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Search results for: secondary metabolites
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Cure kinetics of epoxy/MWCNTs nanocomposites: Isothermal calorimetric and rheological analyses
PublicationA combinatorial route has been applied in cure kinetics study of epoxy nanocomposites containing multi-walled carbon nanotubes (MWCNTs) based on differential scanning calorimetry and rheokinetic analyses under isothermal conditions. Pristine and amine-modified MWCNTs bearing primary and secondary amines were used at very low concentrations (0.1 and 0.3 wt.% based on epoxy weight). Model-free and model-fitting methods were applied...
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Reception of GNSS Signals Under Jamming Conditions
PublicationThe article focuses on performance of Global Navigation Satellite System receivers in environment where intentional interference is present. First part is a general description of GNSS systems. Secondly, types of positioning service disturbances are specified. In the third part authors present a scheme of measurement stand which is used to evaluate the influence of interference on reception of navigation signals. Next, research...
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Paenibacillus alvei MP1 as a Producer of the Proteinaceous Compound with Activity against Important Human Pathogens, Including Staphylococcus aureus and Listeria monocytogenes
PublicationAn emerging need for new classes of antibiotics is, on the one hand, evident as antimicrobial resistance continues to rise. On the other hand, the awareness of the pros and cons of chemically synthesized compounds’ extensive use leads to a search for new metabolites in already known reservoirs. Previous research showed that Paenibacillus strain (P. alvei MP1) recovered from a buckwheat honey sample presented a wide spectrum of...
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Bioactivities of Phenolic Compounds from Kiwifruit and Persimmon
PublicationFruit used in the common human diet in general, and kiwifruit and persimmon particularly, displays health properties in the prevention of heart disease. This study describes a combination of bioactivity, multivariate data analyses and fluorescence measurements for the differentiating of kiwifruit and persimmon, their quenching and antioxidant properties. The metabolic differences are shown, as well in the results of bioactivities...
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Mechanism-based inactivation of human cytochrome P450 1A2 and 3A4 isoenzymes by antitumor triazoloacridinone C-1305.
Publication5-Dimethylaminopropylamino-8-hydroxytriazoloacridinone, C-1305, is a promising antitumor therapeutic agent with high activity against several experimental tumors. It was determined to be a potent and selective inhibitor of liver microsomal and human recombinant cytochrome P450 (CYP) 1A2 and 3A4 isoenzymes. Therefore, C-1305 might modulate the effectiveness of other drugs used in multidrug therapy. The objective of this study was...
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Clean gas technologies - towards zero-emission repowering of Pomerania.
PublicationThe main aim this work is to show the different thermodynamic cycles which improve efficiency and/or decrease emission like: Cheng cycle, Szewalski cycle, LOTHECO cycle, hybrid pSOFC/GT cycle, inverse Brayton cycle, low-emission cycle and zero-emission cycle. For that purpose, cycles and results of analysis are first studied and, secondly, new concept is presented. The role of coupled analysis 0D and 3D in cycle’s devices is also...
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Self-optimizing narrowband interference canceller - can reference signal help?
PublicationSONIC (Self-Optimizing Narrowband Interference Canceller) is an acronym of the recently proposed active noise control algorithm with interesting adaptivity and robustness properties. SONIC is a purely feedback controller, capable of rejecting nonstationary sinusoidal disturbances (with time-varying amplitudes and/or frequencies) in the presence of plant (secondary path) uncertainties. We show that even though SONIC can work reliably...
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Pendant Proton-Relays Systematically Tune the Rate and Selectivity of Electrocatalytic Ammonia Generation in a Fe-Porphyrin Based Metal-Organic Framework
PublicationElectrocatalytic nitrite reduction (eNO2RR) is a promising alternative route to produce ammonia (NH3). Until now, several molecular catalysts have shown capability to homogeneously reduce nitrite to NH3, while taking advantage of added secondary-sphere functionalities to direct catalytic performance. Yet, realizing such control over heterogeneous electrocatalytic surfaces remains a challenge. Herein, we demonstrate that heterogenization...
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Waste Tyres Pyrolysis for Obtaining Limonene
PublicationThis review deals with the technologies of limonene production from waste tyre pyrolysis. Thermal decomposition is attractive for tackling the waste tyre disposal problem, as it enables both: energy to be recovered and limonene to be obtained. This material management recycling of tyres is environmentally more beneficial than the burning of all valuable products, including limonene. Given this recoverability of materials from waste...
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Bile conjugation and its effect on in vitro lipolysis of emulsions
PublicationBile Salts (BS) are responsible for stimulating lipid digestion in our organism. Gut microbiota are responsible for the deconjugation process of primary conjugated to secondary unconjugated BS. We use two structurally distinct BS and characterize the rate of lipolysis as a compound parameter. A static in-vitro digestion model as well as meta-analysis of literature data has been performed to determine the most influential factors...
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MP3vec: A Reusable Machine-Constructed Feature Representation for Protein Sequences
Publication—Machine Learning (ML) methods have been used with varying degrees of success on protein prediction tasks, with two inherent limitations. First, prediction performance often depends upon the features extracted from the proteins. Second, experimental data may be insufficient to construct reliable ML models. Here we introduce MP3vec, a transferable representation for protein sequences that is designed to be used specifically for sequence-to-sequence...
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Nano-structured Pt embedded in acidic salts of heteropolymolybdate matrices: MS EXAFS study
PublicationA structural study of Pt nano-catalysts is presented in the paper. The innovation in the case of the considered catalytic materials resides in the use a meso-microporous inorganic matrix of heteropolyacid salt of composition X2.5H0.5YMo12O40 where X = Rb, Cs and Y = P, Si as a catalyst support. Metallic nanoparticles were created by platinum ions reduction in a hot H2/Argon stream and were mainly located into matrix pores. As the...
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Transportable, Portable and Micro Gas Chromatographs
PublicationSignificant benefits can be obtained by miniaturization of conventional benchtop gas chromatographs. The attractive features arising from miniaturization include low-power requirements, low heat capacity of separation columns, low consumption of mobile phase, enhanced performance, higher portability, and easily coupling to detectors and secondary chromatographic systems. In separation sciences, including gas phase separations,...
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Solvation of ionic liquids based on N-alkyl-N-methylmorpholinium cations in N,N-dimethylformamide and dimethyl sulfoxide – A volumetric and acoustic study
PublicationApparent molar volumes and molar isentropic compressibilities for N-ethyl-N-methylmorpholinium and N-decyl-N-methylmorpholinium tetrafluoroborates in N,N-dimethylformamide (DMF) and dimethyl sulfoxide (DMSO) have been determined from density and speed of sound measurements over the temperature range T = (298.15, 303.15, 308.15, 313.15, 318.15 and 328.15) K at experimental pressure p = 0.1 MPa. This data has been used to calculate...
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Crack propoagation in MgO-PSZ ceramic materials
PublicationThe properties of ceramic materials such as elevated hardness, high temperature capability, low coefficient of thermal expansion are of interest for rolling element materials. Widely used ceramic materials in engineering applications are silicon nitride, zirconia and alumina. The paper presents an experimental study of the fatigue life of MgO-PSZ ceramic material in lubricated contact with defined types of cracks. A ceramic angular...
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The role and scope of architectural and conservation research procedures in the process of restoring the splendour of an architectural monument created after 1945 on the example of the Suburban Railway Station in Gdynia
PublicationModern Movement buildings, despite their relatively recent construction, are sometimes affected by radical transformations of layout and form. The railway stations being one of the most important public buildings in the city are a special group of them. Due to long-term and intensive use they may bear the signs of exploitation of parts of its substance and have secondary transformations disharmony with the building. The subject...
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Characterization of the fate of lipids in activated sludge
PublicationPrzeprowadzono doświadczenie wykazujące transformację lipidów w aerobowych warunkach osadu czynnego. Wykazano, że całkowitej, początkowej zawartości lipidów (2000 mg/l) nie udało się obniżyć do wartości niższej niż 300 mg/l. Jednakże, zawartość poszczególnych kwasów tłuszczowych uległa drastycznym zmianom, zarówno spadkowi, jak i wzrostowi podczas wszystkich faz wzrostu mikrobiologicznego. Obserwowane zmiany zawartości indywidualnych...
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Myrosinase activity in different plant samples; optimisation of measurement conditions for spectrophotometric and pH-stat methods
PublicationMyrosinase found in Brassicaceae plants, is the enzyme responsible for hydrolysis of glucosinolates. As a result a variety of biologically active metabolites are liberated, whose importance in crop protection and especially in cancer chemoprevention is rapidly gaining recognition. The growing practical application of glucosinolate degradation products requires that sensitive and reliable methods of myrosinase activity determination...
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Novel 2-alkythio-4-chloro-N-[imino(heteroaryl)methyl]benzenesulfonamide Derivatives: Synthesis, Molecular Structure, Anticancer Activity and Metabolic Stability
PublicationA series of novel 2-alkythio-4-chloro-N-[imino-(heteroaryl)methyl]benzenesulfonamide derivatives, 8–24, were synthesized in the reaction of the N-(benzenesulfonyl)cyanamide potassium salts 1–7 with the appropriate mercaptoheterocycles. All the synthesized compounds were evaluated for their anticancer activity in HeLa, HCT-116 and MCF-7 cell lines. The most promising compounds, 11–13, molecular hybrids containing benzenesulfonamide...
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Postbiotics in oncology: science or science fiction?
PublicationThe gut microbiome has been increasingly understood to play a critical role in carcinogenesis and cancer disease progression. The most recent research advancements have shown that different tools of microbiota manipulation contribute to gut microbiome–immune–oncology axis modulation, offering exciting opportunities for targeted interventions aimed at improving the efficacy of established anti-cancer therapy. Postbiotics are a new...
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Multivariate Statistical Approach for Nephrines in Womenwith Obesity
PublicationCatecholamines are physiological regulators of carbohydrate and lipid metabolism during stress, but their chronic influence on metabolic changes in obese patients is still not clarified. The present study aimed to establish the associations between the catecholamine metabolites and metabolic syndrome (MS) components in obese women as well as to reveal the possible hidden subgroups of patients through hierarchical cluster analysis...
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Identification of novel psychoactive substances 25B-NBOMe and 4-CMC in biological material using HPLC-Q-TOF-MS and their quantification in blood using UPLC–MS/MS in case of severe intoxications
PublicationThis paper describes cases of poisoning caused by new psychoactive substances such as: 25BNBOMe (2-(4-bromo-2,5-dimethoxyphenyl)-N-[(2-methoxyphenyl)methyl]ethanamine) and 4-CMC (1-(4-chlorophenyl)-2-(methylamino)-1-propanone). The analytical procedure includes rapid and selective method for the extraction and determination of 4-CMC and 25B-NBOMe in blood samples using UPLC–MS/MS technique. To the best of our knowledge,this is...
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The treatment of wastewater containing pharmaceuticals in microcosm constructed wetlands: the occurrence of integrons (int1–2) and associated resistance genes (sul1–3, qacEΔ1)
PublicationThe aim of this study was to analyze the occurrence of sulfonamide resistance genes (sul1–3) and other genetic elements as antiseptic resistance gene (qacEΔ1) and class 1 and class 2 integrons (int1–2) in the upper layer of substrate and in the effluent of microcosm constructed wetlands (CWs) treating artificial wastewater containing diclofenac and sulfamethoxazole (SMX), which is a sulfonamide antibiotic. The bacteria in the substrate...
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Carbon nanowalls: A new versatile graphene based interface for laser desorption/ionization-mass spectrometry detection of small compounds in real samples.
PublicationCarbon nanowalls, vertically aligned graphene nanosheets, attract attention owing to their tunable band-gap, high conductivity, high mechanical robustness, high optical absorbance and other remarkable properties. In this paper, we report for the first time, the use of hydrophobic boron-doped carbon nanowalls (CNWs) for laser desorption/ionization of small compounds and their subsequent detection by mass spectrometry (LDI-MS). The...
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Wykorzystanie wiązań niekowalencyjnych do otrzymywania jedno- i dwuskładnikowych struktur supramolekularnych
PublicationPrzedstawiona rozprawa doktorska dotyczy badań nad wykorzystaniem oddziaływań międzycząsteczkowych do projektowania i syntezy uporządkowanych struktur krystalicznych, ze szczególnym uwzględnieniem wiązań halogenowych i chalkogenowych jako stosunkowo nowych i bardzo atrakcyjnych z punktu widzenia inżynierii kryształu. Praca podzielona jest na kilka części. Pierwsza z nich stanowi wstęp teoretyczny obejmujący opis, założenia oraz...
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Biological fluids as a source of information on the exposure of man to envinonmental chemical agents.
PublicationWiele związków (min. lotne związki chlorowcoorganiczne, metale) ma szkodliwy wpływ na tkanki i narządy organizmu ludzkiego, wywołując nieodwracalne zmiany chorobowe. W celu określenia zagrożenia zawodowego coraz częściej wykonuje się pomiar stężeń substancji chemicznych i ich metabolitów w płynach biologicznych - moczu, krwi, rzadziej w mleku matki, żółci, ślinie, czy też spermie. Aby oznaczyć poziomy tych stężeń, pobrane próbki...
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Badania poziomów zanieczyszczeń w płynach ustrojowych człowieka. Study of the level of pollution in human body fluids
PublicationŹródłem informacji o stanie środowiska mogą być zarówno wyniki badań próbek części nieożywionej (woda, gleba, powietrze) jak i próbki części biotycznej, w tym także tkanek i płynów ustrojowych człowieka, który jest nieustannie narażony na działanie szerokiego spektrum ksenobiotyków. W niniejszej pracy przedstawiono przegląd metod izolacji, wzbogacania i technik oznaczeń końcowych analitów z próbek moczu ludzkiego i krwi. Zawarto...
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Forced Degradation Studies of Ivabradine and In Silico Toxicology Predictions for Its New Designated Impurities
PublicationAll activities should aim to eliminate genotoxic impurities and/or protect the API against degradation. There is a necessity to monitor impurities from all classification groups, hence ivabradine forced degradation studies were performed. Ivabradine was proved to be quite durable active substance, but still new and with insufficient stability data. Increased temperature, acid, base, oxidation reagents and light were found to cause...
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Automatic classification and mapping of the seabed using airborne LiDAR bathymetry
PublicationShallow coastal areas are among the most inhabited areas and are valuable for biodiversity, recreation and the economy. Due to climate change and sea level rise, sustainable management of coastal areas involves extensive exploration, monitoring, and protection. Current high-resolution remote sensing methods for monitoring these areas include bathymetric LiDAR. Therefore, this study presents a novel methodological approach to assess...
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Hybrid SONIC: joint feedforward–feedback narrowband interference canceler
PublicationSONIC (self-optimizing narrowband interference canceler) is an acronym of a recently proposed active noise control algorithm with interesting adaptivity and robustness properties. SONIC is a purely feedback controller, capable of rejecting nonstationary sinusoidal disturbances (with time-varying amplitude and/or frequency) in the presence of plant (secondary path) uncertainty. We show that although SONIC can work reliably without...
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Initial Investigation of Wave Interactions During Simultaneous Valve Closures in Hydraulic Piping Systems
PublicationThe effects of interference of pressure waves in simple piping systems were studied. A freeware computer code Allievi developed at the University of Valencia was used to simulate dynamic waveforms in simple and complex networks. The tests were carried out according to three scenarios. No pressure increases significantly exceeding the Joukowsky pressure in simple cases were noticed. When the effects of the simultaneous closing of...
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Innovative Bidirectional Isolated High-Power Density On-Board Charge for Vehicle-to-Grid
PublicationThis paper deals with developing and implementing a bidirectional galvanically isolated on-board charger of a high-power density. The power density of the new charger was 4 kW/kg and 2.46 kW/dm3, and the maximum efficiency was 96.4% at 3.4 kW. Due to the requirement to achieve a high-power density, a single-stage inverter topology was used. Regarding switching losses, due to the topology of the circuit with so-called hard switching,...
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Profiling and Qualitative Assessment of Enzymatically and Thermally Oxidized Egg Yolk Phospholipids using a Two‐Step High‐Performance Liquid Chromatography Protocol
PublicationA two‐step high‐performance liquid chromatography (HPLC) method for the profiling and qualitative assessment of oxidized phospholipids (oxPL) present in foods was developed. The applicability of the investigated two‐step HPLC protocol was verified for separation of enzymatically and thermally oxidized hen egg yolk phospholipids (PL) as a relevant food model. In the first step, seven individual PL classes were separated using hydrophilic...
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Biosynthetic and synthetic access to amino sugars.
PublicationAmino sugars are important constituents of a number of biomacromolecules and products of mi crobial secondary metabolism, including antibiotics. For most of them, the amino group is located at the positions C1, C2 or C3 of the hexose or pentose ring. In biological systems, amino sugars are formed due to the catalytic activity of specific aminotransferases or amidotransferases by introducing an amino functionality derived from L-glutamate...
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Chapel at St. Joseph's Church in Gdańsk
PublicationThe subject of this article is the chapel located in the former Gdańsk Carmelite monastery complex. The results of the architectural research carried out in it in 2014–2015 are presented. As a result, the time and purpose of the building’s construction were established. The original appearance and traces of later alterations were also recognised. The recesses found on the longitudinal walls, of similar dimensions, not reaching...
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Pesticides in precipitation - a review of data from 1975 to 2001 = Stężenia pestycydów w opadach atmosferycznych w latach 1975-2001
PublicationZebrano i opracowano dane literaturowe dotyczące trwałości w środowisku, metodyki analitycznej i przede wszystkim wyników badań pestycydów występujących w próbkach opadów atmosferycznych w różnych regionach. Przeprowadzono analizę danych i przedstawiono stan zanieczyszczenia wód opadowych pestycydami w okresie 1975-2001 na terenie Europy i Ameryki Północnej. Z zebranych danych wynika, że pestycydy występują wszędzie, nie tylko...
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Rola i znaczenie zbiornika sieciowego w kształtowaniu hydrauliki i jakości wody w systemie wodociągowym
PublicationEksploatacja zbiornika sieciowego powinna zapewniać cykliczną wymianę wody w jego komorach. Koniecznym warunkiem prawidłowej eksploatacji zbiornika jest zgodność założeń projektowych ze stanem faktycznym. Praktyka eksploatacyjna wskazuje na szereg nieprawidłowości w tym względzie. Z powodu lokalizacji zbiornika sieciowego za nisko lub za wysoko albo wskutek błędów popełnionych w ustaleniu jego parametrów obserwuje się niestabilność...
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Analiza sterowania ułamkowego PIλDμ mocą reaktora jądrowego
PublicationW artykule przedstawiono syntezę regulatora PIλDμ niecałkowitego rzędu dla potrzeb sterowania mocą reaktora jądrowego lekko wodnego określanego, jako typu PWR (Pressurized Water Reactor). W tym celu wykorzystano nieliniowy model matematyczny reaktora PWR o parametrach skupionych obejmujący procesy generacji i wymiany ciepła oraz termicznych efektów reaktywnościowych. Nastawy regulatora PIλDμ niecałkowitego rzędu dobrano w sposób...
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Spektrometria mas jako narzędzie umożliwiające poznanie metabolomu-główne strategie i wyzwania
PublicationBadania z zakresu metabolomiki ukierunkowane są na wykrywanie i oznaczanie endogennych związków małocząsteczkowych o masie <1000 Da (np. aminokwasy, cukry, lipidy) w próbkach biologicznych takich jak płyny biologiczne (głównie krew i mocz) oraz kondensaty wydychanego powietrza. Ze względu na szerokie spektrum występowania i niskie poziomy stężeń metabolitów w próbkach, analizy metabolomiczne wymagają stosowania technik o wysokiej...
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Silicon’s Influence on Polyphenol and Flavonoid Profiles in Pea (Pisum sativum L.) under Cadmium Exposure in Hydroponics: A Study of Metabolomics, Extraction Efficacy, and Antimicrobial Properties of Extracts
PublicationThe current study aimed to investigate the impact of silicon (Si) supplementation in the form of Na2SiO3 on the metabolome of peas under normal conditions and following exposure to cadmium (Cd) stress. Si is known for its ability to enhance stress tolerance in various plant species, including the mitigation of heavy metal toxicity. Cd, a significant contaminant, poses risks to...
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A Green Chemistry "environmentally friendly" approach to the synthesis of chloro-intermediates of ephedrine/pseudoephedrine
PublicationMethylamphetamine is an addictive stimulant drug that strongly activates certain systems in the brain. It is closely related chemically to amphetamine, but the central nervous system effects of methamphetamine are greater. There is much interest in methylamphetamine among scientists and therefore the synthesizes of methylamphetamine and its metabolites are carried out on a large scale in chemical laboratories. Globally, ephedrine...
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A screening of select toxic and essential elements and persistent organic pollutants in the fur of Svalbard reindeer
PublicationReindeers play an important role in the polar ecosystem, being long-lived sole vegetarians feeding on local vegetation. They can be used as a valuable bioindicator, helping us to understand contaminants’ impact on the polar terrestrial ecosystem. Still, scarce data exist from research in which polar herbivores (especially those from the European parts of the Arctic) were a major study subject for trace elements and persistent organic...
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Membrane separation processes for the extraction and purification of steviol glycosides: an overview
PublicationSteviol glycosides (SGs), as natural sweeteners from Stevia rebaudiana, are currently employed for replacing sugar and its derivatives in several food products and formulations. Such compounds play an essential role in human health. Their usage provides a positive effect on preventing diseases related to sugar consumption, including diabetes mellitus, cancer, and lipid metabolism disorders. The traditional extraction of SGs is...
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Recent advancements in LC‐MS based analysis of biotoxins: Present and future challenges
PublicationThere has been a rising concern regarding the harmful impact of biotoxins, source of origin, and the determination of the specific type of toxin. With numerous reports on their extensive spread, biotoxins pose a critical challenge to figure out their parent groups, metabolites, and concentration. In that aspect, liquid chromatography‐mass spectrometry (LC‐MS) based analysis paves the way for its accurate identification and quantification....
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The role of glucuronidation in drug resistance
PublicationThe final therapeutic effect of a drug candidate, which is directed to a specific molecular target strongly depends on its absorption, distribution, metabolism and excretion (ADME). The disruption of at least one element of ADME may result in serious drug resistance. In this work we described the role of one element of this resistance: phase II metabolism with UDP-glucuronosyltransferases (UGTs). UGT function is the transformation...
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Position in global value chains and wages in Central and Eastern European countries
PublicationThis paper examines the relationship between the relative position of industries in Global Value Chains (GVC) and wages in 10 Central and Eastern European countries. We combine GVC measures of global import intensity of production, upstreamness and the length of the value chain with micro-data on workers. We find that the wages of Central and Eastern European countries workers are higher when their industry is at the beginning...
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Selected organophosphorus compounds with biological activity. Applications in medicine
PublicationThe purpose of this article is to provide an overview of the latest applications of organophosphorus compounds (OPs) that exhibit biological activity. A large family of OPs have become popular in recent years. The practical application of OPs in modern medicine has been attributed to their unique properties. In this article, the methods used to select these compounds will be emphasized. This paper will first outline the findings...
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Economic significance of initial public offerings in China and India
PublicationRapid economic growth in China and India has attracted attention of many researchers, focusing on various social and economic factors underlying the success of these countries. One of the key components of country’s economy is financial system which consists of segments such as banking sector and equity market. The topic of initial public offerings (IPOs), one of the corporate financing sources, involving raising funds through...
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The Application of the Thermal Stabilization Prompted by the Ice Cover Expansion Considering the Energy Production Optimization in the Dam-Reservoir Coupled Systems on the Vistula River
PublicationIn this study, the thermal stabilization of a water resource together with an energy production optimization in the power plant of the dam–reservoir coupled system is conducted. This coupled dam system is designed to consist of a primary (Włocławek) and secondary (Siarzewo) dam due to the erosion control aspect. The other beneficial aspect of this coupled dam design is to have an additional power plant, with the aim of achieving...
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Biopolymer-based composites for tissue engineering applications: A basis for future opportunities
PublicationBiomimetic scaffolds supporting tissue regeneration are complex materials with multifunctional characteristics. The unique biocompatibility and biodegradability of biopolymers make them excellent candidates for tissue engineering and regenerative medicine. Biopolymers, which have a wide range of properties, can be obtained from different natural sources. Depending on the target tissue, biopolymers can be engineered to meet a series...