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Search results for: DRUGS DRUG RESEARCH PHARMACEUTICALS’ INTERACTION ECOTOXICITY ECOLOGY ●MICROTOX®
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Experimental study on the selected aspects of bow thruster generated flow field at ship zero-speed conditions
PublicationThe paper presents the results of experimental study on the interaction between the bow thrusters understood as the flow field changes generated by bow tunnel thruster in deep water conditions operated as a single and twin units. The research was limited to zero-speed case for the ship dead in the water. The influence of the hull form and jet spread between the neighbouring thrusters for several combinations of the applied bow...
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Stateczność i niezawodność pełnomorskich platform wiertniczych
PublicationW pracy przedstawiono wieloletnie doświadczenia Autora w zakresie wybranych aspektów numerycznej analizy pełnomorskich platform wiertniczych, w szczególności stacjonarnych platform stalowych poddanych działaniu fal wiatrowych i wiatru. W opisie zachowania się platform uwzględniono współoddziaływanie trzech ośrodków: materiału konstrukcji, morskich fal wiatrowych i podłoża gruntowego. Przyjęcie do opisu stochastycznych właściwości...
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Evaluation of Body Surface Area Formulae Based on 3D Body Scans
PublicationHuman body surface area (BSA) is an established parameter for the calculation of chemotherapy drugs dosage, treatment of chronic hepatitis B, treatment of burns or for establishing a dosing regimen for antimicrobials. Although being a critical parameter, usage of modern 3D scanners, which would measure the exact BSA value, is often impossible in time-sensitive operations or for patients unable to withstand the scanning process....
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Telomerase inhibition - unfulfilled hopes in the perfect molecular target
PublicationTelomerase plays a pivotal role in cell proliferation, homeostasis, and neoplastic transformation, making it a promising molecular target for cancer chemotherapy. Of note, although hTERT has been explored thoroughly as a target, none of the promising molecules has been approved as a drug until now. The subject of research conducted as part of my doctoral dissertation is explaining the cellular and molecular mechanism of action...
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Convolutional Neural Networks for C. Elegans Muscle Age Classification Using Only Self-Learned Features
PublicationNematodes Caenorhabditis elegans (C. elegans) have been used as model organisms in a wide variety of biological studies, especially those intended to obtain a better understanding of aging and age-associated diseases. This paper focuses on automating the analysis of C. elegans imagery to classify the muscle age of nematodes based on the known and well established IICBU dataset. Unlike many modern classification methods, the proposed...
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CaZnO-based nanoghosts for the detection of ssDNA, pCRISPR and recombinant SARS-CoV-2 spike antigen and targeted delivery of doxorubicin
PublicationOverexpression of proteins/antigens and other gene-related sequences in the bodies could lead to significant mutations and refractory diseases. Detection and identification of assorted trace concentrations of such proteins/antigens and/or gene-related sequences remain challenging, affecting different pathogens and making viruses stronger. Correspondingly, coronavirus (SARS-CoV-2) mutations/alterations and spread could lead to overexpression...
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Molecular basis and quantitative assessment of TRF1 and TRF2 protein interactions with TIN2 and Apollo peptides
PublicationShelterin is a six-protein complex (TRF1, TRF2, POT1, RAP1, TIN2, and TPP1) that also functions in smaller subsets in regulation and protection of human telomeres. Two closely related proteins, TRF1 and TRF2, make high-affinity contact directly with double-stranded telomeric DNA and serve as a molecular platform. Protein TIN2 binds to TRF1 and TRF2 dimer-forming domains, whereas Apollo makes interaction only with TRF2. To elucidate...
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Hybrid design approach in education using a progressive rule-based digital design development. Sopot College experiences.
PublicationBudynek sam w sobie może być uznany za hybrydę inżynierii i Beaux-Arts. Obecnie istnieje wiele narzędzi, które mogą pomóc architektom w opracowaniu i optymalizowu ich innowacyjnych koncepcje. Artykuł opisuje projekt hybrydowego podejścia opartego na połączeniu tradycyjnej architekturze i Komputerowego projektowania na podstawie programu studiów w Sopocie College, Wydział Architektury. Artykuł bada dziedzinie współpracy i interakcji...
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The lanthanide influence on selected properties of BaLnCo2O6-δ
PublicationThe subject of research of this dissertation are cobalt oxides with a double perovskite structure with a general formula BaLnCo2O6-δ, where Ln stands for La, Pr, Nd, Sm, Gd, Tb, Dy. The aim of the study was to verify the ability of these materials to form the protonic defects, as well as to identify the factors determining this ability. As part of the work, materials from the proposed group were synthesised and characterized. To...
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Polish Suburban Landscape made of Enterpereneurial Tissue
PublicationDwa ostatnie dekady w Polsce to okres ekspansywny rozwój małych przedsiębiorstw i równolegle dynamiczne przekształcenia przestrzeni wokół miasta . Rozwój tych dwóch zjawisk nastąpiło w okresie transformacji gospodarczej po 1989 roku . Głównym celem pracy jest zbadanie poziomu interakcji między procesem suburbanizacji i rozwojem sektora MSP w wybranych podmiejskich obszary, na przykładzie Metropolii Trójmiejskiej.
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Molecular Design Using Selected Concentration Effects in Optically Activated Fluorescent Matrices
PublicationMolecular physics plays a pivotal role in various fields, including medicine, pharmaceuticals, and broader industrial applications. This study aims to enhance the methods for producing specific optically active materials with distinct spectroscopic properties at the molecular level, which are crucial for these sectors, while prioritizing human safety in both production and application. Forensic science, a significant socio-economic...
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Hydrophobic (deep) eutectic solvents (HDESs) as extractants for removal of pollutants from water and wastewater – A review
PublicationDeep eutectic solvents (DESs) are a new generation of solvents that attracted increasing attention in diverse applications. In last years, growing number of studies on hydrophobic (deep) eutectic solvents (HDESs) as an alternative extractants for various chemicals from aqueous environments have been reported. This article provides an overview on the usage of HDESs in liquid–liquid extraction (LLE) of different pollutants from water...
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Targeting of FLT3-ITD kinase contributes to high selectivity of imidazoacridinone C-1311 against FLT3-activated leukemia cells
PublicationDrugs targeting receptor tyrosine kinase FLT3 are of particular interest since activating FLT3-internal tandem duplication (ITD) mutations abundantly occur in fatal acute myeloid leukemias (AMLs). Imidazoacridinone C-1311, a DNA-reactive inhibitor of topoisomerase II, has been previously shown to be a potent and selective inhibitor of recombinant FLT3. Here, we expand those findings by studying its effect on leukemia cells with...
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Mass spectrometry based identification of geometric isomers during metabolic stability study of a new cytotoxic sulfonamide derivatives supported by quantitative structure-retention relationships
PublicationA set of 15 new sulphonamide derivatives, presenting antitumor activity have been subjected to a metabolic stability study. The results showed that besides products of biotransformation, some additional peaks occurred in chromatograms. Tandem mass spectrometry revealed the same mass and fragmentation pathway, suggesting that geometric isomerization occurred. Thus, to support this hypothesis, quantitative structure-retention relationships...
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Prenatal exposure to substance of abuse: A worldwide problem
PublicationSubstance abuse during pregnancy is an important public health issue affecting the mother and the growing infant. Preterm labor, miscarriage, abruption and postpartum hemorrhage are obstetric complications which have been associated with women who are dependent on abused substances. Moreover, women are also at an increased risk of medical problems such as poor nutrition, anemia, urinary tract infections as well as sexually transmitted...
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A study on microcrack monitoring in concrete: discrete element method simulations of acoustic emission for non-destructive diagnostics
PublicationThe research is focused on the monitoring of fracture evolution in concrete beams under three-point bending using the acoustic emission technique and the discrete element method. The main objective of the study was to numerically and experimentally investigate the mechanism behind the generation of elastic waves during acoustic emission events and their interaction with micro- and macro-cracking in concrete beams under monotonic...
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A note on the affective computing systems and machines: a classification and appraisal
PublicationAffective computing (AfC) is a continuously growing multidisciplinary field, spanning areas from artificial intelligence, throughout engineering, psychology, education, cognitive science, to sociology. Therefore, many studies have been devoted to the aim of addressing numerous issues, regarding different facets of AfC solutions. However, there is a lack of classification of the AfC systems. This study aims to fill this gap by reviewing...
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Ligand-Modified Boron-Doped Diamond Surface: DFT Insights into the Electronic Properties of Biofunctionalization
PublicationWith the increasing power of computation systems, theoretical calculations provide a means for quick determination of material properties, laying out a research plan, and lowering material development costs. One of the most common is Density Functional Theory (DFT), which allows us to simulate the structure of chemical molecules or crystals and their interaction. In developing a new generation of biosensors, understanding the nature...
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Mechanical, thermo-mechanical properties of epoxy/glass composites with submicron particles
PublicationIn this research the influence of submicron zinc oxide and silicon dioxide particles on mechanical, thermo-mechanical properties of epoxy matrix composites reinforced with glass fibres was investigated. Composites were fabricated using hand lay-up method. Materials contained 39-41 wt.% of glass fibres. The bending tests, dynamic mechanical analysis and tribological tests were performed on each group of composites and also for...
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Detection of Objects Buried in the Sea Bottom with the Use of Parametric Echosounder
PublicationThe paper contains results of a in situ research main task of which was to detect objects buried, partially or completely, in the sea bottom. Object detecting technologies employing acoustic wave sources based on nonlinear interaction of elastic waves require application of parametric sound sources. Detection of objects buried in the sea bottom with the use of classic hydroacoustic devices such as the sidescan sonar or multibeam...
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A study of jet impingement cooling enhancement by concave and convex heat sink shape modifications
PublicationThe rising demand for efficient cooling technologies is a strong driver of extensive research in this area. This trend is particularly strong in turbines and microprocessors technology. Presented study is focused on the jet impingement cooling concept, which is used in various configurations for many years. The potential of the heat sink shape modification is not yet fully explored. Available literature suggests that average Nusselt...
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On the differential effect of temperature on the Nusselt-Rayleigh relationship in free convection
PublicationThe aim of and inspiration behind this paper was to explain the reasons, also observed by other researchers, of the discrepancy in the results of experimental free convection, which for small Rayleigh and Nusselt numbers in the initial phase of research can sometimes reach several hundred percent. These discrepancies decrease with increasing heating power and plate surface temperature, in proportion to the increase in Ra and Nu,...
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Usability Testing of Mobile Applications: A Methodological Framework
PublicationLess than five percent of all mobile applications have become successful throughout 2023. The success of a new mobile application depends on a variety of factors ranging from business understanding, customer value, and perceived quality of use. In this sense, the topic of usability testing of mobile applications is relevant from the point of view of user satisfaction and acceptance. However, the current knowledge seems to be fragmented,...
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Biofilm bakteryjny uropatogennych szczepów E. coli Dr+ jako czynnik indukujący przewlekłość zakażeń dróg moczowych ograniczający ich leczenie
PublicationZakażenia dróg moczowych (ZUM) stanowią jedne z najczęściej występujących infekcji bakteryjnych, dotykających każdego roku miliony osób na świecie. Problematyka tych zakażeń wynika z ich przewlekłości i nawrotów, pomimo stosowania terapii antybiotykowej oraz ciągle wzrastającej lekooporności uropatogenów je wywołujących. Dominującym czynnikiem etiologicznym ZUM są uropatogenne szczepy E. coli (UPECs), wykazujące zdolność do adhezji,...
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DIGITALIS DevelopInG dIgiTAL monitorIng System for optimal conservation efforts
ProjectsProject realized in Department of Metrology and Optoelectronics according to 000001620 agreement from 2022-05-05
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Reverberation divergence in VR applications
PublicationThe aim of this project was to investigate the correlation between virtual reality (VR) imagery and ambisonic sound. With the increasing popularity of VR applications, understanding how sound is perceived in virtual environments is crucial for enhancing the immersiveness of the experience. By examining the relationship between visual scenes and sound scenes, this research attempts to explore how the interaction between vision and...
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One Year Evaluation of Material Properties Changes of Polylactide Parts in Various Hydrolytic Degradation Conditions
PublicationBiodegradable biocompatible materials are widely used in medical applications. Determining the possibility of using biodegradable materials depends on determining the changes in their parameters over time due to degradation. The current scientific research on biodegradable materials has presented results based on research methods characterized by the different geometry and cross-section size of the specimen, type of degradation...
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Comparative molecular dynamics study of dimeric and monomeric forms of HIV-1 protease in ligand bound and unbound state
PublicationHuman immunodeficiency virus type 1 protease (HIV-1 PR) is a viral-encoded enzyme that forms a homodimer. HIV-1 PR is essential for replication and assembly of the virus and inactivation of HIV-1 PR enzyme causes production of immature, noninfectious viral particles and thus HIV-1 PR is an attractive target in anti-AIDS drug design. In our current work, we performed molecular dynamics (MD) calculations (500 ns) for two different...
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The value of less Light – Sustainable architectural lighting design
PublicationSince its beginning, the art of external illumination has substantially influ-enced the creation and the perception of architecture and the night-time urban environment. In her lecture, the author examines and defines the significant interdisciplinary conditions related to architectural lighting design that have evolved over the years, starting from the first simple exterior lighting projects to the more modern, complex concepts...
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Towards Rational Biosurfactant Design—Predicting Solubilization in Rhamnolipid Solutions
PublicationThe efficiency of micellar solubilization is dictated inter alia by the properties of the solubilizate, the type of surfactant, and environmental conditions of the process. We, therefore, hypothesized that using the descriptors of the aforementioned features we can predict the solubilization efficiency, expressed as molar solubilization ratio (MSR). In other words, we aimed at creating a model to find the optimal surfactant and...
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Antecedents and outcomes of social media fatigue
PublicationPurpose – This study aims to explore which of four chosen factors (i.e. privacy concerns, FoMO, self-disclosure and time cost) induce a feeling of strain among Facebook users in terms of social media fatigue (SMF), and if this occurs, whether it further influences such outcomes as discontinuance of usage (DoU) and interaction engagement decrement (IED). Design/methodology/approach – Through an online structured questionnaire, empirical...
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Comparison between measured and calculated underwater pressure of merchant ship
PublicationFrom 2012 The Polish Naval Academy take part in an international research project SIRAMIS, carried out in the framework of the European Defence Agency. The objective of this project is to improve the understanding of ship signature interaction with multi influence sensors in relevant and realistic scenario's. This paper describes selected results of the comparison results of sea trials and model calculations of the hydrodynamic...
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Space and spatial practices in times of confinement. Evidence from three European countries: Austria, France and Poland
PublicationIn the first half of 2020, millions of people were subjected to drastic restrictions aimed at limiting the spread of the Covid-19 disease. Austria, France and Poland have implemented a lockdown to varying degrees and for varying lengths of time. This is an unprecedented situation in Europe: until now, even in times of war, curfew measures have never been applied 24 h a day. The research presented in this article was carried out...
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Stability and load bearing capacity of a braced truss under upward wind loading
PublicationThe paper is focused on the numerical and experimental investigation of stability of a steel truss under upward wind loading. The structure was stiffened by elastic braces situated at the top and bottom chord. Usually the lateral (translational) brace stiffness is considered. However, the rotational stiffness of braces caused by interaction between torsional stiffness of the truss top chord and bending stiffness of the roof elements...
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Stability and load bearing capacity of a braced truss under upward wind loading
PublicationThe paper is focused on the numerical and experimental investigation of stability of a steel truss under upward wind loading. The structure was stiffened by elastic braces situated at the top and bottom chord. Usually the lateral (translational) brace stiffness is considered. However, the rotational stiffness of braces caused by interaction between torsional stiffness of the truss top chord and bending stiffness of the roof elements...
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Advanced Oxidation Processes for the Treatment of Contaminants of Emerging Concern
PublicationThe application of contaminants of emerging concern (CEC) such as pharmaceuticals and personal care products (PPCPs), pesticides, plasticizers, endocrine disruptors, surfactants, flame retardants and polycyclic aromatic hydrocarbons (PAHs) became an indispensable requirement of the current era. Although the CEC are useful for wide-spectrum purposes, they can also result in undesirable effects on human health and other animals....
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DNA methylation in cancer development, diagnosis and therapy-multiple opportunities for genotoxic agents to act as methylome disruptors or remediators
PublicationThe role of DNA methylation and recently discovered hydroxymethylation in the function of the human epigenome is currently one of the hottest topics in the life sciences. Progress in this field of research has been further accelerated by the discovery that alterations in the methylome are not only associated with key functions of cells and organisms, such as development, differentiation and gene expression, but may underlie a number...
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Regenerative Drug Discovery Using Ear Pinna Punch Wound Model in Mice
PublicationThe ear pinna is a complex tissue consisting of the dermis, cartilage, muscles, vessels, and nerves. Ear pinna healing is a model of regeneration in mammals. In some mammals, including rabbits, punch wounds in the ear pinna close spontaneously; in common-use laboratory mice, they remain for life. Agents inducing ear pinna healing are potential regenerative drugs. We tested the effects of selected bioactive agents on 2 mm ear pinna...
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Effect of synthesis method parameters on properties and photoelectrocatalytic activity under solar irradiation of TiO2 nanotubes decorated with CdS quantum dots
PublicationThe growing research interest on photoelectrocatalysis has encouraged the search for new materials with high activity and the development of methods for their synthesis. The successive ionic layer adsorption and reaction (SILAR) method is an effective way to synthesize materials with photoelectrocatalytic (PEC) properties that are active under visible radiation. Therefore, studies on the impact of the parameters of the SILAR method...
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Palindromic carbazole derivatives: unveiling their antiproliferative effect via topoisomerase II catalytic inhibition and apoptosis induction
PublicationHuman DNA topoisomerases are essential for crucial cellular processes, including DNA replication, transcription, chromatin condensation, and maintenance of its structure. One of the significant strategies employed in cancer treatment involves the inhibition of a specific type of topoisomerase, known as topoisomerase II (Topo II). Carbazole derivatives, recognised for their varied biological activities, have recently become a significant...
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Mitigating metal-organic framework (MOF) toxicity for biomedical applications
PublicationMetal-organic frameworks (MOFs) are a novel class of crystalline porous materials, consisting of metal ions and organic linkers. These hybrid materials are highly porous and have a large specific surface area, making them of great interest for applications in gas separation, energy storage, biomedical imaging, and drug delivery. As MOFs are being explored for biomedical applications, it is essential to comprehensively assess their...
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Model tests of cast-in-place piles formed by using different types of auger
PublicationModel tests are still a popular research tool used to observe and determine the mechanisms of pile-soil interaction. Due to the significant scale effect, the results of model tests performed in the 1g system can only be analysed from the qualitative side. This article describes and presents the results of 1g pile model tests carried out for comparative purposes. There were tested the effectiveness and efficiency of various types...
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Edge-Computing based Secure E-learning Platforms
PublicationImplementation of Information and Communication Technologies (ICT) in E-Learning environments have brought up dramatic changes in the current educational sector. Distance learning, online learning, and networked learning are few examples that promote educational interaction between students, lecturers and learning communities. Although being an efficient form of real learning resource, online electronic resources are subject to...
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Consequences of New Approach of Chemical Stability Tests of Active Pharmaceutical Ingredients (APIs)
PublicationThere is a great need of broaden look on stability tests of active pharmaceuticalingredients (APIs) in comparison with current requirements contained in pharmacopeia.By usage of many modern analytical methods the conception of monitoring the changesof APIs during initial stage of their exposure to harmful factors has been developed. Newknowledge must be acquired in terms of identification of each degradation...
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Corporate social responsibility and forward default risk under firm and industry heterogeneity
PublicationObjective: This study aims to evaluate the impact of corporate social responsibility on forward default risk (FDR) under the setting of firm and industry heterogeneity. Research Design & Methods: This study evaluated the impact of corporate social responsibility (CSR) on FDR using the data of 497 companies from 2007-2021 in the S&P 500 index, taking into account firm and industry heterogeneity aspects. This study utilized instrumental...
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An insight into the mixed quantum mechanical-molecular dynamics simulation of a ZnII-Curcumin complex with a chosen DNA sequence that supports experimental DNA binding investigations
PublicationAn important aspect of research pertaining to Curcumin (HCur) is the need to arrest its degradation in aqueous solution and in biological milieu. This may be achieved through complex formation with metal ions. For this reason, a complex of HCur was prepared with ZnII, that is not likely to be active in redox pathways, minimizing further complications. The complex is monomeric, tetrahedral, with one HCur, an acetate and a molecule...
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Analysis of the causes and effects of cyclist-pedestrian accidents in biggest Polish cities
PublicationTraffic incidents between pedestrians and cyclists result in an incomparably smaller number of victims (injured and killed) than accidents between unprotected traffic participants and other vehicles. However, such incidents cannot be underestimated, as in most cases they take place on elements of infrastructure designed for pedestrians and cyclists, and thus negatively affect the sense of safety of users in places where they...
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Media architecture for post-modern society - new forms of participation
PublicationThe article shows the relationship between the characteristics of the post-modern society, and the development of media architecture with the function of interactivity. In this context, the duality of the features of post-modern society was emphasized: taking into account its location between creativity and consumerism, as well as on the border between the real and virtual word. The development of media architecture has been linked...
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Advances in analysis, quantification and modelling of N2O emission in SBRs under various DO set points
PublicationNitrous oxide (N2O), considered a major greenhouse gas (GHG) in wastewater treatment plants (WWTPs), is produced during both nitrification and denitrification processes; hence, it needs to be controlled by internal and external strategies. Various factors, such as DO, temperature, and pH, could be incorporated into the mitigation of emissions in WWTPs. In this research, potential operational strategies were investigated in order...
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Absorptive Desulfurization of Model Biogas Stream Using Choline Chloride-Based Deep Eutectic Solvents
PublicationThe paper presents a synthesis of deep eutectic solvents (DESs) based on choline chloride (ChCl) as hydrogen bond acceptor and phenol (Ph), glycol ethylene (EG), and levulinic acid (Lev) as hydrogen bond donors in 1:2 molar ratio. DESs were successfully used as absorption solvents for removal of dimethyl disulfide (DMDS) from model biogas steam. Several parameters affecting the absorption capacity and absorption rate have been...