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Novel benzenesulfonamide-aroylhydrazone conjugates as carbonic anhydrase inhibitors that induce MAPK/ERK-mediated cell cycle arrest and mitochondrial-associated apoptosis in MCF-7 breast cancer cells
PublicationA series of novel 4-alkylthio-2-chloro-5-[(2-arylmethylidene)hydrazinecarbonyl]benzenesulfonamide derivatives 3–22 were synthesized and evaluated for their inhibitory activity against human carbonic anhydrase isozymes hCA I, hCA II, hCA IX, and hCA XII. These compounds showed varying degrees of activity against the studied isoenzymes. However, the importance of substituent choice in designing potent carbonic anhydrase inhibitors...
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On-line P-coloring of graphs
PublicationFor a given induced hereditary property P, a P-coloring of a graph G is an assignment of one color to each vertex such that the subgraphs induced by each of the color classes have property P. We consider the effectiveness of on-line P-coloring algorithms and give the generalizations and extensions of selected results known for on-line proper coloring algorithms. We prove a linear lower bound for the performance guarantee function...
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Saccharides
PublicationSaccharides are widely distributed in nature as the major component of fruits and vegetables (primarily monosaccharides), milk and malt (mainly disaccharides), and grains (mostly polysaccharides). They are an important source of energy, structural material, as well as flavor and taste factors. Molecules of this class of compounds contain mainly carbon, hydrogen, and oxygen atoms; however, most natural saccha- rides do not have...
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Analytical progress on symmetric geometric discord: Measurement-based upper bounds
PublicationQuantum correlations may be measured by means of the distance of the state to the subclass ofstates having well defined classical properties. In particular, a geometric measure of asymmetricdiscord [Daki´c et al., Phys. Rev. Lett. 105, 190502 (2010)] was recently defined as the Hilbert-Schmidt distance of a given two-qubit state to the closest classical-quantum (CQ) correlated state.We analyze a geometric measure of symmetric...
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The influence of phosphorus fractions in bottom sediments on phosphate removal in semi-natural systems as the 3rd stage of biological wastewater treatment
PublicationThe research was carried out in two semi-natural systems (the polishing ponds in Swarzewo and the free water surface constructed wetland in Zarnowiec) in Poland. They were built as the 3rd stage of a conventional mechanical–biological wastewater treatment plant. These systems were built to improve the quality of the effluent of treated wastewater. In the polishing ponds and FWS wetland system, suspended solids, organic matter as...
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Aplikacje i usługi a technologie sieciowe
PublicationObserwując tempo rozwoju technologii sieciowych oraz usług i aplikacji stajemy przed ogromnym dylematem jak wykorzystać istniejące możliwości by modernizować wybrane usługi i aplikacje zgodnie z ciągle zmieniającymi się potrzebami użytkowników. Bardzo często sygnalizowane nowe technologie czy aplikacje mają jednak czysto charakter biznesowy podporządkowany prawom marketingu i nie wnoszą wielu istotnych zmian. Dlatego jest ważne...
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Moda jako wartość konsumencka - eksplikacja zagadnienia
PublicationCel: Celem artykułu jest przedstawienie problematyki mody jako propozycji wartości dla klienta. Realizacja niniejszego celu wymagała uszczegółowionej eksplikacji zjawiska mody. W publikacji zdefiniowaniu poddano mechanizm działania mody, istotę trendu mody, jak również omówiono główne perspektywy analizy mody oraz aktualne nurty badań nad modą. Projekt badania/metodyka badawcza/koncepcja: W pracy wykorzystano metodę krytycznej...
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Integrating heterogeneous systems with high-dependability requirements by means of web services
PublicationWeb services are commonly used on boundaries of heterogeneous components in Service Oriented Architecture (SOA) as they provide a universal communication channel not bound to any particular programming language or run-time platform. This paper describes how web services can be used to integrate heterogeneous systems which serve purposes requiring high dependability, reliability and availability. Examples of such systems include...
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Exploration of optical fibres as a carrier for new benzene and toluene matrix-free reference materials
PublicationTo meet high expectations concerning precision and accuracy of reference materials, preparation of matrixfree reference materials using thermal decomposition-gas chromatography-mass spectrometry (TD-GC-MS) was proposed in this study. In the paper, the results obtained in preparation of the new reference materials for benzene and toluene are presented, based on the thermal decomposition technique of compounds chemically bound to...
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Four-body recombination in organic bulk heterojunction solar cells: an alternative interpretation
PublicationWe demonstrate a new interpretation of the previously reported quadrimolecular recombination in organic bulk heterojunction solar cells. It is suggested that the recently described (Szmytkowski 2012 Phys. Status Solidi RRL 6 300) interaction between exciton and electron–hole Langevin bound pair formed across the donor–acceptor interface is a four-particle process. This is in opposition to the treatment of this effect as a three-particle...
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Mechanical, Thermal and Rheological Properties of Polyethylene-Based Composites Filled with Micrometric Aluminum Powder
PublicationInvestigations related to polymer/metal composites are often limited to the analysis of the electrical and thermal conductivity of the materials. The presented study aims to analyze the impact of aluminum (Al) filler content (from 1 to 20 wt%) on the rarely investigated properties of composites based on the high-density polyethylene (HDPE) matrix. The crystalline structure, rheological (melt flow index and oscillatory rheometry),...
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Agri-food waste biosorbents for volatile organic compounds removal from air and industrial gases – A review
PublicationApproximately 1.3 billion metric tons of agricultural and food waste is produced annually, highlighting the need for appropriate processing and management strategies. This paper provides an exhaustive overview of the utilization of agri-food waste as a biosorbents for the elimination of volatile organic compounds (VOCs) from gaseous streams. The review paper underscores the critical role of waste management in the context of a...
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Controlling nodal displacement of pantographic structures using matrix condensation and interior-point optimization: A numerical and experimental study
PublicationThis study presents an innovative approach for the precise control of nodal displacements in pantographic structures. The method is founded on the Matrix Condensation of Force Method, seamlessly integrated with an Interior Point Optimization algorithm. This combination offers a unique advantage by allowing users to manipulate displaced nodes within a defined coordination domain. Furthermore, this approach introduces the Interior...
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Nanotechnologia w architekturze – korzyści i problemy wynikające z zastosowania nanotechnologii w aspekcie cyklu życia budynku
PublicationDynamiczny rozwój technologii zawsze odgrywał ważną rolę w procesie kształtowania architektury. Postęp w dziedzinie inżynierii materiałowej już od Rewolucji Przemysłowej pozwalał na osiąganie co raz bardziej skomplikowanych i jednocześnie wytrzymałych konstrukcji budynków. Obecnie, w dziedzinie architektury, zaczyna pojawiać się pojęcie nanotechnologii, która pozwala zmieniać stosowane materiały w bardziej wydajne i odporne....
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Elimination of dominated partial schedules in scheduling deteriorating jobs
Publicationw artykule rozważany jest problem szeregowania zadań uwarunkowanych czasowo, w notacji trójpolowej opisywany przez 1 | pi = a + bisi | ?ci. wprowadzona jest koncepcja zdominowanych częściowych harmonogramów oraz przedstawiony jest niewielomianowy algorytm dla problemu, który bazuje na eliminacji zdominowanych częściowych harmonogramów. przedstawione są wyniki eksperymentów obliczeniowych, porównujących zaprezentowany algorytm oraz...
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Structure of EstA esterase from psychrotrophic Pseudoalteromonas sp. 643A covalently inhibited by monoethylphosphonate.
PublicationThe crystal structure of the esterase EstA from the cold-adapted bacteriumPseudoalteromonas sp. 643A was determined in a covalently inhibited form at aresolution of 1.35 A˚. The enzyme has a typical SGNH hydrolase structureconsisting of a single domain containing a five-stranded beta-sheet, with threehelices at the convex side and two helices at the concave side of the sheet, and isornamented with a couple of very short helices...
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Interval incidence coloring of bipartite graphs
PublicationIn this paper we study the problem of interval incidence coloring of bipartite graphs. We show the upper bound for interval incidence coloring number (χii) for bipartite graphs χii≤2Δ, and we prove that χii=2Δ holds for regular bipartite graphs. We solve this problem for subcubic bipartite graphs, i.e. we fully characterize the subcubic graphs that admit 4, 5 or 6 coloring, and we construct a linear time exact algorithm for subcubic...
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Calculation of electron scattering lengths on Ar, Kr, Xe, Rn and Og atoms
PublicationFocusing on the noble gases, we calculate the scattering potential using the Dirac-Coulomb Hamiltonian supplemented with a model polarization potential. We determine the scattering lengths using two methods, namely phase shifts for very small scattering energies and the shape of the wave function for zero scattering energy. We compare our theoretical electron scattering length results on Ar, Kr and Xe atoms with existing experimental...
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How to meet when you forget: log-space rendezvous in arbitrary graphs
PublicationTwo identical (anonymous) mobile agents start from arbitrary nodes in an a priori unknown graph and move synchronously from node to node with the goal of meeting. This rendezvous problem has been thoroughly studied, both for anonymous and for labeled agents, along with another basic task, that of exploring graphs by mobile agents. The rendezvous problem is known to be not easier than graph exploration. A well-known recent result...
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Intra-operative biopsy in chronic sinusitis detects pathogenic Escherichia coli that carry fimG/H, fyuA and agn43 genes coding biofilm formation
PublicationThe aim of this study was to investigate whether or not surgical biopsy of sinus tissue in chronic sinusitis, not responsive to treatment, would detect E. coli. We intended to evaluate E. coli virulence genes, therefore dispute the causal role of such an unusual microorganism in chronic sinusitis, as well as consider effective pathogen-targeted therapy. Patients with E. coli isolated by intra-operative puncture biopsy were included...
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The Business Environment of Georgia and Ukraine: Approaches to a Comparative Analysis
PublicationThe formation of a favourable business environment and the intensification of entrepreneurial activity on this basis is one of the priorities of economic policy of governments around the world. The aim of this article is to conduct a comparative analysis of some of the characteristics of the business environment of Georgia and Ukraine. The theoretical basis of the study is the understanding of the business environment as a necessary...
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Highly Conserved Homotrimer Cavity Formed by the SARS-CoV-2 Spike Glycoprotein: A Novel Binding Site
PublicationAn important stage in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) life cycle is the binding of the spike (S) protein to the angiotensin converting enzyme-2 (ACE2) host cell receptor. Therefore, to explore conserved features in spike protein dynamics and to identify potentially novel regions for drugging, we measured spike protein variability derived from 791 viral genomes and studied its properties by molecular...
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Statistically efficient smoothing algorithm for time-varying frequency estimation
PublicationThe problem of extraction/elimination of a nonstationary sinusoidal signal from noisy measurements is considered. This problem is usually solved using adaptive notch filtering (ANF) algorithms. It is shown that the accuracy of frequency estimates can be significantly increased if the results obtained from ANF are backward-time filtered by an appropriately designed lowpass filter. The resulting adaptive notch smoothing (ANS) algorithm...
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A simple test for quantum channel capacity
PublicationBased on state and channel isomorphism we point out that semidefiniteprogramming can be used as a quick test for nonzero one-way quantum channelcapacity. This can be achieved by searching for symmetric extensions of statesisomorphic to a given quantum channel. With this method we provide examplesof quantum channels that can lead to high entanglement transmission but stillhave zero one-way capacity, in particular, regions of symmetric...
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Relativistic two-dimensional hydrogen-like atom in a weak magnetic field
PublicationA two-dimensional (2D) hydrogen-like atom with a relativistic Dirac electron, placed in a weak, static, uniform magnetic field perpendicular to the atomic plane, is considered. Closed forms of the first- and second-order Zeeman corrections to energy levels are calculated analytically, within the framework of the Rayleigh–Schrödinger perturbation theory, for an arbitrary electronic bound state. The second-order calculations are...
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AMCA to TAMRA long range resonance energy transfer on a flexible peptide
PublicationFörster resonance energy transfer between 7-amino-4-methyl-3-coumarinylacetic acid, (AMCA, donor) and 5- carboxytetramethylrhodamine, (TAMRA, acceptor) bound to Lys(AMCA)-Gly-Pro-Arg-Ser-Leu-Ser-Gly-Lys (TAMRA)-NH2 peptide is demonstrated by various spectroscopic techniques in glycerol at room temperature. In particular, nonexponential character of fluorescence intensity decay evidences the distance distribution between the donor...
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Sensor Position Estimation Method for IoT Using Mobile Reference Node
PublicationThe paper proposes an innovative method of locating objects for the Internet of Things (IoT). The proposed method allows the position of a fixed measuring sensor (MS) to be estimated using one mobile base station with a known position moving around the MS. The mathematical analysis of the method, and three algorithms — Newton’s (NA), gradient descent (GD) and genetic (GA) — for solving the system of non-linear positional equations...
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2-Coloring number revisited
Publication2-Coloring number is a parameter, which is often used in the literature to bound the game chromatic number and other related parameters. However, this parameter has not been precisely studied before. In this paper we aim to fill this gap. In particular we show that the approximation of the game chromatic number by the 2-coloring number can be very poor for many graphs. Additionally we prove that the 2-coloring number may grow...
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Isolation Number versus Domination Number of Trees
PublicationIf G=(VG,EG) is a graph of order n, we call S⊆VG an isolating set if the graph induced by VG−NG[S] contains no edges. The minimum cardinality of an isolating set of G is called the isolation number of G, and it is denoted by ι(G). It is known that ι(G)≤n3 and the bound is sharp. A subset S⊆VG is called dominating in G if NG[S]=VG. The minimum cardinality of a dominating set of G is the domination number, and it is denoted by γ(G)....
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Pozytywne doświadczenia zakupowe w kreowaniu lojalności nabywczej
PublicationDoświadczenie zakupowe to rodzaj mentalnej podróży, pozostawiającej niematerialne wrażenia, w postaci wiedzy i śladu emocjonalnego [69], będące kluczowym elementem w zrozumieniu zachowań konsumentów, jak również istotnych zmian zachodzących we współczesnym marketingu [10]. Cel: Celem głównym badań było ukazanie wpływu pozytywnych doświadczeń zakupowych na kształtowanie satysfakcji i lojalności nabywczej oraz sposobów budowania...
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Cold recycled mixtures for binder courses - laboratory evaluation of mechanical properties
PublicationCold recycled mixtures composed with cement and bituminous emulsion are nowadays commonly used material for base layer. Typical pavement with cold recycled mixtures usually consists of two asphalt courses (wearing and binding course) constructed over cold recycled base. Therefore the next step in cold recycling is possibility of design of binding courses with recycled materials, but with potential to obtain high quality mixtures...
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From the multiple frequency tracker to the multiple frequency smoother
PublicationThe problem of extraction/elimination of nonstationary sinusoidalsignals from noisy measurements is considered. This problem is usually solved using adaptive notch filtering (ANF)algorithms. It is shown that the accuracy of frequency estimates can be significantly increased if the results obtained from ANF are backward-time filtered by an appropriately designed lowpass filter. The resulting adaptive notch smoothing (ANS)algorithm...
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Partial dominated schedules and minimizing the total completion time of deteriorating jobs
PublicationA problem of scheduling deteriorating jobs on a single processor is considered. The processing time of a job is given by a function pi=ai+bisi, where si is the starting time of the job, ai>=0, bi>=0, for i=1,...,n. Jobs are non-preemptive and independent and there are neither ready times nor deadlines. The goal is to minimize the total weighted completion time. We show how to employ the concept of non-dominated schedules to construct...
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Nanotubular oxide layers and hydroxyapatite coatings on ‘Ti–13Zr–13Nb’ alloy
PublicationThe presented research was aimed to determine the mechanical properties of the nanotubular oxide layer covered with hydroxyapatite coating. The Ti–13Zr–13Nb alloy was oxidised in 1M phosphoric acid with an addition of 0?5% HF for HF solution at 20 V voltage. The electrochemically assisted deposition of hydroxyapatite was performed at cyclic polarisation in NH4H2PO4 and CaCl2 solution at 80uC. The mechanical properties were determined...
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Elemental and tight monogamy relations in nonsignaling theories
PublicationPhysical principles constrain the way nonlocal correlations can be distributed among distant parties. These constraints are usually expressed by monogamy relations that bound the amount of Bell inequality violation observed among a set of parties by the violation observed by a different set of parties. We prove here that much stronger monogamy relations are possible for nonsignaling correlations by showing how nonlocal correlations...
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Collision-free network exploration
PublicationMobile agents start at different nodes of an n-node network. The agents synchronously move along the network edges in a collision-free way, i.e., in no round two agents may occupy the same node. An agent has no knowledge of the number and initial positions of other agents. We are looking for the shortest time required to reach a configuration in which each agent has visited all nodes and returned to its starting location. In...
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On-line Search in Two-Dimensional Environment
PublicationWe consider the following on-line pursuit-evasion problem. A team of mobile agents called searchers starts at an arbitrary node of an unknown network. Their goal is to execute a search strategy that guarantees capturing a fast and invisible intruder regardless of its movements using as few searchers as possible. As a way of modeling two-dimensional shapes, we restrict our attention to networks that are embedded into partial grids:...
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From unextendible product bases to genuinely entangled subspaces
PublicationUnextendible product bases (UPBs) are interesting mathematical objects arising in composite Hilbert spaces that have found various applications in quantum information theory, for instance in a construction of bound entangled states or Bell inequalities without quantum violation. They are closely related to another important notion, completely entangled subspaces (CESs), which are those that do not contain any fully separable pure...
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99mTc-Galacto-RGD2: A Novel 99mTc-Labeled Cyclic RGD Peptide Dimer Useful for Tumor Imaging
PublicationThis study sought to evaluate [99mTc(HYNIC-Galacto-RGD2)-(tricine)(TPPTS)] (99mTc-Galacto-RGD2: HYNIC = 6-hydrazinonicotinyl; Galacto-RGD2 = Glu[cyclo[Arg-Gly-Asp-D-Phe-Lys(SAA-PEG2-(1,2,3-triazole)-1-yl-4-ethylamide)]]2 (SAA = 7-amino-L-glycero-L-galacto-2,6-anhydro-7-eoxyheptanamide, and PEG2 = 3,6-dioxaoctanoic acid); and TPPTS = trisodium triphenylphosphine-3,3',3''-trisulfonate) as a new radiotracer for tumor imaging. Galacto-RGD2...
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Analysis of Attitudes of Internet Users Towards the Brand in Social Media
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Dissecting gamma frequency activities during human memory processing
PublicationGamma frequency activity (30-150 Hz) is induced in cognitive tasks and is thought to reflect underlying neural processes. Gamma frequency activity can be recorded directly from the human brain using intracranial electrodes implanted in patients undergoing treatment for drug-resistant epilepsy. Previous studies have independently explored narrowband oscillations in the local field potential and broadband power increases. It is not...
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EM-Driven Size Reduction and Multi-Criterial Optimization of Broadband Circularly-Polarized Antennas Using Pareto Front Traversing and Design Extrapolation
PublicationMaintaining small size has become an important consideration in the design of contemporary antenna structures. In the case of broadband circularly polarized (CP) antennas, miniaturization is a challenging process due to the necessity of simultaneous handling of electrical and field properties (reflection, axial ratio, gain), as well as ensuring sufficient frequency range of operation, especially at the lower edge of the antenna...
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Sub-national structures matter when evaluating physical activity promotion: Lessons from Germany
PublicationBackground Public policies are increasingly acknowledged as important part of promoting physical activity (PA). However, especially in states with sub-national administrative structures such as Germany, national and sub-national approaches differ considerably. In Germany, sport for all (SfA) promotion is mostly organized at sub-national level, which is usually not covered in national evaluations. Knowledge of these structures helps...
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Performance of electrochemical immunoassays for clinical diagnostics of SARS-CoV-2 based on selective nucleocapsid N protein detection: Boron-doped diamond, gold and glassy carbon evaluation
PublicationThe 21st century has already brought us a plethora of new threats related to viruses that emerge in humans after zoonotic transmission or drastically change their geographic distribution or prevalence. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was first spotted at the end of 2019 to rapidly spread in southwest Asia and later cause a global pandemic, which paralyzes the world since then. We have designed novel...
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Synchronous black hole search in directed graphs
PublicationThe paper considers a team of robots which has to explore a graph G, where some nodes can be harmful. Robots are initially located at the so-called home base node. The dangerous nodes are the so-called black hole nodes, and once a robot enters in one of them, it is destroyed. The goal is to find a strategy in order to explore G in such a way that minimum number of robots is wasted. The exploration ends if there is at least one...
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The quality of sewage sludge stabilized for a long time in reed basins
PublicationThe aim of the work was to determine changes of long-term sewage sludge quality stabilized in reed basins from 7-15 years. The following parameters were evaluated: dry matter and organic matter concentration, nitrogen, phosphorus, and selected heavy metal (Cd, Ni, Pb, Cr, Cu, Zn) fractions. The material for the investigations was collected from 4 reed basin systems (utilisated sewage sludge) located in conventional WWTPs in Denmark...
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Zastosowanie metody podziału i ograniczeń w wielokryterialnym problemie podziału hw/sw do implementacji algorytmów kryptograficznych
PublicationW niniejszej pracy przedstawiono zastosowanie metody podziału i ograniczeń B&B (ang. Branch and Bound) do problemu podziału funkcjonalności między sprzęt i oprogramowanie. Metoda B&B daje rozwiązanie optymalne, ma jednak wykładniczą złożoność obliczeniową. Przyspieszenie uzyskiwane jest na drodze eliminacji nierokujących gałęzi w przestrzeni poszukiwań, a jej kluczowym elementem jest definicja funkcji ograniczenia dolnego. W niniejszej...
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Optimal and suboptimal algorithms for identification of time-varying systems with randomly drifting parameters
PublicationNoncausal estimation algorithms, which involve smoothing, can be used for off-line identification of nonstationary systems. Since smoothingis based on both past and future data, it offers increased accuracy compared to causal (tracking) estimation schemes, incorporating past data only. It is shown that efficient smoothing variants of the popular exponentially weighted least squares and Kalman filter-based parameter trackers can...
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Specific Binding of Cholesterol to the Amyloid Precursor Protein: Structure of the Complex and Driving Forces Characterized in Molecular Detail
PublicationC99 is the C-terminal membrane-bound fragment of the amyloid precursor protein that is cleaved by γ-secretase to release Aβ peptides, the hallmark of Alzheimer’s disease (AD). Specific interactions of C99 with cholesterol have been proposed to underlie the recognized role of cholesterol in promoting amyloidogenesis. By using molecular dynamics simulations, we studied cholesterol binding to C99 in a lipid bilayer. We determined...
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Risks related to car fire on innovative Poroelastic Road Surfaces-PERS
PublicationTo reduce tyre/road noise, the concept of poroelastic road surfaces (PERS) was invented. PERS is a road surface material that is porous, and at the same time, it is flexible because of the substantial amount of rubber granulate content (from 20% to 85%). The rubber and stone particles are bound by polyurethane resin instead of bitumen. It was feared that in case of fire, because of the high content of rubber and polyurethane, there...