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Search results for: active pharmaceutical ingredients
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Excitation of Non-Wave Modes by Sound of Arbitrary Frequency in a Chemically Reacting Gas
PublicationThe nonlinear phenomena in the field of high intensity sound propagating in a gas with a chemical reaction, are considered. A chemical reaction of A → B type is followed by dispersion and attenuation of sound which may be atypical during irreversible thermodynamic processes under some conditions. The first and second order derivatives of heat produced in the chemical reaction evaluated at the equilibrium temperature, density and...
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Molecular Umbrella as A Nanocarrier for Antifungals
PublicationA molecular umbrella composed of two O‐sulfated cholic acid residues was applied for the construction of conjugates with cispentacin, containing a “trimethyl lock” (TML) or o‐dithiobenzylcarbamoyl moiety as a cleavable linker. Three out of five conjugates demonstrated antifungal in vitro activity against C. albicans and C. glabrata but not against C. krusei, with MIC90 values in the 0.22–0.99 mM range and were not hemolytic. Antifungal...
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Introduction to the special issue on machine learning in acoustics
PublicationWhen we started our Call for Papers for a Special Issue on “Machine Learning in Acoustics” in the Journal of the Acoustical Society of America, our ambition was to invite papers in which machine learning was applied to all acoustics areas. They were listed, but not limited to, as follows: • Music and synthesis analysis • Music sentiment analysis • Music perception • Intelligent music recognition • Musical source separation • Singing...
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Synthetic strategies in construction of organic low molecular-weight carrier-drug conjugates
PublicationInefficient transportation of polar metabolic inhibitors through cell membranes of eukaryotic and prokaryotic cells precludes their direct use as drug candidates in chemotherapy. One of the possible solutions to this problem is application of the ‘Trojan horse’ strategy, i.e. conjugation of an active substance with a molecular carrier of organic or inorganic nature, facilitating membrane penetration. In this work, the synthetic...
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Modified Preisach model of hysteresis in multi air gap ferrite core medium frequency transformer
PublicationThis article presents the modified Preisach model of hysteresis for a 3-phase medium frequency transformer in a 100 kW dual active bridge converter. The transformer magnetic core is assembled out of ferrite I-cores, which results in multiple parasitic air gaps. For this transformer, the hysteresis loops were measured and parameters of the Preisach model were determined. The Preisach distribution function is approximated with a...
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Electrochemical behavior of a composite material containing 3D-structured diatom biosilica
Publication3D-structured diatom biosilica mixed with conducting carbon black was investigated as an active electrode material for lithium-ion batteries. Diatom biosilica was obtained by cultivation of the selected diatom species under laboratory conditions. Several instrumental techniques (XRD, FTIR, Raman, SEM-EDX, TGA) were used to characterize the physicochemical properties of applied biosilica. It was evidenced that the prepared new composite...
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Instantaneous Heating and Cooling Caused by Periodic or Aperiodic Sound of Any Characteristic Duration in a Gas with Vibrational Relaxation
PublicationThermodynamic relaxation of internal degrees of a molecule's freedom in a gas occurs with some characteristic time. This makes wave processes in a gas behave differently depending on the ratio of characteristic duration of perturbations and the relaxation time. In particular, generation of the secondary non-wave modes by intense sound in a nonlinear flow dependens on frequency. These kinds of interaction are considered in this...
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Labour resources in Azerbeijan
PublicationThe article aims to assess the changes of the Azerbaijani labour resources through deductive analysis of historical data and observation of changes in the structure of resources based on generally available macroeconomic data. Analysis shows that, during the period considered, the population of Azerbaijan increased, with a majority living in cities. Universal access to education enabled a growing group of Azerbaijanis to complete...
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The Practice of Dyadic Interviewing: Strengths, Limitations and Key Decisions
PublicationDyadic interviews, in which two participants are interviewed together, are becoming more popular in qualitative research, but are much less discussed in the methodological literature than individual and group forms. In this article, we consider the nature and value of dyadic interviews, recognizing them as active, relational encounters, shaped by what all parties bring to them, and infused with issues of power. Drawing on our research...
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Spatial distribution of pharmaceuticals in conventional wastewater treatment plant with Sludge Treatment Reed Beds technology
PublicationPharmaceutical residues are an emerging environmental problem. It is strongly confirmed that pharmaceuticals are present in soils and environmental waters (surface, marine and even groundwater), and that wastewater treatment plant (WWTP) effluents are the main source of pharmaceuticals in the watershed. The aim of this studywas to recognize the spatial distribution and seasonal changes of selected pharmaceuticals in conventional WWTP...
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Przedsiębiorcy 55+, czy wiek ma znaczenie?
PublicationZnaczenie przedsiębiorczości 55+ w ostatnim okresie rośnie, między innymi w związku ze zmianami demograficznymi i starzeniem się społeczeństwa w większości krajów europejskich. Nie bez znaczenia jest także fakt, że starsi ludzie zaczynają wierzyć, że mogą uczestniczyć w rynku pracy, zarówno po stronie zatrudnianych jak i zatrudniających. Stąd też liczba nowych firm, tworzonych przez osoby starsze wzrasta, a starsi właściciele firm...
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Synthesis Methods and Favorable Conditions for Spherical Vaterite Precipitation: A Review
PublicationVaterite is the least thermodynamically stable anhydrous calcium carbonate polymorph. It exists very rare in nature, e.g. in some rock formations or as a component of biominerals produced by some fishes, crustaceans or birds. Synthetic vaterite particles are proposed as carriers of active substances in medicines, additive in cosmetic preparations as well as adsorbents. Also, their utilization as a pump for microfluidic flow is...
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Synthesis and biological evaluation of N-acylated tyramine sulfamates containing C-F bonds as steroid sulfatase inhibitors
PublicationSteroid sulfatase (STS) is responsible for the hydrolysis of biologically inactive sulfated steroids into their active un-sulfated forms and promotes the growth of various hormone-dependent cancers (e.g., breast cancer). Therefore, the STS enzyme is a promising therapeutic target for the treatment of steroid-sensitive cancers. Herein, we report the synthesis and biological evaluation of sulfamate analogs as potential STS inhibitors...
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State-of-the-art ideas for engineering laboratory classes – virtual reality framework
PublicationNowadays challenges in science and technology are a driving force in the development of contemporary solutions in education. Virtual reality brings to an edge human imagination. In this paper, authors propose a framework for civil engineering laboratory classes which brings a new quality in this area. The framework shows how to provide learners with an environment where they can realize the health and safety hazards of construction...
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Non-metaldoped TiO2 nanotube arrays for high efficiency photocatalytic decomposition of organic species in water
PublicationTitanium dioxide is a well-known photoactive semiconductor with a variety of possible applications. The procedure of pollutant degradation is mainly performed using TiO2 powder suspension. It can also be exploited an immobilized catalyst on a solid support. Morphology and chemical doping have a great influence on TiO2 activity under illumination. Here we compare photoactivity of titania nanotube arrays doped with non-metal atoms:...
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Optical monitoring of electrochemical processes with ITO-based lossy-mode resonance optical fiber sensor applied as an electrode
PublicationIn this work we discuss the application of optical fiber sensors based on lossy-mode resonance (LMR) phenomenon for real-time optical monitoring of electrochemical processes. The sensors were obtained by a reactive high power impulse magnetron sputtering of indium tin oxide (ITO) on a 2.5 cm-long core of polymer-clad silica fibers. The LMR effect made monitoring of changes in optical properties of both ITO and its surrounding medium...
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Arbutin: Isolation, X-ray structure and computional studies
PublicationArbutin, an active component originated from Serratula quinquefolia for skin-whitening use and treating skin related allergic inflammation, was characterized by microanalysis, FTIR, UV-Vis, multinuclear NMR spectroscopy, and single crystal X-ray diffraction method. The geometries of the studied compound were optimized in singlet states using the density functional theory (DFT) method with B3LYP functional. Electronic spectra were...
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Application of the chromatographic retention index system for the estimation of the calibration constants of permeation passive samplers with polydimethylsiloxane membranes
PublicationThe paper presents the results of research on the calibration of permeation passive samplers equipped with polydimethylsiloxane (PDMS) membranes using the physico-chemical properties of the analytes. Strong correlations were found between the calibration constants of the samplers and the linear temperature-programmed retention indices of the analytes determined on columns coated with pure PDMS (r2 = 0.914). These correlations...
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Power control system structure of doubly‐fed induction generator connected to current source converter
PublicationThe power control system structures for a doubly-fed generator (DFIG) are proposed. The classical field oriented control and the feedback control with the multi-scalar variables were considered. The generator is working in the AC grid connection mode. The rotor side of the generator is connected to the current source converter (CSC); the stator is directly related to the AC grid. The static feedback linearization using the multi-scalar...
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Grafting and reactive extrusion technologies for compatibilization of ground tyre rubber composites: Compounding, properties, and applications
PublicationChemical modification of ground tyre rubber (GTR) to compatibilize it with the matrix is a well-known approach. Based on our recent review of the surface etching methods used in GTR modification, the purpose of the current work is to take a deeper look into more advanced methods such as grafting and reactive extrusion. While grafting is more efficient in achieving compatibility, however, it usually involves multi-step synthesis...
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Single-phase, Five-level Inverter with SPWM-Based Neutral Point Voltage Balancing Scheme
PublicationMultilevel inverter topologies provide several advantages over two-level inverter configuration. These benefits are the reason for the growing interest in multilevel topologies among research society. One of the most popular topological concepts (diode and active switch clamping) requires neutral-point potential balancing due to series-connected capacitor banks across the input dc link in such derived inverter configurations. This...
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Low cost microwave X-band generator
PublicationA low cost microwave X-band generator for educational purposes was designed and built. Its simple construction and user's interface makes it suitable for a student laboratory.The generator is based on a single frequency conversion concept. It uses a digitally tunable PLL chip for intermediate frequency generation and an active frequency multiplier for frequency conversion. The generator covers 9,7 - 11 GHz part of the X frequency...
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Highly linear CMOS triode transconductor for VHF applications
PublicationA high-speed, fully balanced complementary-symmetry metal-oxide-semiconductor (CMOS) triode transconductor is presented. The proposed approach exploits a pseudo-differential-pair triode configuration with a simple adaptive circuit stabilising the drain-to-source voltages of metal-oxide-semiconductor (MOS) transistors. Since no additional active circuits (apart from the resistors made of the cut-off MOS devices) and no feedback...
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Determination of chemical oxygen demand (cod) at boron-doped diamond (bdd) sensor by means of amperometric technique
PublicationA boron-doped diamond (BDD) sensor was proposed for effective detection of chemical oxygen demand (COD) by means of amperometric technique. Thin boron doped diamond active sensor layer was deposited on Si wafer and glassy carbon substrate by Microwave Plasma Enhanced Chemical Vapor Deposition (MW PE CVD). The structure of BDD was confirmed by Raman spectra analysis. Broad Raman bands centered at 482 cm-1 and 1219 cm-1 are typical...
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Determination of Chemical Oxygen Demand (COD) at Boron-doped Diamond (BDD) Sensor by Means of Amperometric Technique
PublicationA boron-doped diamond (BDD) sensor was proposed for effective detection of chemical oxygen demand (COD) by means of amperometric technique. Thin boron doped diamond active sensor layer was deposited on Si wafer and glassy carbon substrate by Microwave Plasma Enhanced Chemical Vapor Deposition (MW PE CVD). The structure of BDD was confirmed by Raman spectra analysis. Broad Raman bands centered at 482 cm-1 and 1219 cm-1 are typical...
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A new diagnostic method for evaluation of cardiosurgery wound healing
PublicationOne of important and still unsolved problems in medicine is the question of objective and quantitative evaluation of post-surgery wound healing. The aim of this research is to analyse possibility and value of using the newly elaborated infrared imaging procedure – Active Dynamic Thermography (ADT) – for quantitative description of wound healing processes in cardiosurgery. Both, classical thermal figures of merit as well as ADT...
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Unconventional and user-friendly sampling techniques of semi-volatile organic compounds present in an indoor environment: An approach to human exposure assessment
PublicationThe commonly applied solutions used to assess the potential risk of human exposure to semi-volatile organic compounds (SVOCs) are based on the investigation of biological samples collected in an invasive or non-invasive manner. For SVOCs, which are typically introduced to humans through the respiratory system, dermal adsorption, or digestive system, sampling solutions generally used in the indoor environments are classified as...
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Power Electronics Building Blocks for implementing Smart MV/LV Distribution Transformers for Smart Grid
PublicationWith an observed increase in the involvement of active consumers in activities aimed at improving energy efficiency and increasing interest in producing energy from renewable sources, there is a need for the development of new technologies enabling the distribution network operators to offer new services and functionalities. Smart MV/LV distribution transformers are characterized by a compact three-stage design, including an...
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Electrochemical and photoelectrochemical characterization of photoanodes based on titania nanotubes modified by a BiVO4 thin film and gold nanoparticles
PublicationTitania nanotubes (TNT) modified with thin films of bismuth vanadate (BiVO4) and gold nanoparticles (GNP) were photoelectrochemically characterized as photoanodes for water photooxidation. Presence of bismuth vanadate enhanced efficiency of photocurrent generation in comparison with pristine TNTs under visible light illumination. Besides an extended range of absorbed light, the presence of both BiVO4 and GNP reduced the charge...
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Experiment with small objects floating under water in the harbor security aspect.
PublicationObservation of the underwater area is the element of general trend which primary purpose is to protect and enhance the safety of the selected region. The aim of the paper is to present the acoustic characteristics of typical objects floating on the surface or under the water, which constitute some knowledge on how to detect these objects. Create a catalog of acoustic signatures and acoustic images of objects mostly floating under...
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Metal (Mo, W, Ti) Carbide Catalysts: Synthesis and Application as Alternative Catalysts for Dry Reforming of Hydrocarbons—A Review
PublicationDry reforming of hydrocarbons (DRH) is a pro-environmental method for syngas production. It owes its pro-environmental character to the use of carbon dioxide, which is one of the main greenhouse gases. Currently used nickel catalysts on oxide supports suffer from rapid deactivation due to sintering of active metal particles or the deposition of carbon deposits blocking the flow of gases through the reaction tube. In this view,...
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Effect of convection and microwave heating on the retention of bioactive components in human milk
PublicationBioactive substances are very important components of human milk (HM), especially for premature newborns. The effects of convection (CH) and microwave heating (MWH) at 62.5 and 66 °C, on the level of selected bioactive components of HM: lysozyme (LZ), lactoferrin (LF), secretory immunoglobulin A (sIgA), basal lipase (BL), cytokine TGF-2, vitamin C and total antioxidant capacity (TAC) was compared. Regardless of the used heating methods...
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A dual-control strategy based on electrode material and electrolyte optimization to construct an asymmetric supercapacitor with high energy density
PublicationMetal-organic frames (MOFs) are regarded as excellent candidates for supercapacitors that have attracted much attention because of their diversity, adjustability and porosity. However, both poor structural stability in aqueous alkaline electrolytes and the low electrical conductivity of MOF materials constrain their practical implementation in supercapacitors. In this study, bimetallic CoNi-MOF were synthesized to enhance the electrical...
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SiC-based T-type modules for multi-pulse inverter with coupled inductors
PublicationThe paper presents SiC-based three-level T-type modules designed for a high-performance 30kVA DC/AC inverter operating at high frequency 85 kHz with low THD of the output voltage. This inverter system consists of two integrated parts. The first part is active and contains three parallelconnected three-phase T-type modules built with fast-switching SiC power transistors. The second, passive part of the system is a set of inductors...
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Assessing the Risk in Urban Public Transport for Epidemiologic Factors
PublicationPandemics have presented new challenges for public transport organisers and operators. New diseases (e.g., influenza H1N1, severe acute respiratory syndrome—SARS, as well as, more recently, SARS-CoV-2) increase the need for new protection measures to prevent epidemic outbreaks in public transport infrastructure. The authors’ goal is to present a set of actions in the area of public transport that are adjusted to different levels...
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Folding‐upon‐repair DNA nanoswitches for monitoring DNA repair enzymes activity
PublicationWe demonstrate here a new class of DNA‐based nanoswitches that, upon enzymatic repair, could undergo a conformational change mechanism leading to a change in fluorescent signal. Such folding‐upon‐repair DNA nanoswitches are synthetic DNA sequences containing O6‐methyl‐guanine (O6‐MeG) nucleobases and labelled with a fluorophore/quencher optical pair. The nanoswitches are rationally designed so that only upon enzymatic demethylation...
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Determination of thiocyanate as a biomarker of tobacco smoke constituents in selected biological materials of human origin
Publicationn order to protect human health, it is necessary to biomonitor toxic substances originating from tobacco smoke in biological materials sampled from persons with different exposures to tobacco smoke constituents. Thiocyanate anion is a biomarker of exposure to tobacco smoke components which is characterized by a relatively long half‐life in the human body, i.e. 6 days. In this work, we present the results of thiocyanate determinations...
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Difference in Perceived Speech Signal Quality Assessment Among Monolingual and Bilingual Teenage Students
PublicationThe user perceived quality is a mixture of factors, including the background of an individual. The process of auditory perception is discussed in a wide variety of fields, ranging from engineering to medicine. Many studies examine the difference between musicians and non-musicians. Since musical training develops musical hearing and other various auditory capabilities, similar enhancements should be observable in case of bilingual...
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Inhibitors of glucosamine-6-phosphate synthase as potential antimicrobials or antidiabetics – synthesis and properties
PublicationGlucosamine-6-phosphate synthase (GlcN-6-P synthase) is known as a promising target for antimicrobial agents and antidiabetics. Several compounds of natural or synthetic origin have been identified as inhibitors of this enzyme. This set comprises highly selective L-glutamine, amino sugar phosphate or transition state intermediate cis-enolamine analogues. Relatively low antimicrobial activity of these inhibitors, poorly penetrating...
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Managing change through team building in the context of organizing Erasmus+ mobility projects at the Gdańsk Tech Library
PublicationThe article discusses managing change through team building in the context of organizing Erasmus+ mobility projects in the Gdańsk University of Technology Library as the main strategy which contributed to the projects’ success. The authors describe the projects realized in the years 2017-2019 within the scope of the Erasmus+ programme. The organizers decided to take a responsible and active approach towards managing change and...
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Nutritional Characterization of Whole Mangosteen Pulp with Seeds and Its Application as an Alternate Functional Ingredient in Crackers
PublicationMangosteen (Garcinia mangostana L.) fruits are high in nutrients and phytochemical compounds. The use of fresh whole mangosteen fruit pulp, including the seeds (MFS), instead of flour and sugar in crackers not only enhances the functional nutritional and medicinal benefits for consumers but also adds value to the products. The study investigated the nutritional value of MFS and then employed MFS to formulate MFS-based crackers...
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Analysis of the influence of polystyrene microplastics and their derivatives on the DNA of human colon epithelial cells HT29 with the comet assay
PublicationWe have been using plastic for almost a century and nowadays a lot of them circulates as pollutants in the environment and still defragmenting to micro and nanoscale. The exposition through the food chain and its precise impact on human health is still not clear. In our study, we tested real food packaging after contact with food products and real thermoinsulation and environmental samples of polystyrene in different model liquids,...
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Impact of inorganic ions and pH variations on toxicity and endocrine potential of selected environmentally relevant pharmaceuticals
PublicationAssessment of the impact of pharmaceutical residues on living organisms is a very complex subject. Apart from taking into account the toxicity of individual compounds, environmental factors should also be taken into account. In this paper, attempts were made to assess the impact of coexisting inorganic ions and changes in pH on the toxicity of ten selected pharmaceuticals. Two bioassays were used to measure the estrogenic and androgenic...
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Theory and application of Near-infrared spectroscopy
PublicationIn recent years one can observe a significant increase in the requirements on quality control in all industrial sectors. The growing number of involved analyses makes the traditional, time consuming, requiring use of large quantities of reagents, thus expansive methods inconvenient especially for industrial applications. Fortunately, there is a very fast, cheap and not invasive analytical method that is increasingly used in qualitative...
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Magnetically recyclable TiO2/MXene/MnFe2O4 photocatalyst for enhanced peroxymonosulphate-assisted photocatalytic degradation of carbamazepine and ibuprofen under simulated solar light
PublicationIn this study, a novel TiO2/Ti3C2/MnFe2O4 magnetic photocatalyst with dual properties, enabling (i) improved photocatalytic degradation with PMS activation under simulated solar light and (ii) magnetic separation after the degradation process in an external magnetic field was developed and applied for the efficient photodegradation pharmaceutically active compounds (PhACs) frequently present in wastewater and surface waters worldwide. MXene...
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Analysis of compressive forces in CFGFT cylindrical pillars and their coatings using laboratory tests and metric spaces
PublicationThe article discusses compressive forces tests in composite-concrete pillars with the use of laboratory active experiment including the factors and properties of materials which have a significant impact on the test results and their repeatability. A polymer composite based on glass fiber reinforced resin with different fiber beam angles (20, 55 and 85) was used as a buffer/coat of the pole. Due to the problems with direct comparison...
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SURFACTANTS IN KLODNICA RIVER (KATOWICE, POLAND). PART I. LINEAR ALKYLBENZENE SULPHONATES (LAS)
PublicationSurfactants are a group of compounds with specific physico-chemical properties and therefore they are used in many spheres of human activity. Surface-active substances undergo various physico-chemical transformations, what enables their migration between different elements of the environment and may lead to its pollution. Selected anionic surfactants were determined in samples of water from the Klodnica river (25 samples) and bottom...
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Biosilica from sea water diatoms algae—electrochemical impedance spectroscopy study
PublicationHere, we report on an electrochemical impedance study of silica of organic origin as an active electrode material. The electrode material obtained from carbonized marine biomass containing nanoporous diatoms has been characterised by means of XRD, IR, SEM and EIS. Dif- ferent kinds of crystallographic phases of silica as a result of thermal treatment have been found. The electrode is electrochemically stable during subsequent cyclic...
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Influence of reactive oxygen species during deposition of iron oxide films by high power impulse magnetron sputtering.
PublicationIron oxide films were deposited using high power impulse magnetron sputtering (HiPIMS) of an iron cathode in an argon/oxygen gas mixture at different gas pressures (0.5~Pa, 1.5~Pa, and 5.0~Pa). The HiPIMS system was operated at a repetition frequency $f = 100$~Hz with a duty cycle of 1~\%. A main goal is a comparison of film growth during conventional and electron cyclotron wave resonance-assisted HiPIMS. The deposition plasma...
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Frequency and time domain characteristics of digital control of electric vehicle in-wheel drives
PublicationIn-wheel electric drives are promising as actuators in active safety systems of electric and hybrid vehicles. This new function requires dedicated control algorithms, making it essential to deliver models that reflect better the wheel-torque control dynamics of electric drives. The timing of digital control events, whose importance is stressed in current research, still lacks an analytical description allowing for modeling its...