. The ADPGK-driven...
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Metylotransferazy ssaków – inhibitory i aktywatory
PublicationWśród metylotransferaz ssaków możemy wyróżnić metylotransferazy histonowe oraz metylotransferazy DNA. Metylacja DNA w obrębie wysp CpG oraz metylacja histonów wpływają na poziom ekspresji genów w komórkach ssaczych. Dodatkowo dzięki metylacji zapewniana jest stabilność i integralność genomu ludzkiego. Metylotransferazy DNA, będące głównym tematem tego artykułu, są często przedmiotem badań, gdyż nieprawidłowa metylacja DNA jest...
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DDLMS PCR double digestion Ligation Mediated Suppression PCR - a new technique for bacterial specific differentiation
PublicationA new diagnostic kit for K. oxytoca specific differentiation based on ddLMS PCR (ang. double digest ligation Mediated PCR) technique is shown. As a species-specific DNA fragment pehX gene, encoding the enzyme polygalactouronase, was chosen. The genome sequence of K. oxytoca is digested with two endonucleases: AclI and BclI which cut DNA before and after pehX gene. The polymorphic DNA fragments are ligated with AclI-end-specific...
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SELECTION OF DIAGNOSTIC FUNCTIONS IN A WHEELED TRACTOR
PublicationIn a classical approach to damage diagnosis, the technical condition of an analyzed machine is identified based on the measured symptoms, such as performance, thermal state or vibration parameters. In wheeled tractor the fundamental importance has monitoring and diagnostics during exploitation concerning technical inspection and fault element localizations. The main functions of a diagnostic system are: monitoring tractor components...
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Loop-mediated isothermal amplification (LAMP) as a diagnostic tool in detection of infectious diseases
PublicationLoop-mediated isothermal amplification (LAMP) is a gene amplification method which amplifies DNA with high specificity and efficiency under isothermal conditions. Because of its rapidity and simplicity, it is a valuable diagnostic tool in the early detection and identification of infectious diseases. LAMP method is based on the use of a set of four to six specially designed primers spanning six to eight distinct sequences on the...
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Types of wear and tear of biomaterials used in orthopaedic surgery
PublicationPurpose of this paper is presentation of observations on different kinds of wear and tear of biomaterials used in contemporary orthopaedic surgery. Types of prosthesis damage, encountered in medical practice, and their causes have been described. Results of many clinical studies were analysed to review prosthesis damage from the stage of implanting (such as intrusion of a foreign object between its components) to their natural...
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Sensitivity of echo parameters to seafloor properties and depth variability.
PublicationPrzeprowadzono badanie użyteczności wybranych parametrów echa akustycznego, w szczególności wymiaru fraktalnego oraz momentów spektralnych obwiedni, w klasyfikacji dna morskiego, ze szczególnym uwzględnieniem wpływu zmieniającej się głębokości. Wykorzystano numeryczną symulację rozpraszania echa na dnie oraz innych elementów procesu akustycznego sondowania dna, w tym także procedurę kompensacji wpływu zmian głębokości dna na echo.
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The antioxidative properties of white cabbage (Brassica oleracea var. capitata f. alba) fresh and submitted to culinary processing
PublicationKapusta biała stanowi jeden z podstawowych składników diety w Europie centralnej. W publikacji autorzy skupili się na określeniu właściwościach przeciwutleniających kapusty świeżej, kiszonej i poddanej obróbce termicznej. Te właściwości zostały oszacowane dla soków przy wykorzystaniu systemów pozakomórkowych, w komórkach HT29 pod kątem ochrony przed utlenieniem DNA oraz poprzez symulację GSTs i naprawę DNA. Wszystkie badane soki...
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GPR simulations for diagnostics of a reinforced concrete beam
PublicationThe most popular technique for modelling of an electromagnetic field, the finite difference time domain (FDTD) method, has recently become a popular technique as an interpretation tool for ground penetrating radar (GPR) measurements. The aim of this study is to detect the size and the position of damage in a reinforced concrete beam using GPR maps. Numerical simulations were carried out using the finite differ-ence time domain...
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Identification and cloning of C. albicans SC5314 genes encoding L-methionine biosynthetic pathway enzymes.
Open Research DataEnzymes of fungal L-methionine biosynthetic pathway: homoserine O-acetyltransferase (Met2p), O-acetylhomoserine sulfhydrylase (Met15p) and cystathionine-γ-synthase (Str2p) could be exploited as molecular targets for antifungal chemotherapy. The goal of the study was to identify and clone genes encoding mentioned above enzymes. MET2, MET15 and STR2 genes...
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The construction of bifunctional fusion proteins consisting of MutS and GFP
PublicationSkonstruowano białka chimeryczne zawierające białko MutS z Thermus thermophilus i białko zielonej fluoresceiny GFP z Aequorea victoria, posiadające dla łatwiejszego oczyszczania domeny oligo-histydynowe na N- lub C-końcu. Fuzyjne białka rozpoznawały niekomplementarności w DNA podobnie do MutS T. thermophilus. Fluorescencyjne białka rozpoznające niekomplementarne DNA mogą być użyteczne w wykrywaniu jednonukleotydowych polimorfizmów...
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Guided wave propagation in diagnostic of steel elements
PublicationThis paper is devoted to numerical investigations of elastic wave propagation in steel elements. The aim of this study is to conduct numerical analysis and experimental investigations on the propagation of elastic waves in steel elements in the context of damage detection. In particular, this paper is devoted to detection of damage occurring in the form of notch or changed thickness. This approach utilized the fact that any discontinuities...
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Guided wave propagation in diagnostic of steel elements
PublicationThis paper is devoted to numerical investigations of elastic wave propagation in steel elements. The aim of this study is to conduct numerical analysis and experimental investigations on the propagation of elastic waves in steel elements in the context of damage detection. In particular, this paper is devoted to detection of damage occurring in the form of notch or changed thickness. This approach utilized the fact that any discontinuities...
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PCR-ELISA: inexpensive alternative to quantitative PCR
PublicationPCR-ELISA (polymerase chain reaction-enzyme linked immunosorbent assay), a combination of PCR and ELISA methods, has been used since late 1980s. The technique is based on specially labelled DNA fragments which are captured by specific DNA sequences and detected by antibodies. The whole procedure of PCR-ELISA is divided into three steps: DNA extraction, PCR reaction and detection by ELISA. The method has been found as very specific...
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ADRENAL GLAND, Adrenal gland, NOS - Male, 71 - Tissue image [12030630017649991]
Open Research DataThis is the histopathological image of ADRENAL GLAND tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.
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Data Compression in Ultrasonic Network Communication via Sparse Signal Processing
PublicationThis document presents the approach of using compressed sensing in signal encoding and information transferring within a guided wave sensor network, comprised of specially designed frequency steerable acoustic transducers (FSATs). Wave propagation in a damaged plate was simulated using commercial FEM-based software COMSOL. Guided waves were excited by means of FSATs, characterized by the special shape of its electrodes, and modeled...
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HPLC-coupled post-column derivatization aims at characterization and monitoring of plant phytocomplexes, not at assessing their biological properties
PublicationTwo recent decades of research identified a number of environmental factors as well as mechanisms leading to pathogenic processes in the human organism. A common factor in pathogenesis of many diseases is oxidative stress, a condition in which the production of damaging reactive oxygen species (ROS), present in the body as an inevitable consequence of respiration and exacerbated by the inflammatory response and by exogenous factors...
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Marta Łabuda dr hab. inż.
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Endothelial Dysfunction Driven by Hypoxia—The Influence of Oxygen Deficiency on NO Bioavailability
PublicationCardiovascular diseases (CVDs) are the leading cause of death worldwide. The initial stage of CVDs is characterized by endothelial dysfunction, defined as the limited bioavailability of nitric oxide (NO). Thus, any factors that interfere with the synthesis or metabolism of NO in endothelial cells are involved in CVD pathogenesis. It is well established that hypoxia is both the triggering factor as well as the accompanying factor...
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Classification methods and criteria
PublicationKlasyfikacja akustyczna dna morskiego jest najnowszą metodologią zaprojektowaną w celu zdalnego wykrywania rozmaitych charakterystyk dna morskiego z informacji zawartych w echch od dna akustycznych impulsów transmitowanych z różnego typu sonarów. Poza szególnymi chrakterystykami sprzętowymi każdego systemu ASC, istotą każdej metody jest klasyfikacja modułu, który wyciąga serie cech z echa sygnału i przetwarza je aby posortować...
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Experience-Oriented Knowledge Management for Internet of Things
PublicationIn this paper, we propose a novel approach for knowledge management in Internet of Things. By utilizing Decisional DNA and deep learning technologies, our approach enables Internet of Things of experiential knowledge discovery, representation, reuse, and sharing among each other. Rather than using traditional machine learning and knowledge discovery methods, this approach focuses on capturing domain’s decisional events via Decisional...
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Benzonaza(R): możliwości praktycznych zastosowań.
PublicationBenzonaza znajduje zastosowanie w efektywnym obniżaniu lepkości i usuwaniu kwasów nukleinowych z roztworów białkowych. Zbadano w praktyce jej możliwości aplikacyjne w oczyszczaniu białek rekombinantowych wiążących jednoniciowe DNA (ang. SSB - single stranded DNA binding protein).
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Michał Szydłowski dr hab. inż.
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Możliwości zastosowań, potencjalne źródła oraz ewolucja technologiczna sposobu otrzymywania trehalozy ze szczególnym uwzględnieniem enzymu syntazy trehalozy [EC 5.4.99.16]
PublicationJedna z wiodących gałęzi współczesnej biotechnologii opiera się na produkcji białek – przede wszystkim enzymów. Są one powszechnie wykorzystywane: od przemysłu chemicznego poprzez przemysł spożywczy aż po medycynę i życie codzienne (czy ktoś wyobraża sobie w dzisiejszych czasach proszek do prania „bez enzymu”). Przed rozwojem nowoczesnych metod biologii molekularnej i inżynierii genetycznej pozyskiwano interesujące substancje z...
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Data on solutions of Hes1 system
Open Research DataHes1 protein (hairy and enhancer of split 1) belongs to the helix-loop-helix (bHLH) family of transcription proteins, i.e. DNA-binding proteins in the promoter region or in another region where regulation of transcription processes occurs. The database collects data on solutions of the Hes1 systems with multiple binding sites and the dimer formation...