Search results for: alkyne
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DETECTION OF BREATHING AND HEART RATE USING AN ECG SIGNAL MEASURED WHILE BATHING IN THE BATHTUB
PublicationNowadays a new area of interest is gaining importance - it is home biomedical examination. Intelligent home can be supported by set of devices for habitants observation. It can be particularly useful for elders or person with some health risks but living alone. One of critical locations within the house is bathroom. One of utilities in the bathroom is a bathtub which is sometimes preferred over shower. There are reports of problems...
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Synthesis of malonylenamides and thiomalonylenamides
Publication5-[Hydroksyl(aryl(amino))methylene]-2,2-dimethyl-1,3-dioxane-4,6-dione is convenient source of ketenes which can be trapped with various nucleophiles like alcohols, thiols and amines. In reaction between in situ generated ketene and enolizable imines we can easily obtain corresponding malonylenamides. This facile method can be used to obtain thiomalonylenamides using 5-[sulfhydrylo(alkyl(amino))methylene]-2,2-dimethyl-1,3-dioxane-4,6-dione...
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Degradation of Polycaptolactone Modified with TPS or CaCO3 in Biotic/Abiotic Sewater
PublicationThe polymer degradation process in two types of water sourced from the Baltic Sea was investigated. Polycaprolactone modified with thermoplastic starch(PCL/TPS>85%) or calcium carbonate (60% PCL/40% CaCO3)and PCL alone were incubated for 28 weeks in sea water with and without microrganisms. The experimental results indicated that in each of the experiments degradation occured. The process was more effective in sea water with microorganisms.Modification...
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Efficient Synthesis of Functionalized Unsymmetrical Dialkyl Trisulfanes
PublicationWe have developed a convenient method for the synthesis of functionalized unsymmetrical dialkyl trisulfanes under mild conditions in very good yields. The designed method is based on the reaction of (5,5-dimethyl-2-thioxo-1,3,2-dioxaphosphorinan-2-yl)-disulfanyl derivatives with alkyl disulfanyl anions generated in situ from S-acetyl disulfanyl derivatives and sodium methoxide. The developed method allows for the preparation of...
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An efficient and convenient synthesis of unsymmetrical disulfides from thioacetates
PublicationWe have developed convenient methods for the synthesis of functionalized unsymmetrical dialkyl disulfides under mild conditions in very good yields. The designed method is based on the reaction of (5,5-dimethyl-2-thioxo-1,3,2-dioxaphosphorinan-2-yl)-disulfanyl derivatives 1 with functionalized alkyl thiolate anions, generated in situ from thioacetates2and sodium methoxide or butylamine. The developed method allows the preparation...
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Inhibition of impurities formation in the synthesis of N-alkyltheobromines stimulated by microwave irradiation. Cationic and anionic response of membrane electrodes
PublicationN-Alkyltheobromine (1-9) derivatives were obtained by reacting theobromine with appropriate alkyl halide under microwave irradiation at 100-150 W and by conventional synthesis. Formation of by-products of oxygen atom alkylation and 1-N-alkyltheobromine ring opening were considered. The presented compounds 1-5 have been studied as ion carriers in ion-selective membrane electrodes. Selectivity of these membranes was studied towards...
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Artificial Neural Network in Forecasting the Churn Phenomena Among Costumers of IT and Power Supply Services
PublicationThis paper presents an attempt to use an artificial neural network to investigate the churn phenomenon among the customers of a telecommunications operator. An attempt was made to create a data model based on the customer lifetime value (CLV) rather than on activity alone. A multilayered artificial neural network was used for the experiments. The results yielded a 99% successful identification rate for customers in no danger of...
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Opracowanie dogodnej metody tworzenia wiązań S-C o hybrydyzacji atomu węgla sp oraz sp2
PublicationBadania przeprowadzone w Katedrze Chemii Organicznej Wydziału Chemicznego Politechniki Gdańskiej na przestrzeni ostatnich kilku lat, pokazały wszechstronność pochodnych kwasu neopentylidenofosforoditiowego. Dotychczasowe wyniki badań doprowadziły mnie do opracowania nowych strategii syntetycznych, umożliwiających otrzymywanie związków zawierających wiązanie C-S o hybrydyzacji atomu węgla sp oraz sp2. Analizując wyniki badań opracowałam...
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Improved cytotoxicity and preserved level of cell death induced in colon cancer cells by doxorubicin after its conjugation with iron-oxide magnetic nanoparticles
PublicationA promising strategy for overcoming the problem of limited efficacy in antitumor drug delivery and in drug release is the use of a nanoparticle-conjugated drug. Doxorubicin (Dox) anticancer chemotherapeutics has been widely studied in this respect, because of severe cardiotoxic side effects. Here, we investigated the cytotoxic effects, the uptake process, the changes in cell cycle progression and the cell death processes in the...
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Evaluation of electrosynthesized reduced graphene oxide–Ni/Fe/Co-based (oxy)hydroxide catalysts towards the oxygen evolution reaction
PublicationIn this work, the specific role of the addition of graphene oxide (GO) to state-of-the-art nickel–iron (NiFe) and cobalt–nickel–iron (CoNiFe) mixed oxides/hydroxides towards the oxygen evolution reaction (OER) is investigated. Morphology, structure, and OER catalytic activity of the catalysts with and without GO were studied. The catalysts were fabricated via a two-step electrodeposition. The first step included the deposition...
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Detection of person presence and its activity in the bathtub
PublicationA practical application of a bioimpedance technique for a detection of a bathing person is presented in the paper. It addresses the possibility of supervising people in the bathtub without voiding of their intimacy. The measurement system installed in a fiber-glass or a plastic bathtub is able to detect a presence of the bathing person, to estimate its activity and thus to detect potentially dangerous events. In the paper a principle...
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Thermodynamic interpretation and prediction of CO2 solubility in imidazolium ionic liquids based on regular solution theory
PublicationRegular solution theory (RST) is the most popular model for the interpretation of the interaction between CO2 and ionic liquids. In the present work, the parameters of this model were determined for the CO2 absorption in eleven imidazolium ionic liquids. The y-intercept (A) of the RST model for the investigated imidazolium liquids increases with increasing temperature whereas the slope (B) remains constant. The values of RST parameters...
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Unconditionally blue: Curing epoxy with polyethylene glycol (PEG) surface-functionalized Zn Fe3-O4 magnetic nanoparticles
PublicationNanoparticles govern early (chemical-controlled) and late (diffusion-controlled) stages of epoxy crosslinking, respectively. Surface functionalization of nanoparticles with macromolecules was recognized as an effective route to compensate for inadequate diffusion-controlled crosslinking. However, the effect of bulk composition amended with cations having catalytic effect towards epoxy ring opening has remained hitherto undescribed....
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Quantum Dots as a Good Carriers of Unsymmetrical Bisacridines for Modulating Cellular Uptake and the Biological Response in Lung and Colon Cancer Cells
PublicationNanotechnology-based drug delivery provides a promising area for improving the efficacy of cancer treatments. Therefore, we investigate the potential of using quantum dots (QDs) as drug carriers for antitumor unsymmetrical bisacridine derivatives (UAs) to cancer cells. We examine the influence of QD–UA hybrids on the cellular uptake, internalization (Confocal Laser Scanning Microscope), and the biological response (flow cytometry...
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Antioxidant properties of ferrous flavanol mixtures
PublicationInteraction of metal, especially iron ions with flavanols is considered as an important feature of these compounds and is believed to contribute to their both antioxidant and prooxidant properties. The aim of this study was to examine how Fe2+ binding to form a 4:1 (flavanol:Fe2+) mixtures affects the antioxidant properties of flavanols. ABTS∗ scavenging, protection against fluorescence bleaching induced by AAPH and hypochlorite,...
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Synthesis and biological activity of ester derivatives of mycophenolic acid and acridines/acridones as potential immunosuppressive agents
PublicationImproved derivatives of mycophenolic acid (MPA) are necessary to reduce the frequency of adverse effects, this drug exerts in treated patients. In this study, MPA was coupled with N-(x-hydroxyalkyl)-9-acridone-4-carboxamides or N-(x-hydroxyalkyl)acridine-4-carboxamides to give respective ester conjugates upon Yamaguchi protocol. This esterification required protection of phenol group in MPA. Designed conjugates revealed higher...
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Two complementary approaches for the synthesis and isolation of stable phosphanylphosphaalkenes
PublicationPhospha-Wittig (phosphanylphosphinidene titanium(IV) complex) and phospha-Peterson (lithiated diphosphane) reactions were used to obtain phosphanylphosphaalkenes with the general formula XYC=P-PtBu2 (X = alkyl, aryl group or H; Y = alkyl or aryl group). Therefore, two series of reactions with different ketones and aldehydes were performed. An examination revealed that the two methods are complementary. For smaller carbonyl compounds,...
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First deep eutectic solvent-based (DES) stationary phase for gas chromatography and future perspectives for DES application in separation techniques
PublicationThe paper presents the first application of deep eutectic solvents (DES) as stationary phases for gas chromatography. DES obtained by mixing tetrabutylammonium chloride (TBAC) as a hydrogen bond acceptor (HBA) with heptadecanoic acid being a hydrogen bond donor (HBD) in a mole ratio of HBA:HBD equal to 1:2 was characterized by its ability to separate volatile organic compounds (VOCs). The Rohrschneider – McReynolds constants determined...
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Smart Modeling of Maritime Vessels
PublicationCurrently, the market offers many visualization tools available to graphic designers, engineers, managers and academics working on maritime environments. The practice of visualization involves making and manipulating images that convey novel phenomena and ideas. Visual communication, together with virtual reality environments, is an emerging and rapidly evolving discipline. It brings great advantage over written word or voice alone,...
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Facing the brainstorming theory. A case of requirements elicitation
PublicationKnowledge is still considered to be power and its externalization makes it possible for others to use that power. In this paper, we examine the theory of brainstorming, and the claim by father Alex Osborn that in a group session an individual can think of twice as many ideas than working alone. In the context of requirements elicitation, we performed an experiment on a “nominal” and a “real” group of participants, following a procedure...
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Human Centric Lighting. The New X Factor?
PublicationWe live in challenging times, and one could even claim we’re experiencing a revolution in lighting with LED technology taking over the world. Part of this rapid change involves a concept called Human Centric Lighting (HCL). In Frankfurt this year, during Light+Building, it was the buzzword, with nearly every second manufacturer’s stand claiming they had figured out the special formula necessary to create perfect HCL illumination....
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Assessment of Electronic Sensing Techniques for the Rapid Identification of Alveolar Echinococcosis through Exhaled Breath Analysis
PublicationHere we present a proof-of-concept study showing the potential of a chemical gas sensors system to identify the patients with alveolar echinococcosis disease through exhaled breath analysis. The sensors system employed comprised an array of three commercial gas sensors and a custom gas sensor based on WO3 nanowires doped with gold nanoparticles, optimized for the measurement of common breath volatile organic compounds. The measurement...
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Synergistic effect of multi walled carbon nanotubes and reduced graphene oxides in natural rubber for sensing application
PublicationUtilizing the electrical properties of polymer nanocomposites is an important strategy to develop high performance solvent sensors. Here we report the synergistic effect of multi walled carbon nanotubes (MWCNTs) and reduced graphene oxide (RGO) in regulating the sensitivity of the naturally occurring elastomer, natural rubber (NR). Composites were fabricated by dispersing CNTs alone and together with exfoliated RGO sheets (thermally...
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Revealing the Frank–Evans “Iceberg” Structures within the Solvation Layer around Hydrophobic Solutes
PublicationUsing computer simulations, the structural properties of solvation water of three model hydrophobic molecules, methane and two fullerenes (C60 and C80), were studied. Systems were simulated at temperatures in the range of 250−298 K. By analyzing both the local ordering of the molecules of water in the solvation layers and the structure of hydrogen bond network, it is shown that in the solvation layer of hydrophobic molecules, ordered...
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Neural Network Subgraphs Correlation with Trained Model Accuracy
PublicationNeural Architecture Search (NAS) is a computationally demanding process of finding optimal neural network architecture for a given task. Conceptually, NAS comprises applying a search strategy on a predefined search space accompanied by a performance evaluation method. The design of search space alone is expected to substantially impact NAS efficiency. We consider neural networks as graphs and find a correlation between the presence...
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Increased cytotoxicity of an unusual DNA topoisomerase II inhibitor compound C-1305 toward HeLa cells with downregulated PARP-1 activity results from re-activation of the p53 pathway and modulation of mitotic checkpoints
PublicationOur previous studies have shown that murine fibroblast cells, in which PARP-1 gene was inactivated by gene disruption, are extremely sensitive to triazoloacridone compound C-1305, an inhibitor of DNA topoisomerase II with unusual properties. Here, we show that pharmacological inhibition of PARP-1 activity by its inhibitor compound NU1025, sensitizes human cervical carcinoma HeLa cells to compound C-1305 compared to treatment with...
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Selected anionic and cationic surface active agents: case study on the Kłodnica sediments
PublicationSurface active agents (surfactants) are a group of chemical compounds, which are used as ingredients of detergents, cleaning products, cosmetics and functional products. After use, wastes containing surfactants or their degradation products are discharged to wastewater treatment plants or directly into surface waters. Due to their specific properties of SAAs, compounds are able to migrate between different environmental compartments...
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Between therapy effect and false-positive result in animal experimentation
PublicationDespite the animal models’ complexity, researchers tend to reduce the number of animals in experiments for expenses and ethical concerns. This tendency makes the risk of false-positive results, as statistical significance, the primary criterion to validate findings, often fails if testing small samples. This study aims to highlight such risks using an example from experimental regenerative therapy and propose a machine-learning...
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Desulfurization of raw naphtha cuts using hybrid systems based on acoustic cavitation and advanced oxidation processes (AOPs)
PublicationA combination of dual-frequency acoustic cavitation (acoustic cavitation) and UV assisted advanced oxidation processes (AOPs) reaction system was developed for desulfurization of raw naphtha used to produce aviation fuels. Various types of oxidants in hybrid systems including hydrogen peroxide, acetic acid, acetone, air and ozone were compared. At optimum oxidant to sulfur compounds molar ratio (rox) of 5.0, the hybrid process...
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Integration of inertial sensors and GPS system data for underwater navigation
PublicationThe Inertial Navigation System (INS) is usually employed to determine the position of an underwater vehicles, like Remotely Operated Vehicles (ROV) and, more recently, Autonomous Underwater Vehicle (AUV). The accuracy of the position provided by the INS, which uses accelerometers and gyroscopes, deteriorates with time. An external aiding sources such as the Global Positioning System (GPS) can be employed to reduce the error growth...
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Structural Factors Affecting Cytotoxic Activity of (E)-1-(Benzo[d ][1,3]oxathiol-6-yl)-3-phenylprop-2-en-1-one Derivatives
PublicationDerivatives of (E)-1-(5-alkoxybenzo[d][1,3]oxathiol-6-yl)-3-phenylprop-2-en-1-one (1) demonstrated exceptionally high in vitro cytotoxic activity, with IC50 values of the most active derivatives in the nanomolar range. To identify structural fragments necessary for the activity, several analogs deprived of selected fragments were prepared, and their cytotoxic activity was tested. It was found that the activity depends on combined effects...
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Novel Polyurethanes as Antifouling Paint Matrices
PublicationThe new poly(ester-ether urethane)s (PEEUR) were prepared in two stage synthesis from formerly obtained oligo(alkylene ester-ether)diols (OAEE) and 4,4‘-diphenylmethane diisocyanate (MDI). PEEUR samples were subjected to crosslinking with styrene in the presence of radical polymerization initiators: methyl ethyl ketone peroxide (MEKPO) or cobalt 2-ethyl cyclohexanoate (EtHCo). Crosslinked PEEUR were characterized by their physicochemical...
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Measurement of activity coefficients at infinite dilution of organic solutes in the ionic liquid 1-hexyl-1,4-diaza[2.2.2]bicyclooctanium bis(trifluoromethylsulfonyl)imide using gas–liquid chromatography
PublicationBased on gas–liquid chromatography (GLC) retention data, activity coefficients at infinite dilution of 39 different solutes in the ionic liquid 1-hexyl-1,4-diaza[2.2.2]bicyclooctanium bis(trifluoromethylsulfonyl)imide ([HDABCO][NTf2]) have been determined. Measurements covered a broad range of types of organic solutes including alkanes, alcohols, ketones, benzene derivatives and McReynold’s compounds. Activity coefficients were...
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Evolutionary sets of safe ship trajectories with speed reduction manoeuvres within traffic separation schemes
PublicationIn the previous paper the author presented the evolutionary ship trajectory planning method designed to support Traffic Separation Schemes (TSS). This time the extensions of this method are described which allow to combine evolutionary trajectory planning with speed reduction manoeuvres. On TSS regions with higher than usual density of traffic and smaller distances between ships, the course alterations alone are not always sufficient...
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Experimental research on a hydrodynamic thrust bearing with hydrostatic lift pockets: Influence of lubrication modes on bearing performance
PublicationThe aim of the study is to investigate the performance of a thrust bearing equipped with hydrostatic lift pockets under different lubrication modes. Three types of flat land bearing lubrication modes are studied experimentally: hydrostatic lubrication (HS; forced oil injection to the pockets), hybrid lubrication (HS + HD; hydrostatic lubrication combined with the external forced bearing oil supply) and hydrodynamic lubrication...
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Problematyka dotycząca zapewnienia fotostabilności substancji leczniczych w postaciach leku
PublicationUV and visible radiation may influence on the stability of some active pharmaceutical ingredients and in a consequence destabilizes such medicinal products, causes changesin its physicochemical properties also with negative pharmacological and sometimes even toxic effects. For this reason it is important to conduct the routine testing photostability. The knowledge of chemistry and technology as well as some methods of...
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Interaction of Novel Ionic Liquids with Soils
PublicationWith the constant development of new ionic liquids, the understanding of the chemical fate of these compounds also needs to be updated. To this effect, in this contribution, the interaction of a number of novel ionic liquids with soils was determined. Therefore, three novel headgroups (ammonium, phosphonium or pyrrolidinium) with single or quaternary substitution were tested on a variety of soils with high to low organic matter...
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Anticarcinogenic and antioxidant activities of leaves and flowers hydroalcoholic extracts of Nerium oleander L.: PCA analysis and phytochemical content by FTIR spectroscopy
PublicationAims: The aim of this work is the evaluation the anticarcinogenic effect on HT29 cancer cells lines and antioxidant effect of three extracts from different morphological parts (leaves (LE), pink flowers (PFE) and white flowers (WFE)) of Nerium oleander lin. Methods: This research provides the anticarcinogenic activity of extracts from N. oleander white flowers. Principal Component Analysis (PCA) was applied to estimate the relationship...
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Trustworthy Applications of ML Algorithms in Medicine - Discussion and Preliminary Results for a Problem of Small Vessels Disease Diagnosis.
PublicationML algorithms are very effective tools for medical data analyzing, especially at image recognition. Although they cannot be considered as a stand-alone diagnostic tool, because it is a black-box, it can certainly be a medical support that minimize negative effect of human-factors. In high-risk domains, not only the correct diagnosis is important, but also the reasoning behind it. Therefore, it is important to focus on trustworthiness...
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Risks caused by microbiologically influenced corrosion in diesel fuel storage tanks
PublicationMicrobiologically influenced corrosion (MIC) poses serious problems for the petrochemical and refinery industries. Particularly favourable conditions for MIC arise in storage tanks and transmission pipelines for mixtures of diesel oil with the addition of a biocomponent (in Poland 7%). The best conditions for the development of MIC occur at the fuel-water interface, where microorganisms are provided with a source of food and water,...
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Thickness and structure change of titanium (IV) oxide thin films synthesized by the sol–gel spin coating method
PublicationTitanium dioxide is a well-known material in nanotechnology, while it provides new opportunities due to its interesting properties, for example, as a semiconductor with a quite significant forbidden band gap energy of 3.2 eV. In this study, thin films of titanium dioxide (TiO2) were synthesized in amorphous and crystallographic systems using the sol–gel process. Atomic Force Microscopy (AFM), Raman spectroscopy and X-ray diffraction...
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Atom-economic thiophosphoroselenenylations of C–H acid esters and amides
PublicationThree improved thiophosphoroselenenylation procedures of CHacids, including derivatives of malonic and acetyl-, phosphono-, 4-nitrophenyl- and 3-pyridylacetic acids, have been described and compared to previously reported thiophosphoroselenylation of diethyl malonate using bis(disopropoxyphosphinothioyl)diselenide alone or with the aid of methyl iodide. The use of iodine makes it possible to utilize both equivalents of the selenenylating...
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X-ray and UV Radiation Damage of dsDNA/Protein Complexes
PublicationRadiation and photodynamic therapies are used for cancer treatment by targeting DNA. However, efficiency is limited due to physico-chemical processes and the insensitivity of native nucleobases to damage. Thus, incorporation of radio- and photosensitizers into these therapies should increase both efficacy and the yield of DNA damage. To date, studies of sensitization processes have been performed on simple model systems, e.g.,...
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Filozofować z głębi człowieczeństwa. O fenomenologii Andrzeja Półtawskiego.
PublicationDokonując krytyki tradycji nowożytnego empiryzmu i kartezjańskiego dualizmu Półtawski tworzy realistyczną i dynamiczną interpretację bytu ludzkiego. Przeżywanie, odczuwanie zmysłowe nie jest poślednią odmianą poznania jak i operacją dostarczania jedynie elementów, budulca poznaniu, ale odrębnym sposobem bycia w świecie, jest symbiotycznym kontaktem z otoczeniem, formą życia. Zrywa on radykalnie z tradycją brentanowsko-husserlowską...
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DETERMINATION OF SURFACTANTS IN ENVIRONMENTAL SAMPLES. PART II. ANIONIC COMPOUNDS
PublicationSurfactants (SAA) with negative charge of polar group are named as anionic compounds. They are main constituent of most products containing synthetic surfactants. The linear alkylbenzene sulfonates (LAS), alkyl ethoxysulfates (AES) and alkyl sulfates (AS) are typically applied from this class of compounds. Those surfactants are ingredients of household detergents and cleaners, laundry detergents, cosmetic. Moreover they can be...
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Hypericum alpestre extract exhibits in vitro and in vivo anticancer properties by regulating the cellular antioxidant system and metabolic pathway of L‐arginine
PublicationConventional treatment methods are not effective enough to fight the rapid increase in cancer cases. The interest is increasing in the investigation of herbal sources for the development of new anticancer therapeutics. This study aims to investigate the antitumor capacity of Hypericum alpestre (H. alpestre) extract in vitro and in vivo, either alone or in combination with the inhibitors of the L‐arginine/polyamine/nitric oxide...
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Understanding ion–ion and ion–solvent interactions in aqueous solutions of morpholinium ionic liquids with N-acetyl-L-alaninate anion through partial molar properties and molecular dynamics simulations
PublicationAmino acid ionic liquids (AAILs) provide a low toxicity, biodegradable alternative to conventional ionic liquids, while also maintaining solubility in water. Densities and sound velocities of aqueous solutions of four amino acid ionic liquids (AAILs), based on the N-alkyl-N-methylmorpholinium ([Mor1,R], R = 2, 3, 6, 8) cation and N-acetyl-L-alaninate ([N-Ac-L-Ala]) anion were measured at T = (293.15–313.15) K and at atmospheric...
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Blood Pressure Estimation Based on Blood Flow, ECG and Respiratory Signals Using Recurrent Neural Networks
PublicationThe estimation of systolic and diastolic blood pressure using artificial neural network is considered in the paper. The blood pressure values are estimated using pulse arrival time, and additionally RR intervals of ECG signal together with respiration signal. A single layer recurrent neural network with hyperbolic tangent activation function was used. The average blood pressure estimation error for the data obtained from 21 subjects...
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Separation of toluene from gas phase using supported imidazolium ionic liquid membrane
PublicationInvestigation on utilization of supported ionic liquids membranes for hydrocarbon separation from the gas phase was performed. Properties of membrane phase, wettability of supports, swelling effects and solubility of toluene were taken into account. Toluene permeation rates were significantly higher than those of pure nitrogen, the selectivity in a range of 17–341 was satisfying for separation. Despite the increase of viscosity...
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Steering is an essential feature of non-locality in quantum theory
PublicationA physical theory is called non-local when observers can produce instantaneous effects over distant systems. Non-local theories rely on two fundamental effects: local uncertainty relations and steering of physical states at a distance. In quantum mechanics, the former one dominates the other in a well-known class of non-local games known as XOR games. In particular, optimal quantum strategies for XOR games are completely determined...