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Wyniki wyszukiwania dla: dengue disease
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Analytical procedures for the determination of fuel combustion products, anti-corrosive compounds, and de-icing compounds in airport runoff water samples
PublikacjaThe purpose of this study is to propose and evaluate new procedures for determination of fuel combustion products, anti-corrosive and de-icing compounds in runoff water samples collected from the airports located in different regions and characterized by different levels of the activity expressed by the number of flights and the number of passengers (per year). The most difficult step in the analytical procedure used for the determination...
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Integration of antifouling properties into epoxy coatings: a review
Publikacjahe need for nontoxic antifouling coatings has encouraged material scientists to develop a class of organic coatings for diverse applications. As a versatile thermosetting resin and well known for coating application, antifouling characteristics have been integrated into epoxy along with anticorrosion and adhesive functions. Accordingly, both micro- and macro-biofoulings have been successfully controlled by using epoxy-based antifouling...
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Molecular dynamics simulations of the affinity of chitin and chitosan for collagen: the effect of pH and the presence of sodium and calcium cations
PublikacjaChitosan and chitin are promising biopolymers used in many areas including biomedical applications, such as tissue engineering and viscosupplementation. Chitosan shares similar properties with hyaluronan, a natural component of synovial fluid, making it a good candidate for joint disease treatment. The structural and energetic consequences of intermolecular interactions are crucial for understanding the biolubrication phenomenon...
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Magnetic nanocomposites for biomedical applications
PublikacjaTissue engineering and regenerative medicine have solved numerous problems related to the repair and regeneration of damaged organs and tissues arising from aging, illnesses, and injuries. Nanotechnology has further aided tissue regeneration science and has provided outstanding opportunities to help disease diagnosis as well as treat damaged tissues. Based on the most recent findings, magnetic nanostructures (MNSs), in particular,...
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Genetic and pharmacologic proteasome augmentation ameliorates Alzheimer’s-like pathology in mouse and fly APP overexpression models
PublikacjaThe proteasome has key roles in neuronal proteostasis, including the removal of misfolded and oxidized proteins, presynaptic protein turnover, and synaptic efficacy and plasticity. Proteasome dysfunction is a prominent feature of Alzheimer’s disease (AD). We show that prevention of proteasome dysfunction by genetic manipulation delays mortality, cell death, and cognitive deficits in fly and cell culture AD models. We developed...
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Abilities, Motivations, and Opportunities of Furloughed Employees in the Context of Covid-19: Preliminary Evidence From the UK
PublikacjaThe Covid-19 global pandemic is a crisis like no other, forcing governments to implement prolonged national lockdowns in an effort to limit the spread of the disease. As organizations aim to adapt and remain operational, employers can suspend or reduce work activity for events related to Covid-19 and claim government support to subsidize employee wages. In this way, some employees are placed on furlough (i.e., temporary unemployment)...
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In silico assessment and sonochemical synthesis of 2-alkynyl 3-chloropyrazines as prospective ligands for SARS-CoV-2
PublikacjaThe recent global pandemic caused by COVID-19 has triggered an intense effort worldwide towards the development of an effective cure for this disease. In our effort we have explored the 2-alkynyl substituted 3-chloropyrazine framework as a potential template for the design of molecules for this purpose. Our strategy was supported by the in silico studies of representative compounds to assess their binding affinities via docking...
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Role of cholesterol in substrate recognition by -secretase
Publikacja-Secretase is an enzyme known to cleave multiple substrates within their transmembrane domains, with the amyloid precursor protein of Alzheimer’s Disease among the most prominent examples. The activity of -secretase strictly depends on the membrane cholesterol content, yet the mechanistic role of cholesterol in the substrate binding and cleavage remains unclear. In this work, we used all-atom molecular dynamics simulations to examine...
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Prevalence Problem in the Set of Quadratic Stochastic Operators Acting on L1
PublikacjaThis paper is devoted to the study of the problem of prevalence in the class of quadratic stochastic operators acting on the L1 space for the uniform topology. We obtain that the set of norm quasi-mixing quadratic stochastic operators is a dense and open set in the topology induced by a very natural metric. This shows the typical long-term behaviour of iterates of quadratic stochastic operators.
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In vitro antioxidant and enzyme inhibitory properties of Rubus caesius L
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Movement perception with the use of a motorized delta armrest and virtual reality
PublikacjaIn this paper we present a combination of neuroscience experiments with the use of a parallel armrest robot to study the effects of temporal delays and spatial biases on the movement perception. A dedicated armrest to guide and manipulate the arm has been developed for these experiments. It is a three-degree-of-freedom Delta structure. In combination with a virtual reality application, the movement perception has been evaluated....
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Pounding between high-rise buildings founded on different soil types
PublikacjaEarthquake-induced pounding is a phenomenon that has been often experienced in previous earthquakes. The aim of this study is to investigate the effect of the soil type on high-rise buildings experiencing earthquake induced-pounding. Pounding between 7-storey and 9-storey buildings is examined under five soil types defined in the ASCE 7-10 code which are hard rock, rock, very dense soil and soft rock, stiff soil and soft clay soil....
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Frakcje fosforu w osadach dennych i ich biodostępność podczas doczyszczania ścieków w systemach ekologicznych
PublikacjaCelem niniejszej pracy było scharakteryzowanie rodzaju i udziału frakcji fosforu w profilu pionowym osadów dennych oraz określenie wpływu zmiany warunków środowiskowych na ich transformację w ekologicznych systemach oczyszczających (w jęz. ang. Ecological Treatment Systems - ETS). W pracy poddano analizie ścieki przepływające przez systemy ekologiczne oraz powstające w procesie oczyszczania osady denne. Badania prowadzono w dwóch...
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Cathepsin G activity lowers plasma LDL and reduces atherosclerosis
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The properties, functions and use of selenium compounds in living organisms
PublikacjaSelenium occurs in the environment in inorganic and organic compounds. For many years it was regarded as a toxic element, causing numerous illnesses and diseases. But research in the last 50 years has revealed a "bright side" to this element, especially as a component of selenoproteins, selenium makes a significant contribution to the health of humans and animals. The selenium content in an organism depends on its concentration...
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A Novel Approach to the Assessment of Cough Incidence
PublikacjaIn this paper we consider the problem of identication of cough events in patients suffering from chronic respiratory diseases. The information about frequency of cough events is necessary to medical treatment. The proposed approach is based on bidirectional processing of a measured vibration signal - cough events are localized by combining the results of forward-time and backward-time analysis. The signal is at rst transformed...
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Fibrillar aggregates in powdered milk
PublikacjaThis research paper addresses the hypothesis that powdered milk may contain amyloid fibrils. Amyloids are fibrillar aggregates of proteins. Up to this time, research on the presence of amyloids in food products are scarce. To check the hypothesis we performed thioflavin T fluorescence assay, X-ray powder diffraction, atomic force microscopy and fluorescence microscopy imaging. Our preliminary results show that commercially available...
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Reducing nighttime light exposure in the urban environment to benefit human health and society
PublikacjaNocturnal light pollution can have profound effects on humans and other organisms. Recent research indicates that nighttime outdoor lighting is increasing rapidly. Evidence from controlled laboratory studies demonstrates that nocturnal light exposure can strain the visual system, disrupt circadian physiology, suppress melatonin secretion, and impair sleep. There is a growing body of work pointing to adverse effects of outdoor lighting...
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Polyether-block-amide PEBA membranes for gas separation and pervaporation; current design and applications
PublikacjaPolyether-block-amide (PEBA) membranes have attracted considerable attention for their exceptional efficacy in gas separation and pervaporation processes. This comprehensive review delves into the precise definition, distinguishing characteristics, and diverse applications of PEBA membranes over the past five years. A primary research objective focuses on enhancing gas separation efficiency, primarily through augmenting membrane...
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Structural, functional, and stability change predictions in human telomerase upon specific point mutations,
PublikacjaOverexpression of telomerase is one of the hallmarks of human cancer. Telomerase is important for maintaining the integrity of the ends of chromosomes, which are called telomeres. A growing number of human disease syndromes are associated with organ failure caused by mutations in telomerase (hTERT or hTR). Mutations in telomerase lead to telomere shortening by decreasing the stability of the telomerase complex, reducing its accumulation,...
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Novel methods for diagnosis of pulmonary microangiopathy in diabetes mellitus
PublikacjaLung microangiopathy is a little known negative influence of diabetes mellitus on the functioning of the lungs. In current medical practice lung microangiopathy is diagnosed by comparing two measurements of lung diffusing capacity - one with the subject standing and one with the subject lying. The necessity to take two measurements is inconvenient. In lung microangiopathy we observe a reduction of diffusing capacity, lung flow...
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Pre-analytical aspects in metabolomics of human biofluids – sample collection, handling, transport, and storage
PublikacjaMetabolomics is the field of omics research that offers valuable insights into the complex composition of biological samples. It has found wide application in clinical diagnostics, disease investigation, therapy prediction, monitoring of treatment efficiency, drug discovery, or in-depth analysis of sample composition. A suitable study design constitutes the fundamental requirements to ensure robust and reliable results from the...
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Context of Digitalized Employment for Older Adults with Autism Spectrum Disorder in the New Normal
PublikacjaEmployers are actively considering how to normalize remote work technology across different industries. The residual risk of coronavirus disease-19 (COVID-19) will necessarily lower the bar for allowing some workers to stay remote on a more permanent basis. This is based on the realization that many essential jobs can be teleworked while retaining or enhancing productivity. The decisions employers make regarding future work arrangements...
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ICT, financial markets and their impact on firms’ performance and internationalisation
PublikacjaThe effects of information and communication technology (ICT) and financial development on growth are highly debated in the literature. Motivated by previous studies and their mixed results, in this study, we propose an analysis to re-examine the ICT-finance puzzle. We go beyond country-specific or sector-specific studies and conduct cross-country analysis with firm-level data. It enables obtaining a broad picture of the ICT-finance-growth...
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Procognitive activity of nitric oxide inhibitors and donors in animal models
PublikacjaNitric oxide is a small gaseous molecule that plays important roles in the majority of biological functions. Impairments of NO-related pathways contribute to the majority of neurological disorders, such as Alzheimer’s disease (AD), and mental disorders, such as schizophrenia. Cognitive decline is one of the most serious impairments accompanying both AD and schizophrenia. In the present study, the activities of NO donors, slow (spermine...
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Mild poikilocapnic hypoxia increases very low frequency haemoglobin oxygenation oscillations in prefrontal cortex
PublikacjaBackground: The aim of the study was to investigate the effect of mild cerebral hypoxia on haemoglobin oxygenation(HbO2), cerebrospinal fluid dynamics and cardiovascular physiology. To achieve this goal, four signals were recorded simultaneously: blood pressure, heart rate / electrocardiogram, HbO2 from right hemisphere and changes of subarachnoid space (SAS) width from left hemisphere. Signals were registered from 30 healthy,...
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Timed rolling and rising tests in Duchenne muscular dystrophy ambulant boys: a feasibility study
PublikacjaBACKGROUND: Functional activities are extensively used in motor assessments of patients with Duchenne muscular dystrophy. The role of timed items has been reported as an early prognostic factor for disease progression. However, there are two functional activities that are not widely assessed in clinical practice among Duchenne muscular dystrophy patients: rolling and bed rising. This study aimed to investigate whether the 360-degree...
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Big Data i 5V – nowe wyzwania w świecie danych (Big Data and 5V – New Challenges in the World of Data)
PublikacjaRodzaje danych, składające się na zbiory typu Big Data, to m.in. dane generowane przez użytkowników portali internetowych, dane opisujące transakcje dokonywane poprzez Internet, dane naukowe (biologiczne, astronomiczne, pomiary fizyczne itp.), dane generowane przez roboty w wyniku automatycznego przeszukiwania przez nie Internetu (Web mining, Web crawling), dane grafowe obrazujące powiązania pomiędzy stronami WWW itd. Zazwyczaj,...
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Consolidating logs in varying formats into a structured repository = konsolidacja logów w zmiennych formatach do strukturalnego repozytorium
PublikacjaDuring multi-agent systems development, testing and re- search, possibly voluminous logs are created at distributed agent loca-tions. These logs describe individual agents behavior and state changes. To get the complete picture of the multi-agent system working, it is necessary to consolidate these logs and to store them in a format appropriate for diverse analyzes. Specic issues arise during consolidation if the log formats are...
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Enzyme-linked carbon nanotubes as biocatalytic tools to degrade and mitigate environmental pollutants
PublikacjaA wide array of organic compounds have been recognized as pollutants of high concern due to their controlled or uncontrolled presence in environmental matrices. The persistent prevalence of diverse organic pollutants, including pharmaceutical compounds, phenolic compounds, synthetic dyes, and other hazardous substances, necessitates robust measures for their practical and sustainable removal from water bodies. Several bioremediation and...
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Physicochemical and Volatile Compounds Analysis of Fruit Wines Fermented with Saccharomyces cerevisiae: FTIR and Microscopy Study with Focus on Anti-Inflammatory Potential
PublikacjaThe growing trend in fruit wine production reflects consumers’ interest in novel, diverse drinking experiences and the increasing demand for healthier beverage options. Fruit wines made from kiwi, pomegranates, and persimmons fermented using S. bayanus Lalvin strain EC1118 demonstrate the versatility of winemaking techniques. Kiwifruit, persimmon, and pomegranate wines were analyzed using HPLC and GC-TOFMS analyses to determine...
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"Walerian Wróbel - Zwei Blicke auf das Unrecht am jungen Zwangsarbeiter"
PublikacjaZur Ausstellung Die tragische Geschichte über das Schicksal des jungen polnischen Zwangsarbeiters Walerian Wróbel (2. April 1925 in Falków — 25. August 1942 in Hamburg) bewegt heute noch viele Menschen. Er wurde im Alter von nur 17 Jahren nach einem Urteil des Sondergerichts Bremen von den Nationalsozialisten hingerichtet. In dieser Ausstellung geht es jedoch nicht um Walerian Wróbel selbst, sondern um den Versuch der...
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Solubility of dapsone in deep eutectic solvents: Experimental analysis, molecular insights and machine learning predictions
PublikacjaBackground. Dapsone (DAP) is an anti-inflammatory and antimicrobial active pharmaceutical ingredient used to treat, e.g., AIDS-related diseases. However, low solubility is a feature hampering its efficient use. Objectives. First, deep eutectic solvents...
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Some variants of perfect graphs related to the matching number, the vertex cover and the weakly connected domination number
PublikacjaGiven two types of graph theoretical parameters ρ and σ, we say that a graph G is (σ, ρ)- perfect if σ(H) = ρ(H) for every non-trivial connected induced subgraph H of G. In this work we characterize (γw, τ )-perfect graphs, (γw, α′)-perfect graphs, and (α′, τ )-perfect graphs, where γw(G), τ (G) and α′(G) denote the weakly connected domination number, the vertex cover number and the matching number of G, respectively. Moreover,...
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Milky Sap of Greater Celandine (Chelidonium majus L.) and Anti-Viral Properties
PublikacjaThe milky juice of the greater celandine herb has been used in folk medicine and in homeopathy for treatment of viral warts for years. However, classical medicine fails to use properties of celandine herbs in treatment of diseases induced by papilloma viruses. Nevertheless, dermatological outpatient clinics are regularly visited by patients reporting efficacy of milky sap isolated from celandine herb in treatment of their own...
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Detection, identification and determination of resveratrol in wine. Problems and challenges
PublikacjaResveratrol is a compound synthesized by plants in response to unfavorable conditions of growth like mechanical injury, siege of bacteria or fungi and UV exposure. It is concentrated mostly in grapes skin and further more in the products made from grapes especially red wines. Each wine is characterized by different amount of given stilbene since its occurrence is affected by many factors like: types of grapes, environment (climate,...
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Indoor air quality in public utility environments-a review
PublikacjaIndoor air quality has been the object of interest for scientists and specialists from the fields of science such as chemistry, medicine and ventilation system design. This results from a considerable number of potential factors, which may influence the quality of the broadly understood indoor air in a negative way. Poor quality of indoor air in various types of public utility buildings may significantly affect an increase in the...
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Inhibition of amyloid fibril formation of hen egg white lysozyme by trimethylamine N-oxide at low pH
PublikacjaIn vitro inhibition of the formation of fibrous aggregates of proteins (amyloids) has gained increasing attention due to the number of diseases associated with protein misfolding and fibrillation. An interesting group of compounds for which pronounced activity against this phenomenon can be expected consists of low molecular weight substances (osmolytes) which have the ability to change protein stability. Here we investigate the...
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Recent advances in aqueous virus removal technologies
PublikacjaThe COVID-19 outbreak has triggered a massive research, but still urgent detection and treatment of this virus seems a public concern. The spread of viruses in aqueous environments underlined efficient virus treatment processes as a hot challenge. This review critically and comprehensively enables identifying and classifying advanced biochemical, membrane-based and disinfection processes for effective treatment of virus-contaminated...
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Assessing the Risk in Urban Public Transport for Epidemiologic Factors
PublikacjaPandemics have presented new challenges for public transport organisers and operators. New diseases (e.g., influenza H1N1, severe acute respiratory syndrome—SARS, as well as, more recently, SARS-CoV-2) increase the need for new protection measures to prevent epidemic outbreaks in public transport infrastructure. The authors’ goal is to present a set of actions in the area of public transport that are adjusted to different levels...
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Evaluation of the Electronic Nose Used for Monitoring Environmental Pollution
PublikacjaAir pollution is a one of the major concern of civilized world, which has a significant impact on human health and the environment. Recent studies highlight that the exposure to polluted air can increase the incidence of diseases and deteriorate the quality of life. Hence, it is necessary to develop tools for real-time air quality monitoring. Electronic-nose systems based on sensors are an interesting and promising technology in...
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Optical method supported by machine learning for dynamics of C‐reactive protein concentrations changes detection in biological matrix samples
PublikacjaIn this article we present the novel spectroscopy method supported with machine learning for real-time detection of infectious agents in wastewater. In the case of infectious diseases, wastewater monitoring can be used to detect the presence of inflammation biomarkers, such as the proposed C-reactive protein, for monitoring inflammatory conditions and mass screening during epidemics for early detection in communities of concern,...
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STRUKTURA SZKŁO-CERAMIKI ZAWIERAJĄCEJ FERROELEKTRYCZNĄ FAZĘ BiV
PublikacjaLiteratura opiusuje próby wytworzenia nanokompozytów, w których skład wchodzą matryca szkła i rozproszone w niej nanokrystality fazy ferroelektrycznej. Najczęstsza metoda wykorzystywana do otrzymywania takiej szkło - ceramiki polega na wytopie szkła, a następnie jego krystalizacji. W literaturze można znaleźć dużo przykładów wytwarzania tego typu materiałów dwu lub więcej składnikowych. Najwięcej badań dotyczy ferroelektrycznych...
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The possibilities of utilization of bottom sediments from fresh water fish farms on the base of legal status of biosludge utilization'
PublikacjaHodowle ryb łososiowatych są źródłem stosunkowo niewielkich ilości odpadów, jakim są osady denne, ale które stanowią istotny problem do rozwiązania dla eksploatatora obiektu. Przepisy prawne generalnie pomijają ten aspekt gospodarki odpadami. właściciele stawów hodowlanych radzą sobie z tymi osadami lepiej lub gorzej, ale przeważnie ich działania ukierunkowane są na tzw. przyrodnicze ich wykorzystanie - najczęściej w granicach...
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Tyre/road noise reduction of poroelastic road surface tested in a laboratory
PublikacjaA so-called poroelastic road surface (PERS) is being developed in Europe. This contains a large percentage of rubber particles mixed with hard aggregate (stone and sand) and bound with polyurethane. This gives high air void content (around 30 %), high elasticity and smooth texture, all of which should give low noise properties. Inthis experiment anominally 30 mm thick sample of PERS was mounted on a steel drum. Various car tyres...
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Modeling emotions for affect-aware applications
PublikacjaThe chapter concerns emotional states representation and modeling for software systems, that deal with human affect. A review of emotion representation models is provided, including discrete, dimensional and componential models. The paper provides also analysis of emotion models used in diverse types of affect-aware applications: games, mood trackers or tutoring systems. The analysis is supported with two design cases. The study...
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Special Issue "Applications of Finite Element Modeling for Mechanical and Mechatronic Systems"
PublikacjaNumerical modeling is very important in today's engineering because, among other things, it reduces the costs associated with prototyping or predicting the occurrence of potentially dangerous situations during operation in certain defined conditions. Different methods have so far been used to implement the real structure into the numerical version. The most popular have been variations of the finite element method (FEM). The aim...
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Technologia utylizacji i gospodarczego wykorzystania osadów ściekowych
PublikacjaOmówiono powstawanie osadów ściekowych w oczyszczalniach ścieków. Podano ilości powstających osadów oraz procesy, jakim są one poddawane. Osady ściekowe posiadają parametry takie jak niski silnie shumifikowany torf albo organiczne osady denne w jeziorach eutroficznych. Osady mogą być wykorzystane do nawożenia gleb albo jako opał. Wskazano na celowość termicznej utylizacji osadów.
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Analytical techniques in studies of the environmental fate of pharmaceuticals and personal-care products
PublikacjaW pracy przedstawiono dane literaturowe odnośnie źródeł emisji, dróg transportu, przemian i metabolizmu, pomiomu stężeń ksenobiotyków z grupy farmaceutyków i środków higieny osobistej w próbkach pobranych z różnych elementów środowiska (woda, gleba, osady denne) oraz próbek bioty. Szczególną uwagę zwrócono na techniki analityczne wykorzystywane w badaniach losu środowiskowego w/w zanieczyszczeń.
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Telomere uncapping by common oxidative guanine lesions: Insights from atomistic models
PublikacjaOxidative damage to DNA is widely known to contribute to aging and disease. This relationship has been extensively studied for telomeres – structures that cap chromosome ends – due to their role in cell proliferation and senescence, and exceptional susceptibility to oxidation. Indeed, the repetitive telomeric DNA sequence contains the 5′-GGG-3′ motif that has the lowest ionization potential of all trinucleotides. Accordingly, experiments...