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Search results for: duchenne muscular dystrophy (dmd)
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Stability Enhancement of Grid-Connected Wind Power Generation System Using PSS, SFCL and STATCOM
PublicationThe stability related issues may occur in a power system due to disturbances in generating or loading conditions, especially in the presence of distributed generation (DG) based on renewable energy resources (RERs). This paper proposes a novel strategy for the stability enhancement of a wind power generation system (WPGS) by using a combination of three devices, namely, a power system stabilizer (PSS), resistive superconductor...
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The Impact of Isocyanate Index and Filler Functionalities on the Performance of Flexible Foamed Polyurethane/Ground Tire Rubber Composites
PublicationThe structure and performance of polyurethane (PU) foams are strongly driven by the stoichiometry of the polyaddition reaction, quantitatively described by the isocyanate index. It determines the balance between isocyanate and hydroxyl groups in the reacting system and is affected by the introduction of additional functionalities originated, e.g., from applied fillers. Nevertheless, this issue is hardly taken into account in research...
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Remediation of soils on municipal rendering plant territories using Miscanthus × giganteus
PublicationPhytoremediation, as a cost-effective, highly efficient, environmentally friendly, and green approach, gained attention to the removal of metals, including heavy metals, from contaminated soils. The toxic nature of heavy metals can have an adverse effect on human health and the ecosystem, and their removal remains a worldwide problem. Therefore, in this study, a field experiment was carried out to evaluate the potential of Miscanthus × giganteus...
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Seismic gap between buildings founded on different soil types experiencing pounding during earthquakes
PublicationSeveral formulas have been suggested in the literature to evaluate the minimum seismic gap that would prevent collisions between adjacent buildings during earthquakes, including those based on the absolute sum of the peak displacements (ABS), square root of the sum of the squares (SRSS), the double difference method (DDC), Australian code, and approach proposed by Naderpour et al. The aim of the present study is to evaluate the...
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Significance of Dermoscopy in Association with Clinical Features in Differentiation of Basal Cell Carcinoma and Benign Trichoblastic Tumours
PublicationBackground: Although basal cell carcinoma (BCC) can, in the majority of cases, be diagnosed based on clinical and dermoscopic assessment, a potential overlap with benign adnexal skin tumours seems to exist, including trichoblastic tumours (TT). Methods: Retrospective analysis of clinical and dermoscopic features of benign TT and BCC cases was performed to develop a diagnostic algorithm with a potential utility in clinical practice....
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Universities’ journey towards sustainability- systematic literature review
PublicationPurpose: This research aims to identify a sustainable university's key features. It is an essential step in tracing the topics discussed in the context of a sustainable university and their evolution in the scientific discourse. Design/methodology/approach: This paper relies on a systematic literature review (SLR) conducted using two scholarly databases: Emerald and Scopus. The timeframe selected by the authors for reviewing the...
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Procedura przygotowania próbki do oznaczania wielopierścieniowych węglowodorów aromatycznych w produktach technicznych
PublicationW pracy opisano nową metodę przygotowania próbki w celu oznaczania śladowych zawartości wielopierścieniowych węglowodorów aromatycznych (WWA) w wysokowrzących produktach naftowych. Wartości granicy oznaczalności dla badanych WWA w materiałach tego typu mieściły się w przedziale od kilkudziesięciu ng/kg do poniżej dwudziestu ug/kg. Badania wykazały, że w celu oddzielenia większości zanieczyszczeń od analitów, bez ich znaczących...
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Pregnane X receptor dependent up-regulation of CYP2C9 and CYP3A4 in tumor cells by antitumor acridine agents, C-1748 and C-1305, selectively diminished under hypoxia
PublicationInduction of proteins involved in drug metabolism and in drug delivery has a significant impact on drug-drug interactions and on the final therapeutic effects. Two antitumor acridine derivatives selected for present studies, C-1748 (9-(2’-hydroxyethylamino)-4-methyl-1-nitroacridine) and C-1305 (5-dimethylaminopropylamino-8-hydroxy-triazoloacridinone), expressed high and low susceptibility to metabolic transformations with liver...
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Modulation of CYP3A4 activity and induction of apoptosis, necrosis and senescence by the antitumor imidazoacridinone C-1311 in human hepatoma cells
PublicationThere is increasing evidence that the expression level of drug metabolic enzymes affects the final cellular response following drug treatment. Moreover, anti-tumour agents may modulate enzymatic activity and/or cellular expression of metabolic enzymes in tumour cells. We investigated the influence of CYP3A4 overexpression on the cellular response induced by the anti-tumour agent C-1311 in hepatoma cells. C-1311-mediated CYP3A4...
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Job Demands, Engagement, and Turnover Intentions in Polish Nurses: The Role of Work-Family Interface
PublicationBackground: Poland has lower ratios of employed registered nurses per 1,000 inhabitants than the EU average. Polish nurses work under miserable conditions without assisting personnel, and they reconcile their professional demands with responsibilities for their families; 96% of them are women. Rationale/Aims: This study uses Hobfoll’s conservation of resources (CORs) theory to explain the role of various resources in the improvement...
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New Chalcones Derivatives With Potent Antitumor Activity And Their Metabolism In Vitro
PublicationChalcone derivatives exhibit a broad range of biological activities, with antioxidant and cytotoxic properties among the most studied. Despite numerous reports on chalcones as cytotoxic, and potentially anticancer agents, very little is know on their actual mechanism of activity. Generally, chalcones are considered as antimitotic agents, which interfere with tubulin assembly.We have recently developed a new class of chalcones with...
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Fabrication of ILs-Assisted AgTaO3 Nanoparticles for the Water Splitting Reaction: The Effect of ILs on Morphology and Photoactivity
PublicationThe design of an active, stable and ecient photocatalyst that is able to be used for hydrogen production is of great interest nowadays. Therefore, four methods of AgTaO3 perovskite synthesis, such as hydrothermal, solvothermal, sol-gel and solid state reactions, were proposed in this study to identify the one with the highest hydrogen generation eciency by the water splitting reaction. The comprehensive results clearly show that...
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Isolation of Bacteriocin-producing Staphylococcus spp. Strains from Human Skin Wounds, Soft Tissue Infections and Bovine Mastitis
PublicationA collection of 206 Staphylococcus spp. isolates was investigated for their ability to produce compounds exhibiting antistaphylococcal activity. This group included Staphylococcus aureus, Staphylococcus epidermidis, Staphylococcus xylosus strains recovered from bovine mastitis (n = 158) and human skin wounds and soft tissues infections (n = 48). Production of substances with antimicrobial activity was observed in six strains. Five...
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Host and pathogen factors in Klebsiella pneumoniae upper urinary tract infections in renal transplant patients
PublicationPurpose . To analyse the role of virulence factors (VFs) and host in Klebsiella pneumoniae upper urinary tract infections (UTIs) in renal transplant (RTx) recipients. Methodology. Clinical and demographic data were registered prospectively. Phylogenetic background of K. pneumoniae isolates was analysed by PCR melting profiles (MP) and the following VFs genes: fimH-1, uge, kpn, ycfM, mrkD, rmpA, magA, hlyA, cnf-1, irp-1, irp-2,...
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Spatial distribution of pharmaceuticals in conventional wastewater treatment plant with Sludge Treatment Reed Beds technology
PublicationPharmaceutical residues are an emerging environmental problem. It is strongly confirmed that pharmaceuticals are present in soils and environmental waters (surface, marine and even groundwater), and that wastewater treatment plant (WWTP) effluents are the main source of pharmaceuticals in the watershed. The aim of this studywas to recognize the spatial distribution and seasonal changes of selected pharmaceuticals in conventional WWTP...
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Effect of bio-based components on the chemical structure, thermal stability and mechanical properties of green thermoplastic polyurethane elastomers
PublicationIt seems to be obvious that conditions changes during polyols synthesis have impact on the polyols properties. Even the chemical formula is the same or similar, physicochemical properties and also molecular weight of polyols might be different and are significant in term of future polyurethanes properties and processing. In this work, fully bio-based poly(propylene succinate)s synthesized at different temperature conditions were...
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The relationship between standard reduction potentials of catechins and biological activities involved in redox control
PublicationRedox homeostasis involves factors that ensure proper function of cells. The excess reactive oxygen species (ROS) leads to oxidative stress and increased risk of oxidative damage to cellular components. In contrast, upon reductive stress, insufficient ROS abundance may result in faulty cell signalling. It may be expected that dietary antioxidants, depending on their standard reduction potentials (E°), will affect both scenarios....
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CPLFD-GDPT5: High-resolution gridded daily precipitation and temperature data set for two largest Polish river basins
PublicationThe CHASE-PL (Climate change impact assessment for selected sectors in Poland) Forcing Data–Gridded Daily Precipitation & Temperature Dataset–5 km (CPLFD-GDPT5) consists of 1951–2013 daily minimum and maximum air temperatures and precipitation totals interpolated onto a 5 km grid based on daily meteorological observations from the Institute of Meteorology and Water Management (IMGW-PIB; Polish stations), Deutscher Wetterdienst...
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An empirical study on the impact of AspectJ on software evolvability
PublicationSince its inception in 1996, aspect-oriented programming (AOP) has been believed to reduce the effort required to maintain software systems by replacing cross-cutting code with aspects. However, little convincing empirical evidence exists to support this claim, while several studies suggest that AOP brings new obstacles to maintainability. This paper discusses two experiments conducted to evaluate the impact of AspectJ (the most...
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Nowe rozwiązania w hydraulice przemysłu maszynowego - prace badawcze w Katedrze Hydrauliki i Pneumatyki
PublicationW referacie przedstawiono osiągnięcia Katedry Hydrauliki i Pneumatyki Politechniki Gdańskiej.W chwili obecnej uruchamiana jest produkcja pomp wielotłoczkowych PWK o stałej wydajności. Strategicznym celem jest zbudowanie jednostek o zmiennej wydajności. Hydrostatyczne zrównoważenie mechanizmu rozrządu pozwala bowiem zrealizować unikalny w skali światowej mechanizm bezpośredniego sterowania wydajnością pompy za pomocą elementu o...
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Are the short cationic lipopeptides bacterial membrane disruptors? Structure-Activity Relationship and molecular dynamic evaluation
PublicationShort cationic lipopeptides are amphiphilic molecules that exhibit antimicrobial activity mainly against Grampositives. These compounds bind to bacterial membranes and disrupt their integrity. Here we examine the structure-activity relation (SAR) of lysine-based lipopeptides, with a prospect to rationally design more active compounds. The presented study aims to explain how antimicrobial activity of lipopeptides is affected by...
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The energy-time method of estimating the work of ships' main propulsion with hydrodynamic transmission.
PublicationW referacie zasygnalizowano potrzebę, a zarazem problem badania układów napędowych (napędów głównych) statków ze śrubami nienastawnymi i nastawnymi oraz przekładniami hydrostatycznymi z pompami o zmiennej wydajności. Zaproponoano koncepcję badań energetycznych takich układów w celu ustalenia, które z tych rozwiązań napędów głównych statków może zapewnić większą sprawność takich napędów podczas ich pracy z różnymi naporami i prędkościami...
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A strong preference for the TA/TA dinucleotide step discovered for an acridine-based, potent antitumor dsDNA intercalator, C-1305: NMR-driven structural and sequence-specificity studies
PublicationTriazoloacridinone C-1305, a potent antitumor agent recommended for Phase I clinical trials, exhibits high activity towards a wide range of experimental colon carcinomas, in many cases associated with complete tumor regression. C-1305 is a well-established dsDNA intercalator, yet no information on its mode of binding into DNA is available to date. Herein, we present the NMR-driven and MD-refined reconstruction of the 3D structures...
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Application of the neural networks for developing new parametrization of the Tersoff potential for carbon
PublicationPenta-graphene (PG) is a 2D carbon allotrope composed of a layer of pentagons having sp2- and sp3-bonded carbon atoms. A study carried out in 2018 has shown that the parameterization of the Tersoff potential proposed in 2005 by Ehrhart and Able (T05 potential) performs better than other potentials available for carbon, being able to reproduce structural and mechanical properties of the PG. In this work, we tried to improve the...
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Glucosinolates from lepidium peruvianum as potential antiamnestic drugs
PublicationLepidium peruvianum (maca) (Brassicaceae) is a naturally occurring plant mainly in the high Andes of Peru. In recent years, it has been intensively researched in terms of its influence on various diseases and towards health improvement. Alzheimer’s disease is an incurable disease that most often affects adults over the age of 60. As since 2003 the US Food and Drug Administration (FDA) did not approve any new drug for Alzheimer’s...
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Effects of La0.8Sr0.2MnO3 and Ag electrodes on bismuth-oxide-based low-temperature solid electrolyte oxygen generators
PublicationIn this study, La0.8Sr0.2MnO3 (LSM) was used as the ceramic electrode in a (Bi1.50Y0.50)0.98Zr0.04O3+δ (BYO)-based solid electrolyte oxygen generator (SEOG) and its performance was compared with that of a previously studied high-fire Ag electrode. Among La0.6Sr0.4Co0.2Fe0.8O3, LaNi0.6Fe0.4O3, Cu1.4Mn1.6O4, and LSM materials, only LSM materials did not trigger any chemical reaction or interdiffusion with BYO at temperatures up to...
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Entrepreneurial intentions of students from Latvia, Poland, and Ukraine: The role of perceived entrepreneurial education results
PublicationOur main aim is to establish which factors influence entrepreneurial intentions, with a particular focus on the role of entrepreneurial education and university support in Central and Eastern European countries (CEE). To verify hypotheses quantitative research was conducted using surveys among 2,085 first-year undergraduate students from three technical universities in three countries: Latvia, Poland and Ukraine. The results of...
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Role of buttering layer composition on microstructural heterogeneity and mechanical properties of Alloy 617 and P92 steel dissimilar welded joints for future Indian AUSC program
PublicationRestrictive operating conditions (even exceeding 700 °C) of materials in advanced ultra super critical (AUSC) power plants and the need to minimize manufacturing and maintenance costs require the production of dissimilar metal welded joints (DMW). Significant differences in the physical and chemical properties of welded materials lead to phenomena that reduce the weldability of the metals used and force the search for solutions...
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Analysis of IPv6 handovers in IEEE 802.16 environment
PublicationThe second generation of WiMAX solutions, based on IEEE 802.16-2005 standard, offers limited mobility support. Unfortunately, after quickly changing the point of attachment on the WiMAX data link layer (DLL), very slow and inefficient IPv6 reconfiguration takes place. Delays introduced by automatic configuration (DHCPv6 and IPv6 protocols) and Mobile IPv6 can easily diminish or even render useless all benefits gained using the...
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Atimicrobial Resistance of Enterococcus spp. in Muncipal wasterwater Treatment Plant - Model Study
PublicationIn this study the removal of resistant Enterococcus spp. was evaluated using the laboratory-scale wastewater treatment model plant (M-WWTP), designed as a multiphase (anaerobic, anoxic and aerobic) system (Q = 27 dm3 per day) and continuously supplied with the wastewater obtained from the full-scale WWTP, after grid. The activated sludge from the secondary clarifier was recirculated to the anaerobic chamber (with the ratio equal...
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Prime-Boost Vaccination with Toxoplasma Lysate Antigen, but Not with a Mixture of Recombinant Protein Antigens, Leads to Reduction of Brain Cyst Formation in BALB/c Mice
PublicationIntroduction Infection with the ubiquitous parasite Toxoplasma gondii is a threat for immunocompro- mised patients and pregnant women and effective immune-prophylaxis is still lacking. Methods Here we tested a mixture of recombinant T . gondii antigens expressed in different develop- mental stages, i.e., SAG1, MAG1 and GRA7 (SMG), and a lysate derived from T . gondii tachyzoites (TLA) for prophylactic vaccination against cyst formation....
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UUV and AUV Vehicles as the autonomous systems for naval applications
PublicationThere is a growing pressure to investigate how to design and build the unmanned underwater vehicles of different types which are devoted towards performing many tasks under the water surface according to the data missions. During the recent years the Department of Ship Design and Subsea Robotics, Faculty of Ocean Engineering and Ship Technology, Gdansk University of Technology designed and built a few types of unmanned underwater...
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Methodology for Processing of 3D Multibeam Sonar Big Data for Comparative Navigation
PublicationAutonomous navigation is an important task for unmanned vehicles operating both on the surface and underwater. A sophisticated solution for autonomous non-global navigational satellite system navigation is comparative (terrain reference) navigation. We present a method for fast processing of 3D multibeam sonar data to make depth area comparable with depth areas from bathymetric electronic navigational charts as source maps during...
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New Unsymmetrical Bisacridine Derivatives Noncovalently Attached to Quaternary Quantum Dots Improve Cancer Therapy by Enhancing Cytotoxicity toward Cancer Cells and Protecting Normal Cells
PublicationThe use of nanoparticles for the controlled drug delivery to cells has emerged as a good alternative to traditional systemic delivery. Quantum dots (QDs) offer potentially invaluable societal benefits such as drug targeting and in vivo biomedical imaging. In contrast, QDs may also pose risks to human health and the environment under certain conditions. Here, we demonstrated that unique combination of nanocrystals core components...
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Impact of inorganic ions and pH variations on toxicity and endocrine potential of selected environmentally relevant pharmaceuticals
PublicationAssessment of the impact of pharmaceutical residues on living organisms is a very complex subject. Apart from taking into account the toxicity of individual compounds, environmental factors should also be taken into account. In this paper, attempts were made to assess the impact of coexisting inorganic ions and changes in pH on the toxicity of ten selected pharmaceuticals. Two bioassays were used to measure the estrogenic and androgenic...
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Increased inspiratory resistance affects the dynamic relationship between blood pressure changes and subarachnoid space width oscillations
PublicationBackground and objective Respiration is known to affect cerebrospinal fluid (CSF) movement. We hypothesised that increased inspiratory resistance would affect the dynamic relationship between blood pressure (BP) changes and subarachnoid space width (SAS) oscillations. Methods Experiments were performed in a group of 20 healthy volunteers undergoing controlled intermittent Mueller Manoeuvres (the key characteristic of the procedure...
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Deep eutectic solvents – Ideal solution for clean air or hidden danger?
PublicationThe industrial sector is one of the fastest-growing sources of greenhouse gases, due to its excessive energy consumption to meet the rapidly growing demand for energy-intensive products. The use of deep eutectic solvents (DESs) has been studied extensively in order to cope with these harmful gases, but their usage can be an issue in respect to ecological reasons. Do deep eutectic solvents harm the atmosphere? Yes, these solvents...
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The speciation of organotin compounds in sediment and water samples from the port of Gdynia
PublicationOrganotin compounds (OTC) are toxic towards all living organisms. The application of organitin-based antifouling systems is becoming the main source of OTC in the ocean. Harbor sediments and water contain large deposits of organotin compounds due to application of antifouling systems in the shipping industry. OTC contamination presents a potential risk to the marine environment. Sediment and water samples were collected in 2009...
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Effects of the Origin and Deacetylation Degree of Chitosan on Properties of Its Coatings on Titanium
PublicationThe properties of chitosan coatings on titanium surfaces may be influenced by a variety of factors, including their chemical characteristics and the deposition method. The aim of this research was to determine the influence of a chitosan’s origin (a type of shrimp) and deacetylation degree (DD), when deposited on a very smooth titanium surface, on adhesion and biological behavior. The tests were performed using chitosan of a degree...
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Sludge Treatment Reed Beds (STRBs) as a Eco-solution of Sludge Utilization for Local Wastewater Treatment Plants
PublicationSewage sludge is a by-product of wastewater treatment processes. In Poland, the amout of sewage sludge has been still growing in recent years, due to inhencement of pollutants removal in wastewater treatment plants (WWTPs). One of the systems used to transform sewage sludge into fertilizer is a technology called Sludge Treatment Reed Beds (STRBs). Reed systems are periodically irrigated with sewage sludge with a low dry matter...
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Phytoextraction and recovery of rare earth elements using willow (Salix spp.)
PublicationSoil and water contaminations are caused by rare earth elements (REEs) due to mining and industrial activities, that threaten the ecosystem and human health. Therefore, phytoremediation methods need to be developed to overcome this problem. To date, little research has been conducted concerning the phytoremediation potential of Salix for REEs. In this study, two Salix species (Salix myrsinifolia and Salix schwerinii) and two Salix...
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Graphene-based Silicone rubber Nanocomposites: Preparation, Characterization, and Properties
PublicationThis study aims to understand better the mechanical, thermal, and tribological behavior of silicone rubber nanocomposites. Graphite, exfoliated graphite, reduced graphene oxide, ionic liquid modified graphene oxide, silane-modified graphene oxide, fumed silica, and other fillers were used in this study. Adding graphene-based fillers to the silicone rubber matrix substantially improves the nanocomposite's mechanical, thermal, and...
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Insulin-like growth factor type 2 is better than insulin-like growth factor type 1 a survival marker in patients after acute decompensation of heart failure
PublicationIntroduction:A decreased IGF-1 has been found in heart failure (HF). There are no reports assessing IGF-2 in HF, although in vitro study has shown, that IGF-2 stimulates cardiomyocyte proliferation more than IGF-1. The study aim was to compare the IGF-1 and IGF-2 concentration depending on HF exacerbation and annual survival.Material and methods:Among 75 patients hospitalized...
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SUICIDES FOR ECONOMIC REASONS AS A MEASURE OF THE STATE OF THE ECONOMY: THE CASE OF POLAND
PublicationSuicides are a phenomenon observed in many countries. The causes of a decision so drastic as far as consequences are concerned include i.a. economic reasons. The question arises whether the changing number of suicides reflects the state of the economy. The direct link between the state of the economy and suicides has not been sufficiently studied so far. The authors of this article attempted to identify the links between selected...
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Improved-Efficacy EM-Based Antenna Miniaturization by Multi-Fidelity Simulations and Objective Function Adaptation
PublicationThe growing demands for integration of surface mount design (SMD) antennas into miniatur-ized electronic devices have been continuously imposing limitations on the structure dimen-sions. Examples include embedded antennas in applications such as on-board devices, picosatel-lites, 5G communications, or implantable and wearable devices. The demands for size reduction while ensuring a satisfactory level of the electrical and field...
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Lighting conditions in home office and occupant’s perception: Exploring drivers of satisfaction
PublicationThis paper depicts lighting home office conditions within different countries and continents, emphasizing the user’s satisfaction with the visual environment. The scope of this article is to investigate the drivers of participants’ satisfaction with the lighting conditions at the home office. The study was developed by a team of international experts working together on Subtask A: User perspective and requirements, Task 61 IEA...
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Magnetically recyclable TiO2/MXene/MnFe2O4 photocatalyst for enhanced peroxymonosulphate-assisted photocatalytic degradation of carbamazepine and ibuprofen under simulated solar light
PublicationIn this study, a novel TiO2/Ti3C2/MnFe2O4 magnetic photocatalyst with dual properties, enabling (i) improved photocatalytic degradation with PMS activation under simulated solar light and (ii) magnetic separation after the degradation process in an external magnetic field was developed and applied for the efficient photodegradation pharmaceutically active compounds (PhACs) frequently present in wastewater and surface waters worldwide. MXene...
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Hypericum alpestre extract exhibits in vitro and in vivo anticancer properties by regulating the cellular antioxidant system and metabolic pathway of L‐arginine
PublicationConventional treatment methods are not effective enough to fight the rapid increase in cancer cases. The interest is increasing in the investigation of herbal sources for the development of new anticancer therapeutics. This study aims to investigate the antitumor capacity of Hypericum alpestre (H. alpestre) extract in vitro and in vivo, either alone or in combination with the inhibitors of the L‐arginine/polyamine/nitric oxide...
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Effect of Maximal Apnoea Easy-Going and Struggle Phases on Subarachnoid Width and Pial Artery Pulsation in Elite Breath-Hold Divers
PublicationPurpose: The aim of the study was to assess changes in subarachnoid space width (sas-TQ), the marker of intracranial pressure (ICP), pial artery pulsation (cc-TQ) and cardiac contribution to blood pressure (BP), cerebral blood flow velocity (CBFV) and cc-TQ oscillations throughout the maximal breath hold in elite apnoea divers. Non-invasive assessment of sas-TQ and cc-TQ became possible due to recently developed method based on...
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Quantum dots conjugates with unsymmetrical bisacridines enhance cytotoxicity of these antitumor compounds in lung cancer cells and have protecting effects on normal cells
PublicationBackground: In recent years, with the rapid development of nanotechnology and its extensive applications in the medicine, nanocarriers for anticancer drug delivery have gained a great importance. Spherical semiconductor nanocrystals, frequently called quantum dots (QDs) are very attractive nanomaterials for bioimaging applications and they possess properties as potential candidates for drug carrier. Unsymmetrical bisacridines (UAs),...