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Evidence for consolidation of neuronal assemblies after seizures in humans
PublikacjaThe establishment of memories involves reactivation of waking neuronal activity patterns and strengthening of associated neural circuits during slow-wave sleep (SWS), a process known as "cellular consolidation" (Dudai and Morris, 2013). Reactivation of neural activity patterns during waking behaviors that occurs on a timescale of seconds to minutes is thought to constitute memory recall (O'Keefe and Nadel, 1978), whereas consolidation...
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Polysaccharide-based Nanocomposites for Biomedical Applications: A Critical Review
PublikacjaPolysaccharides (PSA) are taking specific position among biomaterials for advanced applications in medicine. Nevertheless, poor mechanical properties is known as the main drawback of PSA, which highlights need for PSA modification. Nanocomposites PSA (NPSA) are a class of biomaterials widely used as biomedical platforms, but despite their importance and worldwide use have not been reviewed. Herein we critically reviewed application...
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Fabrication methods of smart composite coatings - review
PublikacjaPostoperative bacterial infections are one of the main reasons for unsuccessful implantation of long-term implants. The development of bacterial infection requires antibiotic therapy, in extreme cases a reimplantation procedure is necessary. In order to provide materials for implants with antibacterial properties, they are subjected to modifications to create a coating that will release the drug substance, when the inflammation...
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The non-invasive evaluation of heart function in patients with an acute myocardial infarction: The role of impedance cardiography
PublikacjaBackground: The purpose of this study was to analyze hemodynamic changes in patients treated with percutaneous coronary intervention (PCI) at an early stage of acute myocardial infarction (AMI) and at one-month follow-up. Methods: Patients with AMI (n = 27) who underwent PCI were analyzed using impedance cardiography (ICG). ICG data were collected continuously (beat by beat) during the whole PCI procedure and thereafter at every...
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Successive cytotoxicity control by evolutionary surface decorated electronic push-pull green ZnCr-LDH nanostructures: Drug delivery enlargement for targeted breast cancer chemotherapy
PublikacjaThe reason for the increasing bioavailability and biocompatibility of the porous nanomaterials in the presence of different (bio)molecules is still unknown. The role of difference functional groups and their interactions with the potential bioavailability and biocompatibility is of great importance. To investigate the potential contribution of the electronic effects (especially on the surface of the porous nanomaterials) on their...
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Antibiotic Resistance of Uropathogens Isolated from Patients Hospitalized in District Hospital in Central Poland in 2020
PublikacjaThe aim of this study was to determine antibiotic resistance patterns and the prevalence of uropathogenes causing urinary tract infections (UTIs) in patients hospitalized in January–June 2020 in central Poland. Antimicrobial susceptibility testing was performed using the disk-diffusion method. Escherichia coli (52.2%), Klebsiella pneumoniae (13.7%), Enterococcus faecalis (9.3%), E. faecium (6.2%), and Proteus mirabilis (4,3%) were...
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Encapsulation of Amikacin into Microparticles Based on Low-Molecular-Weight Poly(lactic acid) and Poly(lactic acid-co-polyethylene glycol)
PublikacjaThe aim of this study was to fabricate novel microparticles (MPs) for efficient and long-term delivery of amikacin (AMI). The emulsification method proposed for encapsulating AMI employed low-molecular-weight poly(lactic acid) (PLA) and poly(lactic acid-co-polyethylene glycol) (PLA−PEG), both supplemented with poly(vinyl alcohol) (PVA). The diameters of the particles obtained were determined as less than 30 μm. Based on an in-vitro...
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Bortezomib induces methylation changes in neuroblastoma cells that appear to play a significant role in resistance development to this compound
PublikacjaThe anticancer activity of bortezomib (BTZ) has been increasingly studied in a number of indications and promising results for the use of this treatment have been shown in neuroblastoma. As BTZ treatment is usually administered in cycles, the development of resistance and side effects in patients undergoing therapy with BTZ remains a major challenge for the clinical usage of this compound. Common resistance development also means...
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Electrochemical degradation of textile dyes in a flow reactor: effect of operating conditions and dyes chemical structure
PublikacjaIn this study, electrochemical oxidation of five azo dyestuffs (Yellow D-5GN, Red D-B8, Ruby F-2B, Blue D-5RN, Black DN), that are widely used in the textile industry, was investigated in a flow reactor. BDD electrode with a high boron doping level (C/B = 10 000) was prepared and used. Two configurations of reactor were considered, i.e., one with the undivided cell, and the other with the cell divided by anodic and cathodic compartments....
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Nanocrystalline diamond microelectrode on fused silica optical fibers for electrochemical and optical sensing
PublikacjaFabrication process of thin boron-doped nanocrystalline diamond (B-NCD) microelectrode on fused silica single mode optical fiber has been investigated. The B-NCD films were deposited on the fibers using Microwave Plasma Assisted Chemical Vapor Deposition (MW PA CVD) at glass substrate temperature of 475 ºC. We have obtained homogenous, continuous and polycrystalline surface morphology with the mean grain size in the range of 100-250...
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A critical review on electrospun membranes containing 2D materials for seawater desalination
PublikacjaElectrospun nanofibers are a cutting-edge class of membranes which have been applied in several molecular separations. These membranes can be well designed and tailored due to the versatility of the electrospinning process. Eminently, electrospun membranes, once implemented in membrane processes, are an alternative in removing salts and some other minerals from water, so-called desalination, for producing drinking water. Such membranes...
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Diamond-Based Supercapacitors with Ultrahigh Cyclic Stability Through Dual-Phase MnO2-Graphitic Transformation Induced by High-Dose Mn-Ion Implantation
PublikacjaWhile occasionally being able to charge and dischargemore quickly than batteries, carbon-based electrochemical supercapacitors(SCs) are nevertheless limited by their simplicity of processing, adjustableporosity, and lack of electrocatalytic active sites for a range of redox reactions.Even SCs based on the most stable form of carbon (sp3carbon/diamond)have a poor energy density and inadequate capacitance retention during longcharge/discharge...
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Filip Kutt dr inż.
OsobyFilip Kutt was born in Gdansk, Poland. He received the M.Sc., PhD, degrees in electrical engineering in 2007 and 2013, respectively, all from Gdansk University of Technology (GUT) Poland. He is with GUT since 2007, currently as an Assistant Professor. His main scientific and research interests cover a wide spectrum of mathematical modelling of electrical machines using analytical modelling and FEM-based computations.
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Sebastian Lech Wachowski dr inż.
OsobyUrodziłem się w 1987 roku w Bydgoszczy. W 2007 roku ukończyłem Technikum Elektroniczne przy Zespole Szkół Elektroniczych w Bydgoszczy uzyskując tytuł zawodowy technika elektronika. W tym samy roku przeniosłem się do Gdańska gdzie rozpocząłem studnia na kierunku Fizyka Techniczna ze spec. Nanotechnologia na Wydziale Fizyki Technicznej i Matematyki Stosowanej Politechniki Gdańskiej. W 2011 uzyskuję tytuł inżyniera z wyróżnieniem...
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Computational methods for calculation of binding free energy for ligand-receptor complexes
PublikacjaAccurate description of the molecular complexes energetic influence is required for understanding of many biological functions carried out by proteins. Therefore, estimation of binding free energy for ligand-receptor complexes is of highest importance for structure-based ligand design and drug discovery approaches.Experimental methods of determination of difference in Gibbs'es free energy have many limitations. Thus, computational...
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Adam Inglot dr inż.
OsobyAdam Inglot (urodzony 3 października 1984 w Rzeszowie) studiował Inżynierię Środowiska oraz Geodezję i Kartografię na Wydziale Geodezji Górniczej i Inżynierii Środowiska Akademii Górniczo-Hutniczej w Krakowie. Inżynierię Środowiska ukończył w 2011 w stopniu mgr inż. broniąc pracę „Weryfikacja przydatności modelu GeoMod do prognozowania procesu urbanizacji w aglomeracji krakowskiej” u dra inż. Wojciecha Drzewieckiego. Natomiast...
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Assessing the Significance of Displacements Using Local Coefficients of Variance as an Alternative to the Classical Approach
PublikacjaThe safety of use of civil engineering structures remains an important issue that is approached by various sciences. Due to this fact, geodetic control measurements are conducted with the purpose of identifying threats connected with the potential displacement of structural elements. In this context, the authors discuss issues connected with determining the displacements of controlled points located in the studied object in a three-dimensional...
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Selected Aspect of IT Tools Application in Process Improvement in Industrial Laundry Services
PublikacjaThe laundry services sector in Poland is growing dynamically and currently has around 13,000 enterprises, mainly micro, small and medium size. The increasing competitiveness of this industry, causes more emphasis on solutions that can in-crease the efficiency of laundry processes and thereby strengthen the market position. One of the methods that can be used for this purpose is Lean Six Sigma, aided by specialized computer software....
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Interaction of Novel Ionic Liquids with Soils
PublikacjaWith the constant development of new ionic liquids, the understanding of the chemical fate of these compounds also needs to be updated. To this effect, in this contribution, the interaction of a number of novel ionic liquids with soils was determined. Therefore, three novel headgroups (ammonium, phosphonium or pyrrolidinium) with single or quaternary substitution were tested on a variety of soils with high to low organic matter...
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Kamila Klimaszewska dr inż.
OsobyUrodziła się w Warszawie (1979).W 1998 roku ukończyła I Liceum Ogólnokształcące im. Z. Krasińskiego w Ciechanowie i rozpoczęła studia na Wydziale Chemicznym Politechniki Gdańskiej. Po ich ukończeniu w 2003 rozpoczęła studia doktoranckie, uzyskując w 2008 roku stopień doktora nauk chemicznych w zakresie chemii (rozprawa doktorska „Osady atmosferyczne jako wskaźnik oceny stopnia zanieczyszczenia powietrza atmosferycznego”). W 2005...
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Władza misjonarzy. Zmierzch i świt świeckiej religii w Dolinie Krzemowej
Publikacja"Władza misjonarzy" to książka o misjonarskim zapale zmieniania świata i o kryzysie świeckiej religii towarzyszącej liderom nowych technologii, o ich świętokradztwach i sprofesjonalizowanej pokucie mającej przywrócić harmonię technologicznego raju na ziemi z Alphabetem, Metą, Apple i TikTokiem w roli głównej. Także o skruszonych inżynierach, żałujących każdej chwili, którą poświęcili na wymyślanie uzależniających algorytmicznych rozwiązań...
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Survey on opportunities and barriers in lighting controls
PublikacjaThis report summarizes a survey performed in eight countries on the status quo of daylight and electric lighting control systems. Feedback from more than 100 international experts (building / facility managers and planers) was evaluated. The aim of the survey was to identify the perception of the different possibilities of the current lighting control solutions and the expectations about the control systems. The survey aims to...
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Connected early-career experiences of equality in academia during the pandemic and beyond: Our liminal journey
PublikacjaIn this paper, we draw on our subjective experiences as two female early-career academics during the global COVID-19 pandemic. While we acknowledge that the pandemic had negative implications for many female scholars due to compulsory telework or increased family responsibilities, we also want to shed light on the empowering experiences shaped by collegial support that became an important part of our pandemic story. We build on...
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Krzysztof Wilde prof. dr hab. inż.
OsobyKrzysztof Wilde (ur. 11 I 1966 r. w Gdańsku) – specjalista z zakresu mostownictwa, mechaniki budowli, diagnostyki i geodezyjnego monitoringu konstrukcji inżynierskich. Prowadził badania ukierunkowane na opracowanie systemów redukcji drgań obiektów mostowych wywołanych działaniem wiatru i trzęsieniami ziemi. Prowadzi badania naukowe i prace rozwojowe związane z implementacją urządzeń i technologii diagnostyki nieniszczącej w obiektach...
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Activity of isavuconazole and other triazole derivatives against clinical isolates of Aspergillus fumigatus
PublikacjaAspergillus fumigatus is the most frequent pathogen of the genus Asperillus, which is highly susceptible to triazole derivatives, especially to isavuconazole and voriconazole. Many countries face a growing problem of infections due to A. fumigatus showing acquired resistance to one or several triazoles. In medical centres, monitoring the susceptibility of isolated Aspergillus spp. is recommended. The aim of this study was to collect...
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Drug-drug interaction potential of antitumor acridine agent C-1748: The substrate of UDP-glucuronosyltransferases 2B7, 2B17 and the inhibitor of 1A9 and 2B7
PublikacjaBackground The compound 9-(2′-hydroxyethylamino)-4-methyl-1-nitroacridine (C-1748), the promising antitumor agent developed in our laboratory was determined to undergo phase I metabolic pathways. The present studies aimed to know its biotransformation with phase II enzymes – UDP-glucuronosyltransferases (UGTs) and its potential to be engaged in drug-drug interactions arising from the modulation of UGT activity. Methods UGT-mediated...
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Modulation of UDP-glucuronidation by acridinone antitumor agents C-1305 and C-1311 in HepG2 and HT29 cell lines, despite slight impact in noncellular systems.
PublikacjaBackground Among the studied antitumor acridinone derivatives developed in our laboratory, 5-dimethylaminopropylamino-8-hydroxytriazoloacridinone (C-1305) and 5-diethylaminoethylamino-8-hydroxyimidazoacridinone (C-1311) exhibited cytotoxic and antitumor properties against several cancer types and were selected to be evaluated in preclinical and early-phase clinical trials. In the present work, we investigated the impact of C-1305...
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Long range molecular dynamics study of regulation of eukaryotic glucosamine-6-phosphate synthase activity by UDP-GlcNAc
PublikacjaGlucosamine-6-phosphate (GlcN-6-P) synthase catalyses the first and practically irreversible step in hexosamine metabolism. The final product of this pathway, uridine 5' diphospho N-acetyl-D-glucosamine (UDPGlcNAc), is an essential substrate for assembly of bacterialand fungal cell walls. Moreover, the enzyme is involved in phenomenon of hexosamine induced insulin resistance in type II diabetes, which makes it a potential target...
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Diminshed toxicity of C-1748, 4-methyl-9-hydroxyethylamino-1-nitroacridine, compared with its demethyl analog, C-857, corresponds to its resistance to metabolism in HepG2 cells
PublikacjaThe narrow "therapeutic window" of anti-tumour therapy may be the result of drug metabolism leading to the activation or detoxification of antitumour agents. The aim of this work is to examine (i) whether the diminished toxicity of a potent antitumour drug, C-1748, 9-(2'-hydroxyethylamino)-4-methyl-1-nitroacridine, compared with its 4-demethyl analogue, C-857, results from the differences between the metabolic pathways for the...
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Imidazoacridinone antitumor agent C-1311 as a selective mechanism- based inactivator of human cytochrome P450 1A2 and 3A4 isoenzymes.
Publikacja5-Diethylaminoethylamino-8-hydroxyimidazoacridinone (C-1311), a promising antitumor agent that is also active against autoimmune diseases, was determined to be a selective inhibitor of the cytochrome P450 (CYP) 1A2 and 3A4 isoenzymes. Therefore, C-1311 might modulate the effectiveness of other drugs used in multidrug therapy. The present work aimed to identify the mechanism of the observed C-1311-mediated inactivation of CYP1A2...
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Molecular basis and quantitative assessment of TRF1 and TRF2 protein interactions with TIN2 and Apollo peptides
PublikacjaShelterin is a six-protein complex (TRF1, TRF2, POT1, RAP1, TIN2, and TPP1) that also functions in smaller subsets in regulation and protection of human telomeres. Two closely related proteins, TRF1 and TRF2, make high-affinity contact directly with double-stranded telomeric DNA and serve as a molecular platform. Protein TIN2 binds to TRF1 and TRF2 dimer-forming domains, whereas Apollo makes interaction only with TRF2. To elucidate...
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Multifactor consciousness level assessment of participants with acquired brain injuries employing human–computer interfaces
PublikacjaBackground A lack of communication with people suffering from acquired brain injuries may lead to drawing erroneous conclusions regarding the diagnosis or therapy of patients. Information technology and neuroscience make it possible to enhance the diagnostic and rehabilitation process of patients with traumatic brain injury or post-hypoxia. In this paper, we present a new method for evaluation possibility of communication and the...
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Generation and Characterization of a DNA-GCN4 Oligonucleotide-Peptide Conjugate: The Impact DNA/Protein Interactions on the Sensitization of DNA
PublikacjaRadiotherapy, the most common therapy for the treatment of solid tumors, exerts its effects by inducing DNA damage. To fully understand the extent and nature of this damage, DNA models that mimic the in vivo situation should be utilized. In a cellular context, genomic DNA constantly interacts with proteins and these interactions could influence both the primary radical processes (triggered by ionizing radiation) and secondary reactions,...
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Teloxantron inhibits the processivity of telomerase with preferential DNA damage on telomeres
PublikacjaTelomerase reactivation is one of the hallmarks of cancer, which plays an important role in cellular immortalization and the development and progression of the tumor. Chemical telomerase inhibitors have been shown to trigger replicative senescence and apoptotic cell death both in vitro and in vivo. Due to its upregulation in various cancers, telomerase is considered a potential target in cancer therapy. In this study, we identified...
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Volatile Compound Emissions from Stereolithography Three-Dimensional Printed Cured Resin Models for Biomedical Applications
PublikacjaStereolithography three-dimensional printing is used increasingly in biomedical applications to create components for use in healthcare and therapy. The exposure of patients to volatile organic compounds (VOCs) emitted from cured resins represents an element of concern in such applications. Here, we investigate the biocompatibility in relation to inhalation exposure of volatile emissions of three different cured commercial resins...
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Genetic Background and Antibiotic Resistance Profiles of K. pneumoniae NDM-1 Strains Isolated from UTI, ABU, and the GI Tract, from One Hospital in Poland, in Relation to Strains Nationally and Worldwide
PublikacjaIn recent years, there has been an observed increase in infections caused by carbapenem-resistant Klebsiella pneumonia (Kp) strains. The aim of this study was the phenotypic and genotypic analysis of eight K. pneumoniae NDM (Kp NDM) isolates, recovered in Poland during the years 2016 and 2018 from seven patients with urinary tract infections (UTIs), asymptomatic bacteriuria (ABU), or colonization of the gut. PCR melting profile...
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Longitudinal drug synergy assessment using convolutional neural network image-decoding of glioblastoma single-spheroid cultures
PublikacjaAbstract Background In recent years, drug combinations have become increasingly popular to improve therapeutic outcomes in various diseases, including difficult to cure cancers such as the brain cancer glioblastoma. Assessing the interaction between drugs over time is critical for predicting drug combination effectiveness and minimizing the risk of therapy resistance. However, as viability readouts of drug combination experiments...
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Environmental characteristics of a tundra river system in Svalbard. Part 1: Bacterial abundance, community structure and nutrient levels
PublikacjaThe Arctic hosts a set of unique ecosystems, characterised by extreme environmental conditions and undergoing a rapid change resulting from the average temperature rising. We present a study on an aquatic ecosystem of the Revelva catchment (Spitsbergen), based on samples collected from the lake, river and their tributaries, in the summer of 2016. The landscape variety of the study site and the seasonal change in the hydrological...
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Research on Tool Temperature Dependence on Lapping Grains Size
PublikacjaCommonly used as a finishing operation, lapping has been used for achieving ultra-high finishes and close tolerances between mating pieces. Its carried out by applying loose abrasive grains between work and lap surfaces, and causing a relative motion between them resulting in a finish of multi-directional lay. The grains activity (sliding and rolling) in the working gap causes not only the material removal but also the temperature...
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Tailoring diamondised nanocarbon-loaded poly(lactic acid) composites for highly electroactive surfaces: extrusion and characterisation of filaments for improved 3D-printed surfaces
PublikacjaA new 3D-printable composite has been developed dedicated to electroanalytical applications. Two types of diamondised nanocarbons - detonation nanodiamonds (DNDs) and boron-doped carbon nanowalls (BCNWs) - were added as fillers in poly(lactic acid) (PLA)-based composites to extrude 3D filaments. Carbon black served as a primary filler to reach high composite conductivity at low diamondised nanocarbon concentrations (0.01 to 0.2...
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Collocations et représentation féminine dans les oeuvres de Colette : Une analyse linguistique et littéraire
PublikacjaSidonie-Gabrielle Colette played a significant role in the development of French literature. Her novels vividly depict independent and self-aware women, thereby reflecting the author herself. Colette’s works have captured the attention of researchers and have been the subject of numerous studies. In this proposed research, an interdisciplinary approach combining literary and linguistic perspectives is adopted to explore Colette’s...
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The mechanical properties and bactericidal degradation effectiveness of tannic acid-based thin films for wound care
PublikacjaThe surface area is the most important aspect when considering the interactions between a material and the surrounding environment. Chitosan (CTS) and tannic acid (TA) were previously successfully tested by us to obtain thin films to serve as wound dressings or food packaging materials. However, surface properties as well as the antimicrobial activity of the material were not considered. They are important if the material is likely...
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Analysis of the Capability of Deep Learning Algorithms for EEG-based Brain-Computer Interface Implementation
PublikacjaMachine learning models have received significant attention for their exceptional performance in classifying electroencephalography (EEG) data. They have proven to be highly effective in extracting intricate patterns and features from the raw signal data, thereby contributing to their success in EEG classification tasks. In this study, we explore the possibilities of utilizing contemporary machine learning algorithms in decoding...
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O problemie kolmatacji geowłóknin stosowanych w drenażach
PublikacjaSystemy drenażowe występujące przy obiektach drogowych są niezwykle istotnym elementem tych budowli. Jednym z materiałów, które obecnie powszechnie stosowane są w systemach drenażowych są geowłókniny. Ich zadaniem jest zabezpieczenie odwadnianego gruntu przed procesem sufozji, jak również ochrona drenażu przed zamuleniem przy jednoczesnym zachowaniu wodoprzepuszczalności. Typową trwałość drenażu, w zależności od rozwiązań, szacować...
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Mariusz Figurski prof. dr hab. inż.
OsobyDyrektor Centrum Modelowania Meteorologicznego Instytut Meteorologii i Gospodarki Wodnej - Państwowy Instytut Badawczy. Urodził się 27 kwietnia 1964 roku w Łasinie. Egzamin maturalny złożył w 1983 roku po ukończeniu II Liceum Ogólnokształcącego im. Jana III Sobieskiego w Grudziądzu, Studia wyższe w trybie indywidualnym ukończył w 1989 (10.07.1989) na Wydziałach Elektromechanicznym i Inżynierii Lądowej i Geodezji Wojskowej Akademii...
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Hidden Tensor Structures
PublikacjaAny single system whose space of states is given by a separable Hilbert space is automatically equipped with infinitely many hidden tensor-like structures. This includes all quantum mechanical systems as well as classical field theories and classical signal analysis. Accordingly, systems as simple as a single one-dimensional harmonic oscillator, an infinite potential well, or a classical finite-amplitude signal of finite duration...
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Optimizing Construction Engineering Management Using Metaheuristic Methods and Bayesian Networks
PublikacjaThe construction of buildings invariably involves time and costs, and disruptions impact ongoing construction projects. Crisis situations in management strategies, structural confusion, and finan-cial miscalculations often arise due to misguided decision-making. This article proposes a method that combines the learning of Bayesian Networks and heuristic techniques to optimize deci-sion-making processes in construction scheduling....
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Effect of osmolytes on the thermal stability of proteins: replica exchange simulations of Trp-cage in urea and betaine solutions
PublikacjaAlthough osmolytes are known to modulate the folding equilibrium, the molecular mechanism of their effect on thermal denaturation of proteins is still poorly understood. Here, we simulated the thermal denaturation of a small model protein (Trp-cage) in the presence of denaturing (urea) and stabilizing (betaine) osmolytes, using the all-atom replica exchange molecular dynamics simulations. We found that urea destabilizes Trp-cage...
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Making agile retrospectives more awesome
PublikacjaAccording to the textbook [23], Scrum exists only in its entirety, where every component is essential to Scrum’s success. However, in many organizational environments some of the components are omitted or modified in a way that is not aligned with the Scrum guidelines. Usually, such deviations result in missing the full benefits of Scrum [24]. Thereby, a Scrum process should be frequently inspected and any deviations should be...
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Evaluation and start-up of an electro-Fenton-sequencing batch reactor for dairy wastewater treatment
PublikacjaThis study examined the performance of an integrated wastewater (WW) treatment system, namely an electro-Fenton (EF)-sequencing batch reactor (SBR), for dairy industry WW. The EF process was used as the first stage of the SBR. It degrades bio-refractory compounds via advanced oxidation processes, thereby resulting in the formation of simple biodegradable intermediates. Several factors, including the hydraulic retention time (HRT),...