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Search results for: ANTI-ANTI-ID
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Improved degradation of etodolac in the presence of core-shell ZnFe2O4/SiO2/TiO2 magnetic photocatalyst
PublicationIn the present study, susceptibility to photocatalytic degradation of etodolac, 1,8-diethyl-1,3,4,9 – tetrahydro pyran - [3,4-b] indole-1-acetic acid, which is a non-steroidal anti-inflammatory drug frequently detected in an aqueous environment, was for the first time investigated. The obtained p-type TiO2-based photocatalyst coupled with zinc ferrite nanoparticles in a core-shell structure improves the separation and recovery...
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Determination of bromhexine and its metabolites in equine serum samples by liquid chromatography – Tandem mass spectrometry: Applicability to the elimination study after single oral dose
PublicationBromhexine (BH), expectorant used in the treatment of respiratory disorders associated with viscid or excessive mucus, is not permitted for use in the competing horse by many authorities in horseracing and Olympic disciplines. Metabolic studies are of the great importance in anti-doping field because they allow for updating the selection of the most appropriate markers for prohibited substances, such as metabolites present at higher...
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Mechanical and Corrosion Properties of Laser Surface-Treated Ti13Nb13Zr Alloy with MWCNTs Coatings
Publication: Titanium and its alloys is the main group of materials used in prosthetics and implantology. Despite their popularity and many advantages associated with their biocompatibility, these materials have a few significant disadvantages. These include low biologic activity—which reduces the growth of fibrous tissue and allows loosening of the prosthesis—the possibility of metallosis and related inflammation or other allergic reactions,...
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Emerging anticancer activity of candidal glucoseamine-6-phosphate synthase inhibitors upon nanoparticle-mediated delivery
PublicationNumerous glutamine analogues have been reported as irreversible inhibitors of the glucosamine-6-phosphate (GlcN-6-P) synthase in pathogenic Candida albicans in the last 3.5 decades. Among the reported inhibitors, the most effective N3-(4-methoxyfumaroyl)-L-2,3- diaminopropanoic acid (FMDP) has been extensively studied in order to develop its more active analogues. Several peptide−FMDP conjugates were tested to deliver FMDP to its...
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Pharmaceuticals and other contaminants of emerging concern in Admiralty Bay as a result of untreated wastewater discharge: Status and possible environmental consequences
PublicationConsidering how the impact of human activity in Antarctica is growing, the aim of this study was to conduct the first assessment of pharmaceuticals and personal care products (PPCPs), other emerging contaminants (ECs), and antibiotic resistance genes present in the western shore of the Admiralty Bay region of King George Island. In total, more than 170 substances were evaluated to assess the potential environmental risks they pose...
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Pedestrian Safety at Midblock Crossings on Dual Carriageway Roads in Polish Cities
PublicationRoad crossings across two or more lanes in one direction are particularly dangerous due to limited sight distance and high vehicle speeds. To improve their safety, road authorities should provide safety treatments. These may include additional measures to reduce speed and narrow the road cross-section and the introduction of active pedestrian crossings. Equipped with flashing lights activated automatically when a pedestrian is...
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Molecular basis of lipopolysaccharide heterogeneity in Escherichia coli: envelope stress-responsive regulators control the incorporation of glycoforms with a third 3-deoxy-α-D-manno-oct-2-ulosonic acid and rhamnose.
PublicationMass spectrometric analyses of lipopolysaccharide (LPS) from isogenic Escherichia coli strains with nonpolar mutations in the waa locus or overexpression of their cognate genes revealed that waaZ and waaS are the structural genes required for the incorporation of the third 3-deoxy-α-D-manno-oct-2-ulosonic acid (Kdo) linked to Kdo disaccharide and rhamnose, respectively. The incorporation of rhamnose requires prior sequential incorporation...
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The impact of cooking method on the phenolic composition, total antioxidant activity and starch digestibility of rice (Oryza sativa L.)
PublicationThis study investigated changes in the phenolic composition, total antioxidant activity (TAA) and starch digestibility in white and brown rice due to three different cooking procedures, and subsequent reheating of cooked rice after storage. Among the analyzed samples, brown rice showed the highest TAA and phenolic content (622.5 mg kg-1 DW). All cooking methods resulted in significant decrease of phenolic content and TAA of rice...
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Spatial distribution of pharmaceuticals in conventional wastewater treatment plant with Sludge Treatment Reed Beds technology
PublicationPharmaceutical residues are an emerging environmental problem. It is strongly confirmed that pharmaceuticals are present in soils and environmental waters (surface, marine and even groundwater), and that wastewater treatment plant (WWTP) effluents are the main source of pharmaceuticals in the watershed. The aim of this studywas to recognize the spatial distribution and seasonal changes of selected pharmaceuticals in conventional WWTP...
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NUTRITIONAL AND PHARMACEUTICAL APPLICATIONS OF BIOACTIVE COMPOUNDS IN TROPICAL FRUITS
PublicationDuring the past two decades our international scientific group investigated in vitro the physicochemical and nutritional characteristics of some cultivars of durian at various stages of ripening, mangosteen and new cultivars of snake fruit in comparison with widely used avocado, kiwifruit and mango, and in vivo their influence on laboratory animals. The main objective of the present study was to screen and compare the properties...
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Voltammetric and biological studies of folate-targeted non-lamellar lipid mesophases
PublicationFolate-targeted lipid nanostructures are promising strategies for the development of biocompatible drug delivery systems. The objective of this study was to evaluate the efficacy of drug delivery to cancer cells by folate-targeted lipid mesophases, cubosomes (CUB) and hexosomes (HEX), loaded with doxorubicin (DOX). Three cancer-derived cell lines (KB, HeLa, T98G) exhibiting different expressional levels of folate receptor protein...
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Performance of electrochemical immunoassays for clinical diagnostics of SARS-CoV-2 based on selective nucleocapsid N protein detection: Boron-doped diamond, gold and glassy carbon evaluation
PublicationThe 21st century has already brought us a plethora of new threats related to viruses that emerge in humans after zoonotic transmission or drastically change their geographic distribution or prevalence. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was first spotted at the end of 2019 to rapidly spread in southwest Asia and later cause a global pandemic, which paralyzes the world since then. We have designed novel...
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Non-toxic fluorine-doped TiO2 nanocrystals from TiOF2 for facet-dependent naproxen degradation
PublicationIn the present study, the photocatalytic degradation of naproxen (NPX), which is a nonsteroidal anti-inflammatory drug (NSAID), frequently detected in drinking water, was investigated. The F-doped TiO2 with defined morphology was successfully obtained from TiOF2 and applied for photocatalytic degradation under UV-vis and visible light. All samples were characterised by X-ray diffraction, scanning electron microscopy, X-ray photoelectron...
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Electrocatalytic performance of oxygen-activated carbon fibre felt anodes mediating degradation mechanism of acetaminophen in aqueous environments
PublicationCarbon felts are flexible and scalable, have high specific areas, and are highly conductive materials that fit the requirements for both anodes and cathodes in advanced electrocatalytic processes. Advanced oxidative modi- fication processes (thermal, chemical, and plasma-chemical) were applied to carbon felt anodes to enhance their efficiency towards electro-oxidation. The modification of the porous anodes results in increased...
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Serodiagnosis of Toxoplasma gondii infection in farm animals (horses, swine, and sheep) by enzyme-linked immunosorbent assay using chimeric antigens
PublicationToxoplasma gondii infects all warm-blooded animals including humans, causing serious public health problems and great economic loss in the animal husbandry. Commonly used serological tests for diagnosis of toxoplasmosis involve preparation of whole Toxoplasma lysate antigen (TLA) from tachyzoites. The production of this antigen is associated with high costs and lengthy preparation and the possibility of staff infection. There are...
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Anticancer imidazoacridinone C-1311 inhibits hypoxia-inducible factor-1α (HIF-1α), vascular endothelial growth factor (VEGF) and angiogenesis
PublicationAntitumor imidazoacridinone C-1311 is a DNA-reactive topoisomerase II and FLT3 receptor tyrosine kinase inhibitor. Here, we demonstrate the mechanism of C-1311 inhibitory action on novel targets: hypoxia-inducible factor-1α (HIF-1α), vascular-endothelial growth factor (VEGF), and angiogenesis. In a cell-free system, C-1311 prevented HIF-1α binding to an oligonucleotide encompassing a canonical hypoxia-responsive element (HRE),...
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Deep learning techniques for biometric security: A systematic review of presentation attack detection systems
PublicationBiometric technology, including finger vein, fingerprint, iris, and face recognition, is widely used to enhance security in various devices. In the past decade, significant progress has been made in improving biometric sys- tems, thanks to advancements in deep convolutional neural networks (DCNN) and computer vision (CV), along with large-scale training datasets. However, these systems have become targets of various attacks, with...
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Experimental and Theoretical Insights into the Intermolecular Interactions in Saturated Systems of Dapsone in Conventional and Deep Eutectic Solvents
PublicationSolubility is not only a crucial physicochemical property for laboratory practice but also provides valuable insight into the mechanism of saturated system organization, as a measure of the interplay between various intermolecular interactions. The importance of these data cannot be overstated, particularly when dealing with active pharmaceutical ingredients (APIs), such as dapsone. It is a commonly used anti-inflammatory and...
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The usefulness of Toxoplasma gondii MIC1-MAG1-SAG1 chimeric antigen in the serodiagnosis of ovine toxoplasmosis
PublicationToxoplasmosis is a zoonotic disease caused by the protozoan Toxoplasma gondii, which infects humans and most warm-blooded animals throughout the world. Although human toxoplasmosis in healthy adults is usually asymptomatic, a serious disease can occur in the case of congenital infection and immunocompromised individuals. Among food animals, sheep, along with goats and pigs, possess the highest incidence of T. gondii cysts in meat,...
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The II phase metabolism of endogenous and exogenous compounds, including antitumor chemotherapeutics
PublicationThe II phase metabolism, it is a set of metabolism and excretion pathways of endogenous as well as exogenous compounds including xenobiotics. UDP-glucuronyltransferases (UGTs; EC 2.4.1.17) are the most crucial representatives of II phase enzymes, which are responsible for the transformation of bilirubine and bile acids, steroids and thyroid hormones and lipids. Exogenous compounds, including drugs, carcinogens, environmental pollutants...
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The Effect of Surface Modification of Ti13Zr13Nb Alloy on Adhesion of Antibiotic and Nanosilver-Loaded Bone Cement Coatings Dedicated for Application as Spacers
PublicationSpacers, in terms of instruments used in revision surgery for the local treatment of postoperative infection, are usually made of metal rod covered by antibiotic-loaded bone cement. One of the main limitations of this temporary implant is the debonding effect of metal–bone cement interface, leading to aseptic loosening. Material selection, as well as surface treatment, should be evaluated in order to minimize the risk of fraction...
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Analysis of the Possibility of Using New Types of Protective Coatings and Abrasion-Resistant Linings under the Operating Conditions of the Spiral Classifier at KGHM Polska Miedź S.A. Ore Concentration Plant
PublicationA study was carried out to select the appropriate coatings for corrosion protection of the spiral classifier working at KGHM Polska Miedź S.A. Ore Concentration Plant. The abrasion resistance of selected protective coatings and wear-resistant linings was investigated using a DT-523 rotary abrasion tester with Taber CS-10 rubber abrasive discs. The average weight loss of the coatings after a cycle of 2000 revolutions was determined....
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Triplet–Triplet Annihilation Upconverting Liposomes: Mechanistic Insights into the Role of Membranes in Two-Dimensional TTA-UC
PublicationTriplet−triplet annihilation upconversion (TTA-UC) implemented in nanoparticle assemblies is of emerging interest in biomedical applications, including in drug delivery and imaging. As it is a bimolecular process, ensuring sufficient mobility of the sensitizer and annihilator to facilitate effective collision in the nanoparticle is key. Liposomes can provide the benefits of two-dimensional confinement and condensed concentration...
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Comparison of antimicrobial activity of selected, commercially available wound dressing materials
PublicationOBJECTIVE: The aim of our study was to examine the antimicrobial potential of eight selected, commercially available wound dressings containing different antimicrobial agents: silver, chlorhexidine acetate, povidone-iodine, and manuka honey. METHOD: The materials were tested against four reference strains of bacteria: Staphylococcus aureus (PCM 2051), Staphylococcus epidermidis (PCM 2118), Pseudomonas aeruginosa (ATCC 27853),...
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A method for the production of D-tagatose using a recombinant Pichia pastoris strain secreting beta-D-galactosidase from Arthrobacter chlorophenolicus and a recombinant L-arabinose isomerase from Arthrobacter sp. 22c
PublicationD-Tagatose is a natural monosaccharide which can be used as a low-calorie sugar substitute in food, beverages and pharmaceutical products. It is also currently being tested as an anti-diabetic and obesity control drug. D-Tagatose is a rare sugar, but it can be manufactured by the chemical or enzymatic isomerization of D-galactose obtained by a beta-D-galactosidase-catalyzed hydrolysis of milk sugar lactose and the separation of...
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ID 382 – Electrophysiological evaluation of emotional expressions in the facial transplantation patients
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Molecularly targeted nanoparticles: an emerging tool for evaluation of expression of the receptor for advanced glycation end products in a murine model of peripheral artery disease
PublicationAbstract Background: Molecular imaging with molecularly targeted probes is a powerful tool for studying the spatio-temporal interactions between complex biological processes. The pivotal role of the receptor for advanced glycation end products (RAGE) in numerous pathological processes, aroused the demand for RAGE targeted imaging in various diseases. In the study, we evaluated the use of a diagnostic imaging agent for RAGE quantification...
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The Chitosan-Based System with Scutellariae baicalensis radix Extract for the Local Treatment of Vaginal Infections
PublicationScutellarie baicalensis radix, as a flavone-rich source, exhibits antibacterial, antifungal, an-tioxidant, and anti-inflammatory activity. It may be used as a therapeutic agent to treat various
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Solubility of dapsone in deep eutectic solvents: Experimental analysis, molecular insights and machine learning predictions
PublicationBackground. Dapsone (DAP) is an anti-inflammatory and antimicrobial active pharmaceutical ingredient used to treat, e.g., AIDS-related diseases. However, low solubility is a feature hampering its efficient use. Objectives. First, deep eutectic solvents...
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Electronic Voting: 8th International Joint Conference, E-Vote-ID 2023, Luxembourg City, Luxembourg, October 3–6, 2023, Proceedings
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Electronic Voting: 8th International Joint Conference, E-Vote-ID 2023, Luxembourg City, Luxembourg, October 3–6, 2023, Proceedings
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ID and 2D Electron Spin Resonance Imaging (ESRI) of Nitroxide Radicals in Stabilized Poly(acrylonitrile−butadiene−styrene) (ABS): UV vs Thermal Degradation
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The sanitary quality of water and sandy sediments of selected streams and the coastal area of Gdańsk Bay
PublicationPraca prezentuje wyniki badań bakteriologicznych przybrzeżnych wód morskich i plażowych osadów piaszczystych prowadzonych w rejonie ujścia do Zatoki Gdańskiej rzeki Kaczej i Sweliny oraz Potoków Grodowego i Kamiennego. W badaniach określano liczbę bakterii względnie psychrofilnych, mezofilnych oraz bakterii wskaźnikowych (bakterii z grupy coli, coli typu kałowego oraz paciorkowców kałowych). Stwierdzono, iż potoki wnoszą znaczny...
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New products of reaction of Lawesson's reagent with diols.
PublicationW artykule przedstawiono syntezę i szczegółową charakterystykę strukturalną i konformacyjną 8-, 9- i 10-członowych pierścieniowych związków heterocyklicznych o unikatowym układzie atomów O-P-S-S. W wyniku reakcji a,w-dioli z odczynnikiem Lawessona wobec zasad powstają odpowiednie sole kwasów bisditiofosfonowych, które po utlenieniu dają w/w pierścieniowe disulfidy. Kwasy bisditiofosfonowe przekształcono także w trwałe diestry S-metylowe,...
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Single chamber electrolyte supported SOFC module.
PublicationZaproponowano konstrukcję modułu składającego się z dwóch jednokomorowych ogniw paliwowych SOFC na nośnym elektrolicie. Moduł zbudowany jest z jednego substratu z tlenku ceru i domieszkowanym samarem oraz dwóch anod z cermetu na bazie tlenku niklu i dwóch katod z perovskitu LSCF. Przygotowano i zbadano moduły z różną powierzchnią elektrod, które były testowane w mieszaninach powietrza i propanu. Wielkość elektrod miała silny wpływ...
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Anode supported single chamber solid oxide fuel cell in CH4-Air Mixture.
PublicationW tej pracy przedstawiono wyniki prac ogniw paliwowych na bazie elektrolitu z tlenku cyrkonu stabilizowanego itrem o grubości 1-2um wytworzonego na podłożu cermetu z tlenku niklu i tlenku cyrkonu stabilizowanego itrem. LSCF był wykorzystany jako katoda. Ogniwo paliwowe było testowane w konfiguracji jednokomorowej w mieszaninie powietrza i metanu. Uzyskano napięcie o wartości 0.8V, zaś moc wynosiła 0.12W/cm2. Zbdadano wpływ przepływu...
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Role of composite cathodes in single chamber SOFC.
PublicationZbadano wpływ składu katody na napięcie oraz wydajność ogniw paliwowych pracujących w konfiguracji jednokomorowej. W związku z tym, że takie ogniwo pracuje w mieszanienie powietrza i paliwa, napięcie jest określone przez różnice aktywności katalitycznej anody i katody. Typowy cermet na bazie niklu oraz związki perovskitów pracują dobrze odpowiednio jako anoda i katoda. Jednakże perowskity mają również właściwości katalityczne,...
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Low-temperature processing of thin-film electrolyte for electrochemical devices.
PublicationPrzygowanie filmów elektrolitu jest jednym z najbardziej istotnych procesów technologicznych wytworzenia urządzeń elektrochemicznych takich jak ogniwa paliwowe. Zmniejszenie grubości filmu jest powiązane ze zmniejszeniem rezystancji elektrolitu, co bardzo korzystnie wpływa na wydajność ogniw paliwowych. W pracy tej przedstawiono niskotemperaturową (<1000C) metodę wytwarzenia filmów elektrolitu z tlenku cyrkonu stabilizowanego itrem...
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Projektowanie zbiornika na nieczystości ciekłe
PublicationW artykule przedstawiono proces projektowania zbiornika podziemnego na nieczystości ciekłe o pojemności ok. 10 m3 posadowionego na gruntach niespoistych (sypkich). Porównano wartości sił wewnętrznych w przypadku skrajnie różnych warunków gruntowych: piasku drobnego o ID = 0,2 oraz żwiru o I D = 0,7. Dodatkowo przeanalizowano wpływ modelu obliczeniowego podłoża na wyniki sił wewnętrznych. Opisano procedurę normową pozwalającą na...
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Projektowanie poszerzeń międzytorzy w aspekcie zmian dopuszczalnych wartości parametrów geometrycznych i kinematycznych
PublicationW latach 2014–2015 w Polsce wprowadzono długo oczekiwane nowelizacje warunków technicznych, jakim powinny odpowiadać budowle kolejowe i ich usytuowanie (zawartych w Dzienniku Ustaw nr 151 poz. 987 z 1998 r.) oraz Warunków technicznych Id-1. Wprowadziły one istotne zmiany w dopuszczalnych wartościach parametrów geometrycznych i kinematycznych, mających bezpośredni wpływ na projektowanie geometrii toru kolejowego. Z uwagi na duże...
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Wpływ zmian dopuszczalnych wartości parametrów geometrycznych i kinematycznych na podatność modernizacyjną układów torowych
PublicationPodatnością modernizacyjną nazywamy stopień przystosowania analizowanego odcinka linii kolejowej do zmiany prędkości eksploatacyjnej. Skala możliwych zmian prędkości (w sensie jej zwiększenia) jest wypadkową istniejącego układu geometrycznego linii w planie, ograniczeń lokalizacyjnych oraz dopuszczalnych wartości parametrów geometrycznych i kinematycznych. Jakiekolwiek zmiany tych ostatnich wpływają bezpośrednio na obliczenie elementarnych...
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Application of adjusted subpixel method (ASM) in HRCT measurements of the bronchi in bronchial asthma patients and healthy individuals
PublicationBackground: Recently, we described a model system which included corrections of high-resolution computedtomography (HRCT) bronchial measurements based on the adjusted subpixel method (ASM).Objective: To verify the clinical application of ASM by comparing bronchial measurements obtained bymeans of the traditional eye-driven method, subpixel method alone and ASM in a group comprised ofbronchial asthma patients and healthy individuals.Methods:...
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Porównanie parametrów stanu nasypu kontrolowanego na podstawie badań płytą dynamiczną i sondą dynamiczną
PublicationOmówiono polowe badania porównawcze lekką płytą dynamiczną (LWD) oraz sondą dynamiczną lekką (DPL). Określono zależności korelacyjne między dynamicznym modułem odkształcenia EVd i stopniem zagęszczenia ID.
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Wpływ zmian dopuszczalnych wartości parametrów geometrycznych i kinematycznych na podatność modernizacyjną układów torowych
PublicationPodatnością modernizacyjną nazywamy stopień przystosowania analizowanego odcinka linii kolejowej do zmiany prędkości eksploatacyjnej. Skala możliwych zmian prędkości (w sensie jej zwiększenia) jest wypadkową istniejącego układu geometrycznego linii w planie, ograniczeń lokalizacyjnych oraz dopuszczalnych wartości parametrów geometrycznych i inematycznych. Jakiekolwiek zmiany tych ostatnich wpływają bezpośrednio na obliczenie elementarnych...
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Seismic response and performance prediction of steel buckling-restrained braced frames using machine-learning methods
PublicationNowadays, Buckling-Restrained Brace Frames (BRBFs) have been used as lateral force-resisting systems for low-, to mid-rise buildings. Residual Interstory Drift (RID) of BRBFs plays a key role in deciding to retrofit buildings after seismic excitation; however, existing formulas have limitations and cannot effectively help civil engineers, e.g., FEMA P-58, which is a conservative estimation method. Therefore, there is a need to...
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Data on LEGO sets release dates and worldwide retail prices combined with aftermarket transaction prices in Poland between June 2018 and June 2023
PublicationThe dataset contains LEGO bricks sets item count and pricing history for AI-based set pricing prediction. The data spans the timeframe from June 2018 to June 2023. The data was obtained from three sources: Brickset.com (LEGO sets retail prices, release dates, and IDs), Lego.com official web page (ID number of each set that was released by Lego, its retail prices, the current status of the set) and promoklocki.pl web page (the retail...
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System do pomiaru szumów elementów optoelektronicznych w szerokim zakresie prądów
PublicationW artykule zostanie zaprezentowany opis systemu pomiarowego zawierającego zaprojektowaną głowicę pomiarową do pomiarów szumów generowanych przez elementy optoelektroniczne. Przedstawione zostaną wyniki testów funkcjonowania systemu pomiarowego dla diod LED dla prądu wynoszącego ID = 2 mA. Pomiar odbywał się w zakresie małych częstotliwości czyli do 1 kHz. Głowica pomiarowa została zbudowana w sposób minimalizujący wpływ zakłóceń zewnętrznych...
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Application of smart glasses for fast and automatic color correction in health care
PublicationIn recent years different applications of smart glasses in health care have been proposed. In this paper we present the experiments related to automatic color correction using smart glasses platform developed within the eGlasses project. The color pattern is proposed and tested enabling the automatic detection of the pattern and automatic correction of colors. Additionally, the method for encoding and decoding of patient ID in...
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In Situ Random Microseeding and Streak Seeding Used for Growth of Crystals of Cold-Adapted beta-D-Galactosidases: Crystal Structure of betaDG from Arthrobacter sp. 32cB
PublicationThere is an increasing demand for cold-adapted enzymes in a wide range of industrial branches. Nevertheless, structural information about them is still scarce. The knowledge of crystal structures is important to understand their mode of action and to design genetically engineered enzymes with enhanced activity. The most difficult task and the limiting step in structural studies of cold-adapted enzymes is their crystallization,...
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Kryteria kontroli jakości zagęszczania wgłębnego gruntów niespoistych
PublicationEtapy kontroli jakości procesu zagęszczania wgłębnego gruntów niespoistych. Ocena przydatności danego gruntu do zagęszczania, wstępny dobór parametrów zagęszczania oraz ich weryfikacja na poletkach doświadczalnych, obserwacja osiadań i badania sprawdzające w postaci sondowań statycznych metodą CPTU, badań dylatometrycznych DMT, badań presjometrycznych PMT oraz sondowań dynamicznych DPT. Dyskusja kryteriów kontroli jakości zagęszczania...