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Search results for: EFFECTIVE WIDTH OF FLANGE
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Prime-Boost Vaccination with Toxoplasma Lysate Antigen, but Not with a Mixture of Recombinant Protein Antigens, Leads to Reduction of Brain Cyst Formation in BALB/c Mice
PublicationIntroduction Infection with the ubiquitous parasite Toxoplasma gondii is a threat for immunocompro- mised patients and pregnant women and effective immune-prophylaxis is still lacking. Methods Here we tested a mixture of recombinant T . gondii antigens expressed in different develop- mental stages, i.e., SAG1, MAG1 and GRA7 (SMG), and a lysate derived from T . gondii tachyzoites (TLA) for prophylactic vaccination against cyst formation....
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Anticancer imidazoacridinone C-1311 inhibits hypoxia-inducible factor-1α (HIF-1α), vascular endothelial growth factor (VEGF) and angiogenesis
PublicationAntitumor imidazoacridinone C-1311 is a DNA-reactive topoisomerase II and FLT3 receptor tyrosine kinase inhibitor. Here, we demonstrate the mechanism of C-1311 inhibitory action on novel targets: hypoxia-inducible factor-1α (HIF-1α), vascular-endothelial growth factor (VEGF), and angiogenesis. In a cell-free system, C-1311 prevented HIF-1α binding to an oligonucleotide encompassing a canonical hypoxia-responsive element (HRE),...
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Implementing artificial intelligence in forecasting the risk of personal bankruptcies in Poland and Taiwan
PublicationResearch background: The global financial crisis from 2007 to 2012, the COVID-19 pandemic, and the current war in Ukraine have dramatically increased the risk of consumer bankruptcies worldwide. All three crises negatively impact the financial situation of households due to increased interest rates, inflation rates, volatile exchange rates, and other significant macroeconomic factors. Financial difficulties may arise when the...
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Comparing Apples and Oranges: A Mobile User Experience Study of iOS and Android Consumer Devices
PublicationWith the rapid development of wireless networks and the spread of broadband access around the world, the number of active mobile user devices continues to grow. Each year more and more terminals are released on the market, with the smartphone being the most popular among them. They include low-end, mid-range, and of course high-end devices, with top hardware specifications. They do vary in build quality, utilized type of material,...
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Physics-Based Coarse-Grained Modeling in Bio- and Nanochemistry
PublicationCoarse-grained approaches, in which groups of atoms are represented by single interaction sites, are very important in biological and materials sciences because they enable us to cover the size- and time-scales by several orders of magnitude larger than those available all-atom simulations, while largely keeping the details of the systems studied. The coarse-grained approaches differ by the scheme of reduction and by the origin...
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Implementation of Business Intelligence in an IT organization - the concept of an evaluation model
PublicationThis paper presents the issue of assessing the validity and effectiveness of implementing a Business Intelligence system in an IT Support Organization. This entity provides IT services to external clients involving, in particular, the storage and processing of large amounts of data. The vast amount of realized projects and also incidents reported in connection with those projects prevented effective decisions from being made without...
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Environmentally Oriented Models and Methods for the Evaluation of Drug x Drug Interaction Effects
PublicationThis detailed review compares known and widely used methods for drug interaction estimation, some of which now have historical significance. Pharmaceutical application has been noted as far back as several thousand years ago. Relatively late in the 20th century, however, researchers became aware that their fate and metabolism, which still remain a great challenge for environmental analysts and risk assessors. For the patient’s...
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Problems in designing and operating the functional safety solutions of higher integriity levels
PublicationThe aim of this article is to identify and discuss some problems that have been encountered in designing and operating the functional safety solutions of higher safety integrity levels (SIL 3 and SIL 4) in the light of analyses outlined in a new version of the international standard IEC 61508:2010. Examples of such solutions are the electric / electronic / programmable electronic systems (E/E/PESs) and the safety instrumented systems...
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Determination of Chemical Oxygen Demand (COD) at Boron-doped Diamond (BDD) Sensor by Means of Amperometric Technique
PublicationA boron-doped diamond (BDD) sensor was proposed for effective detection of chemical oxygen demand (COD) by means of amperometric technique. Thin boron doped diamond active sensor layer was deposited on Si wafer and glassy carbon substrate by Microwave Plasma Enhanced Chemical Vapor Deposition (MW PE CVD). The structure of BDD was confirmed by Raman spectra analysis. Broad Raman bands centered at 482 cm-1 and 1219 cm-1 are typical...
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Effect of Compounding Conditions on Static and Dynamic Mechanical Properties of High Density Polyethylene/Ground Tire Rubber Blends
PublicationSearching for new and cost-effective methods of waste rubber recycling is a subject of research in many scientific centers in the world. In this paper there are presented results of the research of the extrusion process of cheap and environmentally friendly thermoplastic compositions containing 50 % wt. of masses of ground tire rubber (GTR). The aim of this study was to determine the relationship between the mixing conditions and...
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Application of magnetic nanoparticles for magnetic solid-phase extraction in preparing biological, environmental and food samples
PublicationThe need to obtain meaningful results as the basis for determining the content of trace amounts of analytes has become the driving force behind the development of modern analytical techniques, including sample-preparation techniques, such as solid-phase extraction (SPE). Recently, great interest was aroused in the use of magnetic nanoparticles (MNPs) in SPE. These materials exhibit high selectivity, and, in small amounts, can provide...
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Determination of chemical oxygen demand (cod) at boron-doped diamond (bdd) sensor by means of amperometric technique
PublicationA boron-doped diamond (BDD) sensor was proposed for effective detection of chemical oxygen demand (COD) by means of amperometric technique. Thin boron doped diamond active sensor layer was deposited on Si wafer and glassy carbon substrate by Microwave Plasma Enhanced Chemical Vapor Deposition (MW PE CVD). The structure of BDD was confirmed by Raman spectra analysis. Broad Raman bands centered at 482 cm-1 and 1219 cm-1 are typical...
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A Perspective on Fast-SPICE Simulation Technology
PublicationThis chapter presents an introduction to the area of accelerated transistor-level (‘fast-SPICE’) simulation for automated verification and characterization of integrated circuits (ICs) from technologist’s perspective. It starts with outlining goals, expectations and typical usage models for fast-SPICE simulators, stressing how they differ from regular SPICE tools. It continues with presenting and classifying core technologies typically...
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Generic emergence of classical features in quantum Darwinism
PublicationQuantum Darwinism posits that only specific information about a quantum system that is redundantly proliferated to many parts of its environment becomes accessible and objective, leading to the emergence of classical reality. However, it is not clear under what conditions this mechanism holds true. Here we prove that the emergence of classical features along the lines of quantum Darwinism is a general feature of any quantum dynamics:...
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Dynamic soil improvement by hybrid technologies
PublicationHybrid method of subsoil improvement for road embankment foundation is described. This method is composed of two wellknown methods: dynamic replacement (DR) and microblasting (DDC) one (Deep Dynamic Compaction). The method was used for both the strengthening of the fully saturated organic subsoil as well as for acceleration of the consolidation of the organic layers. The practice ensures the expected results. A proper example on...
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Partial characterization of three Korean white lotus cultivars
PublicationThe nutritional and bioactive values of Korean white lotus cultivars (Muan, Chungyang, and Garam)extracted with methanol, water, and acetone solvents were evaluated by the contents of their bioactive compounds and antioxidant activity determined by ABTS, CUPRAC, FRAP, DPPH, and β-carotene-linoleic acid assays. HPLC, fluorometry, and FTIR spectroscopy were employed for evaluation of polyphenols and fatty acids. All lotus cultivar...
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Influence of a lipid bilayer on the conformational behavior of amphotericin B derivatives - A molecular dynamics study.
PublicationAmphotericin B (AmB) is an effective but very toxic antifungal antibiotic. In our laboratory a series of AmB derivatives of improved selectivity of action was synthesized and tested. To understand molecular basis of this improvement, comparative conformational studies of amphotericin B and its two more selectivederivatives were carried out in an aqueous solution and in a lipid membrane. These molecular simulation studies revealed...
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Extending GQM by argument structures
PublicationEffective metrics definition methods are of particular importance, as measurement mechanisms are indispensable in virtually any engineering discipline. The paper describes how the well known Goal-Question-Metric (GQM) method of systematic metrics derivation from measurement goals can be extended by applying argument structures. The proposed approach is called Goal-Argument-Metric (GAM). We briefly introduce general ideas of GQM...
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Towards systemic functional safety and security management in hazardous plants
PublicationThe aim of this article is to identify and discuss some issues related to functional safety and security management in hazardous industrial plants. The safety functions are to be realised using the electric / electronic / programmable electronic systems (E/E/PESs) or the safety instrumented systems (SISs) that are designed and operated respectively according to IEC 61508 and IEC 61511 requirements in life cycle. Although the role...
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Positron scattering on molecular hydrogen: Analysis of experimental and theoretical uncertainties
PublicationExperiments performed in recent years on positron scattering from molecular hydrogen indicated a rise of the total cross section in the limit of zero energy, but essentially disagree on the amplitude of this rise. Mitroy and collaborators [J.-Y. Zhang et al., Phys. Rev. Lett. 103, 223202 (2009)] predicted a scattering length somewhat different from values deduced experimentally. Using a Markov chain Monte Carlo modified effective...
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Optimization of Graphene Oxide Synthesis and Its Reduction
PublicationIn this article, we present the review of the chemical methods of synthesis of graphene oxide and its reduction in order to obtain the so-called reduced graphene oxide (rGO) whose properties are similar to those of pure graphene. We also present our experiments and the results in this field and the comparison of the efficiency of different methods of synthesis as well as the reduction of graphene oxide. To characterize the obtained...
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Beta-galactosidase activity of Meiothermus ruber cells
PublicationFreeze-dried cells of Meiothermus ruber catalyses cleavage of o-nitrophenyl-b-D-galactopiranoside (oNPb-gal) and conversion of lactose into glucose and galactose. The permeabilization with 2%toluene,20%ethanol and 20%acetone increased enzymatic activity from 74.87 U/g of lyophilized cells up to 129.44,114.38 and 90.19 U/g,respectively. Ethanol was an effective permeabilizing agent and its efficiency was dependent on the concentration,...
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Extending GQM by Argument Structures
PublicationEffective methods for metrics definition are of particular importance, as measurement mechanisms are indispensable in virtually any engineering discipline. The paper describes how the well known Goal-Question-Metric (GQM) method of systematic metrics derivation from measurement goals can be extended by applying argument structures. The proposed approach is called Goal-Argument-Metric (GAM). The general ideas of GQM and GAM are...
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Gender, equality, science and information systems
PublicationIn the entire Europe more women than men graduate from tertiary education institutes1. However, they are underrepresented in scientific and engineering disciplines. Women researchers still constitute a minority in the Government and Higher Education Sectors that both are related to power. A number of industry reports highlight a low number of women in IT occupations2. The EU Member States have, on political levels, committed themselves...
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Solution of the dike-break problem using finite volume method and splitting technique
PublicationIn the paper the finite volume method (FVM) is presented for the solution of two-dimensional shallow water equations. These equations are frequently used to simulate the dam-break and dike-break induced flows. The applied numerical algorithm of FVM is based on the wave-propagation algorithm which ensures a stable solution and simultaneously minimizes the numerical errors. The dimensional decomposition according to the coordinate...
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The use of bioassays in the analysis of environmental samples
PublicationToxicological tests are increasingly used as effective tool to complement the information obtained during the environmental monitoring. Moreover bioassays provide basic knowledge about the health effects of exposure to harmful factors associated with the environment. Toxicity tests might be a source of information about the content of pollutants in the sample, and the possibility of their interactions. They can be considered as...
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Measurements of transmission properties of Acoustic Communication Channels
PublicationTough transmission properties of shallow water acoustic channels (SWAC) highly limit the use of underwater acoustic communication (UAC) systems. An adaptive matching of modulation and signaling schemes to instantaneous channel conditions is needed for reliabledata communications. This creates, however, unique challenges for designers when compared to radio transmission systems. When communication system elements are in move, the...
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New Analogues of Mycophenolic Acid
PublicationMycophenolic acid (MPA) possesses antibacterial, antifungal, antiviral, immunosuppressive and anticancer properties. It is a non-competitive and reversible inhibitor of dehydrogenase inosine-5'-monophosphate (IMPDH). This compound belongs to the immunosuppressive drugs used for the prevention of both acute and chronic transplant rejection. Until now, two derivatives of MPA have been used clinically: mycophenolate mofetil (MMF,...
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Detection of apple in orange juice using ultra-fast gas chromatography
PublicationThe determination of authenticity is an increasingly important issue for food quality and safety. The use of an electronic nose based on ultra-fast gas chromatography technique ensures rapid analysis of the volatile compounds from food products. Due to the fact that this technique enables chemical profiling of agricultural products, it can be an effective tool for authentication when combined with chemometrics. In this article...
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Analysis of the Capability of Deep Learning Algorithms for EEG-based Brain-Computer Interface Implementation
PublicationMachine learning models have received significant attention for their exceptional performance in classifying electroencephalography (EEG) data. They have proven to be highly effective in extracting intricate patterns and features from the raw signal data, thereby contributing to their success in EEG classification tasks. In this study, we explore the possibilities of utilizing contemporary machine learning algorithms in decoding...
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Towards more inclusive qualitative research: the practice of interviewing neurominorities
PublicationManagement scholars increasingly focus their efforts on the development of neurodivergent human capital and the promotion of inclusive employment and decent work. However, it may be argued that existing research still suffers from the lack of a comprehensive appreciation of what neurominorities may find difficult in the research process or how they interpret what the researchers are doing. In the light of only fragmented advice...
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Trustworthy Applications of ML Algorithms in Medicine - Discussion and Preliminary Results for a Problem of Small Vessels Disease Diagnosis.
PublicationML algorithms are very effective tools for medical data analyzing, especially at image recognition. Although they cannot be considered as a stand-alone diagnostic tool, because it is a black-box, it can certainly be a medical support that minimize negative effect of human-factors. In high-risk domains, not only the correct diagnosis is important, but also the reasoning behind it. Therefore, it is important to focus on trustworthiness...
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Hydrogen Production Mechanism in Low-Temperature Methanol Decomposition Catalyzed by Ni3Sn4 Intermetallic Compound: A Combined Operando and Density Functional Theory Investigation
PublicationHydrogen production from methanol decomposition to syngas (H2 + CO) is a promising alternative route for clean energy transition. One major challenge is related to the quest for stable, cost-effective, and selective catalysts operating below 400 °C. We illustrate an investigation of the surface reactivity of a Ni3Sn4 catalyst working at 250 °C, by combining density functional theory, operando X-ray absorption spectroscopy, and high-resolution...
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Assessment of wastewater quality indicators for wastewater treatment influent using an advanced logistic regression model
PublicationInfluent quality indicators play a significant role in wastewater treatment plant performance due to their correlation with reactor operations and effluent quality. However, selecting a specific/best parameter indicator for predicting influent wastewater quality is one of the challenges in wastewa- ter treatment. This study, therefore, focused on determining suitable variables as influent quality indicators. For this purpose, a...
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Identification of residual force in static load tests on instrumented screw displacement piles
PublicationOccurrence of the so-called residual force of an unknown value significantly disturbs interpretation of static load tests performed on piles equipped with additional measuring instruments. Screw displacement piles are the piling technology in which the residual force phenomenon is very common. Its formation mechanism is closely related to the installation method of this type of piles, which initiates generation of negative pile...
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Concept of Multifactor Method and Non-Functional Requirements Solution to Increase Resilience through Functional Safety with Cybersecurity Analysis
PublicationIn the process of designing safety systems, an integrated approach in safety and cybersecurity analysis is necessary. The paper describes a new technique of increasing resilience through integrated analysis of functional safety and cybersecurity. It is a modeling methodology based on the combination of the multifactor method utilizing modified risk graphs, used previously for Safety Integrity Level (SIL) assessment, and the Non-Functional...
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iPP/HDPE blends compatibilized by a polyester: An unconventional concept to valuable products
PublicationPolyolefins are the most widely used plastics accounting for a large fraction of the polymer waste stream. Although reusing polyolefins seems to be a logical choice, their recycling level remains disappointingly low. This is mainly due to the lack of large-scale availability of efficient and inexpensive compatibilizers for mixed polyolefin waste, typically consisting of high-density polyethylene (HDPE) and isotactic polypropylene...
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The Application of Fluidic Sealing in Shrouded Gas Turbine Blades
PublicationThis paper presents a study conducted on a new gas turbine designed to limit leakage in the labyrinth seal. The slots in the fin are used to generate a bypass flow, which obstructs the flow in the gap above the fin. The method was tested numerically and experimentally beforehand using a simplified model without rotation or blade passages. In this paper, the validation of the method using a model of a turbine stage is shown. Reynolds-averaged...
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A simple and efficient hybrid discretization approach to alleviate membrane locking in isogeometric thin shells
PublicationThis work presents a new hybrid discretization approach to alleviate membrane locking in isogeometric finite element formulations for Kirchhoff–Love shells. The approach is simple, and requires no additional dofs and no static condensation. It does not increase the bandwidth of the tangent matrix and is effective for both linear and nonlinear problems. It combines isogeometric surface discretizations with classical Lagrange-based...
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Supporting study tours in the teaching of architectural heritage
PublicationStudy tours are a highly effective way to acquire knowledge. They improve students’ understanding of issues that otherwise may seem partly abstract to them. Presented in this article is the unique way in Poland in which support is given to the teaching of architectural heritage. It has been carried out continuously for almost 50 years in the Faculty of Architecture at Gdańsk University of Technology (FA-UT), Gdańsk, Poland, in...
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Photogrammetry image-based approach for imperfect structure modelling and FE analysis
PublicationThis study aims to model and analyse imperfect tructures using real measurements, employing photogrammetry technique commonly used in the geodesy. The study highlights the capability of the photogrammetry in aiding the structural analysis of imperfect engineering objects. Firstly, the photogrammetry measurements of a stiffened plate are carried out using a specially designed for the purpose experimental stand. Then, the plate surface...
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On thermal stability of piezo-flexomagnetic microbeams considering different temperature distributions
PublicationBy relying on the Euler–Bernoulli beam model and energy variational formula, we indicate critical temperature causes in the buckling of piezo-flexomagnetic microscale beams. The corresponding size-dependent approach is underlying as a second strain gradient theory. Small deformations of elastic solids are assessed, and the mathematical discussion is linear. Regardless of the pyromagnetic effects, the thermal loading of the thermal...
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Safety Integrity Verification Issues of the Control Systems for Industrial Process Plants
PublicationThe aim of this article is to identify and discuss some issues that can be encountered in designing the industrial automation and control systems (IACS) for implementing safety functions. In a functional safety standard IEC 61511 for the process industry such systems are named the basic process control systems (BPCS) and the safety instrumented systems (SIS). In a generic functional safety standard IEC 61508 they are depicted as...
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The Optimum Dataset method – examples of the application
PublicationData reduction is a procedure to decrease the dataset in order to make their analysis more effective and easier. Reduction of the dataset is an issue that requires proper planning, so after reduction it meets all the user’s expectations. Evidently, it is better if the result is an optimal solution in terms of adopted criteria. Within reduction methods, which provide the optimal solution there is the Optimum Dataset method (OptD)...
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Thermal degradation assessment of canola and olive oil using ultra-fast gas chromatography coupled with chemometrics
PublicationOil blending is often used to enhance the properties of vegetable oils. The admixture of a more thermally stable oil makes the resulting blend more suitable for use in frying. A new method of quality assessment of vegetable oils used in frying is presented in this paper. In this method, ultra-fast gas chromatography coupled with flame ionization detector and chemometrics is employed. Principal component analysis was used for data...
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APPLICABILITY OF INLET AIR FOGGING TO MARINE GAS TURBINE
PublicationThe dependency of marine gas turbine on the ambient temperature leads to a decrease of the gas turbine power output in arid areas. Very often gas turbine power output demand is high and the power margins originally designed into the driver , has been exhausted. In such circumstances the inlet air fogging is an effective compensation of gas turbine power. In this paper an analysis of inlet air fogging applicability to marine gas...
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INCREASING THE COUNTRY'S SECURITY AND PUBLIC TRANSPORT ACCESSIBILITY BY CREATING A NETWORK OF SMALL AIRPORTS
PublicationIt has been shown that by creating a network of small airports, it is possible to increase the communication accessibility of large population groups and the country's security, including safety at sea. The airports mentioned above may also be located on land considered to be weak from an engineering point of view. These include, for example, wetlands, swamps, flood embankments, poor coastal belt grounds, and reclaimed land. A...
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Computationally Effcient Solution of a 2D Diffusive Wave Equation Used for Flood Inundation Problems
PublicationThis paper presents a study dealing with increasing the computational efficiency in modeling floodplain inundation using a two-dimensional diffusive wave equation. To this end, the domain decomposition technique was used. The resulting one-dimensional diffusion equations were approximated in space with the modified finite element scheme, whereas time integration was carried out using the implicit two-level scheme. The proposed...
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Recent advances in aqueous virus removal technologies
PublicationThe COVID-19 outbreak has triggered a massive research, but still urgent detection and treatment of this virus seems a public concern. The spread of viruses in aqueous environments underlined efficient virus treatment processes as a hot challenge. This review critically and comprehensively enables identifying and classifying advanced biochemical, membrane-based and disinfection processes for effective treatment of virus-contaminated...
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Experiments and calibration of a bond-slip relation and efficiency factors for textile reinforcement in concrete
PublicationTextile reinforcement yarns consist of many filaments, which can slip relative each other. At modelling of the global structural behaviour, interfilament slip in the yarns, and slip between the yarns and the concrete can be considered by efficiency factors for the stiffness and strength of the yarns, and by applying a bond-slip relation between yarns and concrete. In this work, an effective and robust method for calibration of...