Search results for: SARS-COV-2 MAIN PROTEASE MPRO INHIBITION
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Analiza oddziaływań w kryształach związków zawierających w strukturze pierścień pirydynowy
PublicationMożliwość tworzenia się wiązań wodorowych jest kluczowym parametrem z punktu widzenia inżynierii kryształu, ponieważ wiązania wodorowe mają bezpośredni wpływ na strukturę oraz trwałość sieci krystalicznej. Głównym celem niniejszej rozprawy doktorskiej była analiza porównawcza wiązań wodorowych występujących w układach, zawierających w strukturze pierścień pirydynowy. Badane układy podzielono na: (1) układy ze związkami krzemosiarkowymi...
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ROSANNE Project: New Procedure for Noise Characterisation of Road Surfaces in Europe
PublicationROSANNE is a collaborative project in the 7th EU Framework Programme which aims at harmonising measurement methods for skid resistance, noise emission and rolling resistance of road pavements as a preparation for standardization. The project started in November 2013 and is developing and improving standards in the field of working group CEN/TC 227/WG 5. Regarding the influence of the pavement on the road traffic noise emission,...
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Feasibility of combined diesel engine - steam turbine in power station operating in the maritime
PublicationCompression-ignition engines used in ship technology as main propulsion engines are large units reaching even to 50-60 MW. Currently, the efficiency of such engines amounts to 45-50%. With such a large power unit, exhaust gases leaving the engine contain very large quantities of heat available for further treatment. Exhaust gases from the piston engine contain about 25% of the heat supplied to the engine in the fuel. Using the...
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Investigation and operation problems of metal tanks in Poland
PublicationThe paper consists of three parts concerned with steel cylindrical, vertical tank for liquid fuel. In the first part the present trends in tank design and building in Poland are described. The main are: · reduction of environment contamination danger caused by tank leakage and hydrocarbons evaporation, · increasing capacity of new tanks (100000 m3 and more) due to economic factor - reduction of steel amount per m3 of storage capacity....
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Metal dusting phenomena of 501 AISI furnace tubes in refinery fractional distillation unit
PublicationThe purpose of this investigation was to conduct the failure analysis of 501 AISI furnace tubes places before distillation column in fractional distillation unit. The investigated furnace tubes were planned to work for ten years however after just two years of exploitation <30% of the material left. The observed corrosion process had the intense and complex character. The well-adhered shiny black deposits and deep, round pits were...
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Study of the Layer-Type BST Thin Film with X-ray Diffraction and X-ray Photoelectron Spectroscopy
PublicationIn the present paper, results of X-ray photoelectron studies of electroceramic thin films of barium strontium titanate, Ba1xSrxTiO3 (BST), composition deposited on stainless-steel substrates are presented. The thin films were prepared by the sol-gel method. A spin-coating deposition of BST layers with different chemical compositions was utilized so the layer-type structure of (0-2) connectivity was formed. After the deposition,...
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B-GALACTOSIDASE ARTHROBACTER SP. 32cB - OBTAINING THE GENE SEQUENCE, CONSTRUCTION OF THE EXPRESSION SYSTEM, BIOSYNTHESIS AND BIOCHEMICAL CHARACTERIZATION OF THE ENZYME
PublicationINTRODUCTION: β-Galactosidase is an enzyme which catalyzes the hydrolysis of O glycosidic bond in β-galactosides. Another activity of β galactosidase is a transglycosylation activity. The main industrial use of this protein is the hydrolysis of lactose in milk in a cooling conditions. Synthesis of galactooligosaccharides, which are mostly used as a prebiotics added to some foods or available as dietary supplements, is only one...
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Cathodic activation of synthesized highly defective monoclinic hydroxyl‐functionalized ZrO2 nanoparticles for efficient electrochemical production of hydrogen in alkaline media
PublicationThe high electrochemical stability of Zirconia (ZrO2) at high potentials strongly suggested it as an alternative to carbon supports, which experience reduced efficiency due to some corrosion problems particularly during prolonged electrocatalysis activity. However, the use of ZrO2 was limited by its low electrical conductivity and surface area. In this work, we developed a methodology for synthesizing monoclinic ZrO2 NPs with increased...
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Caffeine Inhibits Differentiation Of Lung Cancer Stem Cells By Modulating Their Respiratory Metabolism
PublicationIt is ell established that many tumor types contain a fraction of cells, with stem cell-like properties, called cancer stem cells (CSCs), that are resistant to apoptosis induced by therapeutic agents. The presence of CSCs may explain why a standard anticancer treatment, that eliminates only differentiated cancer cells, does not lead to cancer cure.We previously showed the existence of caffeine-sensitive mechanism that controls...
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Activated sodium percarbonate-ozone (SPC/O3) hybrid hydrodynamic cavitation system for advanced oxidation processes (AOPs) of 1,4-dioxane in water
PublicationHydrodynamic cavitation (HC) was employed to activate sodium percarbonate (SPC) and ozone (O3) to degrade recalcitrant 1,4-dioxane. The degradation efficiency > 99 % with a rate constant of 4.04 × 10−2 min−1 was achieved in 120 min under the optimal conditions of cavitation number (Cv) 0.27, pH 5, molar ratio of oxidant to pollutant (rox) 8, ozone dose of 0.86 g h−1 under 25 ± 2 °C with initial concentration of 1,4-dioxane 100...
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Organic Rankine cycle as bottoming cycle to a combined Brayton and Clausius - Rankine cycle
PublicationA preliminary evaluation has been made of a possibility of bottoming of a conventional Brayton cycle cooperating with the CHP power plant with the organic Rankine cycle installation. Such solution contributes to the possibility of annual operation of that power plant, except of operation only in periods when there is a demand for the heat. Additional benefit would be the fact that an optimized backpressure steam cycle has the advantage...
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Effect of Base-Connection Strength and Ductility on the Seismic Performance of Steel Moment-Resisting Frames
PublicationColumn-base connections in steel moment-resisting frames (SMFs) in seismic regions are commonly designed to develop the capacity of adjoining column with an intent to develop a plastic hinge in the column member, rather than in the connection (i.e., a strong-base design). Recent research has shown base connections to possess high ductility, indicating that this practice may be not only expensive but also unnecessary. This suggests...
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Sea ice floe size and shape data from a very high resolution satellite image (Knox Coast, East Antarctica)
Open Research DataThis dataset contains floe size distribution data from a very high resolution (pixel size: 0.3 m) optical satellite image of sea ice, acquired on 16. Feb. 2019 off the Knox Coast (East Antarctica). The image shows relatively small ice floes produced by wave-induced breakup of landfast ice between the Mill Island and Bowman Island. The ice floes are...
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Ribosomal intergenic spacer analysis as a tool for monitoring methanogenic archaea changes in an anaerobic digester
PublicationThe applicability of a newly-designed PCR primer pair in examination of methanogenic Archaea in a digester treating plant biomass was evaluated by Ribosmal Intergenic Spacer Analysis (RISA). To find a suitable approach, three variants of RISA were tested: (1) standard, polyacrylamide gel-based, (2) automated, utilized capillary electrophoresis (GA-ARISA), and (3) automated microfluidics-based (MF-ARISA). All three techniques yielded...
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Speed dependency of temperature effects on road traffic noise
PublicationRecently, a new literature review on the influence of temperature on tire/road noise became available, based on a compilation of large amounts of data from empirical research. This review showed that the effect of temperature is roughly double of that previously assumed and taken account of in international standards. This makes temperature one of the main sources of error in measurement results. Furthermore, it suggested that...
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The best porous asphalt pavement in Sweden so far
PublicationIn 2010 a double-layer porous asphalt concrete (DPAC) pavement was constructed in various versions on the E4 motorway through the Swedish city Huskvarna. As a result of a court decision the Swedish Transport Administration had to reduce noise emission by applying a low noise road surface that would reduce A-weighted noise levels by 5 dB, as an average. Earlier experience in Sweden indicated that it was possible to obtain a high...
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A universal NDT method for examination of low energy impact damage in CFRP with the use of TLC film
PublicationThe article presents an attempt to use a sheet of laminated thermochromic liquid crystal film (TLC film) for non-destructive testing of the impact damage (energy values: 1J, 2J, 3J and 4J) in carbon fibre-reinforced polymer (CFRP). This is a new, alternative NDT approach based on the thermo-optical effect. The main advantages of this method are a) the low cost of TLC film, b) the low cost of recording devices due to the usage of...
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A Comparison of the Efficiency of Deammonification under Different Aeration Strategies in a Laboratory-Scale Sequencing Batch Reactor
PublicationAn important source of nitrogen load entering the biological part of wastewater treatment plants (WWPTs) is derived from the anaerobic sludge digestion processes. Sludge digestion liquors constitute only 1-2% of the inflow to the plant, but the load of nitrogen directed with them to the main stream may be as high as 10-20% of the total nitrogen load. Therefore, numerous studies have focused on treatment of sludge digestion liquors...
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Primary degradation of antidiabetic drugs
PublicationType 2 diabetes is a chronic disease affecting a large portion of the world population and is treated by orally administered drugs. Since these drugs are often taken in high doses and are excreted unchanged or partially metabolised many of them are nowadays detected in surface waters or wastewater treatment plants effluents. Unmetabolised antidiabetics or some of their transformation products retain their pharmacological activity,...
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In-tube extraction for the determination of the main volatile compounds in Physalis peruviana L
PublicationAn analytical procedure based on in-tube extraction followed by gas chromatography with mass spectrometry has been developed for the analysis of 24 main volatile components in cape gooseberry (Physalis peruviana L.) samples. According to their chemical structure, the compounds were organized into different groups: one hydrocarbon, one aldehyde, four alcohols, four esters, and 14 monoterpenes. By single-factor experiments, incubation...
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Real-time monitoring of the emission of volatile organic compounds from polylactide 3D printing filaments
PublicationEstablishing the emission profile of volatile organic compounds generated during fused deposition modeling 3D printing using polymer filaments is important in terms of both understanding the processes taking place during thermal degradation of thermoplastics, and assessing the user's exposure to potentially harmful volatiles. However, obtaining detailed, real-time qualitative and quantitative results poses a challenge. In this...
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Phenolic compounds from Nerium oleander leaves: microwave assisted extraction, characterization, antiproliferative and cytotoxic activities
PublicationA microwave-assisted extraction (MAE) method was used for the extraction of phenolic compounds from Nerium oleander leaves. The influence of variables such as ethanol concentration, microwave power, irradiation time and liquid/solid ratio on polyphenol extraction was modelled using a second-order regression equation based on response surface methodology (RSM). The optimal conditions for MAE were: extraction solvent 35% ethanol...
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Autistic Employees’ Technology-Based Workplace Accommodation Preferences Survey—Preliminary Findings
PublicationBackground: There has been an increase in the number of research studies focused on the design of accommodations aimed at improving the well-being and work performance of autistic employees. These accommodations took various forms; some of them were based on modification of management practices, for example, support in the area of effective communication, or involved modifications to the physical working environment aimed at limiting...
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Prediction of ship resistance with the use of Full-scale CFD simulations
PublicationIn recent years, the IMO has introduced new regulations to reduce the negative impact of ships on the natural environment. A particularly important step forcing technological innovations is the increasing requirement of ship energy efficiency. It is expressed by the Energy Efficiency Design Index (EEDI). Another important step towards green shipping is rising the required quality of fuel used for propulsion, so called Tier limits....
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TiO2 /SrTiO3 and SrTiO3 microspheres decorated with Rh, Ru or Pt nanoparticles: Highly UV–vis responsible photoactivity and mechanism
PublicationA series of TiO2/SrTiO3 and SrTiO3 microspheres decorated by Rh, Ru or Pt NPs were prepared by facile hydrothermal method. The as-prepared samples were characterized by X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS), transmission electron microscopy (TEM) with energy-dispersive Xray (EDX) spectroscopy, scanning electron microscopy (SEM), photoluminescence spectrometry (PL), Fourier transform infrared (FT-IR) and...
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Static Shunt PE Voltage-Quality Controllers
PublicationThis chapter focuses on power electronics (PE)-based solutions used in distribution networks for reduction of supply-voltage-quality deterioration, from long interruptions to the harmonics. Various PE devices and their combinations are addressed for particular or a range of voltage disturbances. A particular solution is applied taking into account demands for voltage quality and network configuration. In general, there are three...
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An additional ultrasonographic sign of Hashimoto’s lymphocytic thyroiditis in children
PublicationWe present an additional sonographic sign of Hashimoto’s thyroiditis (HLT), increasing the specifi city of this method in pediatric populations. Methods: A total of 98 children (mean age 12.7 years, range 7–17 years) were selected from the registry of the endocrinology outpatient department. All subjects met the diagnostic criteria for HLT. All children underwent a prospective thyroid ultrasound examination with special attention...
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Graph Decomposition for Memoryless Periodic Exploration
PublicationWe consider a general framework in which a memoryless robot periodically explores all the nodes of a connected anonymous graph by following local information available at each vertex. For each vertex v, the endpoints of all edges adjacent to v are assigned unique labels within the range 1 to deg (v) (the degree of v). The generic exploration strategy is implemented using a right-hand-rule transition function: after entering vertex...
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Raman investigation of the patina layers on Hungarian copper ingots from a fifteenth century shipwreck
PublicationWe report results of the patina study of underwater archeological finding ofmedieval copper objects performed by means of the Raman and complementary spectroscopic techniques. The objects were found submerged in the sea as cargo part of the ship which sunk in the Gulf of Gdańsk in 1408. The excavated collection consists of 230 oval ingots of the size and mass up to about 60 cm and 18 kg (total of 2 tons), respectively. In the Raman...
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Bacterial Community Structures in Freshwater Polar Environments of Svalbard
PublicationTwo thirds of Svalbard archipelago islands in the High Arctic are permanently covered with glacial ice and snow. Polar bacterial communities in the southern part of Svalbard were characterized using an amplicon sequencing approach. A total of 52,928 pyrosequencing reads were analyzed in order to reveal bacterial community structures in stream and lake surface water samples from the Fuglebekken and Revvatnet...
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Polyurethane Composite Scaffolds Modified with the Mixture of Gelatin and Hydroxyapatite Characterized by Improved Calcium Deposition
PublicationThe skeleton is a crucial element of the motion system in the human body, whose main function is to support and protect the soft tissues. Furthermore, the elements of the skeleton act as a storage place for minerals and participate in the production of red blood cells. The bone tissue includes the craniomaxillofacial bones, ribs, and spine. There are abundant reports in the literature indicating that the amount of treatments related...
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Fake News: Possibility of Identification in Post-Truth Media Ecology System
PublicationInformation comes as basic good which affects social well-being. A modern society and a modern state – its administration, education, culture, national economy and armed forces – cannot function efficiently without a rationally developed field of information. The quality of the functioning of that system depends on a specific feature of information, that is namely: its reliability which makes it possible for us to evaluate accuracy,...
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ATTITUDE OF YOUTH TO SELECT SPECIALTY AND QUALITY OF EDUCATION
PublicationThe problems of young people guidance on the choice of profession according to the labour market requirements and the education quality are considered. The problem of youth education and employment is very topical, and in relation to vocational education the main theoretical and practical approaches to its modernization should be changed. The paper is determined the key aspects for choosing the University to receive education and...
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Number of registered BEV and PHEV vehicles in 2011-2016 (in thousands)
Open Research DataThere are three main types of vehicles that are generally regarded as an electric car. These include:
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A cumulative probability function of instantaneous flicker sensation values measured in the industrial power system supplying the rolling mill motors
Open Research DataThe dataset presents a cumulative probability function CPF of the instantaneous flicker sensation level measured on the bus bars of the main switchgear of the industrial power network for the supply of rolling mills. The data were obtained during an experiment whose purpose was to determine a level of short-term and long-term flicker caused by voltage...
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CONCRETE MIX DESIGN USING SIMPLE EQUATIONS
PublicationThe behaviour of concrete, whether fresh or har dened, depends basically on the beha viour of its components and the r elationship between them, ther efore, obtaining a concr ete with cer tain pr operties depends fundamentally on the concr ete mix design. Concr ete mix design gener ally includes two main steps: 1-Selection of the main components suitable for the concr...
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Linezolid-resistant Enterococcus faecium strains isolated from one hospital in Poland –commensals or hospital-adapted pathogens?
PublicationOne of the most pressing problems of enterococci infections is occurring resistance to linezolid, which is an antibiotic used in the treatment of infections caused by vancomycin-resistant strains (VRE). The main objective of our research was to investigate the relationship of 19 linezolid-resistant E. faecium isolates from 18 patients hospitalized at Clinical Hospital in Gdansk (Poland). One of the LZDREF was isolated in 2003...
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Plant-based meat substitute analysis using microextraction with deep eutectic solvent followed by LC-MS/MS to determine acrylamide, 5-hydroxymethylfurfural and furaneol
PublicationFor the analysis of plant-based meat substitutes and the determination of Maillard reaction products such as acrylamide, 5-hydroxymethylfurfural and furaneol, a novel and effective procedure based on hydrophobic natural deep eutectic solvent and liquid chromatography coupled with tandem mass spectrometry was developed for the first time. The 49 compositions of the deep eutectic solvents were designed and screened to select the...
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Bovine Serum Albumin – Hydroxyapatite Nanoflowers as Potential Local Drug Delivery System of Ciprofloxacin
PublicationIntroduction: Hybrid nanoflowers are structures consisting of organic (enzymes, proteins, nucleic acids) and inorganic components (mostly metal phosphates) with a flower-like hierarchical structure. Novel hybrid nanoflowers based on bovine serum albumin (BSA) and hydroxyapatite (HA) were obtained and characterized. Study on BSA-HA nanoflowers as potential drug delivery system is reported for the first time. Methods: Embedding ciprofloxacin...
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Evaluation and application of data from road weather stations for winter maintenance management
PublicationThe paper presents the analysis of road weather data from meteorological stations located at the Polish national roads of Pomerania District during the impact of winter conditions. Presented issue is particularly important from the point of view the problem of winter maintenance and especially for prediction and assurance of quality of asphalt pavement surface ie. resistance to low temperature cracking or risk of glazed frost....
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Structural evaluation of percolating, self-healing polyurethane–polycaprolactone blends doped with metallic, ferromagnetic, and modified graphene fillers
PublicationComposites with differently shaped micro- and nanofillers show various, unique thermal, and physicochemical properties when mixed with carefully chosen polymer matrix. Selected composition holds strategic value in achieving desired properties that is biodegradability, thermoelectric conductivity, and shape memory for organic coating. The main aim of this work is to briefly examine structural changes after reaching percolation...
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Impact of optimization of ALS point cloud on classification
PublicationAirborne laser scanning (ALS) is one of the LIDAR technologies (Light Detection and Ranging). It provides information about the terrain in form of a point cloud. During measurement is acquired: spatial data (object’s coordinates X, Y, Z) and collateral data such as intensity of reflected signal. The obtained point cloud is typically applied for generating a digital terrain model (DTM) and a digital surface model (DSM). For DTM...
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Field investigation of low-temperature cracking and stiffness moduli on selected roads with conventional and high modulus asphalt concrete
PublicationHigh Modulus Asphalt Concrete (HMAC) was introduced in Poland as a one of the solutions to the problem of rutting, type of deterioration common in the 1990s. After first encouraging trials in 2002 HMAC was widely used for heavily loaded national roads and motorways. However some concerns were raised about low-temperature cracking of HMAC. This was the main reason of the studies presented in this article were started. The article...
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TiO 2 Co x O y composite nanotube arrays via one step electrochemical anodization for visible light–induced photocatalytic reaction
PublicationTiO2CoxOy (x = 1, y = 1 or x = 3, y = 4) composite photocatalysts have been synthesized via one step anodic anodization of TiCo alloys. The effects of the cobalt content in the alloy (5, 10 and 15 wt%), water content (2, 5 and 10%) in the electrolyte solution, and applied voltage (30, 40 and 50 V) during the anodization process on the morphology and surface properties. Additionally, the dependence of cobalt content in the nanotubes...
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Theoretical examination of the fracture behavior of BC3 polycrystalline nanosheets: Effect of crack size and temperature
Publication2D carbon graphene nanostructures are elements of advanced materials and systems. This theoretical survey provides explanation to the mechanical and fracture behavior of mono- and polycrystalline BC3 nanosheets (denoted as MC- and PCBC3NS, respectively) as a function of temperature and the type of crack defects. The mechanical performance of PCBC3NS at elevated temperatures was monitored varying the number of grain boundaries (the...
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Industry-level analysis of COVID-19’s impact in emerging markets – evidence from Pakistan
PublicationPurpose – The main purpose of this study is to evaluate COVID-19’s impact on the emerging stock markets. Design/methodology/approach – To evaluate the influence of COVID-19, this study uses a novel method of event study methodology to measure the impact of COVID-19 on emerging stock markets. The research’s sample includes a total of 79 firms from 26 industries that are included in the KSE-100 Index from the Pakistan Stock Exchange....
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A framework for Air Quality Management Zones - Useful GIS-based tool for urban planning: Case studies in Antwerp and Gdańsk
PublicationThere is a growing recognition of the importance of proper urban design in the improvement of air flow and pollution dispersion and in reducing human exposure to air pollution. However, a limited number of studies have been published so far focusing on the development of standard procedures which could be applied by urban planners to effectively evaluate urban conditions with respect to air quality. To fill this gap, a new approach...
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Structural evaluation of percolating, self-healing polyurethane–polycaprolactone blends doped with metallic, ferromagnetic, and modified graphene fillers
PublicationComposites with differently shaped micro- and nanofillers show various, unique thermal, and physicochemical properties when mixed with carefully chosen polymer matrix. Selected composition holds strategic value in achieving desired properties that is biodegradability, thermoelectric conductivity, and shape memory for organic coating. The main aim of this work is to briefly examine structural changes after reaching percolation threshold...
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New pathways for functionalization of phosphorus ligands
PublicationThe presented dissertation consistsof two main partsand focuses on the synthesis and characterization of new low-valent phosphorus compounds. Thesestudies have already been fully described in three JCR-journals. The first partdescribes the utilization ofselectedphosphanylphosphinidene transition metal complexes as a source of diversified phosphorus ligands. For thispurposethree complexes...
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Innovative Research Into Road Restraint Systems
PublicationKey to understanding the needs and building road infrastructure management tools to prevent and mitigate run-off-road accidents is to identify hazards and their sources which are a result of wrong design, construction, installation and maintenance of road restraint systems [1]. Building such tools requires advanced studies with field tests, simulations and models to demonstrate the effects of selected parameters on road user safety...