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Search results for: COMPARATIVE NON-TARGETED LIPIDOMICS
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Analytical Strategies and Applications in Lipidomics
PublicationLipidomics is a field of study aiming at a comprehensive analysis of a set of lipids in biological systems. This includes both quantitative and qualitative characterization of lipid profiles, comparative studies of lipidomes, and analysis of lipid-protein interactions. Lipids are structurally diversified that make their analysis a challenging task. The constant advances in analytical technologies, especially in the field of high-performance...
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Molecular Targets for Anticandidal Chemotherapy
PublicationA relatively small number of anticandidal chemotherapeutics used in clinical practice is at least in part consequence of a limited number of their molecular targets: ergosterol in the membrane, lanosterol demethylase, b(1!3) glucan synthase, and DNA/RNA biosynthesis. Much more potential novel targets have been revealed by the comparative genomic studies identifying essential genes unique for Candida albicans or resulted from recognition...
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Comparative Study on Assisted Solvent Extraction Techniques for the Extraction of Biologically Active Compounds from Sideritis raeseri and Sideritis scardica
PublicationThe plants in the Sideritis genus are postulated to exhibit several important medicinal properties due to their unique chemical composition. To isolate the targeted phytochemical compounds, the selection of a suitable extraction method is of primary importance. In this work, a comparative study on the phytochemical profiles of various Sideritis raeseri and Sideritis scardica extracts has been carried out. An untargeted metabolomics...
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Online Volatile Compound Emissions Analysis Using a Microchamber/Thermal Extractor Coupled to Proton Transfer Reaction-Mass Spectrometry
PublicationIndoor air is a complex and dynamic mixture comprising manifold volatile organic compounds (VOCs) that may cause physiological and/or psychological discomfort, depending on the nature of exposure. This technical note presents a novel approach to analyze VOC emissions by coupling a microchamber/thermal extractor (μ-CTE) system to a proton transfer reaction-mass spectrometer (PTR-MS). This configuration provides an alternative to...
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Voltammetric and biological studies of folate-targeted non-lamellar lipid mesophases
PublicationFolate-targeted lipid nanostructures are promising strategies for the development of biocompatible drug delivery systems. The objective of this study was to evaluate the efficacy of drug delivery to cancer cells by folate-targeted lipid mesophases, cubosomes (CUB) and hexosomes (HEX), loaded with doxorubicin (DOX). Three cancer-derived cell lines (KB, HeLa, T98G) exhibiting different expressional levels of folate receptor protein...
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Comparative Analysis of Salient and Non-Salient Pole Brushless Synchronous Generator for Application in Autonomous Electric Power System
PublicationThis paper presents a comparative study of two types of brushless synchronous generator for application in autonomous electric power systems (e.g. airplane power grid). Commercially used salient pole and a prototype non-salient pole high speed multi-pole brushless synchronous generator (BSG) have been presented. Comparative analysis of both types of the generator has been performed. Chosen simulation (using FEM and circuit models)...
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PLS-Based and Regularization-Based Methods for the Selection of Relevant Variables in Non-targeted Metabolomics Data
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Non-Targeted Metabolite Profiling Reveals Host Metabolomic Reprogramming during the Interaction of Black Pepper with Phytophthora capsici
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Comparative Study of Integer and Non-Integer Order Models of Synchronous Generator
PublicationThis article presents a comparison between integer and non-integer order modelling of a synchronous generator, in the frequency domain as well as in the time domain. The classical integer order model was compared to one containing half -order systems. The half-order systems are represented in a Park d-q axis equivalent circuit as impedances modelled by half-order transmittances. Using a direct method based on the approximation...
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Comparative model tests of SDP and CFA pile groups in non-cohesive soil
PublicationThe research topic relates to the subject of deep foundations supported on continuous flight auger (CFA) piles and screw displacement piles (SDP). The authors have decided to conduct model tests of foundations supported on the group of piles mentioned above and also the tests of the same piles working alone. The tests are ongoing in Geotechnical Laboratory of Gdańsk University of Technology. The description of test procedure, interpretation...
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Igor Szpotakowski
PeoplePrincipal Investigator in the four-year project (2020-2024): “Services contracts in private law of the PRC - codification in the era of decodification” funded by the Polish Ministry of Science and Higher Education “Diamond Grant” programme, which is awarded to the most promising young researchers in Poland. Awarded a Ryoichi Sasakawa Young Leaders Fellowship to conduct one-year research (2020-2021) about “The effects of non-performance...
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Comparative FE-studies of shear localizations in granular bodies within a polar and non-local hypoplasticity.
PublicationW artykule przedstawiono wyniki porównawczej numerycznej analizy lokalizacji odkształceń stycznych w materiałach granulownych przeprowadzonej z nielokalnym i mikropolarnym modelem. Obliczenia wykonano dla ściskania w płaskim stanie odkształcenia stosując metodę elementów skończonych i hipoplastyczne prawo konstytutywne. Analizę przeprowdzonao dla piasku zagęszczonego.
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Soil pH effects on the comparative toxicity of dissolved zinc, non-nano and nano ZnO to the earthwormEisenia fetida
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A Comparative Numerical Simulation Study of Turbulent Non-premixed CO/H2/N2 Syngas Jet Flames
PublicationIn the present work, numerical simulations of turbulent non-premixed syngas flame have been performed in Reynolds-Averaged Naver-Stokes turbulence approach using four turbulence-chemistry interaction models. To this aim, we used assumed beta PDF approach, Steady Laminar Flamelet model, Eddy Dissipation Concept and Partially Stirred Reactor model. Numerical results are compared and analysed with respect to two experiments from the...
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Comparative tests of the wall thickness effect of a glass-reinforced thermosetting plastic coating with a non-circular cross section in a soil-coating object for economic aspect
PublicationCulvert structures made of plastics are employed extensively in the construction of new facilities as well as the renovation of existing ones. Due to the high costs of materials required for the manufacturing of these goods, the objective of this research is focused to lessen the thickness of the walls, which may, on the other hand, result in a reduction in the stiffness of the system. In the course of the testing, the structure...
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Molecularly targeted nanoparticles: an emerging tool for evaluation of expression of the receptor for advanced glycation end products in a murine model of peripheral artery disease
PublicationAbstract Background: Molecular imaging with molecularly targeted probes is a powerful tool for studying the spatio-temporal interactions between complex biological processes. The pivotal role of the receptor for advanced glycation end products (RAGE) in numerous pathological processes, aroused the demand for RAGE targeted imaging in various diseases. In the study, we evaluated the use of a diagnostic imaging agent for RAGE quantification...
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Comprehensive methodology for Staphylococcus aureus lipidomics by liquid chromatography and quadrupole time-of-flight mass spectrometry
PublicationStaphylococcus aureus is a common pathogen known to cause relatively minor infections as well as severe disorders in humans. Although there is fair amount of published data concerning various aspects of its biology, epidemiology, genetics, etc., there is still a scarce amount of data presenting reliable and thorough investigations regarding high-throughput analysis of total S. aureus lipid content. Therefore, the aim of this study...
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Dariusz Mikielewicz prof. dr hab. inż.
PeopleProfessor Dariusz Mikielewicz – born on February 6, 1967. in Gdansk. Here in 1974 he enrolled first to the Elementary School No. 17, and then in the Grammar School No. 5, named after Stefan Żeromski in Gdansk-Oliwa. After graduating from the Secondary School, with honors, in 1985 he successfully passed the entrance exams to the Faculty of Mechanical Engineering of Technical University of Gdansk, where he graduated with a very good...
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The Conference Report of Why R? Turkey 2022: The First R Conference with Call For Papers in Turkey
PublicationWhy R? Turkey 2022 was a non-profit conference that aimed to bring Turkish R users together and encourage them to attend the R conferences. The targeted audience of the conference consisted of, data scientists, data analysts, and all R users from academia and industry. The three-day conference, which consisted of several events such as workshops, regular talks, lightning talks, short tutorials, and panels, was free of charge and...
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TS-based RSM-aided design of cold-formed steel stiffened C-sectional columns susceptible to buckling
PublicationThe paper focuses on joint-performance analysis of a built-up cold-formed thin-walled C-sectional column with a fillister (stiffener) of the same type, interconnected with a series of bolts located along the length of the compressed members in specific spacing. The quantity of bolts and the non-connected starting distance of the fillister are considered random variables of the problem. Optimal distribution of joints on the stiffener...
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Equivalent standard manoeuvres for pod-driven ships
PublicationProcedures for carrying out the manoeuvring tests presented in International Maritime Organisation (IMO) resolution MSC.137(76) are based on the capabilities of ships with conventional steering-propulsion systems. Therefore they do not correspond to ships with other steering-propulsion devices, like pod drives. IMO is aware of this shortcoming and for ships with non-conventional steering and propulsion system may permit the use...
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The use of HPLC-Q-TOF-MS for comprehensive screening of drugs and psychoactive substances in hair samples and several “legal highs” products
PublicationNon-targeted screening of drugs present in herbal products, known as “legal high” drugs and in hair as a biological matrix commonly used in toxicological investigations was accomplished with the use of high pressure liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (HPLC-Q-TOF-MS). In total, 25 and 14 therapeutical drugs and psychoactive substances/metabolites were detected in investigated hair samples...
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E-textbook technologies for academics in medical education
PublicationPublic universities in Poland receive fairly limited financial support for creating e-textbooks and lack the appropriate ICT competences among teaching staff, especially in the case of non-technical universities. The authors propose a pedagogical and technological paradigm for e-textbooks in medical education using open source software with minimal IT skills required. Technologies used to develop e-textbooks are connected with:...
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Effect of Sinusoidal Corrugated Geometries on the Vibrational Response of Viscoelastic Nanoplates
PublicationThe vibrational behavior of viscoelastic nanoplates with a corrugated geometry is a key topic of practical interest. This problem is addressed here for wrinkled nanoplates with small corrugations related to incorrect manufacturing. To this end, a new One-Variable First-order Shear Deformation plate Theory (OVFSDT) is proposed in a combined form with a non-local strain gradient theory. The Kelvin–Voigt model is employed to describe...
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Features of Nonlinear Sound Propagation in Vibrationally Excited Gases
PublicationWeakly nonlinear sound propagation in a gas where molecular vibrational relaxation takes place is studied. New equations which govern the sound in media where the irreversible relaxation may take place are derived and discussed. Their form depends on the regime of excitation of oscillatory degrees of freedom, equilibrium (reversible) or non-equilibrium (irreversible), and on the comparative frequency of the sound in relation to...
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Model tests of cast-in-place piles formed by using different types of auger
PublicationModel tests are still a popular research tool used to observe and determine the mechanisms of pile-soil interaction. Due to the significant scale effect, the results of model tests performed in the 1g system can only be analysed from the qualitative side. This article describes and presents the results of 1g pile model tests carried out for comparative purposes. There were tested the effectiveness and efficiency of various types...
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Influence of Fluid Compressibility and Movements of the Swash Plate Axis of Rotation on the Volumetric Efficiency of Axial Piston Pumps
PublicationThis paper describes the design of a swash plate axial piston pump and the theoretical models describing the bulk modulus of aerated and non-aerated fluids. The dead space volume is defined and the influence of this volume and the fluid compressibility on the volumetric efficiency of the pump is considered. A displacement of the swash plate rotation axis is proposed to reduce the dead space volume for small swash plate swing angles....
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Precise Bathymetry as a Step Towards Producing Bathymetric Electronic Navigational Charts for Comparative (Terrain Reference) Navigation
PublicationBathymetric Electronic Navigational Charts (bENCs) contain only bathymetry data and can be used in applications such as underwater positioning, dredging and piloting. According to International Hydrographic Organization (IHO) standard S-57, Electronic Navigational Charts (ENCs) contain depth information with pure density of depth contours. Typical depth contours encoded by Hydrographic Offices are limited to 2, 5, 10 and 20 m....
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Assessment of Connectivity-based Resilience to Attacks Against Multiple Nodes in SDNs
PublicationIn Software Defined Networks (SDNs), the control plane of a network is decoupled from its data plane. For scalability and robustness, the logically centralized control plane is implemented by physically placing different controllers throughout the network. The determination of the number and placement of controllers is known as the Controller Placement Problem (CPP). In the regular (i.e., failure-free) state, the control plane...
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The mechanism of grouting action under the base of bored pile
PublicationThe grouting under the base of bored pile is carried out in order to reduce pile settlement and improve its bearing capacity. The principal aim of grouting is to introduce an initial force between the soil and the pile base. In non-cohesive soil, the grouting can also enlarge the pile base area and therefore improve the base resistance. The example of static load tests on instrumented bored piles installed with and without grouting...
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Gigantic electro-chemo-mechanical properties of nanostructured praseodymium doped ceria
PublicationSome oxygen defective fluorites are non-Newnham electrostrictors, i.e., the electromechanical response does not depend on their dielectric properties. Here, we show gigantic electrostriction in nanocrystalline 25 mol% praseodymium doped ceria (PCO) bulk ceramics. The material was fabricated with a fieldassisted spark plasma sintering (SPS) process from high-purity nanoscale PCO powders (<20 nm). The SPS process consolidates the...
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Utilization of a Non-Linear Error Function in a Positioning Algorithm for Distance Measurement Systems Designed for Indoor Environments
PublicationA new positioning algorithm for distance measurement systems is outlined herein. This algorithm utilizes a non-linear error function which allows us to improve the positioning accuracy in highly difficult indoor environments. The non-linear error function also allows us to adjust the performance of the algorithm to the particular environmental conditions. The well-known positioning algorithms have limitations, mentioned by their...
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Extended investigation of performance-energy trade-offs under power capping in HPC environments
Publication—In the paper we present investigation of performance-energy trade-offs under power capping using modern processors. The results are presented for systems targeted at both server and client markets and were collected from Intel Xeon E5 and Intel Xeon Phi server processors as well as from desktop and mobile Intel Core i7 processors. The results, when using power capping, show that we can find various interesting combinations of...
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Comparative analysis of mRNA transcripts of HT-29 cell line expressed in identical quantities for pathogenic E. coli strains UM146 and UM147 with control Escherichia coli Nissle 1917
PublicationAim of study was comparative analysis of mRNA transcripts of HT-29 cell line, expressed in identical quantities for the combination of pathogenic and non-pathogenic Escherichia coli strains. HT-29 confluent monolayers infection with two pathogenic E. coli strains UM146 and UM147 resulted in two sets of mRNA transcripts that were identical with RNA transcripts obtained for non-pathogenic one strain E. coli Nissle 1917. In this study...
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Rotor flux and EEMF observer for interior permanent magnet synchronous machine
PublicationIn recent years, the use of the interior permanent magnet synchronous machine (IPMSM) in various applications has grown significantly due to numerous benefits. Sensors are used to achieve high efficiency and good dynamic response in IPMSM drives but due to their high cost and reduced overall size of the system, sensorless control techniques are preferred. Non-sinusoidal distribution of rotor flux and slot harmonics are present...
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Synthesis, Chemical Characterization and Multiscale Biological Evaluation of a dimericcRGD Peptide for Targeted Imaging of αVβ3 Integrin Activity
PublicationCyclic peptides containing the Arg-Gly-Asp (RGD) sequence have been shown to specifically bind the angiogenesis biomarker α V β3 integrin. We report the synthesis, chemical characterization, and biological evaluation of two novel dimeric cyclic RGD-based molecular probes for the targeted imaging of α V β3 activity (a radiolabeled version, 64Cu-NOTA-PEG4-cRGD2, for PET imaging, and a fluorescent version, FITC-PEG4-cRGD2, for in...
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Methodology for Processing of 3D Multibeam Sonar Big Data for Comparative Navigation
PublicationAutonomous navigation is an important task for unmanned vehicles operating both on the surface and underwater. A sophisticated solution for autonomous non-global navigational satellite system navigation is comparative (terrain reference) navigation. We present a method for fast processing of 3D multibeam sonar data to make depth area comparable with depth areas from bathymetric electronic navigational charts as source maps during...
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Sustainable energy system combined biogas-feedSolid Oxide Fuel Cell and Microalgae technology
PublicationIn the new frontier of energy and environmental safety, new efficient and clean safe energy conversion systems are required. In this sense, the present work is framed within the context of Circular Economy and proposes a multidisciplinary study for the development of more efficient, economically viable and non-polluting energy conversion systems, based on the synergetic combination of different technologies: fuel cells, biofuels,...
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Deterioration of masonry structure investigated by a thermal camera with a qualitative assessment of thermal image processing
PublicationThermal imaging is contemporary remote sensing measurement technique, which provides an image of the temperature distribution in the measured object. The method is widely used, due to its mobility as well as the non-destructive character of the measurement. Infrared thermography is especially relevant in the inspection of insulation, what is more, it is a suitable device for detecting thermal bridges and structural changes, which...
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Implementation of Non-Probabilistic Methods for Stability Analysis of Nonlocal Beam with Structural Uncertainties
PublicationIn this study, a non-probabilistic approach based Navier’s Method (NM) and Galerkin Weighted Residual Method (GWRM) in term of double parametric form has been proposed to investigate the buckling behavior of Euler-Bernoulli nonlocal beam under the framework of the Eringen's nonlocal elasticity theory, considering the structural parameters as imprecise or uncertain. The uncertainties in Young’s modulus and diameter of the beam are...
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Stable nanoconjugates of transferrin with alloyed quaternary nanocrystals Ag–In–Zn–S as a biological entity for tumor recognition
PublicationOne way to limit the negative effects of anti-tumor drugs on healthy cells is targeted therapy employing functionalized drug carriers. Here we present a biocompatible and stable nanoconjugate of transferrin anchored to Ag-In-Zn-S quantum dots modified with 11-mercaptoundecanoic acid (Tf-QD) as a drug carrier versus typical anticancer drug, doxorubicin. Detailed investigations of Tf-QD nanoconjugates without and with doxorubicin...
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Comparative review of piezoelectric biomaterials approach for bone tissue engineering
PublicationBone as a minerals’ reservoir and rigid tissue of the body generating red and white blood cells supports various organs. Although the self-regeneration property of bone, it cannot regenerate spontaneously in severe damages and still remains as a challenging issue. Tissue engineering offers several techniques for regenerating damaged bones, where various biomaterials are examined to fabricate scaffolds for bone repair. Piezoelectric...
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Sensitive Demonstration of the Twin-Core Couplers including Kerr Law Non-Linearity via Beta Derivative Evolution
PublicationTo obtain new solitary wave solutions for non-linear directional couplers using optical meta-materials, a new extended direct algebraic technique (EDAT) is used. This model investigates solitary wave propagation inside a fiber. As a result, twin couplers are the subject of this study. Kerr law is the sort of non-linearity addressed there. Because it offers solutions to problems with large tails or infinite fluctuations, the resulting...
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Study of the formation of calcareous deposits on cathodically protected steel in Baltic sea water
PublicationPurpose – The purpose of this paper is to investigate whether the sedimentation of calcareous deposits occurs on cathodically protected steel in Baltic sea water. Design/methodology/approach – Steel electrodes were cathodically polarized in natural Baltic sea water at potential þ0.150 V vs Zn electrode in potentiostatic mode. During exposure chronoamperometric measurements were carried out. After the exposure, the electrode’s surface...
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Aptamer based tools for environmental and therapeutic monitoring: A review of developments, applications, future perspectives
PublicationNucleic acids in the form of aptamers play a growing and significant role in the targeted and rapid analysis of environmental sample composition and medical analyses. In this paper, the review of both aptamers synthesis methods as well as application of these short chain oligonucleotides (with critical comments on their strong and weak features) are given. The first ones include: systematic evolution of ligands by exponential enrichment...
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Thematic Areas in the Polish Countryside and Their Role in Local Development
PublicationThe article defines the phenomenon of space thematisation with regards to rural areas in Poland. The typology of thematic spaces and criteria of their comparative description have been proposed. Thematic villages, home gardens, amusement parks and housing estates have been distinguished. They have been compared in terms of spatial availability, the degree of user participation and the commercial vs. non-commercial creation purpose....
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THE CONCEPT AND THE STATE OF RESEARCH ON THE PERFORMANCE OF FAMILY BUSINESSES
PublicationPurpose: This study's primary goal is to present the theoretical concept of family enterprises. Specifically, the results of earlier studies and the issues facing this field of research now will be described. The article also examines the underlying impacts that family control has on business management in order to fill the research gap left by earlier studies on the performance differences between family and non-family enterprises....
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Foliate-Targeting Quantum Dots-β-Cyclodextrin Nanocarrier for Efficient Delivery of Unsymmetrical Bisacridines to Lung and Prostate Cancer Cells
PublicationTargeted drug delivery by nanocarriers molecules can increase the efficiency of cancer treatment. One of the targeting ligands is folic acid (FA), which has a high affinity for the folic acid receptors, which are overexpressed in many cancers. Herein, we describe the preparation of the nanoconjugates containing quantum dots (QDs) and β-cyclodextrin (β-CD) with foliate-targeting properties for the delivery of anticancer compound...
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Sensing Direction of Human Motion Using Single-Input-Single-Output (SISO) Channel Model and Neural Networks
PublicationObject detection Through-the-Walls enables localization and identification of hidden objects behind the walls. While numerous studies have exploited Channel State Information of Multiple Input Multiple Output (MIMO) WiFi and radar devices in association with Artificial Intelligence based algorithms (AI) to detect and localize objects behind walls, this study proposes a novel non-invasive Through-the-Walls human motion direction...
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Comparative analysis of earthships and conventional buildings in terms of investment and operating costs
PublicationThe aim of the master's thesis is to present the idea of earthships and compare them with conventional buildings in terms of investment and operating costs. Earthships are buildings erected from tires and other wastes whose characteristic feature is their self-sufficiency. The first part of the master's thesis is to discuss the basic issues related to the earthship building. The beginnings of tire homes and their development are...