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Wyniki wyszukiwania dla: IN SILICO METABOLISM PREDICTION
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Sensing Direction of Human Motion Using Single-Input-Single-Output (SISO) Channel Model and Neural Networks
PublikacjaObject detection Through-the-Walls enables localization and identification of hidden objects behind the walls. While numerous studies have exploited Channel State Information of Multiple Input Multiple Output (MIMO) WiFi and radar devices in association with Artificial Intelligence based algorithms (AI) to detect and localize objects behind walls, this study proposes a novel non-invasive Through-the-Walls human motion direction...
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Study on the accuracy of axle load spectra used for pavement design
PublikacjaWeigh-in-Motion (WIM) systems are used in order to reduce the number of overloaded vehicles. Data collected from WIM provide characteristics of vehicle axle loads that are crucial for pavement design as well as for the development of pavement distress prediction models. The inaccuracy of WIM data lead to erroneous estimation of traffic loads and in consequence inaccurate prediction of pavement distress process. The objective of...
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Edgewise Compressive Behavior of Composite Structural Insulated Panels with Magnesium Oxide Board Facings
PublikacjaEdgewise compression response of a composite structural insulated panel (CSIP) with magnesium oxide board facings was investigated. The discussed CSIP is a novel multifunctional sandwich panel introduced to the housing industry as a part of the wall, floor, and roof assemblies. The study aims to propose a computational tool for reliable prediction of failure modes of CSIPs subjected to concentric and eccentric axial loads. An advanced...
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Data on LEGO sets release dates and worldwide retail prices combined with aftermarket transaction prices in Poland between June 2018 and June 2023
PublikacjaThe dataset contains LEGO bricks sets item count and pricing history for AI-based set pricing prediction. The data spans the timeframe from June 2018 to June 2023. The data was obtained from three sources: Brickset.com (LEGO sets retail prices, release dates, and IDs), Lego.com official web page (ID number of each set that was released by Lego, its retail prices, the current status of the set) and promoklocki.pl web page (the retail...
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Effect of Maximal Breath Hold Apnea on Pial Artery Pulsation and Subarachnoid Width in Human
PublikacjaLittle is known about intracranial pressure (ICP)-cerebral hemodynamic interplay during maximal breath-hold apnea. A recently developed method based on near-infrared transillumination/backscattering sounding (NIR-T/BSS) noninvasively measures changes in pial artery pulsation (cc-TQ) as well as subarachnoid width (sas-TQ) in humans. Changes in sas-TQ correlate with ICP to a considerable extent, whereas cc-TQ reflects the functional...
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Novel Resveratrol-Based Substrates for Human Hepatic, Renal, and Intestinal UDP-Glucuronosyltransferases
PublikacjaTrans-Resveratrol (tRes) has been shown to have powerful antioxidant, anti-inflammatory, anti-carcinogenic, and anti-aging properties; however, its use as a therapeutic agent is limited by its rapid metabolism into its conjugated forms by UDP-Glucuronosyltransferases (UGTs). The aim of the current study was to test the hypothesis that the limited bioavailability of tRes can be improved by modifying its structure to create analogs...
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ANALYSIS OF POSSIBILITIES FOR THE USE OF VOLUME-DELAY FUNCTIONS IN THE PLANNING MODULE OF THE TRISTAR SYSTEM
PublikacjaTravel time is a measure commonly used for traffic flow modelling and traffic control. It also helps to evaluate the quality of traffic control systems in urban areas. Traffic control systems that use traffic models to predict changes and disruptions in vehicle flows have to use vehicle speed-prediction models. Travel time estimation studies the effects of traffic volumes on a street section at an average speed. The TRISTAR Integrated...
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Predicting Ice Phenomena in a River Using the Artificial Neural Network and Extreme Gradient Boosting
PublikacjaForecasting ice phenomena in river systems is of great importance because these phenomena are a fundamental part of the hydrological regime. Due to the stochasticity of ice phenomena, their prediction is a difficult process, especially when data sets are sparse or incomplete. In this study, two machine learning models—Multilayer Perceptron Neural Network (MLPNN) and Extreme Gradient Boosting (XGBoost)—were developed to predict...
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The occurence and diagnosis of biomarkers of ethyl alcohol consumption
PublikacjaEthyl alcohol is a legal and a widely available psychoactive drug. However, its excessive consumption causes addiction. This leads to aggressive behaviors, family battery, difficulties in interpersonal relations, legal offences, suicides, car accidents and deterioration in labor productivity, what causes financial problems. Despite many social actions against alcohol consumption, this problem is still unresolved. Therefore, fast...
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Fundamenty palowe, obliczenia z zastosowaniem zasad Eurokodu 7 i doświadczeń krajowych
PublikacjaPrzedstawiono zagadnienia obliczania fundamentów palowych w nawiązaniu do zaleceń Eurokodu 7. Zwrócono uwagę, że zgodnie z założeniami Eurokodu 7, projektant i inżynier ma swobodę w wyborze metod obliczeniowych.Przytoczono i zarekomendowano metody i propozycje miedzy innymi obliczania statycznego układów palowych, określania nośności pali, prognozowania osiadań fundamentów palowych oraz charakterystyk obciążenie-osiadanie pali...
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GIS Solution for Weather Forecast Data Analysis
PublikacjaIn this paper authors present the GIS system for the analysis of the numerical weather prediction data. This kind of data has multidimensional character (three dimensions and time) and its analysis should consider all the available factors. Proposed GIS system consists of RASDAMAN application with implemented OLAP cube mechanism, which enables the user to process data in the spatial-time domain. It also simplifies the meteorological...
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A new quantum-inspired approach to reduce the blocking probability of demands in resource-constrained path computation scenarios
PublikacjaThis article presents a new approach related with end-to-end routing, which, owing to quantum-inspired mecha-nisms of prediction of availability of network resources, results in improved blocking probability of incoming requests to establish transmission paths. The proposed scheme has been analyzed for three network topologies and several scenarios of network load. Obtained results show a significant (even twofold) reduction of...
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Optimized Deep Learning Model for Flood Detection Using Satellite Images
PublikacjaThe increasing amount of rain produces a number of issues in Kerala, particularly in urban regions where the drainage system is frequently unable to handle a significant amount of water in such a short duration. Meanwhile, standard flood detection results are inaccurate for complex phenomena and cannot handle enormous quantities of data. In order to overcome those drawbacks and enhance the outcomes of conventional flood detection...
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Quinoline-based thiazolyl-hydrazones target cancer cells through autophagy inhibition
PublikacjaHeterocyclic pharmacophores such as thiazole and quinoline rings have a significant role in medicinal chemistry. They are considered privileged structures since they constitute several Food and Drug Administration (FDA)-approved drugs for cancer treatment. Herein, we report the synthesis, in silico evaluation of the ADMET profiles, and in vitro investigation of the anticancer activity of a series of novel thiazolyl-hydrazones based...
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Syntetyczne wskaźniki oceny stanu toru
PublikacjaJakość geometryczna toru analizowana jest w różnych celach, a dane podlegają różnemu stopniowi agregacji. Pojedyncze nierówności toru analizowane są zazwyczaj z uwagi na bezpieczeństwo i służą do planowanie napraw w krótkich terminach. Natomiast agregacja pomierzonych parametrów pozwala na planowanie robót w terminach średniookresowych i budowę modeli predykcji. W artykule przedstawiono zagregowane wskaźniki jakości geometrycznej...
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A Data Driven Model for Predicting RNA-Protein Interactions based on Gradient Boosting Machine
PublikacjaRNA protein interactions (RPI) play a pivotal role in the regulation of various biological processes. Experimental validation of RPI has been time-consuming, paving the way for computational prediction methods. The major limiting factor of these methods has been the accuracy and confidence of the predictions, and our in-house experiments show that they fail to accurately predict RPI involving short RNA sequences such as TERRA RNA....
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Cost assessment of computer security activities
PublikacjaComprehensive cost-benefit analysis plays a crucial role in the decision-making process when it comes to investments in information security solutions. The cost of breaches needs to be analysed in the context of spending on protection measures. However, no methods exist that facilitate the quick and rough prediction of true expenditures on security protection systems. Rafal Leszczyna of Gdansk University of Technology presents...
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The Concept of Geodetic Analyses of the Measurement Results Obtained by Hydrostatic Leveling
PublikacjaThe article discusses the issue of hydrostatic leveling. Its application is presented in structural health monitoring systems in order to determine vertical displacements of controlled points. Moreover, the article includes a complete computation scheme that utilizes the estimation from observation differences, allowing the elimination of the influence of individual sensors’ systematic errors. The authors suggest two concepts of...
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Non-Contact Temperature Measurements Dataset
PublikacjaThe dataset titled The influence of the distance of the pyrometer from the surface of the radiating object on the accuracy of measurements contains temperature measurements using a selection of four commercially available pyrometers (CHY 314P, TM-F03B, TFA 31.1125 and AB-8855) as a function of the measuring distance. The dataset allows a comparison of the accuracy and measuring precision of the devices, which are very important...
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Dynamic fracture of brittle shells in a space-time adaptive isogeometric phase field framework
PublikacjaPhase field models for fracture prediction gained popularity as the formulation does not require the specification of ad-hoc criteria and no discontinuities are inserted in the body. This work focuses on dynamic crack evolution of brittle shell structures considering large deformations. The energy contributions from in-plane and out-of-plane deformations are separately split into tensile and compressive components and the resulting...
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The Analysis of Patients' Airflow with Respect to Early Detection of Sleep Apnea
PublikacjaThe paper discusses the analysis of the respiratory events of sleep apnea patients. The analysis was carried out on the basis of the patient's airflow. As a result of the conducted analysis we proposed an algorithm which establishes an individual respiratory pattern for each subject. The algorithm could be implemented in the measurement - control system which manages the prosthetic device applying positive airway pressure. Its...
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New approach to railway noise modeling employing Genetic Algorithms
PublikacjaMain goal of this paper was to describe an innovative method of noise prediction based on Genetic Algorithms. First part of the paper addresses the problem of growing noise, mainly in the context of a unified method for measuring noise. Further, Genetic Algorithms are described with regards to their fundamental features. Further a description is provided as to how Genetic Algorithms were used in the area of noise modeling. Next...
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Application of Majority Voting Protocols to Supporting Trading Decisions
PublikacjaA broad spectrum of analysis and prediction indicators and methods exists to support trading decisions, but no hard knowledge exist to tell in advance which of them will fit best in a given timeframe. To support trading decisions, a multi-agent self-organizing system has been proposed. The system is based on history based dynamic weight voting and selects the right indicators based on their past performance. The formal analysis...
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APPLICATION OF MAJORITY VOTING PROTOCOLS TO SUPPORTING TRADING DECISIONS
PublikacjaA broad spectrum of analysis and prediction indicators and methods exists to support trading decisions, but no hard knowledge exist to tell in advance which of them will fit best in a given timeframe. To support trading decisions, a multi-agent self-organizing system has been proposed. The system is based on history based dynamic weight voting and selects the right indicators based on their past performance. The formal analysis...
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New type T-Source inverter
PublikacjaThis paper presents different topologies of voltage inverters with alternative input LC networks. The basic topology is known in the literature as a Z-source inverter (ZSI). Alternative passive networks were named by the authors as T-sources. T-source inverter has fewer reactive components in comparison to conventional Z-source inverter. The most significant advantage of the T-source inverter (TSI) is its use of a common voltage...
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T cell Activation Is Driven by an ADP-Dependent Glukosinase Linking Enhanced Glycolysis with Mitochondrial Reactive Oxygen Species Generation
PublikacjaMitochondria-originating reactive oxygen species control T cell receptor (TCR)-induced gene expression. Here, we show that TCR-triggered activation of ADP-dependent glucokinase (ADPGK), an alternative, glycolytic enzyme typical for Archaea, mediates generation of the oxidative signal. We also show that ADPGK is localized in the endoplasmic reticulum and suggest that its active site protrudes toward the cytosol. The ADPGK-driven...
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Versatility of putative aromatic aminotransferases from Candida albicans.
PublikacjaAmino acids constitute the key sources of nitrogen for growth of Candida albicans. In order to survive inside the host in different and rapidly changing environments, this fungus must be able to adapt via its expression of genes for amino acid metabolism. We analysed the ARO8, ARO9, YER152C, and BNA3 genes with regards to their role in the nutritional flexibility of C. albicans. CaAro8p is undoubtedly the most versatile enzyme...
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Verification of the new viscoelastic method of thermal stress calculation in asphalt layers of pavements
PublikacjaThe new viscoelastic method of thermal stress calculations in asphalt layers has been developed and published recently by the author. This paper presents verification of this method. The verification is based on the comparison of the results of calculations with results of testing of thermal stresses in Thermal Stress Restrained Specimen Test. The calculations of thermal stresses according to the new method were based on rheological...
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Explainable machine learning for diffraction patterns
PublikacjaSerial crystallography experiments at X-ray free-electron laser facilities produce massive amounts of data but only a fraction of these data are useful for downstream analysis. Thus, it is essential to differentiate between acceptable and unacceptable data, generally known as ‘hit’ and ‘miss’, respectively. Image classification methods from artificial intelligence, or more specifically convolutional neural networks (CNNs), classify...
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COVID‐19: A systematic review and update on prevention, diagnosis, and treatment
PublikacjaSince the rapid onset of the COVID-19 or SARS-CoV-2 pandemic in the world in 2019, extensive studies have been conducted to unveil the behavior and emission pattern of the virus in order to determine the best ways to diagnosis of virus and thereof formulate effective drugs or vaccines to combat the disease. The emergence of novel diagnostic and therapeutic techniques considering the multiplicity of reports from one side and contradictions...
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Protokół głosowania większościowego w narzędziu wsparcia decyzji handlowych
PublikacjaIstnieje szerokie spektrum narzędzi i metod wspierających decyzje handlowe, lecz brakuj jasnych reguł ich stosowania. Zaproponowano samoorganizujacy się system agentowy do wspierania decyzji handlowych. System bazując na glosowaniu z dynamicznymi wagami, wskazuje efektywne indykatory na podstawie ich poprzednich osiągnięć. Przedstawiono analizę formalną i wyniki weryfikacji, potwierdzającej cechy rozwiązania.
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New results on estimation bandwidth adaptation
PublikacjaThe problem of identification of a nonstationary autoregressive signal using non-causal estimation schemes is considered. Noncausal estimators can be used in applications that are not time-critical, i.e., do not require real-time processing. A new adaptive estimation bandwidth selection rule based on evaluation of pseudoprediction errors is proposed, allowing one to adjust tracking characteristics of noncausal estimators to unknown...
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Full scale measurements of pressure field induced on the quay wall by bow thrusters – indirect method for seabed velocities monitoring
PublikacjaThe paper presents the results of full-scale experimental investigation of loads generated on the quay wall by bow thrusters during unberthing of a self-manoeuvring vessel. The presented research allowed for the comparison of the measurements results with generally accepted empirical prediction methods and confirmed the utility of the developed measuring setup for the on-line monitoring of jet induced loads. The conclusions from the...
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Sensorless predictive control of three-phase parallel active filter
PublikacjaThe paper presents the control system of parallel active power filter (APF) with predictive reference current calculation and model based predictive current control. The novel estimator and predictor of grid emf is proposed for AC voltage sensorless operation of APF, regardless of distortion of this voltage. Proposed control system provides control of APF current with high precision and dynamics limited only by filter circuit parameters....
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A predictive estimation based control strategy for a quasi-resonant dc-link inverter
PublikacjaIn this paper the predictive estimation based control strategy for a quasi-resonant dc link inverter (PQRDCLI) is developed. Instead of direct measurement of dc link input inverter current – its estimation with one step prediction is applied. The PQRDCLI fed induction motor, controlled with a predictive current estimation stabilized inverter output voltage slopes independently of load. Moreover, reduction of overvoltage spikes...
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Ship Dynamic Positioning Based on Nonlinear Model Predictive Control
PublikacjaThe presented work explores the simulation test results of using nonlinear model predictive control algorithm for ship dynamic positioning. In the optimization task, a goal function with a penalty was proposed with a variable prediction step. The results of the proposed control algorithm were compared with backstepping and PID. The effect of estimation accuracy on the control quality with the implemented algorithms was investigated....
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FEM modelling of screw displacement pile interaction with subsoil
PublikacjaPredicting the-settlement characteristics of piles is an important element in the designing of pile foundations. The most reliable method in evaluating pile-soil interaction is the static load test, preferably performed with instrumentation for measuring shaft and pile base resistances. This, however, is a mostly post-implementation test. In the design phase, prediction methods are needed, in which numerical simulations play an...
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Biosynthetic and synthetic access to amino sugars.
PublikacjaAmino sugars are important constituents of a number of biomacromolecules and products of mi crobial secondary metabolism, including antibiotics. For most of them, the amino group is located at the positions C1, C2 or C3 of the hexose or pentose ring. In biological systems, amino sugars are formed due to the catalytic activity of specific aminotransferases or amidotransferases by introducing an amino functionality derived from L-glutamate...
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Removal of cyclohexane and ethanol from air in biotrickling filters inoculated with Candida albicans and Candida subhashii
PublikacjaThis paper presents investigations on the removal of cyclohexane and ethanol from air in polyurethane- -packed biotrickling filters, inoculated with Candida albicans and Candida subhashii fungal species. Results on process performance together with flow cytometry analyses of the biofilm formed over packing elements are presented and discussed. The results indicate that the presence of ethanol enhances the removal efficiency of cyclohexane...
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Biochemical, Structural Analysis, and Docking Studies of Spiropyrazoline Derivatives
PublikacjaIn this study, we evaluated the antiproliferative potential, DNA damage, crystal struc‐ tures, and docking calculation of two spiropyrazoline derivatives. The main focus of the research was to evaluate the antiproliferative potential of synthesized compounds towards eight cancer cell lines. Compound I demonstrated promising antiproliferative properties, especially toward the HL60 cell line, for which IC50 was equal to 9.4 μM/L....
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Determination of long-chain aldehydes using a novel quartz crystal microbalance sensor based on a biomimetic peptide
PublikacjaThere is an increasingly popular trend aimed at improvement of fundamental metrological parameters of sensors via implementation of materials mimicking biological olfactory systems. This study presents investigation on usefulness of the peptide mimicking HarmOBP7 region as a receptor element of the piezoelectric sensor for selective analysis of long-chain aldehydes. Identification of odorant binding proteins creates new possibilities...
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Simplified AutoDock force field for hydrated binding sites
Publikacjahas been extracted from the Protein Data Bank and used to test and recalibrate AutoDock force field. Since for some binding sites water molecules are crucial for bridging the receptor-ligand interactions, they have to be included in the analysis. To simplify the process of incorporating water molecules into the binding sites and make it less ambiguous, new simple water model was created. After recalibration of the force field on...
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Recovering Sound Produced by Wind Turbine Structures Employing Video Motion Magnification
PublikacjaThe recordings were made with a fast video camera and with a microphone. Using fast cameras allowed for observation of the micro vibrations of the object structure. Motion-magnified video recordings of wind turbines on a wind farm were made for the purpose of building a damage prediction system. An idea was to use video to recover sound & vibrations in order to obtain a contactless diagnostic method for wind turbines. The recovered signals...
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Residence time distribution in rapid multiphase reactors
PublikacjaResidence time distribution (RTD) provides information about average hydraulic residence time and the distribution of material in the reactor. A method for determining RTD for reactors with very short hydraulic residence times is deconvolution based on extraction of real RTD by the analysis of a non-ideal input signal. The mean residence time and dispersion were determined for the spinning fluids reactor (SFR). For the first time...
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Numerical modelling and experimental verification of compressible squeeze film pressure
PublikacjaThe validity of using the Reynolds equation for compressible squeeze film pressure was tested with computational fluid dynamics (CFD). A squeeze film air bearing was instrumented with pressure sensors and non-contacting displacement probes to provide transient measurements of film thickness and pressure. The film thickness measurements also provided input parameters to the numerical prediction. However, numerical results showed...
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Lattice filter based autoregressive spectrum estimation with joint model order and estimation bandwidth adaptation
PublikacjaThe problem of parametric, autoregressive model based estimation of a time-varying spectral density function of a nonstationary process is considered. It is shown that estimation results can be considerably improved if identification of the autoregressive model is carried out using the two-sided doubly exponentially weighted lattice algorithm which combines results yielded by two one-sided lattice algorithms running forward in...
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On autoregressive spectrum estimation using the model averaging technique
PublikacjaThe problem of estimating spectral density of a nonstationary process satisfying local stationarity conditions is considered. The proposed solution is a two step procedure based on local autoregressive (AR) modeling. In the first step Bayesian-like averaging of AR models, differing in order, is performed. The main contribution of the paper is development of a new final-prediction-error-like statistic, which can be used to select...
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Progressive failure analysis of laminates in the framework of 6-field nonlinear shell theory
PublikacjaThe paper presents the model of progressive failure analysis of laminates incorporated into the 6-field non-linear shell theory with non-symmetrical strain measures of Cosserat type. Such a theory is specially recommended in the analysis of shells with intersections due to its specific kinematics including the so-called drilling rotation. As a consequence of asymmetry of strain measures, modified laminates failure criteria must...
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Modeling of Performance, Reliability and Energy Efficiency in Large-Scale Computational Environment
PublikacjaLarge scale of complexity of distributed computational systems imposes special challanges for prediction of quality in such systems.Existing quality models for lower-scale systems include functionality,performance,reliability,flexibility and usability.Among these attributes,performance and reliability have a particular significance to the large-scale systems computing quality modeling due to their strong dependence on the system...
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Numerical investigations on early indicators of fracture in concrete at meso-scale.
PublikacjaFracture is a major reason of the global failure of concretes. The understanding of fracture is important to ensure the safety of structures and to optimize the material behaviour. In particular an early prediction possibility of fracture in concretes is of major importance. In this paper, concrete fracture under bending was numerically analysed using the Discrete Element Method (DEM). The real mesoscopic structure of a concrete...